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4,183 results on '"Hayman, P."'

1. A Simple Point-Source Boundary Condition for the Schwarzschild Solution

Author

Hayman, Peter

Subjects
General Relativity and Quantum Cosmology
Abstract

We present a simple derivation of a point-source boundary condition for the Schwarzschild solution that relates the Schwarzschild radius to the mass of its source without appealing to the Newtonian limit.

Published
2024

2. Spin migration in density functional theory: energy, potential and density perspectives

Author

Hayman, Alon, Kraisler, Eli, and Stein, Tamar

Subjects
Physics - Chemical Physics, Condensed Matter - Materials Science, Physics - Atomic Physics, Quantum Physics
Abstract

Spin is a fundamental property of any many-electron system. The ability of density functional theory to accurately predict the physical properties of a system, while varying its spin, is crucial for describing magnetic materials and high-spin molecules, spin flip, magnetization and demagnetization processes. Within density functional theory, when using various exchange-correlation approximations, the exact dependence of the energy on the spin often deviates from the exact constant or piecewise-linear behavior, which is directly related to the problem of strong (static) correlation and challenges the description of molecular dissociation. In this paper, we study the behavior of the energy, the frontier Kohn-Sham (KS) orbitals, the KS potentials and the electron density, with respect to fractional spin, in different atomic systems. We analyze five standard exchange-correlation functionals and find three main scenarios of deviation from the expected exact results. We clearly recognize a jump in the frontier orbital energies upon spin variation in the exact exchange and in hybrid functionals, and the related plateau in the corresponding KS potential. Our results are instrumental for the assessment of the quality of existing approximations from a new perspective and for the development of advanced functionals with sensitivity to magnetic properties.

Published
2024

3. The CRAFT Coherent (CRACO) upgrade I: System Description and Results of the 110-ms Radio Transient Pilot Survey

Author

Wang, Z., Bannister, K. W., Gupta, V., Deng, X., Pilawa, M., Tuthill, J., Bunton, J. D., Flynn, C., Glowacki, M., Jaini, A., Lee, Y. W. J., Lenc, E., Lucero, J., Paek, A., Radhakrishnan, R., Thyagarajan, N., Uttarkar, P., Wang, Y., Bhat, N. D. R., James, C. W., Moss, V. A., Murphy, Tara, Reynolds, J. E., Shannon, R. M., Spitler, L. G., Tzioumis, A., Caleb, M., Deller, A. T., Gordon, A. C., Marnoch, L., Ryder, S. D., Simha, S., Anderson, C. S., Ball, L., Brodrick, D., Cooray, F. R., Gupta, N., Hayman, D. B., Ng, A., Pearce, S. E., Phillips, C., Voronkov, M. A., and Westmeier, T.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We present the first results from a new backend on the Australian Square Kilometre Array Pathfinder, the Commensal Realtime ASKAP Fast Transient COherent (CRACO) upgrade. CRACO records millisecond time resolution visibility data, and searches for dispersed fast transient signals including fast radio bursts (FRB), pulsars, and ultra-long period objects (ULPO). With the visibility data, CRACO can localise the transient events to arcsecond-level precision after the detection. Here, we describe the CRACO system and report the result from a sky survey carried out by CRACO at 110ms resolution during its commissioning phase. During the survey, CRACO detected two FRBs (including one discovered solely with CRACO, FRB 20231027A), reported more precise localisations for four pulsars, discovered two new RRATs, and detected one known ULPO, GPM J1839-10, through its sub-pulse structure. We present a sensitivity calibration of CRACO, finding that it achieves the expected sensitivity of 11.6 Jy ms to bursts of 110 ms duration or less. CRACO is currently running at a 13.8 ms time resolution and aims at a 1.7 ms time resolution before the end of 2024. The planned CRACO has an expected sensitivity of 1.5 Jy ms to bursts of 1.7 ms duration or less, and can detect 10x more FRBs than the current CRAFT incoherent sum system (i.e., 0.5-2 localised FRBs per day), enabling us to better constrain he models for FRBs and use them as cosmological probes., Comment: 26 pages, 19 figures, 9 tables, Accepted for publication in PASA

Published
2024

4. The First Large Absorption Survey in HI (FLASH): II. Pilot Survey data release and first results

Author

Yoon, Hyein, Sadler, Elaine M., Mahony, Elizabeth K., Aditya, J. N. H. S., Allison, James R., Glowacki, Marcin, Kerrison, Emily F., Moss, Vanessa A., Su, Renzhi, Weng, Simon, Whiting, Matthew, Wong, O. Ivy, Callingham, Joseph R., Curran, Stephen J., Darling, Jeremy, Edge, Alastair C., Ellison, Sara L., Emig, Kimberly L., Garratt-Smithson, Lilian, German, Gordon, Grasha, Kathryn, Koribalski, Baerbel S., Morganti, Raffaella, Oosterloo, Tom, Péroux, Céline, Pettini, Max, Pimbblet, Kevin A., Zheng, Zheng, Zwaan, Martin, Ball, Lewis, Bock, Douglas C. -J., Brodrick, David, Bunton, John D., Cooray, F. R., Edwards, Philip G., Hayman, Douglas B., Hotan, Aidan W., Lee-Waddell, K., McClure-Griffiths, N. M., Ng, A., Phillips, Chris J., Raja, Wasim, Voronkov, Maxim A., and Westmeier, Tobias

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

The First Large Absorption Survey in HI (FLASH) is a large-area radio survey for neutral hydrogen in the redshift range 0.41$, and appear to be a mixture of intervening and associated systems. The overall detection rate for HI absorption lines in the Pilot Surveys (0.3 to 0.5 lines per ASKAP field) is a factor of two below the expected value. There are several possible reasons for this, but one likely factor is the presence of a range of spectral-line artefacts in the Pilot Survey data that have now been mitigated and are not expected to recur in the full FLASH survey. A future paper will discuss the host galaxies of the HI absorption systems identified here., Comment: 46 pages, 25 figures, 10 tables. Submitted to PASA

Published
2024

5. Hybrid Quantum-Classical Photonic Neural Networks

Author

Austin, Tristan, Bilodeau, Simon, Hayman, Andrew, Rotenberg, Nir, and Shastri, Bhavin

Subjects
Quantum Physics, Physics - Optics
Abstract

Neuromorphic (brain-inspired) photonics leverages photonic chips to accelerate artificial intelligence, offering high-speed and energy efficient solutions in RF communication, tensor processing, and data classification. However, the limited physical size of integrated photonic hardware constrains network complexity and computational capacity. In light of recent advances in photonic quantum technology, it is natural to utilize quantum exponential speedup to scale photonic neural network capabilities. Here we show a combination of classical network layers with trainable continuous variable quantum circuits yields hybrid networks with improved trainability and accuracy. On a classification task, hybrid networks achieve the same performance when benchmarked against fully classical networks that are twice the size. When the bit precision of the optimized networks is reduced through added noise, the hybrid networks still achieve greater accuracy when evaluated at state of the art bit precision. These hybrid quantum classical networks demonstrate a unique route to improve computational capacity of integrated photonic neural networks without increasing the physical network size.

Published
2024

6. Optimized sampling of SDSS-IV MaStar spectra for stellar classification using supervised models

Author

El-Kholy, R. I. and Hayman, Z. M.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Supervised machine learning models are increasingly being used for solving the problem of stellar classification of spectroscopic data. However, training such models requires a large number of labelled instances, the collection of which is usually costly in both time and expertise. Active learning algorithms minimize training dataset sizes by keeping only the most informative instances. This paper explores the application of active learning to sampling stellar spectra using data from a highly class-imbalanced dataset. We utilize the MaStar library from the SDSS DR17 along with its associated stellar parameter catalogue. A preprocessing pipeline that includes feature selection, scaling, and dimensionality reduction is applied to the data. Using different active learning algorithms, we iteratively query instances, where the model or committee of models exhibits the highest uncertainty or disagreement, respectively. We assess the effectiveness of the sampling techniques by comparing several performance metrics of supervised-learning models trained on the queried samples with randomly-sampled counterparts. Evaluation metrics include specificity, sensitivity, and the area under the curve; in addition to the Matthew's correlation coefficient, which accounts for class imbalance. We apply this procedure to effective temperature, surface gravity, and iron metallicity, separately. Our results demonstrate the effectiveness of active learning algorithms in selecting samples that produce performance metrics superior to random sampling and even stratified samples, with fewer training instances. Active learning is recommended for prioritizing instance labelling of astronomical-survey data by experts or crowdsourcing to mitigate the high time cost. Its effectiveness can be further exploited in selection of targets for follow-up observations in automated astronomical surveys., Comment: 15 pages, 14 figures, 3 tables, comments are welcome

Published
2024

7. Estimating the household secondary attack rate with the Incomplete Chain Binomial model

Author

Lindstrøm, Jonas Christoffer, Bekkevold, Terese, Julin, Cathinka Halle, Robertson, Anna Hayman, and Næss, Lisbeth Meyer

Subjects
Statistics - Methodology, Physics - Physics and Society, Quantitative Biology - Populations and Evolution
Abstract

The Secondary Attack Rate (SAR) is a measure of how infectious a communicable disease is, and is often estimated based on studies of disease transmission in households. The Chain Binomial model is a simple model for disease outbreaks, and the final size distribution derived from it can be used to estimate the SAR using simple summary statistics. The final size distribution of the Chain Binomial model assume that the outbreaks have concluded, which in some instances may require long follow-up time. We develop a way to compute the probability distribution of the number of infected before the outbreak has concluded, which we call the Incomplete Chain Binomial distribution. We study a few theoretical properties of the model. We develop Maximum Likelihood estimation routines for inference on the SAR and explore the model by analyzing two real world data sets., Comment: 16 pages

Published
2024

13. Global Estimation of Range Resolved Thermodynamic Profiles from MicroPulse Differential Absorption Lidar

Author

Hayman, Matthew, Stillwell, Robert A., Karboski, Adam, Marais, Willem J., and Spuler, Scott M.

Subjects
Electrical Engineering and Systems Science - Signal Processing, Physics - Optics
Abstract

We demonstrate thermodynamic profile estimation with data obtained using the MicroPulse DIAL such that the retrieval is entirely self contained. The only external input is surface meteorological variables obtained from a weather station installed on the instrument. The estimator provides products of temperature, absolute humidity and backscatter ratio such that cross dependencies between the lidar data products and raw observations are accounted for and the final products are self consistent. The method described here is applied to a combined oxygen DIAL, potassium HSRL, water vapor DIAL system operating at two pairs of wavelengths (nominally centered at 770 and 828 nm). We perform regularized maximum likelihood estimation through the Poisson Total Variation technique to suppress noise and improve the range of the observations. A comparison to 119 radiosondes indicates that this new processing method produces improved temperature retrievals, reducing total errors to less than 2 K below 3 km altitude and extending the maximum altitude of temperature retrievals to 5 km with less than 3 K error. The results of this work definitively demonstrates the potential for measuring temperature through the oxygen DIAL technique and furthermore that this can be accomplished with low-power semiconductor-based lidar sensors.

Published
2024

15. Treatment patterns for AL amyloidosis after frontline daratumumab, bortezomib, cyclophosphamide, and dexamethasone treatment failures

Author

Zanwar, Saurabh, Gertz, Morie A., Muchtar, Eli, Buadi, Francis K., Kourelis, Taxiarchis, Gonsalves, Wilson, Go, Ronald S., Hayman, Suzanne, Kapoor, Prashant, Binder, Moritz, Cook, Joselle, Dingli, David, Leung, Nelson, Lin, Yi, Warsame, Rahma, Fonder, Amie, Hobbs, Miriam, Hwa, Yi Lisa, Kyle, Robert A., Rajkumar, S. Vincent, Kumar, Shaji, and Dispenzieri, Angela

Published
2024
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16. Post-inflationary structure formation boosted by parametric self-resonance

Author

Eggemeier, Benedikt, Hayman, Peter, Niemeyer, Jens C., and Easther, Richard

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Phenomenology
Abstract

The post-inflationary Universe can pass through a long epoch of effective matter-dominated expansion. This era may allow for both the parametric amplification of initial fluctuations and the gravitational collapse of inflaton perturbations. We perform first-of-their-kind high-resolution simulations that span the resonant phase and the subsequent gravitational collapse of the inflaton field by seguing from a full Klein-Gordon treatment of resonance to a computationally efficient Schr\"odinger-Poisson description that accurately captures the gravitational dynamics when most quanta are nonrelativistic. We consider a representative example in which resonance generates $\mathcal{O}(10^{-1})$ overdensities and gravitational collapse follows promptly as resonance ends. We observe the formation of solitonic cores inside inflaton halos and complex gravitational dynamics on scales of $10^{-27}\,\mathrm{m}$, greatly extending the possible scope of nonlinear post-inflationary gravitational dynamics., Comment: 11 pages, 8 figures, matches version accepted in Phys Rev D

Published
2023
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17. Goodhart's Law in Reinforcement Learning

Author

Karwowski, Jacek, Hayman, Oliver, Bai, Xingjian, Kiendlhofer, Klaus, Griffin, Charlie, and Skalse, Joar

Subjects
Computer Science - Machine Learning
Abstract

Implementing a reward function that perfectly captures a complex task in the real world is impractical. As a result, it is often appropriate to think of the reward function as a proxy for the true objective rather than as its definition. We study this phenomenon through the lens of Goodhart's law, which predicts that increasing optimisation of an imperfect proxy beyond some critical point decreases performance on the true objective. First, we propose a way to quantify the magnitude of this effect and show empirically that optimising an imperfect proxy reward often leads to the behaviour predicted by Goodhart's law for a wide range of environments and reward functions. We then provide a geometric explanation for why Goodhart's law occurs in Markov decision processes. We use these theoretical insights to propose an optimal early stopping method that provably avoids the aforementioned pitfall and derive theoretical regret bounds for this method. Moreover, we derive a training method that maximises worst-case reward, for the setting where there is uncertainty about the true reward function. Finally, we evaluate our early stopping method experimentally. Our results support a foundation for a theoretically-principled study of reinforcement learning under reward misspecification.

Published
2023

18. Space Observation by the Australia Telescope Compact Array: Performance Characterization using GPS Satellite Observation

Author

Nosrati, Hamed, Smith, Stephanie, and Hayman, Douglas B.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Electrical Engineering and Systems Science - Signal Processing
Abstract

In order to operationalize the Australia Telescope Compact Array (ATCA) for space situational awareness (SSA) applications, we develop a system model for range and direction of arrival (DOA) estimation based on the interferometric data. We employ the observational data collected from global positioning system (GPS) satellites to evaluate the developed model and demonstrate that, compared to a priori location propagated from the most recent two-line element (TLE), both range and direction information are improved significantly.

Published
2023

19. Changes in motor unit behaviour across repeated bouts of eccentric exercise

Author

Oliver Hayman, Paul Ansdell, Luca Angius, Kevin Thomas, Lauren Horsbrough, Glyn Howatson, Dawson J. Kidgell, Jakob Škarabot, and Stuart Goodall

Subjects
fatigue, high‐density electromyography, motoneuron, muscle damage, recovery, Physiology, QP1-981
Abstract

Abstract Unaccustomed eccentric exercise (EE) is protective against muscle damage following a subsequent bout of similar exercise. One hypothesis suggests the existence of an alteration in motor unit (MU) behaviour during the second bout, which might contribute to the adaptive response. Accordingly, the present study investigated MU changes during repeated bouts of EE. During two bouts of exercise where maximal lengthening dorsiflexion (10 repetitions × 10 sets) was performed 3 weeks apart, maximal voluntary isometric torque (MVIC) and MU behaviour (quantified using high‐density electromyography; HDsEMG) were measured at baseline, during (after set 5), and post‐EE. The HDsEMG signals were decomposed into individual MU discharge timings, and a subset were tracked across each time point. MVIC was reduced similarly in both bouts post‐EE (Δ27 vs. 23%, P = 0.144), with a comparable amount of total work performed (∼1,300 J; P = 0.905). In total, 1,754 MUs were identified and the decline in MVIC was accompanied by a stepwise increase in discharge rate (∼13%; P

Published
2024
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20. Supporting alcohol brief interventions and pharmacotherapy provision in Australian First Nations primary care: exploratory analysis of a cluster randomised trial

Author

Monika Dzidowska, KS Kylie Lee, James H. Conigrave, Scott Wilson, Noel Hayman, Rowena Ivers, Julia Vnuk, Paul Haber, and Katherine M. Conigrave

Subjects
Alcohol, Aboriginal community controlled health organisation, Pharmacotherapy, Brief intervention, Counselling, Relapse prevention, Medicine (General), R5-920
Abstract

Abstract Introduction Primary care provides an important opportunity to detect unhealthy alcohol use and offer assistance but many barriers to this exist. In an Australian context, Aboriginal Community Controlled Health Services (ACCHS) are community-led and run health services, which provide holistic primary care to Aboriginal and Torres Strait Islander peoples. A recent cluster randomised trial conducted with ACCHS provided a service support model which showed a small but significant difference in provision of ‘any treatment’ for unhealthy alcohol use. However, it was not clear which treatment modalities were increased. Aims To test the effect of an ACCHS support model for alcohol on: (i) delivery of verbal alcohol intervention (alcohol advice or counselling); (ii) prescription of relapse prevention pharmacotherapies. Methods Intervention: 24-month, multi-faceted service support model. Design: cluster randomised trial; equal allocation to early-support (‘treatment’) and waitlist control arms. Participants: 22 ACCHS. Analysis: Multilevel logistic regression to compare odds of a client receiving treatment in any two-month period as routinely recorded on practice software. Results Support was associated with a significant increase in the odds of verbal alcohol intervention being recorded (OR = 7.60, [95% CI = 5.54, 10.42], p

Published
2024
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21. Navigating the First Year at an English University: Exploring the Experiences of Mature Students through the Lens of Transition Theory

Author

Rick Hayman, Karl Wharton, Laura Bell, and Livia Bird

Abstract

Previous research has revealed how mature students are more likely to drop out of university education, achieve poorer degree outcomes and have greater family, financial, caring and work commitments to contend with than their younger peers. In response to calls for further empirical work on mature students' university experiences and informed theoretically by Transition Theory, the primary study aim was to explore the day-to-day encounters of 12 newly enrolled undergraduate mature students as they completed their first year of study at an English university in a post pandemic era. Supportive with previous research, participants were found to be academically but not socially and emotionally engaged. Having placed significant time and effort into their studies and achieved relative academic success, their expectations of university life were only partly met with most encountering a socially, emotionally and financially challenging first year. Practical implications for developing increasingly flexible and relational rich modes of educational provision that best address and support the needs, abilities, motivations, and expectations of mature students as they complete their university studies in a digital world are provided, as are future research avenues and limitations.

Published
2024
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23. Characterization of the SARS-CoV-2 antibody landscape in Norway in the late summer of 2022: high seroprevalence in all age groups with patterns of primary Omicron infection in children and hybrid immunity in adults

Author

Tunheim, Gro, Fossum, Even, Robertson, Anna Hayman, Rø, Gunnar Øyvind Isaksson, Chopra, Adity, Vaage, John T., Vikse, Elisabeth Lea, Kran, Anne-Marte Bakken, Magnus, Per, Trogstad, Lill, Mjaaland, Siri, Hungnes, Olav, and Lund-Johansen, Fridtjof

Published
2024
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25. Clinical features associated with poor response and early relapse following BCMA-directed therapies in multiple myeloma

Author

Rees, Matthew J., Mammadzadeh, Aytaj, Bolarinwa, Abiola, Elhaj, Mohammed E., Bohra, Arwa, Bansal, Radhika, Ailawadhi, Sikander, Parrondo, Ricardo, Chhabra, Saurabh, Khot, Amit, Hayman, Suzanne, Dispenzieri, Angela, Buadi, Francis, Dingli, David, Warsame, Rahma, Kapoor, Prashant, Gertz, Morie A., Muchtar, Eli, Kourelis, Taxiarchis, Gonsalves, Wilson, Rajkumar, S. Vincent, Lin, Yi, and Kumar, Shaji

Published
2024
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26. Health and wellbeing of staff working at higher education institutions globally during the post-COVID-19 pandemic period: evidence from a cross-sectional study

Author

Rahman, Muhammad Aziz, Das, Pritimoy, Lam, Louisa, Alif, Sheikh M., Sultana, Farhana, Salehin, Masudus, Banik, Biswajit, Joseph, Bindu, Parul, Parul, Lewis, Andrew, Statham, Dixie, Porter, Joanne, Foster, Kim, Islam, Sheikh Mohammed Shariful, Cross, Wendy, Jacob, Alycia, Hua, Susan, Wang, Qun, Chair, Sek Ying, Chien, Wai Tong, Widati, Sri, Nurmala, Ira, Puspaningsih, Ni Nyoman Tri, Hammoud, Majeda, Omar, Khatijah, Halim, Muhammad Abi Sofian Abdul, Gamal-Eltrabily, Mohammed, Ortiz, Georgina, Al Maskari, Turkiya Saleh, Al Alawi, Salwa Saleh Mohammed, Al-Rahbi, Badriya Saleh, Arulappan, Judie, Ahmad, Akhlaq, Al Laham, Nahed, Mahmud, Ilias, Alasqah, Ibrahim, Noorbhai, Habib, Chang, Shao-Liang, Chen, Yi-Lung, Comlekci, Mehmet Fatih, Basol, Oguz, Saddik, Basema, Hayman, Rick, and Polman, Remco

Published
2024
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28. Correction: The One Health High-Level Expert Panel (OHHLEP)

Author

Mettenleiter, Thomas C., Markotter, Wanda, Charron, Dominique F., Adisasmito, Wiku B., Almuhairi, Salama, Behravesh, Casey Barton, Bilivogui, Pépé, Bukachi, Salome A., Casas, Natalia, Becerra, Natalia Cediel, Chaudhary, Abhishek, Ciacci Zanella, Janice R., Cunningham, Andrew A., Dar, Osman, Debnath, Nitish, Dungu, Baptiste, Farag, Elmoubasher, Gao, George F., Hayman, David T. S., Khaitsa, Margaret, Koopmans, Marion P. G., Machalaba, Catherine, Mackenzie, John S., Morand, Serge, Smolenskiy, Vyacheslav, and Zhou, Lei

Published
2024
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29. Outcomes of patients with multiple myeloma refractory to standard dose vs low dose lenalidomide

Author

Goel, Utkarsh, Charalampous, Charalampos, Kapoor, Prashant, Binder, Moritz, Buadi, Francis K., Dingli, David, Dispenzieri, Angela, Fonder, Amie, Gertz, Morie A., Gonsalves, Wilson I., Hayman, Suzanne R., Hobbs, Miriam A., Hwa, Yi L., Kourelis, Taxiarchis, Lacy, Martha Q., Leung, Nelson, Lin, Yi, Warsame, Rahma M., Kyle, Robert A., Rajkumar, S. Vincent, and Kumar, Shaji K.

Published
2024
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33. Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions

Author

Purdue, Mark P., Dutta, Diptavo, Machiela, Mitchell J., Gorman, Bryan R., Winter, Timothy, Okuhara, Dayne, Cleland, Sara, Ferreiro-Iglesias, Aida, Scheet, Paul, Liu, Aoxing, Wu, Chao, Antwi, Samuel O., Larkin, James, Zequi, Stênio C., Sun, Maxine, Hikino, Keiko, Hajiran, Ali, Lawson, Keith A., Cárcano, Flavio, Blanchet, Odile, Shuch, Brian, Nepple, Kenneth G., Margue, Gaëlle, Sundi, Debasish, Diver, W. Ryan, Folgueira, Maria A. A. K., van Bokhoven, Adrie, Neffa, Florencia, Brown, Kevin M., Hofmann, Jonathan N., Rhee, Jongeun, Yeager, Meredith, Cole, Nathan R., Hicks, Belynda D., Manning, Michelle R., Hutchinson, Amy A., Rothman, Nathaniel, Huang, Wen-Yi, Linehan, W. Marston, Lori, Adriana, Ferragu, Matthieu, Zidane-Marinnes, Merzouka, Serrano, Sérgio V., Magnabosco, Wesley J., Vilas, Ana, Decia, Ricardo, Carusso, Florencia, Graham, Laura S., Anderson, Kyra, Bilen, Mehmet A., Arciero, Cletus, Pellegrin, Isabelle, Ricard, Solène, Scelo, Ghislaine, Banks, Rosamonde E., Vasudev, Naveen S., Soomro, Naeem, Stewart, Grant D., Adeyoju, Adebanji, Bromage, Stephen, Hrouda, David, Gibbons, Norma, Patel, Poulam, Sullivan, Mark, Protheroe, Andrew, Nugent, Francesca I., Fournier, Michelle J., Zhang, Xiaoyu, Martin, Lisa J., Komisarenko, Maria, Eisen, Timothy, Cunningham, Sonia A., Connolly, Denise C., Uzzo, Robert G., Zaridze, David, Mukeria, Anush, Holcatova, Ivana, Hornakova, Anna, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Jinga, Viorel, Rascu, Stefan, Mijuskovic, Mirjana, Savic, Slavisa, Milosavljevic, Sasa, Gaborieau, Valérie, Abedi-Ardekani, Behnoush, McKay, James, Johansson, Mattias, Phouthavongsy, Larry, Hayman, Lindsay, Li, Jason, Lungu, Ilinca, Bezerra, Stephania M., Souza, Aline G., Sares, Claudia T. G., Reis, Rodolfo B., Gallucci, Fabio P., Cordeiro, Mauricio D., Pomerantz, Mark, Lee, Gwo-Shu M., Freedman, Matthew L., Jeong, Anhyo, Greenberg, Samantha E., Sanchez, Alejandro, Thompson, R. Houston, Sharma, Vidit, Thiel, David D., Ball, Colleen T., Abreu, Diego, Lam, Elaine T., Nahas, William C., Master, Viraj A., Patel, Alpa V., Bernhard, Jean-Christophe, Freedman, Neal D., Bigot, Pierre, Reis, Rui M., Colli, Leandro M., Finelli, Antonio, Manley, Brandon J., Terao, Chikashi, Choueiri, Toni K., Carraro, Dirce M., Houlston, Richard, Eckel-Passow, Jeanette E., Abbosh, Philip H., Ganna, Andrea, Brennan, Paul, Gu, Jian, and Chanock, Stephen J.

Published
2024
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36. C5 Palsy after Cervical Disc Arthroplasty: Two Case Reports and Literature Review

Author

César Carballo Cuello, Gabriel Flores Milan, Nicolas Baerga, Mark Greenberg, Puya Alikhani, and Erik Hayman

Subjects
C5 palsy, cervical arthroplasty, anterior cervical discectomy, Surgery, RD1-811
Abstract

Cervical disc arthroplasty (CDA), also known as cervical artificial disc replacement, has become an alternative for the treatment of cervical spondylosis with radicular or myelopathic symptoms. However, there is limited literature regarding its complications and outcomes. We present two cases that developed C5 nerve palsy (C5P) following two-level CDA. Both patients presented with C5P in a delayed fashion with 2/5 and 1/5 deltoid weakness on MMT, respectively. Postoperative imaging did not demonstrate any spinal cord compression and symptoms resolved (5/5 on MMT) with conservative management in both cases. To our knowledge, these represent the first cases of delayed C5P after cervical arthroplasty reported in the literature. We performed a literature review to further enhance our knowledge regarding CDA. By understanding its pathophysiology and response to treatment, these cases can serve as a guide for spine surgeons and improve their future outcomes.

Published
2024
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37. Measurement of Dielectric Properties of Thin Materials for Radomes Using Waveguide Cavities

Author

Tayla Dahms, Douglas B. Hayman, Bahare Mohamadzade, and Stephanie L. Smith

Subjects
radomes, dielectrics, thin materials, permittivity, loss tangent, waveguides, Computer engineering. Computer hardware, TK7885-7895, Electronic computers. Computer science, QA75.5-76.95
Abstract

We present waveguide cavity measurements used to evaluate several thin materials for use in radomes. In addition to the data on the materials, we show how these measurements can be performed with common laboratory equipment and simple calculations. We sought an approach that allowed candidate materials to be readily evaluated to deal with formerly selected materials becoming unavailable or cost-prohibitive. We used lengths of standard waveguide (WR650 and WR137 here) with readily manufactured irises and a vector network analyzer (Keysight N5225B here). To select the iris size and determine the limits of the simplifications in the equations used, we employed a full-wave 3D electromagnetic simulator (CST Microwave Studio). The equations required to calculate the dielectric properties of samples and their contribution to the equivalent system noise temperature from unloaded and loaded resonant frequencies and Q factors are shown. While these formulations can be found elsewhere, we did not find these assembled as conveniently in other studies in the literature. We also show that orienting the sample down the length of the cavity allows for higher-order modes to be fully utilized. We did not find this straightforward adaptation of the common cross-guide orientation in other works. Overall, the results allowed us to recommend three fabrics for use at the frequencies tested (1.7 and 5.6 GHz). The complete process is outlined to assist others in performing these measurements themselves.

Published
2024
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38. Characterization of the SARS-CoV-2 antibody landscape in Norway in the late summer of 2022: high seroprevalence in all age groups with patterns of primary Omicron infection in children and hybrid immunity in adults

Author

Gro Tunheim, Even Fossum, Anna Hayman Robertson, Gunnar Øyvind Isaksson Rø, Adity Chopra, John T. Vaage, Elisabeth Lea Vikse, Anne-Marte Bakken Kran, Per Magnus, Lill Trogstad, Siri Mjaaland, Olav Hungnes, and Fridtjof Lund-Johansen

Subjects
Seroprevalence, SARS-CoV-2, Antibodies, Children, Omicron, Wuhan, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background According to Norwegian registries, 91% of individuals ≥ 16 years had received ≥ 1 dose of COVID-19 vaccine by mid-July 2022, whereas less than 2% of children

Published
2024
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39. Clinical features associated with poor response and early relapse following BCMA-directed therapies in multiple myeloma

Author

Matthew J. Rees, Aytaj Mammadzadeh, Abiola Bolarinwa, Mohammed E. Elhaj, Arwa Bohra, Radhika Bansal, Sikander Ailawadhi, Ricardo Parrondo, Saurabh Chhabra, Amit Khot, Suzanne Hayman, Angela Dispenzieri, Francis Buadi, David Dingli, Rahma Warsame, Prashant Kapoor, Morie A. Gertz, Eli Muchtar, Taxiarchis Kourelis, Wilson Gonsalves, S. Vincent Rajkumar, Yi Lin, and Shaji Kumar

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Three classes of BCMA-directed therapy (BDT) exist: antibody drug-conjugates (ADCs), CAR-T, and T-cell engagers (TCEs), each with distinct strengths and weaknesses. To aid clinicians in selecting between BDTs, we reviewed myeloma patients treated at Mayo Clinic with commercial or investigational BDT between 2018-2023. We identified 339 individuals (1-exposure = 297, 2-exposures = 38, 3-exposures = 4) who received 385 BDTs (ADC = 59, TCE = 134, CAR-T = 192), with median follow-up of 21-months. ADC recipients were older, with more lines of therapy (LOT), and penta-refractory disease. Compared to ADCs, CAR-T (aHR = 0.29, 95%CI = 0.20–0.43) and TCEs (aHR = 0.62, 95%CI = 0.43–0.91) had better progression-free survival (PFS) on analysis adjusted for age, the presence of extramedullary (EMD), penta-refractory disease, multi-hit high-risk cytogenetics, prior BDT, and the number of LOT in the preceding 1-year. Likewise, compared to ADCs, CAR-T (aHR = 0.28, 95%CI = 0.18–0.44) and TCEs (aHR = 0.60, 95%CI = 0.39–0.93) had superior overall survival. Prior BDT exposure negatively impacted all classes but was most striking in CAR-T, ORR 86% vs. 50% and median PFS 13-months vs. 3-months. Of relapses, 54% were extramedullary in nature, and a quarter of these cases had no history of EMD. CAR-T demonstrates superior efficacy and where feasible, should be the initial BDT. However, for patients with prior BDT or rapidly progressive disease, an alternative approach may be preferable.

Published
2024
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40. Health and wellbeing of staff working at higher education institutions globally during the post-COVID-19 pandemic period: evidence from a cross-sectional study

Author

Muhammad Aziz Rahman, Pritimoy Das, Louisa Lam, Sheikh M. Alif, Farhana Sultana, Masudus Salehin, Biswajit Banik, Bindu Joseph, Parul Parul, Andrew Lewis, Dixie Statham, Joanne Porter, Kim Foster, Sheikh Mohammed Shariful Islam, Wendy Cross, Alycia Jacob, Susan Hua, Qun Wang, Sek Ying Chair, Wai Tong Chien, Sri Widati, Ira Nurmala, Ni Nyoman Tri Puspaningsih, Majeda Hammoud, Khatijah Omar, Muhammad Abi Sofian Abdul Halim, Mohammed Gamal-Eltrabily, Georgina Ortiz, Turkiya Saleh Al Maskari, Salwa Saleh Mohammed Al Alawi, Badriya Saleh Al-Rahbi, Judie Arulappan, Akhlaq Ahmad, Nahed Al Laham, Ilias Mahmud, Ibrahim Alasqah, Habib Noorbhai, Shao-Liang Chang, Yi-Lung Chen, Mehmet Fatih Comlekci, Oguz Basol, Basema Saddik, Rick Hayman, and Remco Polman

Subjects
Health, Job insecurity, Resilient coping, University staff, Mental health, Public aspects of medicine, RA1-1270
Abstract

Abstract Background The ongoing global crisis of Higher Education (HE) institutions during the post-COVID-19 pandemic period has increased the likelihood of enduring psychological stressors for staff. This study aimed to identify factors associated with job insecurity, burnout, psychological distress and coping amongst staff working at HE institutions globally. Methods An anonymous cross-sectional study was conducted in 2023 with staff at HE institutions across 16 countries. Job insecurity was measured using the Job Insecurity Scale (JIS), burnout using the Perceived Burnout measure question, psychological distress using the Kessler Psychological Distress Scale (K10), and coping using the Brief Resilient Coping Scale. Multivariable logistic regression with a stepwise variable selection method was used to identify associations. Results A total of 2,353 staff participated; the mean age (± SD) was 43(± 10) years and 61% were females. Most staff (85%) did not feel job insecurity, one-third (29%) perceived burnout in their jobs, more than two-thirds (73%) experienced moderate to very high levels of psychological distress, and more than half (58%) exhibited medium to high resilient coping. Perceived job insecurity was associated with staff working part-time [Adjusted Odds Ratio 1.53 (95% Confidence Intervals 1.15–2.02)], having an academic appointment [2.45 (1.78–3.27)], having multiple co-morbidities [1.86 (1.41–2.48)], perceived burnout [1.99 (1.54–2.56)] and moderate to very high level of psychological distress [1.68 (1.18–2.39)]. Perceived burnout was associated with being female [1.35 (1.12–1.63)], having multiple co-morbidities [1.53 (1.20–1.97)], perceived job insecurity [1.99 (1.55–2.57)], and moderate to very high levels of psychological distress [3.23 (2.42–4.30)]. Staff with multiple co-morbidities [1.46 (1.11–1.92)], mental health issues [2.73 (1.79–4.15)], perceived job insecurity [1.61 (1.13–2.30)], and perceived burnout [3.22 (2.41–4.31)] were associated with moderate to very high levels of psychological distress. Staff who perceived their mental health as good to excellent [3.36 (2.69–4.19)] were more likely to have medium to high resilient coping. Conclusions Factors identified in this study should be considered in reviewing and updating current support strategies for staff at HE institutions across all countries to reduce stress and burnout and improve wellbeing.

Published
2024
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41. A review of public health guidelines for postpartum physical activity and sedentary behavior from around the world

Author

Kelly R. Evenson, Wendy J. Brown, Alison K. Brinson, Emily Budzynski-Seymour, and Melanie Hayman

Subjects
Breastfeeding, Caesarean section, Guidelines, Postnatal, Recommendations, Sports, GV557-1198.995, Sports medicine, RC1200-1245
Abstract

Background: The period following pregnancy is a critical time window when future habits with respect to physical activity (PA) and sedentary behavior (SB) are established; therefore, it warrants guidance. The purpose of this scoping review was to summarize public health-oriented country-specific postpartum PA and SB guidelines worldwide. Methods: To identify guidelines published since 2010, we performed a (a) systematic search of 4 databases (CINAHL, Global Health, PubMed, and SPORTDiscus), (b) structured repeatable web-based search separately for 194 countries, and (c) separate web-based search. Only the most recent guideline was included for each country. Results: We identified 22 countries with public health-oriented postpartum guidelines for PA and 11 countries with SB guidelines. The continents with guidelines included Europe (n = 12), Asia (n = 5), Oceania (n = 2), Africa (n = 1), North America (n = 1), and South America (n = 1). The most common benefits recorded for PA included weight control/management (n = 10), reducing the risk of postpartum depression or depressive symptoms (n = 9), and improving mood/well-being (n = 8). Postpartum guidelines specified exercises to engage in, including pelvic floor exercises (n = 17); muscle strengthening, weight training, or resistance exercises (n = 13); aerobics/general aerobic activity (n = 13); walking (n = 11); cycling (n = 9); and swimming (n = 9). Eleven guidelines remarked on the interaction between PA and breastfeeding; several guidelines stated that PA did not impact breast milk quantity (n = 7), breast milk quality (n = 6), or infant growth (n = 3). For SB, suggestions included limiting long-term sitting and interrupting sitting with PA. Conclusion: Country-specific postpartum guidelines for PA and SB can help promote healthy behaviors using a culturally appropriate context while providing specific guidance to public health practitioners.

Published
2024
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42. Ectoparasite and bacterial population genetics and community structure indicate extent of bat movement across an island chain

Author

Clifton D. McKee, Alison J. Peel, David T. S. Hayman, Richard Suu-Ire, Yaa Ntiamoa-Baidu, Andrew A. Cunningham, James L. N. Wood, Colleen T. Webb, and Michael Y. Kosoy

Subjects
Africa, Bartonella, bat flies, Chiroptera, endosymbionts, host–microbe interactions, Nycteribiidae, phylogeography, Biochemistry, QD415-436, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
Abstract

Few studies have examined the genetic population structure of vector-borne microparasites in wildlife, making it unclear how much these systems can reveal about the movement of their associated hosts. This study examined the complex host–vector–microbe interactions in a system of bats, wingless ectoparasitic bat flies (Nycteribiidae), vector-borne microparasitic bacteria (Bartonella) and bacterial endosymbionts of flies (Enterobacterales) across an island chain in the Gulf of Guinea, West Africa. Limited population structure was found in bat flies and Enterobacterales symbionts compared to that of their hosts. Significant isolation by distance was observed in the dissimilarity of Bartonella communities detected in flies from sampled populations of Eidolon helvum bats. These patterns indicate that, while genetic dispersal of bats between islands is limited, some non-reproductive movements may lead to the dispersal of ectoparasites and associated microbes. This study deepens our knowledge of the phylogeography of African fruit bats, their ectoparasites and associated bacteria. The results presented could inform models of pathogen transmission in these bat populations and increase our theoretical understanding of community ecology in host–microbe systems.

Published
2024
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43. Mimicking non-ideal instrument behavior for hologram processing using neural style translation

Author

Schreck, John S., Hayman, Matthew, Gantos, Gabrielle, Bansemer, Aaron, and Gagne, David John

Subjects
Physics - Instrumentation and Detectors, Computer Science - Computer Vision and Pattern Recognition
Abstract

Holographic cloud probes provide unprecedented information on cloud particle density, size and position. Each laser shot captures particles within a large volume, where images can be computationally refocused to determine particle size and shape. However, processing these holograms, either with standard methods or with machine learning (ML) models, requires considerable computational resources, time and occasional human intervention. ML models are trained on simulated holograms obtained from the physical model of the probe since real holograms have no absolute truth labels. Using another processing method to produce labels would be subject to errors that the ML model would subsequently inherit. Models perform well on real holograms only when image corruption is performed on the simulated images during training, thereby mimicking non-ideal conditions in the actual probe (Schreck et. al, 2022). Optimizing image corruption requires a cumbersome manual labeling effort. Here we demonstrate the application of the neural style translation approach (Gatys et. al, 2016) to the simulated holograms. With a pre-trained convolutional neural network (VGG-19), the simulated holograms are ``stylized'' to resemble the real ones obtained from the probe, while at the same time preserving the simulated image ``content'' (e.g. the particle locations and sizes). Two image similarity metrics concur that the stylized images are more like real holograms than the synthetic ones. With an ML model trained to predict particle locations and shapes on the stylized data sets, we observed comparable performance on both simulated and real holograms, obviating the need to perform manual labeling. The described approach is not specific to hologram images and could be applied in other domains for capturing noise and imperfections in observational instruments to make simulated data more like real world observations., Comment: 23 pages, 9 figures

Published
2023
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44. Epidemiological Agent-Based Modelling Software (Epiabm)

Author

Gallagher, Kit, Bouros, Ioana, Fan, Nicholas, Hayman, Elizabeth, Heirene, Luke, Lamirande, Patricia, Lemenuel-Diot, Annabelle, Lambert, Ben, Gavaghan, David, and Creswell, Richard

Subjects
Quantitative Biology - Populations and Evolution, Quantitative Biology - Quantitative Methods
Abstract

Epiabm is a fully tested, open-source software package for epidemiological agent-based modelling, re-implementing the well-known CovidSim model from the MRC Centre for Global Infectious Disease Analysis at Imperial College London. It has been developed as part of the first-year training programme in the EPSRC SABS:R3 Centre for Doctoral Training at the University of Oxford. The model builds an age-stratified, spatially heterogeneous population and offers a modular approach to configure and run epidemic scenarios, allowing for a broad scope of investigative and comparative studies. Two simulation backends are provided: a pedagogical Python backend (with full functionality) and a high performance C++ backend for use with larger population simulations. Both are highly modular, with comprehensive testing and documentation for ease of understanding and extensibility. Epiabm is publicly available through GitHub at https://github.com/SABS-R3-Epidemiology/epiabm., Comment: Submitted to Journal of Open Research Software

Published
2022
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45. Previous education experience impacts student expectation and initial experience of transitioning into higher education

Author

Matthew A. Timmis, Angela Hibbs, Remco Polman, Rick Hayman, and David Stephens

Subjects
higher education, transition, expectation, sport and exercise science, further education, Education (General), L7-991
Abstract

IntroductionEntering higher education (HE) is one of the most significant transitions in a student’s life and is negatively impacted by any disparity between expectation and initial experience when joining their course.MethodThe current study explored how the students’ experiences of learning and teaching practices in their previous educational environment influenced their expectations and initial experiences of HE. The study adopted a mixed methods approach, initially surveying 69 students concerning their previous educational experiences, expectations and experiences of HE. Informed by the questions in the survey, two semi-structured focus groups comprising a total of 6 students were completed and analysed using inductive thematic analysis.Results and discussionThe current research identified specific challenges students face as they transition into HE, often resulting in an initial culture shock as that adapt to their new learning environment. These challenges are, to some extent, a consequence of their previous learning environment. Whilst expectations of HE were cultivated in their previous educational environment, they were not always accurate and resulted in a mismatch between expectation and reality of HE. This article identifies what may be missing for a student as they transition from further education into HE, and explores some of the opportunities HE faces in addressing these deficits.

Published
2024
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46. Pregnancy mobile app use: A survey of health information practices and quality awareness among pregnant women in Australia

Author

Bonnie R Brammall, Melanie J Hayman, and Cheryce L Harrison

Subjects
Medicine
Abstract

Background: Health-related mobile applications (apps) have the potential to improve health knowledge and promote healthy behaviours during pregnancy. Pregnancy apps are popular and extensively used by consumers. Objective: This study investigates the usage patterns, decision-making criteria and concerns regarding the quality and credibility of health-related information within pregnancy mobile applications. The aim of this study is to understand consumer perspectives to potentially contribute to guidelines for apps containing health-related information. Design: A cross-sectional study, utilising an online questionnaire for data collection. Methods: The study surveyed pregnant women in Australia who were recruited via online platforms, including social media and paid Facebook ads. Participants completed a 29-item questionnaire assessing their use of pregnancy apps, sources of health information and perceptions of app quality and safety, with data collected and analysed using the Qualtrics platform and SPSS Statistics. Results: The survey was survey completed by 427 current-or-recently pregnant individuals, aged 18 or over and located in Australia. Overall, 62.3% were currently pregnant and 37.7% were recently pregnant, within 6 months. Medical practitioners were the primary source of pregnancy-related health information, and pregnancy apps were the third most common source. Pregnancy apps were considered to be a trustworthy source of information by 63.8% of respondents and the majority used apps during pregnancy (94.2%). Of those who used pregnancy apps ( n = 325), information being safe and trustworthy was their top priority when selecting an app. However, 35.5% ( n = 115) had encountered information in an app they felt was unsafe or conflicted with previous knowledge or advice. Only 4.6% ( n = 15) were aware that health-related apps are not screened for accurate information/undergo quality assurance checks before being made available to download. If provided with a guide to evaluate app quality, 74.6% ( n = 241) would utilise the tool. Conclusions: These findings highlight a need to promote the critical assessment of health information within pregnancy apps and to develop resources to support consumers in doing so.

Published
2024
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47. Recent advances in applications, antimicrobial, cytotoxic activities and their associated mechanism of green silver nanoparticles: A review

Author

Tavga Sulaiman Rashid, Yaseen Galali, Hayman Kakakhan Awla, and S. Mohammad Sajadi

Subjects
Ag NPs, Green Synthesis, Production Mechanism, Biological Activities, Chemistry, QD1-999
Abstract

Apart from antibiotic resistance, the increasing incidence of cancers is among the serious health challenges facing humans today around the world. These indeed need new and environmentally friendly solutions. In this respect, synthesis and application of nanoparticles simply AgNPs have become of compelling interest within the last few years, especially within the area of biomedicine. The green synthesis of AgNPs using plant extracts is one of the promising eco-friendly methods that has treated microbial infections and acted against cancerous activities. A literature search on databases Web of Science, PubMed, and Scopus was performed between January 2023 and October 2023 in light of PRISMA. Afterward, screening for articles by title and abstract was implemented. Then, retrieved eligible studies were assessed for full-text inclusion criteria analysis. The reviewed findings show that AgNPs have contributed to health-related applications in the development of consumer goods like UV-resistant ointments and cosmetics. Their biomedical application is huge, especially regarding developing diagnosis devices for viruses such as Ebola, yellow fever, and Dengue. AgNPs thereby exhibited formidable antimicrobial action against a wide array of pathogenic microorganisms, each representing Gram-positive and Gram-negative bacteria. It proved to be effective even against antibiotic-resistant strains and pathogenic fungi. Besides this, their anticancer potentialities are quite extraordinary. In short, all these studies have given evidence for outstanding antimicrobial and anticancer efficiencies of biologically synthesized AgNPs to combat some of the serious health issues of the modern era.

Published
2024
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48. Stratified analyses refine association between TLR7 rare variants and severe COVID-19

Author

Jannik Boos, Caspar I. van der Made, Gayatri Ramakrishnan, Eamon Coughlan, Rosanna Asselta, Britt-Sabina Löscher, Luca V.C. Valenti, Rafael de Cid, Luis Bujanda, Antonio Julià, Erola Pairo-Castineira, J. Kenneth Baillie, Sandra May, Berina Zametica, Julia Heggemann, Agustín Albillos, Jesus M. Banales, Jordi Barretina, Natalia Blay, Paolo Bonfanti, Maria Buti, Javier Fernandez, Sara Marsal, Daniele Prati, Luisa Ronzoni, Nicoletta Sacchi, Joachim L. Schultze, Olaf Riess, Andre Franke, Konrad Rawlik, David Ellinghaus, Alexander Hoischen, Axel Schmidt, Kerstin U. Ludwig, Valeria Rimoldi, Elvezia M. Paraboschi, Alessandra Bandera, Flora Peyvandi, Giacomo Grasselli, Francesco Blasi, Francesco Malvestiti, Serena Pelusi, Cristiana Bianco, Lorenzo Miano, Angela Lombardi, Pietro Invernizzi, Alessio Gerussi, Giuseppe Citerio, Andrea Biondi, Maria Grazia Valsecchi, Marina Elena Cazzaniga, Giuseppe Foti, Ilaria Beretta, Mariella D'Angiò, Laura Rachele Bettini, Xavier Farré, Susana Iraola-Guzmán, Manolis Kogevinas, Gemma Castaño-Vinyals, Koldo Garcia-Etxebarria, Beatriz Nafria, Mauro D'Amato, Adriana Palom, Colin Begg, Sara Clohisey, Charles Hinds, Peter Horby, Julian Knight, Lowell Ling, David Maslove, Danny McAuley, Johnny Millar, Hugh Montgomery, Alistair Nichol, Peter J.M. Openshaw, Alexandre C. Pereira, Chris P. Ponting, Kathy Rowan, Malcolm G. Semple, Manu Shankar-Hari, Charlotte Summers, Timothy Walsh, Latha Aravindan, Ruth Armstrong, Heather Biggs, Ceilia Boz, Adam Brown, Richard Clark, Audrey Coutts, Judy Coyle, Louise Cullum, Sukamal Das, Nicky Day, Lorna Donnelly, Esther Duncan, Angie Fawkes, Paul Fineran, Max Head Fourman, Anita Furlong, James Furniss, Bernadette Gallagher, Tammy Gilchrist, Ailsa Golightly, Fiona Griffiths, Katarzyna Hafezi, Debbie Hamilton, Ross Hendry, Andy Law, Dawn Law, Rachel Law, Sarah Law, Rebecca Lidstone-Scott, Louise Macgillivray, Alan Maclean, Hanning Mal, Sarah McCafferty, Ellie Mcmaster, Jen Meikle, Shona C. Moore, Kirstie Morrice, Lee Murphy, Sheena Murphy, Mybaya Hellen, Wilna Oosthuyzen, Chenqing Zheng, Jiantao Chen, Nick Parkinson, Trevor Paterson, Katherine Schon, Andrew Stenhouse, Mihaela Das, Maaike Swets, Helen Szoor-McElhinney, Filip Taneski, Lance Turtle, Tony Wackett, Mairi Ward, Jane Weaver, Nicola Wrobel, Marie Zechner, Gill Arbane, Aneta Bociek, Sara Campos, Neus Grau, Tim Owen Jones, Rosario Lim, Martina Marotti, Marlies Ostermann, Christopher Whitton, Zoe Alldis, Raine Astin-Chamberlain, Fatima Bibi, Jack Biddle, Sarah Blow, Matthew Bolton, Catherine Borra, Ruth Bowles, Maudrian Burton, Yasmin Choudhury, David Collier, Amber Cox, Amy Easthope, Patrizia Ebano, Stavros Fotiadis, Jana Gurasashvili, Rosslyn Halls, Pippa Hartridge, Delordson Kallon, Jamila Kassam, Ivone Lancoma-Malcolm, Maninderpal Matharu, Peter May, Oliver Mitchelmore, Tabitha Newman, Mital Patel, Jane Pheby, Irene Pinzuti, Zoe Prime, Oleksandra Prysyazhna, Julian Shiel, Melanie Taylor, Carey Tierney, Suzanne Wood, Anne Zak, Olivier Zongo, Stephen Bonner, Keith Hugill, Jessica Jones, Steven Liggett, Evie Headlam, Nageswar Bandla, Minnie Gellamucho, Michelle Davies, Christopher Thompson, Marwa Abdelrazik, Dhanalakshmi Bakthavatsalam, Munzir Elhassan, Arunkumar Ganesan, Anne Haldeos, Jeronimo Moreno-Cuesta, Dharam Purohit, Rachel Vincent, Kugan Xavier, Kumar Rohit, Frater Alasdair, Malik Saleem, Carter David, Jenkins Samuel, Zoe Lamond, Wall Alanna, Jaime Fernandez-Roman, David O. Hamilton, Emily Johnson, Brian Johnston, Maria Lopez Martinez, Suleman Mulla, David Shaw, Alicia A.C. Waite, Victoria Waugh, Ingeborg D. Welters, Karen Williams, Anna Cavazza, Maeve Cockrell, Eleanor Corcoran, Maria Depante, Clare Finney, Ellen Jerome, Mark McPhail, Monalisa Nayak, Harriet Noble, Kevin O'Reilly, Evita Pappa, Rohit Saha, Sian Saha, John Smith, Abigail Knighton, David Antcliffe, Dorota Banach, Stephen Brett, Phoebe Coghlan, Ziortza Fernandez, Anthony Gordon, Roceld Rojo, Sonia Sousa Arias, Maie Templeton, Megan Meredith, Lucy Morris, Lucy Ryan, Amy Clark, Julia Sampson, Cecilia Peters, Martin Dent, Margaret Langley, Saima Ashraf, Shuying Wei, Angela Andrew, Archana Bashyal, Neil Davidson, Paula Hutton, Stuart McKechnie, Jean Wilson, David Baptista, Rebecca Crowe, Rita Fernandes, Rosaleen Herdman-Grant, Anna Joseph, Denise O'Connor, Meryem Allen, Adam Loveridge, India McKenley, Eriko Morino, Andres Naranjo, Richard Simms, Kathryn Sollesta, Andrew Swain, Harish Venkatesh, Jacyntha Khera, Jonathan Fox, Gillian Andrew, Lucy Barclay, Marie Callaghan, Rachael Campbell, Sarah Clark, Dave Hope, Lucy Marshall, Corrienne McCulloch, Kate Briton, Jo Singleton, Sohphie Birch, Lutece Brimfield, Zoe Daly, David Pogson, Steve Rose, Ceri Battle, Elaine Brinkworth, Rachel Harford, Carl Murphy, Luke Newey, Tabitha Rees, Marie Williams, Sophie Arnold, Petra Polgarova, Katerina Stroud, Eoghan Meaney, Megan Jones, Anthony Ng, Shruti Agrawal, Nazima Pathan, Deborah White, Esther Daubney, Kay Elston, Lina Grauslyte, Musarat Hussain, Mandeep Phull, Tatiana Pogreban, Lace Rosaroso, Erika Salciute, George Franke, Joanna Wong, Aparna George, Laura Ortiz-Ruiz de Gordoa, Emily Peasgood, Claire Phillips, Michelle Bates, Jo Dasgin, Jaspret Gill, Annette Nilsson, James Scriven, Carlos Castro Delgado, Deborah Dawson, Lijun Ding, Georgia Durrant, Obiageri Ezeobu, Sarah Farnell-Ward, Abiola Harrison, Rebecca Kanu, Susannah Leaver, Elena Maccacari, Soumendu Manna, Romina Pepermans Saluzzio, Joana Queiroz, Tinashe Samakomva, Christine Sicat, Joana Texeira, Edna Fernandes Da Gloria, Ana Lisboa, John Rawlins, Jisha Mathew, Ashley Kinch, William James Hurt, Nirav Shah, Victoria Clark, Maria Thanasi, Nikki Yun, Kamal Patel, Sara Bennett, Emma Goodwin, Matthew Jackson, Alissa Kent, Clare Tibke, Wiesia Woodyatt, Ahmed Zaki, Azmerelda Abraheem, Peter Bamford, Kathryn Cawley, Charlie Dunmore, Maria Faulkner, Rumanah Girach, Helen Jeffrey, Rhianna Jones, Emily London, Imrun Nagra, Farah Nasir, Hannah Sainsbury, Clare Smedley, Tahera Patel, Matthew Smith, Srikanth Chukkambotla, Aayesha Kazi, Janice Hartley, Joseph Dykes, Muhammad Hijazi, Sarah Keith, Meherunnisa Khan, Janet Ryan-Smith, Philippa Springle, Jacqueline Thomas, Nick Truman, Samuel Saad, Dabheoc Coleman, Christopher Fine, Roseanna Matt, Bethan Gay, Jack Dalziel, Syamlan Ali, Drew Goodchild, Rhiannan Harling, Ravi Bhatterjee, Wendy Goddard, Chloe Davison, Stephen Duberly, Jeanette Hargreaves, Rachel Bolton, Miriam Davey, David Golden, Rebecca Seaman, Shiney Cherian, Sean Cutler, Anne Emma Heron, Anna Roynon-Reed, Tamas Szakmany, Gemma Williams, Owen Richards, Yusuf Cheema, Hollie Brooke, Sarah Buckley, Jose Cebrian Suarez, Ruth Charlesworth, Karen Hansson, John Norris, Alice Poole, Alastair Rose, Rajdeep Sandhu, Brendan Sloan, Elizabeth Smithson, Muthu Thirumaran, Veronica Wagstaff, Alexandra Metcalfe, Mark Brunton, Jess Caterson, Holly Coles, Matthew Frise, Sabi Gurung Rai, Nicola Jacques, Liza Keating, Emma Tilney, Shauna Bartley, Parminder Bhuie, Sian Gibson, Amanda Lyle, Fiona McNeela, Jayachandran Radhakrishnan, Alistair Hughes, Bryan Yates, Jessica Reynolds, Helen Campbell, Maria Thompsom, Steve Dodds, Stacey Duffy, Sandra Greer, Karen Shuker, Ascanio Tridente, Reena Khade, Ashok Sundar, George Tsinaslanidis, Isobel Birkinshaw, Joseph Carter, Kate Howard, Joanne Ingham, Rosie Joy, Harriet Pearson, Samantha Roche, Zoe Scott, Hollie Bancroft, Mary Bellamy, Margaret Carmody, Jacqueline Daglish, Faye Moore, Joanne Rhodes, Mirriam Sangombe, Salma Kadiri, Maria Croft, Ian White, Victoria Frost, Maia Aquino, Rajeev Jha, Vinodh Krishnamurthy, Lai Lim, Li Lim, Edward Combes, Teishel Joefield, Sonja Monnery, Valerie Beech, Sallyanne Trotman, Christine Almaden-Boyle, Pauline Austin, Louise Cabrelli, Stephen Cole, Matt Casey, Susan Chapman, Clare Whyte, Yolanda Baird, Aaron Butler, Indra Chadbourn, Linda Folkes, Heather Fox, Amy Gardner, Raquel Gomez, Gillian Hobden, Luke Hodgson, Kirsten King, Michael Margarson, Tim Martindale, Emma Meadows, Dana Raynard, Yvette Thirlwall, David Helm, Jordi Margalef, Kristine Criste, Rebecca Cusack, Kim Golder, Hannah Golding, Oliver Jones, Samantha Leggett, Michelle Male, Martyna Marani, Kirsty Prager, Toran Williams, Belinda Roberts, Karen Salmon, Peter Anderson, Katie Archer, Karen Austin, Caroline Davis, Alison Durie, Olivia Kelsall, Jessica Thrush, Charlie Vigurs, Laura Wild, Hannah-Louise Wood, Helen Tranter, Alison Harrison, Nicholas Cowley, Michael McAlindon, Andrew Burtenshaw, Stephen Digby, Emma Low, Aled Morgan, Naiara Cother, Tobias Rankin, Sarah Clayton, Alex McCurdy, Cecilia Ahmed, Balvinder Baines, Sarah Clamp, Julie Colley, Risna Haq, Anne Hayes, Jonathan Hulme, Samia Hussain, Sibet Joseph, Rita Kumar, Zahira Maqsood, Manjit Purewal, Leonie Benham, Zena Bradshaw, Joanna Brown, Melanie Caswell, Jason Cupitt, Sarah Melling, Stephen Preston, Nicola Slawson, Emma Stoddard, Scott Warden, Bethan Deacon, Ceri Lynch, Carla Pothecary, Lisa Roche, Gwenllian Sera Howe, Jayaprakash Singh, Keri Turner, Hannah Ellis, Natalie Stroud, Jodie Hunt, Joy Dearden, Emma Dobson, Andy Drummond, Michelle Mulcahy, Sheila Munt, Grainne O'Connor, Jennifer Philbin, Chloe Rishton, Redmond Tully, Sarah Winnard, Susanne Cathcart, Katharine Duffy, Alex Puxty, Kathryn Puxty, Lynne Turner, Jane Ireland, Gary Semple, Kate Long, Simon Whiteley, Elizabeth Wilby, Bethan Ogg, Amanda Cowton, Andrea Kay, Melanie Kent, Kathryn Potts, Ami Wilkinson, Suzanne Campbell, Ellen Brown, Julie Melville, Jay Naisbitt, Rosane Joseph, Maria Lazo, Olivia Walton, Alan Neal, Peter Alexander, Schvearn Allen, Joanne Bradley-Potts, Craig Brantwood, Jasmine Egan, Timothy Felton, Grace Padden, Luke Ward, Stuart Moss, Susannah Glasgow, Lynn Abel, Michael Brett, Brian Digby, Lisa Gemmell, James Hornsby, Patrick MacGoey, Pauline O'Neil, Richard Price, Natalie Rodden, Kevin Rooney, Radha Sundaram, Nicola Thomson, Bridget Hopkins, Laura Thrasyvoulou, Heather Willis, Martyn Clark, Martina Coulding, Edward Jude, Jacqueline McCormick, Oliver Mercer, Darsh Potla, Hafiz Rehman, Heather Savill, Victoria Turner, Charlotte Downes, Kathleen Holding, Katie Riches, Mary Hilton, Mel Hayman, Deepak Subramanian, Priya Daniel, Oluronke Adanini, Nikhil Bhatia, Maines Msiska, Rebecca Collins, Ian Clement, Bijal Patel, A. Gulati, Carole Hays, K. Webster, Anne Hudson, Andrea Webster, Elaine Stephenson, Louise McCormack, Victoria Slater, Rachel Nixon, Helen Hanson, Maggie Fearby, Sinead Kelly, Victoria Bridgett, Philip Robinson, Julie Camsooksai, Charlotte Humphrey, Sarah Jenkins, Henrik Reschreiter, Beverley Wadams, Yasmin Death, Victoria Bastion, Daphene Clarke, Beena David, Harriet Kent, Rachel Lorusso, Gamu Lubimbi, Sophie Murdoch, Melchizedek Penacerrada, Alastair Thomas, Jennifer Valentine, Ana Vochin, Retno Wulandari, Brice Djeugam, Gillian Bell, Katy English, Amro Katary, Louise Wilcox, Michelle Bruce, Karen Connolly, Tracy Duncan, Helen T-Michael, Gabriella Lindergard, Samuel Hey, Claire Fox, Jordan Alfonso, Laura Jayne Durrans, Jacinta Guerin, Bethan Blackledge, Jade Harris, Martin Hruska, Ayaa Eltayeb, Thomas Lamb, Tracey Hodgkiss, Lisa Cooper, Joanne Rothwell, Angela Allan, Felicity Anderson, Callum Kaye, Jade Liew, Jasmine Medhora, Teresa Scott, Erin Trumper, Adriana Botello, Liana Lankester, Nikitas Nikitas, Colin Wells, Bethan Stowe, Kayleigh Spencer, Craig Brandwood, Lara Smith, Katie Birchall, Laurel Kolakaluri, Deborah Baines, Anila Sukumaran, Elena Apetri, Cathrine Basikolo, Laura Catlow, Bethan Charles, Paul Dark, Reece Doonan, Alice Harvey, Daniel Horner, Karen Knowles, Stephanie Lee, Diane Lomas, Chloe Lyons, Tracy Marsden, Danielle McLaughlan, Liam McMorrow, Jessica Pendlebury, Jane Perez, Maria Poulaka, Nicola Proudfoot, Melanie Slaughter, Kathryn Slevin, Vicky Thomas, Danielle Walker, Angiy Michael, Matthew Collis, Tracey Cosier, Gemma Millen, Neil Richardson, Natasha Schumacher, Heather Weston, James Rand, Nicola Baxter, Steven Henderson, Sophie Kennedy-Hay, Christopher McParland, Laura Rooney, Malcolm Sim, Gordan McCreath, Louise Akeroyd, Shereen Bano, Matt Bromley, Lucy Gurr, Tom Lawton, James Morgan, Kirsten Sellick, Deborah Warren, Brian Wilkinson, Janet McGowan, Camilla Ledgard, Amelia Stacey, Kate Pye, Ruth Bellwood, Michael Bentley, Jeremy Bewley, Zoe Garland, Lisa Grimmer, Bethany Gumbrill, Rebekah Johnson, Katie Sweet, Denise Webster, Georgia Efford, Karen Convery, Deirdre Fottrell-Gould, Lisa Hudig, Jocelyn Keshet-Price, Georgina Randell, Katie Stammers, Maria Bokhari, Vanessa Linnett, Rachael Lucas, Wendy McCormick, Jenny Ritzema, Amanda Sanderson, Helen Wild, Anthony Rostron, Alistair Roy, Lindsey Woods, Sarah Cornell, Fiona Wakinshaw, Kimberley Rogerson, Jordan Jarmain, Robert Parker, Amie Reddy, Ian Turner-Bone, Laura Wilding, Peter Harding, Caroline Abernathy, Louise Foster, Andrew Gratrix, Vicky Martinson, Priyai Parkinson, Elizabeth Stones, Llucia Carbral-Ortega, Georgia Bercades, David Brealey, Ingrid Hass, Niall MacCallum, Gladys Martir, Eamon Raith, Anna Reyes, Deborah Smyth, Letizia Zitter, Sarah Benyon, Suzie Marriott, Linda Park, Samantha Keenan, Elizabeth Gordon, Helen Quinn, Kizzy Baines, Lenka Cagova, Adama Fofano, Lucie Garner, Helen Holcombe, Sue Mepham, Alice Michael Mitchell, Lucy Mwaura, Krithivasan Praman, Alain Vuylsteke, Julie Zamikula, Bally Purewal, Vanessa Rivers, Stephanie Bell, Hayley Blakemore, Borislava Borislavova, Beverley Faulkner, Emma Gendall, Elizabeth Goff, Kati Hayes, Matt Thomas, Ruth Worner, Kerry Smith, Deanna Stephens, Louise Mew, Esther Mwaura, Richard Stewart, Felicity Williams, Lynn Wren, Sara-Beth Sutherland, Emily Bevan, Jane Martin, Dawn Trodd, Geoff Watson, Caroline Wrey Brown, Amy Collins, Waqas Khaliq, Estefania Treus Gude, Olugbenga Akinkugbe, Alasdair Bamford, Emily Beech, Holly Belfield, Michael Bell, Charlene Davies, Gareth A.L. Jones, Tara McHugh, Hamza Meghari, Lauran O'Neill, Mark J. Peters, Samiran Ray, Ana Luisa Tomas, Iona Burn, Geraldine Hambrook, Katarina Manso, Ruth Penn, Pradeep Shanmugasundaram, Julie Tebbutt, Danielle Thornton, Jade Cole, Rhys Davies, Donna Duffin, Helen Hill, Ben Player, Emma Thomas, Angharad Williams, Denise Griffin, Nycola Muchenje, Mcdonald Mupudzi, Richard Partridge, Jo-Anna Conyngham, Rachel Thomas, Mary Wright, Maria Alvarez Corral, Reni Jacob, Cathy Jones, Craig Denmade, Sarah Beavis, Katie Dale, Rachel Gascoyne, Joanne Hawes, Kelly Pritchard, Lesley Stevenson, Amanda Whileman, Patricia Doble, Joanne Hutter, Corinne Pawley, Charmaine Shovelton, Marius Vaida, Deborah Butcher, Susie O'Sullivan, Nicola Butterworth-Cowin, Norfaizan Ahmad, Joann Barker, Kris Bauchmuller, Sarah Bird, Kay Cawthron, Kate Harrington, Yvonne Jackson, Faith Kibutu, Becky Lenagh, Shamiso Masuko, Gary H. Mills, Ajay Raithatha, Matthew Wiles, Jayne Willson, Helen Newell, Alison Lye, Lorenza Nwafor, Claire Jarman, Sarah Rowland-Jones, David Foote, Joby Cole, Roger Thompson, James Watson, Lisa Hesseldon, Irene Macharia, Luke Chetam, Jacqui Smith, Amber Ford, Samantha Anderson, Kathryn Birchall, Kay Housley, Sara Walker, Leanne Milner, Helena Hanratty, Helen Trower, Patrick Phillips, Simon Oxspring, Ben Donne, Catherine Jardine, Dewi Williams, Alasdair Hay, Rebecca Flanagan, Gareth Hughes, Scott Latham, Emma McKenna, Jennifer Anderson, Robert Hull, Kat Rhead, Carina Cruz, Natalie Pattison, Rob Charnock, Denise McFarland, Denise Cosgrove, Ashar Ahmed, Anna Morris, Srinivas Jakkula, Asifa Ali, Megan Brady, Sam Dale, Annalisa Dance, Lisa Gledhill, Jill Greig, Kathryn Hanson, Kelly Holdroyd, Marie Home, Diane Kelly, Ross Kitson, Lear Matapure, Deborah Melia, Samantha Mellor, Tonicha Nortcliffe, Jez Pinnell, Matthew Robinson, Lisa Shaw, Ryan Shaw, Lesley Thomis, Alison Wilson, Tracy Wood, Lee-Ann Bayo, Ekta Merwaha, Tahira Ishaq, Sarah Hanley, Meg Hibbert, Dariusz Tetla, Chrsitopher Woodford, Latha Durga, Gareth Kennard-Holden, Debbie Branney, Jordan Frankham, Sally Pitts, Nigel White, Shondipon Laha, Mark Verlander, Alexandra Williams, Abdelhakim Altabaibeh, Ana Alvaro, Kayleigh Gilbert, Louise Ma, Loreta Mostoles, Chetan Parmar, Kathryn Simpson, Champa Jetha, Lauren Booker, Anezka Pratley, Colene Adams, Anita Agasou, Tracie Arden, Amy Bowes, Pauline Boyle, Mandy Beekes, Heather Button, Nigel Capps, Mandy Carnahan, Anne Carter, Danielle Childs, Denise Donaldson, Kelly Hard, Fran Hurford, Yasmin Hussain, Ayesha Javaid, James Jones, Sanal Jose, Michael Leigh, Terry Martin, Helen Millward, Nichola Motherwell, Rachel Rikunenko, Jo Stickley, Julie Summers, Louise Ting, Helen Tivenan, Louise Tonks, Rebecca Wilcox, Maureen Holland, Natalie Keenan, Marc Lyons, Helen Wassall, Chris Marsh, Mervin Mahenthran, Emma Carter, Thomas Kong, Helen Blackman, Ben Creagh-Brown, Sinead Donlon, Natalia Michalak-Glinska, Sheila Mtuwa, Veronika Pristopan, Armorel Salberg, Eleanor Smith, Sarah Stone, Charles Piercy, Jerik Verula, Dorota Burda, Rugia Montaser, Lesley Harden, Irving Mayangao, Cheryl Marriott, Paul Bradley, Celia Harris, Susan Anderson, Eleanor Andrews, Janine Birch, Emma Collins, Kate Hammerton, Ryan O'Leary, Michele Clark, Sarah Purvis, Russell Barber, Claire Hewitt, Annette Hilldrith, Karen Jackson-Lawrence, Sarah Shepardson, Maryanne Wills, Susan Butler, Silvia Tavares, Amy Cunningham, Julia Hindale, Sarwat Arif, Sarah Bean, Karen Burt, Michael Spivey, Carrie Demetriou, Charlotte Eckbad, Sarah Hierons, Lucy Howie, Sarah Mitchard, Lidia Ramos, Alfredo Serrano-Ruiz, Katie White, Fiona Kelly, Daniele Cristiano, Natalie Dormand, Zohreh Farzad, Mahitha Gummadi, Kamal Liyanage, Brijesh Patel, Sara Salmi, Geraldine Sloane, Vicky Thwaites, Mathew Varghese, Anelise C. Zborowski, John Allan, Tim Geary, Gordon Houston, Alistair Meikle, Peter O'Brien, Miranda Forsey, Agilan Kaliappan, Anne Nicholson, Joanne Riches, Mark Vertue, Elizabeth Allan, Kate Darlington, Ffyon Davies, Jack Easton, Sumit Kumar, Richard Lean, Daniel Menzies, Richard Pugh, Xinyi Qiu, Llinos Davies, Hannah Williams, Jeremy Scanlon, Gwyneth Davies, Callum Mackay, Joannne Lewis, Stephanie Rees, Metod Oblak, Monica Popescu, Mini Thankachen, Andrew Higham, Kerry Simpson, Jayne Craig, Rosie Baruah, Sheila Morris, Susie Ferguson, Amy Shepherd, Luke Stephen Prockter Moore, Marcela Paola Vizcaychipi, Laura Gomes de Almeida Martins, Jaime Carungcong, Inthakab Ali Mohamed Ali, Karen Beaumont, Mark Blunt, Zoe Coton, Hollie Curgenven, Mohamed Elsaadany, Kay Fernandes, Sameena Mohamed Ally, Harini Rangarajan, Varun Sarathy, Sivarupan Selvanayagam, Dave Vedage, Matthew White, Mandy Gill, Paul Paul, Valli Ratnam, Sarah Shelton, Inez Wynter, Siobhain Carmody, Valerie Joan Page, Claire Marie Beith, Karen Black, Suzanne Clements, Alan Morrison, Dominic Strachan, Margaret Taylor, Michelle Clarkson, Stuart D'Sylva, Kathryn Norman, Fiona Auld, Joanne Donnachie, Ian Edmond, Lynn Prentice, Nikole Runciman, Dario Salutous, Lesley Symon, Anne Todd, Patricia Turner, Abigail Short, Laura Sweeney, Euan Murdoch, Dhaneesha Senaratne, Michaela Hill, Thogulava Kannan, Wild Laura, Rikki Crawley, Abigail Crew, Mishell Cunningham, Allison Daniels, Laura Harrison, Susan Hope, Ken Inweregbu, Sian Jones, Nicola Lancaster, Jamie Matthews, Alice Nicholson, Gemma Wray, Helen Langton, Rachel Prout, Malcolm Watters, Catherine Novis, Anthony Barron, Ciara Collins, Sundeep Kaul, Heather Passmore, Claire Prendergast, Anna Reed, Paula Rogers, Rajvinder Shokkar, Meriel Woodruff, Hayley Middleton, Oliver Polgar, Claire Nolan, Kanta Mahay, Dawn Collier, Anil Hormis, Victoria Maynard, Cheryl Graham, Rachel Walker, Ellen Knights, Alicia Price, Alice Thomas, Chris Thorpe, Teresa Behan, Caroline Burnett, Jonathan Hatton, Elaine Heeney, Atideb Mitra, Maria Newton, Rachel Pollard, Rachael Stead, Vishal Amin, Elena Anastasescu, Vikram Anumakonda, Komala Karthik, Rizwana Kausar, Karen Reid, Jacqueline Smith, Janet Imeson-Wood, Denise Skinner, Jane Gaylard, Dee Mullan, Julie Newman, Alison Brown, Vikki Crickmore, Gabor Debreceni, Joy Wilkins, Liz Nicol, Rosie Reece-Anthony, Mark Birt, Alison Ghosh, Emma Williams, Louise Allen, Eva Beranova, Nikki Crisp, Joanne Deery, Tracy Hazelton, Alicia Knight, Carly Price, Sorrell Tilbey, Salah Turki, Sharon Turney, Joshua Cooper, Cheryl Finch, Sarah Liderth, Alison Quinn, Natalia Waddington, Tina Coventry, Susan Fowler, Michael MacMahon, Amanda McGregor, Anne Cowley, Judith Highgate, Jane Gregory, Susan O'Connell, Tim Smith, Luigi Barberis, Shameer Gopal, Nichola Harris, Victoria Lake, Stella Metherell, Elizabeth Radford, Amelia Daniel, Joanne Finn, Rajnish Saha, Nikki White, Phil Donnison, Fiona Trim, Beena Eapen, Jenny Birch, Laura Bough, Josie Goodsell, Rebecca Tutton, Patricia Williams, Sarah Williams, Barbara Winter-Goodwin, Ailstair Nichol, Kathy Brickell, Michelle Smyth, Lorna Murphy, Samantha Coetzee, Alistair Gales, Igor Otahal, Meena Raj, Craig Sell, Paula Hilltout, Jayne Evitts, Amanda Tyler, Joanne Waldron, Kate Beesley, Sarah Board, Agnieszka Kubisz-Pudelko, Alison Lewis, Jess Perry, Lucy Pippard, Di Wood, Clare Buckley, Peter Barry, Neil Flint, Patel Rekha, Dawn Hales, Lara Bunni, Claire Jennings, Monica Latif, Rebecca Marshall, Gayathri Subramanian, Peter J. McGuigan, Christopher Wasson, Stephanie Finn, Jackie Green, Erin Collins, Bernadette King, Andy Campbell, Sara Smuts, Joseph Duffield, Oliver Smith, Lewis Mallon, Watkins Claire, Liam Botfield, Joanna Butler, Catherine Dexter, Jo Fletcher, Atul Garg, Aditya Kuravi, Poonam Ranga, Emma Virgilio, Zakaula Belagodu, Bridget Fuller, Anca Gherman, Olumide Olufuwa, Remi Paramsothy, Carmel Stuart, Naomi Oakley, Charlotte Kamundi, David Tyl, Katy Collins, Pedro Silva, June Taylor, Laura King, Charlotte Coates, Maria Crowley, Phillipa Wakefield, Jane Beadle, Laura Johnson, Janet Sargeant, Madeleine Anderson, Ailbhe Brady, Rebekah Chan, Jeff Little, Shane McIvor, Helena Prady, Helen Whittle, Bijoy Mathew, Ben Attwood, Penny Parsons, Geraldine Ward, Pamela Bremmer, West Joe, Baird Tracy, Ruddy Jim, Ellie Davies, Sonia Sathe, Catherine Dennis, Alastair McGregor, Victoria Parris, Sinduya Srikaran, Anisha Sukha, Noreen Clarke, Jonathan Whiteside, Mairi Mascarenhas, Avril Donaldson, Joanna Matheson, Fiona Barrett, Marianne O'Hara, Laura Okeefe, Clare Bradley, Christine Eastgate-Jackson, Helder Filipe, Daniel Martin, Amitaa Maharajh, Sara Mingo Garcia, Glykeria Pakou, Mark De Neef, Kathy Dent, Elizabeth Horsley, Muhmmad Nauman Akhtar, Sandra Pearson, Dorota Potoczna, Sue Spencer, Melanie Clapham, Rosemary Harper, Una Poultney, Polly Rice, Rachel Mutch, Lisa Armstrong, Hayley Bates, Emma Dooks, Fiona Farquhar, Brigid Hairsine, Chantal McParland, Sophie Packham, Rehana Bi, Barney Scholefield, Lydia Ashton, Linsha George, Sophie Twiss, David Wright, Manish Chablani, Amy Kirkby, Kimberley Netherton, Kim Davies, Linda O'Brien, Zohra Omar, Emma Perkins, Tracy Lewis, Isobel Sutherland, Karen Burns, Dr Ben Chandler, Kerry Elliott, Janine Mallinson, Alison Turnbull, Prisca Gondo, Bernard Hadebe, Abdul Kayani, Bridgett Masunda, Taya Anderson, Dan Hawcutt, Laura O'Malley, Laura Rad, Naomi Rogers, Paula Saunderson, Kathryn Sian Allison, Deborah Afolabi, Jennifer Whitbread, Dawn Jones, Rachael Dore, Matthew Halkes, Pauline Mercer, Lorraine Thornton, Joy Dawson, Sweyn Garrioch, Melanie Tolson, Jonathan Aldridge, Ritoo Kapoor, David Loader, Karen Castle, Sally Humphreys, Ruth Tampsett, Katherine Mackintosh, Amanda Ayers, Wendy Harrison, Julie North, Suzanne Allibone, Roman Genetu, Vidya Kasipandian, Amit Patel, Ainhi Mac, Anthony Murphy, Parisa Mahjoob, Roonak Nazari, Lucy Worsley, Andrew Fagan, Thomas Bemand, Ethel Black, Arnold Dela Rosa, Ryan Howle, Shaman Jhanji, Ravishankar Rao Baikady, Kate Colette Tatham, Benjamin Thomas, Dina Bell, Rosalind Boyle, Katie Douglas, Lynn Glass, Emma Lee, Liz Lennon, Austin Rattray, Abigail Taylor, Rachel Anne Hughes, Helen Thomas, Alun Rees, Michaela Duskova, Janet Phipps, Suzanne Brooks, Michelle Edwards, Sheena Quaid, Ekaterina Watson, Adam Brayne, Emma Fisher, Jane Hunt, Peter Jackson, Duncan Kaye, Nicholas Love, Juliet Parkin, Victoria Tuckey, Lynne Van Koutrik, Sasha Carter, Benedict Andrew, Louise Findlay, Katie Adams, Jen Service, Alison Williams, Claire Cheyne, Anne Saunderson, Sam Moultrie, Miranda Odam, Kathryn Hall, Isheunesu Mapfunde, Charlotte Willis, Alex Lyon, Chunda Sri-Chandana, Joslan Scherewode, Lorraine Stephenson, Sarah Marsh, John Hardy, Henry Houlden, Eleanor Moncur, Ambreen Tariq, Arianna Tucci, Maria Hobrok, Ronda Loosley, Heather McGuinness, Helen Tench, Rebecca Wolf-Roberts, Val Irvine, Benjamin Shelley, Claire Gorman, Abhinav Gupta, Elizabeth Timlick, Rebecca Brady, Barry Milligan, Arianna Bellini, Jade Bryant, Anton Mayer, Amy Pickard, Nicholas Roe, Jason Sowter, Alex Howlett, Katy Fidler, Emma Tagliavini, and Kevin Donnelly

Subjects
SARS-CoV-2, host genetics, toll-like receptor 7, targeted sequencing, rare variants, variant collapsing analysis, Genetics, QH426-470
Abstract

Summary: Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and 5,347 population-based controls from Spain/Italy. Rare deleterious TLR7 variants were present in 2.4% of young (

Published
2024
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49. Mapping threatened Thai bovids provides opportunities for improved conservation outcomes in Asia

Author

Wantida Horpiencharoen, Renata L. Muylaert, Jonathan C. Marshall, Reju Sam John, Antony J. Lynam, Alex Riggio, Alexander Godfrey, Dusit Ngoprasert, George A. Gale, Eric Ash, Francesco Bisi, Giacomo Cremonesi, Gopalasamy Reuben Clements, Marnoch Yindee, Nay Myo Shwe, Chanratana Pin, Thomas N. E. Gray, Saw Soe Aung, Seree Nakbun, Stephanie G. Manka, Robert Steinmetz, Rungnapa Phoonjampa, Naret Seuaturien, Worrapan Phumanee, and David T. S. Hayman

Subjects
species distribution, herbivores, large mammals, wildlife conservation, habitat suitability, protected areas, Science
Abstract

Wild bovids provide important ecosystem functions as seed dispersers and vegetation modifiers. Five wild bovids remain in Thailand: gaur (Bos gaurus), banteng (Bos javanicus), wild water buffalo (Bubalus arnee), mainland serow (Capricornis sumatraensis) and Chinese goral (Naemorhedus griseus). Their populations and habitats have declined substantially and become fragmented by land-use change. We use ecological niche models to quantify how much potential suitable habitat for these species remains within protected areas in Asia and then specifically Thailand. We combined species occurrence data from several sources (e.g. mainly camera traps and direct observation) with environmental variables and species-specific and single, large accessible areas in ensemble models to generate suitability maps, using out-of-sample predictions to validate model performance against new independent data. Gaur, banteng and buffalo models showed reasonable model accuracy throughout the entire distribution (greater than or equal to 62%) and in Thailand (greater than or equal to 80%), whereas serow and goral models performed poorly for the entire distribution and in Thailand, though 5 km movement buffers markedly improved the performance for serow. Large suitable areas were identified in Thailand and India for gaur, Cambodia and Thailand for banteng and India for buffalo. Over 50% of suitable habitat is located outside protected areas, highlighting the need for habitat management and conflict mitigation outside protected areas.

Published
2024
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50. Testing home-based exercise strategies in underserved minority cancer patients undergoing chemotherapy (THRIVE) trial: a study protocol

Author

Huimin Yan, Paola Gonzalo-Encabo, Rebekah L. Wilson, Cami N. Christopher, James D. Cannon, Dong-Woo Kang, John Gardiner, Michelle Perez, Mary K. Norris, Daniel Gundersen, Laura L. Hayman, Rachel A. Freedman, Timothy R. Rebbeck, Ling Shi, and Christina M. Dieli-Conwright

Subjects
cancer, racial and ethnic minorities, home-based exercise, exercise participation, cardiovascular risk factors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

BackgroundHigher rates of physical inactivity and comorbid conditions are reported in Hispanic/Latinx and Black cancer patients receiving chemotherapy compared to their White counterparts. Despite the beneficial effect of exercise training for cancer patients, rates of participation in exercise oncology clinical trials are low among disadvantaged and racial and ethnic minority groups. Here, we will examine the effect of an exercise intervention using a novel, accessible, and cost-effective home-based exercise approach among Hispanic/Latinx and Black cancer patients receiving chemotherapy on exercise participation and cardiovascular disease risk.MethodsThe THRIVE trial is an 8-month prospective, three-arm study of 45 patients who are randomized in a 1:1:1 fashion to a supervised exercise intervention (SUP), unsupervised exercise (UNSUP), or an attention control (AC) group. Eligible patients include those with breast, colorectal, or prostate cancer, who are sedentary, overweight or obese, self-identify as Hispanic/Latinx or Black, and plan to receive chemotherapy. Patients randomized to the SUP group participate in a home-based 16-week periodized aerobic and resistance exercise program performed three days per week, supervised through video conference technology. Patients randomized to the UNSUP group participate in an unsupervised 16-week, telehealth-based, periodized aerobic and resistance exercise program performed three days per week using the same exercise prescription parameters as the SUP group. Patients randomized to the AC group receive a 16-week home-based stretching program. The primary outcome is changes in minutes of physical activity assessed by 7-day accelerometry at post-intervention. Secondary outcomes include cardiovascular risk factors, patient-reported outcomes, and physical function. Outcome measures are tested at baseline, post-intervention at month 4, and after a non-intervention follow-up period at month 8.DiscussionThe THRIVE trial is the first study to employ a novel and potentially achievable exercise intervention for a minority population receiving chemotherapy. In addition, this study utilizes an intervention approach to investigate the biological and behavioral mechanisms underlying exercise participation in these cancer patients. Results will guide and inform large randomized controlled trials to test the effect of home-based exercise on treatment outcomes and comorbid disease risk in minority patients with cancer undergoing chemotherapy.Clinical trial registrationhttps://classic.clinicaltrials.gov/ct2/show/NCT05327452, identifier (NCT#05327452).

Published
2024
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