160 results on '"Haverkamp L"'
Search Results
2. Trends in surgical techniques for the treatment of esophageal and gastroesophageal junction cancer: the 2022 update
- Author
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de Groot, E M, primary, Goense, L, additional, Kingma, B F, additional, Haverkamp, L, additional, Ruurda, J P, additional, and van Hillegersberg, R, additional
- Published
- 2023
- Full Text
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3. Cost-effectiveness of laparoscopic vs open gastrectomy for gastric cancer: an economic evaluation alongside a randomized clinical trial
- Author
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Veen, A. van der, Meulen, M.P. van der, Seesing, M.F.J., Brenkman, H.J.F., Haverkamp, L., Luyer, M.D.P., Nieuwenhuijzen, G.A.P., Stoot, J.H.M.B., Tegels, J.J.W., Wijnhoven, B.P.L., Lagarde, S.M., Steur, W.O. de, Hartgrink, H.H., Kouwenhoven, E.A., Wassenaar, E.B., Draaisma, W.A., Gisbertz, S.S., Peet, D.L. van der, Laarhoven, H.W.M. van, Frederix, G.W.J., Ruurda, J.P., Hillegersberg, R. van, and Laparoscopic Vs Open Gastrectomy G
- Abstract
IMPORTANCE Laparoscopic gastrectomy is rapidly being adopted worldwide as an alternative to open gastrectomy to treat gastric cancer. However, laparoscopic gastrectomy might be more expensive as a result of longer operating times and more expensive surgical materials. To date, the cost-effectiveness of both procedures has not been prospectively evaluated in a randomized clinical trial. OBJECTIVE To evaluate the cost-effectiveness of laparoscopic compared with open gastrectomy. DESIGN, SETTING, AND PARTICIPANTS In this multicenter randomized clinical trial of patients undergoing total or distal gastrectomy in 10 Dutch tertiary referral centers, cost-effectiveness data were collected alongside a multicenter randomized clinical trial on laparoscopic vs open gastrectomy for resectable gastric adenocarcinoma (cT1-4aN0-3bM0). A modified societal perspective and 1-year time horizon were used. Costs were calculated on the individual patient level by using hospital registry data and medical consumption and productivity loss questionnaires. The unit costs of laparoscopic and open gastrectomy were calculated bottom-up. Quality-adjusted life-years (QALYs) were calculated with the EuroQol 5-dimension questionnaire, in which a value of 0 indicates death and 1 indicates perfect health. Missing questionnaire data were imputed with multiple imputation. Bootstrapping was performed to estimate the uncertainty surrounding the cost-effectiveness. The study was conducted from March 17, 2015, to August 20, 2018. Data analyses were performed between September 1, 2020, and November 17, 2021. INTERVENTIONS Laparoscopic vs open gastrectomy. MAIN OUTCOMES AND MEASURES Evaluations in this cost-effectiveness analysis included total costs and QALYs. RESULTS Between 2015 and 2018, 227 patients were included. Mean (SD) age was 67.5 (11.7) years, and 140 were male (61.7%). Unit costs for initial surgery were calculated to be euro8124 (US $8087) for laparoscopic total gastrectomy, euro7353 (US $7320) for laparoscopic distal gastrectomy, euro6584 (US $6554) for open total gastrectomy, and euro5893 (US $5866) for open distal gastrectomy. Mean total costs after 1-year follow-up were euro26 084 (US $25 965) in the laparoscopic group and euro25 332 (US $25 216) in the open group (difference, euro752 [US $749; 3.0%]). Mean (SD) QALY contributions during 1 year were 0.665 (0.298) in the laparoscopic group and 0.686 (0.288) in the open group (difference, -0.021). Bootstrapping showed that these differences between treatment groups were relatively small compared with the uncertainty of the analysis. CONCLUSIONS AND RELEVANCE Although the laparoscopic gastrectomy itself was more expensive, after 1-year follow-up, results suggest that differences in both total costs and effectiveness were limited between laparoscopic and open gastrectomy. These results support centers' choosing, based on their own preference, whether to (de)implement laparoscopic gastrectomy as an alternative to open gastrectomy.
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- 2022
4. Systematic review of the surgical strategies of adenocarcinomas of the gastroesophageal junction
- Author
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Haverkamp, L., Ruurda, J.P., van Leeuwen, M.S., Siersema, P.D., and van Hillegersberg, R.
- Published
- 2014
- Full Text
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5. BJS commission on surgery and perioperative care post-COVID-19
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Abahuje, E, Abbas, A, Abd El Aziz Abd El Maksoud, M, Abdelhady, A, Abdelhamid, S, Abdelkarem Ahmed Faraj, H, Abdelqader, B, Abdelrahman, T, Abdou, H, Abdullah, A, Abedua Harrison, M, Abem Owusu, E, Aboalazayem, A, Aboulhosn, R, Abu Oda, S, Abubakar, A, Abutaka, A, Acevedo Fontalvo, D, Acuna, S, Adefemi, A, Adegbola, S, Adenuga, T, Adeyeye, A, Adil Hilmi, A, Adisa, A, Aditya, K, Adjeso, T, Aftab, R, Afzal, A, Aggarwal, V, Aggarwal, A, Aguilera, R, Aguilera-Arevalo, M, Aguirre Salamanca, E, Aguirre-Allende, I, Ahari, D, Ahmad, H, Ahmad Rauf, F, Ahmad Zartasht Khan, A, Ahmed, S, Ahmed Fieturi, N, Ahmed Mohamed, S, Ahmed-Bakhsh, Z, Ahsan Javed, M, Akano, L, Akbar, A, Akhbari, M, Akhmedov, P, Aksit, G, Akula, Y, Alagaratnam, A, Al Majid, S, Al Mukhtar, O, Al Omran, H, Alasali, N, Al-Azzawi, M, Al-Habsi, R, Al-Iraqi, H, Al-Naggar, H, Alameer, E, Albirnawi, H, Alderson, D, Aldulaijan, F, Alejandro Miranda Ojeda, R, Alhasan, A, Ali, S, Ali, A, Ali Khan, M, Alimova, Y, Aljanadi, F, Aljubure, R, Allopi, N, Almedbal, H, Almubarak, M, Alqaidoom, Z, Alselaim, N, Alshaar, M, Alshammari, R, Altaf, K, Altiner, S, Altunpak, B, Alvarez Lozada, L, Amal Nahal, E, Amer, A, Amin, K, Aminu, U, Amisi Numbi, N, Amjad, T, Amoah, R, An, Y, Anastasopoulos, N, Andres Urrutia, J, Angarita, F, Angarita, K, Angel Freiria Eiras, M, Antypas, A, Anwar, M, Anwar, H, Apampa, T, Apostolou, K, Aquina, C, Arachchige Adithi Himika Randeni, R, Archila Godinez, M, Arez, O, Arezzo, A, Armonis, P, Arshad, S, Arshad Salman, M, Arshid, A, Arteaga Asensio, P, Arthur, T, Arumuga Jothi, A, Aryo Damara, F, Asensio Gomez, L, Ashcroft, J, Ashraf, S, Asif, A, Atif, M, Attaullah Khan, M, Avellaneda, N, Awad, S, Awadh, M, Axiaq, A, Ayad Mohammed Shuwayyah, A, Ayalew, D, Aytac, E, Azam, F, Azevedo, J, Azhar, B, Aziz, J, Aziz, A, Azzam, A, Baba Ndajiwo, A, Baig, M, Baker, D, Bakko, F, Balachandran, R, Balachandran, G, Balagizi Mudekereza, J, Balai, E, Balci, B, Balduzzi, A, Balhareth, A, Bandyopadhyay, S, Banerjee, D, 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Burelli, A, Burke, A, Burke, J, Burlov, N, Burns, A, Burton, O, Butt, A, Buzra Ozkan, B, Cabrera Silva, L, Caicedo, E, Calderbank, T, Cambridge, W, Campelo, G, Can Tatar, O, Carbone, F, Carrano, F, Casallas, D, Casanova Portoles, D, Casciani, F, Cassimjee, I, Castaneda Ramirez, O, Catalan, V, Caviedes, J, Cayetano, L, Ceresoli, M, Chan, M, Chan, V, Chandrasinghe, P, Chapman, S, Chaturvedi, A, Chaudhry, D, Chaudry, H, Chen, H, Cheng, A, Chernykh, M, Cherrie, A, Cheruiyot, I, Cheung, J, Chia, C, Chica, J, Chinai, N, Chirwa, A, Chiwaligo, J, Choi, A, Choi, J, Chowdhury, M, Christopher, E, Christou, N, Chu, T, Chua, D, Chua, H, Chung, C, Cihat Yildirim, A, Cillo, M, Cioffi, S, Claireaux, H, Clermonts, S, Clifford, R, Climent, M, Clynch, A, Coelen, R, Colas-Ruiz, E, Collar, A, Collard, M, Conlon, K, Connelly, T, Connor, K, Cook, J, Correia De Sa, T, Cosgun Acar, N, Costa, T, Couch, D, Cowper, S, Creavin, B, Crook, B, Curell, A, D'Alessio, R, Dale, J, Damgaard Eriksen, J, Dario Martin 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A., MinHua Zheng Z., Mischlinger H., Mockli B., Modi R., Mohamed H. M., Mohamed M., Mohamed Abulghasm T., Mohammad S. A., Mohammed T. O., Mohammed A., Mohan H., Mohan M., Moin I., Mok V., Molina G., Moloney J., Moneim J., Monfort Mira M., Montcusi Ventura B., Montouri M., Moossdorff M., Mora-Guzman I., Moran B., Moran R. A. R., Moreno-Ordaz S., Morera A., Morgan R., Morley R., Moro-Valdezate D., Moros S., Moss J. -L., Morven A., Morton D., Moynihan A., Moyon M., Muduli N., Mugla N., Mugla W., Muller P., Mun G., Mundhada R., Munir I., Munoz F., Munoz E., Munoz A., Munoz Balderas D. C., Murgitroyd E., Murray V., Murthy S., Mushiwokufa W., Mustafa H., Mustakimov B., Mutambanengwe P., Myint P., Nadkarni S., Naess P. A., Nahar S., Naidoo P., Nam R., Nandhra S., Nanjappa N., Narasimhan V., Nardi W., Nasir M., Naughton A., Naumann D., Navarro S., Nawaaz Karimbocus M., Nazir A., Ndereya S., Ndong A., Negoi I., Nel D., Nelson D., Nepal S., Nugent T., Nepogodiev D., Neufeld J., Ng J., Ng D., Ng C. E., Ngaserin S., Ngu L., Ngwenya E., Fhearaigh R. N., Nikolousakis T. -K., Ninkovic M., Nita G., Nitschke C., Noren E., Noton T., Novikova A., Nowinka Z., Nyakunengwa T., Nyalundja A., Nzenwa I., Kristensen H. O., O'Brien C., O'Brien L., O'Brien S., O'Reilly J., O'Rourke S., O'Sullivan M., O'Dwyer M., Ochieng L., Oderoha E., Oh K. E., Ohlberger L., Olcum M., Olkina A., Omkumar M., Omnitel B., Oncel Yakar D., Ong K., Ong Wei Lin L., Ooi R., Ooi S., Oomman A., Oon Tyjet D., Opiyo S., Oscullo Yepez J. J., Osei-Kuffour N., Osunronbi T., Ottlakan A., Oussama Kacimi S., Ovaere S., Ozair A., Pachler F., Pai Oo S., Paiella S., Panaiotti L., Panda N., Pandarinath S., Pandey D., Pandrowala S., Papa Mamadou F., Paranathala M., Park J., Parmar C., Parvez A., Pasovic L., Pasquer A., Pasumarthy N., Pata F., Patel T., Patel P., Patel N., Patel M., Patron Uriburu N., Patrone R., Paul A., Pavan Kumar O. M., Pavithran A., Pedraza Ciro M., Pellino G., Peloso A., Pena Gallardo M. T., Pena Velazquez A., Perea J., Perez-Sanchez L. E., Perra T., Perrotta G., Petersson P., Petra G., Petrucciani N., Pickin C., Pino V., Pinotti E., Pinto F., Plum P., Podesta F., Pollini T., Pompeu Sa M., Ponce Leon F., Ponniah H. S., Ponte De Sousa X., Ponton J., Pontula A., Popa M., Portilla A. L., Posner F., Post S., Potolicchio A., Pouwels S., Povo A., Prasad P., Preciado S., Preece R., Proud D., Pulido Segura J. A., Puliyath N., Qui M., Quimbaya Rodriguez A. S., Raby-Smith W., Racovita A., Rad A., Radwan R., Rafaih Iqbal M., Rafik A., Raguan B., Rahi M., Rahiri J. -L., Rahme J., Rai L., Raj A., Raj Saksena A., Raja M., Ramirez J., Ramzi J., Ranstam J., Rao C., Rashid A., Ratnayake B., Rattanasirivilai K., Raubenheimer K., Ravikumar N., Ravn S., Razoz N., Rea W., Regan A., Rela M., Remme A., Rey Chaves C. E., Reyes A., Riad A., Rice D., Rios Quintana K., Ritter A., Roalso M., Robinson D., Rodriguez J., Rodriguez F., Rodriguez M. C., Rogers A., Rohila J., Romanyuc D., Romic I., Rommaneh M., Rompianesi G., Rosa F., Roscio F., Rose A., Rotimi T., Ruiz H., Ruiz Yucuma J., Ruiz-Ucar E., Ruslan M., Rutegard M., Ryan Harper E., Ryckx A., Rydbeck D., Sa-Marta E., Sadien I., Safari Nteranya D., Sagoo K., Sakata S., Saladino E., Saleem A., Saleem S., Salehi M., Salih S., Sallinen V., Salvans S., Sam Z. 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F., Khan S., Khan M., Khan D., Khan H., Khatkar H., Khatkov E., Khaw R., Kim B., Kishore Siddiraju K., Kitua D., Kirimtay B., Kmezic S., Knight S., Koeter T., Koh A., Koh Hong Xiang F., Kojo Anyomih T., Kok A. I. N., Kokelaar R., Koliarakis I., Kolli S., Kong J., Konig D., Koshy M., Kotze P., Kourdouli A., Kowal M., Kraima A., Kramer F., Kryzauskas M., Kuchynskyi I., Kuemmerli C., Kuiper S., Kumar S., Kumar A., Kumar L., Kumar H., Kumar N., Kumar Bandyopadhyay S., Kumar Garg P., Kumar Venkatappa S., Kung J., Kural S., Kushairi A., Kuuzie E., Kvietkauskas M., Kwek I., La J., Lai L., Lakpriya S., Lam K., Lami M., Lansdorp-Vogelaar I., Lapolla P., Larsen H., Latif J., Laudari U., Laurnezi A., Lawal A., Lawday S., Lederhuber H., Lednev A., Lee R., Van Leerdam M. E., Lefevbre G., Lesmus M., Leyva Moraga F. A., Leyva Moraga E., Leyva Moraga F., Li H. L., Li A., Li Z., Licardie E., Light A., Lightner A. L., Lin A., Lincango E., Litta F., Liu H., Lofthouse B., Londono M. 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A., Nahar S., Naidoo P., Nam R., Nandhra S., Nanjappa N., Narasimhan V., Nardi W., Nasir M., Naughton A., Naumann D., Navarro S., Nawaaz Karimbocus M., Nazir A., Ndereya S., Ndong A., Negoi I., Nel D., Nelson D., Nepal S., Nugent T., Nepogodiev D., Neufeld J., Ng J., Ng D., Ng C. E., Ngaserin S., Ngu L., Ngwenya E., Fhearaigh R. N., Nikolousakis T. -K., Ninkovic M., Nita G., Nitschke C., Noren E., Noton T., Novikova A., Nowinka Z., Nyakunengwa T., Nyalundja A., Nzenwa I., Kristensen H. O., O'Brien C., O'Brien L., O'Brien S., O'Reilly J., O'Rourke S., O'Sullivan M., O'Dwyer M., Ochieng L., Oderoha E., Oh K. E., Ohlberger L., Olcum M., Olkina A., Omkumar M., Omnitel B., Oncel Yakar D., Ong K., Ong Wei Lin L., Ooi R., Ooi S., Oomman A., Oon Tyjet D., Opiyo S., Oscullo Yepez J. J., Osei-Kuffour N., Osunronbi T., Ottlakan A., Oussama Kacimi S., Ovaere S., Ozair A., Pachler F., Pai Oo S., Paiella S., Panaiotti L., Panda N., Pandarinath S., Pandey D., Pandrowala S., Papa Mamadou F., Paranathala M., Park J., Parmar C., Parvez A., Pasovic L., Pasquer A., Pasumarthy N., Pata F., Patel T., Patel P., Patel N., Patel M., Patron Uriburu N., Patrone R., Paul A., Pavan Kumar O. M., Pavithran A., Pedraza Ciro M., Pellino G., Peloso A., Pena Gallardo M. T., Pena Velazquez A., Perea J., Perez-Sanchez L. E., Perra T., Perrotta G., Petersson P., Petra G., Petrucciani N., Pickin C., Pino V., Pinotti E., Pinto F., Plum P., Podesta F., Pollini T., Pompeu Sa M., Ponce Leon F., Ponniah H. S., Ponte De Sousa X., Ponton J., Pontula A., Popa M., Portilla A. L., Posner F., Post S., Potolicchio A., Pouwels S., Povo A., Prasad P., Preciado S., Preece R., Proud D., Pulido Segura J. A., Puliyath N., Qui M., Quimbaya Rodriguez A. S., Raby-Smith W., Racovita A., Rad A., Radwan R., Rafaih Iqbal M., Rafik A., Raguan B., Rahi M., Rahiri J. -L., Rahme J., Rai L., Raj A., Raj Saksena A., Raja M., Ramirez J., Ramzi J., Ranstam J., Rao C., Rashid A., Ratnayake B., Rattanasirivilai K., Raubenheimer K., Ravikumar N., Ravn S., Razoz N., Rea W., Regan A., Rela M., Remme A., Rey Chaves C. E., Reyes A., Riad A., Rice D., Rios Quintana K., Ritter A., Roalso M., Robinson D., Rodriguez J., Rodriguez F., Rodriguez M. C., Rogers A., Rohila J., Romanyuc D., Romic I., Rommaneh M., Rompianesi G., Rosa F., Roscio F., Rose A., Rotimi T., Ruiz H., Ruiz Yucuma J., Ruiz-Ucar E., Ruslan M., Rutegard M., Ryan Harper E., Ryckx A., Rydbeck D., Sa-Marta E., Sadien I., Safari Nteranya D., Sagoo K., Sakata S., Saladino E., Saleem A., Saleem S., Salehi M., Salih S., Sallinen V., Salvans S., Sam Z. H., Samadov E., Sampaio Alves M., Sanad A., Sanchez Fonseca S., Sanchez Teran A., Sanchez Ussa S., Sandli O., Sanfey H., Sanghera J., Sani I., Santafe Guerrero M., Sante Fornasiero M., Santes Jasso O., Santos Pereira I., Santos Sousa H., Saratzis A., Sarmiento Alarcon A., Saumtally T., Sayyed R., Schettino M., Schleimer L., Schmidt T., Schondffelt K., Schwab M., Scott A., Searle H., Sebopelo L., Seeglier B., Seishima R., Semenvov D., Senent-Boza A., Sepulveda J., Serenari M., Serrano Navidad M., Sert I., Sewart E., Sgro A., Shadrina V., Shah K., Shahid F., Shalaby M., Shankar B., Shapiro J., Sharma L., Sheel A., Shenfine A., Shenoy S., Sherif A., Shetty N., Shetty R., Sia T. C., Sichimba D., Siddique H., Siddiqui I., Simkens G., Simoe J., Simon H., Sinan L., Singh T., Singh K., Singh Y., Sinha L., Siragusa L., Sluckin T., Smart Y. W., Smith H., Smith K., Smits L., Sneep-Van Kessel C., Sohrabi C., Solorzano Pineda O., Soma A., Sooriyapiragasam L., Soreide K., Sparavigna M., Spence R., Spencer N., Spiers H., Spinelli A., Sprakel J., Sravanam S., Srinivasan M., Srinivasan R., Staniszewska A., Stanworth S. J., Stasinos K., Steele R. J. C., Steinholt I., Steinruecke M., Stephen B. -J., Stijns J., Still M., Stupalkowska W., Subba S., Subbotin V. V., Sucharitkul P., Sudarsanam A., Sudhamsh Reddy D., Suhardja T., Suliman M., Sund M., Sunilkumar A., Suresh N., Sussmes S., Sutton P., Syltern J., Taha A., Takamizawa Y., Takoutsing Dongmo A. B., Tamas T., Tan L., Tan J. L., Tan K., Tan E., Tan Yong Hui A., Tanase A., Tariverdiev A., Tasnem A., Tatar C., Tay E., Tejedor P., Tesfaye G., Tetinou F., Thorpe C., Thyo A., Tlelo Amastal D., Tolani M., Tolga Saracoglu K., Tolgyes T., Tong J., Torrent Jansa L., Toscano Igartua S., Tovani Palone M. R., Traff H., Trevis J., Tummers W., Tur A., Turchenko I., Uche V., Uddin A., Udonsak N., Ullah M., Urbonas T., Uwins C., Uy Magadia E., Uzair Qureshi A., Uzun K., Vadim P., Valarche G., Valdez Gonzalez R. A., Vallee M., Van Beek D. -J., Van Dalen A. S., Van Den Hondel D., Van Der Stok E., Van Dorp M., Van Oostendorp S., Van Praag E., Van Rees J., Van Silfhout L., Varga Z., Varghese S., Varghese C., Varghese J., Vasilica A. -M., Vasquez Ojeda X., Vega E., Vehler S., Venchiarutti R., Vengatesan S., Venn M., Verma D., Vianey Partida Nava G., Victoria D., Vieira P., Vilar Alvarez M. E., Vinci D., Viscasillas Pallas G., Viswanath M., Vivanco J., Vizcaya Rodriguez V., Vo J., Volchanski D., Voron T., Voronovskyi Y., Vu J., Wadhwa M., Wadhwa S., Wagner G., Wallace M., Wang Y. Y., Wang J., Wani A., Wanigasooriya K., Wanjara S., Wanjiku N., Warner C., Wei Leow T., Weiser T., Weisters M., Wellington M. J., Wells C., Wenzelberg C., Wettstein D., Wezel A., Wheldon L., Widmer L., Wilson M., Wigmore S., Wijayaratne T., Wijeyaratne M., Wijnhoven B. P. L., Wilkin R., Williams E., Willis F., Winter D., Wirsik M. M., Wishah B., Wong G., Wong W. J., Wong K., Wong K. -Y., Worku D., Wright E., Wright J., Wroe Wright O., Xenacki S., Xia W., Xu W., Xu Z., Yalcinkaya A., Yang W., Yang P. -C., Yanishev A., Yanzon De La Torre A., Yao H., Yaqoob E., Yen Ling Quake S., Yeo D., Yeom B., Yershov D., Yiasemidou M., Yildiz A., Yiu A., Yoav M., Yong E., Yoshimura R., Younis M. U., Younis Ringshawl Z., Youssef M., Yue Y., Yuen S., Yuldashev R., Yurttas C., Yves B., Zaborowski A., Zackeri R., Zafar A., Zahra W., Zaidi A., Zainudin S., Zakeri R., Zamora I., Zamora A. T., Zawistowski M., Zbikowska G., Zegers W., Zehra S., Zeyra A., Zhagniyev Z., Zhukova L. G., Zivanovic M., Zmuc J., Zope M., Zubayraeva A., and Zucker B.
- Abstract
Background: Coronavirus disease 2019 (COVID-19) was declared a pandemic by the WHO on 11 March 2020 and global surgical practice was compromised. This Commission aimed to document and reflect on the changes seen in the surgical environment during the pandemic, by reviewing colleagues experiences and published evidence. Methods: In late 2020, BJS contacted colleagues across the global surgical community and asked them to describe how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had affected their practice. In addition to this, the Commission undertook a literature review on the impact of COVID-19 on surgery and perioperative care. A thematic analysis was performed to identify the issues most frequently encountered by the correspondents, as well as the solutions and ideas suggested to address them. Results: BJS received communications for this Commission from leading clinicians and academics across a variety of surgical specialties in every inhabited continent. The responses from all over the world provided insights into multiple facets of surgical practice from a governmental level to individual clinical practice and training. Conclusion: The COVID-19 pandemic has uncovered a variety of problems in healthcare systems, including negative impacts on surgical practice. Global surgical multidisciplinary teams are working collaboratively to address research questions about the future of surgery in the post-COVID-19 era. The COVID-19 pandemic is severely damaging surgical training. The establishment of a multidisciplinary ethics committee should be encouraged at all surgical oncology centres. Innovative leadership and collaboration is vital in the post-COVID-19 era.
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- 2021
6. Trends in surgical techniques for the treatment of esophageal and gastroesophageal junction cancer: the 2022 update.
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Groot, E M de, Goense, L, Kingma, B F, Haverkamp, L, Ruurda, J P, and Hillegersberg, R van
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ESOPHAGOGASTRIC junction ,OPERATIVE surgery ,GASTROINTESTINAL surgery ,ESOPHAGUS diseases ,ESOPHAGECTOMY - Abstract
The aim of this study was to evaluate the current practice in surgical techniques for esophageal and gastroesophageal junction cancer surgery worldwide and to compare the results to the previous surveys in 2007 and 2014. An online survey was sent out among surgical members of the International Society for Diseases of the Esophagus, the World Organization for Specialized Studies on Disease of the Esophagus, the International Gastric Cancer Association, the Association of Upper Gastrointestinal Surgery of Great Britain and Ireland and Dutch gastroesophageal surgeons via the network of the investigators. In total, 260 surgeons completed the survey representing 52 countries and 6 continents; Europe 56%, Oceania 14%, Asia 14%, South-America 9%, North-America 7%. Of the responding surgeons, 39% worked in a hospital that performed >51 esophagectomies per year. Total minimally invasive esophagectomy was the preferred technique (53%) followed by hybrid esophagectomy (26%) of which 7% consisted of a minimally invasive thoracic phase and 19% of a minimally invasive abdominal phase. Total open esophagectomy was preferred by 21% of the respondents. Total minimally invasive esophagectomy was significantly more often performed in high-volume centers compared with non-high-volume centers (P = 0.002). Robotic assistance was used in 13% during the thoracic phase and 6% during the abdominal phase. Minimally invasive transthoracic esophagectomy has become the preferred approach for esophagectomy. Although 21% of the surgeons prefer an open approach, 26% of the surgeons perform a hybrid procedure which may reflect further transition towards the use of total minimally invasive esophagectomy. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Oncologic Long-Term Results of Robot-Assisted Minimally Invasive Thoraco-Laparoscopic Esophagectomy with Two-Field Lymphadenectomy for Esophageal Cancer
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van der Sluis, P. C., Ruurda, J. P., Verhage, R. J. J., van der Horst, S., Haverkamp, L., Siersema, P. D., Borel Rinkes, I. H. M., ten Kate, F. J. W., and van Hillegersberg, R.
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- 2015
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8. Prophylactic Laparoscopic Total Gastrectomy with Jejunal Pouch Reconstruction in Patients Carrying a CDH1 Germline Mutation
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Haverkamp, L., van der Sluis, P.C., Ausems, M.G.E.M., van der Horst, S., Siersema, P.D., Ruurda, J.P., Offerhaus, G.J.A., and van Hillegersberg, R.
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- 2015
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9. Surgical Treatment of Adenocarcinomas of the Gastro-esophageal Junction
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Parry, K., Haverkamp, L., Bruijnen, R. C. G., Siersema, P. D., Ruurda, J. P., and van Hillegersberg, R.
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- 2015
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10. Worldwide Practice in Gastric Cancer Surgery: A 6-Year Update
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Gertsen, EC, Brenkman, HJF, Haverkamp, L, Read, M, Ruurda, JP, van Hillegersberg, R, Gertsen, EC, Brenkman, HJF, Haverkamp, L, Read, M, Ruurda, JP, and van Hillegersberg, R
- Abstract
OBJECTIVES: The aim of the study was to evaluate the current status of gastric cancer surgery worldwide and update the changes compared to a previous survey in 2014. METHODS: A cross-sectional survey was sent to surgical members of the International Gastric Cancer Association, pilot centers of the World Organization for Specialized Studies on Diseases of the Esophagus, and the Australian and New Zealand Gastric and Oesophageal Surgeons Association in addition to participants of the 2019 International Gastric Cancer and European Society for Diseases of the Esophagus congresses. Topics addressed included hospital volume, staging, perioperative treatment, surgical approach, anastomotic techniques, lymphadenectomy, and palliative management. RESULTS: Between June 2019 and January 2020, 165 respondents from 44 countries completed the survey. In total, 80% worked in a hospital performing >20 gastrectomies annually. Staging laparoscopy and 18F-fluorodeoxyglucose positron emission tomography with computed tomography were preferred by 68 and 26% for advanced cancer, and 90% offered perioperative chemo(radio)therapy to patients. For early cancer, a minimally invasive surgical approach was preferred by 65% for distal and by 50% for total gastrectomy. For advanced cancer, this was preferred by 39% for distal and by 33% for total gastrectomy. And 84% favored a stapled anastomosis, and 14% created a jejunal pouch as reconstruction during total gastrectomy. A D2 lymphadenectomy was preferred for distal as well as for total gastrectomy, in both early (62 and 71%) and advanced (84 and 89%) cancer. CONCLUSION: This international survey demonstrates that perioperative chemotherapy and a D2 lymphadenectomy have now become the preferred treatment for gastric cancer. A minimally invasive surgical approach has gained popularity.
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- 2021
11. Worldwide trends in surgical techniques in the treatment of esophageal and gastroesophageal junction cancer
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Haverkamp, L., Seesing, M. F J, Ruurda, J. P., Boone, J., and van Hillegersberg, R.
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Esophagus ,Gastroesophageal junction ,Gastroenterology ,Journal Article ,Surgery ,Cancer - Abstract
The aim of this study was to evaluate the worldwide trends in surgical techniques for esophageal cancer surgery by comparing it to our survey from 2007. In addition, new questions were added for gastroesophageal junction (GEJ) cancer. An international survey on surgery of esophageal and GEJ cancer was performed among surgical members of the International Society for Diseases of the Esophagus, the World Organization for Specialized Studies on Disease of the Esophagus, the International Gastric Cancer Association. Also, surgeons from personal networks were contacted. The participants filled out a web based questionnaire about surgical strategies for esophageal and gastroesophageal cancer. The overall response rate was 478/1147 (42%). The respondents represented 49 different countries and 6 different continents. The annual cumulative number of esophageal and gastric resections per surgeon was low (≤11) in 11%, medium (11-21) in 17%, and high (≥21) in 72% of respondents. In a subgroup analysis of esophageal surgeons the number of high volume surgeons increased from 45 to 54% over the past 7 years. The preferred lymph node dissection was two-field in 86%. A gastric conduit was the preferred method of reconstruction in 95%. In 2014, the preferred approach to esophagectomy was minimally invasive transthoracic in 43%, compared with 14% in 2007. In minimally invasive transthoracic esophagectomy the cervical anastomosis was favored in 54% of respondents in 2014 compared with 87% in 2007. The preferred technique of construction of the cervical anastomosis was hand-sewn in 64% and stapled in 36%, whereas the thoracic anastomosis was stapled in 77% and hand-sewn in 23%. The preferred surgical approach for Siewert type 1 tumors (5-1 cm proximal of the GEJ) was esophagectomy in 93% of respondents, whereas 6% favored gastrectomy and 3% combined a distal esophagectomy with a proximal gastrectomy. For Siewert type 2 tumors (1-2 cm from the GEJ) an extended gastrectomy was favored by 66% of respondents, followed by esophagectomy in 27% and total gastrectomy in 7%. Siewert type 3 tumors (2-5 cm distal of the GEJ) were preferably treated with gastrectomy in 90% of respondents, esophagectomy in 6%, and extended gastrectomy in 4%. The preferred curative surgical treatment of esophageal cancer is minimally invasive transthoracic esophagectomy with a two-field lymph node dissection and gastric conduit reconstruction. A strong worldwide trend toward minimally invasive surgery is observed. The preferred surgical treatment of GEJ tumors is esophagectomy for Siewert type 1 tumors and gastrectomy for Siewert type 3 tumors. The majority of surgeons favor an extended gastrectomy for Siewert type 2 tumors.
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- 2017
12. Worldwide trends in surgical techniques in the treatment of esophageal and gastroesophageal junction cancer
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MS CGO, Cancer, Divisie Beeld & Oncologie, Haverkamp, L., Seesing, M. F J, Ruurda, J. P., Boone, J., van Hillegersberg, R., MS CGO, Cancer, Divisie Beeld & Oncologie, Haverkamp, L., Seesing, M. F J, Ruurda, J. P., Boone, J., and van Hillegersberg, R.
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- 2017
13. Early Development of Behavior and the Nervous System : An Embryological Perspective
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Oppenheim, R. W., Haverkamp, L., Adler, Norman T., editor, and Blass, Elliott M., editor
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- 1986
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14. Esophageal and Gastric Cancer Pearl: a nationwide clinical biobanking project in the Netherlands
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Haverkamp, L., Parry, K., Henegouwen, M.I.V., Laarhoven, H.W. van, Bonenkamp, J.J., Bisseling, T.M., Siersema, P.D., Sosef, M.N., Stoot, J.H., Beets, G.L., Steur, W.O. de, Hartgrink, H.H., Verspaget, H.W., Peet, D.L. van der, Plukker, J.T., Etten, B. van, Wijnhoven, B.P.L., Lanschot, J.J. van, Hillegersberg, R. van, Ruurda, J.P., RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Surgery, Oncology, CCA - Biomarkers, Damage and Repair in Cancer Development and Cancer Treatment (DARE), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)
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the Netherlands ,LONG-TERM SURVIVAL ,ADENOCARCINOMA ,esophageal and gastric cancer ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,biobanking ,SDG 3 - Good Health and Well-being ,UK BIOBANK ,JUNCTION ,Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14] ,CARDIA ,PATTERNS ,Journal Article ,biobanking, esophageal and gastric cancer, the Netherlands - Abstract
Item does not contain fulltext Esophageal and gastric cancer is associated with a poor prognosis since many patients develop recurrent disease. Treatment requires specific expertise and a structured multidisciplinary approach. In the Netherlands, this type of expertise is mainly found at the University Medical Centers (UMCs) and a few specialized nonacademic centers. Aim of this study is to implement a national infrastructure for research to gain more insight in the etiology and prognosis of esophageal and gastric cancer and to evaluate and improve the response on (neoadjuvant) treatment. Clinical data are collected in a prospective database, which is linked to the patients' biomaterial. The collection and storage of biomaterial is performed according to standard operating procedures in all participating UMCs as established within the Parelsnoer Institute. The collected biomaterial consists of tumor biopsies, blood samples, samples of malignant and healthy tissue of the resected specimen and biopsies of recurrence. The collected material is stored in the local biobanks and is encoded to respect the privacy of the donors. After approval of the study was obtained from the Institutional Review Board, the first patient was included in October 2014. The target aim is to include 300 patients annually. In conclusion, the eight UMCs of the Netherlands collaborated to establish a nationwide database of clinical information and biomaterial of patients with esophageal and gastric cancer. Due to the national coverage, a high number of patients are expected to be included. This will provide opportunity for future studies to gain more insight in the etiology, treatment and prognosis of esophageal and gastric cancer.
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- 2016
15. Advances in Gastric and Gastro-Esophageal Junction Surgery for Cancer
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Haverkamp, L., Hillegersberg, R. van, Ruurda, J.P., and University Utrecht
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Esophagectomy ,CDH1 ,Gastrectomy ,Gastric ,Surgery ,Laparoscopy ,Cardia ,Gastro-Esophageal Junction ,Omentum ,Cancer - Abstract
Chapter 1 – Introduction Gastric cancer is conventionally treated by means of open distal or total gastrectomy. The open surgical approach is associated with high morbity and long postoperative hospital stay. Minimally invasive surgery is upcoming for gastric cancer, since promosing results in the treatment of other abdominal diseases were booked. This thesis consists of 2 parts. In the first part the value of laparoscopic gastrectomy is described. In the second part the surgical treatment of tumors located at the gastro-esophageal junction is evaluated. These tumors are located at the transistional area between the esophagus and stomach and are therefore difficult to treat. PART 1 – GASTRIC CANCER SURGERY Chapter 2 In this systematic meta-analysis of comparative cohort studies the short-term outcomes of laparoscopic total gastrectomy versus open total gastrectomy in the treatment of gastric cancer were evaluated. Laparoscopic total gastrectomy was associated with reduced blood loss, lower short-term complication rates, and quicker functional recovery, at the price of a longer operating time. The included studies did not elaborate on oncologic outcome, long-term survival, or quality of life. Chapter 3 This international cross-sectional survey revealed the current preferences in gastric cancer surgery. Members of the International Gastric Cancer Association filled in a web-based questionnaire about surgical techniques and approaches. The majority (79%) of respondents performed >21 gastrectomies per year. Open gastrectomy was preferred over laparoscopic gastrectomy (distal: 35% for early and 91% for advanced cancer; total: 52% for early and 94% for advanced cancer). Resection of the greater omentum was favored by the majority (89%) of respondents. A Roux-en-Y reconstruction with a jejunal pouch was preferably performed after total gastrectomy by a minority of respondents (17%). Thus far, as a reflection of the current practice, the minimally invasive techniques have not been generally implemented in clinical guidelines. Chapter 4 In the UMC Utrecht cohort of patients with an identified germline ecadherin-1 (CDH1) mutation, prophylactic laparoscopic total gastrectomy was performed to eliminate the high risk of developing diffuse gastric cancer. The median operative time was 4:19 (3:15-6:03) hours and the median blood loss was 200 (20-400) ml. Median length of hospital stay was 10 (7-27) days. The 60-day mortality rate was 0%. Multiple foci of intramucosal diffuse gastric signet ring cell carcinoma were found in the resection specimen of 9/11 (82%) patients. All resections were microscopically radical. Enhanced postoperative recovery and reduced surgical trauma may especially be relevant to patients with a germline CDH1 mutation, since they have a higher life expectancy than patients with actual gastric cancer. Chapter 5 Laparoscopic gastrectomy was performed in our cohort of Western European patients with predominantly locally advanced gastric cancer. The median intraoperative blood loss was 305 (30-2700) milliliters. The median postoperative hospital stay was 11 (5-91) days. The 30-day mortality was 4.3%. A radical resection was achieved in the vast majority of patients (90%). The median number of dissected lymph nodes was 17 (2-62). We demonstrated that laparoscopic gastrectomy can safely be performed in Western European patients with advanced gastric cancer and meets the oncologic standard. Chapter 6 Omentectomy additional to gastrectomy is considered to be the standard surgical technique in the curative treatment of patients with resectable gastric cancer. In our prospective series of patients undergoing gastrectomy the greater omentum was marked during operation and pathologically analyzed to evaluate the presence of omental lymph nodes, tumor deposits and patterns of lymphatic spread. The omental lymph nodes contained metastases in 1 (2%) patient with stage IB gastric cancer. Omental tumor deposits were found in 4 (8%) patients stage IB-IIIA, of which 3 underwent perioperative chemotherapy. No significant differences in 1-year overall survival (p=0.106) and 1-year disease-free survival (p=0.258) for patients with and without omental lymph node metastases or tumor deposits were found. No predictive factors for omental tumor involvement could be identified. Therefore, omentectomy should be the standard in gastrectomy for all gastric cancer patients. Chapter 7 In order to evaluate the laparoscopic gastrectomy compared to open gastrectomy in a large national setting a non-blinded, multicenter, prospectively randomized controlled superiority trial was designed. Patients (n=210) with resectable gastric cancer will be enrolled. The primary outcome is postoperative hospital stay (days). Secondary outcome parameters include postoperative morbidity and mortality, oncologic outcomes, readmissions, quality of life and cost-effectiveness. It is hypothesized that the functional recovery is faster in the laparoscopic group. Also, it is expected that laparoscopic gastrectomy will be associated with a lower postoperative morbidity, less readmissions, higher cost-effectiveness, better postoperative quality of life, with similar mortality and oncologic outcomes, compared to open gastrectomy. Chapter 8 A major complication of gastrectomy is leakage of the esophagojejunostomy. Sealing the anastomosis with a fibrin patch (TachoSil) containing a human fibrinogen and thrombin, may improve mechanical strength of the anastomosis. A feasibility study of 15 patients with an esophageal anastomosis was performed. The sealant patch could be applied successfully in all patients. A median of 2 (1-6) attempts were necessary to reach successful application. The median duration was 7 (3-26) minutes before successful application was accomplished. In patients that underwent total gastrectomy, the patch was folded into a harmonica shape and wrapped around the esophagojejunostomy. PART 2 – GASTRO-ESOPHAGEAL JUNCTION CANCER SURGERY Chapter 9 Adenocarcinomas of the Gastro-Esophageal Junction (GEJ) are located at the transition zone between the esophagus and the stomach. The optimal surgical treatment of patients with this type of cancer has not been established yet. In a systematic review cohort studies comparing gastrectomy versus esophagectomy were evaluated. Radical resection rates varied between 72–93% for esophagectomy and 62%–93% for gastrectomy. Morbidity was 33–39% after esophagectomy versus 11–54% after gastrectomy. The 30-day mortality ranged between 1.0–2.3 after esophagectomy and 1.8–2.7% after gastrectomy. At 6 months after surgery, health-related quality of life was higher after total gastrectomy than after esophagectomy. The 5-year survival rates varied between 30–42% for esophagectomy and 18–38% for gastrectomy, but were not significantly different. In the selection of the most optimal surgical strategy, it is important to choose a surgical procedure that allows for radical resection of the GEJ tumor with dissection of adjacent lymph nodes. If both surgical strategies are deemed possible, a gastrectomy appears to offer the best long-term quality of life perspective. Chapter 10 To evaluate the international preferences in the surgical treatment of GEJ tumors a survey was performed amongst surgical members of the International Society for Diseases of the Esophagus, the World Organization for Specialized Studies on Disease of the Esophagus and the International Gastric Cancer Association. The preferred surgical approach for Siewert type 1 tumors (5-1 cm proximal of the GEJ) was esophagectomy in 93% of respondents, whereas 6% favored gastrectomy and 3% combined a distal esophagectomy with a proximal gastrectomy. For Siewert type 2 tumors (1-2 cm from the GEJ) an extended gastrectomy was favored by 66% of respondents, followed by esophagectomy in 27% and total gastrectomy in 7%. Siewert type 3 tumors (2-5 cm distal of the GEJ) were preferably treated with gastrectomy in 90% of respondents, esophagectomy in 6% and extended gastrectomy in 4%. For choosing optimal treatment for GEJ tumors, adequate determination of tumor location is pivotal because the location affects the surgical procedure. Esophagogastroscopy was deemed most important by 81% of respondents, followed by CTscan in 14%, EUS in 2%, PETscan in 1%, and diagnostic laparoscopy in 1%. Also, the classification that is used affects surgical treatment. A combination of the Siewert classification and the TNM7 classification was preferred by 45% of respondents, whereas 39% used the Siewert classification only and 16% solely favored the TNM7 classification. Chapter 11 In the prospective UMC Utrecht database of 266 consecutive patients with surgically resectable GEJ adenocarcinomas the diagnostic staging was analyzed. The accuracy of EUS and CT regarding tumor localization according to Siewert, nodal status and its consequences on treatment strategy were assessed. Overall accuracy in determining tumor localization was 73% for EUS and 61% for CT (p=0.018). For EUS, the accuracy decreased when patients were treated with neoadjuvant therapy (82% to 70%, p=0.023), with CT no difference was found (62% to 61%, p=0.884). Accuracy for determining a positive nodal station in patients without neoadjuvant therapy was 77% for EUS and 71% for CT (p=0.001). Accuracy for detecting upper mediastinal lymph nodes was 80–92%, compared to 50–80% for peritumoral and abdominal nodes in both EUS and CT. A radical resection was performed in 88% of patients. Despite the suboptimal accuracy of determining tumor localization with EUS and CT, in only a small number of patients (3%) an intraoperative change of surgical treatment was needed. EUS is superior to CT in determining nodal status and tumor localization in GEJ tumors. Chapter 12 In the prospective UMC Utrecht database of 266 consecutive patients with surgically resectable GEJ adenocarcinomas the surgical treatment was analyzed. Post-operative histopathological analysis revealed that 25% of patients had a type I tumor, 66% a type II tumor, 6% a type III tumor. I n total, 86% were treated with esophagectomy and 14% with gastrectomy. In patients with a type II GEJ adenocarcinoma, a positive circumferential resection margin was more common with gastrectomy than esophagectomy (29 vs. 11 %; p = 0.025). However, the type of operation did not significantly influence overall survival on multivariate analysis (p = 0.606). Upper mediastinal nodal involvement was present in 11% of patients with a type II tumor.
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- 2015
16. Esophageal and Gastric Cancer Pearl: a nationwide clinical biobanking project in the Netherlands
- Author
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Haverkamp L, Parry K, Mi, Berge Henegouwen, Hw, Laarhoven, Jj, Bonenkamp, Tm, Bisseling, Pd, Siersema, Mn, Sosef, Jan Stoot, Gl, Beets, Wo, Steur, Hh, Hartgrink, Hw, Verspaget, Dl, Peet, Jt, Plukker, van Etten B, Bp, Wijnhoven, Jj, Lanschot, van Hillegersberg R, and Jp, Ruurda
- Subjects
Male ,Academic Medical Centers ,Databases, Factual ,Esophageal Neoplasms ,Stomach Neoplasms ,Blood Banks ,Humans ,Female ,Prospective Studies ,Tissue Banks ,Neoplasm Recurrence, Local ,Netherlands - Abstract
Esophageal and gastric cancer is associated with a poor prognosis since many patients develop recurrent disease. Treatment requires specific expertise and a structured multidisciplinary approach. In the Netherlands, this type of expertise is mainly found at the University Medical Centers (UMCs) and a few specialized nonacademic centers. Aim of this study is to implement a national infrastructure for research to gain more insight in the etiology and prognosis of esophageal and gastric cancer and to evaluate and improve the response on (neoadjuvant) treatment. Clinical data are collected in a prospective database, which is linked to the patients' biomaterial. The collection and storage of biomaterial is performed according to standard operating procedures in all participating UMCs as established within the Parelsnoer Institute. The collected biomaterial consists of tumor biopsies, blood samples, samples of malignant and healthy tissue of the resected specimen and biopsies of recurrence. The collected material is stored in the local biobanks and is encoded to respect the privacy of the donors. After approval of the study was obtained from the Institutional Review Board, the first patient was included in October 2014. The target aim is to include 300 patients annually. In conclusion, the eight UMCs of the Netherlands collaborated to establish a nationwide database of clinical information and biomaterial of patients with esophageal and gastric cancer. Due to the national coverage, a high number of patients are expected to be included. This will provide opportunity for future studies to gain more insight in the etiology, treatment and prognosis of esophageal and gastric cancer.
- Published
- 2015
17. Staging of adenocarcinoma of the gastroesophageal junction
- Author
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Parry, K., Haverkamp, L., Bruijnen, R.C., Siersema, P.D., Offerhaus, G.J., Ruurda, J.P., Hillegersberg, R. van, Parry, K., Haverkamp, L., Bruijnen, R.C., Siersema, P.D., Offerhaus, G.J., Ruurda, J.P., and Hillegersberg, R. van
- Abstract
Item does not contain fulltext, BACKGROUND: Clinical staging of adenocarcinoma of the gastroesophageal junction (GEJ) determines the curative treatment regimen containing either neoadjuvant chemotherapy or chemoradiotherapy followed by either gastrectomy or esophagectomy. The value of current diagnostic tools is a matter of debate. METHODS: A prospective database (2003-2013) was used to identify 266 consecutive patients with adenocarcinoma of the GEJ in order to evaluate the accuracy of endoscopic ultrasound (EUS) and computed tomography (CT) regarding tumor localization according to Siewert, nodal status and its consequences on treatment strategy. RESULTS: Overall accuracy in determining tumor localization was 73% for endoscopy/EUS and 61% for CT (p = 0.018). With endoscopy/EUS, the accuracy was 97%, 66% and 75% respectively for type I, II and III. With CT this was respectively 69%, 57% and 80%. The overall accuracy for determining N-status (N0/N+) per patient was 75% for EUS and 71% for CT. Accuracy for determining a positive nodal station in patients without neoadjuvant therapy was 77% for EUS and 71% for CT (p = 0.001). Accuracy for detecting positive upper mediastinal nodes was 80-92%, whereas for peritumoral and abdominal nodes this was 50-80% in both EUS and CT. In 8/266 patients (3%) the type of surgery changed due to intraoperative findings. A radical resection was performed in 233 patients (88%). CONCLUSIONS: Despite the suboptimal accuracy of determining tumor localization with EUS and CT, in only a small number of patients an intraoperative change of surgical treatment was needed. EUS is superior to CT in determining nodal status and tumor localization in GEJ tumors.
- Published
- 2016
18. Laparoscopic gastrectomy in Western European patients with advanced gastric cancer
- Author
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Haverkamp, L., Ruurda, J. P., Offerhaus, G. J A, Weijs, T. J., van der Sluis, P. C., van Hillegersberg, R., Haverkamp, L., Ruurda, J. P., Offerhaus, G. J A, Weijs, T. J., van der Sluis, P. C., and van Hillegersberg, R.
- Published
- 2016
19. Staging of adenocarcinoma of the gastroesophageal junction
- Author
-
MS CGO, MS Radiologie, Infection & Immunity, Cancer, MS MDL 1, Other research (not in main researchprogram), Divisie Beeld & Oncologie, Parry, K., Haverkamp, L., Bruijnen, R. C G, Siersema, P. D., Offerhaus, G. J A, Ruurda, J. P., Van Hillegersberg, R., MS CGO, MS Radiologie, Infection & Immunity, Cancer, MS MDL 1, Other research (not in main researchprogram), Divisie Beeld & Oncologie, Parry, K., Haverkamp, L., Bruijnen, R. C G, Siersema, P. D., Offerhaus, G. J A, Ruurda, J. P., and Van Hillegersberg, R.
- Published
- 2016
20. Laparoscopic gastrectomy in Western European patients with advanced gastric cancer
- Author
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Cancer, Pathologie Pathologen staf, MS CGO, Other research (not in main researchprogram), Heelkunde Opleiding, Haverkamp, L., Ruurda, J. P., Offerhaus, G. J A, Weijs, T. J., van der Sluis, P. C., van Hillegersberg, R., Cancer, Pathologie Pathologen staf, MS CGO, Other research (not in main researchprogram), Heelkunde Opleiding, Haverkamp, L., Ruurda, J. P., Offerhaus, G. J A, Weijs, T. J., van der Sluis, P. C., and van Hillegersberg, R.
- Published
- 2016
21. Surgical treatments for esophageal cancers
- Author
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Allum, WH, Bonavina, L, Cassivi, SD, Cuesta, MA, Dong, ZM, Felix, VN, Figueredo, E, Gatenby, PAC, Haverkamp, L, Ibraev, MA, Krasna, MJ, Lambert, R, Langer, R, Lewis, MPN, Nason, KS, Parry, K, Preston, SR, Ruurda, JP, Schaheen, LW, Tatum, RP, Turkin, IN, Van Der Horst, S, Van Der Peet, DL, Van Der Sluis, PC, Van Hillegersberg, R, Wormald, JCR, Wu, PC, Zonderhuis, BM, Surgery, and CCA - Innovative therapy
- Subjects
Article - Abstract
The following, from the 12th OESO World Conference: Cancers of the Esophagus, includes commentaries on the role of the nurse in preparation of esophageal resection (ER); the management of patients who develop high‐grade dysplasia after having undergone Nissen fundoplication; the trajectory of care for the patient with esophageal cancer; the influence of the site of tumor in the choice of treatment; the best location for esophagogastrostomy; management of chylous leak after esophagectomy; the optimal approach to manage thoracic esophageal leak after esophagectomy; the choice for operational approach in surgery of cardioesophageal crossing; the advantages of robot esophagectomy; the place of open esophagectomy; the advantages of esophagectomy compared to definitive chemoradiotherapy; the pathologist report in the resected specimen; the best way to manage patients with unsuspected positive microscopic margin after ER; enhanced recovery after surgery for ER: expedited care protocols; and long‐term quality of life in patients following esophagectomy.
- Published
- 2014
22. Staging of adenocarcinoma of the gastroesophageal junction
- Author
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Parry, K., primary, Haverkamp, L., additional, Bruijnen, R.C.G., additional, Siersema, P.D., additional, Offerhaus, G.J.A., additional, Ruurda, J.P., additional, and van Hillegersberg, R., additional
- Published
- 2016
- Full Text
- View/download PDF
23. Worldwide trends in surgical techniques in the treatment of esophageal and gastroesophageal junction cancer
- Author
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Haverkamp, L., primary, Seesing, M. F. J., additional, Ruurda, J. P., additional, Boone, J., additional, and Hillegersberg, R. v., additional
- Published
- 2016
- Full Text
- View/download PDF
24. Laparoscopic gastrectomy in Western European patients with advanced gastric cancer
- Author
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Haverkamp, L., primary, Ruurda, J.P., additional, Offerhaus, G.J.A., additional, Weijs, T.J., additional, van der Sluis, P.C., additional, and van Hillegersberg, R., additional
- Published
- 2016
- Full Text
- View/download PDF
25. Oncologic Long-Term Results of Robot-Assisted Minimally Invasive Thoraco-Laparoscopic Esophagectomy with Two-Field Lymphadenectomy for Esophageal Cancer
- Author
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Sluis, P.C. van der, Ruurda, J.P., Verhage, R.J., Horst, S. van der, Haverkamp, L., Siersema, P.D., Rinkes, I.H., Kate, F.J. ten, Hillegersberg, R. van, Sluis, P.C. van der, Ruurda, J.P., Verhage, R.J., Horst, S. van der, Haverkamp, L., Siersema, P.D., Rinkes, I.H., Kate, F.J. ten, and Hillegersberg, R. van
- Abstract
Contains fulltext : 152552.pdf (Publisher’s version ) (Open Access), BACKGROUND: Open transthoracic esophagectomy is the worldwide gold standard in the treatment of resectable esophageal cancer. Robot-assisted minimally invasive thoraco-laparoscopic esophagectomy (RAMIE) for esophageal cancer may be associated with reduced blood loss, shorter intensive care unit (ICU) stay, and less cardiopulmonary morbidity; however, long-term oncologic results have not been reported to date. METHODS: Between June 2007 and September 2011, a total of 108 patients with potentially resectable esophageal cancer underwent RAMIE at the University Medical Centre Utrecht, with curative intent. All data were recorded prospectively. RESULTS: Median duration of the surgical procedure was 381 min (range 264-636). Pulmonary complications were most common and were observed in 36 patients (33 %). Median ICU stay was 1 day, and median overall postoperative hospital stay was 16 days. In-hospital mortality was 5 %. The majority of patients (78 %) presented with T3 and T4 disease, and 68 % of patients had nodal-positive disease (cN1-3). In 65 % of patients, neoadjuvant treatment (chemotherapy 57 %, chemoradiotherapy 7 %, radiotherapy 1 %) was administered, and in 103 (95 %) patients, a radical resection (R0) was achieved. The median number of lymph nodes was 26, median follow-up was 58 months, 5-year overall survival was 42 %, median disease-free survival was 21 months, and median overall survival was 29 months. Tumor recurrence occurred in 51 patients and was locoregional only in 6 (6 %) patients, systemic only in 31 (30 %) patients, and combined in 14 (14 %) patients. CONCLUSION: RAMIE was shown to be oncologically effective, with a high percentage of R0 radical resections and adequate lymphadenectomy. RAMIE provided good local control with a low percentage of local recurrence at long-term follow up.
- Published
- 2015
26. Esophageal and Gastric Cancer Pearl : a nationwide clinical biobanking project in the Netherlands
- Author
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Haverkamp, L, Parry, K, van Berge Henegouwen, M I, van Laarhoven, H W, Bonenkamp, J J, Bisseling, T M, Siersema, P D, Sosef, M N, Stoot, J H, Beets, G L, de Steur, W O, Hartgrink, H H, Verspaget, H W, van der Peet, D L, Plukker, J T, van Etten, B, Wijnhoven, B P L, van Lanschot, J J, van Hillegersberg, R, Ruurda, J P, Haverkamp, L, Parry, K, van Berge Henegouwen, M I, van Laarhoven, H W, Bonenkamp, J J, Bisseling, T M, Siersema, P D, Sosef, M N, Stoot, J H, Beets, G L, de Steur, W O, Hartgrink, H H, Verspaget, H W, van der Peet, D L, Plukker, J T, van Etten, B, Wijnhoven, B P L, van Lanschot, J J, van Hillegersberg, R, and Ruurda, J P
- Published
- 2015
27. Surgical treatment of adenocarcinomas of the gastro-esophageal junction
- Author
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Parry, K, Haverkamp, L, Bruijnen, R C G, Siersema, P D, Ruurda, J P, van Hillegersberg, R, Parry, K, Haverkamp, L, Bruijnen, R C G, Siersema, P D, Ruurda, J P, and van Hillegersberg, R
- Published
- 2015
28. Advances in Gastric and Gastro-Esophageal Junction Surgery for Cancer
- Author
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Hillegersberg, R. van, Ruurda, J.P., Haverkamp, L., Hillegersberg, R. van, Ruurda, J.P., and Haverkamp, L.
- Published
- 2015
29. Laparoscopic versus open gastrectomy for gastric cancer, a multicenter prospectively randomized controlled trial (LOGICA-trial)
- Author
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Haverkamp, L. (Leonie), Brenkman, H.J.F. (Hylke J.F.), Seesing, M.F.J. (Maarten), Gisbertz, S.S. (Suzanne S.), Berge Henegouwen, M.I. (Mark) van, Luyer, M. (Misha), Nieuwenhuijzen, G.A.P. (Gerard), Wijnhoven, B.P.L. (Bas), Lanschot, J.J.B. (Jan) van, de Steur, W.O. (Wobbe O.), Hartgrink, H.H. (H.), Stoot, J.H.M.B. (Jan), Hulsewé, K.W.E. (Karel W.E.), Spillenaar Bilgen, E.J. (Ernst Jan), Rütter, J.E. (Jeroen E.), Kouwenhoven, E.A. (Ewout), van Det, M.J. (Marc J.), Peet, D.L. (Donald) van der, Daams, F. (Freek), Draaisma, W.A. (Werner), Broeders, I.A.M.J. (Ivo), Stel, H.F. (Henk) van, Lacle, M.M. (Miangela M.), Ruurda, J.P. (Jelle), Hillegersberg, R. (Richard) van, Haverkamp, L. (Leonie), Brenkman, H.J.F. (Hylke J.F.), Seesing, M.F.J. (Maarten), Gisbertz, S.S. (Suzanne S.), Berge Henegouwen, M.I. (Mark) van, Luyer, M. (Misha), Nieuwenhuijzen, G.A.P. (Gerard), Wijnhoven, B.P.L. (Bas), Lanschot, J.J.B. (Jan) van, de Steur, W.O. (Wobbe O.), Hartgrink, H.H. (H.), Stoot, J.H.M.B. (Jan), Hulsewé, K.W.E. (Karel W.E.), Spillenaar Bilgen, E.J. (Ernst Jan), Rütter, J.E. (Jeroen E.), Kouwenhoven, E.A. (Ewout), van Det, M.J. (Marc J.), Peet, D.L. (Donald) van der, Daams, F. (Freek), Draaisma, W.A. (Werner), Broeders, I.A.M.J. (Ivo), Stel, H.F. (Henk) van, Lacle, M.M. (Miangela M.), Ruurda, J.P. (Jelle), and Hillegersberg, R. (Richard) van
- Abstract
Background: For gastric cancer patients, surgical resection with en-bloc lymphadenectomy is the cornerstone of curative treatment. Open gastrectomy has long been the preferred surgical approach worldwide. However, this procedure is associated with considerable morbidity. Several meta-analyses have shown an advantage in short-term outcomes of laparoscopic gastrectomy compared to open procedures, with similar oncologic outcomes. However, it remains unclear whether the results of these Asian studies can be extrapolated to the Western population. In this trial from the Netherlands, patients with resectable gastric cancer will be randomized to laparoscopic or open gastrectomy. Methods: The study is a non-blinded, multicenter, prospectively randomized controlled superiority trial. Patients (≥18 years) with histologically proven, surgically resectable (cT1-4a, N0-3b, M0) gastric adenocarcinoma and European Clinical Oncology Group performance status 0, 1 or 2 are eligible to participate in the study after obtaining informed consent. Patients (n = 210) will be included in one of the ten participating Dutch centers and are randomized to either laparoscopic or open gastrectomy. The primary outcome is postoperative hospital stay (days). Secondary outcome parameters include postoperative morbidity and mortality, oncologic outcomes, readmissions, quality of life and cost-effectiveness. Discussion: In this randomized controlled trial laparoscopic and open gastrectomy are compared in patients with resectable gastric cancer. It is expected that laparoscopic gastrectomy will result in a faster recovery of the patient and a shorter hospital stay. Secondly, it is expected that laparoscopic gastrectomy will be associated with a lower postoperative morbidity, less readmissions, higher cost-effectiveness, better postoperative quality of life, but with similar mortality and oncologic outcomes, compared to open gastrectomy. The study started on 1 December 2014. Inclusion and follow-up will
- Published
- 2015
- Full Text
- View/download PDF
30. Long-term quality of life after oesophagectomy with gastric conduit interposition for cancer
- Author
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Akkerman, R D L, Haverkamp, L, van Rossum, P S N, van Hillegersberg, R, Ruurda, J P, Akkerman, R D L, Haverkamp, L, van Rossum, P S N, van Hillegersberg, R, and Ruurda, J P
- Published
- 2015
31. Esophageal and Gastric Cancer Pearl: a nationwide clinical biobanking project in the Netherlands
- Author
-
MS CGO, MS MDL 1, Infection & Immunity, Cancer, MS MDL Oncologie, Divisie Beeld & Oncologie, Other research (not in main researchprogram), Haverkamp, L, Parry, K, van Berge Henegouwen, M I, van Laarhoven, H W, Bonenkamp, J J, Bisseling, T M, Siersema, P D, Sosef, M N, Stoot, J H, Beets, G L, de Steur, W O, Hartgrink, H H, Verspaget, H W, van der Peet, D L, Plukker, J T, van Etten, B, Wijnhoven, B P L, van Lanschot, J J, van Hillegersberg, R, Ruurda, J P, MS CGO, MS MDL 1, Infection & Immunity, Cancer, MS MDL Oncologie, Divisie Beeld & Oncologie, Other research (not in main researchprogram), Haverkamp, L, Parry, K, van Berge Henegouwen, M I, van Laarhoven, H W, Bonenkamp, J J, Bisseling, T M, Siersema, P D, Sosef, M N, Stoot, J H, Beets, G L, de Steur, W O, Hartgrink, H H, Verspaget, H W, van der Peet, D L, Plukker, J T, van Etten, B, Wijnhoven, B P L, van Lanschot, J J, van Hillegersberg, R, and Ruurda, J P
- Published
- 2015
32. Prophylactic Laparoscopic Total Gastrectomy with Jejunal Pouch Reconstruction in Patients Carrying a CDH1 Germline Mutation
- Author
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Genetica Sectie Oncogenetica, Child Health, Cancer, MS CGO, Heelkunde Opleiding, Zorglijn GE/ONCO Medisch, MS MDL 1, Infection & Immunity, Other research (not in main researchprogram), Haverkamp, L., van der Sluis, P. C., Ausems, M. G E M, van der Horst, S., Siersema, P. D., Ruurda, J. P., Offerhaus, G. J A, van Hillegersberg, R., Genetica Sectie Oncogenetica, Child Health, Cancer, MS CGO, Heelkunde Opleiding, Zorglijn GE/ONCO Medisch, MS MDL 1, Infection & Immunity, Other research (not in main researchprogram), Haverkamp, L., van der Sluis, P. C., Ausems, M. G E M, van der Horst, S., Siersema, P. D., Ruurda, J. P., Offerhaus, G. J A, and van Hillegersberg, R.
- Published
- 2015
33. Surgical treatment of adenocarcinomas of the gastro-esophageal junction
- Author
-
MS CGO, MS Radiologie, MS MDL 1, Cancer, MS MDL Oncologie, Other research (not in main researchprogram), Divisie Beeld & Oncologie, Parry, K, Haverkamp, L, Bruijnen, R C G, Siersema, P D, Ruurda, J P, van Hillegersberg, R, MS CGO, MS Radiologie, MS MDL 1, Cancer, MS MDL Oncologie, Other research (not in main researchprogram), Divisie Beeld & Oncologie, Parry, K, Haverkamp, L, Bruijnen, R C G, Siersema, P D, Ruurda, J P, and van Hillegersberg, R
- Published
- 2015
34. Long-term quality of life after oesophagectomy with gastric conduit interposition for cancer
- Author
-
MS CGO, Fysica Radiotherapie Research, Cancer, Divisie Beeld & Oncologie, Other research (not in main researchprogram), Akkerman, R D L, Haverkamp, L, van Rossum, P S N, van Hillegersberg, R, Ruurda, J P, MS CGO, Fysica Radiotherapie Research, Cancer, Divisie Beeld & Oncologie, Other research (not in main researchprogram), Akkerman, R D L, Haverkamp, L, van Rossum, P S N, van Hillegersberg, R, and Ruurda, J P
- Published
- 2015
35. Oncologic Long-Term Results of Robot-Assisted Minimally Invasive Thoraco-Laparoscopic Esophagectomy with Two-Field Lymphadenectomy for Esophageal Cancer
- Author
-
Heelkunde Opleiding, MS CGO, Other research (not in main researchprogram), Cancer, Zorglijn GE/ONCO Medisch, MS MDL 1, Infection & Immunity, MS MDL Oncologie, Pathologie Pathologen staf, Pathologie, van der Sluis, P. C., Ruurda, J. P., Verhage, R. J J, van der Horst, S., Haverkamp, L., Siersema, P. D., Borel Rinkes, I. H M, ten Kate, F. J W, van Hillegersberg, R., Heelkunde Opleiding, MS CGO, Other research (not in main researchprogram), Cancer, Zorglijn GE/ONCO Medisch, MS MDL 1, Infection & Immunity, MS MDL Oncologie, Pathologie Pathologen staf, Pathologie, van der Sluis, P. C., Ruurda, J. P., Verhage, R. J J, van der Horst, S., Haverkamp, L., Siersema, P. D., Borel Rinkes, I. H M, ten Kate, F. J W, and van Hillegersberg, R.
- Published
- 2015
36. Laparoscopic versus open gastrectomy for gastric cancer, a multicenter prospectively randomized controlled trial (LOGICA-trial)
- Author
-
Haverkamp, L, Brenkman, HJF, Seesing, MFJ, Gisbertz, SS, Henegouwen, MIVB, Luyer, MDP, Nieuwenhuijzen, GAP, Wijnhoven, Bas, van Lanschot, Jan, de Steur, WO, Hartgrink, HH, Stoot, JHMB, Hulsewe, KWE, Bilgen, EJS, Rutter, JE, Kouwenhoven, EA, van Det, MJ, van der Peet, DL, Daams, F, Draaisma, WA, Broeders, IAMJ, van Stel, HF, Lacle, MM, Ruurda, JP, van Hillegersberg, R, Haverkamp, L, Brenkman, HJF, Seesing, MFJ, Gisbertz, SS, Henegouwen, MIVB, Luyer, MDP, Nieuwenhuijzen, GAP, Wijnhoven, Bas, van Lanschot, Jan, de Steur, WO, Hartgrink, HH, Stoot, JHMB, Hulsewe, KWE, Bilgen, EJS, Rutter, JE, Kouwenhoven, EA, van Det, MJ, van der Peet, DL, Daams, F, Draaisma, WA, Broeders, IAMJ, van Stel, HF, Lacle, MM, Ruurda, JP, and van Hillegersberg, R
- Abstract
Background: For gastric cancer patients, surgical resection with en-bloc lymphadenectomy is the cornerstone of curative treatment. Open gastrectomy has long been the preferred surgical approach worldwide. However, this procedure is associated with considerable morbidity. Several meta-analyses have shown an advantage in short-term outcomes of laparoscopic gastrectomy compared to open procedures, with similar oncologic outcomes. However, it remains unclear whether the results of these Asian studies can be extrapolated to the Western population. In this trial from the Netherlands, patients with resectable gastric cancer will be randomized to laparoscopic or open gastrectomy. Methods: The study is a non-blinded, multicenter, prospectively randomized controlled superiority trial. Patients (>= 18 years) with histologically proven, surgically resectable (cT1-4a, N0-3b, M0) gastric adenocarcinoma and European Clinical Oncology Group performance status 0, 1 or 2 are eligible to participate in the study after obtaining informed consent. Patients (n = 210) will be included in one of the ten participating Dutch centers and are randomized to either laparoscopic or open gastrectomy. The primary outcome is postoperative hospital stay (days). Secondary outcome parameters include postoperative morbidity and mortality, oncologic outcomes, readmissions, quality of life and cost-effectiveness. Discussion: In this randomized controlled trial laparoscopic and open gastrectomy are compared in patients with resectable gastric cancer. It is expected that laparoscopic gastrectomy will result in a faster recovery of the patient and a shorter hospital stay. Secondly, it is expected that laparoscopic gastrectomy will be associated with a lower postoperative morbidity, less readmissions, higher cost-effectiveness, better postoperative quality of life, but with similar mortality and oncologic outcomes, compared to open gastrectomy. The study started on 1 December 2014. Inclusion and follow-up wil
- Published
- 2015
37. Acuut nierfalen door vergiftiging met gordijnzwam
- Author
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Bouhbouh, S., Haverkamp, L., Kuyper, T.W., Wolff, F.A., and Barendregt, J.N.M.
- Subjects
Life Science ,Soil Biology ,PE&RC ,Bodembiologie - Abstract
Achtergrond Inname van bepaalde soorten gordijnzwammen kan leiden tot nierfalen. In Nederland is deze paddenstoelvergiftiging niet eerder beschreven. Casus Een 58-jarige vrouw presenteerde zich met hoofdpijn, braken en afnemende urineproductie, voorafgegaan door enkele dagen met pijnlijke, branderige dorst en malaise. Er was sprake van acuut en irreversibel nierfalen zonder bekende achterliggende aandoening. Volgens de anamnese had zij 2 dagen voor de eerste ziekteverschijnselen ragout gegeten met in het bos geplukte paddenstoelen. In een nierbiopt werd een interstitiële nefritis met necrose van proximale tubuli vastgesteld. In een restant van de ragout werden 2 fragmenten gevonden van een gordijnzwam, waarschijnlijk behorend tot het complex Cortinarius cinnamomeus (kaneelkleurige gordijnzwam). De eerste symptomen en het beloop passen bij vergiftiging door Cortinarius zoals beschreven in de literatuur. Ondanks hemodialyse en toediening van acetylcysteïne en glucocorticoïden herstelde haar nierfunctie niet. Conclusie Deze casus is de eerst beschreven paddenstoelvergiftiging met een gordijnzwam (Cortinarius sp.) in Nederland.
- Published
- 2011
38. Long-term quality of life after oesophagectomy with gastric conduit interposition for cancer
- Author
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Akkerman, R.D.L., primary, Haverkamp, L., additional, van Rossum, P.S.N., additional, van Hillegersberg, R., additional, and Ruurda, J.P., additional
- Published
- 2015
- Full Text
- View/download PDF
39. Early Development of Behavior and the Nervous System
- Author
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Oppenheim, R. W., primary and Haverkamp, L., additional
- Published
- 1986
- Full Text
- View/download PDF
40. 40. Not the type of surgical treatment but neoadjuvant treatment influences overall survival in patients with gastro-oesophageal junction tumours in the Netherlands
- Author
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Koëter, M., primary, Haverkamp, L., additional, Perry, K., additional, Verhoeven, R.H., additional, Lemmens, V.E.P.P., additional, Ruurda, J.P., additional, Luyer, M.D.P., additional, Van Hillegersberg, R., additional, and Nieuwenhuijzen, G.A.P., additional
- Published
- 2014
- Full Text
- View/download PDF
41. Surgical Treatment of Adenocarcinomas of the Gastro-esophageal Junction
- Author
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Parry, K., primary, Haverkamp, L., additional, Bruijnen, R. C. G., additional, Siersema, P. D., additional, Ruurda, J. P., additional, and van Hillegersberg, R., additional
- Published
- 2014
- Full Text
- View/download PDF
42. Oncologic Long-Term Results of Robot-Assisted Minimally Invasive Thoraco-Laparoscopic Esophagectomy with Two-Field Lymphadenectomy for Esophageal Cancer.
- Author
-
Sluis, P., Ruurda, J., Verhage, R., Horst, S., Haverkamp, L., Siersema, P., Borel Rinkes, I., Kate, F., and Hillegersberg, R.
- Abstract
Background: Open transthoracic esophagectomy is the worldwide gold standard in the treatment of resectable esophageal cancer. Robot-assisted minimally invasive thoraco-laparoscopic esophagectomy (RAMIE) for esophageal cancer may be associated with reduced blood loss, shorter intensive care unit (ICU) stay, and less cardiopulmonary morbidity; however, long-term oncologic results have not been reported to date. Methods: Between June 2007 and September 2011, a total of 108 patients with potentially resectable esophageal cancer underwent RAMIE at the University Medical Centre Utrecht, with curative intent. All data were recorded prospectively. Results: Median duration of the surgical procedure was 381 min (range 264-636). Pulmonary complications were most common and were observed in 36 patients (33 %). Median ICU stay was 1 day, and median overall postoperative hospital stay was 16 days. In-hospital mortality was 5 %. The majority of patients (78 %) presented with T3 and T4 disease, and 68 % of patients had nodal-positive disease (cN1-3). In 65 % of patients, neoadjuvant treatment (chemotherapy 57 %, chemoradiotherapy 7 %, radiotherapy 1 %) was administered, and in 103 (95 %) patients, a radical resection (R0) was achieved. The median number of lymph nodes was 26, median follow-up was 58 months, 5-year overall survival was 42 %, median disease-free survival was 21 months, and median overall survival was 29 months. Tumor recurrence occurred in 51 patients and was locoregional only in 6 (6 %) patients, systemic only in 31 (30 %) patients, and combined in 14 (14 %) patients. Conclusion: RAMIE was shown to be oncologically effective, with a high percentage of R0 radical resections and adequate lymphadenectomy. RAMIE provided good local control with a low percentage of local recurrence at long-term follow up. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
43. The value of database controls in pilot or futility studies in ALS
- Author
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Czaplinski, A., primary, Haverkamp, L. J., additional, Yen, A. A., additional, Simpson, E. P., additional, Lai, E. C., additional, and Appel, S. H., additional
- Published
- 2006
- Full Text
- View/download PDF
44. Prevalence and correlates of neuropsychological deficits in amyotrophic lateral sclerosis.
- Author
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Massman, P J, primary, Sims, J, additional, Cooke, N, additional, Haverkamp, L J, additional, Appel, V, additional, and Appel, S H, additional
- Published
- 1996
- Full Text
- View/download PDF
45. The HHQK domain of beta-amyloid provides a structural basis for the immunopathology of Alzheimer's disease.
- Author
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Giulian, D, Haverkamp, L J, Yu, J, Karshin, W, Tom, D, Li, J, Kazanskaia, A, Kirkpatrick, J, and Roher, A E
- Abstract
The beta-amyloid peptide 1-42 (Abeta1-42), a major component of neuritic and core plaques found in Alzheimer's disease, activates microglia to kill neurons. Selective modifications of amino acids near the N terminus of Abeta showed that residues 13-16, the HHQK domain, bind to microglial cells. This same cluster of basic amino acids is also known as a domain with high binding affinity for heparan sulfate. Both Abeta binding to microglia and Abeta induction of microglial killing of neurons were sensitive to heparitinase cleavage and to competition with heparan sulfate, suggesting membrane-associated heparan sulfate mediated plaque-microglia interactions through the HHQK domain. Importantly, small peptides containing HHQK inhibited Abeta1-42 cell binding as well as plaque induction of neurotoxicity in human microglia. In vivo experiments confirmed that the HHQK peptide reduces rat brain inflammation elicited after infusion of Abeta peptides or implantation of native plaque fragments. Strategies which exploit HHQK-like agents may offer a specific therapy to block plaque-induced microgliosis and, in this way, slow the neuronal loss and dementia of Alzheimer's disease.
- Published
- 1998
46. Behavioral development in the absence of neural activity: effects of chronic immobilization on amphibian embryos
- Author
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Haverkamp, L. J. and Oppenheim, R. W.
- Subjects
animal structures ,embryonic structures - Abstract
Embryos of Xenopus laevis and Ambystoma mexicanum were continually immobilized from premotile stages of development to stages at which normally reared embryos were swimming well. Immobilization was achieved through exposure to solutions of chloretone, lidocaine, or alpha- bungarotoxin. At a number of stages after recovery from the drugs, spontaneous and stimulated behaviors were extensively quantified. Immobilization of Ambystoma embryos resulted in temporary defects in musculoskeletal development. In contrast, treated Xenopus embryos could not be distinguished from controls by simple visual observation within minutes to hours after removal from the drug solutions. Quantifications of behavior revealed, however, a transient period of 24–48 hr during which treated embryos exhibited consistently reduced measures of stimulated swimming, while showing an increase in frequency of spontaneous movements. Detailed behavioral testing could detect no permanent effects of chronic immobilization in either species after this initial period of recovery. The results are discussed in reference to the classic works of Harrison (1904), Carmichael (1926, 1927), and Matthews and Detwiler (1926).
- Published
- 1986
- Full Text
- View/download PDF
47. Robot-assisted minimally invasive thoraco-laparoscopic esophagectomy versus open transthoracic esophagectomy for resectable esophageal cancer, a randomized controlled trial (ROBOT trial)
- Author
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van der Sluis Pieter C, Ruurda Jelle P, van der Horst Sylvia, Verhage Roy JJ, Besselink Marc GH, Prins Margriet JD, Haverkamp Leonie, Schippers Carlo, Rinkes Inne HM Borel, Joore Hans CA, ten Kate Fiebo JW, Koffijberg Hendrik, Kroese Christiaan C, van Leeuwen Maarten S, Lolkema Martijn PJK, Reerink Onne, Schipper Marguerite EI, Steenhagen Elles, Vleggaar Frank P, Voest Emile E, Siersema Peter D, and van Hillegersberg Richard
- Subjects
Medicine (General) ,R5-920 - Abstract
Abstract Background For esophageal cancer patients, radical esophagolymphadenectomy is the cornerstone of multimodality treatment with curative intent. Transthoracic esophagectomy is the preferred surgical approach worldwide allowing for en-bloc resection of the tumor with the surrounding lymph nodes. However, the percentage of cardiopulmonary complications associated with the transthoracic approach is high (50 to 70%). Recent studies have shown that robot-assisted minimally invasive thoraco-laparoscopic esophagectomy (RATE) is at least equivalent to the open transthoracic approach for esophageal cancer in terms of short-term oncological outcomes. RATE was accompanied with reduced blood loss, shorter ICU stay and improved lymph node retrieval compared with open esophagectomy, and the pulmonary complication rate, hospital stay and perioperative mortality were comparable. The objective is to evaluate the efficacy, risks, quality of life and cost-effectiveness of RATE as an alternative to open transthoracic esophagectomy for treatment of esophageal cancer. Methods/design This is an investigator-initiated and investigator-driven monocenter randomized controlled parallel-group, superiority trial. All adult patients (age ≥18 and ≤80 years) with histologically proven, surgically resectable (cT1-4a, N0-3, M0) esophageal carcinoma of the intrathoracic esophagus and with European Clinical Oncology Group performance status 0, 1 or 2 will be assessed for eligibility and included after obtaining informed consent. Patients (n = 112) with resectable esophageal cancer are randomized in the outpatient department to either RATE (n = 56) or open three-stage transthoracic esophageal resection (n = 56). The primary outcome of this study is the percentage of overall complications (grade 2 and higher) as stated by the modified Clavien–Dindo classification of surgical complications. Discussion This is the first randomized controlled trial designed to compare RATE with open transthoracic esophagectomy as surgical treatment for resectable esophageal cancer. If our hypothesis is proven correct, RATE will result in a lower percentage of postoperative complications, lower blood loss, and shorter hospital stay, but with at least similar oncologic outcomes and better postoperative quality of life compared with open transthoracic esophagectomy. The study started in January 2012. Follow-up will be 5 years. Short-term results will be analyzed and published after discharge of the last randomized patient. Trial registration Dutch trial register: NTR3291 ClinicalTrial.gov: NCT01544790
- Published
- 2012
- Full Text
- View/download PDF
48. Apolipoprotein E epsilon 4 in bulbar-onset motor neuron disease.
- Author
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Smith, R G, Haverkamp, L J, Case, S, Appel, V, and Appel, S H
- Subjects
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AGE factors in disease , *ALLELES , *APOLIPOPROTEINS , *MOTOR neuron diseases , *GENOTYPES - Published
- 1996
- Full Text
- View/download PDF
49. BJS commission on surgery and perioperative care post-COVID-19
- Author
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E. Abahuje, A. Abbas, M. Abd El Aziz Abd El Maksoud, A. Abdelhady, S. Abdelhamid, H. Abdelkarem Ahmed Faraj, B. Abdelqader, T. Abdelrahman, H. Abdou, A. Abdullah, M. Abedua Harrison, E. Abem Owusu, A. Aboalazayem, R. Aboulhosn, S. Abu Oda, A. Abubakar, A. Abutaka, D. Acevedo Fontalvo, S. Acuna, A. Adefemi, S. Adegbola, T. Adenuga, A. Adeyeye, A. Adil Hilmi, A. Adisa, K. Aditya, T. Adjeso, R. Aftab, A. Afzal, V. Aggarwal, A. Aggarwal, R. Aguilera, M. -L. Aguilera-Are´valo, E. J. Aguirre Salamanca, I. Aguirre-Allende, D. Ahari, H. Ahmad, F. Ahmad Rauf, A. Ahmad Zartasht Khan, S. Ahmed, N. Ahmed Fieturi, S. Ahmed Mohamed, Z. Ahmed-Bakhsh, M. Ahsan Javed, L. Akano, A. Akbar, M. Akhbari, P. Akhmedov, G. Aksit, Y. Akula, A. S. Alagaratnam, S. Al Majid, O. Al Mukhtar, H. Al Omran, N. AlAsali, M. Al-Azzawi, R. Al-Habsi, H. Al-Iraqi, H. Al-Naggar, E. Alameer, H. Albirnawi, D. Alderson, F. Aldulaijan, R. Alejandro Miranda Ojeda, A. AlHasan, S. Ali, A. Ali, M. Ali Khan, Y. Alimova, F. Aljanadi, R. Aljubure, N. Allopi, H. Almedbal, M. Almubarak, Z. Alqaidoom, N. Alselaim, M. Alshaar, R. Alshammari, K. Altaf, S. Altıner, B. Altunpak, L. A. Alvarez Lozada, E. Amal Nahal, A. Amer, K. Amin, U. Aminu, N. Amisi Numbi, T. Amjad, R. Amoah, Y. An, N. -A. Anastasopoulos, J. Andre´s Urrutia, F. Angarita, K. -L. Angarita, M. A´ ngel FreirI´a Eiras, A. Antypas, M. A. Anwar, H. Anwar, T. O. Apampa, K. Apostolou, C. Aquina, R. Arachchige Adithi Himika Randeni, M. I. Archila Godı´nez, O. Arez, A. A. Arezzo, P. Armonis, S. Arshad, M. Arshad Salman, A. Arshid, P. C. Arteaga Asensio, T. Arthur, A. Arumuga Jothi, F. Aryo Damara, L. Asensio Gomez, J. Ashcroft, S. Ashraf, A. Asif, M. Atif, M. Attaullah Khan, N. Avellaneda, S. Awad, M. Awadh, A. Axiaq, A. Ayad Mohammed Shuwayyah, D. Ayalew, E. Aytac, F. Azam, J. Azevedo, B. Azhar, J. Aziz, A. Aziz, A. Azzam, A. Baba Ndajiwo, M. Baig, D. Baker, F. Bakko, R. Balachandran, G. Balachandran, J. Balagizi Mudekereza, E. Balai, B. Balci, A. Balduzzi, A. Balhareth, S. Bandyopadhyay, D. Banerjee, D. Bangalore Mahalinga, B. Bankhead-Kendall, N. D. A. Bankole, V. Banwell, F. Baris Bengur, B. Baris Ozmen, M. Barnard, R. Barnett, J. A. Barreras Espinoza, A. Barrios, G. Bass, M. Bass, A. Bausys, A. Bavikatte, J. Bayram, M. Belousov, A. G. Berardi, A. Beamish, C. Beattie, F. Belia, V. Bellato, S. Bellikatti, S. Benjamens, C. Benlice, S. Bennedsgaard, S. Bennett, Z. Bentounsi, H. Bergenfeldt, A. Bergenfelz, M. Besselink, G. Bhandoria, E. Bhangu, M. Bhatia, M. T. Bhatti, Z. Bilgili, G. Bislenghi, C. Bisset, S. Biswas, J. Blake, R. Blanco, L. Boccalatte, R. Boden, C. Bojanic, M. Boland, P. Boland, E. Bollen, E. -A. Bonci, L. Boni, A. Booth, R. Booth, A. Borakati, G. E. Borunda Escudero, S. J. Bosco, P. Bostro¨ m, P. Botelho de Alencar Ferreira Cruz, K. Bouchagier, A. Bouhuwaish, M. Boutros, K. Boyce, C. Boyle, L. Bradshaw, A. Brandl, A. Brar, G. Brat, H. Brenkman, C. Brennan, C. Brines, A. Brookmyre, C. Brosnan, L. Brouwers, A. Brown, L. Brown, C. Brown, J. Brown, V. BS, M. Buksh, M. Bunani Emmanuel, D. Burbano, A. Burelli, A. Burke, J. Burke, N. Burlov, A. Burns, O. Burton, A. Butt, B. Buzra Ozkan, L. Cabrera Silva, E. Y. Caicedo, T. Calderbank, W. Cambridge, G. Campelo, O. Can Tatar, F. Carbone, F. Carrano, D. Casallas, D. Casanova Portoles, F. Casciani, I. Cassimjee, O. A. Castaneda Ramı´rez, V. Catala´ n, J. Caviedes, L. Cayetano, M. ~ Ceresoli, M. Chan, V. Chan, P. Chandrasinghe, S. Chapman, A. Chaturvedi, D. Chaudhry, H. Chaudry, H. W. Chen, A. Cheng, M. Chernykh, A. M. Cherrie, I. Cheruiyot, J. Cheung, C. Chia, J. Chica, N. Chinai, A. Chirwa, J. Chiwaligo, A. Choi, J. Choi, M. R. Chowdhury, E. Christopher, N. Christou, T. Chu, D. Chua, H. W. Chua, C. Chung, A. Cihat Yildirim, M. Cillo, S. Cioffi, H. Claireaux, S. Clermonts, R. Clifford, M. Climent, A. Clynch, R. -J. Coelen, E. Cola´ s-Ruiz, A. Collar, M. Collard, K. C. Conlon, T. Connelly, K. Connor, J. A. Cook, T. Correia de Sa´, N. Cos¸gun Acar, T. Costa, D. Couch, S. Cowper, B. Creavin, B. Crook, A. Curell, R. D’alessio, J. Dale, J. Damgaard Eriksen, I. Dario Martin Gonzalez, A. Darwish, M. Das, R. Das, K. Das, R. Dave, S. O. David, T. Davies, C. Davis, S. Davison, V. Davletshina, A. Dawidziuk, A. Dawson, M. de Andres Crespo, H. de Berker, P. de Dieu Ngo, E. Dekker, R. de la Caridad Espinosa Luis, B. de Lacy, N. Demartines, A. de Montserrat Medina Sifuentes, S. De Silva, C. del Rio, V. Delaune, A. Dell, I. Demirbas¸, S. Demirli Atici, M. Deniz Tepe, M. Derebey, G. Desai, M. Desai, S. Devarakonda, N. Deveras, G. Di Franco, M. Di Martino, F. Di Marzo, A´ . Dı´az, G. Diaz del Gobbo, C. DiazCastrillon, L. Dick, K. Dickinson, E. Diego, I. Dimasi, A. Ding, S. Dingemans, L. Dixon, B. Dixon, W. Doherty, D. Dooreemeah, C. Donohue, M. Dornseifer, F. Dossa, W. Dossou, T. Drake, I. Drami, G. Drevin, M. C. du Plessis, N. Dudi-Venkata, R. Dudley, S. Duffy, D. Duklas, B. -D. Dumbrava, F. Duygu Avlar, A. Dworzynska, W. Ebrahim, A. Ebrahim, E. Efre´n Lozada Herna´ ndez, N. Ehigie, M. El Boghdady, C. El Hasnaoui, M. El Sheikh, A. El-Hussuna, O. Eldurssi, H. Elfeki, M. Elhadi, M. Elhassan, A. Elhissi, B. Elliot, C. Elsenbroek, B. Elsolh, N. Elson, H. Eltyeb, H. Emerson, S. H. Emile, G. Endalle, W. English, C. Ercisli, G. Espinosa, M. Essam Abdelraheem, H. Essangri, P. Etienne, M. D. Evans, T. Evans, C. Ezeme, F. Ezzahraa, T. Fadalla, J. Fagan, M. Fahmy, C. Fairfield, O. Falade, S. Famularo, F. Faqar-Uz-Zaman, Y. Farid, A. Farooq, H. Farooq, F. Farooqui, B. Farquharson, A. Faruqi, R. Faulder, M. Faut, K. Fechner, T. Feenstra, M. Fehervari, L. Fernandez, J. Ferna´ ndez Alberti, L. Ferrario, D. Field, L. Fiore, S. Fingerhut, S. Finlayson, N. Fleming, C. Fleming, E. Florial, M. Fok, D. Fokin, M. Foley, M. P. Forero, T. Forgan, M. Fornasiero, H. Fowler, G. Fowler, E. Franchi, L. Franklin, A˚ . Fredriksson, P. Fruhling, G. Fuentes Navarrette, A. Fu¨ lo¨ p, M. Furtado, T. Gaarder, N. Galbraith, I. T. K. Gallagher, G. Gallo, T. Gana, E. Gaskin, M. Gasparini, R. G. Gatan, E. Geary, K. Gelaye Wudineh, G. Gemenetzis, M. Georgi, H. Ghalige, W. Ghareeb, T. Ghatwary Tantawy, C. Ghomsi, A. Ghuman, P. Giannakis, F. Giron, K. Gjengedal, E. Gkotsis, J. Glasbey, S. Godahewa, D. Godula, P. Goffredo, S. Goh, M. Golriz, L. Gomez, D. Gomez Gomez, R. Gonzalez, D. Gonzalez, E. Gonzalez Gutierrez, D. Gopar, L. Gordini, A. Gori, S. Gorta´ zar, N. Gousy, R. Gowda, M. Gowda, J. Gqada, M. Grechenig, J. Greer, L. Grego´ rio, A. Grigorova, H. Grimes, V. Groot, R. C. Grossman, R. Gruber, A. Gru¨ ter, R. Guest, R. Gujjuri, E. Gu¨ lc¸ek, B. Gulcu, K. Gull, M. Gulmez, V. Gupta, A. Gutlic, T. Guven, T. Gwatirisa, G. Gwini, P. Gwodog, S. Gysling, M. Habib, A. B. Hafeez Bhatti, J. Hallesmith, S. Halloran, M. Hamza Sadiq, C. Haney, N. Hanna, L. Hanna, M. Hannington, J. Harbjerg, D. Haribaskaran, N. Harran, B. Harrington, E. Harrison, R. Hasan, S. Hashmi, M. Hassan, A. Hassan, L. Haverkamp, S. Hazen, B. Heer, J. Heil, J. Helliwell, N. Henriksen, D. Henshall, M. Hermanson, S. Hermena, D. Hettiarachchi, C. Hextall, M. Hidalgo, H. Hidayat, A. Hider, P. Higgins, R. Hinchliffe, D. Hirani, D. Hirpara, I. Hisham, M. Hite, S. M. Hoh, C. Holmberg, E. Ho¨ lmich, F. Holst, A. Hossam, A. Hossam Elfallal, P. Howard, E. Huaman, Y. Huang, L. Huang, D. Huang, T. Huber, J. Hugh, J. Hughes, F. Hu¨ ttner, R. Huynh, A. Hylands, J. Iannuzzi, B. Ielpo, A. Iftikhar Talib, J. Ignacio, P. Ignatavicius, S. Ike, C. Ikwu, M. Inama, A. Ing, A. Ingels, A. Isik, N. Islam, I. J. Ives, A. J. M. S. AlHasan, C. J. Perez Rivera, F. Ja´ come, T. Jaffer, O. Jagiella-Lodise, M. Jain, K. Jain, M. Jakubauskas, M. Jalal, H. James, Y. Jang, B. Janssen, H. Jansson, U´ . Jariod-Ferrer, H. Javanmard, S. Javed, U. Jayarajah, I. Jayasuriya, J. Je, Z. Jessop, E. Jia Lin Tang, H. Jiang, Y. Jiayan, T. Jih Huei, R. Jimenez-Rodriguez, D. Joh, A. Johnson, N. Jones, C. Jones, C. Jordan, J. Jose´ Nu´ nez Ju, ~ M. Jose´ Pizarro, C. Jose Salazar J. Joseph, C. Justiniano, T. Kabir, M. Kadhum, C. Kalfountzos, E. Kalogiannaki, K. Kalyanasundaram, S. Kamarajah, M. Kamil Quraishi, Y. Kanemitsu, A. Kapila, V. Kapila, G. Karagiannidis, M. Kashif, S. Kathiravelupillai, A. Kathiravelupillai, E. Katsogridakis, K. Kaur, H. Kaur Sekhon Inderjit Singh, N. Kausur, M. Kawka, G. Keehan, S. Kehlet Watt, M. Kelly, M. E. Kelly, I. Kelvin Egbuchulem, G. Kembuan, E. Khajeh, A. Khaled Elfaitur, M. F. Khan, S. Khan, M. Khan, D. Khan, H. Khan, H. Khatkar, E. Khatkov, R. Khaw, B. Kim, K. Kishore Siddiraju, D. Kitua, B. Kırımtay, S. Kmezic, S. Knight, T. Koe¨ter, A. Koh, F. Koh Hong Xiang, T. Kojo Anyomih, A. I. N. Kok, R. Kokelaar, I. Koliarakis, S. Kolli, J. Kong, D. Ko¨ nig, M. otze, A. Kourdouli, M. Kowal, A. Kraima, F. Kramer, M. Kryzauskas, I. Kuchynskyi, C. Kuemmerli, S. Kuiper, S. Kumar, A. Kumar, L. Kumar, H. Kumar, N. Kumar, S. Kumar Bandyopadhyay, P. Kumar Garg, S. Kumar Venkatappa, J. Kung, S. Kural, A. Kushairi, E. Kuuzie, M. Kvietkauskas, I. Kwek, J. La, L. Lai, S. Lakpriya, K. Lam, M. Lami, I. Lansdorp-Vogelaar, P. Lapolla, H. Larsen, J. Latif, U. Laudari, A. Laurnezi, A. Lawal, S. Lawday, H. Lederhuber, A. Lednev, R. Lee, M. E. van Leerdam, G. Lefevbre, M. Lesmus, F. A. Leyva Moraga, E. Leyva Moraga, F. Leyva Moraga, H. L. Li, A. Li, Z. Li, E. Licardie, A. Light, A. L. Lightner, A. Lin, E. Lincango, F. Litta, H. Liu, B. Lofthouse, M. A. Londono, R. Lopes, R. Lopes de Freitas, L. Lopez, A. I. Lo´ pez, J. ~ Lopez-Gomez, G. Lopez-Pena, R. Lowe, D. Lowe, M. Lowey, G. Loy, V. Lozanovski, J. Luzon, P. Lynn, T. Maccabe, A. Machielsen, C. A. Mafla Herrerı´a, L. Maggino, K. Mahawar, D. Mahmood, M. Mahmoud, K. Mahtani, I. Maitra, S. Maji, I. Majiet, L. Mal, J. Malherbe, K. Malhotra, P. Malkomes, E. Man, A. Manan Sheikh, S. Manjunath, R. Manzano Nunez, S. Manzoor, R. Maqsood, G. ~ Marchegiani, F. Marchegiani, D. Marı´n, A. Marin, I. Marks, E. Marson, A. Martensen, D. Martin, G. Martı´n Martı´n, B. Martin-Perez, P. Martinez, P. Marwaha, C. Mashauri, H. Mashbari, Ł. Masior, R. Masri, L. Masud, S. Masudi, G. Mateu Calabuig, S. Math, A. Matrachisia, J. Mayol, D. Mazingi, A. Mazzotta, J. McAlinden, G. McCabe, L. McColm, H. McElvaney, K. McGivern, J. McGovern, E. McGuinness, N. McInerney, S. Mckay, C. McKee, M. McKenna, N. McKenna, K. McLean, S. Mediratta, Y. Medkova, O. Medzhidov, A. Mehraj, M. Mekhael, O. Mekinde, C. Mellenthin, A. Melucci, K. Mentor, J. Merchant, H. Messias, M. Messeha, C. Meza, P. Mhango, M. Miladinov, M. Milagros Niquen Jimenez, P. Miller, E. Mills, A. Milton, O. A. Minayeva, Z. MinHua Zheng, H. Mischlinger, B. Mo¨ ckli, R. Modi, H. M. Mohamed, M. Mohamed, T. Mohamed Abulghasm, S. A. Mohammad, T. O. Mohammed, A. Mohammed, H. Mohan, M. Mohan, I. Moin, V. Mok, G. Molina, J. Moloney, J. Moneim, M. Monfort Mira, B. Montcusı´ Ventura, M. Montouri, M. Moossdorff, I. Mora-Guzma´ n, B. Moran, R. A. R. Mora´ n, S. Moreno-Ordaz, A´ . Morera, R. Morgan, R. Morley, D. Moro-Valdezate, S. Moros, J. -L. Moss, A. Morven, D. Morton, A. Moynihan, M. Moyo´ n, N. Muduli, N. Mugla, W. Mugla, P. Mu¨ ller, G. Mun, R. Mundhada, I. Munir, F. Munoz, E. Mu ~ noz, A. Mu ~ noz, D. ~ C. Munoz Balderas, E. Murgitroyd, V. Murray, S. Murthy, W. ~ Mushiwokufa, H. Mustafa, B. Mustakimov, P. Mutambanengwe, P. Myint, S. Nadkarni, P. A. Naess, S. Nahar, P. Naidoo, R. Nam, S. Nandhra, N. Nanjappa, V. Narasimhan, W. Nardi, M. Nasir, A. Naughton, D. Naumann, S. Navarro, M. Nawaaz Karimbocus, A. Nazir, S. Ndereya, A. Ndong, I. Negoi, D. Nel, D. Nelson, S. Nepal, T. Nugent, D. Nepogodiev, J. Neufeld, J. Ng, D. Ng, C. E. Ng, S. Ngaserin, L. Ngu, E. Ngwenya, R. N. Fhearaigh, T. -K. Nikolousakis, M. Ninkovic, G. Nita, C. Nitschke, E. Noren, T. Noton, A. Novikova, Z. Nowinka, T. Nyakunengwa, A. Nyalundja, I. Nzenwa, H. Ø Kristensen, C. O’Brien, L. O’Brien, S. O’Brien, J. O’Reilly, S. O’Rourke, M. O’Sullivan, M. O’Dwyer, L. Ochieng, E. Oderoha, K. E. Oh, L. O¨ hlberger, M. O¨ lc¸u¨ m, A. Olkina, M. Omkumar, B. Omnitel, D. 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- Subjects
Adult ,Male ,medicine.medical_specialty ,Biomedical Research ,Coronavirus disease 2019 (COVID-19) ,International Cooperation ,Practice Patterns ,Commission ,Global Health ,Health Services Accessibility ,Perioperative Care ,Education ,Surgeon ,COVID-19 ,surgery ,perioperative care ,Medical ,Pandemic ,Humans ,Medicine ,Practice Patterns, Physicians' ,Graduate ,Pandemics ,Surgeons ,Health Resource ,Infection Control ,Physicians' ,Surgical Procedures ,business.industry ,General surgery ,Middle Aged ,Operative ,Education, Medical, Graduate ,Surgical Procedures, Operative ,Perioperative care ,Health Resources ,Surgery ,Female ,business ,Human - Abstract
Background Coronavirus disease 2019 (COVID-19) was declared a pandemic by the WHO on 11 March 2020 and global surgical practice was compromised. This Commission aimed to document and reflect on the changes seen in the surgical environment during the pandemic, by reviewing colleagues’ experiences and published evidence. Methods In late 2020, BJS contacted colleagues across the global surgical community and asked them to describe how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had affected their practice. In addition to this, the Commission undertook a literature review on the impact of COVID-19 on surgery and perioperative care. A thematic analysis was performed to identify the issues most frequently encountered by the correspondents, as well as the solutions and ideas suggested to address them. Results BJS received communications for this Commission from leading clinicians and academics across a variety of surgical specialties in every inhabited continent. The responses from all over the world provided insights into multiple facets of surgical practice from a governmental level to individual clinical practice and training. Conclusion The COVID-19 pandemic has uncovered a variety of problems in healthcare systems, including negative impacts on surgical practice. Global surgical multidisciplinary teams are working collaboratively to address research questions about the future of surgery in the post-COVID-19 era. The COVID-19 pandemic is severely damaging surgical training. The establishment of a multidisciplinary ethics committee should be encouraged at all surgical oncology centres. Innovative leadership and collaboration is vital in the post-COVID-19 era.
- Published
- 2021
50. Rapid Communication: Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain
- Author
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Giulian, D., Haverkamp, L. J., Li, J., and Karshin, W. L.
- Published
- 1995
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