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2. Improving Rehabilitation Research to Optimize Care and Outcomes for People with Chronic Primary Low Back Pain: Methodological and Reporting Recommendations from a WHO Systematic Review Series

Author

Cancelliere, Carol, Yu, Hainan, Southerst, Danielle, Connell, Gaelan, Verville, Leslie, Bussières, André, Gross, Douglas P., Pereira, Paulo, Mior, Silvano, Tricco, Andrea C., Cedraschi, Christine, Brunton, Ginny, Nordin, Margareta, Shearer, Heather M., Wong, Jessica J., Hayden, Jill A., Ogilvie, Rachel, Wang, Dan, Côté, Pierre, and Hincapié, Cesar A.

Published
2023
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3. Systematic Review Procedures for the World Health Organization (WHO) Evidence Syntheses on Benefits and Harms of Structured and Standardized Education/Advice, Structured Exercise Programs, Transcutaneous Electrical Nerve Stimulation (TENS), and Needling Therapies for the Management of Chronic Low Back Pain in Adults

Author

Cancelliere, Carol, Verville, Leslie, Southerst, Danielle, Yu, Hainan, Hayden, Jill A., Ogilvie, Rachel, Bussières, André, Gross, Douglas P., Pereira, Paulo, Mior, Silvano, Tricco, Andrea C., Cedraschi, Christine, Brunton, Ginny, Nordin, Margareta, Wong, Jessica J., Shearer, Heather M., Connell, Gaelan, and Hincapié, Cesar A.

Published
2023
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4. Systematic Review to Inform a World Health Organization (WHO) Clinical Practice Guideline: Benefits and Harms of Structured Exercise Programs for Chronic Primary Low Back Pain in Adults

Author

Verville, Leslie, Ogilvie, Rachel, Hincapié, Cesar A., Southerst, Danielle, Yu, Hainan, Bussières, André, Gross, Douglas P., Pereira, Paulo, Mior, Silvano, Tricco, Andrea C., Cedraschi, Christine, Brunton, Ginny, Nordin, Margareta, Connell, Gaelan, Wong, Jessica J., Shearer, Heather M., Lee, Joyce G. B., Wang, Dan, Hayden, Jill A., and Cancelliere, Carol

Published
2023
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5. Are Exercise Interventions in Clinical Trials for Chronic Low Back Pain Dosed Appropriately to Meet the World Health Organization's Physical Activity Guidelines?

Author

Gibbs, Mitchell T., Hayden, Jill A., Cashin, Aidan G., Shah, Brishna, Gilanyi, Yannick L., Natoli, Andrew, Holmes, Grant, Ogilvie, Rachel, Hagstrom, Amanda D., McAuley, James H., Marshall, Paul W., and Jones, Matthew D.

Subjects
World Health Organization -- Laws, regulations and rules, Government regulation, Exercise therapy -- Testing -- Evaluation -- Laws, regulations and rules, Clinical trials -- Evaluation, Low back pain -- Care and treatment
Abstract

Objective. This study aimed to estimate the proportion of exercise interventions tested in clinical trials of people with chronic low back pain (CLBP) that meet the World Health Organization's (WHO) physical activity guidelines. Methods. A secondary analysis of the 2021 Cochrane review of exercise therapy for CLBP was performed. Data from each study were extracted by 1 reviewer and were checked by a second reviewer. Data extracted related to the frequency, duration and intensity of each exercise intervention, and the proportion of exercise interventions that met the WHO's physical activity guidelines (aerobic, muscle strengthening, or both) were determined. Results. The 249 included trials comprised 426 exercise interventions. Few interventions reported an exercise type and dose consistent with the WHO guidelines (aerobic: 1.6%, muscle strengthening: 5.6%, both: 1.6%). Poor reporting of exercise intensity limited our ability to determine whether interventions met the guidelines. Conclusion. Few interventions tested in clinical trials for people with CLBP prescribe an exercise type and dose consistent with the WHO guidelines. Therefore, they do not appear sufficiently dosed to achieve broader health outcomes. Future trials should investigate the effect of WHO guideline-recommended exercise interventions on patient-reported outcomes (pain and disability) as well as health-related outcomes in people with CLBP Impact. This exploratory analysis showed the lack of exercise interventions in the CLBP literature that meet the WHO's physical activity guidelines. With people in chronic pain groups, such as people with CLBP, being at higher risk for noncommunicable disease, it appears this is a key consideration for exercise practitioners when designing interventions for people with CLBP. Keywords: Aerobic, Exercise, Chronic Low Back Pain, Exercise, Physical Activity, Strengthening Exercise, Introduction Exercise is an effective guideline-based treatment for chronic low back pain (CLBP), (1) achieving similar effects on pain and disability compared to other conservative interventions. (2-4) A common justification [...]

Published
2024
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7. A survey of experts to identify methods to detect problematic studies: stage 1 of the INveStigating ProblEmatic Clinical Trials in Systematic Reviews project

Author

Wilkinson, Jack, Heal, Calvin, Antoniou, George A., Flemyng, Ella, Avenell, Alison, Barbour, Virginia, Bordewijk, Esmee M., Brown, Nicholas J.L., Clarke, Mike, Dumville, Jo, Grohmann, Steph, Gurrin, Lyle C., Hayden, Jill A., Hunter, Kylie E., Lam, Emily, Lasserson, Toby, Li, Tianjing, Lensen, Sarah, Liu, Jianping, Lundh, Andreas, Meyerowitz-Katz, Gideon, Mol, Ben W., O'Connell, Neil E., Parker, Lisa, Redman, Barbara, Seidler, Anna Lene, Sheldrick, Kyle, Sydenham, Emma, Dahly, Darren L., van Wely, Madelon, Bero, Lisa, and Kirkham, Jamie J.

Published
2024
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8. Bias in the measurement of the outcome is associated with effect sizes in randomized clinical trials on exercise therapy for chronic low back pain: a meta-epidemiological study

Author

Innocenti, Tiziano, Hayden, Jill A., Salvioli, Stefano, Giagio, Silvia, Piano, Leonardo, Cosentino, Carola, Brindisino, Fabrizio, Feller, Daniel, Ogilvie, Rachel, Gianola, Silvia, Castellini, Greta, Bargeri, Silvia, Twisk, Jos W.R., Ostelo, Raymond W., and Chiarotto, Alessandro

Published
2023
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9. Exercise treatment effect modifiers in persistent low back pain: an individual participant data meta-analysis of 3514 participants from 27 randomised controlled trials.

Author

Hayden, Jill A, Wilson, Maria N, Stewart, Samuel, Cartwright, Jennifer L, Smith, Andrea O, Riley, Richard D, van Tulder, Maurits, Bendix, Tom, Cecchi, Francesca, Costa, Leonardo OP, Dufour, Ninna, Ferreira, Manuela L, Foster, Nadine E, Gudavalli, Maruti R, Hartvigsen, Jan, Helmhout, Pieter, Kool, Jan, Koumantakis, George A, Kovacs, Francisco M, Kuukkanen, Tiina, Long, Audrey, Macedo, Luciana G, Machado, Luciana AC, Maher, Chris G, Mehling, Wolf, Morone, Giovanni, Peterson, Tom, Rasmussen-Barr, Eva, Ryan, Cormac G, Sjögren, Tuulikki, Smeets, Rob, Staal, J Bart, Unsgaard-Tøndel, Monica, Wajswelner, Henry, Yeung, Ella W, and Chronic Low Back Pain IPD Meta-Analysis Group

Subjects
Chronic Low Back Pain IPD Meta-Analysis Group, Humans, Low Back Pain, Body Mass Index, Exercise Therapy, Randomized Controlled Trials as Topic, exercise rehabilitation, intervention effectiveness, lower back, meta-analysis, Engineering, Medical and Health Sciences, Education, Sport Sciences
Abstract

BACKGROUND:Low back pain is one of the leading causes of disability worldwide. Exercise therapy is widely recommended to treat persistent non-specific low back pain. While evidence suggests exercise is, on average, moderately effective, there remains uncertainty about which individuals might benefit the most from exercise. METHODS:In parallel with a Cochrane review update, we requested individual participant data (IPD) from high-quality randomised clinical trials of adults with our two primary outcomes of interest, pain and functional limitations, and calculated global recovery. We compiled a master data set including baseline participant characteristics, exercise and comparison characteristics, and outcomes at short-term, moderate-term and long-term follow-up. We conducted descriptive analyses and one-stage IPD meta-analysis using multilevel mixed-effects regression of the overall treatment effect and prespecified potential treatment effect modifiers. RESULTS:We received IPD for 27 trials (3514 participants). For studies included in this analysis, compared with no treatment/usual care, exercise therapy on average reduced pain (mean effect/100 (95% CI) -10.7 (-14.1 to -7.4)), a result compatible with a clinically important 20% smallest worthwhile effect. Exercise therapy reduced functional limitations with a clinically important 23% improvement (mean effect/100 (95% CI) -10.2 (-13.2 to -7.3)) at short-term follow-up. Not having heavy physical demands at work and medication use for low back pain were potential treatment effect modifiers-these were associated with superior exercise outcomes relative to non-exercise comparisons. Lower body mass index was also associated with better outcomes in exercise compared with no treatment/usual care. This study was limited by inconsistent availability and measurement of participant characteristics. CONCLUSIONS:This study provides potentially useful information to help treat patients and design future studies of exercise interventions that are better matched to specific subgroups. PROTOCOL PUBLICATION: https://doi.org/10.1186/2046-4053-1-64.

Published
2020

14. Protocol for the development of a tool (INSPECT-SR) to identify problematic randomised controlled trials in systematic reviews of health interventions

Author

Wilkinson, Jack, primary, Heal, Calvin, additional, Antoniou, George A, additional, Flemyng, Ella, additional, Alfirevic, Zarko, additional, Avenell, Alison, additional, Barbour, Ginny, additional, Brown, Nicholas J L, additional, Carlisle, John, additional, Clarke, Mike, additional, Dicker, Patrick, additional, Dumville, Jo C, additional, Grey, Andrew, additional, Grohmann, Steph, additional, Gurrin, Lyle, additional, Hayden, Jill Alison, additional, Heathers, James, additional, Hunter, Kylie Elizabeth, additional, Lasserson, Toby, additional, Lam, Emily, additional, Lensen, Sarah, additional, Li, Tianjing, additional, Li, Wentao, additional, Loder, Elizabeth, additional, Lundh, Andreas, additional, Meyerowitz-Katz, Gideon, additional, Mol, Ben W, additional, O'Connell, Neil E, additional, Parker, Lisa, additional, Redman, Barbara K, additional, Seidler, Lene, additional, Sheldrick, Kyle A, additional, Sydenham, Emma, additional, Torgerson, David, additional, van Wely, Madelon, additional, Wang, Rui, additional, Bero, Lisa, additional, and Kirkham, Jamie J, additional

Published
2024
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16. The effect of spinal manipulative therapy on pain relief and function in patients with chronic low back pain: an individual participant data meta-analysis

Author

Bronfort, G., Foster, N.E., Maher, C.G., Hartvigsen, J., Balthazard, P., Cecchi, F., Ferreira, M.L., Gudavalli, M.R., Haas, M., Hidalgo, B., Hondras, M.A., Hsieh, C.Y., Learman, K., McCarthy, P.W., Petersen, T., Rasmussen-Barr, E., Skillgate, E., Verma, Y., Vismara, L., Walker, B.F., Xia, T., Zaproudina, N., de Zoete, Annemarie, Rubinstein, Sidney M., de Boer, Michiel R., Ostelo, Raymond, Underwood, Martin, Hayden, Jill A., Buffart, Laurien M., and van Tulder, Maurits W.

Published
2021
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18. Protocol for the development of a tool (INSPECT-SR) to identify problematic randomised controlled trials in systematic reviews of health interventions

Author

Wilkinson, Jack, Heal, Calvin, Antoniou, George A, Flemyng, Ella, Alfirevic, Zarko, Avenell, Alison, Barbour, Ginny, Brown, Nicholas, Carlisle, John, Clarke, Mike, Dicker, Patrick, Dumville, Jo C, Grey, Andrew, Grohmann, Steph, Gurrin, Lyle, Hayden, Jill Alison, Heathers, James, Hunter, Kylie Elizabeth, Lasserson, Toby, Lam, Emily, Lensen, Sarah, Li, Tianjing, Li, Wentao, Loder, Elizabeth, Lundh, Andreas, Meyerowitz-Katz, Gideon, Mol, Ben W, O'Connell, Neil E, Parker, Lisa, Redman, Barbara K, Seidler, Lene, Sheldrick, Kyle A, Sydenham, Emma, Torgerson, David, van Wely, Madelon, Wang, Rui, Bero, Lisa, Kirkham, Jamie J, Wilkinson, Jack, Heal, Calvin, Antoniou, George A, Flemyng, Ella, Alfirevic, Zarko, Avenell, Alison, Barbour, Ginny, Brown, Nicholas, Carlisle, John, Clarke, Mike, Dicker, Patrick, Dumville, Jo C, Grey, Andrew, Grohmann, Steph, Gurrin, Lyle, Hayden, Jill Alison, Heathers, James, Hunter, Kylie Elizabeth, Lasserson, Toby, Lam, Emily, Lensen, Sarah, Li, Tianjing, Li, Wentao, Loder, Elizabeth, Lundh, Andreas, Meyerowitz-Katz, Gideon, Mol, Ben W, O'Connell, Neil E, Parker, Lisa, Redman, Barbara K, Seidler, Lene, Sheldrick, Kyle A, Sydenham, Emma, Torgerson, David, van Wely, Madelon, Wang, Rui, Bero, Lisa, and Kirkham, Jamie J

Abstract

Introduction Randomised controlled trials (RCTs) inform healthcare decisions. It is now apparent that some published RCTs contain false data and some appear to have been entirely fabricated. Systematic reviews are performed to identify and synthesise all RCTs that have been conducted on a given topic. While it is usual to assess methodological features of the RCTs in the process of undertaking a systematic review, it is not usual to consider whether the RCTs contain false data. Studies containing false data therefore go unnoticed and contribute to systematic review conclusions. The INveStigating ProblEmatic Clinical Trials in Systematic Reviews (INSPECT-SR) project will develop a tool to assess the trustworthiness of RCTs in systematic reviews of healthcare-related interventions. Methods and analysis The INSPECT-SR tool will be developed using expert consensus in combination with empirical evidence, over five stages: (1) a survey of experts to assemble a comprehensive list of checks for detecting problematic RCTs, (2) an evaluation of the feasibility and impact of applying the checks to systematic reviews, (3) a Delphi survey to determine which of the checks are supported by expert consensus, culminating in, (4) a consensus meeting to select checks to be included in a draft tool and to determine its format and (5) prospective testing of the draft tool in the production of new health systematic reviews, to allow refinement based on user feedback. We anticipate that the INSPECT-SR tool will help researchers to identify problematic studies and will help patients by protecting them from the influence of false data on their healthcare. Ethics and dissemination The University of Manchester ethics decision tool was used, and this returned the result that ethical approval was not required for this project (30 September 2022), which incorporates secondary research and surveys of professionals about subjects relating to their expertise. Informed consent will be obtained from

Published
2024
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19. Implementation of back to living well, a community-based program for the tertiary prevention of low back pain: a study protocol.

Author

Macedo, Luciana, Di Pelino, Stephanie, Santos, Veronica Souza, Richardson, Julie, MacDermid, Joy, Hancock, Mark, Battie, Michele C., Saragiotto, Bruno T., Hayden, Jill A., Rushton, Alison, Packham, Tara, Freman, Matt, Bray, Steven, Griffin, Meridith, Hladysh, Genevieve, Miller, Pat, and Attwell, Suzan

Subjects
LUMBAR pain, COMMUNITY-based programs, INSTITUTIONAL review boards, RESEARCH protocols, PATIENT preferences, PAIN
Abstract

Background: The current literature supports the effectiveness of exercise, education, and self-management interventions for the long-term management of persistent low back pain. However, there is significant uncertainty about the implementation of interventions related to barriers, facilitators, and patient's preferences. This study will evaluate the Back to Living Well program implementation from a participant and organizational perspective. More specifically we address the following objectives: 1) identify program barriers and facilitators from participants' perspectives, 2) identify factors related to program, personal and contextual factors that contribute to negative and positive outcomes, and outcome trajectories, 3) identify factors influencing participants' selection of an in-person or e-health program, and 4) evaluate program specific barriers and facilitators from the organization and care delivery perspectives. Methods: This study will utilize a mixed-method convergent design including a longitudinal cohort strand and a longitudinal qualitative interview strand. The RE-AIM framework will be used to assess program implementation. Participants (n = 90, 1:1: in person or virtual) who choose to register in the program as well as staff (n = 10 to 15) involved in the delivery of the program will be invited to participate. Participants will participate in a 12-week physical activity, education, and self-management program. Implementation outcomes will be measured at 3-, 6-, 12-months, and six months after the end of the follow-ups. Interview scripts and directed content analysis will be constructed based on the Theoretical Domains Framework and the Neuromatrix Model of Pain, Theoretical Domains Framework. Staff interviews will be constructed and analyzed using the Consolidated Framework for Implementation Research. Participants will also complete pain, disability, quality of life and psychological questionnaires, wear an activity tracker at all time points, and complete weekly pain and activity limitation questions using a mobile application. Discussion: The study results will provide evidence to inform potential future implementation of the program. An effective, appropriately targeted, and well implemented exercise program for the long-term management (i.e., tertiary prevention) of LBP could minimize the burden of the condition on patients, the health care system and society. Trial registration: ClinicalTrials.gov NCT05929846. This (Registration Date: July 3 2023) study has been approved by the Hamilton Integrated Research Ethics Board Project ID#15,354. [ABSTRACT FROM AUTHOR]

Published
2024
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20. An online training resource for clinicians to optimise exercise prescription for persistent low back pain: Design, development and usability testing.

Author

Wood, Lianne, Dean, Sarah, Booth, Vicky, Hayden, Jill A., and Foster, Nadine E.

Subjects
CURRICULUM evaluation, SOCIAL media, SCALE analysis (Psychology), MEDICAL personnel, THERAPEUTICS, HUMAN services programs, RESEARCH funding, EXERCISE therapy, INTERVIEWING, EVALUATION of human services programs, DESCRIPTIVE statistics, CONFIDENCE, QUANTITATIVE research, ONLINE education, RESEARCH methodology, PHYSICIAN practice patterns, EXPERTISE, DRUG prescribing, HEALTH outcome assessment, LUMBAR pain
Abstract

Background: Low back pain (LBP) is the leading cause of disability worldwide. A recent realist review identified the behavioural mechanisms of trust, motivation, and confidence as key to optimising exercise prescription for persistent LBP. Objectives: Our objectives were to (1) design and develop an online training programme, and (2) gain end‐user feedback on the useability, usefulness, informativeness and confidence in using the online training programme using a mixed‐methods, pre‐post study design. Participants and Intervention: The online training programme was designed and developed using the results from a realist review, and input from a multi‐disciplinary stakeholder group. A five‐module online training programme was piloted by the first 10 respondents who provided feedback on the course. Further modifications were made prior to additional piloting. The satisfaction, usefulness, ease of use, and confidence of clinicians in applying the learned principles were assessed on completion. Results: The online programme was advertised to clinicians using social media. Forty‐four respondents expressed initial interest, of which 22 enrolled and 18 completed the course. Of the participants, most were physiotherapists (n = 16/18, 88.9%), aged between 30 and 49 (n = 11/18, 61.1%). All participants were satisfied with the course content, rated the course platform as easy to use and useful, and reported that they were very confident to apply the learning. Most (n = 10/14, 71.4%) reported that their manner of prescribing exercise had changed after completion of the course. Conclusions: An online training programme to optimise exercise prescription for persistent LBP appears to be easy to use, informative and improves confidence to apply the learning. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Protocol for the development of a tool (INSPECT-SR) to identify problematic randomised controlled trials in systematic reviews of health interventions

Author

Wilkinson, Jack, primary, Heal, Calvin, additional, Antoniou, George A., additional, Flemyng, Ella, additional, Alfirevic, Zarko, additional, Avenell, Alison, additional, Barbour, Virginia, additional, Brown, Nicholas J L, additional, Carlisle, John, additional, Clarke, Mike, additional, Dicker, Patrick, additional, Dumville, Jo, additional, Grey, Andrew, additional, Grohmann, Steph, additional, Gurrin, Lyle C, additional, Hayden, Jill A, additional, Heathers, James, additional, Hunter, Kylie E, additional, Lasserson, Toby, additional, Lam, Emily, additional, Lensen, Sarah, additional, Li, Tianjing, additional, Li, Wentao, additional, Loder, Elizabeth, additional, Lundh, Andreas, additional, Meyerowitz-Katz, Gideon, additional, Mol, Ben W, additional, O’Connell, Neil E, additional, Parker, Lisa, additional, Redman, Barbara K., additional, Seidler, Anna Lene, additional, Sheldrick, Kyle A, additional, Sydenham, Emma, additional, Torgerson, David J, additional, van Wely, Madelon, additional, Wang, Rui, additional, Bero, Lisa, additional, and Kirkham, Jamie J, additional

Published
2023
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27. Are Exercise Interventions in Clinical Trials for Chronic Low Back Pain Dosed Appropriately to Meet the World Health Organization’s Physical Activity Guidelines?

Author

Gibbs, Mitchell T, primary, Hayden, Jill A, additional, Cashin, Aidan G, additional, Shah, Brishna, additional, Gilanyi, Yannick L, additional, Natoli, Andrew, additional, Holmes, Grant, additional, Ogilvie, Rachel, additional, Hagstrom, Amanda D, additional, McAuley, James H, additional, Marshall, Paul W, additional, and Jones, Matthew D, additional

Published
2023
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31. Living systematic reviews: 4. Living guideline recommendations

Author

Agoritsas, Thomas, Hilton, John, Perron, Caroline, Akl, Elie, Hodder, Rebecca, Pestridge, Charlotte, Albrecht, Lauren, Horsley, Tanya, Platt, Joanne, Armstrong, Rebecca, Nguyen, Phi Hung, Plovnick, Robert, Arno, Anneliese, Ivers, Noah, Quinn, Gail, Au, Agnes, Johnston, Renea, Rada, Gabriel, Bagg, Matthew, Jones, Arwel, Ravaud, Philippe, Boden, Catherine, Kahale, Lara, Richter, Bernt, Boisvert, Isabelle, Keshavarz, Homa, Ryan, Rebecca, Brandt, Linn, Kolakowsky-Hayner, Stephanie A., Salama, Dina, Brazinova, Alexandra, Nagraj, Sumanth Kumbargere, Salanti, Georgia, Buchbinder, Rachelle, Lasserson, Toby, Santaguida, Lina, Champion, Chris, Lawrence, Rebecca, Santesso, Nancy, Chandler, Jackie, Les, Zbigniew, Schünemann, Holger J., Charidimou, Andreas, Leucht, Stefan, Shemilt, Ian, Chou, Roger, Low, Nicola, Sherifali, Diana, Churchill, Rachel, Maas, Andrew, Siemieniuk, Reed, Cnossen, Maryse C., MacLehose, Harriet, Simmonds, Mark, Cossi, Marie-Joelle, Macleod, Malcolm, Skoetz, Nicole, Counotte, Michel, Marshall, Iain, Soares-Weiser, Karla, Craigie, Samantha, Marshall, Rachel, Srikanth, Velandai, Dahm, Philipp, Martin, Nicole, Sullivan, Katrina, Danilkewich, Alanna, Martínez García, Laura, Synnot, Anneliese, Danko, Kristen, Mavergames, Chris, Taylor, Mark, Donoghue, Emma, Maxwell, Lara J., Thayer, Kris, Dressler, Corinna, McAuley, James, Thomas, James, Egan, Cathy, McDonald, Steve, Tritton, Roger, Elliott, Julian, McKenzie, Joanne, Tsafnat, Guy, Elliott, Sarah A., Meerpohl, Joerg, Tugwell, Peter, Etxeandia, Itziar, Merner, Bronwen, Turgeon, Alexis, Featherstone, Robin, Mondello, Stefania, Turner, Tari, Foxlee, Ruth, Morley, Richard, van Valkenhoef, Gert, Garner, Paul, Munafo, Marcus, Vandvik, Per, Gerrity, Martha, Munn, Zachary, Wallace, Byron, Glasziou, Paul, Murano, Melissa, Wallace, Sheila A., Green, Sally, Newman, Kristine, Watts, Chris, Grimshaw, Jeremy, Nieuwlaat, Robby, Weeks, Laura, Gurusamy, Kurinchi, Nikolakopoulou, Adriani, Weigl, Aaron, Haddaway, Neal, Noel-Storr, Anna, Wells, George, Hartling, Lisa, O'Connor, Annette, Wiercioch, Wojtek, Hayden, Jill, Page, Matthew, Wolfenden, Luke, Helfand, Mark, Pahwa, Manisha, Yepes Nuñez, Juan José, Higgins, Julian, Pardo, Jordi Pardo, Yost, Jennifer, Hill, Sophie, Pearson, Leslea, Akl, Elie A., Meerpohl, Joerg J., and Kahale, Lara A.

Published
2017
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32. Living systematic reviews: 3. Statistical methods for updating meta-analyses

Author

Agoritsas, Thomas, Hilton, John, Perron, Caroline, Akl, Elie, Hodder, Rebecca, Pestridge, Charlotte, Albrecht, Lauren, Horsley, Tanya, Platt, Joanne, Armstrong, Rebecca, Nguyen, Phi Hung, Plovnick, Robert, Arno, Anneliese, Ivers, Noah, Quinn, Gail, Au, Agnes, Johnston, Renea, Rada, Gabriel, Bagg, Matthew, Jones, Arwel, Ravaud, Philippe, Boden, Catherine, Kahale, Lara, Richter, Bernt, Boisvert, Isabelle, Keshavarz, Homa, Ryan, Rebecca, Brandt, Linn, Kolakowsky-Hayner, Stephanie A., Salama, Dina, Brazinova, Alexandra, Nagraj, Sumanth Kumbargere, Salanti, Georgia, Buchbinder, Rachelle, Lasserson, Toby, Santaguida, Lina, Champion, Chris, Lawrence, Rebecca, Santesso, Nancy, Chandler, Jackie, Les, Zbigniew, Schünemann, Holger J., Charidimou, Andreas, Leucht, Stefan, Shemilt, Ian, Chou, Roger, Low, Nicola, Sherifali, Diana, Churchill, Rachel, Maas, Andrew, Siemieniuk, Reed, Cnossen, Maryse C., MacLehose, Harriet, Simmonds, Mark, Cossi, Marie-Joelle, Macleod, Malcolm, Skoetz, Nicole, Counotte, Michel, Marshall, Iain, Soares-Weiser, Karla, Craigie, Samantha, Marshall, Rachel, Srikanth, Velandai, Dahm, Philipp, Martin, Nicole, Sullivan, Katrina, Danilkewich, Alanna, Martínez García, Laura, Synnot, Anneliese, Danko, Kristen, Mavergames, Chris, Taylor, Mark, Donoghue, Emma, Maxwell, Lara J., Thayer, Kris, Dressler, Corinna, McAuley, James, Thomas, James, Egan, Cathy, McDonald, Steve, Tritton, Roger, Elliott, Julian, McKenzie, Joanne, Tsafnat, Guy, Elliott, Sarah A., Meerpohl, Joerg, Tugwell, Peter, Etxeandia, Itziar, Merner, Bronwen, Turgeon, Alexis, Featherstone, Robin, Mondello, Stefania, Turner, Tari, Foxlee, Ruth, Morley, Richard, van Valkenhoef, Gert, Garner, Paul, Munafo, Marcus, Vandvik, Per, Gerrity, Martha, Munn, Zachary, Wallace, Byron, Glasziou, Paul, Murano, Melissa, Wallace, Sheila A., Green, Sally, Newman, Kristine, Watts, Chris, Grimshaw, Jeremy, Nieuwlaat, Robby, Weeks, Laura, Gurusamy, Kurinchi, Nikolakopoulou, Adriani, Weigl, Aaron, Haddaway, Neal, Noel-Storr, Anna, Wells, George, Hartling, Lisa, O'Connor, Annette, Wiercioch, Wojtek, Hayden, Jill, Page, Matthew, Wolfenden, Luke, Helfand, Mark, Pahwa, Manisha, Yepes Nuñez, Juan José, Higgins, Julian, Pardo, Jordi Pardo, Yost, Jennifer, Hill, Sophie, and Pearson, Leslea

Published
2017
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33. Living systematic review: 1. Introduction—the why, what, when, and how

Author

Agoritsas, Thomas, Hilton, John, Perron, Caroline, Akl, Elie, Hodder, Rebecca, Pestridge, Charlotte, Albrecht, Lauren, Horsley, Tanya, Platt, Joanne, Armstrong, Rebecca, Nguyen, Phi Hung, Plovnick, Robert, Arno, Anneliese, Ivers, Noah, Quinn, Gail, Au, Agnes, Johnston, Renea, Rada, Gabriel, Bagg, Matthew, Jones, Arwel, Ravaud, Philippe, Boden, Catherine, Kahale, Lara, Richter, Bernt, Boisvert, Isabelle, Keshavarz, Homa, Ryan, Rebecca, Brandt, Linn, Kolakowsky-Hayner, Stephanie A., Salama, Dina, Brazinova, Alexandra, Nagraj, Sumanth Kumbargere, Salanti, Georgia, Buchbinder, Rachelle, Lasserson, Toby, Santaguida, Lina, Champion, Chris, Lawrence, Rebecca, Santesso, Nancy, Chandler, Jackie, Les, Zbigniew, Schünemann, Holger J., Charidimou, Andreas, Leucht, Stefan, Shemilt, Ian, Chou, Roger, Low, Nicola, Sherifali, Diana, Churchill, Rachel, Maas, Andrew, Siemieniuk, Reed, Cnossen, Maryse C., MacLehose, Harriet, Simmonds, Mark, Cossi, Marie-Joelle, Macleod, Malcolm, Skoetz, Nicole, Counotte, Michel, Marshall, Iain, Soares-Weiser, Karla, Craigie, Samantha, Marshall, Rachel, Srikanth, Velandai, Dahm, Philipp, Martin, Nicole, Sullivan, Katrina, Danilkewich, Alanna, Martínez García, Laura, Synnot, Anneliese, Danko, Kristen, Mavergames, Chris, Taylor, Mark, Donoghue, Emma, Maxwell, Lara J., Thayer, Kris, Dressler, Corinna, McAuley, James, Thomas, James, Egan, Cathy, McDonald, Steve, Tritton, Roger, Elliott, Julian, McKenzie, Joanne, Tsafnat, Guy, Elliott, Sarah A., Meerpohl, Joerg, Tugwell, Peter, Etxeandia, Itziar, Merner, Bronwen, Turgeon, Alexis, Featherstone, Robin, Mondello, Stefania, Turner, Tari, Foxlee, Ruth, Morley, Richard, van Valkenhoef, Gert, Garner, Paul, Munafo, Marcus, Vandvik, Per, Gerrity, Martha, Munn, Zachary, Wallace, Byron, Glasziou, Paul, Murano, Melissa, Wallace, Sheila A., Green, Sally, Newman, Kristine, Watts, Chris, Grimshaw, Jeremy, Nieuwlaat, Robby, Weeks, Laura, Gurusamy, Kurinchi, Nikolakopoulou, Adriani, Weigl, Aaron, Haddaway, Neal, Noel-Storr, Anna, Wells, George, Hartling, Lisa, O'Connor, Annette, Wiercioch, Wojtek, Hayden, Jill, Page, Matthew, Wolfenden, Luke, Helfand, Mark, Pahwa, Manisha, Yepes Nuñez, Juan José, Higgins, Julian, Pardo, Jordi Pardo, Yost, Jennifer, Hill, Sophie, Pearson, Leslea, Elliott, Julian H., Akl, Elie A., and Tovey, David

Published
2017
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34. Living systematic reviews: 2. Combining human and machine effort

Author

Agoritsas, Thomas, Hilton, John, Perron, Caroline, Akl, Elie, Hodder, Rebecca, Pestridge, Charlotte, Albrecht, Lauren, Horsley, Tanya, Platt, Joanne, Armstrong, Rebecca, Nguyen, Phi Hung, Plovnick, Robert, Arno, Anneliese, Ivers, Noah, Quinn, Gail, Au, Agnes, Johnston, Renea, Rada, Gabriel, Bagg, Matthew, Jones, Arwel, Ravaud, Philippe, Boden, Catherine, Kahale, Lara, Richter, Bernt, Boisvert, Isabelle, Keshavarz, Homa, Ryan, Rebecca, Brandt, Linn, Kolakowsky-Hayner, Stephanie A., Salama, Dina, Brazinova, Alexandra, Nagraj, Sumanth Kumbargere, Salanti, Georgia, Buchbinder, Rachelle, Lasserson, Toby, Santaguida, Lina, Champion, Chris, Lawrence, Rebecca, Santesso, Nancy, Chandler, Jackie, Les, Zbigniew, Schünemann, Holger J., Charidimou, Andreas, Leucht, Stefan, Shemilt, Ian, Chou, Roger, Low, Nicola, Sherifali, Diana, Churchill, Rachel, Maas, Andrew, Siemieniuk, Reed, Cnossen, Maryse C., MacLehose, Harriet, Simmonds, Mark, Cossi, Marie-Joelle, Macleod, Malcolm, Skoetz, Nicole, Counotte, Michel, Marshall, Iain, Soares-Weiser, Karla, Craigie, Samantha, Marshall, Rachel, Srikanth, Velandai, Dahm, Philipp, Martin, Nicole, Sullivan, Katrina, Danilkewich, Alanna, Martínez García, Laura, Synnot, Anneliese, Danko, Kristen, Mavergames, Chris, Taylor, Mark, Donoghue, Emma, Maxwell, Lara J., Thayer, Kris, Dressler, Corinna, McAuley, James, Thomas, James, Egan, Cathy, McDonald, Steve, Tritton, Roger, Elliott, Julian, McKenzie, Joanne, Tsafnat, Guy, Elliott, Sarah A., Meerpohl, Joerg, Tugwell, Peter, Etxeandia, Itziar, Merner, Bronwen, Turgeon, Alexis, Featherstone, Robin, Mondello, Stefania, Turner, Tari, Foxlee, Ruth, Morley, Richard, van Valkenhoef, Gert, Garner, Paul, Munafo, Marcus, Vandvik, Per, Gerrity, Martha, Munn, Zachary, Wallace, Byron, Glasziou, Paul, Murano, Melissa, Wallace, Sheila A., Green, Sally, Newman, Kristine, Watts, Chris, Grimshaw, Jeremy, Nieuwlaat, Robby, Weeks, Laura, Gurusamy, Kurinchi, Nikolakopoulou, Adriani, Weigl, Aaron, Haddaway, Neal, Noel-Storr, Anna, Wells, George, Hartling, Lisa, O'Connor, Annette, Wiercioch, Wojtek, Hayden, Jill, Page, Matthew, Wolfenden, Luke, Helfand, Mark, Pahwa, Manisha, Yepes Nuñez, Juan José, Higgins, Julian, Pardo, Jordi Pardo, Yost, Jennifer, Hill, Sophie, Pearson, Leslea, and McDonald, Steven

Published
2017
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35. Exercise treatments for chronic low back pain: a network meta-analysis

Author

Hayden, Jill A, additional, Ogilvie, Rachel, additional, Kashif, Shazia, additional, Singh, Sareen, additional, Boulos, Leah, additional, Stewart, Samuel A, additional, Wieland, L Susan, additional, Jesus-Moraleida, Fabianna R, additional, Saragiotto, Bruno T, additional, Yamato, Tiê P, additional, de Zoete, Annemarie, additional, Bülow, Kasper, additional, Almeida de Oliveira, Lisandra, additional, Bejarano, Geronimo, additional, and Cancelliere, Carolina, additional

Published
2023
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38. Prognostic factor research

Author

Riley, Richard D, additional, Moons, Karel GM, additional, Hayden, Jill A, additional, Sauerbrei, Willi, additional, and Altman, Douglas G, additional

Published
2019
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39. Commentary: collaborative systematic review may produce and share high-quality, comparative evidence more efficiently

Author

Hayden, Jill A, primary, Hayden, Jill A., additional, Ogilvie, Rachel, additional, Singh, Sareen, additional, Kashif, Shazia, additional, Hartvigsen, Jan, additional, Maher, Chris G., additional, Furlan, Andrea D., additional, Lasserson, Toby, additional, Tugwell, Peter, additional, van Tulder, Maurits, additional, Qaseem, Amir, additional, Ferreira, Manuela L., additional, Buchbinder, Rachelle, additional, Wieland, L. Susan, additional, de Jesus-Moraleida, Fabianna Resende, additional, Saragiotto, Bruno T., additional, Yamato, Tie Parma, additional, de Zoete, Annemarie, additional, Bülow, Kasper, additional, de Oliveira, Lisandra Almeida, additional, Bejarano, Geronimo, additional, and Cancelliere, Carol, additional

Published
2022
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40. Exercise treatments for chronic low back pain:a network meta-analysis

Author

Hayden, Jill A., Ogilvie, Rachel, Kashif, Shazia, Singh, Sareen, Boulos, Leah, Stewart, Samuel A., Wieland, L. Susan, Jesus-Moraleida, Fabianna R., Saragiotto, Bruno T., Yamato, Tiê P., de Zoete, Annemarie, Bülow, Kasper, Almeida de Oliveira, Lisandra, Bejarano, Geronimo, and Cancelliere, Carolina

Abstract

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. The objectives of this systematic review, conducted using a collaborative review model, are to:. Assess the effectiveness of exercise treatment (overall) in adults with chronic non-specific low back pain on important individual health outcomes: pain, functional limitations, health-related quality of life, depression, and adverse effects versus comparison treatments: (a) placebo, sham, or attention control, (b) no trial treatment (including waiting lists, control groups described as having no treatment provided, usual/normal care not controlled by the trial available to all treatment groups, or when the exercise and comparison groups receive the same co-interventions, allowing the effect of exercise treatment to be isolated), and (c) other conservative treatments (eight categories). Estimate the treatment effects and associated uncertainty for comparisons of different specific types of exercise treatment in adults with chronic non-specific low back pain to each other, and to each comparison treatment, using direct and indirect evidence with network meta-analysis. Estimate the treatment effects and associated uncertainty for comparisons of treatments composed of different exercise type categories, design, delivery, dose, and additional treatment components, and their combinations, using direct and indirect evidence with component network meta-analysis.

Published
2023

42. Exercise treatments for chronic low back pain: a network meta-analysis

Author

Hayden, Jill A., Ogilvie, Rachel, Kashif, Shazia, Singh, Sareen, Boulos, Leah, Stewart, Samuel A., Wieland, L. Susan, Jesus-Moraleida, Fabianna R., Saragiotto, Bruno T., Yamato, Tiê P., de Zoete, Annemarie, Bülow, Kasper, Almeida de Oliveira, Lisandra, Bejarano, Geronimo, Cancelliere, Carolina, Hayden, Jill A., Ogilvie, Rachel, Kashif, Shazia, Singh, Sareen, Boulos, Leah, Stewart, Samuel A., Wieland, L. Susan, Jesus-Moraleida, Fabianna R., Saragiotto, Bruno T., Yamato, Tiê P., de Zoete, Annemarie, Bülow, Kasper, Almeida de Oliveira, Lisandra, Bejarano, Geronimo, and Cancelliere, Carolina

Abstract

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. The objectives of this systematic review, conducted using a collaborative review model, are to:. Assess the effectiveness of exercise treatment (overall) in adults with chronic non-specific low back pain on important individual health outcomes: pain, functional limitations, health-related quality of life, depression, and adverse effects versus comparison treatments: (a) placebo, sham, or attention control, (b) no trial treatment (including waiting lists, control groups described as having no treatment provided, usual/normal care not controlled by the trial available to all treatment groups, or when the exercise and comparison groups receive the same co-interventions, allowing the effect of exercise treatment to be isolated), and (c) other conservative treatments (eight categories). Estimate the treatment effects and associated uncertainty for comparisons of different specific types of exercise treatment in adults with chronic non-specific low back pain to each other, and to each comparison treatment, using direct and indirect evidence with network meta-analysis. Estimate the treatment effects and associated uncertainty for comparisons of treatments composed of different exercise type categories, design, delivery, dose, and additional treatment components, and their combinations, using direct and indirect evidence with component network meta-analysis.

Published
2023
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43. Pain catastrophising and kinesiophobia mediate pain and physical function improvements with Pilates exercise in chronic low back pain::a mediation analysis of a randomised controlled trial

Author

Wood, Lianne, Bejarano, Geronimo, Csiernik, Ben, Miyamoto, Gisela C, Mansell, Gemma, Hayden, Jill A, Lewis, Martyn, Cashin, Aidan G, Wood, Lianne, Bejarano, Geronimo, Csiernik, Ben, Miyamoto, Gisela C, Mansell, Gemma, Hayden, Jill A, Lewis, Martyn, and Cashin, Aidan G

Abstract

QUESTION: How much are the reductions in pain intensity and improvements in physical function from Pilates exercise mediated by changes in pain catastrophising and kinesiophobia? DESIGN: This was a secondary causal mediation analysis of a four-arm randomised controlled trial testing Pilates exercise dosage (once, twice or thrice per week) against a booklet control. PARTICIPANTS: Two hundred and fifty-five people with chronic low back pain. DATA ANALYSIS: All analyses were conducted in R software (version 4.1.2) following a preregistered analysis plan. A directed acyclic graph was constructed to identify potential pre-treatment mediator-outcome confounders. For each mediator model, we estimated the intervention-mediator effect, the mediator-outcome effect, the total natural indirect effect (TNIE), the pure natural direct effect (PNDE), and the total effect (TE). RESULTS: Pain catastrophising mediated the effect of Pilates exercise compared with control on the outcomes pain intensity (TNIE MD -0.21, 95% CI -0.47 to -0.03) and physical function (TNIE MD -0.64, 95% CI -1.20 to -0.18). Kinesiophobia mediated the effect of Pilates exercise compared with control on the outcomes pain intensity (TNIE MD -0.31, 95% CI -0.68 to -0.02) and physical function (TNIE MD -1.06, 95% CI -1.70 to -0.49). The proportion mediated by each mediator was moderate (21 to 55%). CONCLUSION: Reductions in pain catastrophising and kinesiophobia partially mediated the pathway to improved pain intensity and physical function when using Pilates exercise for chronic low back pain. These psychological components may be important treatment targets for clinicians and researchers to consider when prescribing exercise for chronic low back pain.

Published
2023

47. Association between trial registration and quality of conduct and reporting: a meta-epidemiological study

Author

Hayden, Jill Alison, Ogilvie, Rachel, Sareen Singh, Kashif, Shazia, Pinto, Rafael Z, and Silva, Samuel

Subjects
Epidemiology, Medicine and Health Sciences, Public Health
Abstract

This protocol outlines a planned meta-epidemiological study to investigate how trial registration relates to several quality of conduct and reporting characteristics, and treatment effect estimates, for trials included in a large Cochrane review update on exercise treatments for chronic low back pain.

Published
2023
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48. Contribution of small sample size trials in systematic reviews of treatment effects

Author

Feng, Cindy, Hayden, Jill Alison, Ogilvie, Rachel, Kashif, Shazia, and MacDonald, Alanna

Subjects
Epidemiology, Medicine and Health Sciences, Public Health
Abstract

This study will use data from a previously published systematic review about the effectiveness of treatment of chronic non-specific back pain to: describe sample size of published trials in this broad topic area, investigate how trial sample size is related to the trial conduct, size of effect and certainty of evidence, and calculate sample size of new trials that would be required to modify evidence for various treatment comparisons. Our explanatory variable, sample size, will be defined by the smallest arm size in the trial, and descriptive analyses will be conducted by defining a ‘small’ sample size with a threshold of 30 participants. Response variables will include trial conduct (Cochrane Risk of Bias tool); treatment effect (pain intensity and functional limitations); and certainty of evidence (GRADE [Grading of Recommendation, Assessment, Development and Evaluation] recommendations). Our statistical plan will include univariable and multivariable meta-regression analyses to assess the relationship between sample size and trial conduct characteristics, and between sample size and treatment effect, and certainty of evidence. We will also use cumulative meta-analysis to estimate the year in the history of trials published in the field where defined sample sizes stopped contributing information to improve the certainty of evidence. Last, we will use prospective conditional analyses to estimate the “next” trial size and characteristics that would be needed to modify results and interpretation for each comparison. This work will inform future trials in this field regarding what sample sizes can positively contribute to the estimate and certainty of evidence.

Published
2023
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