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2. Application of a laparoscopic device for cell-derived sheet transplantation on the liver in a porcine model

Author

Toya, Keisuke, primary, Tomimaru, Yoshito, additional, Kobayashi, Shogo, additional, Nakajima, Kiyokazu, additional, Harada, Akima, additional, Sasaki, Kazuki, additional, Iwagami, Yoshifumi, additional, Yamada, Daisaku, additional, Noda, Takehiro, additional, Takahashi, Hidenori, additional, Hayakawa, Koichi, additional, Matsuda, Isamu, additional, Naka, Takahiro, additional, Miyagawa, Shigeru, additional, Doki, Yuichiro, additional, and Eguchi, Hidetoshi, additional

Published
2024
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4. The effect of different target temperatures in targeted temperature management on neurologically favorable outcome after out-of-hospital cardiac arrest: A nationwide multicenter observational study in Japan (the JAAM-OHCA registry)

Author

Irisawa, Taro, Matsuyama, Tasuku, Iwami, Taku, Yamada, Tomoki, Hayakawa, Koichi, Yoshiya, Kazuhisa, Noguchi, Kazuo, Nishimura, Tetsuro, Uejima, Toshifumi, Yagi, Yoshiki, Kiguchi, Takeyuki, Kishimoto, Masafumi, Matsuura, Makoto, Hayashi, Yasuyuki, Sogabe, Taku, Morooka, Takaya, Kitamura, Tetsuhisa, and Shimazu, Takeshi

Published
2018
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5. Predictive accuracy of biomarkers for survival among cardiac arrest patients with hypothermia: a prospective observational cohort study in Japan

Author

Okada, Yohei, Kiguchi, Takeyuki, Irisawa, Taro, Yoshiya, Kazuhisa, Yamada, Tomoki, Hayakawa, Koichi, Noguchi, Kazuo, Nishimura, Tetsuro, Ishibe, Takuya, Yagi, Yoshiki, Kishimoto, Masafumi, Shintani, Hiroshi, Hayashi, Yasuyuki, Sogabe, Taku, Morooka, Takaya, Sakamoto, Haruko, Suzuki, Keitaro, Nakamura, Fumiko, Nishioka, Norihiro, Matsuyama, Tasuku, Matsui, Satoshi, Shimazu, Takeshi, Koike, Kaoru, Kawamura, Takashi, Kitamura, Tetsuhisa, and Iwami, Taku

Published
2020
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6. Impact of Low-Flow Duration on Favorable Neurological Outcomes of Extracorporeal Cardiopulmonary Resuscitation After Out-of-Hospital Cardiac Arrest: A Multicenter Prospective Study

Author

Matsuyama, Tasuku, Irisawa, Taro, Yamada, Tomoki, Hayakawa, Koichi, Yoshiya, Kazuhisa, Noguchi, Kazuo, Nishimura, Tetsuro, Ishibe, Takuya, Yagi, Yoshiki, Kiguchi, Takeyuki, Kishimoto, Masafumi, Shintani, Hiroshi, Hayashi, Yasuyuki, Sogabe, Taku, Morooka, Takaya, Sakamoto, Haruko, Suzuki, Keitaro, Nakamura, Fumiko, Nishioka, Norihiro, Okada, Yohei, Matsui, Satoshi, Sado, Junya, Shimazu, Takeshi, Ohta, Bon, Iwami, Taku, and Kitamura, Tetsuhisa

Published
2020
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10. Man with bedsores.

Author

Shirahige, Hiroyuki, Aoki, Yoshihiro, Takahashi, Kensuke, Akao, Keiko, Hirabaru, Masataka, Akashi, Rina, Yoshino, Kentaro, Tachikawa, Atsuko, Sugawara, Daisuke, Tsukamoto, Yutaka, Atsumi, Tomoaki, Yamano, Shuhei, Morino, Shigeyuki, Nakano, Motoi, Hayakawa, Koichi, and Tasaki, Osamu

Published
2024
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12. Effectiveness of near-infrared spectroscopy-guided continuous chest compression resuscitation without rhythm check in patients with out-of-hospital cardiac arrest: The prospective multicenter TripleCPR 16 study

Author

Takegawa, Ryosuke, primary, Taniuchi, Satsuki, additional, Ohnishi, Mitsuo, additional, Muroya, Takashi, additional, Hayakawa, Koichi, additional, Tachino, Jotaro, additional, Hirose, Tomoya, additional, Nakao, Shunichiro, additional, Muratsu, Arisa, additional, Sakai, Tomohiko, additional, Hayashida, Kei, additional, Shintani, Ayumi, additional, Becker, Lance B., additional, Shimazu, Takeshi, additional, and Shiozaki, Tadahiko, additional

Published
2021
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13. Association between low pH and unfavorable neurological outcome among out-of-hospital cardiac arrest patients treated by extracorporeal CPR: a prospective observational cohort study in Japan

Author

Okada, Yohei, Kiguchi, Takeyuki, Irisawa, Taro, Yoshiya, Kazuhisa, Yamada, Tomoki, Hayakawa, Koichi, Noguchi, Kazuo, Nishimura, Tetsuro, Ishibe, Takuya, Yagi, Yoshiki, Kishimoto, Masafumi, Shintani, Hiroshi, Hayashi, Yasuyuki, Sogabe, Taku, Morooka, Takaya, Sakamoto, Haruko, Suzuki, Keitaro, Nakamura, Fumiko, Nishioka, Norihiro, Matsuyama, Tasuku, Sado, Junya, Matsui, Satoshi, Shimazu, Takeshi, Koike, Kaoru, Kawamura, Takashi, Kitamura, Tetsuhisa, Iwami, Taku, and the CRITICAL Study Group Investigators

Subjects
medicine.medical_specialty, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, Logistic regression, Extracorporeal, Extracorporeal life support, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Extracorporeal cardiopulmonary resuscitation, Ventricular fibrillation, business.industry, Research, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Blood gas assessment, 030208 emergency & critical care medicine, Odds ratio, lcsh:RC86-88.9, medicine.disease, Extracorporeal membrane oxygenation (ECMO), Confidence interval, Percutaneous cardiopulmonary support (PCPS), Observational study, business, Cohort study
Abstract

Okada, Y., Kiguchi, T., Irisawa, T. et al. Association between low pH and unfavorable neurological outcome among out-of-hospital cardiac arrest patients treated by extracorporeal CPR: a prospective observational cohort study in Japan. j intensive care 8, 34 (2020). https://doi.org/10.1186/s40560-020-00451-6, Background: We aimed to identify the association of pH value in blood gas assessment with neurological outcome among out-of-hospital cardiac arrest (OHCA) patients treated by extracorporeal cardiopulmonary resuscitation (ECPR). Methods: We retrospectively analyzed the database of a multicenter prospective observational study on OHCA patients in Osaka prefecture, Japan (CRITICAL study), from July 1, 2012 to December 31, 2016. We included adult OHCA patients treated by ECPR. Patients with OHCA from external causes such as trauma were excluded. We conducted logistic regression analysis to identify the odds ratio (OR) and 95% confidence interval (CI) of the pH value for 1 month favorable neurological outcome adjusted for potential confounders including sex, age, witnessed by bystander, CPR by bystander, pre-hospital initial cardiac rhythm, and cardiac rhythm on hospital arrival. Results: Among the 9822 patients in the database, 260 patients were finally included in the analysis. The three groups were Tertile 1: pH ≥ 7.030, Tertile 2: pH 6.875-7.029, and Tertile 3: pH < 6.875. The adjusted OR of Tertiles 2 and 3 compared with Tertile 1 for 1 month favorable neurological outcome were 0.26 (95% CI 0.10-0.63) and 0.24 (95% CI 0.09-0.61), respectively. Conclusions: This multi-institutional observational study showed that low pH value (< 7.03) before the implementation of ECPR was associated with 1 month unfavorable neurological outcome among OHCA patients treated with ECPR. It may be helpful to consider the candidate for ECPR.

Published
2020

14. Additional file 1 of Association between low pH and unfavorable neurological outcome among out-of-hospital cardiac arrest patients treated by extracorporeal CPR: a prospective observational cohort study in Japan

Author

Okada, Yohei, Kiguchi, Takeyuki, Irisawa, Taro, Yoshiya, Kazuhisa, Yamada, Tomoki, Hayakawa, Koichi, Noguchi, Kazuo, Nishimura, Tetsuro, Ishibe, Takuya, Yagi, Yoshiki, Kishimoto, Masafumi, Shintani, Hiroshi, Hayashi, Yasuyuki, Sogabe, Taku, Morooka, Takaya, Sakamoto, Haruko, Keitaro Suzuki, Nakamura, Fumiko, Nishioka, Norihiro, Matsuyama, Tasuku, Sado, Junya, Matsui, Satoshi, Shimazu, Takeshi, Koike, Kaoru, Kawamura, Takashi, Tetsuhisa Kitamura, and Iwami, Taku

Abstract

Additional file 1: S-Table 1. The characteristics of patients with missing BGA. S-Table 2. Original cohort (N=260). S-Table 3. Expected outcome among the excluded patients in the assumption (N=123). S-Table 4. The crude and adjusted ORs of other covariates. S-Table 5. The results of sensitivity analysis. S-Figure. Flow chart in sensitivity analysis.

Published
2020
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15. Additional file 1 of Predictive accuracy of biomarkers for survival among cardiac arrest patients with hypothermia: a prospective observational cohort study in Japan

Author

Okada, Yohei, Kiguchi, Takeyuki, Irisawa, Taro, Yoshiya, Kazuhisa, Yamada, Tomoki, Hayakawa, Koichi, Noguchi, Kazuo, Nishimura, Tetsuro, Ishibe, Takuya, Yagi, Yoshiki, Kishimoto, Masafumi, Shintani, Hiroshi, Hayashi, Yasuyuki, Sogabe, Taku, Morooka, Takaya, Sakamoto, Haruko, Keitaro Suzuki, Nakamura, Fumiko, Nishioka, Norihiro, Matsuyama, Tasuku, Matsui, Satoshi, Shimazu, Takeshi, Koike, Kaoru, Kawamura, Takashi, Tetsuhisa Kitamura, and Iwami, Taku

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2020
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17. Poor long-term survival of out-of-hospital cardiac arrest in children a multicenter, prospective registry in osaka, japan

Author

Matsui, Satoshi, 1000050270674, Sobue, Tomotaka, 1000050379202, Irisawa, Taro, 1000040623434, Yamada, Tomoki, 1000060403086, Hayakawa, Koichi, 1000040379201, Yoshiya, Kazuhisa, Noguchi, Kazuo, Nishimura, Tetsuro, Ishibe, Takuya, Yagi, Yoshiki, 1000030724380, Kiguchi, Takeyuki, Kishimoto, Masafumi, Shintani, Hiroshi, Hayashi, Yasuyuki, Sogabe, Taku, Morooka, Takaya, Sakamoto, Haruko, Suzuki, Keitaro, Nakamura, Fumiko, Nishioka, Norihiro, Okada, Yohei, 1000050829025, Matsuyama, Tasuku, Sado, Junya, 1000050196474, Shimazu, Takeshi, Tanaka, Ryojiro, Kurosawa, Hiroshi, 1000060437291, Iwami, Taku, 1000030639810, 0000-0003-0107-0580, Kitamura, Tetsuhisa, Matsui, Satoshi, 1000050270674, Sobue, Tomotaka, 1000050379202, Irisawa, Taro, 1000040623434, Yamada, Tomoki, 1000060403086, Hayakawa, Koichi, 1000040379201, Yoshiya, Kazuhisa, Noguchi, Kazuo, Nishimura, Tetsuro, Ishibe, Takuya, Yagi, Yoshiki, 1000030724380, Kiguchi, Takeyuki, Kishimoto, Masafumi, Shintani, Hiroshi, Hayashi, Yasuyuki, Sogabe, Taku, Morooka, Takaya, Sakamoto, Haruko, Suzuki, Keitaro, Nakamura, Fumiko, Nishioka, Norihiro, Okada, Yohei, 1000050829025, Matsuyama, Tasuku, Sado, Junya, 1000050196474, Shimazu, Takeshi, Tanaka, Ryojiro, Kurosawa, Hiroshi, 1000060437291, Iwami, Taku, 1000030639810, 0000-0003-0107-0580, and Kitamura, Tetsuhisa

Abstract

The effect of post-cardiac arrest care in children with out-of-hospital cardiac arrest (OHCA) has not been adequately established, and the long-term outcome after pediatric OHCA has not been sufficiently investigated. We describe here detailed in-hospital characteristics, actual management, and survival, including neurological status, 90 days after OHCA occurrence in children with OHCA transported to critical care medical centers (CCMCs). We analyzed the database of the Comprehensive Registry of Intensive Care for OHCA Survival (CRITI-CAL) study, which is a multicenter, prospective observational data registry designed to accumulate both pre-and in-hospital data on OHCA treatments. We enrolled all consecutive pediatric patients aged <18 years who had an OHCA and for whom resuscitation was attempted and who were transported to CCMCs between 2012 and 2016. A total of 263 pediatric patients with OHCA were enrolled. The average age of the patients was 6.3 years, 38.0% were aged < 1 year, and 60.8% were male. After hospital arrival, 4.9% of these pediatric patients re-ceived defibrillation; 1.9%, extracorporeal life support; 6.5%, target temperature management; and 88.2% adrenaline administration. The proportions of patients with 90-day survival and a pediatric cerebral performance category (PCPC) score of 1 or 2 were 6.1% and 1.9%, respectively. The proportion of patients with a PCPC score of 1 or 2 at 90 days after OHCA occurrence did not significantly improve during the study period. The proportion of pediatric patients with a 90-day PCPC score of 1 or 2 transported to CCMCs was ex-tremely low, and no significant improvements were observed during the study period.

Published
2020

22. Serum potassium level on hospital arrival and survival after out-of-hospital cardiac arrest: The CRITICAL study in Osaka, Japan

Author

Shida, Haruka, primary, Matsuyama, Tasuku, additional, Iwami, Taku, additional, Okabayashi, Satoe, additional, Yamada, Tomoki, additional, Hayakawa, Koichi, additional, Yoshiya, Kazuhisa, additional, Irisawa, Taro, additional, Noguchi, Kazuo, additional, Nishimura, Tetsuro, additional, Uejima, Toshifumi, additional, Yagi, Yoshiki, additional, Kiguchi, Takeyuki, additional, Kishimoto, Masafumi, additional, Matsuura, Makoto, additional, Hayashi, Yasuyuki, additional, Sogabe, Taku, additional, Morooka, Takaya, additional, Sado, Junya, additional, Kishimori, Takefumi, additional, Kiyohara, Kosuke, additional, Shimazu, Takeshi, additional, Kitamura, Tetsuhisa, additional, and Kawamura, Takashi, additional

Published
2020
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23. Predictive accuracy of biomarkers for survival among cardiac arrest patients with hypothermia: A prospective observational cohort study in Japan

Author

Okada, Yohei, primary, Kiguchi, Takeyuki, additional, Irisawa, Taro, additional, Yoshiya, Kazuhisa, additional, Yamada, Tomoki, additional, Hayakawa, Koichi, additional, Noguchi, Kazuo, additional, Nishimura, Tetsuro, additional, Ishibe, Takuya, additional, Yagi, Yoshiki, additional, Kishimoto, Masafumi, additional, Shintani, Hiroshi, additional, Hayashi, Yasuyuki, additional, Sogabe, Taku, additional, Morooka, Takaya, additional, Sakamoto, Haruko, additional, Suzuki, Keitaro, additional, Nakamura, Fumiko, additional, Nishioka, Norihiro, additional, Matsuyama, Tasuku, additional, Matsui, Satoshi, additional, Shimazu, Takeshi, additional, Koike, Kaoru, additional, Kawamura, Takashi, additional, Kitamura, Tetsuhisa, additional, and Iwami, Taku, additional

Published
2020
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25. Association between pH and neurological outcome among cardiac arrest patients treated by extracorporeal CPR: a prospective observational cohort study in Japan

Author

OKADA, YOHEI, primary, Kiguchi, Takeyuki, additional, Irisawa, Taro, additional, Yoshiya, Kazuhisa, additional, Yamada, Tomoki, additional, Hayakawa, Koichi, additional, Noguchi, Kazuo, additional, Nishimura, Tetsuro, additional, Ishibe, Takuya, additional, Yagi, Yoshiki, additional, Kishimoto, Masafumi, additional, Shintani, Hiroshi, additional, Hayashi, Yasuyuki, additional, Sogabe, Taku, additional, Morooka, Takaya, additional, Sakamoto, Haruko, additional, Suzuki, Keitaro, additional, Nakamura, Fumiko, additional, Nishioka, Norihiro, additional, Matsuyama, Tasuku, additional, Sado, Junya, additional, Matsui, Satoshi, additional, Shimazu, Takeshi, additional, Koike, Kaoru, additional, Kawamura, Takashi, additional, Kitamura, Tetsuhisa, additional, and Iwami, Taku, additional

Published
2020
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27. Intra-aortic balloon pump and survival with favorable neurological outcome after out-of-hospital cardiac arrest: A multicenter, prospective propensity score-matched study

Author

Kishimori, Takefumi, primary, Matsuyama, Tasuku, additional, Yamada, Tomoki, additional, Hayakawa, Koichi, additional, Yoshiya, Kazuhisa, additional, Irisawa, Taro, additional, Noguchi, Kazuo, additional, Nishimura, Tetsuro, additional, Uejima, Toshifumi, additional, Yagi, Yoshiki, additional, Kiguchi, Takeyuki, additional, Kishimoto, Masafumi, additional, Matsuura, Makoto, additional, Hayashi, Yasuyuki, additional, Sogabe, Taku, additional, Morooka, Takaya, additional, Sado, Junya, additional, Shida, Haruka, additional, Kiyohara, Kosuke, additional, Shimazu, Takeshi, additional, Kawamura, Takashi, additional, Iwami, Taku, additional, and Kitamura, Tetsuhisa, additional

Published
2019
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28. Home network file system for home network based on IEEE-1394 technology

Author

Igarashi, Tatsuya, Hayakawa, Koichi, Nishimura, Takuya, Ozawa, Takeshi, and Takizuka, Hiroshi

Subjects
Network architecture -- Analysis, Computer networks -- Models, Real-time data processing -- Methods, Business, Electronics and electrical industries, Engineering and manufacturing industries
Abstract

This paper proposes a network file system for home network based on IEEE-1394 technology. Home Network File System enables real-time playback, recording of audio/video file and file sharing for HAVi (Home Audio Video interoperability) compliant consumer devices.

Published
1999

31. Effect of Serum Albumin Concentration on Neurological Outcome After Out-of-Hospital Cardiac Arrest (from the CRITICAL [Comprehensive Registry of Intensive Cares for OHCA Survival] Study in Osaka, Japan)

Author

Matsuyama, Tasuku, primary, Iwami, Taku, additional, Yamada, Tomoki, additional, Hayakawa, Koichi, additional, Yoshiya, Kazuhisa, additional, Irisawa, Taro, additional, Abe, Yoshio, additional, Nishimura, Tetsuro, additional, Uejima, Toshifumi, additional, Ohishi, Yasuo, additional, Kiguchi, Takeyuki, additional, Kishi, Masashi, additional, Kishimoto, Masafumi, additional, Nakao, Shota, additional, Hayashi, Yasuyuki, additional, Sogabe, Taku, additional, Morooka, Takaya, additional, Izawa, Junichi, additional, Shimamoto, Tomonari, additional, Hatakeyama, Toshihiro, additional, Fujii, Tomoko, additional, Sado, Junya, additional, Shimazu, Takeshi, additional, Kawamura, Takashi, additional, and Kitamura, Tetsuhisa, additional

Published
2018
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33. Relationship between Intracranial Pressure or Cerebral Perfusion Pressure and Prognosis in Patients with Severe Traumatic Brain Injury Treated with Mild Hypothermia

Author

Hayakawa, Koichi, primary, Tasaki, Osamu, additional, Iwamura, Hiromu, additional, Wada, Daiki, additional, Saitou, Fukuki, additional, Iba, Jiro, additional, Yoshiya, Kazuhisa, additional, Ikegawa, Hitoshi, additional, Shiozaki, Tadahiko, additional, Nakamori, Yasushi, additional, Fujimi, Satoshi, additional, Shimazu, Takeshi, additional, and Kuwagata, Yasuyuki, additional

Published
2017
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34. Impact of age on survival of patients with out‐of‐hospital cardiac arrest transported to tertiary emergency medical institutions in Osaka, Japan.

Author

Nakamura, Fumiko, Kajino, Kentaro, Kitamura, Tetsuhisa, Daya, Mohamud R, Ong, Marcus EH, Matsuyama, Tasuku, Yamada, Tomoki, Hayakawa, Koichi, Irisawa, Taro, Yoshiya, Kazuhisa, Noguchi, Kazuo, Nishimura, Tetsuro, Uejima, Toshifumi, Yagi, Yoshiki, Kiguchi, Takeyuki, Kishimoto, Masafumi, Matsuura, Makoto, Hayashi, Yasuyuki, Sogabe, Taku, and Morooka, Takaya

Subjects
AGE distribution, CARDIAC arrest, CONFIDENCE intervals, HOSPITAL emergency services, LONGITUDINAL method, MULTIVARIATE analysis, SCIENTIFIC observation, SURVIVAL, TERTIARY care, ODDS ratio
Abstract

Aim: The purpose of this study was to evaluate the out‐of‐hospital cardiac arrest (OHCA) characteristics of patients stratified by age who had resuscitation attempted and were transported to tertiary emergency medical institutions in Osaka Prefecture, Japan; especially those of advanced age. Methods: A prospective, population‐based, observational review was carried out of consecutive OHCA patients with emergency responder resuscitation attempts from July 2012 to December 2016 in Osaka, Japan. Patients were classified into four groups: (i) 18–64 years; (ii) 65–74 years; (iii) 75–84 years; and (iv) ≥85 years. Patient, event and treatment characteristics were examined for patients with presumed cardiac etiology of OHCA. The primary outcome was the 1‐month survival with a neurologically favorable outcome. Results: A total of 4636 patients with OHCA of presumed cardiac origin were transported to tertiary emergency medical institutions. The number of patients in the four groups was as follows: (i) 1290 (27.8%); (ii) 1102 (23.8%); (iii) 1420 (30.6%); and (iv) 824 (17.8%). The 1‐month survival with a neurologically favorable outcome was: (i) 207 (16.0%); (ii) 96 (8.7%); (iii) 60 (4.2%); and (iv) seven (0.85%). In a multivariate analysis for 1‐month survival with a neurologically favorable outcome, increased age was a significant prognostic factor (≥85 years; adjusted odds ratio 0.08, 95% confidence interval 0.03–0.23) for poor outcomes. Conclusions: In this population, advanced age (≥85 years) was strongly associated with poor outcomes. Further discussion of policies directed at resuscitation of very elderly OHCA patients is required, considering limited medical resources and the rapidly aging population in Japan. Geriatr Gerontol Int 2019; 19: 1088–1095. [ABSTRACT FROM AUTHOR]

Published
2019
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35. Rationale, design, and profile of Comprehensive Registry of In-Hospital Intensive Care for OHCA Survival (CRITICAL) study in Osaka, Japan

Author

1000040623434, Yamada, Tomoki, 1000030639810, Kitamura, Tetsuhisa, 1000060403086, Hayakawa, Koichi, 1000040379201, Yoshiya, Kazuhisa, 1000050379202, Irisawa, Taro, Abe, Yoshio, Ishiro, Megumi, Uejima, Toshifumi, Ohishi, Yasuo, Kaneda, Kazuhisa, 1000030724380, Kiguchi, Takeyuki, Kishi, Masashi, Kishimoto, Masafumi, Nakao, Shota, Nishimura, Tetsuro, Hayashi, Yasuyuki, Morooka, Takaya, Izawa, Junichi, 1000010828411, Shimamoto, Tomonari, Hatakeyama, Toshihiro, 1000050829025, Matsuyama, Tasuku, 1000010252230, Kawamura, Takashi, 1000050196474, Shimazu, Takeshi, 1000060437291, Iwami, Taku, 1000040623434, Yamada, Tomoki, 1000030639810, Kitamura, Tetsuhisa, 1000060403086, Hayakawa, Koichi, 1000040379201, Yoshiya, Kazuhisa, 1000050379202, Irisawa, Taro, Abe, Yoshio, Ishiro, Megumi, Uejima, Toshifumi, Ohishi, Yasuo, Kaneda, Kazuhisa, 1000030724380, Kiguchi, Takeyuki, Kishi, Masashi, Kishimoto, Masafumi, Nakao, Shota, Nishimura, Tetsuro, Hayashi, Yasuyuki, Morooka, Takaya, Izawa, Junichi, 1000010828411, Shimamoto, Tomonari, Hatakeyama, Toshihiro, 1000050829025, Matsuyama, Tasuku, 1000010252230, Kawamura, Takashi, 1000050196474, Shimazu, Takeshi, 1000060437291, and Iwami, Taku

Abstract

Yamada, T., Kitamura, T., Hayakawa, K. et al. Rationale, design, and profile of Comprehensive Registry of In-Hospital Intensive Care for OHCA Survival (CRITICAL) study in Osaka, Japan. j intensive care 4, 10 (2016). https://doi.org/10.1186/s40560-016-0128-5, Background: We established a multi-center, prospective cohort that could provide appropriate therapeutic strategies such as criteria for the introduction and the effectiveness of in-hospital advanced treatments, including percutaneous coronary intervention (PCI), target temperature management, and extracorporeal cardiopulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) patients. Methods: In Osaka Prefecture, Japan, we registered all consecutive patients who were suffering from an OHCA for whom resuscitation was attempted and who were then transported to institutions participating in this registry since July 1, 2012. A total of 11 critical care medical centers and one hospital with an emergency care department participated in this registry. The primary outcome was neurological status after OHCA, defined as cerebral performance category (CPC) scale. Results: A total of 688 OHCA patients were documented between July 2012 and December 2012. Of them, 657 were eligible for our analysis. Patients' average age was 66.2 years old, and male patients accounted for 66.2 %. The proportion of OHCAs having a cardiac origin was 50.4 %. The proportion as first documented rhythm of ventricular fibrillation/pulseless ventricular tachycardia was 11.6 %, pulseless electrical activity 23.4 %, and asystole 54.5 %. After hospital arrival, 10.5 % received defibrillation, 90.8 % tracheal intubation, 3.0 % ECPR, 3.5 % PCI, and 83.1 % adrenaline administration. The proportions of 90-day survival and CPC 1/2 at 90 days after OHCAs were 5.9 and 3.0 %, respectively. Conclusions: The Comprehensive Registry of In-hospital Intensive Care for OHCA Survival (CRITICAL) study will enroll over 2000 OHCA patients every year. It is still ongoing without a set termination date in order to provide valuable information regarding appropriate therapeutic strategies for OHCA patients (UMIN000007528).

Published
2016

38. Vasodilating prostaglandin E1 does not reproduce interleukin‐1β‐induced oxygen metabolism abnormalities in rabbits

Author

Matsuyama, Shigenari, Hayakawa, Koichi, Sakuramoto, Kazuhito, Muroya, Takashi, Nakamori, Yasushi, Ikegawa, Hitoshi, Shimazu, Takeshi, and Kuwagata, Yasuyuki

Subjects
Original Articles
Abstract

We have reported that administration of recombinant human interleukin (IL)-1β induced circulatory shock in rabbits by causing overproduction of vasodilating prostaglandin(s) and simultaneously impaired oxygen metabolism by causing an abnormal dependence of oxygen consumption (VOSixteen rabbits were assigned to one of three groups and given a single injection of 10 μg/kg IL-1β (IL-1β group,Both IL-1β and PGEThese results indicate that simple vasodilation and hypotension induced by administration of PGE

Published
2014

39. Ventricular septal perforation after blunt chest trauma due to blows from a fist

Author

Muratsu, Arisa, primary, Muroya, Takashi, additional, Onoe, Atsunori, additional, Nakamura, Fumiko, additional, Wada, Daiki, additional, Nakajima, Mari, additional, Iwamura, Hiromu, additional, Kishimoto, Masanobu, additional, Yui, Rintaro, additional, Sakuramoto, Kazuhito, additional, Hayakawa, Koichi, additional, Saito, Fukuki, additional, Nakamori, Yasushi, additional, and Kuwagata, Yasuyuki, additional

Published
2016
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40. Rationale, design, and profile of Comprehensive Registry of In-Hospital Intensive Care for OHCA Survival (CRITICAL) study in Osaka, Japan

Author

Yamada, Tomoki, primary, Kitamura, Tetsuhisa, additional, Hayakawa, Koichi, additional, Yoshiya, Kazuhisa, additional, Irisawa, Taro, additional, Abe, Yoshio, additional, Ishiro, Megumi, additional, Uejima, Toshifumi, additional, Ohishi, Yasuo, additional, Kaneda, Kazuhisa, additional, Kiguchi, Takeyuki, additional, Kishi, Masashi, additional, Kishimoto, Masafumi, additional, Nakao, Shota, additional, Nishimura, Tetsuro, additional, Hayashi, Yasuyuki, additional, Morooka, Takaya, additional, Izawa, Junichi, additional, Shimamoto, Tomonari, additional, Hatakeyama, Toshihiro, additional, Matsuyama, Tasuku, additional, Kawamura, Takashi, additional, Shimazu, Takeshi, additional, and Iwami, Taku, additional

Published
2016
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41. Prognostic Impact of Serum Albumin Concentration for Neurologically Favorable Outcome in Patients Treated with Targeted Temperature Management After Out-of-Hospital Cardiac Arrest: A Multicenter Prospective Study.

Author

Matsuyama, Tasuku, Iwami, Taku, Yamada, Tomoki, Hayakawa, Koichi, Yoshiya, Kazuhisa, Irisawa, Taro, Abe, Yoshio, Nishimura, Tetsuro, Uejima, Toshifumi, Ohishi, Yasuo, Kiguchi, Takeyuki, Kishi, Masashi, Kishimoto, Masafumi, Nakao, Shota, Hayashi, Yasuyuki, Sogabe, Taku, Morooka, Takaya, Izawa, Junichi, Shimamoto, Tomonari, and Hatakeyama, Toshihiro

Published
2018
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44. Inhibition of the ATP-dependent interaction of actin and myosin by the catalytic domain of the myosin light chain kinase of smooth muscle: possible involvement in smooth muscle relaxation

Author

Koichi Samizo, Tsuyoshi Okagaki, Hayakawa Koichi, and Kazuhiro Kohama

Subjects
Myofilament, Meromyosin, Myosin light-chain kinase, Chemistry, Muscle Relaxation, Muscle, Smooth, macromolecular substances, General Medicine, Smooth muscle contraction, Myosins, Biochemistry, Tropomyosin, Actins, Myosin head, Adenosine Triphosphate, Myosin, Biophysics, Animals, Phosphorylation, Myofibril, Molecular Biology, Myosin-Light-Chain Kinase
Abstract

Myosin light chain kinase (MLCK) phosphorylates the light chain of smooth muscle myosin enabling its interaction with actin. This interaction initiates smooth muscle contraction. MLCK has another role that is not attributable to its phosphorylating activity, i.e., it inhibits the ATP-dependent movement of actin filaments on a glass surface coated with phosphorylated myosin. To analyze the inhibitory effect of MLCK, the catalytic domain of MLCK was obtained with or without the regulatory sequence adjacent to the C-terminal of the domain, and the inhibitory effect of the domain was examined by the movement of actin filaments. All the domains work so as to inhibit actin filament movement whether or not the regulatory sequence is included. When the domain includes the regulatory sequence, calmodulin in the presence of calcium abolishes the inhibition. Since the phosphorylation reaction is not involved in regulating the movement by MLCK, and a catalytic fragment that shows no kinase activity also inhibits movement, the kinase activity is not related to inhibition. Higher concentrations of MLCK inhibit the binding of actin filaments to myosin-coated surfaces as well as their movement. We discuss the dual roles of the domain, the phosphorylation of myosin that allows myosin to cross-bridge with actin and a novel function that breaks cross-bridging.

Published
1999

45. Outcome prediction model for severe traumatic brain injury

Author

Iba, Jiro, primary, Tasaki, Osamu, additional, Hirao, Tomohito, additional, Mohri, Tomoyoshi, additional, Yoshiya, Kazuhisa, additional, Hayakawa, Koichi, additional, Shiozaki, Tadahiko, additional, Hamasaki, Toshimitsu, additional, Nakamori, Yasushi, additional, Fujimi, Satoshi, additional, Ogura, Hiroshi, additional, Kuwagata, Yasuyuki, additional, and Shimazu, Takeshi, additional

Published
2013
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46. Toxic epidermal necrolysis complicated by sepsis, haemophagocytic syndrome, and severe liver dysfunction associated with elevated interleukin-10 production

Author

Yamaoka, Toshifumi, additional, Azukizawa, Hiroaki, additional, Tanemura, Atsushi, additional, Murota, Hiroyuki, additional, Hirose, Tomoya, additional, Hayakawa, Koichi, additional, Shimazu, Takeshi, additional, Wada, Naoki, additional, Morii, Eiichi, additional, and Katayama, Ichiro, additional

Published
2012
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