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Objective: Although connexins are thought to provide normally functioning gap junctions via a tumor suppressor gene, new studies point to an abnormal increase of connexins in various carcinomas and sarcomas. Therefore it was aimed to investigate the expression of connexin 43 (Cx43) and connexin 32 (Cx32) in adenomatous and hyperplastic polyps. Materials and Methods: This retrospective study included 32 cases with adenomatous polyps and 42 cases with hyperplastic polyps, between 2014 and 2015. The samples were stained with immunohistochemical staining method with Cx43 and Cx32 and evaluated. Results: In our study, we observed that Cx43 and Cx32 staining increased in hyperplastic polyps compared to adenomatous polyps (p=0.039, p=0.048 respectively). Statistically, there were no significant correlations between age, sex, location, and diameter with staining pattern.Conclusion: Loss of Cx43 and Cx32 staining in adenomatous polyps was noted and thought to be related to dysplasia., Amaç: Konneksinlerin tümör baskılayıcı bir gen yoluyla normal işleyen geçit bağlantıları sağladığı düşünülse de yeni çalışmalar çeşitli karsinom ve sarkomlarda konneksinlerin anormal artışına işaret etmektedir. Bu nedenle adenomatöz ve hiperplastik poliplerde connexin 43 (Cx43) ve connexin 32 (Cx32) ekspresyonunun araştırılması amaçlandı.Materyal ve Metot: Bu retrospektif çalışmaya 2014-2015 yılları arasında adenomatöz polipli 32 olgu ve hiperplastik polipli 42 olgu dahil edildi. Örnekler Cx43 ve Cx32 ile immünohistokimyasal boyama yöntemi ile boyandı ve değerlendirildi.Bulgular: Çalışmamızda, hiperplastik poliplerde adenomatöz poliplere göre Cx43 ve Cx32 boyanmalarının arttığını gözlemledik (sırasıyla p=0,039, p=0,048). İstatistiksel olarak yaş, cinsiyet, yerleşim yeri ve çap ile boyama paterni arasında anlamlı bir ilişki yoktu.Sonuç: Adenomatöz poliplerde Cx43 ve Cx32 boyanmasının azaldığı ve bu durumun displazi ile ilişkili olduğu düşünüldü.

Aim:It is known that muscle mass decreases with age. Sometimes it may be possible to adversely affect this reduction. It was aimed to investigate the contribution of claudin-5 and E-cadherin to this process.Methods:Samples were taken from the psoas muscle of 55 cases autopsied for different reasons between 2018-2019. Age, gender, weight, height, chronic disease, and addiction were recorded. Histopathological degeneration parameters were evaluated. In addition, samples were prepared for immunohistochemical study. Evaluation for E-cadherin and claudin-5; no staining, weak staining, moderate staining and severe staining. Fibrosis was evaluated with Masson trichrome.Results:There was a very strong and statistically significant inverse relationship between acidophilic sarcoplasma and staining with claudin-5 (p0.05).Conclusion:Claudin-5 can be a target protein that can be used in the detection and prophylaxis of degeneration and atrophy in striated muscles.

Uterine perivascular epithelioid cell tumor is a rare mesenchymal tumor consisting of histologically and immunohistochemically distinctive perivascular epithelioid cells. These tumors’ being rare, having different morphological features and having similar immunohistochemical expression findings to that of some tumors lead to diagnostic difficulties and misdiagnoses. In the present case report, we aimed to discuss the traps we fell into while diagnosing the curettage material as neuroendocrine tumor and how we have been directed to the diagnosis of perivascular epithelioid cell tumor, as well as to discuss what to be taken into account while making the differential diagnosis under the guidance of the literature.

Water clear cells; they can be seen in many tumors such as germ cell tumors, kidney tumors, lymphomas, sarcomas, thymic carcinomas, parathyroid carcinomas, paraganglioma. They may be primary or may occur as a result of metastatic conditions. Therefore, histopathologically differential diagnosis may be difficult or confusing. Clinical findings, radiological findings and histopathological evaluation may be required for differential diagnosis. Here, as immunohistochemically; a case with parathormone, CD10 positive and synaptophysin negative and CD10 positivity in the area where clear cells are dominant is presented. The case was reported as water clear cell (WCC) component dominant parathyroid adenoma with clinical, biochemical, radiological evaluation and histopathology and the differential diagnosis is discussed.

The perception of a teacher with regards to a child’s participation and their practices affect his/her participation in educational institutions. To provide effective participation, teacher’s awareness and attitudes towards participation must be examined. This research aims to determine the views of Turkish pre-school and elementary teachers on children’s participation in educational institutions. The participants of the study were comprised of 16 teachers employed in public preschools and elementary schools in a province in Turkey’s Inner Aegean Region. The teachers’ interview form is used as the data collection tool in this study. As a result of the research, it was determined that teachers had a positive perspective on children’s participation, they allow for certain conditions to enable participation coupled with decision-making processes in a limited fashion. Furthermore, it was concluded that teachers had methodical difficulties in decision-making and they thought that they needed to improve themselves in promoting participation. Teachers also thought that the teacher, peer relations, and family are effective on the participation.&nbsp

Background. Systemic oxidative stress may cause detrimental consequences for the liver, leading to hepatic fibrogenesis. Objectives. To investigate histopathological changes in liver tissues due to the increased systemic oxidative stress associated with rat extracorporeal shock wave lithotripsy (SWL) model and to document the consequences of N-acetylcysteine (NAC) administration. Material and methods. In this experimental SWL model, 18 Wistar albino rats were randomly assigned into 3 groups. The control group (group I) had no intervention. Group II underwent SWL treatment with intraperitonea I saline injection. Group III also had SWL with intra peritoneal NAC and was divided into short-term (group III-14 days) and long-term (group III-28 days) subgroup. Hepatectomy was performed for histopathological examinations. Histopathological alterations were evaluated with light microscopy. Immunohistological staining for p53 and myeloperoxidase was also performed. Results. Blood samples revealed a significant increase in plasma oxidative stress index (OSI) after plasma total antioxidant status (TAS) and total oxidant status (TOS) had been measured. It was shown that this increased systemic oxidative stress adversely affected liver tissues. Predominantly, sinusoidal dilatation was remarkably observed in rats with significantly high 051 values (p = 0.043). Similarly, periportal necrosis significantly increased in rats with high OSI values (p = 0.033). p53 positivity was also remarkable in rats with systemic oxidative stress (p = 0.049). N-acetylcysteine administration provided a significant decrease in OSI. N-acetylcysteine also improved all these alterations, including p53 staining. Particularly, sinusoidal dilatation was significantly protected in the long-term NAC group (group III-28 days). Conclusions. We demonstrated that SWL-induced systemic oxidative stress causes histological alterations in liver tissues. Increased p53 and myeloperoxidase staining as markers of oxidative damage were also detected. N-acetylcysteine may protect from these histological and ultra-structural alterations related to oxidative stress. WOS:000585073300006 2-s2.0-85094819330 PubMed: 33030315

Amaç: Bu çalışmanın amacı; vücudun bazı bölgelerinde görülen yassı epitel hücreli karsinom vakalarında Ekadherin ve β-katenin düzeylerinin; hastaların yaşı, cinsiyeti, karsinomların yerleşim yeri ve tümör tipine göre değişip değişmediğini ortaya koymaktır. Materyal ve Metot: Retrospektif olarak yapılan bu çalışmanın örneklemini Ordu Üniversitesi Eğitim Araştırma hastanesine müracaat eden ve deride yassı epitel hücreli karsinom tanısı almış olan 53 hastanın numuneleri oluşturdu. Numuneler E-kadherin ve β-katenin yönünden immünohistokimyasal olarak değerlendirildi. Bulgular: Hastaların yaş dağılımları arasında fark tespit edilmedi (p>0,05). β-katenin ve E- kadherin skorları; cinsiyet ve numunenin alındığı yerleşim yerine göre değişmemektedir (p değerleri sırasıyla; 0,129, 0,106 ve 0,259, 0,120). Tümör tipine göre ise β-katenin skorlarının değişmediği fakat E- kadherin skorlarının önemli oranda değiştiği belirlendi (sırasıyla p değeri; 0,721, 0,013). Sonuç: E-kadherin boyama şiddetinin patolojik tanı tipine göre değiştiği belirlendi. Örneklem genişliği büyütülerek yapılacak bilimsel çalışmalar sonuca önemli katkı sağlayacaktır.

OBJECTIVES This study aims to evaluate the effect of tranexamic acid (TXA) application in tendon healing by using its immunohistochemical effects on tumor necrosis factor-alpha (TNF-α), matrix metalloproteinase-3 (MMP-3), and transforming growth factor-beta (TGF-β) expression; and to identify if TNF-α, MMP-3, and TGF-β can be used to monitor and evaluate tendon healing or not in tenotomized rat Achilles tendons. MATERIALS AND METHODS Twelve male Wistar-Albino rats (age 6-7-month-old; weighing 300-350 g) were used in this retrospective study conducted between November 2016 and May 2017. The rats were divided into two groups with similar weights. The right legs of the rats were determined as the study group (TXA), and the left legs as the control serum physiologic (SP) group. Under anesthesia, bilateral Achilles tenotomy was performed and surgically repaired. 1 mL of TXA was applied locally for the right side and 1 mL of SP was locally applied for the left side. Half of the rats were sacrificed at the third week (right leg-TXA3, left leg-SP3) and the other half at sixth week (right leg-TXA6, left leg-SP6) and tendon samples were taken from the extremities. Immunohistochemical findings of TNF-α, MMP-3, and TGF-β were evaluated on the basis of the frequency and intensity of staining. RESULTS In TNF-α and MMP-3 and TXA groups, there was a significant difference in staining compared to SP groups (p

Objective: Mutations in genes encoding proteins along the RAS-RAF-MEK-ERK pathway have been detected in a variety of tumor entities, including malignant melanoma, thyroid, colon, over carcinomas and some sarcomas. The increased activity of BRAF V600E leads to downward signalization activation via mitogen-activated protein kinase (MAPK), which plays an important role as cell growth, differentiation and survival regulator. Latest data show BRAF undergoes mutation in nearly 7% of cancers and this situation makes BRAF another important oncogene in this pathway. We aimed to evaluate the relationship between keratacanthoma and BRAF expression.Methods: 28 cases of keratocanthomas were included in this study. Sections were taken from the selected blocks with a thickness of 3 microns with poly-lysine coating. BRAF antibody was applied to the tissues. The obtained preparations were evaluated by light microscopy. It was rated according to the degree of staining in epidermis.Results: Areas showing cytoplasmic staining with BRAF were evaluated in sections. It was observed that there was no staining in the keratocanthomas, and staining in sebaceous glands and sweat glands in peripheral basal cells. It was also noted that the sweat glands had more stain than the sebaceous glands. The cases included 18 males and 10 females with ages varying from 33 to 85 years. The duration of the lesions was between one month and one year. Lesion dimensions varied from 5 to 70 mm, with mean size of 21 mm. There were 14 cases (50%) with head and neck localization, and 14 cases (50%) with localization other than the head and neck.Conclusion: As a result, it has been concluded that BRAF mutation may not be involved in keratoacanthoma.

Objective: Via the use of an alternative promoter, a truncated c-KIT protein (tr-KIT) of 30-50 kDa is generated, lacking extracellular and transmembrane domains. Moreover, over-expression of tr-KIT, a stronger activator than c-KIT, appears to be specific to prostate cancer (PCa). Also, Imatinib, a tyrosine kinase inhibitor, blocks the activity of full-length c-KIT but has no effect on tr-KIT in PCa. Tr-KIT has its own nuclear factor binding site. However, the transcription factors (TFs) binding to this region specific to tr-KIT are not known yet. This study was conducted to define the most potential TFs specific for tr-KIT via in silico analysis.Methods: Tr-KIT potential TF binding sequence was uploaded into Tfsitescan database. Five TFs with the highest potential binding to this sequence were selected. Transcriptomic data of LNCaP (PCa expressing tr-KIT), PC3 (PCa not expressing tr-KIT) and RWPE-1 (normal prostate) cell lines (GSM1647378, GSE36022 and GSM738189, respectively) from Gene Expression Omnibus (GEO) database were compared for gene expression levels of pre-defined potential tr-KIT specific TFs using DESeq package of R-program. Finally, two TFs having higher expression levels in both LNCaP and PC3 compared to RWPE-1 and higher expression levels in LNCaP compared to PC3 were detected.Results: Five TFs having the highest potential were selected as: YY1, c-MYB, IL8, NFYA and TCF3. Via in silico analysis performed, it was found that YY1 and NFYA have the highest potential to be tr-KIT specific TFs in PCa, among them.Conclusion: YY1 and NFYA TFs may take a role in formation of tr-KIT in PCa.

Highlights • Superficial Acral Fibromixoma (SAF) is a benign and rare tumor of the soft tissues. • Local recurrence is often associated with a positive margin. • Follow-up is recommended due to the risk of recurrence. • Superficial Acral Fibromixoma, one of the rare myxoid neoplasms should be considered in the differential diagnosis., Introduction Superficial Acral Fibromixoma is a benign and rare tumor of the soft tissues, also it called digital fibromyxoma. It is a painful, slow growing solitary mass that is frequently observed in the fingers, toes and nail beds. Local recurrence is often associated with a positive margin. Presentation of case A 54-year-old male patient had admitted to local state hospital with complaint of a two-lobed mass lesion in the 5th finger of the right hand. The lesion was closely adjacent to the 5th finger flexor tendon. The specimen of the patient undergoing excisional biopsy was sent to our pathology department. Conclusion Superficial Acral Fibromyxoma is one of the rare benign myxoid neoplasms. Its treatment is surgical excision. We reported the case for its rarity and to keep in mind in the acral region neoplasms.

Random flaps are frequently used in the practice of reconstructive surgery. The aim of this experimental study was to investigate the effects of Allium cepa on random flap survival in rats. Fourtee...

One of the simplest form of surgical delay can be performed by placing an incision around the flap without undermining, prior to flap elevation. In this study, we have compared the efficiency of different patterns of skin incision to improve flap survival. Twenty-eight animals were used in four groups. Incisional delay was performed prior to flap elevation in the three experiment groups. Complete incision of the three flap edges was performed in the all experiment groups with the exception of an intact skin section on the middle 1/3rd of the bilateral edges in group 1 (bilateral skin edge preserved delay: BSEPD), of a unilateral edge in group 2 (unilateral skin edge preserved delay: USEPD) and of the superior edge in group 3 (superior skin edge preserved delay: SSEPD) without any undermining. Two weeks following the delay procedure, dorsal skin flaps were raised and reinserted back to their place. The results were evaluated with the measurement of necrotic flap area, microangiographic imaging and histological evaluation. The mean percentage of necrotic flap area to whole flap area was 16.94%, 7.54%, 23.34% and 50.6% in the BSEPD, USEPD, SSEPD and control groups, respectively. In selected microangiographic images, vessels were more prominent in the delay groups. The results of the study indicate that three sided incision with an intact skin on the superior edge is not effective in providing a sufficient delay and flap survival improvement when compared to incisions with intact skin on the unilateral and bilateral edges.

Amac: Bu arastirmada, cesitli biyokimyasal parametreler ve safra kesesi IGF-1 ekspresyonu arasindaki iliski biyokimyasal ve patolojik yontemlerle incelenmistir. Gerec ve Yontemler: 1 Ocak 2017- 31 Ocak 2018 tarihleri arasinda Ordu Egitim Arastirma Hastanesi’nde kronik kolesistit tanisi alan hastalara ait tibbi kayitlar retrospektif olarak incelendi. Hastalarin cesitli biyokimyasal parametreleri calisildi. Kronik kolesistit nedeniyle opere edilen hastalardan elde edilen kolesistektomi materyalinde immunhistokimyasal yontemle IGF-1 antikoru uygulandi. Bulgular: Patolojik incelemede IGF-1 ekspresyonunun izlendigi gruptaki en belirgin biyokimyasal deger CRP yuksekligi olarak saptandi. Sonuc: Safra kesesi IGF-1 ekspresyonu ve inflamasyon iliskisini dusunduren bu bulgularin farkli yontemlerle dogrulanmasi kronik kolesistit gelisimi ve kolesistit-kanser iliskisi uzerine yeni ufuklar acabilir.

Lower extremity pain is frequent in children, and it is usually caused by growth pain. Besides this, a variety of situations including infections, inflammation, trauma and also malignancies can result in swelling, pain, or restriction of movement in the knee during childhood period. When we faced with knee swelling especially in a boy, it is absolutely necessary to take a detailed history of the patient and careful physical examination must be done. Here, a 15-year-old case is presented with complaints of pain and swelling in the knee region.This case received accurate diagnosis and treatment through radiologic and pathologic cooperation after clinical examination.

Objective: Research in recent years focused on the role of the apelin-APJ axis in pathologic fibrosis. The axis includes the parenchyma and mesenchymal cells of most organs. Reduction in parenchymal cells and activation of fibroblasts generally results in fibrosis of the organ. In this study, the aim was to reveal differences in apelin in tendons with primary repair.Methods: The study used 15 male Wistar Albino rats. The tendons of the right and left legs of the rats were used. Rats were divided into 3 groups containing 5 rats each. Group 1 was the sham group; Group 2 had tendon repair performed and were sacrificed 3 weeks later; and Group 3 had tendon repair and were sacrificed 6 weeks later. Under anesthesia, bilateral tendonectomy was performed and surgically repaired. Tendons were removed in the 3rd and 6th weeks. Samples were immunohistochemically stained for apelin and stain degree was assessed from 0 to 4 with a light microscope. The scores were compared with the Friedman test.Results: The results of statistical evaluation identified that the sham group had statistically significantly higher levels compared to the scores in the other two groups. There was no significant difference identified between the groups sacrificed in the 3rd and 6th weeks.Conclusion: This study concluded that apelin may be beneficial for tendon healing and that apelin levels may increase with fibrosis.

Tam Metin / Full Text The aim of this study is to investigate the contribution of the p16 immunohistochemical marker in the cervical intraepithelial neoplasia (CIN) cases in the distinctionbetween CIN1, CIN2, CIN3 and the relationship of CINs with age, localization. CIN1, CIN2, CIN3 preparations of 2015 in the pathology department were retrospectivelyanalyzed. New sections of 3 μm thickness were obtained on polylysine slides from paraffin blocks of these tissues. Samples with immunohistochemical staining with p16were evaluated under a light microscope.p16 expression was semiquantitatively assessed according to staining intensity with 4 staining levels as score 0,1,2,3. As a resultof the Kruskal-Wallis test, a significant difference was found between the scores in the CIN groups (p 0.05). The variations between CIN groups andanatomical locations on the cervix were examined with Chi-square test. There was no change in the frequency distribution of CIN groups in the anatomical locations onthe cervix (p> 0.05). In cervical intraepithelial neoplasms, p16 was found to show increased staining with the severity of the lesion. It was observed that p16 expression isimportant in CIN evaluation and reduces

This study aims to evaluate the behavioral engagement levels of elementary school students in Turkey and to determine the factors affecting the behavioral engagement levels of students in line with the views of elementary school teachers. Participants of the quantitative stage are selected by the random sampling method, from 50 students each from 1st, 2nd, 3rd, and 4th grades and 200 in total that attend to an elementary school in Turkey's inner Aegean region directed by the Ministry of Education. The participants of the study concerning the qualitative stage were 10 elementary school teachers. It was determined that elementary school students have a medium behavioral engagement level, and the gender variable is effective on engagement levels. It has been determined that elementary school teachers have awareness about engagement indicators and teachers think that the interaction they establish with students and the methods they use in the lessons affect the engagement.

Öğretmen adaylarının çocuk katılımına ilişkin olumlu bakış açısına sahip olmaları, ileriki meslek yaşamlarında katılım hakkını gerçekleştirme biçimlerini ve uygulamaların niteliğini etkileyecektir. Bu çalışmanın amacı, okul öncesi ve sınıf öğretmen adaylarının eğitim kurumlarında çocuk katılımına yönelik görüşlerinin belirlenmesidir. Araştırmada nitel araştırma yöntemlerinden fenomenolojik yaklaşım kullanılmıştır. Araştırmanın çalışma grubunu, Türkiye’nin iç ege bölgesindeki bir üniversitenin okul öncesi eğitimi ve sınıf eğitimi bölümlerinin son sınıfta öğrenim görmekte olan 8’i okul öncesi, 8’i sınıf öğretmen adayı olmak üzere toplam 16 öğretmen adayı oluşturmuştur. Araştırmada veri toplama aracı olarak, araştırmacılar tarafından hazırlanan “Öğretmen Adaylarının Çocuk Katılımına Yönelik Görüşme Formu” kullanılmıştır. Araştırmadan elde edilen verilerin analizinde içerik analizi kullanılmıştır. Araştırmadan elde edilen veriler, dört tema çocuğun okulda katılımı, sınıfta alınan kararlar, görüşlerin ifade edilme süreci ve öğretmenlik uygulamasındaki deneyimler olmak üzere toplam dört tema altında toplanmıştır. Bu araştırma sonucunda okul öncesi ve sınıf öğretmen adaylarının katılıma yönelik olumlu bir bakış açısına sahip oldukları, katılımı sağlamaya yönelik uygulamalar konusunda deneyim kazanmak istedikleri belirlenmiştir. Öğretmen adayları, öğretmenlik deneyimleri sırasında çocukların görüşlerini soru-cevap yöntemi ile almaya çalıştıklarını belirtmişlerdir. Ayrıca bu araştırmaya katılan öğretmen adaylarının çocuk katılımını sağlamada aile ve öğretmenin önemli olduğunu ve ileriki meslek yaşamlarında katılım süreçlerine yer vermeyi düşündükleri görülmüştür. Öğretmen adaylarının çocuk katılımı ile ilgili bilgi ve deneyimlerinin yetersiz olduğu göz önünde bulundurularak temel eğitim bölümü ders programlarına çocuk katılımı üzerine zorunlu ya da seçmeli dersler eklenebilir. Çocuk katılımının önemi ve rolü ile ilgili yönelik farkındalığın artırılması için temel eğitim bölümü öğrencilerine yönelik, seminerler gerçekleştirilebilir ve öğrenci kulüplerinde farklı uzmanlar tarafından çocuk katılımına yönelik projelerin gerçekleştirilmesine rehberlik edilebilir., Prospective teachers' positive attitude towards child participation will affect the way they realize the right to participate in their future professional life and the quality of their practices. The aim of this study is to determine the opinions of pre-school and classroom teacher candidates about child participation in school. Qualitative research methods in this research study group used the phenomenological approach, Turkey's domestic pre-school to university in the Aegean education and is studying in the final year of classroom training section 8 of the pre-school has a total of 16 teachers, including 8 primary teacher candidates . In the research, as a data collection tool, "Interview Form for Teacher Candidates for Child Participation" prepared by the researchers was used. Content analysis was used and the data obtained from the research were gathered under four themes in total: the participation of the children at school, the decisions made in the classroom, the process of expressing opinions, and the teaching practice. As a result of this research, it was determined that teacher candidates have a positive viewpoint towards participation, and their knowledge and experience on participation is limited. The preservice teachers stated that they tried to get the opinions of the children by question and answer method during their teaching experiences. In addition, it was observed that the teacher candidates participating in this study thought that the family and the teacher are important in ensuring child participation and they consider including participation processes in their future professional lives. Compulsory or elective courses on child participation can be added to the curriculum of the basic education department. In order to raise awareness about the importance of child participation, seminars can be organized for teacher candidates and various specialists in student clubs can be guided in the realization of projects for child participation.Keywords: Phenomenological Approach, Participation, Participation Right, Preschool Teacher Candidate, Primary School Teacher Candidate.

Amaç: ADAM TS proteinleri, transmembran glikoproteinlerdir.ADAMTS ailesindeki proteazlarda disregülasyon veya fonksiyonel değişiklikler, polikistik over sendromu (PCOS) ve prematür over yetmezliği (POF) gibi üreme bozukluklarıyla ilişkilendirilmiştir. Bu çalışmada; follikül epitelinde ADAMTS 16 ekspresyonunun FSH ve LH ile ilişkisinin irdelenmesi amaçlanmıştır.Gereç ve Yöntem: Çalışmaya 2013-2015 yılları arasında ooferektomi geçirmiş olan ve alınan doku örnekleri patoloji bölümüne gönderilen, yaş aralığı 18-55 yıl olan toplam 78 vaka dahil edildi. Vakalara ait parafin bloklardan polilizinli lam üzerine, 3 mikrometre kalınlığında kesitler alındı. Bu kesitlere ABC tekniği ile imuunohistokimyasal olarak FSH, LH ve ADAMTS-16 uygulandı. Işık mikroskobu altında boyanma değerlenrilirken; yok:0,hafif boyanma:1, orta:2, şiddetli:3 olarak derecelendirildi. Çalışmada hastalardan alınan örnekler üzerinde yapılan patolojik inceleme sonrasında yapılan LH, FSH, ADAM TS -16 boyanma sonuçlarının (Yok, Var) birbirleriyle ve hastaların yaşı ile arasındaki bağımlılık yapısını incelemek amacı ile ki-kare analizi kullanılmıştır. Tüm istatistiksel hesaplamalar SPSS 19.0 V istatistik paket programında yapılmış olup bulgular n ve yüzde olarak ifade edilmiştir.Bulgular: Hastalardan alınan örnekler üzerinde yapılan patolojik inceleme sonrasında yapılan LH, FSH ve ADAMTS -16 boyanma sonuçlarının hastaların yaşına göre değişmediği belirlenmiştir (sırasıyla; P=0.215, P=0.665 ve P=0.508).Hastalardan alınan örnekler üzerinde yapılan patolojik inceleme sonrasında yapılan LH boyanma sonuçlarının FSH boyanma sonuçlarına bağlı olarak değiştiği (P 0.05).Conclusion: A new perspective on the roles of ADAMTS; It will provide a deeper understanding of the molecular mechanisms behind fertility and the development of biological markers that predict dysfunction of the reproductive organs.

Objective: We aimed to evaluate and compare the effects of anti-adhesion materials,Seprafilm, Suprofilm, olive oil, and olive oil containing Vitamin E by measuring tensionforces.Methods: 60 male Wistar-Albino rats were divided into six groups. The front side of thececum and right abdominal parietal peritoneal wall were abrased. The rats wereeuthanized on the 14th postoperative day. Adhesions between intestines, omentum, otherabdominal organs, cecum, incisionsites, and abdominal anterior wall peritoneum were allevaluated. Adhesion strength was measured with dynamometer. Histopathologicalevaluations of the adhesion area was performed.Results: Stage-I (0.43Newton) in Group-I, stage-IV (1.0540N) in Group-II, stage-II(0.6370N) in Group-III, stage-II in Group-IV (0, 5230N), stage-III (0.7620N) in Group-V,stage-IV (1.3560N) in Group-VI, were detected. A significant difference was foundbetween these findings. P = 0.001, (p

Piyodermagangrenozum(PG), nedeni tam olarak aydınlatılamamış, nötrofilikdermatozlar grubundan bir hastalıktır. Primer olarak anormal nötrofilkemotaksisininpatogenezde sorumlu olduğu düşünülmektedir. Lezyonlar ağrılı, deriden kabarık, hassas ve ülsere nodüller şeklindedir. PG, birçok hastalıkla birlikte görülebilir. Ancak, PG idiyopatik olarak da görülebilir.Burada atipik yerleşimli olarak sol lateralgluteal bölgede ortaya çıkan büyük, ülsere, etrafı endüre ve eritemli olan, lezyonun yara kenarından alınan biyopside piyodermagangrenosum olarak değerlendirilen vakamızı sunuyoruz., Pyoderma gangrenosum (PG) is a chronic inflammatory skin disease that is present in a group of rare, compromised, neutrophilic dermatoses. It is seen in adult ages, especially ages 25-50. From the lesions that start as painful nodules or pustules, ulcers develop on the edges, which tend to be puffy, tender, and gradually expanding. Lesions may be seen as idiopathic, single or multiple lesions with or without systemic diseases such as malignancy, ulcerative colitis, Crohn's disease, polyarthritis, monoclonal gammopathy. Here we present our case, which is a large, ulcerated, circumscribed, and erythematous lesion located at the left lateral gluteal region as atypically localized, biopside pyoderma gangrenosum taken from the wound side of the lesion.

Amaç: Masthücrelerinin (MCs) rolleri birçok tümörde çeşitli biyolojik süreçlerdegösterilmiştir. MCs, artan anjiyogenez yoluyla tümör progresyonunda rol oynar.Triptaz ve kimaz, mast hücre granüllerinde depolanır. Bu çalışmanın amacı,prostat adenokarsinomalarında (PA) triptaz ve kimaz arasındaki ilişkiyiaraştırmaktır. Gereçve Yöntem: Bu çalışma, 2012-2014 yılları arasında TıpFakültesi Hastanesi Patoloji Bölümü'nde histopatolojik olarak PA tanısı alan134 hastanın parafine gömülü numunesinde yürütülmüştür. Parafine gömülü PAnumuneleri 3 μm kalınlığında kesilmiştir. Kesitler triptaz ve kimaz ile boyanmıştır.Bulgular:MastHücre Kimazının (MCC), intratümöral bölgelerde peritümöral bölgelere göre daha çokbiriktiği gözlenmiştir (sırasıyla ortalama: 14,28 ± 14,06, ortalama: 12,12 ±12,56). Mast Hücre Triptazı (MCT), intratümöral ve peritümöral bölgelerde MCC'dendaha fazla birikmiştir (P, Objective: Theroles of mast cells (MCs) have beendemonstrated in various biologic processes in the many tumors. MCs play someroles in tumor progression via increasing angiogenesis. Tryptase and chymaseare stored in the mast cell granules. The aim of this study was to investigate therelationship of tryptase and chymase inprostatic adenocarcinomas (PA).Materials and Methods: This study was conducted on atotal of 134 paraffin-embedded PAsamples, which were histopathologically diagnosed at the Department ofPathology of medicine Hospital between 2012 and 2014. Paraffin-embedded PA samples 3 μmin thickness, were then cut. The slides were stained with tryptase and chymase.Result: MastCell Chymase (MCC) was observed that intratumoral areas more acumulate thanperitumoral areas (respectively; mean: 14,28 ± 14,06, mean: 12,12 ± 12,56).Mast Cell Tryptase (MCT) was more acumulated than MCC in intratumoral andperitumoral areas (P

Amaç: WT1, ilk olarak Wilms tümörü gelişimini etkileyen tümör baskılayıcı bir gen olarak tespit edilmiş olsa da, kolon kanseri gibi bazı malignitelerde ekspresyonunun arttığı, dolayısıyla onkojenik özelliklerinin olduğu da bildirilmektedir. Bu çalışmanın amacı WT1 ekspresyonunun hastanın yaşına, cinsiyetine, örneğin alındığı bölgeye ve patolojik tanı türüne göre değişip değişmediğini tespit etmektir. Gereç ve Yöntemler: Patoloji anabilim dalına gönderilmiş kolon polipli 32 hastaya ait parafin blokların ve patoloji raporlarının retrospektif histopatolojik değerlendirilmesi yapılmıştır. İstatistiksel olarak p, Aim: Although WT1 was first identified as a tumor suppressor gene affecting Wilms’ tumor development, it has also been reported that its expression increases in certain malignancies such as colon cancer, and that it therefore has oncogenic properties. In this study, we aimed to determine dependence of WT1 expression on patient age and sex, type of pathological diagnosis, and the sample-taking area. Materials and Methods: Paraffin-embedded blocks and pathology reports of 32 patients with colon polyps that had been sent to pathology department were histopathologically reviewed retrospectively. p

Aim: It was aimed to document gastrointestinal system polyps and evaluated with respect to their frequency, size, anatomic location and histopathologic features. Material and Method: 56 gastrointestinal polyps that were histopathologically diagnosed during the period 2014-2015 were included in the study. Polyps were noted according to their localization, age, gender, size and histopathologic types. Results: 59 % of the patients were males and 41% of the patients were females. Their mean age was 61.7 years. The mean diameter of the adenomatous polyps was 10.12 mm. The mean diameter of the hyperplastic polyps was 5.7 mm.18 cases were diagnosed as tubular adenomas(32 %). 16 cases were diagnosed as tubulovillous adenomas (28%), 21 cases were diagnosed as hyperplastic polyps (37.5%), 1 case was diagnosed as mixed polyps,1 case was diagnosed as juvenile polyps. 10 cases of hyperplastic polyps were localized sigmoid colon (% 47.6) and 6 cases were localized rectum (% 28.5). 16 cases of adenomatous polyps were localized sigmoid colon (% 47). Ages ranged from 4 to 84 years were diagnosed as all polyps. Gender were 33 men and 23 female. Conclusion: In this study, it was showed that the oldest groups of tubulovillous adenoma, the most common groups of hyperplastic polyps, the most common gender of male, the most common location of sigmoid colon.

Corneal and conjunctival intraepithelial neoplasia is a slowly progressive ocular surface lesion with low malignant potential. Owing to the high recurrence rates, cryotherapy or topical chemotherapy is used with surgical treatment. In this paper, we report the histopathologic findings and treatment of a case of intraepithelial neoplasia that began in the conjunctiva and progressed to the cornea. A 75-year-old woman presented with complaints of redness, irritation and lacrimation in her left eye for around 1 month. Slit-lamp examination revealed a papilliform mass on the nasal conjunctiva along with involvement of the adjacent corneal epithelium. Conjunctival excisional biopsy showed a moderate epithelial dysplasia. Topical 0.04% mitomycin C was administered 4 times daily for 3 weeks. No recurrence was observed in the following 18 months., Korneal ve konjonktival intraepitelyal neplazi, düşük malignite potansiyeli olan yavaş ilerleyen bir oküler yüzey lezyonudur. Yüksek nüks oranları nedeniyle kriyoterapi veya topikal kemoterapi cerrahi tedavi ile birlikte kullanılmaktadır. Çalışmamızda, konjonktivada başlayıp korneaya ilerleyen intraepitelyal neoplazili olgunun histopatolojik bulgularını ve tedavisini sunduk. Yetmiş beş yaşında kadın hasta yaklaşık 1 aydır devam eden sol gözünde kızarıklık, batma ve sulanma şikayetleri ile kliniğe başvurdu. Biyomikroskobik muayenede; nazal konjonktivada papilliform kitle ve bitişik kornea epitelinde tutulum mevcuttu. Konjonktival eksizyonel biyopsi sonucu orta derecede epitelyal displazi olarak raporlandı. Hastaya günde 4 defa, 3 hafta süresince topikal %0,04 mitomisin C uygulandı. Takip eden 18 aylık sürede nüks gelişmedi.