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2. M‐PAST score is better than MAST score for the diagnosis of active fibrotic nonalcoholic steatohepatitis

Author

Imajo, Kento, Saigusa, Yusuke, Kobayashi, Takashi, Nagai, Koki, Nishida, Shinya, Kawamura, Nobuyoshi, Doi, Hiroyoshi, Iwaki, Michihiro, Nogami, Asako, Honda, Yasushi, Kessoku, Takaomi, Ogawa, Yuji, Kirikoshi, Hiroyuki, Yasuda, Satoshi, Toyoda, Hidenori, Hayashi, Hideki, Kokubu, Shigehiro, Utsunomiya, Daisuke, Takahashi, Hirokazu, Aishima, Shinichi, Kim, Beom Kyung, Tamaki, Nobuharu, Saito, Satoru, Yoneda, Masato, Loomba, Rohit, and Nakajima, Atsushi

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Liver Disease, Biomedical Imaging, Hepatitis, Chronic Liver Disease and Cirrhosis, Digestive Diseases, Clinical Research, 4.2 Evaluation of markers and technologies, Oral and gastrointestinal, active fibrotic NASH, F-CAST, FAST, M-PAST, MAST
Abstract

BackgroundClinical trials enroll patients with active fibrotic nonalcoholic steatohepatitis (NASH) (nonalcoholic fatty liver disease [NAFLD] activity score ≥ 4) and significant fibrosis (F ≥ 2); however, screening failure rates are high following biopsy. We developed new scores to identify active fibrotic NASH using FibroScan and magnetic resonance imaging (MRI).MethodsWe undertook prospective primary (n = 176), retrospective validation (n = 169), and University of California San Diego (UCSD; n = 234) studies of liver biopsy-proven NAFLD. Liver stiffness measurement (LSM) using FibroScan or magnetic resonance elastography (MRE), controlled attenuation parameter (CAP), or proton density fat fraction (PDFF), and aspartate aminotransferase (AST) were combined to develop a two-step strategy-FibroScan-based LSM followed by CAP with AST (F-CAST) and MRE-based LSM followed by PDFF with AST (M-PAST)-and compared with FibroScan-AST (FAST) and MRI-AST (MAST) for diagnosing active fibrotic NASH. Each model was categorized using rule-in and rule-out criteria.ResultsAreas under receiver operating characteristic curves (AUROCs) of F-CAST (0.826) and M-PAST (0.832) were significantly higher than those of FAST (0.744, p = 0.004) and MAST (0.710, p

Published
2023

10. Accuracy of the Enhanced Liver Fibrosis Test in Patients With Type 2 Diabetes Mellitus and Its Clinical Implications

Author

Arai, Taeang, Takahashi, Hirokazu, Seko, Yuya, Toyoda, Hidenori, Hayashi, Hideki, Yamaguchi, Kanji, Iwaki, Michihiro, Yoneda, Masato, Shima, Toshihide, Fujii, Hideki, Morishita, Asahiro, Kawata, Kazuhito, Tomita, Kengo, Kawanaka, Miwa, Yoshida, Yuichi, Ikegami, Tadashi, Notsumata, Kazuo, Oeda, Satoshi, Atsukawa, Masanori, Kamada, Yoshihiro, Sumida, Yoshio, Fukushima, Hideaki, Miyoshi, Eiji, Aishima, Shinichi, Okanoue, Takeshi, Itoh, Yoshito, and Nakajima, Atsushi

Published
2024
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15. Epidemiology and Comparative Analysis of Outcomes of Intramedullary Spinal Cord Tumor Between Pediatric and Adult Patients

Author

Umebayashi, Daisuke, Naito, Kentaro, Kurokawa, Ryu, Endo, Toshiki, Mizuno, Masaki, Hoshimaru, Minoru, Kim, Phyo, Hida, Kazutoshi, Takami, Toshihiro, Hara, Masahito, Aoyama, Masahiro, Sugawara, Taku, Shimizu, Hiroaki, Ogihara, Kotaro, Sugawara, Atsushi, Itoki, Kazushige, Matsui, Seiji, Shigekawa, Seiji, Kunihiro, Noritsugu, Yamamoto, Shinji, Yasuhara, Takao, Iwasaki, Motoyuki, Ueda, Shigeo, Miyoshi, Yasuyuki, Hayashi, Hideki, Noriyuki, Nakayama, Iwama, Toru, Nakagawa, Hiroshi, Sumiyoshi, Manabu, Hijikata, Yasukazu, Uchikado, Hisaaki, Fukuda, Hitoshi, Nakai, Tomoaki, Sasayama, Takashi, Mishima, Kazuhiko, Inoue, Tomoo, Yano, Shunsuke, Sasamori, Toru, Mikuni, Nobuhiro, Akiyama, Yukinori, Hara, Tsuyoshi, Gondo, Gakuji, Yoshida, Mitsuhiro, Komatani, Hideki, Takahashi, Yuichi, Ito, Kiyoshi, Goto, Hisaharu, Yasuhiro, Node, Watanabe, Mizuki, Ito, Yasunobu, Hirano, Yoshitaka, Tominaga, Teiji, Takami, Hirokazu, Karakama, Jun, Ohashi, Hiroki, Harada, Naoyuki, Shingo, Tetsuro, Kawajiri, Satoshi, Yamauchi, Tomohiro, Uno, Tetsuji, Takai, Keisuke, Fujimoto, So, Otake, Yasufumi, Takeshima, Yasuhiro, Nakase, Hiroyuki, Saito, Akihiko, Morimoto, Daijiro, Kim, Kyongsong, Ohtonari, Tatsuya, Kageyama, Hiroto, Mitsuhara, Takafumi, Kuromi, Yosuke, Takahashi, Toshiyuki, Kanematsu, Ryo, Inoue, Tatsushi, Muto, Jun, Seki, Toshitaka, Yamazaki, Kazuyoshi, Koyanagi, Izumi, Yoshifuji, Kazuhisa, Fujimoto, Masashi, Nishikawa, Misao, Yagi, Takashi, Kinouchi, Hiroyuki, Murata, Hidetoshi, and Kitayama, Mari

Published
2024
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19. SWOT analysis of noninvasive tests for diagnosing NAFLD with severe fibrosis: an expert review by the JANIT Forum

Author

Kamada, Yoshihiro, Nakamura, Takahiro, Isobe, Satoko, Hosono, Kumiko, Suama, Yukiko, Ohtakaki, Yukie, Nauchi, Arihito, Yasuda, Naoto, Mitsuta, Soh, Miura, Kouichi, Yamamoto, Takuma, Hosono, Tatsunori, Yoshida, Akihiro, Kawanishi, Ippei, Fukushima, Hideaki, Kinoshita, Masao, Umeda, Atsushi, Kinoshita, Yuichi, Fukami, Kana, Miyawaki, Toshio, Fujii, Hideki, Yoshida, Yuichi, Kawanaka, Miwa, Hyogo, Hideyuki, Morishita, Asahiro, Hayashi, Hideki, Tobita, Hiroshi, Tomita, Kengo, Ikegami, Tadashi, Takahashi, Hirokazu, Yoneda, Masato, Jun, Dae Won, Sumida, Yoshio, Okanoue, Takeshi, and Nakajima, Atsushi

Published
2023
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22. Prediction of Liver-Related Events With a Combination of Liver Stiffness Measurements and Controlled Attenuation Parameters in Japanese Patients With Biopsy-Proven Non-alcoholic Fatty Liver Disease

Author

Hayashi, Hideki, Kamada, Yoshihiro, Fujii, Hideki, Takahashi, Hirokazu, Oeda, Satoshi, Iwaki, Michihiro, Kawaguchi, Takumi, Tomita, Eiichi, Yoneda, Masato, Tokushige, Akihiro, Ueda, Shinichiro, Aishima, Shinichi, Sumida, Yoshio, Nakajima, Atsushi, and Okanoue, Takeshi

Published
2023
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23. Evaluation of Kyoto's Event-Driven X-ray Astronomical SOI Pixel Sensor with a Large Imaging Area

Author

Hayashi, Hideki, Tsuru, Takeshi Go, Tanaka, Takaaki, Uchida, Hiroyuki, Matsumura, Hideaki, Tachibana, Katsuhiro, Harada, Sodai, Takeda, Ayaki, Mori, Koji, Nishioka, Yusuke, Takebayashi, Nobuaki, Yokoyama, Shoma, Fukuda, Kohei, Arai, Yasuo, Kurachi, Ikuo, Kawahito, Shoji, Kagawa, Keiichiro, Yasutomi, Keita, Shrestha, Sumeet, Nakanishi, Syunta, Kamehama, Hiroki, Kohmura, Takayoshi, Hagino, Kouichi, Negishi, Kousuke, Oono, Kenji, and Yarita, Keigo

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

We have been developing monolithic active pixel sensors, named ``XRPIX'', based on the silicon-on-insulator (SOI) pixel technology for future X-ray astronomy satellites. XRPIX has the function of event trigger and hit address outputs. This function allows us to read out analog signals only of hit pixels on trigger timing, which is referred to as the event-driven readout mode. Recently, we processed ``XRPIX5b'' with the largest imaging area of 21.9~mm $\times$ 13.8~mm in the XRPIX series. X-ray spectra are successfully obtained from all the pixels, and the readout noise is 46~e$^-$~(rms) in the frame readout mode. The gain variation was measured to be 1.2\%~(FWHM) among the pixels. We successfully obtain the X-ray image in the event-driven readout mode., Comment: 5 pages, 9 figures

Published
2019
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25. Epidemiology and Comparative Analysis of Outcomes of Intramedullary Spinal Cord Tumor Between Pediatric and Adult Patients

Author

Umebayashi, Daisuke, Naito, Kentaro, Kurokawa, Ryu, Endo, Toshiki, Mizuno, Masaki, Hoshimaru, Minoru, Kim, Phyo, Hida, Kazutoshi, Takami, Toshihiro, Hara, Masahito, Aoyama, Masahiro, Sugawara, Taku, Shimizu, Hiroaki, Ogihara, Kotaro, Sugawara, Atsushi, Itoki, Kazushige, Matsui, Seiji, Shigekawa, Seiji, Kunihiro, Noritsugu, Yamamoto, Shinji, Yasuhara, Takao, Iwasaki, Motoyuki, Ueda, Shigeo, Miyoshi, Yasuyuki, Hayashi, Hideki, Noriyuki, Nakayama, Iwama, Toru, Nakagawa, Hiroshi, Sumiyoshi, Manabu, Hijikata, Yasukazu, Uchikado, Hisaaki, Fukuda, Hitoshi, Nakai, Tomoaki, Sasayama, Takashi, Mishima, Kazuhiko, Inoue, Tomoo, Yano, Shunsuke, Sasamori, Toru, Mikuni, Nobuhiro, Akiyama, Yukinori, Hara, Tsuyoshi, Gondo, Gakuji, Yoshida, Mitsuhiro, Komatani, Hideki, Takahashi, Yuichi, Ito, Kiyoshi, Goto, Hisaharu, Yasuhiro, Node, Watanabe, Mizuki, Ito, Yasunobu, Hirano, Yoshitaka, Tominaga, Teiji, Takami, Hirokazu, Karakama, Jun, Ohashi, Hiroki, Harada, Naoyuki, Shingo, Tetsuro, Kawajiri, Satoshi, Yamauchi, Tomohiro, Uno, Tetsuji, Takai, Keisuke, Fujimoto, So, Otake, Yasufumi, Takeshima, Yasuhiro, Nakase, Hiroyuki, Saito, Akihiko, Morimoto, Daijiro, Kim, Kyongsong, Ohtonari, Tatsuya, Kageyama, Hiroto, Mitsuhara, Takafumi, Kuromi, Yosuke, Takahashi, Toshiyuki, Kanematsu, Ryo, Inoue, Tatsushi, Muto, Jun, Seki, Toshitaka, Yamazaki, Kazuyoshi, Koyanagi, Izumi, Yoshifuji, Kazuhisa, Fujimoto, Masashi, Nishikawa, Misao, Yagi, Takashi, Kinouchi, Hiroyuki, Murata, Hidetoshi, and Kitayama, Mari

Published
2023
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26. Clinical Outcomes in Biopsy-Proven Nonalcoholic Fatty Liver Disease Patients: A Multicenter Registry-based Cohort Study

Author

Fujii, Hideki, Iwaki, Michihiro, Hayashi, Hideki, Toyoda, Hidenori, Oeda, Satoshi, Hyogo, Hideyuki, Kawanaka, Miwa, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Yamamura, Sakura, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, Araki, Asuka, Arakaki, Shingo, Kawaguchi, Takumi, Noritake, Hidenao, Ono, Masafumi, Masaki, Tsutomu, Yasuda, Satoshi, Tomita, Eiichi, Yoneda, Masato, Kawada, Norifumi, Tokushige, Akihiro, Kamada, Yoshihiro, Takahashi, Hirokazu, Ueda, Shinichiro, Aishima, Shinichi, Sumida, Yoshio, Nakajima, Atsushi, and Okanoue, Takeshi

Published
2023
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27. Validation of Noninvasive Markers for HCC Risk Stratification in 1389 Patients With Biopsy-proven NAFLD

Author

Toyoda, Hidenori, Fujii, Hideki, Iwaki, Michihiro, Hayashi, Hideki, Oeda, Satoshi, Hyogo, Hideyuki, Kawanaka, Miwa, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Yamamura, Sakura, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, Araki, Asuka, Arakaki, Shingo, Kawaguchi, Takumi, Noritake, Hidenao, Ono, Masafumi, Masaki, Tsutomu, Yasuda, Satoshi, Tomita, Eiichi, Yoneda, Masato, Kawada, Norifumi, Tokushige, Akihiro, Kamada, Yoshihiro, Takahashi, Hirokazu, Ueda, Shinichiro, Aishima, Shinichi, Sumida, Yoshio, Nakajima, Atsushi, and Okanoue, Takeshi

Published
2023
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28. X-ray response evaluation in subpixel level for X-ray SOI pixel detectors

Author

Negishi, Kousuke, Kohmura, Takayoshi, Hagino, Kouichi, Kogiso, Taku, Oono, Kenji, Yarita, Keigo, Sasaki, Akinori, Tamasawa, Koki, Tsuru, Takeshi G., Tanaka, Takaaki, Matsumura, Hideaki, Tachibana, Katsuhiro, Hayashi, Hideki, Harada, Sodai, Mori, Koji, Takeda, Ayaki, Nishioka, Yusuke, Takebayashi, Nobuaki, Yokoyama, Shoma, Fukuda, Kohei, Arai, Yasuo, Miyoshi, Toshinobu, Kishimoto, Shunji, and Kurachi, Ikuo

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

We have been developing event-driven SOI Pixel Detectors, named `XRPIX' (X-Ray soiPIXel) based on the silicon-on-insulator (SOI) pixel technology, for the future X-ray astronomical satellite with wide band coverage from 0.5 keV to 40 keV. XRPIX has event trigger output function at each pixel to acquire a good time resolution of a few $\mu \rm s$ and has Correlated Double Sampling function to reduce electric noises. The good time resolution enables the XRPIX to reduce Non X-ray Background in the high energy band above 10\,keV drastically by using anti-coincidence technique with active shield counters surrounding XRPIX. In order to increase the soft X-ray sensitivity, it is necessary to make the dead layer on the X-ray incident surface as thin as possible. Since XRPIX1b, which is a device at the initial stage of development, is a front-illuminated (FI) type of XRPIX, low energy X-ray photons are absorbed in the 8 $\rm \mu$m thick circuit layer, lowering the sensitivity in the soft X-ray band. Therefore, we developed a back-illuminated (BI) device XRPIX2b, and confirmed high detection efficiency down to 2.6 keV, below which the efficiency is affected by the readout noise. In order to further improve the detection efficiency in the soft X-ray band, we developed a back-illuminated device XRPIX3b with lower readout noise. In this work, we irradiated 2--5 keV X-ray beam collimated to 4 $\rm \mu m \phi$ to the sensor layer side of the XRPIX3b at 6 $\rm \mu m$ pitch. In this paper, we reported the uniformity of the relative detection efficiency, gain and energy resolution in the subpixel level for the first time. We also confirmed that the variation in the relative detection efficiency at the subpixel level reported by Matsumura et al. has improved., Comment: 7 pages, 11 figures, 1 table, accepted for Nuclear Instruments and Methods in Physics Research Section A (NIMA)

Published
2018
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29. Proton Radiation Damage Experiment for X-Ray SOI Pixel Detectors

Author

Yarita, Keigo, Kohmura, Takayoshi, Hagino, Kouichi, Kogiso, Taku, Oono, Kenji, Negishi, Kousuke, Tamasawa, Koki, Sasaki, Akinori, Yoshiki, Satoshi, Tsuru, Takeshi Go, Tanaka, Takaaki, Matsumura, Hideaki, Tachibana, Katsuhiro, Hayashi, Hideki, Harada, Sodai, Takeda, Ayaki, Mori, Koji, Nishioka, Yusuke, Takebayashi, Nobuaki, Yokoyama, Shoma, Fukuda, Kohei, Arai, Yasuo, Miyoshi, Toshinobu, Kurachi, Ikuo, Hamano, Tsuyoshi, and group, the SOIPIX

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

In low earth orbit, there are many cosmic rays composed primarily of high energy protons. These cosmic rays cause surface and bulk radiation effects, resulting in degradation of detector performance. Quantitative evaluation of radiation hardness is essential in development of X-ray detectors for astronomical satellites. We performed proton irradiation experiments on newly developed X-ray detectors called XRPIX based on silicon-on-insulator technology at HIMAC in National Institute of Radiological Sciences. We irradiated 6 MeV protons with a total dose of 0.5 krad, equivalent to 6 years irradiation in orbit. As a result, the gain increases by 0.2% and the energy resolution degrades by 0.5%. Finally we irradiated protons up to 20 krad and found that detector performance degraded significantly at 5 krad. With 5 krad irradiation corresponding to 60 years in orbit, the gain increases by 0.7% and the energy resolution worsens by 10%. By decomposing into noise components, we found that the increase of the circuit noise is dominant in the degradation of the energy resolution., Comment: 6 pages, 11figures, accepted for Nuclear Instruments and Methods in Physics Research Section A (NIMA)

Published
2018
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30. Performance of the Silicon-On-Insulator Pixel Sensor for X-ray Astronomy, XRPIX6E, Equipped with Pinned Depleted Diode Structure

Author

Harada, Sodai, Tsuru, Takeshi Go, Tanaka, Takaaki, Uchida, Hiroyuki, Matsumura, Hideaki, Tachibana, Katsuhiro, Hayashi, Hideki, Takeda, Ayaki, Mori, Koji, Nishioka, Yusuke, Takebayashi, Nobuaki, Yokoyama, Shoma, Fukuda, Kohei, Arai, Yasuo, Kurachi, Ikuo, Kawahito, Shoji, Kagawa, Keiichiro, Yasutomi, Keita, Shrestha, Sumeet, Nakanishi, Syunta, Kamehama, Hiroki, Kohmura, Takayoshi, Hagino, Kouichi, Negishi, Kousuke, Oono, Kenji, and Yarita, Keigo

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We have been developing event driven X-ray Silicon-On-Insulator (SOI) pixel sensors, called "XRPIX", for the next generation of X-ray astronomy satellites. XRPIX is a monolithic active pixel sensor, fabricated using the SOI CMOS technology, and is equipped with the so-called "Event-Driven readout", which allows reading out only hit pixels by using the trigger circuit implemented in each pixel. The current version of XRPIX has lower spectral performance in the Event-Driven readout mode than in the Frame readout mode, which is due to the interference between the sensor layer and the circuit layer. The interference also lowers the gain. In order to suppress the interference, we developed a new device, "XRPIX6E" equipped with the Pinned Depleted Diode structure. A sufficiently highly-doped buried p-well is formed at the interface between the buried oxide layer and the sensor layer, and acts as a shield layer. XRPIX6E exhibits improved spectral performances both in the Event-Driven readout mode and in the Frame readout mode in comparison to previous devices. The energy resolutions in full width at half maximum at 6.4 keV are 236 $\pm$ 1 eV and 335 $\pm$ 4 eV in the Frame and Event-Driven readout modes, respectively. There are differences between the readout noise and the spectral performance in the two modes, which suggests that some mechanism still degrades the performance in the Event-Driven readout mode., Comment: 13 pages, 5 figures, 1 table, accepted for publication in NIMA on September 27, 2018

Published
2018
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31. Kyoto's Event-Driven X-ray Astronomy SOI pixel sensor for the FORCE mission

Author

Tsuru, Takeshi G., Hayashi, Hideki, Tachibana, Katsuhiro, Harada, Sodai, Uchida, Hiroyuki, Tanaka, Takaaki, Arai, Yasuo, Kurachi, Ikuo, Mori, Koji, Takeda, Ayaki, Nishioka, Yusuke, Takebayashi, Nobuaki, Yokoyama, Shoma, Fukuda, Kohei, Kohmura, Takayoshi, Hagino, Kouichi, Ohno, Kenji, Negishi, Kohsuke, Yarita, Keigo, Kawahito, Shoji, Kagawa, Keiichiro, Yasutomi, Keita, Shrestha, Sumeet, Nakanishi, Shunta, Kamehama, Hiroki, and Matsumura, Hideaki

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

We have been developing monolithic active pixel sensors, X-ray Astronomy SOI pixel sensors, XRPIXs, based on a Silicon-On-Insulator (SOI) CMOS technology as soft X-ray sensors for a future Japanese mission, FORCE (Focusing On Relativistic universe and Cosmic Evolution). The mission is characterized by broadband (1-80 keV) X-ray imaging spectroscopy with high angular resolution ($<15$~arcsec), with which we can achieve about ten times higher sensitivity in comparison to the previous missions above 10~keV. Immediate readout of only those pixels hit by an X-ray is available by an event trigger output function implemented in each pixel with the time resolution higher than $10~{\rm \mu sec}$ (Event-Driven readout mode). It allows us to do fast timing observation and also reduces non-X-ray background dominating at a high X-ray energy band above 5--10~keV by adopting an anti-coincidence technique. In this paper, we introduce our latest results from the developments of the XRPIXs. (1) We successfully developed a 3-side buttable back-side illumination device with an imaging area size of 21.9~mm$\times$13.8~mm and an pixel size of $36~{\rm \mu m} \times 36~{\rm \mu m}$. The X-ray throughput with the device reaches higher than 0.57~kHz in the Event-Driven readout mode. (2) We developed a device using the double SOI structure and found that the structure improves the spectral performance in the Event-Driven readout mode by suppressing the capacitive coupling interference between the sensor and circuit layers. (3) We also developed a new device equipped with the Pinned Depleted Diode structure and confirmed that the structure reduces the dark current generated at the interface region between the sensor and the SiO$_2$ insulator layers. The device shows an energy resolution of 216~eV in FWHM at 6.4~keV in the Event-Driven readout mode., Comment: 11 pages, 10 figures, Proceedings Volume 10709, High Energy, Optical, and Infrared Detectors for Astronomy VIII

Published
2018
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33. Validation study of age‐independent fibrosis score (Fibrosis‐3 index) in patients with metabolic dysfunction‐associated steatotic liver disease.

Author

Nouso, Kazuhiro, Kawanaka, Miwa, Fujii, Hideki, Kariyama, Kazuya, Toyoda, Hidenori, Iwaki, Michihiro, Hayashi, Hideki, Oeda, Satoshi, Hyogo, Hideyuki, Morishita, Asahiro, Munekage, Kensuke, Kawata, Kazuhito, Tsutsumi, Tsubasa, Sawada, Koji, Maeshiro, Tatsuji, Tobita, Hiroshi, Yoshida, Yuichi, Naito, Masafumi, Araki, Asuka, and Arakaki, Shingo

Subjects
HEPATIC fibrosis, RECEIVER operating characteristic curves, TREATMENT effectiveness, AGE groups, LIVER diseases
Abstract

Background and Aims: Because the accuracy of the Fibrosis‐4 (FIB‐4) index for predicting liver fibrosis changes with age, the need for different cut‐offs in various age groups has frequently been discussed. We developed the age‐independent score, the Fibrosis‐3 (FIB‐3) index, and have shown its usefulness in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD). This study aimed to validate the diagnostic ability of the FIB‐3 index to predict fibrosis progression using a large new patient cohort. Methods: The ability of the FIB‐3 index to predict liver fibrosis was analyzed by comparing it with that of the FIB‐4 index using data from 1398 patients with MASLD enrolled in the Asia‐based clinical outcome NAFLD study. Results: The areas under the receiver operating characteristic curves for predicting fibrosis stage F3 or higher were not different between the FIB‐3 and FIB‐4 indices in the entire cohort. Using the single ideal cut‐offs of the indices (3.41 for FIB‐3 index and 2.01 for FIB‐4 index), the predictive accuracy of the FIB‐3 index was not significantly different from that of the FIB‐4 index among patients aged <60 years; however, the accuracy of the FIB‐3 index was significantly higher than that of the FIB‐4 index in those aged ≥60 years (0.645 and 0.529, respectively; p < 0.0001). Conclusion: The high ability of the FIB‐3 index with a single cut‐off to predict liver fibrosis in patients with MASLD was confirmed. The FIB‐3 index could serve as a useful tool for assessing liver fibrosis regardless of age. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Pharmaceutical intervention for adverse events improves quality of life in patients with cancer undergoing outpatient chemotherapy

Author

Fujii, Hironori, Ueda, Yukino, Hirose, Chiemi, Ohata, Koichi, Sekiya, Kumiko, Kitahora, Mika, Sadaka, Shiori, Yamamoto, Senri, Watanabe, Daichi, Kato-Hayashi, Hiroko, Iihara, Hirotoshi, Kobayashi, Ryo, Kaburaki, Miho, Matsuhashi, Nobuhisa, Takahashi, Takao, Makiyama, Akitaka, Yoshida, Kazuhiro, Hayashi, Hideki, and Suzuki, Akio

Published
2022
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38. WED-273 The performance of the enhanced liver fibrosis test by cardiometabolic risk factors in patients with metabolic dysfunction-associated steatotic liver disease

Author

Kawata, Kazuhito, primary, Takahashi, Hirokazu, additional, Arai, Taeang, additional, Seko, Yuya, additional, Chida, Takeshi, additional, Noritake, Hiedenao, additional, Toyoda, Hidenori, additional, Hayashi, Hideki, additional, Yamaguchi, Kanji, additional, Iwaki, Michihiro, additional, Yoneda, Masato, additional, Shima, Toshihide, additional, Fujii, Hideki, additional, Morishita, Asahiro, additional, Tomita, Kengo, additional, Kawanaka, Miwa, additional, Yoshida, Yuichi, additional, Ikegami, Tadashi, additional, Notsumata, Kazuo, additional, Oeda, Satoshi, additional, Atsukawa, Masanori, additional, Kamada, Yoshihiro, additional, Sumida, Yoshio, additional, Fukushima, Hideaki, additional, Miyoshi, Eiji, additional, Aishima, Shinichi, additional, Okanoue, Takeshi, additional, Itoh, Yoshito, additional, and Nakajima, Atsushi, additional

Published
2024
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39. Evaluation of Steroid-Induced Osteoporosis Prevention Using Tracing Reports in Collaboration between Hospitals and Community Pharmacists

Author

Ishihara, Nonoko, primary, Yamashita, Shuji, additional, Seiki, Shizuno, additional, Tsutsui, Keito, additional, Kato-Hayashi, Hiroko, additional, Sakurai, Shuji, additional, Niwa, Kyoko, additional, Kawai, Takuyoshi, additional, Kai, Junko, additional, Suzuki, Akio, additional, and Hayashi, Hideki, additional

Published
2024
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40. Hepatic inflammation and fibrosis are profiles related to mid‐term mortality in biopsy‐proven MASLD: A multicenter study in Japan

Author

Tsutsumi, Tsubasa, primary, Kawaguchi, Takumi, additional, Fujii, Hideki, additional, Kamada, Yoshihiro, additional, Takahashi, Hirokazu, additional, Kawanaka, Miwa, additional, Sumida, Yoshio, additional, Iwaki, Michihiro, additional, Hayashi, Hideki, additional, Toyoda, Hidenori, additional, Oeda, Satoshi, additional, Hyogo, Hideyuki, additional, Morishita, Asahiro, additional, Munekage, Kensuke, additional, Kawata, Kazuhito, additional, Sawada, Koji, additional, Maeshiro, Tatsuji, additional, Tobita, Hiroshi, additional, Yoshida, Yuichi, additional, Naito, Masafumi, additional, Araki, Asuka, additional, Arakaki, Shingo, additional, Noritake, Hidenao, additional, Ono, Masafumi, additional, Masaki, Tsutomu, additional, Yasuda, Satoshi, additional, Tomita, Eiichi, additional, Yoneda, Masato, additional, Tokushige, Akihiro, additional, Ueda, Shinichiro, additional, Aishima, Shinichi, additional, Nakajima, Atsushi, additional, and Okanoue, Takeshi, additional

Published
2024
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42. A prospective, phase II trial of monotherapy with low-dose afatinib for patients with EGFR, mutation-positive, non-small cell lung cancer: Thoracic oncology research group 1632

Author

Noro, Rintaro, Igawa, Satoshi, Bessho, Akihiro, Hirose, Takashi, Shimokawa, Tsuneo, Nakashima, Masanao, Minato, Koichi, Seki, Nobuhiko, Tokito, Takaaki, Harada, Toshiyuki, Sasada, Shinji, Miyamoto, Shingo, Tanaka, Yosuke, Furuya, Naoki, Kaburagi, Takayuki, Hayashi, Hideki, Iihara, Hirotoshi, Okamoto, Hiroaki, and Kubota, Kaoru

Published
2021
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47. The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site.

Author

Kubo, Yoshinao, Hans, Manya Bakatumana, Nakamura, Taisuke, and Hayashi, Hideki

Subjects
MOUSE leukemia viruses, AMINO acid sequence, VIRAL envelopes, VIRUS diseases, PROTEINS, VIRAL envelope proteins
Abstract

Host restriction factor GBP2 suppresses the replication of the ecotropic Moloney murine leukemia virus (E-MLV) by inhibiting furin protease, which cleaves the viral envelope glycoprotein (Env) into surface (SU) and transmembrane (TM) subunits. We analyzed the impacts of GBP2 on the infection efficiency mediated by MLV Envs of different strains of ecotropic Moloney, polytropic Friend, amphotropic, and xenotropic MLV-related (XMRV) viruses. Interestingly, the Envs of ecotropic Moloney and polytropic Friend MLV were sensitive to the antiviral activity of GBP2, while XMRV and amphotropic Envs showed resistance. Consistent with the sensitivity to GBP2, the amino acid sequences of the sensitive Envs at the SU-TM cleavage site were similar, as were the sequences of the resistant Envs. SU-TM cleavage of the GBP2-sensitive Env protein was inhibited by furin silencing, whereas that of GBP2-resistant Env was not. The substitution of the ecotropic Moloney cleavage site sequence with that of XMRV conferred resistance to both GBP2 and furin silencing. Reciprocally, the substitution of the XMRV cleavage site sequence with that of the ecotropic sequence conferred sensitivity to GBP2 and furin silencing. According to the SU-TM cleavage site sequence, there were sensitive and resistant variants among ecotropic, polytropic, and xenotropic MLVs. This study found that the dependence of MLV Env proteins on furin cleavage and GBP2-mediated restriction is determined by the amino acid sequences at the SU-TM cleavage site. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Post-Transcriptional Induction of the Antiviral Host Factor GILT/IFI30 by Interferon Gamma.

Author

Nakamura, Taisuke, Izumida, Mai, Hans, Manya Bakatumana, Suzuki, Shuichi, Takahashi, Kensuke, Hayashi, Hideki, Ariyoshi, Koya, and Kubo, Yoshinao

Subjects
INTERFERON gamma, GENE expression, GENETIC translation, PROTEIN expression, MTOR inhibitors, INTERFERONS
Abstract

Gamma-interferon-inducible lysosomal thiol reductase (GILT) plays pivotal roles in both adaptive and innate immunities. GILT exhibits constitutive expression within antigen-presenting cells, whereas in other cell types, its expression is induced by interferon gamma (IFN-γ). Gaining insights into the precise molecular mechanism governing the induction of GILT protein by IFN-γ is of paramount importance for adaptive and innate immunities. In this study, we found that the 5′ segment of GILT mRNA inhibited GILT protein expression regardless of the presence of IFN-γ. Conversely, the 3′ segment of GILT mRNA suppressed GILT protein expression in the absence of IFN-γ, but it loses this inhibitory effect in its presence. Although the mTOR inhibitor rapamycin suppressed the induction of GILT protein expression by IFN-γ, the expression from luciferase sequence containing the 3′ segment of GILT mRNA was resistant to rapamycin in the presence of IFN-γ, but not in its absence. Collectively, this study elucidates the mechanism behind GILT induction by IFN-γ: in the absence of IFN-γ, GILT mRNA is constitutively transcribed, but the translation process is hindered by both the 5′ and 3′ segments. Upon exposure to IFN-γ, a translation inhibitor bound to the 3′ segment is liberated, and a translation activator interacts with the 3′ segment to trigger the initiation of GILT translation. [ABSTRACT FROM AUTHOR]

Published
2024
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