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303 results on '"Hayama M"'

1. P1.08C.05 The Clinicopathological and Prognostic Significance of Skip-N2 Metastases: A Retrospective Multicenter Study

Author

Suzawa, K., Ryuko, T., Shien, K., Okazaki, M., Ueno, T., Yamashita, M., Maki, Y., Fujiwara, T., Watanabe, M., Inokawa, H., Shikatani, Y., Misao, T., Washio, K., Torigoe, H., Hirami, Y., Tao, H., Hayama, M., Okutani, D., Otani, S., Sano, Y., Tomioka, Y., Muro, M., Uomoto, M., Kurosaki, T., Niman, E., Takahashi, K., Yaginuma, H., Kawamata, O., Yoshikawa, T., Ohtsuka, T., Nishkawa, H., Hayashi, D., Hayashi, T., and Toyooka, S.

Published
2024
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44. Helicobacter pylori infection produces expression of a secretory component in gastric mucous cells.

Author

Kaneko, Taimei, Ota, Hiroyoshi, Hayama, Masayoshi, Akamatsu, Taiji, Katsuyama, Tsutomu, Kaneko, T, Ota, H, Hayama, M, Akamatsu, T, and Katsuyama, T

Abstract

Helicobacter pylori infection induces the expression of a secretory component (SC) in gastric epithelial cells. We investigated the cell lineage of the SC- and immunoglobulin (Ig) A-expressing epithelial cells in H. pylori-infected gastric mucosa. Materials were obtained by means of gastric biopsy from H. pylori-infected patients (24 cases) before and after the eradication of H. pylori, from five normal uninfected volunteers, and from three gastrectomy cases. Acetic acid-ethanol-fixed and paraffin-embedded specimens were examined using histochemical staining for gastric mucins (periodic acid oxidation-thionine Schiff reaction-concanavalin A-horse radish peroxidase staining) by means of immunostaining for gastric mucins (45M1 and HIK1083), intestinal cells (MUC2 and CD10), Ki67, H. pylori, SC, and IgA. The SC and IgA were not found in normal gastric mucosa. The expressions of the SC and IgA in gastric surface mucous cells and mucous neck cells in the generating zone of the gastric mucosa of H. pylori-infected patients were significantly higher before eradication of H. pylori than after the eradication. These mucous cells have the potential for SC-mediated translocation of IgA into the gastric lumen, and this may act as part of the antibacterial defense system against H. pylori infection in the gastric generating zone. [ABSTRACT FROM AUTHOR]

Published
2000
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46. Helicobacter pylori infection produces reversible glycosylation changes to gastric mucins.

Author

Ota, Hiroyoshi, Nakayama, J., Momose, Masanobu, Hayama, Masayoshi, Akamatsu, Taiji, Katsuyama, Tsutomu, Graham, David Y., Genta, Robert M., Ota, H, Momose, M, Hayama, M, Akamatsu, T, Katsuyama, T, Graham, D Y, and Genta, R M

Abstract

The protective ability of gastric mucins may depend largely on their oligosaccharide chains. We evaluated the effects of H. pylori infection on the glycosylation of gastric mucins. Gastric biopsy specimens from 20 H. pylori-infected patients before and after cure of the H. pylori infection and 8 normal uninfected volunteers were examined by immunostaining for simple mucin-type glycoproteins and blood-group-related antigens bearing type 1 chain backbone. The immunoreactivity in different gastric compartments was evaluated. Simple mucin-type glycoproteins and blood-group-related antigens were expressed in surface mucous cells. Simple mucin-type glycoproteins showed antrum-predominant expression in normal volunteers and were found in significantly fewer surface mucous cells in infected patients than in normal volunteers; their expression was restored after eradication of H. pylori. Sialyl Lewis(a) and Lewis(b) were expressed in fewer surface mucous cells after than before eradication. The patterns of glycosylation of gastric mucins vary in different gastric compartments and are reversibly altered by H. pylori infection. These alterations may affect the protective functions of gastric mucins. [ABSTRACT FROM AUTHOR]

Published
1998
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47. ERCP features in 27 patients with autoimmune pancreatitis

Author

Horiuchi, A., Kawa, S., Hamano, H., Hayama, M., Ota, H., and Kiyosawa, K.

Abstract

Background: Autoimmune pancreatitis has been proposed as a new clinical entity. However, the ERCP features of this entity have not been well described. Methods: Clinical and radiographic features in 27 patients with a diagnosis of autoimmune pancreatitis were evaluated. Results: All 27 patients were at first suspected to have pancreatic cancer. The patients were predominantly elderly men and presented with jaundice or mild symptoms and pancreatic enlargement, but no attack of acute pancreatitis. A cholestatic biochemical profile and serum IgG elevation were usually present. A diffusely or segmentally irregular and narrow main pancreatic duct and a positive response to corticosteroid therapy were characteristic. During observation without treatment, serial pancreatography in 2 patients demonstrated progression of diffuse, irregular narrowing of the main pancreatic duct over periods, respectively, of 2 and 6 months. Both the irregular narrowing of the main pancreatic duct and distal bile duct strictures improved in various degrees in response to corticosteroid therapy. Conclusions: Segmental or diffuse irregular narrowing of the main pancreatic duct are ERCP features of autoimmune pancreatitis. (Gastrointest Endosc 2002;55:494-9.)

Published
2002
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50. Cell lineage specificity of newly raised monoclonal antibodies against gastric mucins in normal, metaplastic, and neoplastic human tissues and their application to pathology diagnosis.

Author

Ota, H, Hayama, M, Nakayama, J, Hidaka, H, Honda, T, Ishii, K, Fukushima, M, Uehara, T, Kurihara, M, Ishihara, K, Hotta, K, and Katsuyama, T

Abstract

The specificity of monoclonal antibodies against gastric mucins (designated as HIK1083, PGM 36, and PGM 37) was studied immunohistochemically in normal, metaplastic, and neoplastic human tissues. These antibodies labeled class III mucin-producing cells identified by paradoxical concanavalin A staining in normal stomach, duodenum (Brunner gland), biliary tract, and main pancreatic duct; in mucinous metaplasia of pancreas and gallbladder; and in adenocarcinomas of stomach (90%), bile duct (80%), gallbladder (100%), pancreas (80%), lung (100% of goblet cell type adenocarcinomas), ovary (67% of mucinous carcinomas), and uterine cervix (100% of adenoma malignum tumors). Normal and neoplastic cells of esophagus, colon, salivary gland, kidney, endometrium, breast, prostate, and liver, as well as normal small intestine, lung, and uterine cervix, were all negative. The antibodies used should be valuable for the detection of class III mucin and class III mucin-producing cells in normal, metaplastic, and neoplastic tissues.

Published
2001
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