1,805 results on '"Hawkins, E"'
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2. AB0739 INCREASED FREQUENCY AND CYTOTOXICITY OF TERMINALLY DIFFERENTIATED CD4 T CELLS ARE ASSOCIATED WITH CMV POSITIVITY IN ACTIVE RHEUMATOID ARTHRITIS
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Yeoh, S. A., primary, Ehrenstein, M., additional, Akbar, A., additional, Mccluskey, D., additional, Chocarro, L., additional, MA, W. T., additional, Janman, D., additional, Evans, J., additional, Hawkins, E., additional, and Tomson, L., additional
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- 2024
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3. POS1467-HPR DEMOGRAPHIC DISPARITIES: A COMPARATIVE ANALYSIS OF RESEARCH COHORT VS. CLINIC POPULATION REPRESENTATIVENESS WITHIN RHEUMATOLOGY
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Buss, G., primary, Hawkins, E., additional, Kale, S., additional, Ahmed, Y., additional, Wilson, R., additional, Tomson, L., additional, Taylor Gotch, R., additional, and Castelino, M., additional
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- 2024
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4. An Evaluation of the Performance of the Twentieth Century Reanalysis Version 3
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Slivinski, L. C., Compo, G. P., Sardeshmukh, P. D., Whitaker, J. S., McColl, C., Allan, R. J., Brohan, P., Yin, X., Smith, C. A., Spencer, L. J., Vose, R. S., Rohrer, M., Conroy, R. P., Schuster, D. C., Kennedy, J. J., Ashcroft, L., Brönnimann, S., Brunet, M., Camuffo, D., Cornes, R., Cram, T. A., Domínguez-Castro, F., Freeman, J. E., Gergis, J., Hawkins, E., Jones, P. D., Kubota, H., Lee, T. C., Lorrey, A. M., Luterbacher, J., Mock, C. J., Przybylak, R. K., Pudmenzky, C., Slonosky, V. C., Tinz, B., Trewin, B., Wang, X. L., Wilkinson, C., Wood, K., and Wyszynski, P.
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- 2021
5. Reversal of Projected European Summer Precipitation Decline in a Stabilizing Climate
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Dittus, A. J., primary, Collins, M., additional, Sutton, R., additional, and Hawkins, E., additional
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- 2024
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6. Generating High-Definition As-Applied Maps for Pneumatic Fertilizer Application Equipment
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Fulton, J. P., primary, Colley III, R., additional, Shearer, S. A., additional, and Hawkins, E. M., additional
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- 2022
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7. Bioresponsive metal–organic frameworks: Rational design and function
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Morozova, S.M., Sharsheeva, A., Morozov, M.I., Vinogradov, A.V., and Hey-Hawkins, E.
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- 2021
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8. Emergence of multivariate climate change signals
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King, AD, Harrington, LJ, Hawkins, E, Paik, S, Lieber, R, Min, S-K, Borowiak, AR, King, AD, Harrington, LJ, Hawkins, E, Paik, S, Lieber, R, Min, S-K, and Borowiak, AR
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The emergence of a climate change signal relative to background variability is a useful metric for understanding local changes and their consequences. Studies have identified emergent signals of climate change, particularly in temperature-based indices with weaker signals found for precipitation metrics. In this study, we adapt climate analogue methods to examine multivariate climate change emergence over the historical period. We use seasonal temperature and precipitation observations and apply a sigma dissimilarity method to demonstrate that large local climate changes may already be identified, particularly in low-latitude regions. The multivariate methodology brings forward the time of emergence by several decades in many areas relative to analysing temperature in isolation. We observed particularly large departures from an early-20th century climate in years when the global warming signal is compounded by an El Niño-influence. The latitudinal dependence in the emergent climate change signal means that lower-income nations have experienced earlier and stronger emergent climate change signals than the wealthiest regions. Analysis based on temperature and precipitation extreme indices finds weaker signals and less evidence of emergence but is hampered by lack of long-running observations in equatorial areas. The framework developed here may be extended to attribution and projections analyses.
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- 2024
9. Differential splenic responses to hyperoxic breathing at high altitude in Sherpa and lowlanders
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Holmström, Pontus K., Harman, T. S., Kalker, A., Steiner, B., Hawkins, E., Jorgensen, K. C., Zhu, K. T., Kunwar, A. J., Thakur, N., Dhungel, S., Sherpa, N., Day, T. A., Schagatay, Erika K., Bigham, A. W., Brutsaert, T. D., Holmström, Pontus K., Harman, T. S., Kalker, A., Steiner, B., Hawkins, E., Jorgensen, K. C., Zhu, K. T., Kunwar, A. J., Thakur, N., Dhungel, S., Sherpa, N., Day, T. A., Schagatay, Erika K., Bigham, A. W., and Brutsaert, T. D.
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The human spleen contracts in response to stress-induced catecholamine secretion, resulting in a temporary rise in haemoglobin concentration ([Hb]). Recent findings highlighted enhanced splenic response to exercise at high altitude in Sherpa, possibly due to a blunted splenic response to hypoxia. To explore the potential blunted splenic contraction in Sherpas at high altitude, we examined changes in spleen volume during hyperoxic breathing, comparing acclimatized Sherpa with acclimatized individuals of lowland ancestry. Our study included 14 non-Sherpa (7 female) residing at altitude for a mean continuous duration of 3 months and 46 Sherpa (24 female) with an average of 4 years altitude exposure. Participants underwent a hyperoxic breathing test at altitude (4300 m; barrometric pressure = ∼430 torr; (Formula presented.) = ∼90 torr). Throughout the test, we measured spleen volume using ultrasonography and monitored oxygen saturation ((Formula presented.)). During rest, Sherpa exhibited larger spleens (226 ± 70 mL) compared to non-Sherpa (165 ± 34 mL; P < 0.001; effect size (ES) = 0.95, 95% CI: 0.3–1.6). In response to hyperoxia, non-Sherpa demonstrated 22 ± 12% increase in spleen size (35 ± 17 mL, 95% CI: 20.7–48.9; P < 0.001; ES = 1.8, 95% CI: 0.93–2.66), while spleen size remained unchanged in Sherpa (−2 ± 13 mL, 95% CI: −2.4 to 7.3; P = 0.640; ES = 0.18, 95% CI: −0.10 to 0.47). Our findings suggest that Sherpa and non-Sherpas of lowland ancestry exhibit distinct variations in spleen volume during hyperoxia at high altitude, potentially indicating two distinct splenic functions. In Sherpa, this phenomenon may signify a diminished splenic response to altitude-related hypoxia at rest, potentially contributing to enhanced splenic contractions during physical stress. Conversely, non-Sherpa experienced a transient increase in spleen size during hyperoxia, indicating an active tonic contraction, which may influence early altitude acclimatization in lowlanders by ra
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- 2024
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10. Effect of phosphonium ionic liquid/Pd ratio on the catalytic activity of palladium nanoparticles in Suzuki cross-coupling reaction
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Arkhipova, D., Ermolaev, V., Miluykov, V., Gaynanova, G., Zakharova, L., Wagner, G., Oeckler, O., and Hey-Hawkins, E.
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- 2020
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11. Precision of grain yield monitors for use in on-farm research strip trials
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Gauci, A. A., primary, Fulton, J. P., additional, Lindsey, A., additional, Shearer, S. A., additional, Barker, D., additional, and Hawkins, E. M., additional
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- 2023
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12. Copper(II) Complexes with N,O-Hybrid Ligands based on Pyridyl-Containing Phospholane Oxides
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Trigulova, K. R., Shamsieva, A. V., Faizullin, R. R., Lönnecke, P., Hey-Hawkins, E., Voloshina, A. D., Musina, E. I., and Karasik, A. A.
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- 2020
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13. New Gold(I) Complexes with 1,5-Diaza-3,7-Diphosphacyclooctanes: Synthesis and Structures
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Spiridonova, Yu. S., Strelnik, I. D., Musina, E. I., Hey-Hawkins, E., Litvinov, I. A., and Karasik, A. A.
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- 2020
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14. Tenofovir pharmacokinetics in pregnancy
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Best, BM, Burchett, S, Li, H, Stek, A, Hu, C, Wang, J, Hawkins, E, Byroads, M, Watts, DH, Smith, E, Fletcher, CV, Capparelli, EV, Mirochnick, M, and Team, International Maternal Pediatric and Adolescent AIDS Clinical Trials P1026s
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HIV/AIDS ,Clinical Research ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Infection ,Reproductive health and childbirth ,Good Health and Well Being ,Adolescent ,Adult ,Anti-HIV Agents ,Area Under Curve ,Female ,HIV Infections ,HIV Protease Inhibitors ,HIV-1 ,Humans ,Male ,Postpartum Period ,Pregnancy ,Pregnancy Complications ,Infectious ,Pregnancy Trimester ,Second ,Pregnancy Trimester ,Third ,Prospective Studies ,Tenofovir ,Young Adult ,antiretrovirals ,HIV ,pregnancy ,prevention of perinatal transmission ,tenofovir ,International Maternal Pediatric and Adolescent AIDS Clinical Trials (IMPAACT) P1026s Team ,Clinical Sciences ,Virology - Abstract
ObjectivesTenofovir disoproxil fumarate (TDF) is increasingly used in the highly active antiretroviral therapy (HAART) regimens of pregnant women, but limited data exist on the pregnancy pharmacokinetics of chronically dosed TDF. This study described tenofovir pharmacokinetics during pregnancy and postpartum.MethodsInternational Maternal Pediatric and Adolescent AIDS Clinical Trials (IMPAACT) P1026s is a prospective, nonblinded pharmacokinetic study of HIV-infected pregnant women that included a cohort receiving 300 mg TDF once daily. Steady-state 24-hour pharmacokinetic profiles were measured at the second and third trimesters, postpartum, and in maternal and umbilical cord samples collected at delivery. Tenofovir was measured by liquid chromatography-mass spectrometry (LC-MS). The target area under the concentration versus time curve from time 0 to 24 h post dose (AUC) was ≥ 1.99 μg h/mL (nonpregnant historical control 10th percentile).ResultsThe median tenofovir AUC was decreased during the second (1.9 μg h/mL) and third (2.4 μg h/mL; P = 0.005) trimesters versus postpartum (3.0 μg h/mL). Tenofovir AUC exceeded the target for two of four women (50%) in the second trimester, 27 of 37 women [73%; 95% confidence interval (CI) 56%, 86%] in the third trimester, and 27 of 32 women (84%; 95% CI 67%, 95%) postpartum (P > 0.05). Median second/third-trimester troughs were lower (39/54 ng/mL) than postpartum (61 ng/mL). Median third-trimester weight was greater for subjects below the target AUC versus those above the target (97.9 versus 74.2 kg, respectively; P = 0.006). The median ratio of cord blood to maternal concentrations was 0.88. No infants were HIV infected.ConclusionsThis study found lower tenofovir AUC and troughs during pregnancy. Transplacental passage with chronic TDF use during pregnancy was high. Standard TDF doses appear to be appropriate for most HIV-infected pregnant women but therapeutic drug monitoring with dose adjustment should be considered in pregnant women with high weight (> 90 kg) or inadequate HIV RNA response.
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- 2015
15. Pharmacokinetics of tenofovir during pregnancy and postpartum.
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Best, BM, Burchett, S, Li, H, Stek, A, Hu, C, Wang, J, Hawkins, E, Byroads, M, Watts, DH, Smith, E, Fletcher, CV, Capparelli, EV, Mirochnick, M, and International Maternal Pediatric and Adolescent AIDS Clinical Trials (IMPAACT) P1026s Team
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International Maternal Pediatric and Adolescent AIDS Clinical Trials (IMPAACT) P1026s Team ,Humans ,HIV-1 ,Pregnancy Complications ,Infectious ,HIV Infections ,HIV Protease Inhibitors ,Anti-HIV Agents ,Area Under Curve ,Prospective Studies ,Postpartum Period ,Pregnancy ,Pregnancy Trimester ,Second ,Pregnancy Trimester ,Third ,Adolescent ,Adult ,Female ,Male ,Young Adult ,Tenofovir ,HIV ,antiretrovirals ,pregnancy ,prevention of perinatal transmission ,tenofovir ,Pregnancy Complications ,Infectious ,Pregnancy Trimester ,Second ,Third ,Virology ,Clinical Sciences - Abstract
ObjectivesTenofovir disoproxil fumarate (TDF) is increasingly used in the highly active antiretroviral therapy (HAART) regimens of pregnant women, but limited data exist on the pregnancy pharmacokinetics of chronically dosed TDF. This study described tenofovir pharmacokinetics during pregnancy and postpartum.MethodsInternational Maternal Pediatric and Adolescent AIDS Clinical Trials (IMPAACT) P1026s is a prospective, nonblinded pharmacokinetic study of HIV-infected pregnant women that included a cohort receiving 300 mg TDF once daily. Steady-state 24-hour pharmacokinetic profiles were measured at the second and third trimesters, postpartum, and in maternal and umbilical cord samples collected at delivery. Tenofovir was measured by liquid chromatography-mass spectrometry (LC-MS). The target area under the concentration versus time curve from time 0 to 24 h post dose (AUC) was ≥ 1.99 μg h/mL (nonpregnant historical control 10th percentile).ResultsThe median tenofovir AUC was decreased during the second (1.9 μg h/mL) and third (2.4 μg h/mL; P = 0.005) trimesters versus postpartum (3.0 μg h/mL). Tenofovir AUC exceeded the target for two of four women (50%) in the second trimester, 27 of 37 women [73%; 95% confidence interval (CI) 56%, 86%] in the third trimester, and 27 of 32 women (84%; 95% CI 67%, 95%) postpartum (P > 0.05). Median second/third-trimester troughs were lower (39/54 ng/mL) than postpartum (61 ng/mL). Median third-trimester weight was greater for subjects below the target AUC versus those above the target (97.9 versus 74.2 kg, respectively; P = 0.006). The median ratio of cord blood to maternal concentrations was 0.88. No infants were HIV infected.ConclusionsThis study found lower tenofovir AUC and troughs during pregnancy. Transplacental passage with chronic TDF use during pregnancy was high. Standard TDF doses appear to be appropriate for most HIV-infected pregnant women but therapeutic drug monitoring with dose adjustment should be considered in pregnant women with high weight (> 90 kg) or inadequate HIV RNA response.
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- 2015
16. Characterizing a Dramatic $\Delta V\sim-9$ Flare on an Ultracool Dwarf Found by the ASAS-SN Survey
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Schmidt, Sarah J., Prieto, Jose L., Stanek, K. Z., Shappee, Benjamin J., Morrell, Nidia, Gagliuffi, Daniella C. Bardalez, Kochanek, C. S., Jencson, J., Holoien, T. W-S., Basu, U., Beacom, John. F., Szczygiel, D. M., Pojmanski, G., Brimacombe, J., Dubberley, M., Elphick, M., Foale, S., Hawkins, E., Mullins, D., Rosing, W., Ross, R., and Walker, Z.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
We analyze a $\Delta V\sim-9$ magnitude flare on the newly identified M8 dwarf SDSS J022116.84+194020.4 (hereafter SDSSJ0221) detected as part of the All-Sky Automated Survey for Supernovae (ASAS-SN). Using infrared and optical spectra, we confirm that SDSSJ0221 is a relatively nearby (d$\sim$76 pc) M8 dwarf with strong quiescent H$\alpha$ emission. Based on kinematics and the absence of features consistent with low-gravity (young) ultracool dwarfs, we place a lower limit of 200 Myr on the age of SDSSJ0221. When modeled with a simple, classical flare light-curve, this flare is consistent with a total $U$-band flare energy $E_U\sim$ 10$^{34}$ erg, confirming that the most dramatic flares are not limited to warmer, more massive stars. Scaled to include a rough estimate of the emission line contribution to the $V$ band, we estimate a blackbody filling factor of $\sim$$10-30\%$ during the flare peak and $\sim$$0.5-1.6\%$ during the flare decay phase. These filling factors correspond to flare areas that are an order of magnitude larger than those measured for most mid-M dwarf flares., Comment: Updated version in response to referee report. 6 pages, 3 figures, 2 tables. Submitted to ApJL. For a brief video explaining this paper, see http://youtu.be/uue8G0NnjJU
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- 2013
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17. The Man Behind the Curtain: X-rays Drive the UV through NIR Variability in the 2013 AGN Outburst in NGC 2617
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Shappee, B. J., Prieto, J. L., Grupe, D., Kochanek, C. S., Stanek, K. Z., De Rosa, G., Mathur, S., Zu, Y., Peterson, B. M., Pogge, R. W., Komossa, S., Im, M., Jencson, J., Holoien, T. W-S., Basu, U., Beacom, J. F., Szczygiel, D. M., Brimacombe, J., Adams, S., Campillay, A., Choi, C., Contreras, C., Dietrich, M., Dubberley, M., Elphick, M., Foale, S., Giustini, M., Gonzalez, C., Hawkins, E., Howell, D. A., Hsiao, E. Y., Koss, M., Leighly, K. M., Morrell, N., Mudd, D., Mullins, D., Nugent, J. M., Parrent, J., Phillips, M. M., Pojmanski, G., Rosing, W., Ross, R., Sand, D., Terndrup, D. M., Valenti, S., Walker, Z., and Yoon, Y.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
After the All-Sky Automated Survey for SuperNovae (ASAS-SN) discovered a significant brightening of the inner region of NGC 2617, we began a ~70 day photometric and spectroscopic monitoring campaign from the X-ray through near-infrared (NIR) wavelengths. We report that NGC 2617 went through a dramatic outburst, during which its X-ray flux increased by over an order of magnitude followed by an increase of its optical/ultraviolet (UV) continuum flux by almost an order of magnitude. NGC 2617, classified as a Seyfert 1.8 galaxy in 2003, is now a Seyfert 1 due to the appearance of broad optical emission lines and a continuum blue bump. Such "changing look Active Galactic Nuclei (AGN)" are rare and provide us with important insights about AGN physics. Based on the Hbeta line width and the radius-luminosity relation, we estimate the mass of central black hole to be (4 +/- 1) x 10^7 M_sun. When we cross-correlate the light curves, we find that the disk emission lags the X-rays, with the lag becoming longer as we move from the UV (2-3 days) to the NIR (6-9 days). Also, the NIR is more heavily temporally smoothed than the UV. This can largely be explained by a simple model of a thermally emitting thin disk around a black hole of the estimated mass that is illuminated by the observed, variable X-ray fluxes., Comment: 36 pages, 11 figures, 3 Tables. Accepted for publication in ApJ. Spectroscopic and photometric data presented in this submission are included as ancillary files. To see a video of the Swift UV/optical data see http://youtu.be/XuG6uhx-zs4 For a brief video explaining this paper, see http://youtu.be/W4RXTNHCh-g
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- 2013
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18. Las Cumbres Observatory Global Telescope Network
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Brown, T. M., Baliber, N., Bianco, F. B., Bowman, M., Burleson, B., Conway, P., Crellin, M., Depagne, É., De Vera, J., Dilday, B., Dragomir, D., Dubberley, M., Eastman, J. D., Elphick, M., Falarski, M., Foale, S., Ford, M., Fulton, B. J., Garza, J., Gomez, E. L., Graham, M., Greene, R., Haldeman, B., Hawkins, E., Haworth, B., Haynes, R., Hidas, M., Hjelstrom, A. E., Howell, D. A., Hygelund, J., Lister, T. A., Lobdill, R., Martinez, J., Mullins, D. S., Norbury, M., Parrent, J., Paulson, R., Petry, D. L., Pickles, A., Posner, V., Rosing, W. E., Ross, R., Sand, D. J., Saunders, E. S., Shobbrook, J., Shporer, A., Street, R. A., Thomas, D., Tsapras, Y., Tufts, J. R., Valenti, S., Horst, K. Vander, Walker, Z., White, G., and Willis, M.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Las Cumbres Observatory Global Telescope (LCOGT) is a young organization dedicated to time-domain observations at optical and (potentially) near-IR wavelengths. To this end, LCOGT is constructing a world-wide network of telescopes, including the two 2m Faulkes telescopes, as many as 17 x 1m telescopes, and as many as 23 x 40cm telescopes. These telescopes initially will be outfitted for imaging and (excepting the 40cm telescopes) spectroscopy at wavelengths between the atmospheric UV cutoff and the roughly 1-micron limit of silicon detectors. Since the first of LCOGT's 1m telescopes are now being deployed, we lay out here LCOGT's scientific goals and the requirements that these goals place on network architecture and performance, we summarize the network's present and projected level of development, and we describe our expected schedule for completing it. In the bulk of the paper, we describe in detail the technical approaches that we have adopted to attain the desired performance. In particular, we discuss our choices for the number and location of network sites, for the number and sizes of telescopes, for the specifications of the first generation of instruments, for the software that will schedule and control the network's telescopes and reduce and archive its data, and for the structure of the scientific and educational programs for which the network will provide observations., Comment: 59 pages, 9 figures, 4 tables. AAS Latex v5.2. Accepted for publication in Pub. Astr. Soc. Pacific
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- 2013
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19. Comment on: 'On the consistency of solutions of the space fractional Schr\'odinger equation'
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Hawkins, E. and Schwarz, J. M.
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Mathematical Physics - Abstract
In [J. Math. Phys. 53, 042105 (2012)], Bay{\i}n claims to prove the consistency of the purported piece-wise solutions to the fractional Schr\"odinger equation for an infinite square well. However, his calculation uses standard contour integral techniques despite the absence of an analytic integrand. The correct calculation is presented and supports our earlier work proving that the purported piece-wise solutions do not solve the fractional Schr\"odinger equation for an infinite square well [M. Jeng, S.-L.-Y. Xu, E. Hawkins, and J. M. Schwarz, J. Math. Phys. 51, 062102 (2010)]., Comment: 5 pages. 3 figures. This is a comment on arXiv:1203.4556 [math-ph]
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- 2012
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20. IR and Raman spectroscopy: monitoring immobilization of some anticancer organotin(IV) compounds on mesoporous silica
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Popp, Jürgen, Gergely, Csilla, Ivanovski, V., Becker, T., Predarska, I., Hey-Hawkins, E., and Kaluđerović, G. N.
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- 2024
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21. OGLE 2008--BLG--290: An accurate measurement of the limb darkening of a Galactic Bulge K Giant spatially resolved by microlensing
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Fouque, P., Heyrovsky, D., Dong, S., Gould, A., Udalski, A., Albrow, M. D., Batista, V., Beaulieu, J. -P., Bennett, D. P., Bond, I. A., Bramich, D. M., Novati, S. Calchi, Cassan, A., Coutures, C., Dieters, S., Dominik, M., Prester, D. Dominis, Greenhill, J., Horne, K., Jorgensen, U. G., Kozlowski, S., Kubas, D., Lee, C. -H., Marquette, J. -B., Mathiasen, M., Menzies, J., Monard, L. A. G., Nishiyama, S., Papadakis, I., Street, R., Sumi, T., Williams, A., Yee, J. C., Brillant, S., Caldwell, J. A. R., Cole, A., Cook, K. H., Donatowicz, J., Kains, N., Kane, S. R., Martin, R., Pollard, K. R., Sahu, K. C., Tsapras, Y., Wambsganss, J., Zub, M., DePoy, D. L., Gaudi, B. S., Han, C., Lee, C. -U., Park, B. -G., Pogge, R. W., Kubiak, M., Szymanski, M. K., Pietrzynski, G., Soszynski, I., Szewczyk, O., Ulaczyk, K., Wyrzykowski, L., Abe, F., Fukui, A., Furusawa, K., Gilmore, A. C., Hearnshaw, J. B., Itow, Y., Kamiya, K., Kilmartin, P. M., Korpela, A. V., Lin, W., Ling, C. H., Masuda, K., Matsubara, Y., Miyake, N., Muraki, Y., Nagaya, M., Ohnishi, K., Okumura, T., Perrott, Y., Rattenbury, N. J., Saito, To., Sako, T., Sato, S., Skuljan, L., Sullivan, D., Sweatman, W., Tristram, P. J., Yock, P. C. M., Allan, A., Bode, M. F., Burgdorf, M. J., Clay, N., Fraser, S. N., Hawkins, E., Kerins, E., Lister, T. A., Mottram, C. J., Saunders, E. S., Snodgrass, C., Steele, I. A., Wheatley, P. J., Anguita, T., Bozza, V., Harpsoe, K., Hinse, T. C., Hundertmark, M., Kjaergaard, P., Liebig, C., Mancini, L., Masi, G., Rahvar, S., Ricci, D., Scarpetta, G., Southworth, J., Surdej, J., Thone, C. C., Riffeser, A., Seitz, S., and Bender, R.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Gravitational microlensing is not only a successful tool for discovering distant exoplanets, but it also enables characterization of the lens and source stars involved in the lensing event. In high magnification events, the lens caustic may cross over the source disk, which allows a determination of the angular size of the source and additionally a measurement of its limb darkening. When such extended-source effects appear close to maximum magnification, the resulting light curve differs from the characteristic Paczynski point-source curve. The exact shape of the light curve close to the peak depends on the limb darkening of the source. Dense photometric coverage permits measurement of the respective limb-darkening coefficients. In the case of microlensing event OGLE 2008-BLG-290, the K giant source star reached a peak magnification of about 100. Thirteen different telescopes have covered this event in eight different photometric bands. Subsequent light-curve analysis yielded measurements of linear limb-darkening coefficients of the source in six photometric bands. The best-measured coefficients lead to an estimate of the source effective temperature of about 4700 +100-200 K. However, the photometric estimate from colour-magnitude diagrams favours a cooler temperature of 4200 +-100 K. As the limb-darkening measurements, at least in the CTIO/SMARTS2 V and I bands, are among the most accurate obtained, the above disagreement needs to be understood. A solution is proposed, which may apply to previous events where such a discrepancy also appeared., Comment: Astronomy & Astrophysics in press
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- 2010
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22. Raltegravir pharmacokinetics during pregnancy
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Watts, DH, Stek, A, Best, BM, Wang, J, Capparelli, EV, Cressey, TR, Aweeka, F, Lizak, P, Kreitchmann, R, Burchett, SK, Shapiro, DE, Hawkins, E, Smith, E, and Mirochnick, M
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Virology ,Clinical Sciences - Abstract
OBJECTIVE: We evaluated the pharmacokinetics (pk) of raltegravir in HIV-infected women during pregnancy and postpartum. METHODS: IMPAACT 1026s is an on-going prospective study of antiretroviral pk during pregnancy (NCT00042289). Women receiving 400 mg raltegravir twice daily in combination antiretroviral therapy had intensive steady state 12-hour pk profiles performed during pregnancy and at 6-12 weeks postpartum. Targets were trough concentration above 0.035 μg/mL, the estimated tenth percentile in non-pregnant historical controls. RESULTS: Median raltegravir AUC was 6.6 μg*hr/mL for second trimester (n= 16), 5.4 μg*hr/mL for third trimester (n=41), and 11.6 μg*hr/mL postpartum (n= 38) (p=0.03 pp vs 2 trimester, p=0.001 pp vs third trimester). Trough concentrations were above the target in 69%, 80%, and 79% of second trimester, third trimester and postpartum subjects respectively, with wide variability ( < 0.010-0.917 μg/mL), and no significant difference between third trimester and postpartum trough concentrations was detected. The median ratio of cord blood/maternal raltegravir concentrations was 1.5. HIV RNA levels were < 400 copies/mL in 92% of women at delivery. Adverse events included elevated liver transaminases in one woman and vomiting in one. All infants with known status are HIV-uninfected. CONCLUSIONS: Median raltegravir AUC was reduced by approximately 50% during pregnancy; trough concentrations were frequently below target both during late pregnancy and postpartum. Raltegravir readily crossed the placenta. High rates of viral suppression at delivery and the lack of a clear relationship between raltegravir concentration and virologic effect in nonpregnant adults suggest that despite the decreased exposure during pregnancy, a higher dose is not necessary.
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- 2014
23. THE MAN BEHIND THE CURTAIN: X-RAYS DRIVE THE UV THROUGH NIR VARIABILITY IN THE 2013 ACTIVE GALACTIC NUCLEUS OUTBURST IN NGC 2617
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Shappee, BJ, Prieto, JL, Grupe, D, Kochanek, CS, Stanek, KZ, De Rosa, G, Mathur, S, Zu, Y, Peterson, BM, Pogge, RW, Komossa, S, Im, M, Jencson, J, Holoien, TW-S, Basu, U, Beacom, JF, Szczygieł, DM, Brimacombe, J, Adams, S, Campillay, A, Choi, C, Contreras, C, Dietrich, M, Dubberley, M, Elphick, M, Foale, S, Giustini, M, Gonzalez, C, Hawkins, E, Howell, DA, Hsiao, EY, Koss, M, Leighly, KM, Morrell, N, Mudd, D, Mullins, D, Nugent, JM, Parrent, J, Phillips, MM, Pojmanski, G, Rosing, W, Ross, R, Sand, D, Terndrup, DM, Valenti, S, Walker, Z, and Yoon, Y
- Subjects
galaxies&COLFAML active ,galaxies&COLFAML nuclei ,galaxies&COLFAML Seyfert ,line&COLFAML formation ,line&COLFAML profiles ,astro-ph.HE ,astro-ph.CO ,Astronomical and Space Sciences ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Physical Chemistry (incl. Structural) ,Astronomy & Astrophysics - Abstract
After the All-Sky Automated Survey for SuperNovae discovered a significant brightening of the inner region of NGC 2617, we began a ∼70 day photometric and spectroscopic monitoring campaign from the X-ray through near-infrared (NIR) wavelengths. We report that NGC 2617 went through a dramatic outburst, during which its X-ray flux increased by over an order of magnitude followed by an increase of its optical/ultraviolet (UV) continuum flux by almost an order of magnitude. NGC 2617, classified as a Seyfert 1.8 galaxy in 2003, is now a Seyfert 1 due to the appearance of broad optical emission lines and a continuum blue bump. Such "changing look active galactic nuclei (AGNs)" are rare and provide us with important insights about AGN physics. Based on the Hβ line width and the radius-luminosity relation, we estimate the mass of central black hole (BH) to be (4 ± 1) × 107 M . When we cross-correlate the light curves, we find that the disk emission lags the X-rays, with the lag becoming longer as we move from the UV (2-3 days) to the NIR (6-9 days). Also, the NIR is more heavily temporally smoothed than the UV. This can largely be explained by a simple model of a thermally emitting thin disk around a BH of the estimated mass that is illuminated by the observed, variable X-ray fluxes. © 2014. The American Astronomical Society. All rights reserved..
- Published
- 2014
24. On the nonlocality of the fractional Schr\'{o}dinger equation
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Jeng, M., Xu, S. -L. -Y., Hawkins, E., and Schwarz, J. M.
- Subjects
Mathematical Physics ,Quantum Physics - Abstract
A number of papers over the past eight years have claimed to solve the fractional Schr\"{o}dinger equation for systems ranging from the one-dimensional infinite square well to the Coulomb potential to one-dimensional scattering with a rectangular barrier. However, some of the claimed solutions ignore the fact that the fractional diffusion operator is inherently nonlocal, preventing the fractional Schr\"{o}dinger equation from being solved in the usual piecewise fashion. We focus on the one-dimensional infinite square well and show that the purported groundstate, which is based on a piecewise approach, is definitely not a solution of the fractional Schr\"{o}dinger equation for general fractional parameters $\alpha$. On a more positive note, we present a solution to the fractional Schr\"{o}dinger equation for the one-dimensional harmonic oscillator with $\alpha=1$., Comment: 5 pages
- Published
- 2008
25. RoboNet-II: Follow-up observations of microlensing events with a robotic network of telescopes
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Tsapras, Y., Street, R., Horne, K., Snodgrass, C., Dominik, M., Allan, A., Steele, I., Bramich, D. M., Saunders, E. S., Rattenbury, N., Mottram, C., Fraser, S., Clay, N., Burgdorf, M., Bode, M., Lister, T. A., Hawkins, E., Beaulieu, J. P., Fouque, P., Albrow, M., Menzies, J., Cassan, A., and Dominis-Prester, D.
- Subjects
Astrophysics - Abstract
RoboNet-II uses a global network of robotic telescopes to perform follow-up observations of microlensing events in the Galactic Bulge. The current network consists of three 2m telescopes located in Hawaii and Australia (owned by Las Cumbres Observatory) and the Canary Islands (owned by Liverpool John Moores University). In future years the network will be expanded by deploying clusters of 1m telescopes in other suitable locations. A principal scientific aim of the RoboNet-II project is the detection of cool extra-solar planets by the method of gravitational microlensing. These detections will provide crucial constraints to models of planetary formation and orbital migration. RoboNet-II acts in coordination with the PLANET microlensing follow-up network and uses an optimization algorithm ("web-PLOP") to select the targets and a distributed scheduling paradigm (eSTAR) to execute the observations. Continuous automated assessment of the observations and anomaly detection is provided by the ARTEMiS system., Comment: 8 pages, 4 figures. Astronomical Notes - accepted. Changes:*spelling corrections and rewording. *Expanded sections on how the software interacts to further clarify the procedure. *Clarified further minor points as requested by the referee
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- 2008
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26. On the relationship between sigma models and spin chains
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Controzzi, D. and Hawkins, E.
- Subjects
Condensed Matter - Strongly Correlated Electrons - Abstract
We consider the two-dimensional $\rm O(3)$ non-linear sigma model with topological term using a lattice regularization introduced by Shankar and Read [Nucl.Phys. B336 (1990), 457], that is suitable for studying the strong coupling regime. When this lattice model is quantized, the coefficient $\theta$ of the topological term is quantized as $\theta=2\pi s$, with $s$ integer or half-integer. We study in detail the relationship between the low energy behaviour of this theory and the one-dimensional spin-$s$ Heisenberg model. We generalize the analysis to sigma models with other symmetries., Comment: To appear in Int. J. MOd. Phys. B
- Published
- 2005
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27. The nature of the relative bias between galaxies of different spectral type in 2dFGRS
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Conway, E., Maddox, S., Wild, V., Peacock, J. A., Hawkins, E., Norberg, P., Madgwick, D. S., Baldry, I. K., Baugh, C. M., Bland-Hawthorn, J., Bridges, T., Cannon, R., Cole, S., Colless, M., Collins, C., Couch, W., Dalton, G., De Propris, R., Driver, S. P., Efstathiou, G., Ellis, R. S., Frenk, C. S., Glazebrook, K., Jackson, C., Jones, B., Lahav, O., Lewis, I., Lumsden, S., Percival, W., Peterson, B. A., Sutherland, W., and Taylor, K.
- Subjects
Astrophysics - Abstract
We present an analysis of the relative bias between early- and late-type galaxies in the Two-degree Field Galaxy Redshift Survey (2dFGRS). Our analysis examines the joint counts in cells between early- and late-type galaxies, using approximately cubical cells with sides ranging from 7h^{-1}Mpc to 42h^{-1}Mpc. We measure the variance of the counts in cells using the method of Efstathiou et al. (1990), which we find requires a correction for a finite volume effect. We fit lognormal models to the one-point density distribution and develop methods of dealing with biases in the recovered variances resulting from this technique. We directly fit deterministic models for the joint density distribution function, f(delta_E,delta_L), to the joint counts in cells using a maximum likelihood technique. Our results are consistent with a scale invariant relative bias factor on all scales studied. Linear bias is ruled out on scales less than l=28h^{-1}Mpc. A power-law bias model is a significantly better fit to the data on all but the largest scales studied; the relative goodness of fit of this model as compared to that of the linear bias model suggests that any nonlinearity is negligible for l>~40h^{-1}Mpc, consistent with the expectation from theory that the bias should become linear on large scales. (abridged), Comment: 19 pages, 17 figures, submitted to MNRAS
- Published
- 2004
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28. The 2dF Galaxy Redshift Survey: galaxy clustering per spectral type
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Madgwick, D. S., Hawkins, E., Lahav, O., Maddox, S., Norberg, P., Peacock, J., Baldry, I. K., Baugh, C. M., Bland-Hawthorn, J., Bridges, T., Cannon, R., Cole, S., Colless, M., Collins, C., Couch, W., Dalton, G., De Propris, R., Driver, S. P., Efstathiou, G., Ellis, R. S., Frenk, C. S., Glazebrook, K., Jackson, C., Lewis, I., Lumsden, S., Peterson, B. A., Sutherland, W., and Taylor, K.
- Subjects
Astrophysics - Abstract
We have calculated the two-point correlation functions in redshift space, xi(sigma,pi), for galaxies of different spectral types in the 2dF Galaxy Redshift Survey. Using these correlation functions we are able to estimate values of the linear redshift-space distortion parameter, beta = Omega_m^0.6/b, the pairwise velocity dispersion, a, and the real-space correlation function, xi(r), for galaxies with both relatively low star-formation rates (for which the present rate of star formation is less than 10% of its past averaged value) and galaxies with higher current star-formation activity. At small separations, the real-space clustering of passive galaxies is very much stronger than that of the more actively star-forming galaxies; the correlation-function slopes are respectively 1.93 and 1.50, and the relative bias between the two classes is a declining function of radius. On scales larger than 10 h^-1 Mpc there is evidence that the relative bias tends to a constant, b(passive)/b(active) ~ 1. This result is consistent with the similar degrees of redshift-space distortions seen in the correlation functions of the two classes -- the contours of xi(sigma,pi) require beta(active)=0.49+/-0.13, and beta(passive)=0.48+/-0.14. The pairwise velocity dispersion is highly correlated with beta. However, despite this a significant difference is seen between the two classes. Over the range 8-20 h^-1 Mpc, the pairwise velocity dispersion has mean values 416+/-76 km/s and 612+/-92 km/s for the active and passive galaxy samples respectively. This is consistent with the expectation from morphological segregation, in which passively evolving galaxies preferentially inhabit the cores of high-mass virialised regions., Comment: 10 pages, 7 figures. Submitted to MNRAS
- Published
- 2003
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29. The 2dF Galaxy Redshift Survey: the luminosity function of cluster galaxies
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De Propris, Roberto, Colless, M., Driver, S., Couch, W., Peacock, J., Baldry, I., Baugh, C., Collins, C., Bland-Hawthorn, J., Bridges, T., Cannon, R., Cole, S., Cross, N., Dalton, G. B., Efstathiou, G., Ellis, R. S., Frenk, C. S., Glazebrook, K., Hawkins, E., Jackson, C., Lahav, O., Lewis, I., Lumsden, S., Maddox, S., Madgwick, D. S., Norberg, P., Percival, W., Peterson, B., Sutherland, W., and Taylor, K.
- Subjects
Astrophysics - Abstract
We have determined the composite luminosity function (LF) for galaxies in 60 clusters from the 2dF Galaxy Redshift Survey. The LF spans the range $-22.5
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- 2002
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30. The 2dF Galaxy Redshift Survey: correlation functions, peculiar velocities and the matter density of the Universe
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Hawkins, E., Maddox, S., Cole, S., Lahav, O., Madgwick, D., Norberg, P., Peacock, J., Baldry, I., Baugh, C., Bland-Hawthorn, J., Bridges, T., Cannon, R., Colless, M., Collins, C., Couch, W., Dalton, G., De Propris, R., Driver, S., Efstathiou, G., Ellis, R., Frenk, C., Glazebrook, K., Jackson, C., Jones, B., Lewis, I., Lumsden, S., Percival, W., Peterson, B., Sutherland, W., and Taylor, K.
- Subjects
Astrophysics - Abstract
We present a detailed analysis of the two-point correlation function, from the 2dF Galaxy Redshift Survey (2dFGRS). We estimate the redshift-space correlation function, xi(s), from which we measure the redshift-space clustering length, s_0=6.82+/-0.28 Mpc/h. We also estimate the projected correlation function, Xi(sigma), and the real-space correlation function, xi(r), which can be fit by a power-law, with r_0=5.05+/-0.26Mpc/h, gamma_r=1.67+/-0.03. For r>20Mpc/h, xi drops below a power-law as is expected in the popular LCDM model. The ratio of amplitudes of the real and redshift-space correlation functions on scales of 8-30Mpc/h gives an estimate of the redshift-space distortion parameter beta. The quadrupole moment of xi on scales 30-40Mpc/h provides another estimate of beta. We also estimate the distribution function of pairwise peculiar velocities, f(v), including rigorously the effect of infall velocities, and find that it is well fit by an exponential. The accuracy of our xi measurement is sufficient to constrain a model, which simultaneously fits the shape and amplitude of xi(r) and the two redshift-space distortion effects parameterized by beta and velocity dispersion, a. We find beta=0.49+/-0.09 and a=506+/-52km/s, though the best fit values are strongly correlated. We measure the variation of the peculiar velocity dispersion with projected separation, a(sigma), and find that the shape is consistent with models and simulations. Using the constraints on bias from recent estimates, and taking account of redshift evolution, we conclude that beta(L=L*,z=0)=0.47+/-0.08, and that the present day matter density of the Universe is 0.3, consistent with other 2dFGRS estimates and independent analyses., Comment: 19 pages, revised following referee's report, and accepted by MNRAS. Higher resolution Figures, an animated version of Figure 12 and a colour version of Figure 22 are available from http://www.nottingham.ac.uk/~ppxeh/
- Published
- 2002
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31. No Periodicities in 2dF Redshift Survey Data
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Hawkins, E., Maddox, S. J., and Merrifield, M. R.
- Subjects
Astrophysics - Abstract
We have used the publicly available data from the 2dF Galaxy Redshift Survey and the 2dF QSO Redshift Survey to test the hypothesis that there is a periodicity in the redshift distribution of quasi-stellar objects (QSOs) found projected close to foreground galaxies. These data provide by far the largest and most homogeneous sample for such a study, yielding 1647 QSO-galaxy pairs. There is no evidence for a periodicity at the predicted frequency in log(1+z), or at any other frequency., Comment: 4 pages, 5 figures, MNRAS accepted
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- 2002
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32. The 2dF Galaxy Redshift Survey: The dependence of galaxy clustering on luminosity and spectral type
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Norberg, P., Baugh, C. M., Hawkins, E., Maddox, S., Madgwick, D., Lahav, O., Cole, S., Frenk, C. S., Baldry, I., Bland-Hawthorn, J., Bridges, T., Cannon, R., Colless, M., Collins, C., Couch, W., Dalton, G., Driver, S. P., Efstathiou, G., Ellis, R. S., Glazebrook, K., Jackson, C., Lewis, I., Lumsden, S., Peacock, J. A., Peterson, B. A., Sutherland, W., Taylor, K., and Team, the 2dFGRS
- Subjects
Astrophysics - Abstract
We investigate the dependence of galaxy clustering on luminosity and spectral type using the 2dF Galaxy Redshift Survey (2dFGRS). Spectral types are assigned using the principal component analysis of Madgwick et al. We divide the sample into two broad spectral classes: galaxies with strong emission lines (`late-types'), and more quiescent galaxies (`early-types'). We measure the clustering in real space, free from any distortion of the clustering pattern due to peculiar velocities, for a series of volume-limited samples. The projected correlation functions of both spectral types are well described by a power law for transverse separations in the range 2 < (sigma/Mpc/h) < 15, with a marginally steeper slope for early-types than late-types. Both early and late types have approximately the same dependence of clustering strength on luminosity, with the clustering amplitude increasing by a factor of ~2.5 between L* and 4 L*. At all luminosities, however, the correlation function amplitude for the early-types is ~50% higher than that of the late-types. These results support the view that luminosity, and not type, is the dominant factor in determining how the clustering strength of the whole galaxy population varies with luminosity., Comment: accepted by MNRAS after minor revision. 13 pages, 10 figures
- Published
- 2001
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33. The 2dF Galaxy Redshift Survey: constraints on cosmic star-formation history from the cosmic spectrum
- Author
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Baldry, I. K., Glazebrook, K., Baugh, C. M., Bland-Hawthorn, J., Bridges, T., Cannon, R., Cole, S., Colless, M., Collins, C., Couch, W., Dalton, G., De Propris, R., Driver, S. P., Efstathiou, G., Ellis, R. S., Frenk, C. S., Hawkins, E., Jackson, C., Lahav, O., Lewis, I., Lumsden, S., Maddox, S., Madgwick, D. S., Norberg, P., Peacock, J. A., Peterson, B. A., Sutherland, W., and Taylor, K.
- Subjects
Astrophysics - Abstract
We present the first results on the history of star formation in the Universe based on the `cosmic spectrum', in particular, the volume-averaged, luminosity-weighted, stellar absorption line spectrum of present day galaxies from the 2dFGRS. This method is novel in that unlike previous studies it is not an estimator based on total luminosity density. The cosmic spectrum is fitted with models of population synthesis, tracing the history of star formation prior to the epoch of the observed galaxies, using a method we have developed which decouples continuum and spectral-line variations and is robust against spectrophotometric uncertainties. The cosmic spectrum can only be fitted with models incorporating chemical evolution and indicates there was a peak of star-formation rate in the past of at least three times the current value and that the increase back to z=1, assuming it scales as (1+z)^beta, has a strong upper limit of beta<5. We find in the general case there is some model degeneracy between star formation at low and high redshift. However, if we incorporate previous work on star formation at z<1 we can put strong upper limits on the SFR at z>1: e.g., if beta>2 then the SFR for 1
1. Our results are consistent with the best-fit results from compilations of cosmic SFR estimates based on UV luminosity density, which give 1.8 - Published
- 2001
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34. The 2dF Galaxy Redshift Survey: Luminosity dependence of galaxy clustering
- Author
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Norberg, P., Baugh, C. M., Hawkins, E., Maddox, S., Peacock, J. A., Cole, S., Frenk, C. S., Bland-Hawthorn, J., Bridges, T., Cannon, R., Colless, M., Collins, C., Couch, W., Dalton, G., Driver, S. P., Efstathiou, G., Ellis, R. S., Glazebrook, K., Jackson, C., Lahav, O., Lewis, I., Lumsden, S., Peterson, B. A., Sutherland, W., Taylor, K., and Team, the 2dFGRS
- Subjects
Astrophysics - Abstract
We investigate the dependence of the strength of galaxy clustering on intrinsic luminosity using the Anglo-Australian two degree field galaxy redshift survey (2dFGRS). The 2dFGRS is over an order of magnitude larger than previous redshift surveys used to address this issue. We measure the projected two-point correlation function of galaxies in a series of volume-limited samples. The projected correlation function is free from any distortion of the clustering pattern induced by peculiar motions and is well described by a power-law in pair separation over the range 0.1 < r /h Mpc < 10. The clustering of L* galaxies in real space is well fit by a correlation length r0 = 4.9 +/- 0.3 /h Mpc and power-law slope gamma = 1.71 +/- 0.06. The clustering amplitude increases slowly with absolute magnitude for galaxies fainter than M*, but rises more strongly at higher luminosities. At low luminosities, our results agree with measurements from the SSRS2 by Benoist et al. However, we find a weaker dependence of clustering strength on luminosity at the highest luminosities. The correlation function amplitude increases by a factor of 4.0 between $M_{b_{J}} -5\log_{10}h = -18$ and -22.5, and the most luminous galaxies are 3.0 times more strongly clustered than L* galaxies. The power-law slope of the correlation function shows remarkably little variation for samples spanning a factor of 20 in luminosity. Our measurements are in very good agreement with the predictions of the hierarchical galaxy formation models of Benson et al., Comment: Revised to matched published version: 2001, MNRAS, 328, 64. Colour versions of selected figures for use in talks are available at http://star-www.dur.ac.uk/~irpn/public_2dFGRS/2dF_xir/PaperI/
- Published
- 2001
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35. The Clustering of Hot and Cold IRAS Galaxies: The Redshift Space Correlation Function
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Hawkins, E., Maddox, S., Branchini, E., and Saunders, W.
- Subjects
Astrophysics - Abstract
We measure the autocorrelation function of galaxies in the IRAS Point Source Catalogue galaxy redshift (PSCz) survey and investigate its dependence on the far-infrared colour and absolute luminosity of the galaxies. We find that the PSCz survey correlation function can be modelled out to a scale of 10 h^{-1}Mpc as a power law of slope 1.30 +/- 0.04 and correlation length 4.77 +/- 0.20. At a scale of 75 h^{-1}Mpc we find the value of J_3 to be 1500 +/- 400. We also find that galaxies with cooler dust temperatures, are more strongly clustered than warmer galaxies. Splitting the survey into three colour subsamples, we find that, between 1 and 10 h^{-1}Mpc, the ratio of the correlation function is factor of 1.5 higher for the cooler galaxies compared to the hotter galaxies. This is consistent with the suggestion that hotter galaxies have higher star-formation rates, and correspond to later-type galaxies which are less clustered than earlier types. Using volume limited sub-samples, we find a weak variation of the correlation function as a function of absolute luminosity, in the sense that more luminous galaxies are less clustered than fainter galaxies. The trend is consistent with the colour dependence of the correlation function and the observed colour-luminosity correlation, but the large uncertainties mean that it has a low statistical significance., Comment: Accepted by MNRAS. 12 pages, 12 figures
- Published
- 2001
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36. Imaging of Small-Scale Features on 433 Eros from NEAR: Evidence for a Complex Regolith
- Author
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Veverka, J., Thomas, P. C., Robinson, M., Murchie, S., Chapman, C., Bell, M., Harch, A., Merline, W. J., Bell, J. F., Bussey, B., Carcich, B., Cheng, A., Clark, B., Domingue, D., Dunham, D., Farquhar, R., Gaffey, M. J., Hawkins, E., Izenberg, N., Joseph, J., Kirk, R., Li, H., Lucey, P., Malin, M., McFadden, L., Miller, J. K., Owen, W. M., Peterson, C., Prockter, L., Warren, J., Wellnitz, D., Williams, B. G., and Yeomans, D. K.
- Published
- 2001
37. NEAR at Eros: Imaging and Spectral Results
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Veverka, J., Robinson, M., Thomas, P., Murchie, S., Bell, J. F., Izenberg, N., Chapman, C., Harch, A., Bell, M., Carcich, B., Cheng, A., Clark, B., Domingue, D., Dunham, D., Farquhar, R., Gaffey, M. J., Hawkins, E., Joseph, J., Kirk, R., Li, H., Lucey, P., Malin, M., Martin, P., McFadden, L., Merline, W. J., Miller, J. K., Owen, W. M., Peterson, C., Prockter, L., Warren, J., Wellnitz, D., Williams, B. G., and Yeomans, D. K.
- Published
- 2000
38. Novel representatives of 16-membered aminomethylphosphines with alkyl substituents at nitrogen and their gold(I) complexes
- Author
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Musina, E. I., Wittmann, T. I., Lönnecke, P., Hey-Hawkins, E., Karasik, A. A., and Sinyashin, O. G.
- Published
- 2018
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39. POS0205-HPR CHARACTERISATION OF RESEARCH PARTICIPANTS: A PRELIMINARY EXPLORATION USING ELECTRONIC PATIENT CASE RECORDS (EPCR)
- Author
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Ahmed, Y., primary, Hawkins, E., additional, Wilson, R., additional, J’bari, H., additional, Tomson, L., additional, Taylor Gotch, R., additional, Butt, M., additional, and Castelino, M., additional
- Published
- 2023
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40. In vivo performance of different ¹⁸F-labelled cannabinoid receptor 2 radioligands
- Author
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(0000-0001-9743-2325) Gündel, D., (0000-0003-3168-3062) Deuther-Conrad, W., (0000-0001-9166-2269) Ueberham, L., (0000-0002-1425-0567) Teodoro, R., (0000-0002-0335-7190) Bormans, G., (0000-0002-1136-3857) Toussaint, M., (0000-0003-4267-0603) Hey-Hawkins, E., (0000-0003-4846-1271) Kopka, K., (0000-0001-5555-7058) Brust, P., (0000-0003-3119-7945) Moldovan, R.-P., (0000-0001-9743-2325) Gündel, D., (0000-0003-3168-3062) Deuther-Conrad, W., (0000-0001-9166-2269) Ueberham, L., (0000-0002-1425-0567) Teodoro, R., (0000-0002-0335-7190) Bormans, G., (0000-0002-1136-3857) Toussaint, M., (0000-0003-4267-0603) Hey-Hawkins, E., (0000-0003-4846-1271) Kopka, K., (0000-0001-5555-7058) Brust, P., and (0000-0003-3119-7945) Moldovan, R.-P.
- Abstract
Aim: Cannabinoid receptor 2 (CB2) expression in healthy brain is very low and the upregulation is associated with inflammation, traumatic brain injury, neurodegeneration and cancer[1]. In view of the increasing interest in CB2-targeted therapies, PET offers an attractive strategy to quantify the availability of CB2 in the diseased brain. To achieve this goal, we developed a number of 18F-labelled CB2 ligands and biologically evaluated them in rodents. Here we present a comparative overview of the obtained results. Methods: Structure-activity-relationships-driven target compound identification, organic synthesis and radiofluorination was performed for compounds of the thiazole ([¹⁸F]JHU94620[2] and [¹⁸F]LUZ5[3]), naphthyridin-2-one ([¹⁸F]LU14[4] and [¹⁸F]LU13[5]) and indole ([¹⁸F]RM365) families. The new radioligands were assessed in vitro by binding experiments using CHO(hCB2) cells and rat spleen homogenates and by autoradiography on cryosections of rodent spleen. Furthermore, the radioligands were examined for their metabolic stability and biodistribution by PET. Furthermore, for selected radioligands the binding to highly expressed hCB2 in a rat model overexpressing hCB2(D80N) in the right striatum (AAV-hCB2)[6] was investigated. Results: The low- to subnanomolar hCB2 affinities of the presented radioligands were demonstrated in vitro by Kd values ranging from 0.4 to 2.9 nM with a hCB2 selectivity against hCB1 of >1000-fold. The highest metabolic stability was observed for [18F]RM365 with 55% and 90% and the lowest for [¹⁸F]JHU94620 with 7% and 36% of the initial fraction in plasma and brain 30 min p.i., respectively. The in vivo experiments confirmed the in vitro autoradiographic results, and showed high uptake for [¹⁸F]JHU94620, but low or non-displaceable uptake for [¹⁸F]LU14, [¹⁸F]LUZ5 and [¹⁸F]RM365 in spleen. Contrary to the low uptake of [¹⁸F]LUZ5 in the brain of naïve Wistar rats, target-specific and displaceable uptake for [¹⁸F]LU14 and [¹⁸F]RM365 was de
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- 2023
41. Development of Carborane-Based Ligands for PET and SPECT Imaging
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Ueberham, L., (0000-0003-3119-7945) Moldovan, R.-P., Deuther-Conrad, W., Gündel, D., Brust, P., Kopka, K., Laube, M., Pietzsch, J., Hey-Hawkins, E., Ueberham, L., (0000-0003-3119-7945) Moldovan, R.-P., Deuther-Conrad, W., Gündel, D., Brust, P., Kopka, K., Laube, M., Pietzsch, J., and Hey-Hawkins, E.
- Abstract
The early detection of diseases like Alzheimer, Parkinson or cancer have gained importance over the last decade, since they are still the cause of death of millions of people worldwide.[1] To screen patients for disease markers, non-invasive imaging techniques like Positron Emission Tomography (PET) and Single-photon Emission Computed Tomography (SPECT) are suitable methods for diagnostics.[2] Radiopharmaceuticals with ligands of high affinity and selectivity towards the targets involved in the maladies, like the cannabinoid receptor type 2 (CB2R) or cyclooxygenase 2 (COX-2) have to be developed. In addition to high affinity and selectivity, other requirements are also high metabolic stability or balanced hydrophobicity.[2,3] The development of such radioligands is a challenge; for example, no CB2R radioligand is available for routine clinical applications so far. To overcome the lack in metabolic stability and increase the selectivity of suitable ligands, closo-dicarbadodecaboranes (carboranes) are employed. The hydrophobic carborane can be introduced as a replacement for phenyl, cyclohexyl or adamantyl groups, to name but a few.[4] A new class of ligands based on (metalla)carboranes for application in PET and SPECT imaging for investigation of CB2R and COX-2 have been synthesized and in part biologically evaluated. These results will be presented and discussed in detail.
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- 2023
42. In vitro Cytostatic Effect on Tumor Cells by Carborane-based Dual Cyclooxygenase-2 and 5-Lipoxygenase Inhibitors
- Author
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Braun, S., Paskas, S., (0000-0003-4916-3794) Laube, M., George, S., Hofmann, B., Lönnecke, P., Steinhilber, D., (0000-0002-1610-1493) Pietzsch, J., Mijatović, S. S., Maksimović-Ivanić, D., Hey-Hawkins, E., Braun, S., Paskas, S., (0000-0003-4916-3794) Laube, M., George, S., Hofmann, B., Lönnecke, P., Steinhilber, D., (0000-0002-1610-1493) Pietzsch, J., Mijatović, S. S., Maksimović-Ivanić, D., and Hey-Hawkins, E.
- Abstract
The selective inhibition of enzymes that catalyze the conversion of arachidonic acid to inflammatory eicosanoids represents a promising approach for cancer therapy. We, therefore, focus on the incorporation of metabolically stable, sterically demanding and hydrophobic carboranes into existing dual cycloxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors that are key enzymes in the biosynthesis of eicosanoids. Here, we present the first carborane-containing dual COX-2/5-LO inhibitors derived from RWJ-63556. The replacement of the fluorophenyl moiety by meta- or para-carborane resulted in five carborane-containing derivatives 3, 6, 9, 13 and 17 that show high inhibitory activities toward COX-2 and 5-LO in vitro. Cell viability studies on the A375 melanoma cell line revealed that meta-carborane derivative 3 shows higher anticancer activity compared to RWJ-63556 based on accumulation of lipid droplets in the cells due to blockage of the COX-2 and 5-LO pathways, indicating a promising approach for the design of potent dual COX-2/5-LO inhibitors.
- Published
- 2023
43. Carborane Analogues of Fenoprofen Exhibit Improved Antitumor Activity
- Author
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Useini, L., Mojić, M., (0000-0003-4916-3794) Laube, M., Lönnecke, P., Mijatović, S. S., Maksimović-Ivanić, D., (0000-0002-1610-1493) Pietzsch, J., Hey-Hawkins, E., Useini, L., Mojić, M., (0000-0003-4916-3794) Laube, M., Lönnecke, P., Mijatović, S. S., Maksimović-Ivanić, D., (0000-0002-1610-1493) Pietzsch, J., and Hey-Hawkins, E.
- Abstract
Fenoprofen is a widely used nonsteroidal anti-inflammatory drug (NSAID) against rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis and gout. Like other NSAIDs, fenoprofen inhibits the synthesis of prostaglandins by blocking both cyclooxygenase (COX) isoforms, COX-1 the “house-keeping” enzyme and COX-2 the induced isoform from pathological stimuli. Unselective inhibition of both COX isoforms results in many side effects, but off-target effects have also been reported. The steric modifications of the drugs could afford the desired COX-2 selectivity. Furthermore, NSAIDs have shown promising cytotoxic properties. The structural modification of fenoprofen using bulky dicarba-closo-dodecaborane(12) (carborane) clusters and the biological evaluation of the carborane analogues for COX inhibition and antitumor potential showed that the carborane analogues exhibit stronger antitumor potential compared to their respective aryl-based compounds.
- Published
- 2023
44. Isonimesulide and its carborane analogues as isoform-selective COX inhibitors and antitumor agents
- Author
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Useini, L., Komazec, T., (0000-0003-4916-3794) Laube, M., Lönnecke, P., Schädlich, J., Mijatović, S., Maksimović-Ivanić, D., (0000-0002-1610-1493) Pietzsch, J., Hey-Hawkins, E., Useini, L., Komazec, T., (0000-0003-4916-3794) Laube, M., Lönnecke, P., Schädlich, J., Mijatović, S., Maksimović-Ivanić, D., (0000-0002-1610-1493) Pietzsch, J., and Hey-Hawkins, E.
- Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used therapeutics against pain, fever and inflammation; additionally, antitumor properties have been reported. NSAIDs reduce the synthesis of prostaglandins (PG) by inhibiting the cyclooxygenase (COX) isoforms COX-1 and COX-2. As non-selective inhibition is associated with off-target effects, strategies to achieve selectivity for the clinically preferred isoform COX-2 are of high interest. The modification of NSAIDs using carborane clusters as phenyl mimetics has been reported to alter the selectivity profile through size exclusion. Inspired by these findings, we have prepared isonimesulide and its carborane derivatives. The biological screening showed that the carborane containing compounds exhibit a stronger antitumor potential compared to nimesulide and isonimesulide. Furthermore, the replacement of the phenyl ring of isonimesulide with a carborane moiety resulted in a shift of the COX activity from non-active to COX-active compounds.
- Published
- 2023
45. Synthesis and In Vitro Biological Evaluation of p-Carborane-based Di-tert-butylphenol Analogs
- Author
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Braun, S., Jelača, S., (0000-0003-4916-3794) Laube, M., George, S., Hofmann, B., Lönnecke, P., Steinhilber, D., (0000-0002-1610-1493) Pietzsch, J., Mijatović, S., Maksimović-Ivanić, D., Hey-Hawkins, E., Braun, S., Jelača, S., (0000-0003-4916-3794) Laube, M., George, S., Hofmann, B., Lönnecke, P., Steinhilber, D., (0000-0002-1610-1493) Pietzsch, J., Mijatović, S., Maksimović-Ivanić, D., and Hey-Hawkins, E.
- Abstract
Targeting inflammatory mediators and related signaling pathways may offer a rational strategy for the treatment of cancer. The incorporation of metabolically stable, sterically demanding, and hydrophobic carboranes in dual cycloxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors that are key enzymes in the biosynthesis of eicosanoids is a promising approach. The di-tert-butylphenol derivatives R-830, S-2474, KME-4, and E-5110 represent potent dual COX-2/5-LO inhibitors. The incorporation of p-carborane and further substitution of the p-position resulted in four carborane-based di-tert-butylphenol analogs that show no or weak COX inhibition but high 5-LO inhibitory activities in vitro. Cell viability studies on five human cancer cell lines revealed that the p-carborane analogs R-830-Cb, S-2474-Cb, KME-4-Cb, and E-5110-Cb exhibit lower anticancer activity compared to the related di-tert-butylphenols. Inter-estingly, R-830-Cb did not affect the viability of primary cells and suppressed HCT116 cell pro-liferation more potently than its carbon-based R-830 counterpart. Considering all the ad-vantages of boron cluster incorporation for enhancement of drug biostability, selectivity, and availability of drugs, R-830-Cb can be tested in further mechanistic and in vivo studies.
- Published
- 2023
46. Development of the High-Affinity Carborane-Based Cannabinoid Receptor Type 2 PET Ligand [18F]LUZ5-d8
- Author
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Ueberham, L., (0000-0001-9743-2325) Gündel, D., Kellert, M., (0000-0003-3168-3062) Deuther-Conrad, W., (0000-0002-4358-5171) Ludwig, F.-A., Lönnecke, P., Kazimir, A., (0000-0003-4846-1271) Kopka, K., (0000-0001-5555-7058) Brust, P., (0000-0003-3119-7945) Moldovan, R.-P., Hey-Hawkins, E., Ueberham, L., (0000-0001-9743-2325) Gündel, D., Kellert, M., (0000-0003-3168-3062) Deuther-Conrad, W., (0000-0002-4358-5171) Ludwig, F.-A., Lönnecke, P., Kazimir, A., (0000-0003-4846-1271) Kopka, K., (0000-0001-5555-7058) Brust, P., (0000-0003-3119-7945) Moldovan, R.-P., and Hey-Hawkins, E.
- Abstract
The development of cannabinoid receptor type 2 (CB2R) radioligands for positron emission tomography (PET) imaging was intensively explored. To overcome the low metabolic stability and simultaneously increase the binding affinity of known CB2R radioligands, a carborane moiety was used as a bioisostere. Here we report the synthesis and characterization of carboranebased 1,8-naphthyridinones and thiazoles as novel CB2R ligands. All tested compounds showed low nanomolar CB2R affinity, with (Z)-N-[3-(4-fluorobutyl)-4,5-dimethylthiazole-2(3H)-ylidene]-(1,7-dicarba-closo-dodecaboranyl)-carboxamide (LUZ5) exhibiting the highest affinity (0.8 nM). Compound [18F]LUZ5-d8 was obtained with an automated radiosynthesizer in high radiochemical yield and purity. In vivo evaluation revealed the improved metabolic stability of [18F]LUZ5-d8 compared to that of [18F]JHU94620. PET experiments in rats revealed high uptake in spleen and low uptake in brain. Thus, the introduction of a carborane moiety is an appropriate tool for modifying literature-known CB2R ligands and gaining access to a new class of high-affinity CB2R ligands, while the in vivo pharmacology still needs to be addressed.
- Published
- 2023
47. Carborane-based Tebufelone Analogs and their Biological Evaluation In Vitro
- Author
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Braun, S., Paskas, S., (0000-0003-4916-3794) Laube, M., George, S., Hofmann, B., Lönnecke, P., Steinhilber, D., (0000-0002-1610-1493) Pietzsch, J., Mijatović, S., Maksimović-Ivanić, D., Hey-Hawkins, E., Braun, S., Paskas, S., (0000-0003-4916-3794) Laube, M., George, S., Hofmann, B., Lönnecke, P., Steinhilber, D., (0000-0002-1610-1493) Pietzsch, J., Mijatović, S., Maksimović-Ivanić, D., and Hey-Hawkins, E.
- Abstract
The presence of inflammatory mediators in the tumor microenvironment, such as cytokines, growth factors or eicosanoids, indicate cancer-related inflammatory processes. Targeting these inflammatory mediators and related signal pathways may offer a rational strategy for the treatment of cancer. This study focuses on the incorporation of metabolically stable, sterically demanding, and hydrophobic dicarba-closo-dodecaboranes (carboranes) into dual cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors that are key enzymes in the biosynthesis of eicosanoids. The di-tert-butylphenol derivative tebufelone represents a selective dual COX-2/5-LO inhibitor. The incorporation of meta- or para-carborane into the tebufelone scaffold resulted in eight carborane-based tebufelone analogs that show no COX inhibition but 5-LO inhibitory activities in vitro. Cell viability studies on HT29 colon adenocarcinoma cells revealed that the para-carborane analog 8 exhibits higher anticancer activity compared to tebufelone through the inhibition of cell proliferation. Hence, this strategy proved to be a promising approach to design potent 5-LO inhibitors with potential application as cytostatic agents.
- Published
- 2023
48. Erratum to: Copper(II) Complexes with N,O-Hybrid Ligands Based on Pyridyl-Containing Phospholane Oxides
- Author
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Trigulova, K. R., Shamsieva, A. V., Fayzullin, R. R., Lönnecke, P., Hey-Hawkins, E., Voloshina, A. D., Musina, E. I., and Karasik, A. A.
- Published
- 2020
- Full Text
- View/download PDF
49. OPS-γδ: allogeneic opsonin-secreting γδT cell immunotherapy for solid tumours mediates direct and bystander immunity
- Author
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Fowler, D, primary, Barisa, M, additional, Southern, A, additional, Nattress, C, additional, Hawkins, E, additional, Vassalou, E, additional, Kanouta, A, additional, Counsell, J, additional, Rota, E, additional, Vlckova, P, additional, Draper, B, additional, Tape, C, additional, Chester, K, additional, Anderson, J, additional, and Fisher, J, additional
- Published
- 2022
- Full Text
- View/download PDF
50. The Statistical DownScaling Model − Decision Centric (SDSM-DC) : conceptual basis and applications
- Author
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Wilby, R. L., Dawson, C. W., Murphy, C., O'Connor, P., and Hawkins, E.
- Published
- 2014
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