67 results on '"Hayato Ohtani"'
Search Results
2. Mechanism of Drug-Eluting Stent Thrombosis Diagnosed by Histopathological Evaluation of Directional Coronary Atherectomy Specimen
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Kazuki Ito, MD, Shinya Fujita, MD, Atsushi Sakamoto, MD, PhD, Hayato Ohtani, MD, PhD, Masahiro Muto, MD, and Yuichiro Maekawa, MD, PhD
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directional coronary atherectomy ,drug-eluting stent ,in-stent restenosis ,in-stent thrombosis ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
An 89-year-old man with a history of percutaneous coronary intervention using a sirolimus-eluting stent presented with recurrent in-stent occlusion. Pathological assessment of the neointima resected via directional coronary atherectomy revealed a double-layered thrombus. Clopidogrel resistance and limited antithrombotic regimen owing to high bleeding risk likely resulted in the in-stent thrombotic occlusion.
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- 2023
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3. A Case of Coronary Arteritis and Myocardial Involvement With Associated IgG4-Related Disease
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Kenichiro Suwa, MD, Noriyoshi Ogawa, MD, Nobuko Yoshizawa, MD, Mayu Fujihiro, MD, Atsushi Sakamoto, MD, Hayato Ohtani, MD, Masao Saotome, MD, and Yuichiro Maekawa, MD
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cardiac magnetic resonance ,coronary arteritis ,IgG4-related disease ,myocardial involvement ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
A 56-year-old male subject with bilateral eyelid swelling was diagnosed with an immunoglobulin G4–related disease. After whole-body surveillance, concomitant coronary arteritis with a mural thrombus and myocardial involvement were observed. In this case, multimodal diagnostic imaging assessment led to the diagnosis of both coronary arteritis and myocardial fibrosis associated with immunoglobulin G4–related disease. (Level of Difficulty: Advanced.)
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- 2023
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4. Association of Malnutrition and High Bleeding Risk with Long-Term Prognosis in Patients with Acute Coronary Syndrome following Percutaneous Coronary Intervention
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Hiromitsu Kataoka, Sayumi Suzuki, Yuichi Suzuki, Ryota Sato, Makoto Sano, Satoshi Mogi, Atsushi Sakamoto, Kenichiro Suwa, Yoshihisa Naruse, Hayato Ohtani, Masao Saotome, Mikihiro Shimizu, Keiichi Odagiri, and Yuichiro Maekawa
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acute coronary syndrome ,malnutrition ,percutaneous coronary intervention ,high bleeding risk ,Medicine - Abstract
Background: Malnutrition in cardiovascular disease is associated with poor prognosis, especially in patients with heart failure and acute coronary syndrome (ACS). High bleeding risk is also linked to coronary artery disease prognosis, including ACS. However, whether the extent of malnutrition and high bleeding risk have a cumulative impact on the long-term prognosis of patients with ACS who undergo percutaneous coronary intervention remains unclear. Methods: We analyzed 275 patients with ACS treated with percutaneous coronary intervention. The Controlling Nutritional Status score and Japanese version of the Academic Research Consortium for High Bleeding Risk criteria (J-HBR) were retrospectively evaluated. The primary and secondary outcomes were adjusted using the inverse probability treatment weighting method. Results: The prevalence of moderate or severe malnutrition in this cohort was 16%. Kaplan–Meier analysis showed a significantly higher incidence of major adverse cardiovascular and cerebrovascular events in patients who were moderately or severely malnourished than in those who were not. Notably, the incidence of these major events was similar between severely malnourished patients with J-HBR and those without. Conclusion: Moderate or severe malnutrition has a significant impact on the long-term prognosis of patients with ACS who undergo percutaneous coronary intervention.
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- 2023
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5. Individualised left anterior oblique projection for lead implantation into interventricular septum
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Makoto Sano, Yuichiro Maekawa, Yoshihisa Naruse, Yutaro Kaneko, Tomoaki Sakakibara, Taro Narumi, Satoshi Mogi, Kenichiro Suwa, Hayato Ohtani, Masao Saotome, and Tsuyoshi Urushida
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objective We sought to investigate whether it is possible to obtain individualised left anterior oblique (LAO) by preprocedural electrocardiographic parameters and, if so, whether these parameters can help to improve the success rate of right ventricular (RV) lead implantation into the interventricular septum.Methods In this observational study, we assessed the relationship between preoperative electrocardiographic parameters and the angle of the interventricular septum obtained using thoracic CT. The participants were divided into two groups: a retrospective derivation cohort to derive the optimal formula for the individual septum axis, and a prospective internal validation cohort to which we applied the optimal formula and implanted using the new method.Results In the retrospective derivation cohort (n=39), the mean angle of individualised LAO assessed by thoracic CT was 53.1°±8.9°, and the preoperative ECG QRS axis was strongly correlated with the interventricular septum axis (R2=0.490). LAO projection derived from the preoperative ECG QRS axis confirmed that the RV lead was placed in the interventricular septum during the pacemaker procedure in the prospective internal validation group (n=30). The success rate for placing the RV lead into the interventricular septum was significantly improved in the internal validation cohort (93% vs 64%, p
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- 2022
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6. Feasibility of Short-Term Aggressive Lipid-Lowering Therapy with the PCSK9 Antibody in Acute Coronary Syndrome
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Satoshi Yamashita, Atsushi Sakamoto, Satoshi Shoji, Yoshitaka Kawaguchi, Yasushi Wakabayashi, Masaki Matsunaga, Kiyohisa Suguro, Yuji Matsumoto, Hiroyuki Takase, Tomoya Onodera, Kei Tawarahara, Masahiro Muto, Yasutaka Shirasaki, Hideki Katoh, Makoto Sano, Kenichiro Suwa, Yoshihisa Naruse, Hayato Ohtani, Masao Saotome, Tsuyoshi Urushida, Shun Kohsaka, Eisaku Okada, and Yuichiro Maekawa
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PCSK9 antibody ,acute coronary syndrome ,lipid-lowering therapy ,low-density lipoprotein cholesterol ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: The guideline-recommended low-density lipoprotein cholesterol target level of p = 0.498). The two groups showed no significant differences in hospitalization for worsening heart failure and adverse events. Conclusions: In ACS patients who underwent PCI, short-term PCSK9 antibody therapy with conventional LLT was feasible in this pilot clinical trial. Long-term follow-up in a larger scale clinical trial is warranted.
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- 2023
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7. Prevalence and Characteristics of Inspiration-Induced Negative Left Atrial Pressure during Pulmonary Vein Isolation
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Takenori Ikoma, Yoshihisa Naruse, Yutaro Kaneko, Tomoaki Sakakibara, Taro Narumi, Makoto Sano, Satoshi Mogi, Kenichiro Suwa, Hayato Ohtani, Masao Saotome, Tsuyoshi Urushida, and Yuichiro Maekawa
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atrial fibrillation ,catheter ablation ,air embolism ,inspiration-induced negative left atrial pressure ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Atrial fibrillation (AF) ablation is performed under deep sedation, which may cause inspiration-induced negative left atrial pressure (INLAP) associated with deep inspiration. INLAP could be the cause of periprocedural complications. Methods: We retrospectively enrolled 381 patients with AF (mean age, 63.9 ± 10.8 years; 76 women; 216 cases of paroxysmal AF) who underwent CA under deep sedation using an adaptive servo ventilator (ASV). Patients whose LAP was not obtained were excluded. INLAP was defined as 2DS2-Vasc scores (2.3 ± 1.5 vs. 2.1 ± 1.6) and 3% oxygen desaturation indexes (median 18.6 (interquartile range 11.2–31.1) vs. 15.7 (8.1–25.3)), and higher prevalence of diabetes mellitus (23.3 vs. 13.3%) than patients without INLAP. Air embolism occurred in four patients with INLAP (3.0 vs. 0.0%). Conclusion: INLAP is not rare in patients undergoing CA for AF under deep sedation with ASV. Much attention should be paid to the possibility of air embolism in patients with INLAP.
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- 2023
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8. Case Report: Structural Changes in the Coronary Vessel Wall in a Patient With Incomplete Kawasaki Disease
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Takamichi Ishikawa, Hiroki Uchiyama, Satoshi Mogi, and Hayato Ohtani
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Kawasaki disease ,incomplete Kawasaki disease ,optical coherence tomography ,coronary arterial lesion ,intravenous immunoglobulin ,Pediatrics ,RJ1-570 - Abstract
BackgroundKawasaki disease (KD) is an acute systemic vasculitis of infants and young children that affects medium-sized vessels. Conventional cardiac imaging techniques, such as cardiac catheterization, are useful for characterizing the coronary arterial lesion (CAL) size and luminal diameter of the diseased coronary artery segment in patients with KD, but there are limitations to the visualization of the detailed vascular anatomy. Optical coherence tomography (OCT) is a high-resolution intracoronary arterial imaging modality that can distinguish the three layers of the coronary arterial wall. Several studies have reported coronary artery wall abnormalities in KD patients with coronary arterial aneurysm or regressed aneurysm. However, there have been no reports on changes in the coronary artery wall in cases of incomplete KD without CAL.Case PresentationWe herein report an 11-year-old girl with a history of incomplete KD without coronary arterial aneurysms. She had been diagnosed with perimembranous ventricular septal defect (VSD) after birth and had experienced incomplete KD at 1 year old. During her hospitalization for KD, she did not receive intravenous immunoglobulin (IVIG), because she did not meet the Harada score or criteria for treatment in patients with incomplete KD established by the American Heart Association. No dilatation or coronary artery aneurysm were observed on transthoracic echocardiography in the acute or follow-up period. At 11 years old, she received cardiac catheterization and coronary angiography (CAG) for the evaluation of a VSD and follow-up of KD. CAG demonstrated no aneurysm, dilatation, or significant stenosis of the coronary arteries. We performed an OCT study, which revealed the presence of intimal thickening, disruption of the media, and neovascularization in the left anterior descending artery.ConclusionOCT demonstrates the structural changes of CA even in the patient with incomplete KD who have not been treated with IVIG.
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- 2022
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9. Pre-procedural predictors of left atrial low-voltage zones in patients undergoing catheter ablation of atrial fibrillation
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Takenori Ikoma, Yoshihisa Naruse, Yutaro Kaneko, Tomoaki Sakakibara, Taro Narumi, Makoto Sano, Satoshi Mogi, Kenichiro Suwa, Hayato Ohtani, Masao Saotome, Tsuyoshi Urushida, and Yuichiro Maekawa
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Medicine ,Science - Abstract
Pulmonary vein isolation has become a cornerstone treatment for catheter ablation of atrial fibrillation (AF). Recent reports show that additional ablation targeting low-voltage zones reduces AF recurrence. However, the pre-procedural predictors of low-voltage zones remain elusive. We retrospectively enrolled 359 patients (mean age 63.7 ± 10.8 years; 73 females; and 149 had persistent atrial fibrillation) who underwent catheter ablation for AF and left atrial (LA) voltage mapping during sinus rhythm or atrial pacing. Low-voltage zones were defined as area of > 5 cm2 with a bipolar electrogram amplitude of < 0.50 mV. Overall, 51 (14.2%) patients had low-voltage zones. Patients with low-voltage zones were older (67.9 ± 9.9 vs. 63.0 ± 10.8 years; P = 0.003), predominantly female (33.3% vs. 18.2%; P = 0.013), had higher prevalence of dilated cardiomyopathy (DCM) (11.8% vs. 1.6%; P = 0.002) and hypertrophic cardiomyopathy (HCM) (9.8% vs. 2.6%; P = 0.025), and had larger LA volumes (153.6 ± 46.4 vs. 117.7 ± 67.8 mL; P < 0.001) than those without low-voltage zones. Multivariate logistic regression analysis revealed that age (OR 1.060; 95% CI 1.022–1.101, P = 0.002), female sex (OR 2.978; 95% CI 1.340–6.615, P = 0.007), DCM (OR 8.341; 95% CI 1.381–50.372, P = 0.021), HCM (OR 5.044; 95% CI 1.314–19.363, P = 0.018), persistent AF (OR 4.188; 95% CI 1.928–9.100, P < 0.001), and larger LA volume (OR 3.215; 95% CI 1.378–7.502, P = 0.007) were independently associated with the presence of low-voltage zones. Patient age, female sex, DCM, HCM, persistent AF and larger LA volume may predict the presence of low-voltage zones and could be useful in selecting the appropriate ablation strategy for AF.
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- 2022
10. Comparison of delivery catheter-based and stylet-based right ventricular lead placement at the right ventricular septum under fluoroscopic guidance judged by cardiac CT (Mt. FUJI): a study protocol for the Mt. FUJI randomised controlled trial
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Satoru Suwa, Jun Tanabe, Ryo Sugiura, Manabu Ogita, Yoshihisa Naruse, Keisuke Miyajima, Masahiro Muto, Michio Ogano, Nobutake Kurebayashi, Tomoyuki Shiozawa, Yumi Kiyama, Eiko Nagata, Keiichi Odagiri, Yutaro Kaneko, Tomoaki Sakakibara, Taro Narumi, Satoshi Mogi, Kenichiro Suwa, Hayato Ohtani, Masao Saotome, Tuyoshi Urushida, Akira Mizukami, Hideyuki Hasebe, Keisuke Iguchi, Akiko Atsumi, Naoya Inoue, Tomoya Iwawaki, Tomotaka Suzuki, Takashi Ogane, Naoki Tsurumi, Yumiko Joko, Shuji Morikawa, Hideki Wada, Shintaro Takano, Jun Shitara, Shoichiro Yatsu, Taketo Sonoda, Kentaro Yasuda, Ryota Nishio, Daigo Takahashi, Go Ishikawa, Soushi Moriya, Kei Kimura, Kohei Sawasaki, Natsuko Hosoya, Yasushi Wakabayashi, Yoshitaka Kawaguchi, Tomoyuki Watanabe, Yasuyo Takashima, Ayako Okazaki, Kazuki Ito, Ryuta Henmi, Daichi Isomura, Hideki Saito, and Yoshinobu Kato
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Medicine - Abstract
Introduction Pacing-induced cardiomyopathy occasionally occurs in patients undergoing pacemaker implantation. Although compared with right ventricular (RV) apical pacing, RV septal pacing can attenuate left ventricular dyssynchrony; the success rate of lead placement on the RV septum using the stylet system is low. Additionally, no randomised controlled trial has addressed the issue regarding the accuracy of RV lead placement on the RV septum using the stylet and delivery catheter systems. This study hypothesises that a newly available delivery catheter system can improve the accuracy of RV lead placement on the RV septum.Methods and analysis In a multicentre, prospective, randomised, single-blind, controlled trial, 70 patients with pacemaker indication owing to atrioventricular block will be randomised to either the delivery catheter or stylet group before the pacemaker implantation procedure. The position of the RV lead tip will be assessed using ECG-gated cardiac CT in all patients within 4 weeks after pacemaker implantation. Lead tip positions are classified into three groups: (1) RV septum, (2) anterior/posterior edge of the RV septal wall and (3) RV free wall. The primary endpoint will be the success rate of RV lead tip placement on the RV septum, which will be evaluated using cardiac CT.Ethics and dissemination This study will be conducted according to the stipulations of the Helsinki Declaration and the institutional review board of Hamamatsu University School of Medicine. The results of the study will be disseminated at several research conferences and will be published in peer-reviewed journals.Trial registration number jRCTs042200014; Pre-results.
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- 2021
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11. Association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention.
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Ryota Sato, Keitaro Akita, Takenori Ikoma, Keisuke Iguchi, Takayo Murase, Takashi Nakamura, Seigo Akari, Satoshi Mogi, Yoshihisa Naruse, Hayato Ohtani, and Yuichiro Maekawa
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Medicine ,Science - Abstract
ObjectivesReactive oxygen species generated by xanthine oxidoreductase (XOR) are associated with the progression of atherosclerosis. However, changes in plasma XOR (pXOR) activity after percutaneous coronary intervention (PCI) for stable coronary artery disease (CAD) remains unknown.MethodsHerein, we compared the change in the pXOR activity in patients undergoing PCI with that in patients undergoing coronary angiography (CAG) and further evaluated the relation between changes in pXOR activity and in-hospital and long-term outcomes of patients undergoing PCI. The pXOR activity of 80 consecutive patients who underwent PCI and 25 patients who underwent CAG during the hospitalization was analyzed daily. The percentage changes from baseline regulated time interval was evaluated.ResultsWe found that although pXOR activity decreased after PCI, and remained low until discharge, no significant changes were observed in patients undergoing CAG. Furthermore, among the patients undergoing PCI, those who experienced in-hospital adverse events, had a higher percentage of pXOR reduction 3 days after PCI. There was no association between these changes and long-term events.ConclusionsA significant change in pXOR activity was observed in patients undergoing PCI than in patients undergoing CAG, and there seems to be a correlation between the in-hospital outcomes and the percentage reduction from baseline in pXOR activity.
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- 2021
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12. Recurrent Coronary Thrombus in a Patient with Chronic Immune Thrombocytopenia with Treatment Using Eltrombopag
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Terumori Satoh, Masao Saotome, Kenichiro Suwa, Hayato Ohtani, Yasuyuki Nagata, Takaaki Ono, and Yuichiro Maekawa
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background. Eltrombopag, a nonpeptide thrombopoietin receptor agonist (TPO-RA), has been reported to be an effective therapy for chronic immune thrombocytopenia (ITP). However, a higher incidence of arterial and venous thromboembolic events was reported after using eltrombopag. Case Presentation. A 67-year-old man, treated with eltrombopag due to chronic ITP, was admitted due to acute coronary syndrome (ACS). Although coronary angiography revealed no occlusion, cardiac magnetic resonance imaging suggested a myocardial infarction in the territory of the left circumflex coronary artery. Three months after the ACS event, the obtuse marginal branches exhibited significant stenosis; hence, a percutaneous coronary intervention (PCI) was performed to implant a zotarolimus-eluting stent under the treatment of a dual antiplatelet therapy. However, stent thrombosis occurred 3 hours after PCI and required three other PCIs during the eltrombopag treatment. Conclusion. We present a case of an ITP patient, who experienced repeated coronary and stent thrombosis during the treatment with eltrombopag. We propose that the risk of ACS and consequent coronary stent thrombosis should be considered before the introduction of eltrombopag.
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- 2019
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13. Nonbacterial Thrombotic Endocarditis Caused by Early-stage Lung Cancer: An Autopsy Case Report.
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Tomoaki Nagao, Atsushi Sakamoto, Mayu Fujihiro, Rika Kawakami, Kenichiro Suwa, Kazuya Hattori, Hayato Ohtani, Masao Saotome, Satoshi Baba, Aloke V. Finn, and Yuichiro Maekawa
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- 2024
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14. Features and Outcomes of Histologically Proven Myocarditis With Fulminant Presentation
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Koshiro Kanaoka, Kenji Onoue, Satoshi Terasaki, Tomoya Nakano, Michikazu Nakai, Yoko Sumita, Kinta Hatakeyama, Fumio Terasaki, Rika Kawakami, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Yoshihiko Saito, Satoshi Yuda, Masaya Tanno, Toru Takahashi, Hisashi Yokoshiki, Masahiro Toba, Toshihisa Anzai, Toshiyuki Nagai, Takuma Sato, Takashi Takenaka, Seiji Yamazaki, Yuki Katagiri, Toshiharu Takeuchi, Kazuya Sugitatsu, Shigeo Kakinoki, Tomoaki Matsumoto, Kazushi Urasawa, Michinao Tan, Ichizo Tsujino, Mitsunori Kamigaki, Hirofumi Tomita, Kenji Hanada, Motoi Kushibiki, Akihiro Nakamura, Yoshihiro Morino, Takahito Nasu, Satoshi Yasuda, Hideaki Suzuki, Kaoru Iwabuchi, Kanako Tsuji, Shigeto Namiuchi, Tatsuya Komaru, Masahiro Yagi, Shoko Uematsu, Toshiaki Takahashi, Satoru Takeda, Toru Nakanishi, Masafumi Watanabe, Masahiro Wanezaki, Motoyuki Matsui, Shigeo Sugawara, Yasuchika Takeishi, Masayoshi Oikawa, Nobuo Komatsu, Satoshi Suzuki, Hiroshi Okamoto, Noriyuki Takeyasu, Daiki Akiyama, Yutaka Eki, Tsunekazu Kakuta, Tomoyo Sugiyama, Tomomi Koizumi, Koji Ueno, Kazuomi Kario, Mizuri Taki, Yuri Matsumoto, Takanori Yasu, Osamu Nishioka, Shigeto Naito, Makoto Murata, Shoichi Tange, Katsumi Kaneko, Makoto Muto, Hiroshi Inagaki, Shuichi Hasegawa, Eizo Tachibana, Wataru Atsumi, Masahiro Suzuki, Toshihiro Muramatsu, Yoshihiro Yamada, Isao Taguchi, Yoshiaki Fukuda, Akihiro Matsui, Junji Kanda, Koji Hozawa, Akihiko Matsumura, Wataru Shimizu, Takeshi Yamamoto, Issei Komuro, Masaru Hatano, Takanori Ikeda, Shunsuke Kiuchi, Taishiro Chikamori, Yasuyoshi Takei, Kyoko Soejima, Toshinori Minamishima, Hiroyuki Tanaka, Shigeo Shimizu, Masashi Kasao, Tadayuki Kadohira, Tohru Minamino, Kazunori Shimada, Hiroshi Iwata, Yukihiko Momiyama, Takashi Ashikaga, Toshihiro Nozato, Yasumasa Fujiwara, Kenji Inoue, Tetsuo Sasano, Junji Matsuda, Yasuhiro Ishii, Yuichi Ono, Kengo Tanabe, Yu Horiuchi, Toshiro Shinke, Yusuke Kodama, Masao Moroi, Yoshiyuki Yazaki, Taisuke Mizumura, Hiroshi Ohta, Yoshihiro Akashi, Nozomi Kotoku, Yuji Ikari, Mitsunori Maruyama, Yasuhiro Sato, Koichi Tamura, Masaaki Konishi, Hiroshi Suzuki, Mio Ebato, Kazuki Fukui, Kazuhiko Yumoto, Takamasa Iwasawa, Takeshi Kashimura, Kazuyoshi Takahashi, Yoshinobu Okada, Bunji Kaku, Kazuo Usuda, Michiro Maruyama, Tomoki Kameyama, Toshinori Higashikata, Akihiko Hodatsu, Kazuo Osato, Yoji Nagata, Koji Maeno, Kazuo Satake, Takao Sawanobori, Noboru Watanabe, Koichiro Kuwahara, Hirohiko Motoki, Hiroshi Kitabayashi, Kyuhachi Otagiri, Tsunesuke Kono, Daisuke Yamagishi, Yoshikazu Yazaki, Toshiyuki Noda, Itsuro Morishima, Naoki Watanabe, Shinichiro Tanaka, Tomoya Onodera, Ryuzo Nawada, Akinori Watanabe, Masaki Matsunaga, Satoru Suwa, Hiroshi Sakamoto, Hiroki Sakamoto, Takeshi Aoyama, Norio Kanamori, Masahiro Muto, Yuichiro Maekawa, Hayato Ohtani, Yukio Ozaki, Kenshin Naruse, Kenji Takemoto, Haruo Kamiya, Takeshi Suzuki, Yasushi Tomita, Susumu Suzuki, Ryosuke Kametani, Hidekazu Aoyama, Hiroyuki Osanai, Ken Harada, Kenji Kada, Tomoaki Saeki, Koichi Kobayashi, Yasuhiro Ogawa, Akihiro Terasawa, Masanori Shinoda, Mitsutoshi Oguri, Kiyokazu Shimizu, Akinori Sawamura, Atsushi Sugiura, Kosuke Hattori, Shinji Mokuno, Kazuhisa Kondo, Kaoru Dohi, Keishi Moriwaki, Atsunobu Kasai, Tetsuya Nakakuki, Kazuaki Kaitani, Toshikazu Jinnai, Takashi Yamamoto, Hiroyuki Kurata, Atsuyuki Wada, Masaharu Akao, Yasuhiro Hamatani, Kazuya Ishibashi, Yoshiki Akakabe, Yasuhide Asaumi, Hideo Matama, Yasushi Sakata, Hidetaka Kioka, Hiroshi Takaishi, Toru Takase, Mitsuo Matsuda, Fumi Sato, Shinji Hasegawa, Kenichi Ishigami, Minoru Ichikawa, Takashi Takagi, Moriaki Inoko, Masaaki Hoshiga, Shuichi Fujita, Yoshihiro Takeda, Takahiko Kawarabayashi, Hideyuki Takaoka, Kenji Nakajima, Tadashi Yuguchi, Tatsuya Kawasaki, Yukinori Shinoda, Yukihito Sato, Masaharu Ishihara, Yuki Matsumoto, Hiroya Kawai, Tomofumi Takaya, Kouki Matsuo, Toshiaki Mano, Kenichi Hirata, Eriko Hisamatsu, Nobutaka Inoue, Koichi Tamita, Naoki Mukohara, Hisashi Shimoyama, Toru Miyajima, Toshihiro Tamura, Yodo Tamaki, Megumi Suzuki, Ryoji Yokota, Manabu Horii, Kazuo Yamanaka, Hiroyuki Kawata, Yukihiro Hashimoto, Yasuki Nakada, Hitoshi Nakagawa, Tomoya Ueda, Taku Nishida, Ayako Seno, Makoto Watanabe, Takashi Akasaka, Takashi Tanimoto, Mamoru Toyofuku, Kazuhiro Yamamoto, Yoshiharu Kinugasa, Masayuki Hirai, Hiroshi Nasu, Kinya Shirota, Tsuyoshi Oda, Takefumi Oka, Kazushige Kadota, Masanobu Ohya, Hiroshi Ito, Kazufumi Nakamura, Soichiro Ogura, Soichiro Fuke, Shiro Uemura, Hiromi Matsubara, Atsuyuki Watanabe, Nobuyuki Morishima, Yasuki Kihara, Takayuki Hidaka, Hironori Ueda, Yujiro Ono, Yuji Muraoka, Miyo Hatanari, Yoshinori Miyamoto, Keigo Dote, Masaya Kato, Masafumi Yano, Mamoru Mochizuki, Yasuhiro Ikeda, Hiroyuki Fujinaga, Shinobu Hosokawa, Masataka Sata, Koji Yamaguchi, Naoko Aki, Tetsuo Minamino, Yuichi Miyake, Yuichiro Takagi, Masayuki Doi, Yoshio Taketani, Hideki Okayama, Tatsuya Shigematsu, Akinori Higaki, Osamu Yamaguchi, Shinji Inaba, Shuntaro Ikeda, Kazuya Kawai, Hiroaki Kitaoka, Toru Kubo, Kenji Ando, Kaoru Inui, Yoshihiro Fukumoto, Kensuke Hori, Takehiro Homma, Tomohiro Kawasaki, Masahiro Mohri, Masaki Fujiwara, Hiroyuki Tsutsui, Tomomi Ide, Shin-Ichiro Miura, Takashi Kuwano, Hideki Shimomura, Toshiaki Kadokami, Masanao Taba, Katsuhiro Kondou, Toru Kubota, Daisuke Nagatomo, Yasushi Mukai, Ryuichi Matsukawa, Hideki Tashiro, Mitsuhiro Shimomura, Koji Maemura, Hiroaki Kawano, Koji Oku, Toshihiko Yamasa, Yoshihisa Kizaki, Tomohiro Sakamoto, Yudai Tamura, Teruhiko Ito, Kazuteru Fujimoto, Kenichi Tsujita, Seiji Takashio, Hirofumi Kurokawa, Naohiko Takahashi, Shotaro Saito, Masaya Arikawa, Yoshisato Shibata, Kensaku Nishihira, Toshihiro Tsuruda, Masahiro Sonoda, Nobuhiko Atsuchi, Mitsuru Ohishi, Koji Higuchi, Masaaki Miyata, Naoya Oketani, Yoshinori Akimoto, Tomohiro Asahi, and Minoru Wake
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Male ,Myocarditis ,Physiology (medical) ,Humans ,Heart Transplantation ,Female ,Arrhythmias, Cardiac ,Middle Aged ,Prognosis ,Cardiology and Cardiovascular Medicine ,Retrospective Studies - Abstract
Background: Fulminant myocarditis presentation (FMP) is a rare and severe presentation of myocarditis. The natural history of FMP and its clinical features associated with poor outcomes are incompletely understood because there is a lack of generalizable evidence. Methods: This multicenter retrospective cohort study included patients hospitalized with histologically proven myocarditis who underwent catecholamine or mechanical support from 235 cardiovascular training hospitals across Japan between April 2012 and March 2017. Clinical features and the prognostic predictors of death or heart transplantation within 90 days on the basis of clinical and pathologic findings were determined using the Kaplan-Meier method, log-rank test, and Cox regression analysis. Results: This study included 344 patients with histologically proven FMP (median age, 54 years; 40% female). The median follow-up was 600 days (interquartile range, 36 to 1599 days) and the cumulative risk of death or heart transplantation at 90 days was 29% (n=98). Results from multivariable Cox regression analysis showed that older age, nonsinus rhythm, low left ventricular wall motion ( Conclusions: The results from analyses of data from this multicenter registry demonstrated that patients with FMP are at a higher risk of death or heart transplantation in real-world settings. These observations inform which clinical and pathologic findings may be useful for prognostication in FMP. Registration: URL: https://www.umin.ac.jp/ctr ; Unique identifier: UMIN000039763.
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- 2022
15. Pulmonary Tumor Thrombotic Microangiopathy Caused by Metastatic Ovarian Cancer: An Antemortem Diagnosis with Pulmonary Aspiration Cytopathology.
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Kyoko Unno, Hayato Ohtani, Atsushi Sakamoto, Hirotake Murakami, Haruna Yagi, Hiroaki Ito, Satoshi Baba, Toshihide Iwashita, Isao Kosugi, and Yuichiro Maekawa
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- 2023
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16. A Heuristic Approach for Integrated Nesting and Scheduling in Sheet Metal Processing.
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Tatsuhiko Sakaguchi, Hayato Ohtani, and Yoshiaki Shimizu
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- 2015
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17. Association of an Increased Abnormal Mitochondria Ratio in Cardiomyocytes with a Prolonged Oxygen Uptake Time Constant during Cardiopulmonary Exercise Testing of Patients with Non-ischemic Cardiomyopathy
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Takenori, Ikoma, Taro, Narumi, Keitaro, Akita, Ryota, Sato, Takayuki, Masuda, Hanami, Kaneko, Masahiro, Toda, Satoshi, Mogi, Makoto, Sano, Kenichiro, Suwa, Yoshihisa, Naruse, Hayato, Ohtani, Masao, Saotome, and Yuichiro, Maekawa
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Internal Medicine ,General Medicine - Abstract
Objective The cardiac function, blood distribution, and oxygen extraction in the muscles as well as the pulmonary function determine the oxygen uptake (VO
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- 2023
18. A Case of Pulmonary Tumor Thrombotic Microangiopathy Caused by Metastatic Ovarian Cancer: An Antemortem Diagnosis with Pulmonary Aspiration Cytopathology
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Kyoko Unno, Hayato Ohtani, Atsushi Sakamoto, Hirotake Murakami, Haruna Yagi, Hiroaki Ito, Satoshi Baba, Toshihide Iwashita, Isao Kosugi, and Yuichiro Maekawa
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Internal Medicine ,General Medicine - Published
- 2023
19. Nonbacterial Thrombotic Endocarditis Caused by Early-stage Lung Cancer: An Autopsy Case Report
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Tomoaki Nagao, Atsushi Sakamoto, Mayu Fujihiro, Rika Kawakami, Kenichiro Suwa, Kazuya Hattori, Hayato Ohtani, Masao Saotome, Satoshi Baba, Aloke V. Finn, and Yuichiro Maekawa
- Subjects
Internal Medicine ,General Medicine - Published
- 2023
20. Drug-refractory Heart Failure in Female Carrier of Duchenne Muscular Dystrophy: A Case of X-linked Dilated Cardiomyopathy.
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Hayato Ohtani, Masao Saotome, Atsushi Sakamoto, Kenichiro Suwa, and Yuichiro Maekawa
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- 2023
- Full Text
- View/download PDF
21. Diagnostic value of heart-to-mediastinum ratio in 99mTc-pyrophospate SPECT/CT for transthyretin cardiac amyloidosis
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Takenori Ikoma, Hayato Ohtani, Kazuto Ohno, Keisuke Iguchi, Kenichiro Suwa, Michifumi Sawada, Yukichi Tanahashi, Atsushi Sakamoto, Masao Saotome, Shintaro Ichikawa, Satoshi Goshima, and Yuichiro Maekawa
- Subjects
Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine - Published
- 2022
22. Drug-refractory Heart Failure in Female Carrier of Duchenne Muscular Dystrophy: A Case of X-linked Dilated Cardiomyopathy
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Hayato Ohtani, Masao Saotome, Atsushi Sakamoto, Kenichiro Suwa, and Yuichiro Maekawa
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Internal Medicine ,General Medicine - Abstract
A 56-year-old woman was referred to our hospital for the further evaluation of drug-refractory heart failure with a reduced ejection fraction. A family history interview revealed that men in her family had died of Duchenne muscular dystrophy (DMD), whereas she had no skeletal muscle disorder. Myocardial histopathology revealed a reduced dystrophin expression in the cardiomyocyte membrane, and a dystrophin (DMD) gene analysis identified a duplication in exon 8-9 on Xp21, suggesting that she had a cardiac-specific phenotype of dystrophinopathy, i.e. X-linked dilated cardiomyopathy (XLDCM). In conclusion, careful family history interviews and an investigation of dystrophinopathy are required to detect XLDCM in women.
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- 2022
23. Safety of a Cardiac Resynchronization Therapy Device Implantation in a Patient with Unstable Heart Failure Who Require Impella-Device Assistance
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Kyoko Unno, Makoto Sano, Yutaro Kaneko, Keitaro Akita, Tomoaki Sakakibara, Ryota Sato, Taro Narumi, Keisuke Iguchi, Satoshi Mogi, Kenichiro Suwa, Yoshihisa Naruse, Hayato Ohtani, Masao Saotome, Tsuyoshi Urushida, and Yuichiro Maekawa
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Cardiac Resynchronization Therapy ,Heart Failure ,Treatment Outcome ,Heart Ventricles ,Humans ,General Medicine ,Cardiac Resynchronization Therapy Devices ,Cardiology and Cardiovascular Medicine - Abstract
Implantation of a cardiac resynchronization therapy (CRT) device is usually scheduled in the compensated phase of heart failure; however, procedural safety may be sometimes disturbed in the decompensated phase. We report a case of a successful semi-urgent implantation of a CRT device temporary assisted with Impella in a patient with the decompensated phase of severe heart failure dependent on inotropic agents and who cannot maintain the supine position. Impella assistance with left ventricular (LV) unloading and maintenance of end-organ perfusion contributed to early recovery from acute heart failure. Furthermore, an acute effect of mechanical resynchronization by biventricular pacing plays an important role in weaning from the mechanical support or inotropic dependence. These mutual effects of mechanical support and CRT might contribute to a decrease in LV end-diastolic pressure and to a remarkable early recovery from a severely decompensated condition.
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- 2022
24. Individualised left anterior oblique projection for lead implantation into interventricular septum
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Taro Narumi, Yoshihisa Naruse, Yutaro Kaneko, Tomoaki Sakakibara, Makoto Sano, Satoshi Mogi, Kenichiro Suwa, Hayato Ohtani, Tsuyoshi Urushida, Masao Saotome, and Yuichiro Maekawa
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Electrocardiography ,Heart Ventricles ,Humans ,Prospective Studies ,Ventricular Septum ,Cardiology and Cardiovascular Medicine ,Retrospective Studies - Abstract
ObjectiveWe sought to investigate whether it is possible to obtain individualised left anterior oblique (LAO) by preprocedural electrocardiographic parameters and, if so, whether these parameters can help to improve the success rate of right ventricular (RV) lead implantation into the interventricular septum.MethodsIn this observational study, we assessed the relationship between preoperative electrocardiographic parameters and the angle of the interventricular septum obtained using thoracic CT. The participants were divided into two groups: a retrospective derivation cohort to derive the optimal formula for the individual septum axis, and a prospective internal validation cohort to which we applied the optimal formula and implanted using the new method.ResultsIn the retrospective derivation cohort (n=39), the mean angle of individualised LAO assessed by thoracic CT was 53.1°±8.9°, and the preoperative ECG QRS axis was strongly correlated with the interventricular septum axis (R2=0.490). LAO projection derived from the preoperative ECG QRS axis confirmed that the RV lead was placed in the interventricular septum during the pacemaker procedure in the prospective internal validation group (n=30). The success rate for placing the RV lead into the interventricular septum was significantly improved in the internal validation cohort (93% vs 64%, pConclusionsIndividualised LAO angle derived from the preoperative ECG QRS axis is a new useful and simple method for RV lead implantation into the interventricular septum.Trial registration numberUMIN000045741.
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- 2022
25. Clinical Therapy in Patients with Aborted Sudden Cardiac Death due to Coronary Spasm
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Hitoshi Nakagawa, Hirofumi Tomita, Naohiko Takahashi, Kenji Ando, Katsuhito Yamamoto, Masaharu Ishihara, Junya Shite, Koichi Nakao, Masanobu Ishii, Osamu Yamaguchi, Yoshio Kobayashi, Shuntaro Ikeda, Fumie Nishizaki, Tohru Masuyama, Kazuo Kimura, Kenichi Tsujita, Yuichiro Maekawa, Tsuyoshi Miyaji, Shigeru Nakamura, Ritsu Yoshida, Eiji Taguchi, Issei Komuro, Takahiko Kiyooka, Kazuo Kitamura, Akiyoshi Kakutani, Hiroki Teragawa, Masahiro Sasai, Yasuhiro Sasaki, Koichi Kaikita, Yoshihiko Saito, Nobuaki Kobayashi, Tetsunori Ishikawa, Yoshinao Ishii, Tsuyoshi Oda, Toshihiro Shoji, Hiroshi Asajima, Hiroyuki Fujinaga, Yoshihiro Iwasaki, Takashi Nakayama, Hiroshi Suzuki, Kazushige Kadota, Hayato Ohtani, Shozo Sueda, Kazuo Usuda, Daiki Sunada, Takahiro Imanaka, Tetsuzo Wakatsuki, Yutaka Ogino, Masaru Yamaki, Yoshiyuki Kijima, Tetsuji Shinohara, Shoichi Kuramitsu, Yoshihiko Seino, and Masaharu Akao
- Subjects
medicine.medical_specialty ,business.industry ,medicine.drug_class ,medicine.medical_treatment ,General Medicine ,Calcium channel blocker ,Implantable cardioverter-defibrillator ,medicine.disease ,Sudden cardiac death ,Clinical therapy ,Internal medicine ,medicine ,Cardiology ,In patient ,Coronary vasodilator ,business - Published
- 2020
26. Alcohol Septal Ablation for Worsening Heart Failure After Transcatheter Aortic Valve Replacement With Self-Expandable Valve
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Keitaro Akita, Yuichi Suzuki, Ryota Sato, Kenichiro Suwa, Keisuke Iguchi, Satoshi Mogi, Hayato Ohtani, and Yuichiro Maekawa
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Heart Failure ,Transcatheter Aortic Valve Replacement ,Treatment Outcome ,Aortic Valve ,Heart Valve Prosthesis ,Humans ,Aortic Valve Stenosis ,Prosthesis Design ,Cardiology and Cardiovascular Medicine - Published
- 2022
27. Pre-procedural predictors of left atrial low-voltage zones in patients undergoing catheter ablation of atrial fibrillation
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Takenori Ikoma, Yoshihisa Naruse, Yutaro Kaneko, Tomoaki Sakakibara, Taro Narumi, Makoto Sano, Satoshi Mogi, Kenichiro Suwa, Hayato Ohtani, Masao Saotome, Tsuyoshi Urushida, and Yuichiro Maekawa
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Multidisciplinary ,Cardiomyopathy, Hypertrophic ,Middle Aged ,Treatment Outcome ,Pulmonary Veins ,Recurrence ,Atrial Fibrillation ,Catheter Ablation ,Humans ,Female ,Heart Atria ,Electrophysiologic Techniques, Cardiac ,Aged ,Retrospective Studies - Abstract
Pulmonary vein isolation has become a cornerstone treatment for catheter ablation of atrial fibrillation (AF). Recent reports show that additional ablation targeting low-voltage zones reduces AF recurrence. However, the pre-procedural predictors of low-voltage zones remain elusive. We retrospectively enrolled 359 patients (mean age 63.7 ± 10.8 years; 73 females; and 149 had persistent atrial fibrillation) who underwent catheter ablation for AF and left atrial (LA) voltage mapping during sinus rhythm or atrial pacing. Low-voltage zones were defined as area of > 5 cm2 with a bipolar electrogram amplitude of < 0.50 mV. Overall, 51 (14.2%) patients had low-voltage zones. Patients with low-voltage zones were older (67.9 ± 9.9 vs. 63.0 ± 10.8 years; P = 0.003), predominantly female (33.3% vs. 18.2%; P = 0.013), had higher prevalence of dilated cardiomyopathy (DCM) (11.8% vs. 1.6%; P = 0.002) and hypertrophic cardiomyopathy (HCM) (9.8% vs. 2.6%; P = 0.025), and had larger LA volumes (153.6 ± 46.4 vs. 117.7 ± 67.8 mL; P < 0.001) than those without low-voltage zones. Multivariate logistic regression analysis revealed that age (OR 1.060; 95% CI 1.022–1.101, P = 0.002), female sex (OR 2.978; 95% CI 1.340–6.615, P = 0.007), DCM (OR 8.341; 95% CI 1.381–50.372, P = 0.021), HCM (OR 5.044; 95% CI 1.314–19.363, P = 0.018), persistent AF (OR 4.188; 95% CI 1.928–9.100, P < 0.001), and larger LA volume (OR 3.215; 95% CI 1.378–7.502, P = 0.007) were independently associated with the presence of low-voltage zones. Patient age, female sex, DCM, HCM, persistent AF and larger LA volume may predict the presence of low-voltage zones and could be useful in selecting the appropriate ablation strategy for AF.
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- 2021
28. Cardiotoxicity of Carfilzomib in Two Japanese Patients with Relapsed Multiple Myeloma
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Yasuyuki Nagata, Makoto Sano, Yoshihisa Naruse, Tsuyoshi Urushida, Masao Saotome, Takaaki Ono, Takenori Ikoma, Hayato Ohtani, Yuichiro Maekawa, and Kenichiro Suwa
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Oncology ,Male ,medicine.medical_specialty ,Poor prognosis ,Case Report ,Antineoplastic Agents ,030204 cardiovascular system & hematology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Recurrence ,Internal medicine ,Internal Medicine ,medicine ,Humans ,In patient ,Multiple myeloma ,Heart Failure ,Cardiotoxicity ,carfilzomib ,cardiotoxity ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,Carfilzomib ,multiple myeloma ,chemistry ,Hematological malignancy ,Heart failure ,Proteasome inhibitor ,030211 gastroenterology & hepatology ,Female ,business ,Oligopeptides ,Proteasome Inhibitors ,medicine.drug - Abstract
Although multiple myeloma (MM) had been an incurable hematological malignancy with a poor prognosis, recent advances in novel anti-neoplastic agents, including carfilzomib (a proteasome inhibitor), have improved the prognosis. We herein report two cases of congestive heart failure in patients treated with carfilzomib. Although there are some reports on the cardiotoxicity of carfilzomib, to our knowledge, this is the first report on the cardiac involvement of carfilzomib in Japanese MM patients. We review the critical points from our two cases, with the aim of avoiding carfilzomib-associated heart failure in MM patients.
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- 2019
29. Gallbladder Torsion Successfully Treated after Balloon Aortic Valvuloplasty for Severe Aortic Stenosis by Subsequent Open Cholecystectomy—A Case Report
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Makoto Takeda, Hayato Ohtani, Hiroya Takeuchi, Kazuto Katahashi, Takanori Sakaguchi, Yoshifumi Morita, and Ryota Kiuchi
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Gallbladder ,General Engineering ,Open cholecystectomy ,Torsion (gastropod) ,medicine.disease ,Balloon ,Surgery ,Aortic valvuloplasty ,Stenosis ,medicine.anatomical_structure ,General Earth and Planetary Sciences ,Medicine ,business ,General Environmental Science - Published
- 2019
30. Observational Treatment of Internal Thoracic Artery Graft Dissection
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Keitaro Akita, Atsushi Sakamoto, Yuichiro Maekawa, and Hayato Ohtani
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medicine.medical_specialty ,business.industry ,MEDLINE ,General Medicine ,Internal thoracic artery ,Dissection (medical) ,medicine.disease ,Surgery ,Text mining ,medicine.artery ,Medicine ,Observational study ,business ,Images in Cardiovascular Medicine - Published
- 2021
31. Association between plasma xanthine oxidoreductase activity and in-hospital outcomes in patients with stable coronary artery disease after percutaneous coronary intervention
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Keitaro Akita, Yuichiro Maekawa, Takayo Murase, Takashi Nakamura, Seigo Akari, Satoshi Mogi, Takenori Ikoma, Yoshihisa Naruse, Ryota Sato, Keisuke Iguchi, and Hayato Ohtani
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Male ,Cardiovascular Procedures ,Physiology ,Xanthine Dehydrogenase ,medicine.medical_treatment ,Myocardial Infarction ,Coronary Artery Disease ,Cardiovascular Medicine ,Coronary Angiography ,Vascular Medicine ,Coronary artery disease ,chemistry.chemical_compound ,Medical Conditions ,Ischemia ,Blood plasma ,Medicine and Health Sciences ,Coronary Heart Disease ,Prospective Studies ,Myocardial infarction ,skin and connective tissue diseases ,Aged, 80 and over ,Multidisciplinary ,Middle Aged ,Hospitals ,Body Fluids ,Chemistry ,Blood ,Treatment Outcome ,surgical procedures, operative ,Cardiovascular Diseases ,Research Design ,Physical Sciences ,Cardiology ,Medicine ,Female ,Anatomy ,Research Article ,medicine.medical_specialty ,Clinical Research Design ,Science ,Surgical and Invasive Medical Procedures ,Research and Analysis Methods ,Blood Plasma ,Percutaneous Coronary Intervention ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Adverse effect ,Aged ,business.industry ,Angioplasty ,Chemical Compounds ,Biology and Life Sciences ,Percutaneous coronary intervention ,medicine.disease ,Stable Coronary Artery Disease ,Uric Acid ,Enzyme Activation ,chemistry ,Conventional PCI ,Uric acid ,Adverse Events ,sense organs ,Reactive Oxygen Species ,business ,Coronary Angioplasty ,Acids - Abstract
Objectives Reactive oxygen species generated by xanthine oxidoreductase (XOR) are associated with the progression of atherosclerosis. However, changes in plasma XOR (pXOR) activity after percutaneous coronary intervention (PCI) for stable coronary artery disease (CAD) remains unknown. Methods Herein, we compared the change in the pXOR activity in patients undergoing PCI with that in patients undergoing coronary angiography (CAG) and further evaluated the relation between changes in pXOR activity and in-hospital and long-term outcomes of patients undergoing PCI. The pXOR activity of 80 consecutive patients who underwent PCI and 25 patients who underwent CAG during the hospitalization was analyzed daily. The percentage changes from baseline regulated time interval was evaluated. Results We found that although pXOR activity decreased after PCI, and remained low until discharge, no significant changes were observed in patients undergoing CAG. Furthermore, among the patients undergoing PCI, those who experienced in-hospital adverse events, had a higher percentage of pXOR reduction 3 days after PCI. There was no association between these changes and long-term events. Conclusions A significant change in pXOR activity was observed in patients undergoing PCI than in patients undergoing CAG, and there seems to be a correlation between the in-hospital outcomes and the percentage reduction from baseline in pXOR activity.
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- 2021
32. B-PO02-098 PRE-PROCEDURAL PREDICTORS OF LEFT ATRIAL LOW VOLTAGE ZONES IN PATIENTS UNDERGOING CATHETER ABLATION OF ATRIAL FIBRILLATION
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Taro Narumi, Kenichiro Suwa, Yuichiro Maekawa, Masao Saotome, Makoto Sano, Yutaro Kaneko, Takenori Ikoma, Satoshi Mogi, Tomoaki Sakakibara, Hayato Ohtani, Tsuyoshi Urushida, and Yoshihisa Naruse
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Atrial fibrillation ,Catheter ablation ,medicine.disease ,Left atrial ,Physiology (medical) ,Internal medicine ,Cardiology ,Medicine ,In patient ,Cardiology and Cardiovascular Medicine ,business - Published
- 2021
33. Pre-procedural predictors of left atrial lowvoltage zones in patients undergoing catheter ablation of atrial fibrillation.
- Author
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Takenori Ikoma, Yoshihisa Naruse, Yutaro Kaneko, Tomoaki Sakakibara, Taro Narumi, Makoto Sano, Satoshi Mogi, Kenichiro Suwa, Hayato Ohtani, Masao Saotome, Tsuyoshi Urushida, and Yuichiro Maekawa
- Subjects
ATRIAL fibrillation ,ATRIAL flutter ,CATHETER ablation ,LEFT heart atrium ,LOGISTIC regression analysis ,HYPERTROPHIC cardiomyopathy ,PULMONARY veins - Abstract
Pulmonary vein isolation has become a cornerstone treatment for catheter ablation of atrial fibrillation (AF). Recent reports show that additional ablation targeting low-voltage zones reduces AF recurrence. However, the pre-procedural predictors of low-voltage zones remain elusive. We retrospectively enrolled 359 patients (mean age 63.7 ± 10.8 years; 73 females; and 149 had persistent atrial fibrillation) who underwent catheter ablation for AF and left atrial (LA) voltage mapping during sinus rhythm or atrial pacing. Low-voltage zones were defined as area of > 5 cm2 with a bipolar electrogram amplitude of < 0.50 mV. Overall, 51 (14.2%) patients had low-voltage zones. Patients with low-voltage zones were older (67.9 ± 9.9 vs. 63.0 ± 10.8 years; P = 0.003), predominantly female (33.3% vs. 18.2%; P = 0.013), had higher prevalence of dilated cardiomyopathy (DCM) (11.8% vs. 1.6%; P = 0.002) and hypertrophic cardiomyopathy (HCM) (9.8% vs. 2.6%; P = 0.025), and had larger LA volumes (153.6 ± 46.4 vs. 117.7 ± 67.8 mL; P < 0.001) than those without low-voltage zones. Multivariate logistic regression analysis revealed that age (OR 1.060; 95% CI 1.022-1.101, P = 0.002), female sex (OR 2.978; 95% CI 1.340-6.615, P = 0.007), DCM (OR 8.341; 95% CI 1.381-50.372, P = 0.021), HCM (OR 5.044; 95% CI 1.314-19.363, P = 0.018), persistent AF (OR 4.188; 95% CI 1.928-9.100, P < 0.001), and larger LA volume (OR 3.215; 95% CI 1.378-7.502, P = 0.007) were independently associated with the presence of low-voltage zones. Patient age, female sex, DCM, HCM, persistent AF and larger LA volume may predict the presence of low-voltage zones and could be useful in selecting the appropriate ablation strategy for AF. [ABSTRACT FROM AUTHOR]
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- 2022
- Full Text
- View/download PDF
34. Questionnaire in patients with aborted sudden cardiac death due to coronary spasm in Japan
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Yasuhiro Sasaki, Fumie Nishizaki, Hiroyuki Fujinaga, Tetsunori Ishikawa, Masahiro Sasai, Yasushi Tomita, Tohru Masuyama, Hiroshi Suzuki, Daisuke Sunada, Takashi Nakayama, Katsuhito Yamamoto, Nobuaki Kobayashi, Shuntarou Ikeda, Hitoshi Nakagawa, Masaharu Akao, Yoshihiko Saito, Tsuyoshi Miyaji, Masaharu Ishihara, Yoshinao Ishii, Tetsuji Shinohara, Shozo Sueda, Ritsu Yoshida, Shigeru Nakamura, Osamu Yamaguchi, Akiyoshi Kakutani, Junya Shite, Toshihiro Shoji, Kouichi Nakao, Yoshihiro Iwasaki, Masanobu Ishii, Tsuyoshi Oda, Kazushige Kadota, Kazuo Usuda, Eiji Taguchi, Hiroshi Asajima, Masaru Yamaki, Shoichi Kuramitsu, Hiroki Teragawa, Kenji Andou, Tetsuzo Wakatsuki, Takahiro Imanaka, Yutaka Ogino, Yoshiyuki Kijima, Kazuo Kitamura, Yoshio Kobayashi, Issei Komuro, Naohiko Takahashi, Yoshihiko Seino, Kenichi Tsujita, Kazuo Kimura, Yuichirou Maekawa, Takahiko Kiyooka, Koichi Kaikita, and Hayato Ohtani
- Subjects
medicine.medical_specialty ,Health Knowledge, Attitudes, Practice ,medicine.medical_treatment ,Vasodilator Agents ,Clinical Decision-Making ,Electric Countershock ,Coronary Vasospasm ,030204 cardiovascular system & hematology ,Sudden cardiac death ,03 medical and health sciences ,0302 clinical medicine ,Cardiologists ,Japan ,Internal medicine ,Surveys and Questionnaires ,medicine ,Humans ,cardiovascular diseases ,030212 general & internal medicine ,Healthcare Disparities ,Practice Patterns, Physicians' ,business.industry ,Vascular surgery ,Implantable cardioverter-defibrillator ,medicine.disease ,Cardiac surgery ,Defibrillators, Implantable ,Death, Sudden, Cardiac ,Treatment Outcome ,Ventricular fibrillation ,Pulseless electrical activity ,Cardiology ,Drug Therapy, Combination ,Coronary vasodilator ,Cardiology and Cardiovascular Medicine ,business ,Atrioventricular block - Abstract
We investigated the medical or mechanical therapy, and the present knowledge of Japanese cardiologists about aborted sudden cardiac death (ASCD) due to coronary spasm. A questionnaire was developed regarding the number of cases of ASCD, implantable cardioverter–defibrillator (ICD), and medical therapy in ASCD patients due to coronary spasm. The questionnaire was sent to the Japanese general institutions at random in 204 cardiology hospitals. The completed surveys were returned from 34 hospitals, giving a response rate of 16.7%. All SCD during the 5 years was observed in 5726 patients. SCD possibly due to coronary spasm was found in 808 patients (14.0%) and ASCD due to coronary spasm was observed in 169 patients (20.9%). In 169 patients with ASCD due to coronary spasm, one or two coronary vasodilators was administered in two-thirds of patients [113 patients (66.9%)], while more than 3 coronary vasodilators were found in 56 patients (33.1%). ICD was implanted in 117 patients with ASCD due to coronary spasm among these periods including 35 cases with subcutaneous ICD. Majority of cause of ASCD was ventricular fibrillation, whereas pulseless electrical activity was observed in 18 patients and complete atrioventricular block was recognized in 7 patients. Mean coronary vasodilator number in ASCD patients with ICD was significantly lower than that in those without ICD (2.1 ± 0.9 vs. 2.6 ± 1.0, p
- Published
- 2020
35. P585Intra left ventricular hemodynamics assessed using 4D flow MRI in the patient with left ventricular thrombus
- Author
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T. Urushida, Yuichiro Maekawa, Yoshihisa Naruse, Keitaro Akita, S Mogi, Ryota Sato, Tomoaki Sakakibara, Masao Saotome, Yutaro Kaneko, Kenichiro Suwa, Hayato Ohtani, and Takeji Saitoh
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,Vortex Formation ,business.industry ,Internal medicine ,medicine ,Medical imaging ,Cardiology ,Hemodynamics ,Magnetic resonance imaging ,Left ventricular thrombus ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Early detection of left ventricular mural thrombus (LVT) in patients with reduced ejection fraction (EF) is crucial in prevention of arterial embolism. 3D-cine phase-contrast magnetic resonance imaging (4D flow MRI) can visualize the intra-LV vortex flow in diastole and quantify the maximum flow velocity (Vmax) at the apex. it remains, however, unknown whether 4D flow MRI is useful for detecting LVT. Purpose The purpose of our study is to examine the intra-LV vortex formation and flow velocity in patients with severe LV dysfunction using 4D Flow MRI, and to compare differences in intra-LV flow dynamics between patients with and without LVT. We also examined the diagnostic accuracy to detect LVT by 4D flow MRI. Methods Twenty-nine patients with impaired LV function (LVEF 25.8±7.4%, 62.5±12.3 years old, 24 males, 11 with ischemic cardiomyopathy, 9 with LVT) underwent 4D flow MRI from January 2012 to August 2018 in our institution. Intra-LV vortex size was evaluated as vortex/LV area ratio by streamline imaging (Figure 1). The diagnostic accuracy to predict LVT by vortex size and Vmax at the apex was determined by ROC analysis. Results The vortex was smaller (vortex/LV area ratio; 30.6±7.0% vs. 45.1±9.0%, p Figure 1 Conclusion The smaller size of intra-LV vortex and the lower flow velocity at the LV apex may have association with LVT formation in patients with reduced EF. 4D flow MRI might be useful to predict LVT formation. Large scale longitudinal study is warranted to evaluate the incidence of LVT in the patients with lower flow velocity. Acknowledgement/Funding None
- Published
- 2019
36. Plasma Globotriaosylsphingosine Level as a Primary Screening Target for Fabry Disease in Patients With Left Ventricular Hypertrophy
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Yasushi Wakabayashi, Jun Kajihara, Mamoru Nobuhara, Kei Tawarahara, Hiroshi Satoh, Hideharu Hayashi, Masao Saotome, Azumi Kumazawa, Satoshi Yamashita, Hiroki Maruyama, Kimito Mizuno, Keisuke Miyajima, Yuji Matsumoto, Satoshi Ishii, Tsuyoshi Urushida, Nobuyuki Wakahara, Yusaku Mochizuki, Yuichiro Maekawa, Hajime Terada, Hiroyuki Takase, Hiromutsu Tominaga, Masaki Matsunaga, Makoto Sano, and Hayato Ohtani
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0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Left ventricular hypertrophy ,Ventricular Function, Left ,Endomyocardial biopsy ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Unknown Significance ,Japan ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,In patient ,Genetic Predisposition to Disease ,Prospective Studies ,Aged ,Sphingolipids ,Ventricular Remodeling ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Fabry disease ,030104 developmental biology ,alpha-Galactosidase ,Mutation ,Cardiology ,Chronic renal failure ,Fabry Disease ,Female ,Hypertrophy, Left Ventricular ,Hemodialysis ,Glycolipids ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,Primary screening - Abstract
Background Although previous studies have suggested a certain prevalence of Fabry disease (FD) in left ventricular hypertrophy (LVH) patients, the screening of FD is difficult because of its wide-ranging clinical phenotypes. We aimed to clarify the utility of combined measurement of plasma globotriaosylsphingosine (lyso-Gb3) concentration and α-galactosidase A activity (α-GAL) as a primary screening of FD in unexplained LVH patients.Methods and Results:Between 2014 and 2016, both lyso-Gb3 and α-GAL were measured in 277 consecutive patients (male 215, female 62, age 25-79 years) with left ventricular wall thickness >12 mm on echocardiogram: 5 patients (1.8%) screened positive (2 (0.7%) showed high lyso-Gb3 and 4 (1.4%) had low α-GAL levels). Finally, 2 patients (0.7%) were diagnosed with clinically significant FD. In 1 case, a female heterozygote with normal α-GAL levels had genetic variants of unknown significance and was diagnosed as FD by endomyocardial biopsy. The other case was a male chronic renal failure patient requiring hemodialysis, and he had a p.R112H mutation. In both cases there were high lyso-Gb3 levels. Conclusions The serum lyso-Gb3 level can be relevant for clinically significant FD, and combined measurement of lyso-Gb3 and α-GAL can provide better screening of FD in unexplained LVH patients.
- Published
- 2019
37. Clinical feasibility of pulmonary vein orifice pacing for the prediction of phrenic nerve injury during cryoballoon ablation of atrial fibrillation
- Author
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Tomoaki Sakakibara, Makoto Sano, Yuichiro Maekawa, Masao Saotome, Kenichiro Suwa, Yoshihisa Naruse, Gaku Matsukura, Tsuyoshi Urushida, and Hayato Ohtani
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Male ,medicine.medical_specialty ,Action Potentials ,030204 cardiovascular system & hematology ,Cryosurgery ,Risk Assessment ,Phrenic Nerve Injury ,Pulmonary vein ,03 medical and health sciences ,0302 clinical medicine ,Heart Rate ,Peripheral Nerve Injuries ,Predictive Value of Tests ,Risk Factors ,Physiology (medical) ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,030212 general & internal medicine ,Cryoballoon ablation ,Phrenic nerve ,Aged ,business.industry ,Cardiac Pacing, Artificial ,Atrial fibrillation ,Middle Aged ,medicine.disease ,Evoked Potentials, Motor ,Compound muscle action potential ,Phrenic Nerve ,Catheter ,Treatment Outcome ,Pulmonary Veins ,Cardiology ,Feasibility Studies ,Female ,Cardiology and Cardiovascular Medicine ,Complication ,business ,Electrophysiologic Techniques, Cardiac - Abstract
INTRODUCTION Phrenic nerve (PN) injury is a well-known complication of cryoballoon ablation (CBA) for pulmonary vein (PV) isolation in patients with atrial fibrillation. However, it is still insufficient to practically predict phrenic nerve injury (PNI) before freezing. We hypothesized that phrenic nerve capture (PNC) with phrenic nerve orifice pacing (PVOP) might be a surrogate sign of the close proximity of the PN, and that might predict PNI and changes in the compound motor action potential (CMAP) amplitude. METHODS Seventy patients (60 ± 12 years, male 80%, paroxysmal 56%) underwent PVOP with a 20-electrode ring catheter before the CBA. The clinical outcome was the occurrence of transient and persistent PNI. In addition, the PV position and pacing threshold during PNC with PVOP, and changes in the CMAP amplitude were recorded. We compared these measurements between patients with and without PNC (PNC/non-PNC group) with PVOP. RESULTS PNC with PVOP occurred in 39 (56%) patients and was localized only to the right superior PV. Transient PNI occurred in seven (10%) patients and permanent in none. The CMAP amplitude decreased significantly more in the PNC group (PNC 33% vs non-PNC 16%, P = .027). PNC group had a higher risk of the composite outcome of transient PNI or ≥30% decrease in the CMAP amplitude (PNC 54% vs non-PNC 13%; P
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- 2019
38. Recurrent Coronary Thrombus in a Patient with Chronic Immune Thrombocytopenia with Treatment Using Eltrombopag
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Hayato Ohtani, Masao Saotome, Takaaki Ono, Yasuyuki Nagata, Terumori Satoh, Yuichiro Maekawa, and Kenichiro Suwa
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medicine.medical_specialty ,Acute coronary syndrome ,lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_treatment ,Eltrombopag ,Case Report ,030204 cardiovascular system & hematology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,Coronary stent ,Medicine ,030212 general & internal medicine ,Myocardial infarction ,cardiovascular diseases ,business.industry ,Stent ,Percutaneous coronary intervention ,medicine.disease ,Thrombosis ,chemistry ,lcsh:RC666-701 ,Conventional PCI ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background. Eltrombopag, a nonpeptide thrombopoietin receptor agonist (TPO-RA), has been reported to be an effective therapy for chronic immune thrombocytopenia (ITP). However, a higher incidence of arterial and venous thromboembolic events was reported after using eltrombopag.Case Presentation. A 67-year-old man, treated with eltrombopag due to chronic ITP, was admitted due to acute coronary syndrome (ACS). Although coronary angiography revealed no occlusion, cardiac magnetic resonance imaging suggested a myocardial infarction in the territory of the left circumflex coronary artery. Three months after the ACS event, the obtuse marginal branches exhibited significant stenosis; hence, a percutaneous coronary intervention (PCI) was performed to implant a zotarolimus-eluting stent under the treatment of a dual antiplatelet therapy. However, stent thrombosis occurred 3 hours after PCI and required three other PCIs during the eltrombopag treatment.Conclusion. We present a case of an ITP patient, who experienced repeated coronary and stent thrombosis during the treatment with eltrombopag. We propose that the risk of ACS and consequent coronary stent thrombosis should be considered before the introduction of eltrombopag.
- Published
- 2019
39. Glycogen synthase kinase-3β opens mitochondrial permeability transition pore through mitochondrial hexokinase II dissociation
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Masao Saotome, Yuichiro Maekawa, Hiroshi Satoh, Terumori Satoh, Hideki Katoh, Prottoy Hasan, Hayato Ohtani, Takamitsu Tanaka, and Hideharu Hayashi
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0301 basic medicine ,Cell physiology ,Male ,Physiology ,Ischemia ,Mitochondrial Membrane Transport Proteins ,Mitochondria, Heart ,Permeability ,Rats, Sprague-Dawley ,03 medical and health sciences ,chemistry.chemical_compound ,GSK-3 ,Hexokinase ,medicine ,Myocyte ,Animals ,Myocytes, Cardiac ,Glycogen synthase ,Membrane potential ,Membrane Potential, Mitochondrial ,Glycogen Synthase Kinase 3 beta ,biology ,Chemistry ,Mitochondrial Permeability Transition Pore ,MPTP ,medicine.disease ,Rats ,030104 developmental biology ,Mitochondrial permeability transition pore ,cardiovascular system ,biology.protein ,Biophysics - Abstract
Accumulating evidence has revealed pivotal roles of glycogen synthase kinase-3β (GSK3β) inactivation on cardiac protection. Because the precise mechanisms of cardiac protection against ischemia/reperfusion (I/R) injury by GSK3β-inactivation remain elusive, we investigated the relationship between GSK3β-mediated mitochondrial hexokinase II (mitoHK-II; a downstream target of GSK3β) dissociation and mitochondrial permeability transition pore (mPTP) opening. In Langendorff-perfused hearts, GSK3β inactivation by SB216763 improved the left ventricular-developed pressure and retained mitoHK-II binding after I/R. In permeabilized myocytes, GSK3β depolarized mitochondrial membrane potential with accelerated mitochondrial calcein release (suggesting GSK3β-mediated mPTP opening) and decreased mitoHK-II bindings. GSK3β-mediated mPTP opening depended on mitoHK-II binding, i.e., it was accelerated by dissociation of mitoHK-II (dicyclohexylcarbodiimide) and attenuated by enhancement of mitoHK-II binding (dextran). However, inactivation of mitoHK-II by glucose-depletion or glucose-6-phosphate inhibited the GSK3β-mediated mPTP opening. We conclude that GSK3β-mediated mPTP opening may be involved in I/R injury and regulated by mitoHK-II binding and activity.
- Published
- 2017
40. Genetic Algorithm Based Nesting Method with Considering Schedule for Sheet Metal Processing
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Hayato Ohtani, Tatsuhiko Sakaguchi, and Yoshiaki Shimizu
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Engineering ,business.industry ,visual_art ,visual_art.visual_art_medium ,Artificial intelligence ,Sheet metal ,business ,Machine learning ,computer.software_genre ,Industrial engineering ,computer ,Scheduling (computing) - Published
- 2015
41. Distribution of late gadolinium enhancement in end-stage hypertrophic cardiomyopathy and dilated cardiomyopathy: Differential diagnosis and prediction of cardiac outcome
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Harumi Sakahara, Tsuyoshi Urushida, Hiroshi Ukigai, Kei Tawarahara, Hiroshi Satoh, Masao Saotome, Yasuo Takehara, Yasushi Wakabayashi, Masashi Machii, Hideki Katoh, Hideharu Hayashi, Katsunori Shiraki, and Hayato Ohtani
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Adult ,Cardiomyopathy, Dilated ,Gadolinium DTPA ,Male ,Risk ,medicine.medical_specialty ,Biomedical Engineering ,Biophysics ,Contrast Media ,Magnetic Resonance Imaging, Cine ,Disease-Free Survival ,Diagnosis, Differential ,Internal medicine ,medicine ,Humans ,Distribution (pharmacology) ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Stage (cooking) ,Survival rate ,Aged ,Retrospective Studies ,Ultrasonography ,medicine.diagnostic_test ,business.industry ,Myocardium ,Hypertrophic cardiomyopathy ,Dilated cardiomyopathy ,Magnetic resonance imaging ,Cardiomyopathy, Hypertrophic ,Middle Aged ,medicine.disease ,Echocardiography, Doppler ,Heart failure ,embryonic structures ,cardiovascular system ,Cardiology ,Female ,Differential diagnosis ,business ,Follow-Up Studies - Abstract
Background The prognostic implications of late gadolinium enhancement (LGE) have been evaluated in ischemic and non-ischemic cardiomyopathies. The present study analyzed LGE distribution in patients with end-stage hypertrophic cardiomyopathy (ES-HCM) and with dilated cardiomyopathy (DCM), and tried to identify high risk patients in DCM. Methods Eleven patients with ES-HCM and 72 with DCM underwent cine- and LGE-cardiac magnetic resonance and ultrasound cardiography. The patient outcome was analyzed retrospectively for 5 years of follow-up. Results LGE distributed mainly in the inter-ventricular septum, but spread more diffusely into other left ventricular segments in patients with ES-HCM and in a certain part of patients with DCM. Thus, patients with DCM can be divided into three groups according to LGE distribution; no LGE (n = 24), localized LGE (localized at septum, n = 36), and extensive LGE (spread into other segments, n = 12). Reverse remodeling occurred after treatment in patients with no LGE and with localized LGE, but did not in patients with extensive LGE and with ES-HCM. The event-free survival rate for composite outcome (cardiac death, hospitalization for decompensated heart failure or ventricular arrhythmias) was lowest in patients with extensive LGE (92%, 74% and 42% in no LGE, localized LGE, and extensive LGE, p = 0.02 vs. no LGE), and was comparable to that in patients with ES-HCM (42%). Conclusions In DCM, patients with extensive LGE showed no functional recovery and the lowest event-free survival rate that were comparable to patients with ES-HCM. The analysis of LGE distribution may be valuable to predict reverse remodeling and to identify high-risk patients.
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- 2014
42. TCTAP C-191 Successful Endovascular Therapy of Severe Calcified Lesion in Coronary Artery Disease and Peripheral Artery Disease
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Hayato Ohtani
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Calcified lesion ,Coronary artery disease ,medicine.medical_specialty ,business.industry ,Arterial disease ,Internal medicine ,medicine ,Cardiology ,Disease ,business ,medicine.disease ,Cardiology and Cardiovascular Medicine ,Endovascular therapy - Published
- 2015
- Full Text
- View/download PDF
43. Eicosapentaenoic acid ameliorates palmitate-induced lipotoxicity via the AMP kinase/dynamin-related protein-1 signaling pathway in differentiated H9c2 myocytes
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Masao Saotome, Hayato Ohtani, Terumori Satoh, Hideki Katoh, Prottoy Hasan, Hideharu Hayashi, Tsuyoshi Urushida, Hiroshi Satoh, and Atsushi Sakamoto
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0301 basic medicine ,Dynamins ,medicine.medical_specialty ,Cardiotonic Agents ,Palmitates ,Caspase 3 ,030204 cardiovascular system & hematology ,Biology ,AMP-Activated Protein Kinases ,Cell Line ,03 medical and health sciences ,DNM1L ,0302 clinical medicine ,AMP-activated protein kinase ,Internal medicine ,medicine ,Animals ,AMPK ,Cell Biology ,humanities ,Cell biology ,Rats ,030104 developmental biology ,Endocrinology ,Lipotoxicity ,Eicosapentaenoic Acid ,Apoptosis ,Saturated fatty acid ,biology.protein ,Signal transduction ,Myoblasts, Cardiac ,Signal Transduction - Abstract
Background Emerging evidence suggested the preferable effects of eicosapentaenoic acid (EPA; n-3 polyunsaturated fatty acid) against cardiac lipotoxicity, which worsens cardiac function by means of excessive serum free fatty acids due to chronic adrenergic stimulation under heart failure. Nonetheless, the precise molecular mechanisms remain elusive. In this study, we focused on dynamin-related protein-1 (Drp1) as a possible modulator of the EPA-mediated cardiac protection against cardiac lipotoxicity, and investigated the causal relation between AMP-activated protein kinase (AMPK) and Drp1. Methods and results When differentiated H9c2 myocytes were exposed to palmitate (PAL; saturated fatty acid, 400 µM) for 24 h, these myocytes showed activation of caspases 3 and 7, enhanced caspase 3 cleavage, depolarized mitochondrial membrane potential, depleted intracellular ATP, and enhanced production of intracellular reactive oxygen species. These changes suggested lipotoxicity due to excessive PAL. PAL enhanced mitochondrial fragmentation with increased Drp1 expression, as well. EPA (50 µM) restored the PAL-induced apoptosis, mitochondrial dysfunction, and mitochondrial fragmentation with increased Drp1 expression by PAL. EPA activated phosphorylation of AMPK, and pharmacological activation of AMPK by 5-aminoimidazole-4-carboxamide ribonucleotide ameliorated the PAL-induced apoptosis, mitochondrial dysfunction, and downregulated Drp1. An AMPK knockdown via RNA interference enhanced Drp1 expression and attenuated the protective effects of EPA against the PAL-induced lipotoxicity. Conclusion EPA ameliorates the PAL-induced lipotoxicity via AMPK activation, which subsequently suppresses mitochondrial fragmentation and Drp1 expression. Our findings may provide new insights into the molecular mechanisms of EPA-mediated myocardial protection in heart failure.
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- 2016
44. Intravenous glutathione prevents renal oxidative stress after coronary angiography more effectively than oral N-acetylcysteine
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Masashi Machii, Hideharu Hayashi, Hiroshi Satoh, Takeji Saitoh, Mamoru Nobuhara, Hideki Katoh, Tsuyoshi Urushida, Masao Saotome, Hayato Ohtani, and Takamitsu Tanaka
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Male ,Lipid Peroxides ,medicine.medical_specialty ,Time Factors ,Contrast-induced nephropathy ,Urology ,Administration, Oral ,Contrast Media ,Renal function ,Coronary Angiography ,Kidney ,medicine.disease_cause ,Antioxidants ,Nephropathy ,Acetylcysteine ,chemistry.chemical_compound ,Japan ,Humans ,Medicine ,Prospective Studies ,Infusions, Intravenous ,Aged ,Analysis of Variance ,Chi-Square Distribution ,business.industry ,Kidney metabolism ,Glutathione ,medicine.disease ,Surgery ,Oxidative Stress ,Treatment Outcome ,medicine.anatomical_structure ,chemistry ,Creatinine ,Female ,Kidney Diseases ,Lipid Peroxidation ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,Oxidative stress ,medicine.drug - Abstract
This study proposes the intravenous administration of glutathione (GSH) as a novel strategy to prevent contrast medium-induced renal oxidative stress. Renal oxidative stress is a critical cause of contrast-induced nephropathy (CIN). Recent reports have described that N-acetylcysteine (NAC) may prevent CIN by scavenging reactive oxygen species in the kidney. Twenty-one patients with reduced renal function who underwent coronary angiography (CAG) were equally assigned to the control, NAC and GSH (100 mg/min for 30 min before CAG) groups. CIN occurred in two patients, one in the control and the other in the NAC group. In the control group, the urinary lipid hydroperoxides (LOOHs) increased to 299.5 ± 94.4% of the baseline at 2 h after CAG (mean ± SE, p
- Published
- 2010
45. Local control of mitochondrial membrane potential, permeability transition pore and reactive oxygen species by calcium and calmodulin in rat ventricular myocytes
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Takamitsu Tanaka, Hideki Katoh, Keiichi Odagiri, Hideharu Hayashi, Hiroshi Satoh, Hayato Ohtani, Masao Saotome, Hirotaka Kawashima, and Tsuyoshi Urushida
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Mitochondrial ROS ,animal structures ,SERCA ,Thapsigargin ,biology ,Chemistry ,Cell biology ,Mitochondrial membrane transport protein ,chemistry.chemical_compound ,Mitochondrial permeability transition pore ,Cyclosporin a ,Ca2+/calmodulin-dependent protein kinase ,cardiovascular system ,biology.protein ,Cardiology and Cardiovascular Medicine ,Molecular Biology ,Heart metabolism - Abstract
Calmodulin (CaM) and Ca(2+)/CaM-dependent protein kinase II (CaMKII) play important roles in the development of heart failure. In this study, we evaluated the effects of CaM on mitochondrial membrane potential (DeltaPsi(m)), permeability transition pore (mPTP) and the production of reactive oxygen species (ROS) in permeabilized myocytes; our findings are as follows. (1) CaM depolarized DeltaPsi(m) dose-dependently, but this was prevented by an inhibitor of CaM (W-7) or CaMKII (autocamtide 2-related inhibitory peptide (AIP)). (2) CaM accelerated calcein leakage from mitochondria, indicating the opening of mPTP, however this was prevented by AIP. (3) Cyclosporin A (an inhibitor of the mPTP) inhibited both CaM-induced DeltaPsi(m) depolarization and calcein leakage. (4) CaM increased mitochondrial ROS, which was related to DeltaPsi(m) depolarization and the opening of mPTP. (5) Chelating of cytosolic Ca(2+) by BAPTA, the depletion of SR Ca(2+) by thapsigargin (an inhibitor of SERCA) and the inhibition of mitochondrial Ca(2+) uniporter by Ru360 attenuated the effects of CaM on mitochondrial function. (6) CaM accelerated Ca(2+) extrusion from mitochondria. We conclude that CaM/CaMKII depolarized DeltaPsi(m) and opened mPTP by increasing ROS production, and these effects were strictly regulated by the local increase in cytosolic Ca(2+) concentration, initiated by Ca(2+) releases from the SR. In addition, CaM was involved in the regulation of mitochondrial Ca(2+) homeostasis.
- Published
- 2009
46. A Heuristic Approach for Integrated Nesting and Scheduling in Sheet Metal Processing
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Hayato Ohtani, Yoshiaki Shimizu, and Tatsuhiko Sakaguchi
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Engineering ,business.industry ,Scheduling (production processes) ,Agile manufacturing ,Machine learning ,computer.software_genre ,Industrial engineering ,Bottleneck ,Manufacturing ,visual_art ,Production schedule ,visual_art.visual_art_medium ,Artificial intelligence ,business ,Sheet metal ,computer - Abstract
In recent years, sustainable and agile manufacturing is aimed at in many manufacturing industries. Reducing the waste of raw materials and managing the production schedule are important factors for such manufacturing. Nesting is an activity designing a cutting layout while scheduling is one managing operational procedures. Noting such nesting and scheduling in sheet metal processing, we need to consider those simultaneously for increasing the entire efficiency. This is because there often occurs a trade-off between them. To resolve such problem, we previously proposed an integrated method of nesting and scheduling. In order to enhance the scheduling ability that was insufficient in our method, this study extends the idea through a heuristic approach. Actually, we apply a local search to update the initial schedule which is decided by EDD based dispatching rule and manage it in terms of the criteria referring to the bottleneck process. Computational experiment is provided to validate the effectiveness of the proposed method.
- Published
- 2015
47. TCTAP C-089 A Case of PCI to LAD CTO After Coil Embolization for Coronary Perforation
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Takenori Ikoma and Hayato Ohtani
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medicine.medical_specialty ,surgical procedures, operative ,business.industry ,Perforation (oil well) ,Conventional PCI ,medicine ,cardiovascular diseases ,Radiology ,business ,Cardiology and Cardiovascular Medicine ,Surgery ,Coil embolization - Published
- 2014
- Full Text
- View/download PDF
48. Functional, morphological and electrocardiographical abnormalities in patients with apical hypertrophic cardiomyopathy and apical aneurysm: correlation with cardiac MR
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Yasushi Wakabayashi, Hiroyuki Takase, Hideki Katoh, Hiroshi Satoh, Yasuo Takehara, Tsuyoshi Urushida, Kei Tawarahara, Hideharu Hayashi, Makoto Sano, Masao Saotome, Harumi Sakahara, Mamoru Nobuhara, Kenichiro Suwa, Takeji Saitoh, Hajime Terada, and Hayato Ohtani
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Apical aneurysm ,Pathology ,medicine.medical_specialty ,Contraction (grammar) ,business.industry ,Hypertrophic cardiomyopathy ,Early detection ,Qrs fragmentation ,medicine.disease ,cardiovascular system ,Medicine ,Late gadolinium enhancement ,In patient ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,business ,Heart Failure and Cardiomyopathies - Abstract
Objective The prognosis of apical hypertrophic cardiomyopathy (APH) has been benign, but apical myocardial injury has prognostic importance. We studied functional, morphological and electrocardiographical abnormalities in patients with APH and with apical aneurysm and sought to find parameters that relate to apical myocardial injury. Methods Study design: a multicentre trans-sectional study. Patients: 45 patients with APH and 5 with apical aneurysm diagnosed with transthoracic echocardiography (TTE) in the database of Hamamatsu Circulation Forum. Measure: the apical contraction with cine-cardiac MR (CMR), the myocardial fibrotic scar with late gadolinium enhancement (LGE)-CMR, and QRS fragmentation (fQRS) defined when two ECG-leads exhibited RSR’s patterns. Results Cine-CMR revealed 27 patients with normal, 12 with hypokinetic and 11 with dyskinetic apical contraction. TTE misdiagnosed 11 (48%) patients with hypokinetic and dyskinetic contraction as those with normal contraction. Apical LGE was apparent in 10 (83%) and 11 (100%) patients with hypokinetic and dyskinetic contraction, whereas only in 11 patients (41%) with normal contraction (p
- Published
- 2014
49. Transcatheter closure of right-to-left atrial shunt in patients with platypnea-orthodeoxia syndrome associated with aortic elongation
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Yasufumi Kijima, Teiji Akagi, Manabu Taniguchi, Yoichi Takaya, Shunji Sano, Koji Nakagawa, Hiroshi Ito, and Hayato Ohtani
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Male ,medicine.medical_specialty ,Cardiac Catheterization ,Posture ,Foramen Ovale, Patent ,Heart Septal Defects, Atrial ,medicine.artery ,Internal medicine ,Ascending aorta ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,Hypoxia ,Platypnea orthodeoxia ,Foramen ovale (heart) ,Aged ,Heart septal defect ,medicine.diagnostic_test ,business.industry ,Interventional radiology ,General Medicine ,Syndrome ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Dyspnea ,Echocardiography ,Patent foramen ovale ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Tomography, X-Ray Computed ,Shunt (electrical) - Abstract
Platypnea-orthodeoxia is a rare condition characterized by dyspnea and oxygen desaturation induced by the upright position and relieved by recumbency. The most common cause of this syndrome is right-to-left shunt through interatrial communications such as patent foramen ovale (PFO) or atrial septal defect (ASD). In addition, this syndrome can be caused by other extracardiac components, including pulmonary emphysema, pericardial disease, and prominent Eustachian valve. We experienced 3 cases of this syndrome, including 1 patient with PFO and 2 patients with ASD. Computer tomography imaging revealed aortic elongation and compression of the right atrium by ascending aorta in all of 3 patients. Transcatheter closure of PFO or ASD was successfully performed in all patients, including immediate improvements of symptoms and oxygen saturation without any complications.
- Published
- 2013
50. Effects of nitric oxide on mitochondrial permeability transition pore and thiol-mediated responses in cardiac myocytes
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Tsuyoshi Urushida, Hayato Ohtani, Hideharu Hayashi, Takamitsu Tanaka, Masao Saotome, Hideki Katoh, and Hiroshi Satoh
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Male ,Cancer Research ,Physiology ,animal diseases ,Clinical Biochemistry ,Atractyloside ,Nitric Oxide ,Biochemistry ,Mitochondrial Membrane Transport Proteins ,Dithiothreitol ,Nitric oxide ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Animals ,heterocyclic compounds ,Myocytes, Cardiac ,Cysteine ,Disulfides ,Sulfhydryl Compounds ,Cells, Cultured ,chemistry.chemical_classification ,Membrane Potential, Mitochondrial ,Mitochondrial Permeability Transition Pore ,MPTP ,Nitrosylation ,Ascorbic acid ,NONOate ,nervous system diseases ,Rats ,nervous system ,chemistry ,Mitochondrial permeability transition pore ,cardiovascular system ,Thiol ,Biophysics - Abstract
Nitric oxide (NO) alters the opening of mitochondrial permeability transition pore (mPTP). However, the signaling pathways of NO on mPTP remain elusive. We aimed to clarify the contribution of thiol-mediated responses to the effects of NO on mPTP in permeabilized myocytes. We found that (1) a high concentration of spermine NONOate (an NO donor; 500 μM) opened mPTP and depolarized ΔΨ(m). (2) A low concentration of NONOate (5 μM) prevented atractyloside (an mPTP opener)-induced mPTP opening. (3) Mn(III) tetrakis (4-benzoic acid) porphyrin (Mn-TBAP, ONOO(-) scavenger) attenuated the effect of high-concentration NONOate on mPTP opening, but did not inhibited the preventive effects of low-concentration NONOate. (4) When the interaction of NO with thiol was inhibited by N-ethylmaleimide, the opening (by high-concentration NONOate) and preventive effects (by low-concentration NONOate) of NONOate on mPTP were blocked. (5) Dithiothreitol (an inhibitor of disulfide bonds formation) prevented high-concentration NONOate-induced mPTP opening. (6) Ascorbic acid (an inhibitor of S-nitrosylation) prevented the preventive effects of low-concentration NONOate on mPTP. We conclude that opening of mPTP by high-concentration NO is related to disulfide bonds formation and oxidizing effects of ONOO(-). In contrast, the inhibitory effect of physiological concentrations of NO on mPTP is related to S-nitrosylation.
- Published
- 2011
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