Search

Your search keyword '"Havekes, Bas"' showing total 404 results
Start Over Author "Havekes, Bas"
404 results on '"Havekes, Bas"'

1. Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes

Author

Parker, Victoria E. R., Robertson, Darren, Erazo-Tapia, Edmundo, Havekes, Bas, Phielix, Esther, de Ligt, Marlies, Roumans, Kay H. M., Mevenkamp, Julian, Sjoberg, Folke, Schrauwen-Hinderling, Vera B., Johansson, Edvin, Chang, Yi-Ting, Esterline, Russell, Smith, Kenneth, Wilkinson, Daniel J., Hansen, Lars, Johansson, Lars, Ambery, Philip, Jermutus, Lutz, and Schrauwen, Patrick

Published
2023
Full Text
View/download PDF

2. Effect of β2-agonist treatment on insulin-stimulated peripheral glucose disposal in healthy men in a randomised placebo-controlled trial

Author

van Beek, Sten M. M., Bruls, Yvonne M. H., Vanweert, Froukje, Fealy, Ciarán E., Connell, Niels J., Schaart, Gert, Moonen-Kornips, Esther, Jörgensen, Johanna A., Vaz, Frédéric M., Smeets, Ellen T. H. C., Joris, Peter J., Gemmink, Anne, Houtkooper, Riekelt H., Hesselink, Matthijs K. C., Bengtsson, Tore, Havekes, Bas, Schrauwen, Patrick, and Hoeks, Joris

Published
2023
Full Text
View/download PDF

3. Effects of the sodium-glucose cotransporter 2 inhibitor dapagliflozin on substrate metabolism in prediabetic insulin resistant individuals: A randomized, double-blind crossover trial

Author

Veelen, Anna, Andriessen, Charlotte, Op den Kamp, Yvo, Erazo-Tapia, Edmundo, de Ligt, Marlies, Mevenkamp, Julian, Jörgensen, Johanna A., Moonen-Kornips, Esther, Schaart, Gert, Esterline, Russell, Havekes, Bas, Oscarsson, Jan, Schrauwen-Hinderling, Vera B., Phielix, Esther, and Schrauwen, Patrick

Published
2023
Full Text
View/download PDF

5. Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism

Author

op den Kamp, Yvo J.M., Gemmink, Anne, de Ligt, Marlies, Dautzenberg, Bas, Kornips, Esther, Jorgensen, Johanna A., Schaart, Gert, Esterline, Russell, Pava, Diego A., Hoeks, Joris, Schrauwen-Hinderling, Vera B., Kersten, Sander, Havekes, Bas, Koves, Timothy R., Muoio, Deborah M., Hesselink, Matthijs K.C., Oscarsson, Jan, Phielix, Esther, and Schrauwen, Patrick

Published
2022
Full Text
View/download PDF

10. Metabolic responses to mild cold acclimation in type 2 diabetes patients

Author

Remie, Carlijn M. E., Moonen, Michiel P. B., Roumans, Kay H. M., Nascimento, Emmani B. M., Gemmink, Anne, Havekes, Bas, Schaart, Gert, Kornips, Esther, Joris, Peter J., Schrauwen-Hinderling, Vera B., Hoeks, Joris, Kersten, Sander, Hesselink, Matthijs K. C., Phielix, Esther, Lichtenbelt, Wouter D. van Marken, and Schrauwen, Patrick

Published
2021
Full Text
View/download PDF

16. Prognostic value of WHO grade in pancreatic neuro-endocrine tumors in Multiple Endocrine Neoplasia type 1: Results from the DutchMEN1 Study Group

Author

Conemans, Elfi B., Brosens, Lodewijk A.A., Raicu-Ionita, Gabriela M., Pieterman, Carolina R.C., de Herder, Wouter W., Dekkers, Olaf M., Hermus, Ad R., van der Horst-Schrivers, Anouk N., Bisschop, Peter H., Havekes, Bas, Drent, Madeleine L., Timmers, H. Th Marc, Offerhaus, G. Johan, Valk, Gerlof D., and Vriens, Menno R.

Published
2017
Full Text
View/download PDF

18. Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance

Author

Roumans, Kay H. M., Lindeboom, Lucas, Veeraiah, Pandichelvam, Remie, Carlijn M. E., Phielix, Esther, Havekes, Bas, Bruls, Yvonne M. H., Brouwers, Martijn C. G. J., Ståhlman, Marcus, Alssema, Marjan, Peters, Harry P. F., de Mutsert, Renée, Staels, Bart, Taskinen, Marja-Riitta, Borén, Jan, Schrauwen, Patrick, and Schrauwen-Hinderling, Vera B.

Published
2020
Full Text
View/download PDF

19. Diagnostic Performance of Magnetic Resonance Imaging for Parathyroid Localization of Primary Hyperparathyroidism: A Systematic Review.

Author

Scheepers, Max H. M. C., Al-Difaie, Zaid, Brandts, Lloyd, Peeters, Andrea, Winkens, Bjorn, Al-Taher, Mahdi, Engelen, Sanne M. E., Lubbers, Tim, Havekes, Bas, Bouvy, Nicole D., and Postma, Alida A.

Subjects
MAGNETIC resonance imaging, PARATHYROID glands, HYPERPARATHYROIDISM
Abstract

Accurate preoperative localization is crucial for successful minimally invasive parathyroidectomy in primary hyperparathyroidism (PHPT). Preoperative localization can be challenging in patients with recurrent and/or multigland disease (MGD). This has led clinicians to investigate multiple imaging techniques, most of which are associated with radiation exposure. Magnetic resonance imaging (MRI) offers ionizing radiation-free and accurate imaging, making it an attractive alternative imaging modality. The objective of this systematic review is to provide an overview of the diagnostic performance of MRI in the localization of PHPT. PubMed and Embase libraries were searched from 1 January 2000 to 31 March 2023. Studies were included that investigated MRI techniques for the localization of PHPT. The exclusion criteria were (1) secondary/tertiary hyperparathyroidism, (2) studies that provided no diagnostic performance values, (3) studies published before 2000, and (4) studies using 0.5 Tesla MRI scanners. Twenty-four articles were included in the systematic review, with a total of 1127 patients with PHPT. In 14 studies investigating conventional MRI for PHPT localization, sensitivities varied between 39.1% and 94.3%. When employing more advanced MRI protocols like 4D MRI for PHPT localization in 11 studies, sensitivities ranged from 55.6% to 100%. The combination of MR imaging with functional techniques such as 18F-FCH-PET/MRI yielded the highest diagnostic accuracy, with sensitivities ranging from 84.2% to 100% in five studies. Despite the limitations of the available evidence, the results of this review indicate that the combination of MR imaging with functional imaging techniques such as 18F-FCH-PET/MRI yielded the highest diagnostic accuracy. Further research on emerging MR imaging modalities, such as 4D MRI and PET/MRI, is warranted, as MRI exposes patients to minimal or no ionizing radiation compared to other imaging modalities. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

20. A prolonged fast improves overnight substrate oxidation without modulating hepatic glycogen in adults with and without nonalcoholic fatty liver: A randomized crossover trial

Author

Roumans, Kay H. M., primary, Veelen, Anna, additional, Andriessen, Charlotte, additional, Mevenkamp, Julian, additional, Kornips, Esther, additional, Veeraiah, Pandichelvam, additional, Havekes, Bas, additional, Peters, Harry P. F., additional, Lindeboom, Lucas, additional, Schrauwen, Patrick, additional, and Schrauwen‐Hinderling, Vera B., additional

Published
2023
Full Text
View/download PDF

21. Replacing Foods with a High-Glycemic Index and High in Saturated Fat by Alternatives with a Low Glycemic Index and Low Saturated Fat Reduces Hepatic Fat, Even in Isocaloric and Macronutrient Matched Conditions

Author

Basset-Sagarminaga, Jeremy, primary, Roumans, Kay H. M., additional, Havekes, Bas, additional, Mensink, Ronald P., additional, Peters, Harry P. F., additional, Zock, Peter L., additional, Mutsert, Renée de, additional, Borén, Jan, additional, Lindeboom, Lucas, additional, Schrauwen, Patrick, additional, and Schrauwen-Hinderling, Vera B., additional

Published
2023
Full Text
View/download PDF

24. Diagnosing pancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1 in daily practice

Author

van Beek, Dirk-Jan, primary, Pieterman, Carolina R. C., additional, Wessels, Frank J., additional, van de Ven, Annenienke C., additional, de Herder, Wouter W., additional, Dekkers, Olaf M., additional, Zandee, Wouter T., additional, Drent, Madeleine L., additional, Bisschop, Peter H., additional, Havekes, Bas, additional, Borel Rinkes, Inne H. M., additional, Vriens, Menno R., additional, and Valk, Gerlof D., additional

Published
2022
Full Text
View/download PDF

25. Progressive diastolic dysfunction in survivors of pediatric differentiated thyroid carcinoma

Author

Reichert, Antoinette D, primary, Nies, Marloes, additional, Tissing, Wim J E, additional, Muller Kobold, Anneke C, additional, Klein Hesselink, Mariëlle S, additional, Brouwers, Adrienne H, additional, Havekes, Bas, additional, van den Heuvel-Eibrink, Marry M, additional, van der Pal, Helena J H, additional, Plukker, John T M, additional, van Santen, Hanneke M, additional, Corssmit, Eleonora P M, additional, Netea-Maier, Romana T, additional, Peeters, Robin P, additional, van Dam, Eveline W C M, additional, Burgerhof, Johannes G M, additional, van der Meer, Peter, additional, Bocca, Gianni, additional, and Links, Thera P, additional

Published
2022
Full Text
View/download PDF

27. Detection of differentiated thyroid carcinoma in exhaled breath with an electronic nose

Author

Scheepers, Max H.M.C., Al-Difaie, Zaid J.J., Wintjens, Anne G.W.E., Engelen, Sanne M.E., Havekes, Bas, Lubbers, Tim, Coolsen, Marielle M.E., Van Der Palen, J., van Ginhoven, Tessa M., Vriens, Menno, Bouvy, N.D., Bouvy, Nicole D., Cognition, Data and Education, Surgery, RS: GROW - R2 - Basic and Translational Cancer Biology, RS: NUTRIM - R2 - Liver and digestive health, MUMC+: MA Heelkunde (9), Interne Geneeskunde, MUMC+: MA Endocrinologie (9), RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, and RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy

Subjects
Pulmonary and Respiratory Medicine, electronic nose, BETHESDA SYSTEM, exhaled air, thyroid carcinoma, innovative diagnostics, LUNG-CANCER, Breath Tests, SDG 3 - Good Health and Well-being, SMOKING STATUS, Exhalation, volatile organic compounds, Humans, Thyroid Neoplasms
Abstract

This proof-of-principle study investigates the diagnostic performance of the Aeonose in differentiating malignant from benign thyroid diseases based on volatile organic compound analysis in exhaled breath. All patients with a suspicious thyroid nodule planned for surgery, exhaled in the Aeonose. Definitive diagnosis was provided by histopathological determination after surgical resection. Breath samples were analyzed utilizing artificial neural networking. About 133 participants were included, 48 of whom were diagnosed with well-differentiated thyroid cancer. A sensitivity of 0.73 and a negative predictive value (NPV) of 0.82 were found. The sensitivity and NPV improved to 0.94 and 0.95 respectively after adding clinical variables via multivariate logistic regression analysis. This study demonstrates the feasibility of the Aeonose to discriminate between malignant and benign thyroid disease. With a high NPV, low cost, and non-invasive nature, the Aeonose may be a promising diagnostic tool in the detection of thyroid cancer.

Published
2022

28. Diagnosing pancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1 in daily practice

Author

Pieterman, Carolina, primary, Van, Beek Dirk-Jan, additional, Wessels, Frank J, additional, van, de Ven Annenienke C, additional, de, Herder Wouter W, additional, Dekkers, Olaf M, additional, Zandee, Wouter T, additional, Drent, Madeline L, additional, Bisschop, Peter H, additional, Havekes, Bas, additional, Borel, Rinkes Inne HM, additional, Vriens, Menno R, additional, and Valk, Gerlof D, additional

Published
2022
Full Text
View/download PDF

29. Detection of differentiated thyroid carcinoma in exhaled breath with an electronic nose

Author

Scheepers, Max H. M. C., Al-Difaie, Zaid J. J., Wintjens, Anne G. W. E., Engelen, Sanne M. E., Havekes, Bas, Lubbers, Tim, Coolsen, Marielle M. E., van der Palen, Job, van Ginhoven, Tessa M., Vriens, Menno, Bouvy, Nicole D., Scheepers, Max H. M. C., Al-Difaie, Zaid J. J., Wintjens, Anne G. W. E., Engelen, Sanne M. E., Havekes, Bas, Lubbers, Tim, Coolsen, Marielle M. E., van der Palen, Job, van Ginhoven, Tessa M., Vriens, Menno, and Bouvy, Nicole D.

Abstract

This proof-of-principle study investigates the diagnostic performance of the Aeonose in differentiating malignant from benign thyroid diseases based on volatile organic compound analysis in exhaled breath. All patients with a suspicious thyroid nodule planned for surgery, exhaled in the Aeonose. Definitive diagnosis was provided by histopathological determination after surgical resection. Breath samples were analyzed utilizing artificial neural networking. About 133 participants were included, 48 of whom were diagnosed with well-differentiated thyroid cancer. A sensitivity of 0.73 and a negative predictive value (NPV) of 0.82 were found. The sensitivity and NPV improved to 0.94 and 0.95 respectively after adding clinical variables via multivariate logistic regression analysis. This study demonstrates the feasibility of the Aeonose to discriminate between malignant and benign thyroid disease. With a high NPV, low cost, and non-invasive nature, the Aeonose may be a promising diagnostic tool in the detection of thyroid cancer.

Published
2022

30. Diagnosing pancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1 in daily practice

Author

van Beek, Dirk Jan, Wessels, Frank J., Pieterman, Carolina R.C., van de Ven, Annenienke C., de Herder, Wouter W., Dekkers, Olaf M., Zandee, Wouter T., Drent, Madeleine L., Bisschop, Peter H., Havekes, Bas, Borel Rinkes, Inne H.M., Vriens, Menno R., Valk, Gerlof D., van Beek, Dirk Jan, Wessels, Frank J., Pieterman, Carolina R.C., van de Ven, Annenienke C., de Herder, Wouter W., Dekkers, Olaf M., Zandee, Wouter T., Drent, Madeleine L., Bisschop, Peter H., Havekes, Bas, Borel Rinkes, Inne H.M., Vriens, Menno R., and Valk, Gerlof D.

Abstract

Background: In multiple endocrine neoplasia type 1 (MEN1), pancreatic neuroendocrine tumors (PanNETs) have a high prevalence and represent the main cause of death. This study aimed to assess the diagnostic accuracy of the currently used conventional pancreatic imaging techniques and the added value of fine needle aspirations (FNAs). Methods: Patients who had at least one imaging study were included from the population-based MEN1 database of the DutchMEN Study Group from 1990 to 2017. Magnetic resonance imaging (MRI), computed tomography (CT), endoscopic ultrasonography (EUS), FNA, and surgical resection specimens were obtained. The first MRI, CT, or EUS was considered as the index test. For a comparison of the diagnostic accuracy of MRI versus CT, patients with their index test taken between 2010 and 2017 were included. The reference standard consisted of surgical histopathology or radiological follow-up. Results: A total of 413 patients (92.8% of the database) underwent 3,477 imaging studies. The number of imaging studies per patient increased, and a preference for MRI was observed in the last decade. Overall diagnostic accuracy was good with a positive (PPV) and negative predictive value (NPV) of 88.9% (95% confidence interval, 76.0–95.6) and 92.8% (89.4–95.1), respectively, for PanNET in the pancreatic head and 92.0% (85.3–96.0) and 85.3% (80.5–89.1), respectively, in the body/tail. For MRI, PPV and NPV for pancreatic head tumors were 100% (76.1–100) and 87.1% (76.3–93.6) and for CT, 60.0% (22.9–88.4) and 70.4% (51.3–84.3), respectively. For body/tail tumors, PPV and NPV were 91.3% (72.0–98.8) and 87.0% (75.3–93.9), respectively, for MRI and 100% (74.9–100) and 77.8% (54.3–91.5), respectively, for CT. Pathology confirmed a PanNET in 106 out of 110 (96.4%) resection specimens. FNA was performed on 34 lesions in 33 patients and was considered PanNET in 24 [all confirmed PanNET by histology (10) or follow-up (14)], normal/cyst/unrepresentative in 6 (all confirmed

Published
2022

31. Detection of differentiated thyroid carcinoma in exhaled breath with an electronic nose

Author

Heelkunde Opleiding, MS CGO, Cancer, Scheepers, Max H M C, Al-Difaie, Zaid J J, Wintjens, Anne G W E, Engelen, Sanne M E, Havekes, Bas, Lubbers, Tim, Coolsen, Marielle M E, van der Palen, Job, van Ginhoven, Tessa M, Vriens, Menno, Bouvy, Nicole D, Heelkunde Opleiding, MS CGO, Cancer, Scheepers, Max H M C, Al-Difaie, Zaid J J, Wintjens, Anne G W E, Engelen, Sanne M E, Havekes, Bas, Lubbers, Tim, Coolsen, Marielle M E, van der Palen, Job, van Ginhoven, Tessa M, Vriens, Menno, and Bouvy, Nicole D

Published
2022

32. Diagnosing pancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1 in daily practice

Author

Heelkunde Opleiding, Cancer, MS CGO, MS Endocriene Oncologie, MS Radiologie, Regenerative Medicine and Stem Cells, van Beek, Dirk-Jan, Pieterman, Carolina R C, Wessels, Frank J, van de Ven, Annenienke C, de Herder, Wouter W, Dekkers, Olaf M, Zandee, Wouter T, Drent, Madeleine L, Bisschop, Peter H, Havekes, Bas, Borel Rinkes, Inne H M, Vriens, Menno R, Valk, Gerlof D, Heelkunde Opleiding, Cancer, MS CGO, MS Endocriene Oncologie, MS Radiologie, Regenerative Medicine and Stem Cells, van Beek, Dirk-Jan, Pieterman, Carolina R C, Wessels, Frank J, van de Ven, Annenienke C, de Herder, Wouter W, Dekkers, Olaf M, Zandee, Wouter T, Drent, Madeleine L, Bisschop, Peter H, Havekes, Bas, Borel Rinkes, Inne H M, Vriens, Menno R, and Valk, Gerlof D

Published
2022

33. Progressive diastolic dysfunction in survivors of pediatric differentiated thyroid carcinoma

Author

PMC Medisch specialisten, Speerpunt, Zorg en O&O, Cancer, Child Health, Endocrinologie patientenzorg, Brain, Reichert, Antoinette D., Nies, Marloes, Tissing, Wim J.E., Muller Kobold, Anneke C., Klein Hesselink, Mariëlle S., Brouwers, Adrienne H., Havekes, Bas, van den Heuvel-Eibrink, Marry M., van der Pal, Helena J.H., Plukker, John T.M., van Santen, Hanneke M., Corssmit, Eleonora P.M., Netea-Maier, Romana T., Peeters, Robin P., van Dam, Eveline W.C.M., Burgerhof, Johannes G.M., van der Meer, Peter, Bocca, Gianni, Links, Thera P., PMC Medisch specialisten, Speerpunt, Zorg en O&O, Cancer, Child Health, Endocrinologie patientenzorg, Brain, Reichert, Antoinette D., Nies, Marloes, Tissing, Wim J.E., Muller Kobold, Anneke C., Klein Hesselink, Mariëlle S., Brouwers, Adrienne H., Havekes, Bas, van den Heuvel-Eibrink, Marry M., van der Pal, Helena J.H., Plukker, John T.M., van Santen, Hanneke M., Corssmit, Eleonora P.M., Netea-Maier, Romana T., Peeters, Robin P., van Dam, Eveline W.C.M., Burgerhof, Johannes G.M., van der Meer, Peter, Bocca, Gianni, and Links, Thera P.

Published
2022

34. Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

Author

Hanssen, Mark J.W., Hoeks, Joris, Brans, Boudewijn, van der Lans, Anouk A.J.J., Schaart, Gert, van den Driessche, Jose J., Jorgensen, Johanna A., Boekschoten, Mark V., Hesselink, Matthijs K.C., Havekes, Bas, Kersten, Sander, Mottaghy, Felix M., van Marken Lichtenbelt, Wouter D., and Schrauwen, Patrick

Subjects
Acclimatization -- Health aspects, Insulin -- Dosage and administration, Type 2 diabetes -- Care and treatment, Muscles -- Research, Biological sciences, Health
Abstract

Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15°C) increased peripheral insulin sensitivity by ~43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake., Cold-induced adaptive thermogenesis has gained considerable interest due to the 'rediscovery' of BAT in adult humans in 2009 (refs. 1-3). In response to these findings, activation of human BAT has [...]

Published
2015
Full Text
View/download PDF

35. Erratum. Effects of the SGLT2 Inhibitor Dapagliflozin on Energy Metabolism in Patients With Type 2 Diabetes: A Randomized, Double-Blind Crossover Trial. Diabetes Care 2021;44:1334–1343

Author

Kamp, Yvo J.M. Op den, primary, Ligt, Marlies de, additional, Dautzenberg, Bas, additional, Kornips, Esther, additional, Esterline, Russell, additional, Hesselink, Matthijs K.C., additional, Hoeks, Joris, additional, Schrauwen-Hinderling, Vera B., additional, Havekes, Bas, additional, Oscarsson, Jan, additional, Phielix, Esther, additional, and Schrauwen, Patrick, additional

Published
2022
Full Text
View/download PDF

36. Well-Differentiated Bronchopulmonary Neuroendocrine Tumors: More Than One Entity

Author

van den Broek, Medard F.M., primary, Levy, Sonja, additional, Buikhuisen, Wieneke A., additional, Dijke, Kim, additional, Hartemink, Koen J., additional, van Leeuwaarde, Rachel S., additional, Vriens, Menno R., additional, Tesselaar, Margot E.T., additional, Valk, Gerlof D., additional, de Herder, Wouter, additional, Dekkers, Olaf, additional, van de Ven, Annenienke, additional, Havekes, Bas, additional, Drent, Madeleine, additional, Bisschop, Peter, additional, Zandee, Wouter, additional, and Valk, Gerlof, additional

Published
2021
Full Text
View/download PDF

37. Bone Mineral Density in Adult Survivors of Pediatric Differentiated Thyroid Carcinoma: A Longitudinal Follow-Up Study

Author

Dekker, Bernadette L., primary, Muller Kobold, Anneke C., additional, Brouwers, Adrienne H., additional, Williams, Graham R., additional, Nies, Marloes, additional, Klein Hesselink, Mariëlle S., additional, van der Horst-Schrivers, Anouk N.A., additional, Havekes, Bas, additional, van den Heuvel-Eibrink, Marry M., additional, van der Pal, Heleen J.H., additional, Plukker, John Th. M., additional, Ronckers, Cecile M., additional, van Santen, Hanneke M., additional, Burgerhof, Johannes G.M., additional, Corssmit, Eleonora P.M., additional, Netea-Maier, Romana T., additional, Peeters, Robin P., additional, van Dam, Eveline W.C.M., additional, Boot, Annemieke M., additional, Tissing, Wim J.E., additional, Bocca, Gianni, additional, and Links, Thera P., additional

Published
2021
Full Text
View/download PDF

38. Pediatric Differentiated Thyroid Carcinoma in The Netherlands: A Nationwide Follow-Up Study

Author

Klein Hesselink, Mariëlle S., Nies, Marloes, Bocca, Gianni, Brouwers, Adrienne H., Burgerhof, Johannes G. M., van Dam, Eveline W. C. M., Havekes, Bas, van den Heuvel-Eibrink, Marry M., Corssmit, Eleonora P. M., Kremer, Leontien C. M., Netea-Maier, Romana T., van der Pal, Heleen J. H., Peeters, Robin P., Schmid, Kurt W., Smit, Johannes W. A., Williams, Graham R., Plukker, John T. M., Ronckers, Cécile M., van Santen, Hanneke M., Tissing, Wim J. E., and Links, Thera P.

Published
2016

41. Supplement to: Breast-cancer predisposition in multiple endocrine neoplasia type 1.

Author

Conemans, Elfi B., Cornelissen, Chantal, van Blokland, Marja T., Mannstadt, Michael, Pieterman, Carla R.C., Binquet, Christine, Dekkers, Olaf M., Drent, Madeleine L., van der Horst-Schrivers, Anouk N.A., de Herder, Wouter W., Havekes, Bas, Fliers, Eric, Hermus, Ad R., Vriens, Menno R., Marc Timmers, Th. H., van der Wall, Elsken, Brown, Myles, van der Luijt, Rob B., and van Diest, Paul J.

Published
2014

42. Initiating Pancreatic Neuroendocrine Tumor (pNET) Screening in Young MEN1 Patients: Results From the DutchMEN Study Group

Author

Klein Haneveld, Mirthe J, primary, van Treijen, Mark J C, additional, Pieterman, Carolina R C, additional, Dekkers, Olaf M, additional, van de Ven, Annenienke, additional, de Herder, Wouter W, additional, Zandee, Wouter T, additional, Drent, Madeleine L, additional, Bisschop, Peter H, additional, Havekes, Bas, additional, Vriens, Menno R, additional, Verrijn Stuart, Annemarie A, additional, Valk, Gerlof D, additional, and van Leeuwaarde, Rachel S, additional

Published
2021
Full Text
View/download PDF

45. Evidence for a Direct Effect of the NAD+ Precursor Acipimox on Muscle Mitochondrial Function in Humans

Author

van de Weijer, Tineke, Phielix, Esther, Bilet, Lena, Williams, Evan G., Ropelle, Eduardo R., Bierwagen, Alessandra, Livingstone, Roshan, Nowotny, Peter, Sparks, Lauren M., Paglialunga, Sabina, Szendroedi, Julia, Havekes, Bas, Moullan, Norman, Pirinen, Eija, Hwang, Jong-Hee, Schrauwen-Hinderling, Vera B., Hesselink, Matthijs K.C., Auwerx, Johan, Roden, Michael, and Schrauwen, Patrick

Published
2015
Full Text
View/download PDF

47. Progressive Diastolic Dysfunction in Survivors of Pediatric DTC - Supplemental Data

Author

Reichert, Antoinette, Nies, Marloes, Tissing, Wim J.E., C. Muller Kobold, Anneke, Klein Hesselink, Marielle S., Brouwers, Adrienne H., Havekes, Bas, M. van den Heuvel-Eibrink, Marry, van der Pal, Helena J. H., Plukker, John T. M., van Santen, Hanneke M., Corssmit, Eleonora, T. Netea-Maier, Romana, P. Peeters, Robin, W.C.M. van Dam, Eveline, Burgerhof, Johannes G.M., van der Meer, Peter, Bocca, Gianni, and Links, Thera P.

Subjects
population characteristics, social sciences, human activities, humanities
Abstract

Supplemental Data to Progressive Diastolic Dysfunction in Survivors of Pediatric DTC

Published
2021
Full Text
View/download PDF

48. Initiating Pancreatic Neuroendocrine Tumor (pNET) Screening in Young MEN1 Patients:Results from the DutchMEN Study Group

Author

Klein Haneveld, Mirthe J., Van Treijen, Mark J.C., Pieterman, Carolina R.C., Dekkers, Olaf M., Van De Ven, Annenienke, De Herder, Wouter W., Zandee, Wouter T., Drent, Madeleine L., Bisschop, Peter H., Havekes, Bas, Vriens, Menno R., Verrijn Stuart, Annemarie A., Valk, Gerlof D., Van Leeuwaarde, Rachel S., Klein Haneveld, Mirthe J., Van Treijen, Mark J.C., Pieterman, Carolina R.C., Dekkers, Olaf M., Van De Ven, Annenienke, De Herder, Wouter W., Zandee, Wouter T., Drent, Madeleine L., Bisschop, Peter H., Havekes, Bas, Vriens, Menno R., Verrijn Stuart, Annemarie A., Valk, Gerlof D., and Van Leeuwaarde, Rachel S.

Abstract

Context: Nonfunctioning pancreatic neuroendocrine tumors (NF-pNETs) are highly prevalent and constitute an important cause of mortality in patients with multiple endocrine neoplasia type 1 (MEN1). Still, the optimal age to initiate screening for pNETs is under debate. Objective: The aim of this work is to assess the age of occurrence of clinically relevant NF-pNETs in young MEN1 patients. Methods: Pancreatic imaging data of MEN1 patients were retrieved from the DutchMEN Study Group database. Interval-censored survival methods were used to describe age-related penetrance, compare survival curves, and develop a parametric model for estimating the risk of having clinically relevant NF-pNET at various ages. The primary objective was to assess age at occurrence of clinically relevant NF-pNET (size ≥†20 mm or rapid growth); secondary objectives were the age at occurrence of NF-pNET of any size and pNET-associated metastasized disease. Results: Five of 350 patients developed clinically relevant NF-pNETs before age 18 years, 2 of whom subsequently developed lymph node metastases. No differences in clinically relevant NF-pNET-free survival were found for sex, time frame, and type of MEN1 diagnosis or genotype. The estimated ages (median, 95% CI) at a 1%, 2.5%, and 5% risk of having developed a clinically relevant tumor are 9.5 (6.5-12.7), 13.5 (10.2-16.9), and 17.8 years (14.3-21.4), respectively. Conclusion: Analyses from this population-based cohort indicate that start of surveillance for NF-pNETs with pancreatic imaging at age 13 to 14 years is justified. The psychological and medical burden of screening at a young age should be considered.

Published
2021

49. Metabolic responses to mild cold acclimation in type 2 diabetes patients

Author

Remie, Carlijn M.E., Moonen, Michiel P.B., Roumans, Kay H.M., Nascimento, Emmani B.M., Gemmink, Anne, Havekes, Bas, Schaart, Gert, Kornips, Esther, Joris, Peter J., Schrauwen-Hinderling, Vera B., Hoeks, Joris, Kersten, Sander, Hesselink, Matthijs K.C., Phielix, Esther, van Marken Lichtenbelt, Wouter D., Schrauwen, Patrick, Remie, Carlijn M.E., Moonen, Michiel P.B., Roumans, Kay H.M., Nascimento, Emmani B.M., Gemmink, Anne, Havekes, Bas, Schaart, Gert, Kornips, Esther, Joris, Peter J., Schrauwen-Hinderling, Vera B., Hoeks, Joris, Kersten, Sander, Hesselink, Matthijs K.C., Phielix, Esther, van Marken Lichtenbelt, Wouter D., and Schrauwen, Patrick

Abstract

Mild cold acclimation for 10 days has been previously shown to markedly improve insulin sensitivity in patients with type 2 diabetes. Here we show in a single-arm intervention study (Trialregister.nl ID: NL4469/NTR5711) in nine patients with type 2 diabetes that ten days of mild cold acclimation (16–17 °C) in which observable, overt shivering was prevented, does not result in improved insulin sensitivity, postprandial glucose and lipid metabolism or intrahepatic lipid content and only results in mild effects on overnight fasted fat oxidation, postprandial energy expenditure and aortic augmentation index. The lack of marked metabolic effects in this study is associated with a lack of self-reported shivering and a lack of upregulation of gene expression of muscle activation or muscle contraction pathways in skeletal muscle and suggests that some form of muscle contraction is needed for beneficial effects of mild cold acclimation.

Published
2021

50. Bone Mineral Density in Adult Survivors of Pediatric Differentiated Thyroid Carcinoma: a longitudinal follow-up study

Author

Speerpunt, Zorg en O&O, Child Health, PMC Medisch specialisten, Endocrinologie patientenzorg, Brain, Cancer, Dekker, Bernadette L, Muller Kobold, Anneke C, Brouwers, Adrienne H, Williams, Graham R R, Nies, Marloes, Klein Hesselink, Mariëlle Sanne, van der Horst-Schrivers, Anouk N A, Havekes, Bas, van den Heuvel-Eibrink, Marry M, van der Pal, Heleen J H, Plukker, John Th M, Ronckers, Cecile M, van Santen, Hanneke M, Burgerhof, Johannes G M, Corssmit, Eleonora P M, Netea-Maier, Romana, Peeters, Robin P, van Dam, Eveline W C M, Boot, Annemieke, Tissing, Wim J E, Bocca, Gianni, Links, Thera P, Speerpunt, Zorg en O&O, Child Health, PMC Medisch specialisten, Endocrinologie patientenzorg, Brain, Cancer, Dekker, Bernadette L, Muller Kobold, Anneke C, Brouwers, Adrienne H, Williams, Graham R R, Nies, Marloes, Klein Hesselink, Mariëlle Sanne, van der Horst-Schrivers, Anouk N A, Havekes, Bas, van den Heuvel-Eibrink, Marry M, van der Pal, Heleen J H, Plukker, John Th M, Ronckers, Cecile M, van Santen, Hanneke M, Burgerhof, Johannes G M, Corssmit, Eleonora P M, Netea-Maier, Romana, Peeters, Robin P, van Dam, Eveline W C M, Boot, Annemieke, Tissing, Wim J E, Bocca, Gianni, and Links, Thera P

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results