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19 results on '"Havugimana, Pierre C."'

3. The protein organization of a red blood cell

Author

Sae-Lee, Wisath, primary, McCafferty, Caitlyn L., additional, Verbeke, Eric J., additional, Havugimana, Pierre C., additional, Papoulas, Ophelia, additional, McWhite, Claire D., additional, Houser, John R., additional, Vanuytsel, Kim, additional, Murphy, George J., additional, Drew, Kevin, additional, Emili, Andrew, additional, Taylor, David W., additional, and Marcotte, Edward M., additional

Published
2022
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5. Panorama of ancient metazoan macromolecular complexes

Author

Wan, Cuihong, Borgeson, Blake, Phanse, Sadhna, Tu, Fan, Drew, Kevin, Clark, Greg, Xiong, Xuejian, Kagan, Olga, Kwan, Julian, Bezginov, Alexandr, Chessman, Kyle, Pal, Swati, Cromar, Graham, Papoulas, Ophelia, Ni, Zuyao, Boutz, Daniel R., Stoilova, Snejana, Havugimana, Pierre C., Guo, Xinghua, Malty, Ramy H., Sarov, Mihail, Greenblatt, Jack, Babu, Mohan, Derry, W. Brent, Tillier, Elisabeth R., Wallingford, John B., Parkinson, John, Marcotte, Edward M., and Emili, Andrew

Subjects
Metazoa -- Research, Coordination compounds -- Properties, Cell fractionation -- Analysis, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse metazoan models. Using an integrative approach, we generated a draft conservation map consisting of more than one million putative high-confidence co-complex interactions for species with fully sequenced genomes that encompasses functional modules present broadly across all extant animals. Clustering reveals a spectrum of conservation, ranging from ancient eukaryotic assemblies that have probably served cellular housekeeping roles for at least one billion years, ancestral complexes that have accrued contemporary components, and rarer metazoan innovations linked to multicellularity. We validated these projections by independent co-fractionation experiments in evolutionarily distant species, affinity purification and functional analyses. The comprehensiveness, centrality and modularity of these reconstructed interactomes reflect their fundamental mechanistic importance and adaptive value to animal cell systems., Introduction Elucidating the components, conservation and functions of multiprotein complexes is essential to understand cellular processes (1,2), but mapping physical association networks on a proteome-wide scale is challenging. The development [...]

Published
2015
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6. The protein organization of a red blood cell

Author

Sae-Lee, Wisath, primary, McCafferty, Caitlyn L., additional, Verbeke, Eric J., additional, Havugimana, Pierre C., additional, Papoulas, Ophelia, additional, McWhite, Claire D., additional, Houser, John R., additional, Vanuytsel, Kim, additional, Murphy, George J., additional, Drew, Kevin, additional, Emili, Andrew, additional, Taylor, David W., additional, and Marcotte, Edward M., additional

Published
2021
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9. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain

Author

Pourhaghighi, Reza, primary, Ash, Peter E.A., additional, Phanse, Sadhna, additional, Goebels, Florian, additional, Hu, Lucas Z.M., additional, Chen, Siwei, additional, Zhang, Yingying, additional, Wierbowski, Shayne D., additional, Boudeau, Samantha, additional, Moutaoufik, Mohamed T., additional, Malty, Ramy H., additional, Malolepsza, Edyta, additional, Tsafou, Kalliopi, additional, Nathan, Aparna, additional, Cromar, Graham, additional, Guo, Hongbo, additional, Al Abdullatif, Ali, additional, Apicco, Daniel J., additional, Becker, Lindsay A., additional, Gitler, Aaron D., additional, Pulst, Stefan M., additional, Youssef, Ahmed, additional, Hekman, Ryan, additional, Havugimana, Pierre C., additional, White, Carl A., additional, Blum, Benjamin C., additional, Ratti, Antonia, additional, Bryant, Camron D., additional, Parkinson, John, additional, Lage, Kasper, additional, Babu, Mohan, additional, Yu, Haiyuan, additional, Bader, Gary D., additional, Wolozin, Benjamin, additional, and Emili, Andrew, additional

Published
2020
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11. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes

Author

Phanse, Sadhna, primary, Wan, Cuihong, additional, Borgeson, Blake, additional, Tu, Fan, additional, Drew, Kevin, additional, Clark, Greg, additional, Xiong, Xuejian, additional, Kagan, Olga, additional, Kwan, Julian, additional, Bezginov, Alexandr, additional, Chessman, Kyle, additional, Pal, Swati, additional, Cromar, Graham, additional, Papoulas, Ophelia, additional, Ni, Zuyao, additional, Boutz, Daniel R., additional, Stoilova, Snejana, additional, Havugimana, Pierre C., additional, Guo, Xinghua, additional, Malty, Ramy H., additional, Sarov, Mihail, additional, Greenblatt, Jack, additional, Babu, Mohan, additional, Derry, W. Brent, additional, Tillier, Elisabeth R., additional, Wallingford, John B., additional, Parkinson, John, additional, Marcotte, Edward M., additional, and Emili, Andrew, additional

Published
2016
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13. An informatic framework for decoding protein complexes by top-down mass spectrometry

Author

Skinner, Owen S, primary, Havugimana, Pierre C, additional, Haverland, Nicole A, additional, Fornelli, Luca, additional, Early, Bryan P, additional, Greer, Joseph B, additional, Fellers, Ryan T, additional, Durbin, Kenneth R, additional, Do Vale, Luis H F, additional, Melani, Rafael D, additional, Seckler, Henrique S, additional, Nelp, Micah T, additional, Belov, Mikhail E, additional, Horning, Stevan R, additional, Makarov, Alexander A, additional, LeDuc, Richard D, additional, Bandarian, Vahe, additional, Compton, Philip D, additional, and Kelleher, Neil L, additional

Published
2016
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16. A Census of Human Soluble Protein Complexes

Author

Havugimana, Pierre C., primary, Hart, G. Traver, additional, Nepusz, Tamás, additional, Yang, Haixuan, additional, Turinsky, Andrei L., additional, Li, Zhihua, additional, Wang, Peggy I., additional, Boutz, Daniel R., additional, Fong, Vincent, additional, Phanse, Sadhna, additional, Babu, Mohan, additional, Craig, Stephanie A., additional, Hu, Pingzhao, additional, Wan, Cuihong, additional, Vlasblom, James, additional, Dar, Vaqaar-un-Nisa, additional, Bezginov, Alexandr, additional, Clark, Gregory W., additional, Wu, Gabriel C., additional, Wodak, Shoshana J., additional, Tillier, Elisabeth R.M., additional, Paccanaro, Alberto, additional, Marcotte, Edward M., additional, and Emili, Andrew, additional

Published
2012
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19. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes.

Author

Phanse S, Wan C, Borgeson B, Tu F, Drew K, Clark G, Xiong X, Kagan O, Kwan J, Bezginov A, Chessman K, Pal S, Cromar G, Papoulas O, Ni Z, Boutz DR, Stoilova S, Havugimana PC, Guo X, Malty RH, Sarov M, Greenblatt J, Babu M, Derry WB, Tillier ER, Wallingford JB, Parkinson J, Marcotte EM, and Emili A

Abstract

Our analysis examines the conservation of multiprotein complexes among metazoa through use of high resolution biochemical fractionation and precision mass spectrometry applied to soluble cell extracts from 5 representative model organisms Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Strongylocentrotus purpuratus, and Homo sapiens. The interaction network obtained from the data was validated globally in 4 distant species (Xenopus laevis, Nematostella vectensis, Dictyostelium discoideum, Saccharomyces cerevisiae) and locally by targeted affinity-purification experiments. Here we provide details of our massive set of supporting biochemical fractionation data available via ProteomeXchange (PXD002319-PXD002328), PPIs via BioGRID (185267); and interaction network projections via (http://metazoa.med.utoronto.ca) made fully accessible to allow further exploration. The datasets here are related to the research article on metazoan macromolecular complexes in Nature [1].

Published
2015
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