226 results on '"Hawkins, Christine J."'
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2. Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2
3. Reconstitution of human pyroptotic cell death in Saccharomyces cerevisiae
4. The smac mimetic LCL161 targets established pulmonary osteosarcoma metastases in mice
5. Smac mimetics can provoke lytic cell death that is neither apoptotic nor necroptotic
6. Tetrazolium reduction assays under-report cell death provoked by clinically relevant concentrations of proteasome inhibitors
7. Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis
8. Proteasome inhibitors trigger mutations via activation of caspases and CAD, but mutagenesis provoked by the HDAC inhibitors vorinostat and romidepsin is caspase/CAD-independent
9. Apaf-1 and Caspase-9 Accelerate Apoptosis, but Do Not Determine Whether Factor-Deprived or Drug-Treated Cells Die
10. The Anti-Apoptotic Activity of XIAP Is Retained upon Mutation of Both the Caspase 3- and Caspase 9-Interacting Sites
11. In vitro analysis reveals necroptotic signaling does not provoke DNA damage or HPRT mutations
12. DIABLO Promotes Apoptosis by Removing MIHA/XIAP from Processed Caspase 9
13. A Cloning Method to Identify Caspases and Their Regulators in Yeast: Identification of Drosophila IAP1 as an Inhibitor of the Drosophila Caspase DCP-1
14. Inhibition of Interleukin 1β -converting Enzyme-Mediated Apoptosis of Mammalian Cells by Baculovirus IAP
15. Cloning and Expression of Apoptosis Inhibitory Protein Homologs that Function to Inhibit Apoptosis and/or Bind Tumor Necrosis Factor Receptor-Associated Factors
16. The N Terminus of the Vaccinia Virus Protein F1L Is an Intrinsically Unstructured Region That Is Not Involved in Apoptosis Regulation
17. TRAIL causes deletions at the HPRT and TK1 loci of clonogenically competent cells
18. Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice
19. Inhibition of Bcl-2 or IAP proteins does not provoke mutations in surviving cells
20. Mutagenic assessment of chemotherapy and Smac mimetic drugs in cells with defective DNA damage response pathways
21. Caspases; Modulators of Apoptosis and Cytokine Maturation — Targets for Novel Therapies
22. SfDronc, an initiator caspase involved in apoptosis in the fall armyworm Spodoptera frugiperda
23. Apoptosis Is Triggered When Prosurvival Bcl-2 Proteins Cannot Restrain Bax
24. TWEAK-FN14 Signaling Induces Lysosomal Degradation of a cIAP1-TRAF2 Complex to Sensitize Tumor Cells to TNFα
25. Recent and Ongoing Research into Metastatic Osteosarcoma Treatments
26. Modeling Metazoan Apoptotic Pathways in Yeast
27. Caspase-8 Cleaves Histone Deacetylase 7 and Abolishes Its Transcription Repressor Function
28. Analysis of the minimal specificity of CED-3 using a yeast transcriptional reporter system
29. Caspase-2: controversial killer or checkpoint controller?
30. Mutagenic Consequences of Sublethal Cell Death Signaling
31. Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine
32. Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells
33. Direct inhibition of caspase 3 is dispensable for the anti‐apoptotic activity of XIAP
34. Establishment and Characterisation of Metastatic Extraskeletal Ewing Sarcoma Mouse Models
35. Plexin B2 Is a Regulator of Monocyte Apoptotic Cell Disassembly
36. Transient NK Cell Depletion Facilitates Pulmonary Osteosarcoma Metastases After Intravenous Inoculation in Athymic Mice
37. The Proteasome Inhibitor Ixazomib Inhibits the Formation and Growth of Pulmonary and Abdominal Osteosarcoma Metastases in Mice
38. TRAIL and Malignant Glioma
39. Hsp72 Inhibits Apoptosis Upstream of the Mitochondria and Not through Interactions with Apaf-1
40. Mammalian initiator apoptotic caspases
41. Caspase 8 is absent or low in many ex vivo gliomas
42. Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7
43. Monitoring Activity of Caspases and Their Regulators in Yeast Saccharomyces cerevisiae
44. CrmA orthologs from diverse poxviruses potently inhibit caspases-1 and -8, yet cleavage site mutagenesis frequently produces caspase-1-specific variants
45. The Drosophila Caspase DRONC Cleaves following Glutamate or Aspartate and Is Regulated by DIAP1, HID, and GRIM
46. The Drosophila Caspase Inhibitor DIAP1 Is Essential for Cell Survival and Is Negatively Regulated by HID
47. Vaccinia Virus Encodes a Novel Inhibitor of Apoptosis That Associates with the Apoptosome
48. IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα
49. Data on the DNA damaging and mutagenic potential of the BH3-mimetics ABT-263/Navitoclax and TW-37
50. Caspases; Modulators of Apoptosis and Cytokine Maturation — Targets for Novel Therapies
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