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27 results on '"Hayakawa, Katsura"'

1. The Restrictive Red Blood Cell Transfusion Strategy for Critically Injured Patients (RESTRIC) trial: a cluster-randomized, crossover, non-inferiority multicenter trial of restrictive transfusion in trauma

Author

Hayakawa, Mineji, Tagami, Takashi, Kudo, Daisuke, Ono, Kota, Aoki, Makoto, Endo, Akira, Yumoto, Tetsuya, Matsumura, Yosuke, Irino, Shiho, Sekine, Kazuhiko, Ushio, Noritaka, Ogura, Takayuki, Nachi, Sho, Irie, Yuhei, Hayakawa, Katsura, Ito, Yusuke, Okishio, Yuko, Muronoi, Tomohiro, Kosaki, Yoshinori, Ito, Kaori, Nakatsutsumi, Keita, Kondo, Yutaka, Ueda, Taichiro, Fukuma, Hiroshi, Saisaka, Yuichi, Tominaga, Naoki, Kurita, Takeo, Nakayama, Fumihiko, Shibata, Tomotaka, and Kushimoto, Shigeki

Published
2023
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3. Relationship between critical care nutrition and post-intensive care syndrome in surviving ventilated patients with COVID-19: a multicenter prospective observational study

Author

Nakamura, Kensuke, primary, Hatakeyama, Junji, additional, Liu, Keibun, additional, Yamakawa, Kazuma, additional, Nishida, Takeshi, additional, Ohshimo, Shinichiro, additional, Inoue, Shigeaki, additional, Hashimoto, Satoru, additional, Maruyama, Shuhei, additional, Kawakami, Daisuke, additional, Ogata, Yoshitaka, additional, Hayakawa, Katsura, additional, Shimizu, Hiroaki, additional, Oshima, Taku, additional, Fuchigami, Tatsuya, additional, and Nishida, Osamu, additional

Published
2024
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4. Development and validation of the predictive risk of death model for adult patients admitted to intensive care units in Japan: an approach to improve the accuracy of healthcare quality measures

Author

Endo, Hideki, Uchino, Shigehiko, Hashimoto, Satoru, Aoki, Yoshitaka, Hashiba, Eiji, Hatakeyama, Junji, Hayakawa, Katsura, Ichihara, Nao, Irie, Hiromasa, Kawasaki, Tatsuya, Kumasawa, Junji, Kurosawa, Hiroshi, Nakamura, Tomoyuki, Ohbe, Hiroyuki, Okamoto, Hiroshi, Shigemitsu, Hidenobu, Tagami, Takashi, Takaki, Shunsuke, Takimoto, Kohei, Uchida, Masatoshi, and Miyata, Hiroaki

Published
2021
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5. Conventional risk prediction models fail to accurately predict mortality risk among patients with coronavirus disease 2019 in intensive care units: a difficult time to assess clinical severity and quality of care

Author

Endo, Hideki, Ohbe, Hiroyuki, Kumasawa, Junji, Uchino, Shigehiko, Hashimoto, Satoru, Aoki, Yoshitaka, Asaga, Takehiko, Hashiba, Eiji, Hatakeyama, Junji, Hayakawa, Katsura, Ichihara, Nao, Irie, Hiromasa, Kawasaki, Tatsuya, Kurosawa, Hiroshi, Nakamura, Tomoyuki, Okamoto, Hiroshi, Shigemitsu, Hidenobu, Takaki, Shunsuke, Takimoto, Kohei, Uchida, Masatoshi, Uchimido, Ryo, and Miyata, Hiroaki

Published
2021
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7. Prevalence and Risk Factor Analysis of Post-Intensive Care Syndrome in Patients with COVID-19 Requiring Mechanical Ventilation: A Multicenter Prospective Observational Study

Author

Hatakeyama, Junji, primary, Inoue, Shigeaki, additional, Liu, Keibun, additional, Yamakawa, Kazuma, additional, Nishida, Takeshi, additional, Ohshimo, Shinichiro, additional, Hashimoto, Satoru, additional, Kanda, Naoki, additional, Maruyama, Shuhei, additional, Ogata, Yoshitaka, additional, Kawakami, Daisuke, additional, Shimizu, Hiroaki, additional, Hayakawa, Katsura, additional, Tanaka, Aiko, additional, Oshima, Taku, additional, Fuchigami, Tatsuya, additional, Yawata, Hironori, additional, Oe, Kyoji, additional, Kawauchi, Akira, additional, Yamagata, Hidehiro, additional, Harada, Masahiro, additional, Sato, Yuichi, additional, Nakamura, Tomoyuki, additional, Sugiki, Kei, additional, Hakozaki, Takahiro, additional, Beppu, Satoru, additional, Anraku, Masaki, additional, Kato, Noboru, additional, Iwashita, Tomomi, additional, Kamijo, Hiroshi, additional, Kitagawa, Yuichiro, additional, Nagashima, Michio, additional, Nishimaki, Hirona, additional, Tokuda, Kentaro, additional, Nishida, Osamu, additional, and Nakamura, Kensuke, additional

Published
2022
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8. Relation between nutrition therapy in the acute phase and outcomes of ventilated patients with COVID-19 infection: a multicenter prospective observational study

Author

Nakamura, Kensuke, primary, Hatakeyama, Junji, additional, Liu, Keibun, additional, Kanda, Naoki, additional, Yamakawa, Kazuma, additional, Nishida, Takeshi, additional, Ohshimo, Shinichiro, additional, Inoue, Shigeaki, additional, Hashimoto, Satoru, additional, Maruyama, Shuhei, additional, Kawakami, Daisuke, additional, Ogata, Yoshitaka, additional, Hayakawa, Katsura, additional, Shimizu, Hiroaki, additional, Oshima, Taku, additional, Fuchigami, Tatsuya, additional, and Nishida, Osamu, additional

Published
2022
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9. Two Cases of Intrafamilial Transmission of Community-Acquired Methicillin-Resistant Staphylococcus aureus Producing Both PVL and TSST-1 Causing Fatal Necrotizing Pneumonia and Sepsis

Author

Hayakawa, Katsura, Yamaguchi, Tetsuo, Ono, Daisuke, Suzuki, Hajime, Kamiyama, Jiro, Taguchi, Shigemasa, and Kiyota, Kazuya

Subjects
Infection and Drug Resistance, CA-MRSA, toxic shock syndrome toxin 1, community-acquired methicillin-resistant Staphylococcus aureus, necrotizing pneumonia, Case Series, PVL, Panton–Valentine leukocidin, biochemical phenomena, metabolism, and nutrition, TSST-1, bacterial infections and mycoses
Abstract

Katsura Hayakawa,1 Tetsuo Yamaguchi,2 Daisuke Ono,2 Hajime Suzuki,1 Jiro Kamiyama,1 Shigemasa Taguchi,1 Kazuya Kiyota1 1Department of Emergency and Critical Care Medicine, Saitama Red Cross Hospital, Saitama, Japan; 2Department of Microbiology and Infection Diseases, Toho University School of Medicine, Tokyo, JapanCorrespondence: Katsura Hayakawa Department of Emergency and Critical Care Medicine, Saitama Red Cross Hospital, 1-5 Shintoshin, Chu-o-Ku, Saitama City 330-8553, JapanTel +81-48-852-1111Fax +81-48-852-3120Email gene1982jp@gmail.comIntroduction: Staphylococcus aureus produces numerous toxins, such as toxic shock syndrome toxin 1 (TSST-1) and Panton–Valentine leukocidin (PVL). We isolated community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) strains producing both TSST-1 and PVL isolated from severe necrotizing pneumonia cases in a Nepali family. Detection of these CA-MRSA strains is rare in the world, and infection with these strains can take a rapidly progressive and lethal course. In this study, we traced the clinical course of this case and conducted a genetic analysis of the isolated strains.Case Report: We described 2 familial cases (a 20-year-old male and 61-year-old female) of severe necrotizing pneumonia caused by CA-MRSA with the TSST-1 and PVL genes. A 20-year-old Nepalese male was admitted to our hospital after a 3-day history of high fever and coughing. Despite resuscitation efforts, he died of multiple organ failure. A 61-year-old Nepalese female was admitted to our hospital with a complaint of high fever and dyspnea for 1 day. She was the grandmother of the male subject and mostly stayed at his residence in Japan. We administered intravenous antibiotics, including anti-MRSA antibiotics, and she improved in 2 weeks. The sequence type of the isolates was ST22/SCCmec type IVa, and the spa type was t005. The virulence genes detected were as follows: PVL gene (lukSF-pv), TSST-1 gene (tst-1), sec, seg, sei, sel, sem, sen, seo, and seu. ST22 was not the dominant CA-MRSA clone type in Japan. Some of the reports demonstrated that PVL-/TSST-1-positive ST22-MRSA strains are prevalent in Nepal. Therefore, the MRSA strains were thought to be acquired from Nepal.Conclusion: These cases highlight the emergence of TSST-1- and PVL-positive CA-MRSA infection and its association with life-threatening community-acquired necrotizing pneumonia. Clinicians should note the possibility of introducing MRSA strains from abroad and be aware of this illness to initiate appropriate treatment.Keywords: community-acquired methicillin-resistant Staphylococcus aureus, CA-MRSA, toxic shock syndrome toxin 1, TSST-1, Panton–Valentine leukocidin, PVL, necrotizing pneumonia

Published
2020

10. Additional file 1 of Development and validation of the predictive risk of death model for adult patients admitted to intensive care units in Japan: an approach to improve the accuracy of healthcare quality measures

Author

Endo, Hideki, Shigehiko Uchino, Hashimoto, Satoru, Aoki, Yoshitaka, Hashiba, Eiji, Hatakeyama, Junji, Hayakawa, Katsura, Ichihara, Nao, Irie, Hiromasa, Kawasaki, Tatsuya, Kumasawa, Junji, Kurosawa, Hiroshi, Nakamura, Tomoyuki, Ohbe, Hiroyuki, Okamoto, Hiroshi, Hidenobu Shigemitsu, Tagami, Takashi, Takaki, Shunsuke, Takimoto, Kohei, Uchida, Masatoshi, and Miyata, Hiroaki

Abstract

Additional file 1: Table S1 Coefficients of models 1 and 2. R code for fitting models 1, 2, and 3. Fig. S1 EWMA charts for the 44 ICUs (recalibrated with the method used in model 3). Sequential admissions are presented on the x-axis. The red lines show the exponentially weighted moving average of mortality, with starting points of the average mortality in each ICU during the study period and with a weight of 0.005 on the latest data. The light and dark green lines are the control limits representing two- and three-standard deviations, respectively. EWMA, exponentially weighted moving average; ICU, intensive care unit

Published
2021
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11. Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study

Author

Bus, Liesbet De, Depuydt, Pieter, Steen, Johan, Dhaese, Sofie, Smet, Ken De, Tabah, Alexis, Akova, Murat, Cotta, Menino Osbert, Pascale, Gennaro De, Dimopoulos, George, Fujitani, Shigeki, Garnacho-Montero, Jose, Leone, Marc, Lipman, Jeffrey, Ostermann, Marlies, Paiva, José-Artur, Schouten, Jeroen, Sjövall, Fredrik, Timsit, Jean-François, Roberts, Jason A., Zahar, Jean-Ralph, Zand, Farid, Zirpe, Kapil, Waele, Jan J. De, Rios, Fernando, Vazquez, Alejandro Risso, Vidal, Maria Gabriela, Zakalik, Graciela, Attokaran, Antony George, Banakh, Iouri, Dey-Chatterjee, Smita, Ewan, Julie, Ferrier, Janet, Forbes, Loretta, Fourie, Cheryl, Leditschke, Anne, Murray, Lauren, Eller, Philipp, Biston, Patrick, Bracke, Stephanie, Crop, Luc De, Schryver, Nicolas De, Frans, Eric, Spapen, Herbert, Malderen, Claire Van, Vansteelandt, Stijn, Vermeiren, Daisy, Arévalo, Elias Pablo, Crespo, Mónica, Flores, Roberto Zelaya, Píza, Petr, Tutillo, Diego Morocho, Elme, Andreas, Kallaste, Anne, Starkopf, Joel, Bourenne, Jeremy, Calypso, Mathieu, Cohen, Yves, Dahyot-Fizelier, Claire, Depret, François, Guillot, Max, Imzi, Nadia, Jochmans, Sebastien, Kouatchet, Achille, Lepape, Alain, Martin, Olivier, Heim, Markus, Schaller, Stefan J, Arvaniti, Kostoula, Bekridelis, Anestis, Ioannidis, Panagiotis, Mitrakos, Cornelia, Papanikolaou, Metaxia N., Pouriki, Sofia, Vemvetsou, Anna, Abraham, Babu, Bhattacharya, Pradip Kumar, Budugu, Anusha, Dixit, Subhal, Gurav, Sushma, Kandanuri, Padmaja, Prabhu, Dattatray Arun, Rathod, Darshana, Savaru, Kavitha, Udupa, Ashwin Neelavar, Varghese, Sunitha Binu, Bakhodaei, Hossein Haddad, Dabiri, Gholamreza, Fallahi, Mohammad Javad, Feiz, Farnia, Firoozifar, Mohammad, Khaloo, Vahid, Maghsudi, Behzad, Masjedi, Mansoor, Nikandish, Reza, Sabetian, Golnar, Marsh, Brian, Martin-Loeches, Ignacio, Steiner, Jan, Barbagallo, Maria, Caricato, Anselmo, Cortegiani, Andrea, D’Andrea, Rocco, Deana, Cristian, Donati, Abele, Girardis, Massimo, Mandalà, Giuliana, Panarello, Giovanna, Pasero, Daniela, Pelagalli, Lorella, Soave, Paolo Maurizio, Spadaro, Savino, Fujita, Yoshihito, Fujiwara, Shinsuke, Hara, Yuya, Hashi, Hideki, Hashimoto, Satoru, Hashimoto, Hideki, Hayakawa, Katsura, Inoue, Masash, Isokawa, Shutaro, Kameda, Shinya, Kamohara, Hidenobu, Kanamoto, Masafumi, Katayama, Shinshu, Kawagishi, Toshiomi, Kawano, Yasumasa, Kida, Yoshiko, Kita, Mami, Kobayashi, Atsuko, Kuriyama, Akira, Naito, Takaki, Nashiki, Hiroshi, Nishiyama, Kei, Shindo, Shunsuke, Suzuki, Taketo, Takaba, Akihiro, Tanaka, Chie, Tetsuya, Komuro, Tomioka, Yoshihiro, Yanagawa, Youichi, Yoshida, Hideki, Adnan, Syamhanin, Hasan, Mohd Shahnaz, Sulaiman, Helmi, Lopez, Gilberto A. Gasca, Hernández-Cárdenas, Carmen M., Ñamendys-Silva, Silvio A., Bethlehem, Carina, Lange, Dylan de, Hunfeld, Nicole, Numan, Sandra, Leeuwen, Henk van, Owens, Daniel, Almeida, Mónica, Fragoso, Elsa, Leonor, Tiago, Pereira, José-Manuel, Filipescu, Daniela, Grigoras, Ioana, Popescu, Mihai, Tomescu, Dana, Alshahrani, Mohammed S., Alvarez-Gonzalez, Manuel, Barrero-García, Irene, Blasco-Navalpotro, Miguel Angel, Claverias, Laura, Estella, Ángel, Espina, Lorena Forcelledo, Garmendia, Jose Luis Garcia, Prieto, Emilio García, Gómez-Prieto, Gracia, Conde, Carlos Jiménez, Sagasti, Fernando Martinez, Cantero, Alicia Muñoz, Orejas-Gallego, Alberto, Papiol, Elisabeth, Pérez-Civantos, Demetrio, Laderas, Juan Carlos Pozo, Álvarez, Josep Trenado, Vera-Artázcoz, Paula, Cortés, Pablo Vidal, Oldner, Anders, Spångfors, Martin, Alp, Emine, Köksal, Iftihar, Korten, Volkan, Özveren, Arife, Hall, Anna, Hatton, Kevin W., Laudanski, Krzysztof, other, and, Bus, Liesbet De, Depuydt, Pieter, Steen, Johan, Dhaese, Sofie, Smet, Ken De, Tabah, Alexis, Akova, Murat, Cotta, Menino Osbert, Pascale, Gennaro De, Dimopoulos, George, Fujitani, Shigeki, Garnacho-Montero, Jose, Leone, Marc, Lipman, Jeffrey, Ostermann, Marlies, Paiva, José-Artur, Schouten, Jeroen, Sjövall, Fredrik, Timsit, Jean-François, Roberts, Jason A., Zahar, Jean-Ralph, Zand, Farid, Zirpe, Kapil, Waele, Jan J. De, Rios, Fernando, Vazquez, Alejandro Risso, Vidal, Maria Gabriela, Zakalik, Graciela, Attokaran, Antony George, Banakh, Iouri, Dey-Chatterjee, Smita, Ewan, Julie, Ferrier, Janet, Forbes, Loretta, Fourie, Cheryl, Leditschke, Anne, Murray, Lauren, Eller, Philipp, Biston, Patrick, Bracke, Stephanie, Crop, Luc De, Schryver, Nicolas De, Frans, Eric, Spapen, Herbert, Malderen, Claire Van, Vansteelandt, Stijn, Vermeiren, Daisy, Arévalo, Elias Pablo, Crespo, Mónica, Flores, Roberto Zelaya, Píza, Petr, Tutillo, Diego Morocho, Elme, Andreas, Kallaste, Anne, Starkopf, Joel, Bourenne, Jeremy, Calypso, Mathieu, Cohen, Yves, Dahyot-Fizelier, Claire, Depret, François, Guillot, Max, Imzi, Nadia, Jochmans, Sebastien, Kouatchet, Achille, Lepape, Alain, Martin, Olivier, Heim, Markus, Schaller, Stefan J, Arvaniti, Kostoula, Bekridelis, Anestis, Ioannidis, Panagiotis, Mitrakos, Cornelia, Papanikolaou, Metaxia N., Pouriki, Sofia, Vemvetsou, Anna, Abraham, Babu, Bhattacharya, Pradip Kumar, Budugu, Anusha, Dixit, Subhal, Gurav, Sushma, Kandanuri, Padmaja, Prabhu, Dattatray Arun, Rathod, Darshana, Savaru, Kavitha, Udupa, Ashwin Neelavar, Varghese, Sunitha Binu, Bakhodaei, Hossein Haddad, Dabiri, Gholamreza, Fallahi, Mohammad Javad, Feiz, Farnia, Firoozifar, Mohammad, Khaloo, Vahid, Maghsudi, Behzad, Masjedi, Mansoor, Nikandish, Reza, Sabetian, Golnar, Marsh, Brian, Martin-Loeches, Ignacio, Steiner, Jan, Barbagallo, Maria, Caricato, Anselmo, Cortegiani, Andrea, D’Andrea, Rocco, Deana, Cristian, Donati, Abele, Girardis, Massimo, Mandalà, Giuliana, Panarello, Giovanna, Pasero, Daniela, Pelagalli, Lorella, Soave, Paolo Maurizio, Spadaro, Savino, Fujita, Yoshihito, Fujiwara, Shinsuke, Hara, Yuya, Hashi, Hideki, Hashimoto, Satoru, Hashimoto, Hideki, Hayakawa, Katsura, Inoue, Masash, Isokawa, Shutaro, Kameda, Shinya, Kamohara, Hidenobu, Kanamoto, Masafumi, Katayama, Shinshu, Kawagishi, Toshiomi, Kawano, Yasumasa, Kida, Yoshiko, Kita, Mami, Kobayashi, Atsuko, Kuriyama, Akira, Naito, Takaki, Nashiki, Hiroshi, Nishiyama, Kei, Shindo, Shunsuke, Suzuki, Taketo, Takaba, Akihiro, Tanaka, Chie, Tetsuya, Komuro, Tomioka, Yoshihiro, Yanagawa, Youichi, Yoshida, Hideki, Adnan, Syamhanin, Hasan, Mohd Shahnaz, Sulaiman, Helmi, Lopez, Gilberto A. Gasca, Hernández-Cárdenas, Carmen M., Ñamendys-Silva, Silvio A., Bethlehem, Carina, Lange, Dylan de, Hunfeld, Nicole, Numan, Sandra, Leeuwen, Henk van, Owens, Daniel, Almeida, Mónica, Fragoso, Elsa, Leonor, Tiago, Pereira, José-Manuel, Filipescu, Daniela, Grigoras, Ioana, Popescu, Mihai, Tomescu, Dana, Alshahrani, Mohammed S., Alvarez-Gonzalez, Manuel, Barrero-García, Irene, Blasco-Navalpotro, Miguel Angel, Claverias, Laura, Estella, Ángel, Espina, Lorena Forcelledo, Garmendia, Jose Luis Garcia, Prieto, Emilio García, Gómez-Prieto, Gracia, Conde, Carlos Jiménez, Sagasti, Fernando Martinez, Cantero, Alicia Muñoz, Orejas-Gallego, Alberto, Papiol, Elisabeth, Pérez-Civantos, Demetrio, Laderas, Juan Carlos Pozo, Álvarez, Josep Trenado, Vera-Artázcoz, Paula, Cortés, Pablo Vidal, Oldner, Anders, Spångfors, Martin, Alp, Emine, Köksal, Iftihar, Korten, Volkan, Özveren, Arife, Hall, Anna, Hatton, Kevin W., Laudanski, Krzysztof, and other, and

Abstract

Purpose: The DIANA study aimed to evaluate how often antimicrobial de-escalation (ADE) of empirical treatment is performed in the intensive care unit (ICU) and to estimate the effect of ADE on clinical cure on day 7 following treatment initiation. Methods: Adult ICU patients receiving empirical antimicrobial therapy for bacterial infection were studied in a prospective observational study from October 2016 until May 2018. ADE was defined as (1) discontinuation of an antimicrobial in case of empirical combination therapy or (2) replacement of an antimicrobial with the intention to narrow the antimicrobial spectrum, within the first 3 days of therapy. Inverse probability (IP) weighting was used to account for time-varying confounding when estimating the effect of ADE on clinical cure. Results: Overall, 1495 patients from 152 ICUs in 28 countries were studied. Combination therapy was prescribed in 50%, and carbapenems were prescribed in 26% of patients. Empirical therapy underwent ADE, no change and change other than ADE within the first 3 days in 16%, 63% and 22%, respectively. Unadjusted mortality at day 28 was 15.8% in the ADE cohort and 19.4% in patients with no change [p = 0.27; RR 0.83 (95% CI 0.60–1.14)]. The IP-weighted relative risk estimate for clinical cure comparing ADE with no-ADE patients (no change or change other than ADE) was 1.37 (95% CI 1.14–1.64). Conclusion: ADE was infrequently applied in critically ill-infected patients. The observational effect estimate on clinical cure suggested no deleterious impact of ADE compared to no-ADE. However, residual confounding is likely.

Published
2020

12. Two Cases of Intrafamilial Transmission of Community-Acquired Methicillin-Resistant Staphylococcus aureus Producing Both PVL and TSST-1 Causing Fatal Necrotizing Pneumonia and Sepsis

Author

Hayakawa,Katsura, Yamaguchi,Tetsuo, Ono,Daisuke, Suzuki,Hajime, Kamiyama,Jiro, Taguchi,Shigemasa, Kiyota,Kazuya, Hayakawa,Katsura, Yamaguchi,Tetsuo, Ono,Daisuke, Suzuki,Hajime, Kamiyama,Jiro, Taguchi,Shigemasa, and Kiyota,Kazuya

Abstract

Katsura Hayakawa,1 Tetsuo Yamaguchi,2 Daisuke Ono,2 Hajime Suzuki,1 Jiro Kamiyama,1 Shigemasa Taguchi,1 Kazuya Kiyota1 1Department of Emergency and Critical Care Medicine, Saitama Red Cross Hospital, Saitama, Japan; 2Department of Microbiology and Infection Diseases, Toho University School of Medicine, Tokyo, JapanCorrespondence: Katsura Hayakawa Department of Emergency and Critical Care Medicine, Saitama Red Cross Hospital, 1-5 Shintoshin, Chu-o-Ku, Saitama City 330-8553, JapanTel +81-48-852-1111Fax +81-48-852-3120Email gene1982jp@gmail.comIntroduction: Staphylococcus aureus produces numerous toxins, such as toxic shock syndrome toxin 1 (TSST-1) and Panton–Valentine leukocidin (PVL). We isolated community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) strains producing both TSST-1 and PVL isolated from severe necrotizing pneumonia cases in a Nepali family. Detection of these CA-MRSA strains is rare in the world, and infection with these strains can take a rapidly progressive and lethal course. In this study, we traced the clinical course of this case and conducted a genetic analysis of the isolated strains.Case Report: We described 2 familial cases (a 20-year-old male and 61-year-old female) of severe necrotizing pneumonia caused by CA-MRSA with the TSST-1 and PVL genes. A 20-year-old Nepalese male was admitted to our hospital after a 3-day history of high fever and coughing. Despite resuscitation efforts, he died of multiple organ failure. A 61-year-old Nepalese female was admitted to our hospital with a complaint of high fever and dyspnea for 1 day. She was the grandmother of the male subject and mostly stayed at his residence in Japan. We administered intravenous antibiotics, including anti-MRSA antibiotics, and she improved in 2 weeks. The sequence type of the isolates was ST22/SCCmec type IVa, and the spa type was t005. The virulence genes detected were as follows: PVL gene (lukSF-pv), TSST-1 gene (tst-1), sec, seg, sei, sel, sem, sen

Published
2020

13. Can Brain Natriuretic Peptide Be Used as an Indicator of Over-infusion in Patients with Acute Sepsis? : A Pilot Study Evaluating Correlation Between Brain Natriuretic Peptide and Global End-diastolic Volume Index

Author

Kishihara, Yuki, primary, Yasuda, Hideto, additional, Morisawa, Kenichiro, additional, Fujitani, Shigeki, additional, Homma, Yosuke, additional, Shigemitsu, Kazuaki, additional, Saito, Nobuyuki, additional, Hayakawa, Katsura, additional, Hifumi, Toru, additional, Rinka, Hiroshi, additional, Mayumi, Toshihiko, additional, Fujiwara, Shinsuke, additional, Murao, Yoshinori, additional, and Taira, Yasuhiko, additional

Published
2020
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14. Can the global end‐diastolic volume index guide fluid management in septic patients? A multicenter randomized controlled trial

Author

Morisawa, Kenichiro, primary, Fujitani, Shigeki, additional, Homma, Yosuke, additional, Shigemitsu, Kazuaki, additional, Saito, Nobuyuki, additional, Hayakawa, Katsura, additional, Yasuda, Hideto, additional, Hifumi, Toru, additional, Rinka, Hiroshi, additional, Mayumi, Toshihiko, additional, Fujiwara, Shinsuke, additional, Murao, Yoshinori, additional, and Taira, Yasuhiko, additional

Published
2019
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15. Additional file 1: Table S1. of Characteristics, treatments, and outcomes of severe sepsis of 3195 ICU-treated adult patients throughout Japan during 2011â 2013

Author

Mineji Hayakawa, Shinjiro Saito, Shigehiko Uchino, Yamakawa, Kazuma, Kudo, Daisuke, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, Mayumi, Toshihiko, Azuhata, Takeo, Ito, Fumihito, Shodai Yoshihiro, Hayakawa, Katsura, Nakashima, Tsuyoshi, Ogura, Takayuki, Noda, Eiichiro, Nakamura, Yoshihiko, Sekine, Ryosuke, Yoshikawa, Yoshiaki, Sekino, Motohiro, Ueno, Keiko, Okuda, Yuko, Watanabe, Masayuki, Tampo, Akihito, Saito, Nobuyuki, Kitai, Yuya, Takahashi, Hiroki, Kobayashi, Iwao, Kondo, Yutaka, Matsunaga, Wataru, Nachi, Sho, Miike, Toru, Takahashi, Hiroshi, Takauji, Shuhei, Umakoshi, Kensuke, Todaka, Takafumi, Kodaira, Hiroshi, Kohkichi Andoh, Kasai, Takehiko, Iwashita, Yoshiaki, Arai, Hideaki, Murata, Masato, Yamane, Masahiro, Shiga, Kazuhiro, and Hori, Naoto

Abstract

Epidemiological information from previous reports after 2005. (DOC 48 kb)

Published
2016
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16. Low-dose immunoglobulin G is not associated with mortality in patients with sepsis and septic shock

Author

Iizuka, Yusuke, primary, Sanui, Masamitsu, additional, Sasabuchi, Yusuke, additional, Lefor, Alan Kawarai, additional, Hayakawa, Mineji, additional, Saito, Shinjiro, additional, Uchino, Shigehiko, additional, Yamakawa, Kazuma, additional, Kudo, Daisuke, additional, Takimoto, Kohei, additional, Mayumi, Toshihiko, additional, Azuhata, Takeo, additional, Ito, Fumihito, additional, Yoshihiro, Shodai, additional, Hayakawa, Katsura, additional, Nakashima, Tsuyoshi, additional, Ogura, Takayuki, additional, Noda, Eiichiro, additional, Nakamura, Yoshihiko, additional, Sekine, Ryosuke, additional, Yoshikawa, Yoshiaki, additional, Sekino, Motohiro, additional, Ueno, Keiko, additional, Okuda, Yuko, additional, Watanabe, Masayuki, additional, Tampo, Akihito, additional, Saito, Nobuyuki, additional, Kitai, Yuya, additional, Takahashi, Hiroki, additional, Kobayashi, Iwao, additional, Kondo, Yutaka, additional, Matsunaga, Wataru, additional, Nachi, Sho, additional, Miike, Toru, additional, Takahashi, Hiroshi, additional, Takauji, Shuhei, additional, Umakoshi, Kensuke, additional, Todaka, Takafumi, additional, Kodaira, Hiroshi, additional, Andoh, Kohkichi, additional, Kasai, Takehiko, additional, Iwashita, Yoshiaki, additional, Arai, Hideaki, additional, Murata, Masato, additional, Yamane, Masahiro, additional, Shiga, Kazuhiro, additional, and Hori, Naoto, additional

Published
2017
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17. Antithrombin Supplementation and Mortality in Sepsis-Induced Disseminated Intravascular Coagulation

Author

Hayakawa, Mineji, primary, Kudo, Daisuke, additional, Saito, Shinjiro, additional, Uchino, Shigehiko, additional, Yamakawa, Kazuma, additional, Iizuka, Yusuke, additional, Sanui, Masamitsu, additional, Takimoto, Kohei, additional, Mayumi, Toshihiko, additional, Ono, Kota, additional, Azuhata, Takeo, additional, Ito, Fumihito, additional, Yoshihiro, Shodai, additional, Hayakawa, Katsura, additional, Nakashima, Tsuyoshi, additional, Ogura, Takayuki, additional, Noda, Eiichiro, additional, Nakamura, Yoshihiko, additional, Sekine, Ryosuke, additional, Yoshikawa, Yoshiaki, additional, Sekino, Motohiro, additional, Ueno, Keiko, additional, Okuda, Yuko, additional, Watanabe, Masayuki, additional, Tampo, Akihito, additional, Saito, Nobuyuki, additional, Kitai, Yuya, additional, Takahashi, Hiroki, additional, Kobayashi, Iwao, additional, Kondo, Yutaka, additional, Matsunaga, Wataru, additional, Nachi, Sho, additional, Miike, Toru, additional, Takahashi, Hiroshi, additional, Takauji, Shuhei, additional, Umakoshi, Kensuke, additional, Todaka, Takafumi, additional, Kodaira, Hiroshi, additional, Andoh, Kohkichi, additional, Kasai, Takehiko, additional, Iwashita, Yoshiaki, additional, Arai, Hideaki, additional, Murata, Masato, additional, Yamane, Masahiro, additional, Shiga, Kazuhiro, additional, and Hori, Naoto, additional

Published
2016
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18. Antithrombin Supplementation and Mortality in Sepsis-Induced Disseminated Intravascular Coagulation : A Multicenter Retrospective Observational Study

Author

Hayakawa, Mineji, Kudo, Daisuke, Saito, Shinjiro, Uchino, Shigehiko, Yamakawa, Kazuma, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, Mayumi, Toshihiko, Ono, Kota, Azuhata, Takeo, Ito, Fumihito, Yoshihiro, Shodai, Hayakawa, Katsura, Nakashima, Tsuyoshi, Ogura, Takayuki, Noda, Eiichiro, Nakamura, Yoshihiko, Sekine, Ryosuke, Yoshikawa, Yoshiaki, Sekino, Motohiro, Ueno, Keiko, Okuda, Yuko, Watanabe, Masayuki, Tampo, Akihito, Saito, Nobuyuki, Kitai, Yuya, Takahashi, Hiroki, Kobayashi, Iwao, Kondo, Yutaka, Matsunaga, Wataru, Nachi, Sho, Miike, Toru, Takahashi, Hiroshi, Takauji, Shuhei, Umakoshi, Kensuke, Todaka, Takafumi, Kodaira, Hiroshi, Andoh, Kohkichi, Kasai, Takehiko, Iwashita, Yoshiaki, Arai, Hideaki, Murata, Masato, Yamane, Masahiro, Shiga, Kazuhiro, Hori, Naoto, Hayakawa, Mineji, Kudo, Daisuke, Saito, Shinjiro, Uchino, Shigehiko, Yamakawa, Kazuma, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, Mayumi, Toshihiko, Ono, Kota, Azuhata, Takeo, Ito, Fumihito, Yoshihiro, Shodai, Hayakawa, Katsura, Nakashima, Tsuyoshi, Ogura, Takayuki, Noda, Eiichiro, Nakamura, Yoshihiko, Sekine, Ryosuke, Yoshikawa, Yoshiaki, Sekino, Motohiro, Ueno, Keiko, Okuda, Yuko, Watanabe, Masayuki, Tampo, Akihito, Saito, Nobuyuki, Kitai, Yuya, Takahashi, Hiroki, Kobayashi, Iwao, Kondo, Yutaka, Matsunaga, Wataru, Nachi, Sho, Miike, Toru, Takahashi, Hiroshi, Takauji, Shuhei, Umakoshi, Kensuke, Todaka, Takafumi, Kodaira, Hiroshi, Andoh, Kohkichi, Kasai, Takehiko, Iwashita, Yoshiaki, Arai, Hideaki, Murata, Masato, Yamane, Masahiro, Shiga, Kazuhiro, and Hori, Naoto

Abstract

Supplemental doses of antithrombin (AT) are widely used to treat sepsis-induced disseminated intravascular coagulation (DIC) in Japan. However, evidence on the benefits of AT supplementation for DIC is insufficient. This multicenter retrospective observational study aimed to clarify the effect of AT supplementation on sepsis-induced DIC using propensity score analyses. Data from 3,195 consecutive adult patients admitted to 42 intensive care units for severe sepsis treatment were retrospectively analyzed; 1,784 patients were diagnosed with DIC (n=715, AT group; n=1,069, control group). Inverse probability of treatment-weighted propensity score analysis indicated a statistically significant association between AT supplementation and lower in-hospital all-cause mortality (n=1,784, odds ratio [95% confidence intervals]: 0.748 [0.572-0.978], P=0.034). However, quintile-stratified propensity score analysis (n=1,784, odds ratio: 0.823 [0.646-1.050], P=0.117) and propensity score matching analysis (461 matching pairs, odds ratio: 0.855 [0.649-1.125], P=0.263) did not show this association. In the early days after intensive care unit admission, the survival rate was statistically higher in the propensity score-matched AT group than in the propensity score-matched control group (P=0.007). In DIC patients without concomitant heparin administration, similar results were observed. In conclusion, AT supplementation may be associated with reduced in-hospital all-cause mortality in patients with sepsis-induced DIC. However, the statistical robustness of this connection was not strong. In addition, although the number of transfusions needed in patients with AT supplementation increased, severe bleeding complications did not.

Published
2016

19. Characteristics, treatments, and outcomes of severe sepsis of 3195 ICU-treated adult patients throughout Japan during 2011-2013

Author

Hayakawa, Mineji, Saito, Shinjiro, Uchino, Shigehiko, Yamakawa, Kazuma, Kudo, Daisuke, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, Mayumi, Toshihiko, Azuhata, Takeo, Ito, Fumihito, Yoshihiro, Shodai, Hayakawa, Katsura, Nakashima, Tsuyoshi, Ogura, Takayuki, Noda, Eiichiro, Nakamura, Yoshihiko, Sekine, Ryosuke, Yoshikawa, Yoshiaki, Sekino, Motohiro, Ueno, Keiko, Okuda, Yuko, Watanabe, Masayuki, Tampo, Akihito, Saito, Nobuyuki, Kitai, Yuya, Takahashi, Hiroki, Kobayashi, Iwao, Kondo, Yutaka, Matsunaga, Wataru, Nachi, Sho, Miike, Toru, Takahashi, Hiroshi, Takauji, Shuhei, Umakoshi, Kensuke, Todaka, Takafumi, Kodaira, Hiroshi, Andoh, Kohkichi, Kasai, Takehiko, Iwashita, Yoshiaki, Arai, Hideaki, Murata, Masato, Yamane, Masahiro, Shiga, Kazuhiro, Hori, Naoto, Hayakawa, Mineji, Saito, Shinjiro, Uchino, Shigehiko, Yamakawa, Kazuma, Kudo, Daisuke, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, Mayumi, Toshihiko, Azuhata, Takeo, Ito, Fumihito, Yoshihiro, Shodai, Hayakawa, Katsura, Nakashima, Tsuyoshi, Ogura, Takayuki, Noda, Eiichiro, Nakamura, Yoshihiko, Sekine, Ryosuke, Yoshikawa, Yoshiaki, Sekino, Motohiro, Ueno, Keiko, Okuda, Yuko, Watanabe, Masayuki, Tampo, Akihito, Saito, Nobuyuki, Kitai, Yuya, Takahashi, Hiroki, Kobayashi, Iwao, Kondo, Yutaka, Matsunaga, Wataru, Nachi, Sho, Miike, Toru, Takahashi, Hiroshi, Takauji, Shuhei, Umakoshi, Kensuke, Todaka, Takafumi, Kodaira, Hiroshi, Andoh, Kohkichi, Kasai, Takehiko, Iwashita, Yoshiaki, Arai, Hideaki, Murata, Masato, Yamane, Masahiro, Shiga, Kazuhiro, and Hori, Naoto

Abstract

Severe sepsis is a major concern in the intensive care unit (ICU), although there is very little epidemiological information regarding severe sepsis in Japan. This study evaluated 3195 patients with severe sepsis in 42 ICUs throughout Japan. The patients with severe sepsis had a mean age of 70 +/- 15 years and a mean Acute Physiology and Chronic Health Evaluation II score of 23 +/- 9. The estimated survival rates at 28 and 90 days after ICU admission were 73.6 and 56.3 %, respectively.

Published
2016

20. Characteristics, treatments, and outcomes of severe sepsis of 3195 ICU-treated adult patients throughout Japan during 2011-2013

Author

1000010374282, Hayakawa, Mineji, Saito, Shinjiro, Uchino, Shigehiko, Yamakawa, Kazuma, 1000030455844, Kudo, Daisuke, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, Mayumi, Toshihiko, Azuhata, Takeo, Ito, Fumihito, Yoshihiro, Shodai, Hayakawa, Katsura, Nakashima, Tsuyoshi, Ogura, Takayuki, Noda, Eiichiro, Nakamura, Yoshihiko, Sekine, Ryosuke, Yoshikawa, Yoshiaki, 1000040380927, Sekino, Motohiro, Ueno, Keiko, Okuda, Yuko, Watanabe, Masayuki, 1000080531524, Tampo, Akihito, Saito, Nobuyuki, Kitai, Yuya, Takahashi, Hiroki, Kobayashi, Iwao, Kondo, Yutaka, Matsunaga, Wataru, 1000030452155, Nachi, Sho, Miike, Toru, Takahashi, Hiroshi, Takauji, Shuhei, Umakoshi, Kensuke, Todaka, Takafumi, Kodaira, Hiroshi, Andoh, Kohkichi, Kasai, Takehiko, Iwashita, Yoshiaki, Arai, Hideaki, Murata, Masato, Yamane, Masahiro, Shiga, Kazuhiro, Hori, Naoto, 1000010374282, Hayakawa, Mineji, Saito, Shinjiro, Uchino, Shigehiko, Yamakawa, Kazuma, 1000030455844, Kudo, Daisuke, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, Mayumi, Toshihiko, Azuhata, Takeo, Ito, Fumihito, Yoshihiro, Shodai, Hayakawa, Katsura, Nakashima, Tsuyoshi, Ogura, Takayuki, Noda, Eiichiro, Nakamura, Yoshihiko, Sekine, Ryosuke, Yoshikawa, Yoshiaki, 1000040380927, Sekino, Motohiro, Ueno, Keiko, Okuda, Yuko, Watanabe, Masayuki, 1000080531524, Tampo, Akihito, Saito, Nobuyuki, Kitai, Yuya, Takahashi, Hiroki, Kobayashi, Iwao, Kondo, Yutaka, Matsunaga, Wataru, 1000030452155, Nachi, Sho, Miike, Toru, Takahashi, Hiroshi, Takauji, Shuhei, Umakoshi, Kensuke, Todaka, Takafumi, Kodaira, Hiroshi, Andoh, Kohkichi, Kasai, Takehiko, Iwashita, Yoshiaki, Arai, Hideaki, Murata, Masato, Yamane, Masahiro, Shiga, Kazuhiro, and Hori, Naoto

Abstract

Severe sepsis is a major concern in the intensive care unit (ICU), although there is very little epidemiological information regarding severe sepsis in Japan. This study evaluated 3195 patients with severe sepsis in 42 ICUs throughout Japan. The patients with severe sepsis had a mean age of 70 +/- 15 years and a mean Acute Physiology and Chronic Health Evaluation II score of 23 +/- 9. The estimated survival rates at 28 and 90 days after ICU admission were 73.6 and 56.3 %, respectively.

Published
2016

21. Characteristics, treatments, and outcomes of severe sepsis of 3195 ICU-treated adult patients throughout Japan during 2011–2013

Author

Hayakawa, Mineji, primary, Saito, Shinjiro, additional, Uchino, Shigehiko, additional, Yamakawa, Kazuma, additional, Kudo, Daisuke, additional, Iizuka, Yusuke, additional, Sanui, Masamitsu, additional, Takimoto, Kohei, additional, Mayumi, Toshihiko, additional, Azuhata, Takeo, additional, Ito, Fumihito, additional, Yoshihiro, Shodai, additional, Hayakawa, Katsura, additional, Nakashima, Tsuyoshi, additional, Ogura, Takayuki, additional, Noda, Eiichiro, additional, Nakamura, Yoshihiko, additional, Sekine, Ryosuke, additional, Yoshikawa, Yoshiaki, additional, Sekino, Motohiro, additional, Ueno, Keiko, additional, Okuda, Yuko, additional, Watanabe, Masayuki, additional, Tampo, Akihito, additional, Saito, Nobuyuki, additional, Kitai, Yuya, additional, Takahashi, Hiroki, additional, Kobayashi, Iwao, additional, Kondo, Yutaka, additional, Matsunaga, Wataru, additional, Nachi, Sho, additional, Miike, Toru, additional, Takahashi, Hiroshi, additional, Takauji, Shuhei, additional, Umakoshi, Kensuke, additional, Todaka, Takafumi, additional, Kodaira, Hiroshi, additional, Andoh, Kohkichi, additional, Kasai, Takehiko, additional, Iwashita, Yoshiaki, additional, Arai, Hideaki, additional, Murata, Masato, additional, Yamane, Masahiro, additional, Shiga, Kazuhiro, additional, and Hori, Naoto, additional

Published
2016
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22. Nifekalant Hydrochloride and Amiodarone Hydrochloride Result in Similar Improvements for 24-Hour Survival in Cardiopulmonary Arrest Patients

Author

Amino, Mari, primary, Inokuchi, Sadaki, additional, Nagao, Ken, additional, Nakagawa, Yoshihide, additional, Yoshioka, Koichiro, additional, Ikari, Yuji, additional, Funakoshi, Hiraku, additional, Hayakawa, Katsura, additional, Matsuzaki, Masakazu, additional, Sakurai, Atsushi, additional, Tahara, Yoshio, additional, Yonemoto, Naohiro, additional, Yaguchi, Arino, additional, and Morimura, Naoto, additional

Published
2015
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25. Impact of missing values on the ability of the acute physiology and chronic health evaluation III and Japan risk of death models to predict mortality

Author

Hayakawa, Katsura, Uchino, Shigehiko, Endo, Hideki, Hasegawa, Kazuki, and Kiyota, Kazuya

Abstract

This study assessed model performance of the Acute Physiology and Chronic Health Evaluation (APACHE) III and Japan Risk of Death (JROD) when degraded by the number and category of missing variables. We also examined the impact of missing data on predicted mortality for facilities with missing physiological variables.

Published
2023
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27. [Implementation and management of cardiopulmonary support system].

Author

Hayakawa K and Shimizu K

Subjects
Cardiopulmonary Resuscitation methods, Humans, Intra-Aortic Balloon Pumping methods, Cardiopulmonary Resuscitation instrumentation
Abstract

The cardiopulmonary support with percutaneous cannula and centrifugal pump (percutaneous cardiopulmonary support, PCPS) has been applied to the cardiac arrest patient. Since the introduction of it, PCPS has made many improvements as it is assisted by maneuverable closed circuit with centrifugal pump, and the invention of thin-wall cannula also supported the development of it. Now, PCPS is utilized as cardiopulmonary support for resuscitation. A combination of PCPS and intra-aortic balloon pumping(IABP) reduces afterload and promotes adequate organ perfusion. This manuscript describes attachment to PCPS and IABP, and methods of management. It is continue to be important to have a thorough knowledge of these devices, of which there is the increase in use frequency.

Published
2011

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