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293 results on '"Hauser, Blake M"'

3. Rebound HIV-1 in cerebrospinal fluid after antiviral therapy interruption is mainly clonally amplified R5 T cell-tropic virus

Author

Kincer, Laura P, Joseph, Sarah Beth, Gilleece, Maria M, Hauser, Blake M, Sizemore, Sabrina, Zhou, Shuntai, Di Germanio, Clara, Zetterberg, Henrik, Fuchs, Dietmar, Deeks, Steven G, Spudich, Serena, Gisslen, Magnus, Price, Richard W, and Swanstrom, Ronald

Subjects
Microbiology, Biological Sciences, Neurosciences, Infectious Diseases, HIV/AIDS, Pediatric AIDS, Pediatric, 2.2 Factors relating to the physical environment, Aetiology, Infection, Good Health and Well Being, Humans, T-Lymphocytes, HIV-1, HIV Infections, Central Nervous System, Antiviral Agents, Medical Microbiology
Abstract

HIV-1 persists as a latent reservoir in people receiving suppressive antiretroviral therapy (ART). When ART is interrupted (treatment interruption/TI), rebound virus re-initiates systemic infection in the lymphoid system. During TI, HIV-1 is also detected in cerebrospinal fluid (CSF), although the source of this rebound virus is unknown. To investigate whether there is a distinct HIV-1 reservoir in the central nervous system (CNS), we compared rebound virus after TI in the blood and CSF of 11 participants. Peak rebound CSF viral loads vary and we show that high viral loads and the appearance of clonally amplified viral lineages in the CSF are correlated with the transient influx of white blood cells. We found no evidence of rebound macrophage-tropic virus in the CSF, even in one individual who had macrophage-tropic HIV-1 in the CSF pre-therapy. We propose a model in which R5 T cell-tropic virus is released from infected T cells that enter the CNS from the blood (or are resident in the CNS during therapy), with clonal amplification of infected T cells and virus replication occurring in the CNS during TI.

Published
2023

4. A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in mice

Author

Case, James Brett, Sanapala, Shilpa, Dillen, Carly, Rhodes, Victoria, Zmasek, Christian, Chicz, Taras M., Switzer, Charlotte E., Scheaffer, Suzanne M., Georgiev, George, Jacob-Dolan, Catherine, Hauser, Blake M., Dos Anjos, Déborah Carolina Carvalho, Adams, Lucas J., Soudani, Nadia, Liang, Chieh-Yu, Ying, Baoling, McNamara, Ryan P., Scheuermann, Richard H., Boon, Adrianus C.M., Fremont, Daved H., Whelan, Sean P.J., Schmidt, Aaron G., Sette, Alessandro, Grifoni, Alba, Frieman, Matthew B., and Diamond, Michael S.

Published
2024
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5. Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice

Author

Nanishi, Etsuro, Borriello, Francesco, Seo, Hyuk-Soo, O’Meara, Timothy R., McGrath, Marisa E., Saito, Yoshine, Chen, Jing, Diray-Arce, Joann, Song, Kijun, Xu, Andrew Z., Barman, Soumik, Menon, Manisha, Dong, Danica, Caradonna, Timothy M., Feldman, Jared, Hauser, Blake M., Schmidt, Aaron G., Baden, Lindsey R., Ernst, Robert K., Dillen, Carly, Yu, Jingyou, Chang, Aiquan, Hilgers, Luuk, Platenburg, Peter Paul, Dhe-Paganon, Sirano, Barouch, Dan H., Ozonoff, Al, Zanoni, Ivan, Frieman, Matthew B., Dowling, David J., and Levy, Ofer

Published
2023
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6. Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice

Author

Nanishi, Etsuro, Borriello, Francesco, Seo, Hyuk-Soo, O’Meara, Timothy R., McGrath, Marisa E., Saito, Yoshine, Chen, Jing, Diray-Arce, Joann, Song, Kijun, Xu, Andrew Z., Barman, Soumik, Menon, Manisha, Dong, Danica, Caradonna, Timothy M., Feldman, Jared, Hauser, Blake M., Schmidt, Aaron G., Baden, Lindsey R., Ernst, Robert K., Dillen, Carly, Yu, Jingyou, Chang, Aiquan, Hilgers, Luuk, Platenburg, Peter Paul, Dhe-Paganon, Sirano, Barouch, Dan H., Ozonoff, Al, Zanoni, Ivan, Frieman, Matthew B., Dowling, David J., and Levy, Ofer

Published
2023
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7. Rapid generation of potent antibodies by autonomous hypermutation in yeast

Author

Wellner, Alon, McMahon, Conor, Gilman, Morgan SA, Clements, Jonathan R, Clark, Sarah, Nguyen, Kianna M, Ho, Ming H, Hu, Vincent J, Shin, Jung-Eun, Feldman, Jared, Hauser, Blake M, Caradonna, Timothy M, Wingler, Laura M, Schmidt, Aaron G, Marks, Debora S, Abraham, Jonathan, Kruse, Andrew C, and Liu, Chang C

Subjects
Prevention, Biotechnology, Vaccine Related, Immunization, Generic health relevance, Antibodies, Antibody Formation, Antigens, COVID-19, Humans, Peptide Library, Protein Engineering, Recombinant Proteins, SARS-CoV-2, Saccharomyces cerevisiae, Single-Domain Antibodies, Spike Glycoprotein, Coronavirus, Medicinal and Biomolecular Chemistry, Biochemistry and Cell Biology, Biochemistry & Molecular Biology
Abstract

The predominant approach for antibody generation remains animal immunization, which can yield exceptionally selective and potent antibody clones owing to the powerful evolutionary process of somatic hypermutation. However, animal immunization is inherently slow, not always accessible and poorly compatible with many antigens. Here, we describe 'autonomous hypermutation yeast surface display' (AHEAD), a synthetic recombinant antibody generation technology that imitates somatic hypermutation inside engineered yeast. By encoding antibody fragments on an error-prone orthogonal DNA replication system, surface-displayed antibody repertoires continuously mutate through simple cycles of yeast culturing and enrichment for antigen binding to produce high-affinity clones in as little as two weeks. We applied AHEAD to generate potent nanobodies against the SARS-CoV-2 S glycoprotein, a G-protein-coupled receptor and other targets, offering a template for streamlined antibody generation at large.

Published
2021

9. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

Author

Clausen, Thomas Mandel, Sandoval, Daniel R, Spliid, Charlotte B, Pihl, Jessica, Perrett, Hailee R, Painter, Chelsea D, Narayanan, Anoop, Majowicz, Sydney A, Kwong, Elizabeth M, McVicar, Rachael N, Thacker, Bryan E, Glass, Charles A, Yang, Zhang, Torres, Jonathan L, Golden, Gregory J, Bartels, Phillip L, Porell, Ryan N, Garretson, Aaron F, Laubach, Logan, Feldman, Jared, Yin, Xin, Pu, Yuan, Hauser, Blake M, Caradonna, Timothy M, Kellman, Benjamin P, Martino, Cameron, Gordts, Philip LSM, Chanda, Sumit K, Schmidt, Aaron G, Godula, Kamil, Leibel, Sandra L, Jose, Joyce, Corbett, Kevin D, Ward, Andrew B, Carlin, Aaron F, and Esko, Jeffrey D

Subjects
Biochemistry and Cell Biology, Biological Sciences, Infectious Diseases, Coronaviruses, Coronaviruses Therapeutics and Interventions, Emerging Infectious Diseases, Infection, Amino Acid Sequence, Angiotensin-Converting Enzyme 2, Betacoronavirus, Binding Sites, COVID-19, Cell Line, Coronavirus Infections, Heparin, Heparitin Sulfate, Humans, Kidney, Lung, Molecular Dynamics Simulation, Pandemics, Peptidyl-Dipeptidase A, Pneumonia, Viral, Protein Binding, Protein Domains, Recombinant Proteins, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Virus Internalization, coronavirus, heparan sulfate, heparan sulfate-binding proteins, heparin, lung epithelial cells, pseudotyped virus, spike proteins, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD). Docking studies suggest a heparin/heparan sulfate-binding site adjacent to the ACE2-binding site. Both ACE2 and heparin can bind independently to spike protein in vitro, and a ternary complex can be generated using heparin as a scaffold. Electron micrographs of spike protein suggests that heparin enhances the open conformation of the RBD that binds ACE2. On cells, spike protein binding depends on both heparan sulfate and ACE2. Unfractionated heparin, non-anticoagulant heparin, heparin lyases, and lung heparan sulfate potently block spike protein binding and/or infection by pseudotyped virus and authentic SARS-CoV-2 virus. We suggest a model in which viral attachment and infection involves heparan sulfate-dependent enhancement of binding to ACE2. Manipulation of heparan sulfate or inhibition of viral adhesion by exogenous heparin presents new therapeutic opportunities.

Published
2020

13. A novel homozygous nonsense variant in CABP4 causing stationary cone/rod synaptic dysfunction.

Author

Hauser, Blake M., Place, Emily, Huckfeldt, Rachel, and Vavvas, Demetrios G.

Subjects
*COLOR vision, *CONGENITAL disorders, *VISUAL acuity, *SYMPTOMS, *CARRIER proteins
Abstract

Introduction: Variants in the CABP4 gene cause a phenotype to be included in the spectrum of congenital stationary night blindness, though some reports suggest that the clinical abnormalities are more accurately categorized as a synaptic disease of the cones and rods. We report a novel homozygous nonsense variant in CABP4 in a patient complaining of non-progressive reduced visual acuity and photophobia but not nyctalopia. Methods: Complete ocular examination, fundus photographs, autofluorescence, optical coherence tomography, electroretinography, and targeted sequencing of known inherited retinal disease-associated genes. Results: A 25-year-old man monitored for 13 years complains of a lifelong history of stable reduced visual acuity (20/150), impaired color vision (1 of 14 plates), small-amplitude nystagmus, and photophobia without nyctalopia. He is also hyperopic (+7D), and his electroretinography shows significantly reduced rod and cone responses. Targeted genetic analysis revealed a novel homozygous variant in the CABP4 gene at c.181C>T, p. (Gln61*) underlying his clinical presentation. Conclusions: A novel variant in CABP4 is associated with stationary cone and rod dysfunction resulting in decreased acuity, color deficit, and photophobia, but not nyctalopia. [ABSTRACT FROM AUTHOR]

Published
2024
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16. mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant

Author

Garcia-Beltran, Wilfredo F., St. Denis, Kerri J., Hoelzemer, Angelique, Lam, Evan C., Nitido, Adam D., Sheehan, Maegan L., Berrios, Cristhian, Ofoman, Onosereme, Chang, Christina C., Hauser, Blake M., Feldman, Jared, Roederer, Alex L., Gregory, David J., Poznansky, Mark C., Schmidt, Aaron G., Iafrate, A. John, Naranbhai, Vivek, and Balazs, Alejandro B.

Published
2022
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18. Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike

Author

Tong, Pei, Gautam, Avneesh, Windsor, Ian W., Travers, Meghan, Chen, Yuezhou, Garcia, Nicholas, Whiteman, Noah B., McKay, Lindsay G.A., Storm, Nadia, Malsick, Lauren E., Honko, Anna N., Lelis, Felipe J.N., Habibi, Shaghayegh, Jenni, Simon, Cai, Yongfei, Rennick, Linda J., Duprex, W. Paul, McCarthy, Kevin R., Lavine, Christy L., Zuo, Teng, Lin, Junrui, Zuiani, Adam, Feldman, Jared, MacDonald, Elizabeth A., Hauser, Blake M., Griffths, Anthony, Seaman, Michael S., Schmidt, Aaron G., Chen, Bing, Neuberg, Donna, Bajic, Goran, Harrison, Stephen C., and Wesemann, Duane R.

Published
2021
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19. An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates

Author

Zabaleta, Nerea, Dai, Wenlong, Bhatt, Urja, Hérate, Cécile, Maisonnasse, Pauline, Chichester, Jessica A., Sanmiguel, Julio, Estelien, Reynette, Michalson, Kristofer T., Diop, Cheikh, Maciorowski, Dawid, Dereuddre-Bosquet, Nathalie, Cavarelli, Mariangela, Gallouët, Anne-Sophie, Naninck, Thibaut, Kahlaoui, Nidhal, Lemaitre, Julien, Qi, Wenbin, Hudspeth, Elissa, Cucalon, Allison, Dyer, Cecilia D., Pampena, M. Betina, Knox, James J., LaRocque, Regina C., Charles, Richelle C., Li, Dan, Kim, Maya, Sheridan, Abigail, Storm, Nadia, Johnson, Rebecca I., Feldman, Jared, Hauser, Blake M., Contreras, Vanessa, Marlin, Romain, Tsong Fang, Raphaël Ho, Chapon, Catherine, van der Werf, Sylvie, Zinn, Eric, Ryan, Aisling, Kobayashi, Dione T., Chauhan, Ruchi, McGlynn, Marion, Ryan, Edward T., Schmidt, Aaron G., Price, Brian, Honko, Anna, Griffiths, Anthony, Yaghmour, Sam, Hodge, Robert, Betts, Michael R., Freeman, Mason W., Wilson, James M., Le Grand, Roger, and Vandenberghe, Luk H.

Published
2021
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20. In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies

Author

Li, Dapeng, Edwards, Robert J., Manne, Kartik, Martinez, David R., Schäfer, Alexandra, Alam, S. Munir, Wiehe, Kevin, Lu, Xiaozhi, Parks, Robert, Sutherland, Laura L., Oguin, Thomas H., III, McDanal, Charlene, Perez, Lautaro G., Mansouri, Katayoun, Gobeil, Sophie M.C., Janowska, Katarzyna, Stalls, Victoria, Kopp, Megan, Cai, Fangping, Lee, Esther, Foulger, Andrew, Hernandez, Giovanna E., Sanzone, Aja, Tilahun, Kedamawit, Jiang, Chuancang, Tse, Longping V., Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Cronin, Kenneth, Gee-Lai, Victoria, Deyton, Margaret, Barr, Maggie, Von Holle, Tarra, Macintyre, Andrew N., Stover, Erica, Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Scobey, Trevor D., Rountree, Wes, Wang, Yunfei, Moody, M. Anthony, Cain, Derek W., DeMarco, C. Todd, Denny, Thomas N., Woods, Christopher W., Petzold, Elizabeth W., Schmidt, Aaron G., Teng, I-Ting, Zhou, Tongqing, Kwong, Peter D., Mascola, John R., Graham, Barney S., Moore, Ian N., Seder, Robert, Andersen, Hanne, Lewis, Mark G., Montefiori, David C., Sempowski, Gregory D., Baric, Ralph S., Acharya, Priyamvada, Haynes, Barton F., and Saunders, Kevin O.

Published
2021
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22. COVID-19-neutralizing antibodies predict disease severity and survival

Author

Garcia-Beltran, Wilfredo F., Lam, Evan C., Astudillo, Michael G., Yang, Diane, Miller, Tyler E., Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Clayton, Kiera L., Nitido, Adam D., Murali, Mandakolathur R., Alter, Galit, Charles, Richelle C., Dighe, Anand, Branda, John A., Lennerz, Jochen K., Lingwood, Daniel, Schmidt, Aaron G., Iafrate, A. John, and Balazs, Alejandro B.

Published
2021
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23. HYPERACUTE CUTIBACTERIUM ACNES ENDOPHTHALMITIS AFTER CATARACT SURGERY.

Author

Hauser, Blake M., Hoyek, Sandra, Greenstein, Scott H., and Patel, Nimesh A.

Abstract

Purpose: Postoperative endophthalmitis is a relatively uncommon, but potentially visually devastating, complication associated with cataract surgery. Specific microbial causes of endophthalmitis are characteristically associated with particular disease time courses. Although Cutibacterium acnes is typically associated with an indolent course of inflammation, we report a case of C. acnes endophthalmitis with onset on postoperative day (POD) 1 and a positive culture from POD 2. Methods: This is a case report. Results: A 56-year-old man underwent cataract extraction and posterior chamber intraocular lens placement in his left eye. On POD 1, he presented with severe discomfort, reduced visual acuity, and significant inflammation. On POD 2, his anterior chamber was tapped and injected with broad-spectrum antibiotics and steroids. The inflammation ultimately resolved, and his visual acuity improved to 20/20. Conclusion: C. acnes is a rare cause of hyperacute-onset postoperative endophthalmitis. Maintaining a high clinical suspicion and initiating prompt treatment can help to optimize long-term visual outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production

Author

Chen, Yuezhou, Zuiani, Adam, Fischinger, Stephanie, Mullur, Jyotsna, Atyeo, Caroline, Travers, Meghan, Lelis, Felipe J.N., Pullen, Krista M., Martin, Hannah, Tong, Pei, Gautam, Avneesh, Habibi, Shaghayegh, Bensko, Jillian, Gakpo, Deborah, Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Cai, Yongfei, Burke, John S., Lin, Junrui, Lederer, James A., Lam, Evan Christopher, Lavine, Christy L., Seaman, Michael S., Chen, Bing, Schmidt, Aaron G., Balazs, Alejandro Benjamin, Lauffenburger, Douglas A., Alter, Galit, and Wesemann, Duane R.

Published
2020
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25. Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19

Author

Kaneko, Naoki, Kuo, Hsiao-Hsuan, Boucau, Julie, Farmer, Jocelyn R., Allard-Chamard, Hugues, Mahajan, Vinay S., Piechocka-Trocha, Alicja, Lefteri, Kristina, Osborn, Matthew, Bals, Julia, Bartsch, Yannic C., Bonheur, Nathalie, Caradonna, Timothy M., Chevalier, Josh, Chowdhury, Fatema, Diefenbach, Thomas J., Einkauf, Kevin, Fallon, Jon, Feldman, Jared, Finn, Kelsey K., Garcia-Broncano, Pilar, Hartana, Ciputra Adijaya, Hauser, Blake M., Jiang, Chenyang, Kaplonek, Paulina, Karpell, Marshall, Koscher, Eric C., Lian, Xiaodong, Liu, Hang, Liu, Jinqing, Ly, Ngoc L., Michell, Ashlin R., Rassadkina, Yelizaveta, Seiger, Kyra, Sessa, Libera, Shin, Sally, Singh, Nishant, Sun, Weiwei, Sun, Xiaoming, Ticheli, Hannah J., Waring, Michael T., Zhu, Alex L., Alter, Galit, Li, Jonathan Z., Lingwood, Daniel, Schmidt, Aaron G., Lichterfeld, Mathias, Walker, Bruce D., Yu, Xu G., Padera, Robert F., Jr., and Pillai, Shiv

Published
2020
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27. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

Author

Banovich, Nicholas, Barbry, Pascal, Brazma, Alvis, Desai, Tushar, Duong, Thu Elizabeth, Eickelberg, Oliver, Falk, Christine, Farzan, Michael, Glass, Ian, Haniffa, Muzlifah, Horvath, Peter, Hung, Deborah, Kaminski, Naftali, Krasnow, Mark, Kropski, Jonathan A., Kuhnemund, Malte, Lafyatis, Robert, Lee, Haeock, Leroy, Sylvie, Linnarson, Sten, Lundeberg, Joakim, Meyer, Kerstin, Misharin, Alexander, Nawijn, Martijn, Nikolic, Marko Z., Ordovas-Montanes, Jose, Pe’er, Dana, Powell, Joseph, Quake, Stephen, Rajagopal, Jay, Tata, Purushothama Rao, Rawlins, Emma L., Regev, Aviv, Reyfman, Paul A., Rojas, Mauricio, Rosen, Orit, Saeb-Parsy, Kourosh, Samakovlis, Christos, Schiller, Herbert, Schultze, Joachim L., Seibold, Max A., Shalek, Alex K., Shepherd, Douglas, Spence, Jason, Spira, Avrum, Sun, Xin, Teichmann, Sarah, Theis, Fabian, Tsankov, Alexander, van den Berge, Maarten, von Papen, Michael, Whitsett, Jeffrey, Xavier, Ramnik, Xu, Yan, Zaragosi, Laure-Emmanuelle, Zhang, Kun, Ziegler, Carly G.K., Allon, Samuel J., Nyquist, Sarah K., Mbano, Ian M., Miao, Vincent N., Tzouanas, Constantine N., Cao, Yuming, Yousif, Ashraf S., Bals, Julia, Hauser, Blake M., Feldman, Jared, Muus, Christoph, Wadsworth, Marc H., II, Kazer, Samuel W., Hughes, Travis K., Doran, Benjamin, Gatter, G. James, Vukovic, Marko, Taliaferro, Faith, Mead, Benjamin E., Guo, Zhiru, Wang, Jennifer P., Gras, Delphine, Plaisant, Magali, Ansari, Meshal, Angelidis, Ilias, Adler, Heiko, Sucre, Jennifer M.S., Taylor, Chase J., Lin, Brian, Waghray, Avinash, Mitsialis, Vanessa, Dwyer, Daniel F., Buchheit, Kathleen M., Boyce, Joshua A., Barrett, Nora A., Laidlaw, Tanya M., Carroll, Shaina L., Colonna, Lucrezia, Tkachev, Victor, Peterson, Christopher W., Yu, Alison, Zheng, Hengqi Betty, Gideon, Hannah P., Winchell, Caylin G., Lin, Philana Ling, Bingle, Colin D., Snapper, Scott B., Theis, Fabian J., Schiller, Herbert B., Leslie, Alasdair, Kiem, Hans-Peter, Flynn, JoAnne L., Fortune, Sarah M., Berger, Bonnie, Finberg, Robert W., Kean, Leslie S., Garber, Manuel, Schmidt, Aaron G., and Lingwood, Daniel

Published
2020
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28. Sequence Analysis of Inducible, Replication-Competent Virus Reveals No Evidence of HIV-1 Evolution During Suppressive Antiviral Therapy Indicating A Lack Of Ongoing Viral Replication

Author

Lee, Sook-Kyung, primary, Sondgeroth, Amy, additional, Xu, Yinyan, additional, Warren, Joanna, additional, Zhou, Shuntai, additional, Gilleece, Maria, additional, Hauser, Blake M, additional, Gay, Cynthia L, additional, Kuruc, JoAnn D, additional, Archin, Nancie M, additional, Eron, Joseph J, additional, Margolis, David M, additional, Goonetilleke, Nilu, additional, and Swanstrom, Ronald, additional

Published
2024
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29. Improving Medical Student Access to Nutrition During the Core Surgery Clerkship.

Author

Hauser, Blake M., Parsons, Matthew, Alija, Besmira, Kim, Christine, Nguyen, Andrew, Moses, Joy, Tseng, Sierra, Alba, Christopher, Dédé, Kniya, Gimmen, Megan, Silva, Evelyn Lemus, Rajesh, Diviya, Mirfakhraie, Lily, Yang, Alan Z., Ariagno, Meghan, Moutsioulis, Kelly, Reilly, Erin, Askari, Reza, Cho, Nancy L., and Evenson, Amy

Subjects
SCALE analysis (Psychology), HUMAN services programs, FOOD security, EVALUATION of human services programs, PILOT projects, HEALTH, DESCRIPTIVE statistics, MEDICAL students, OPERATIVE surgery, LUNCHEONS, METROPOLITAN areas, SNACK foods, STUDENT attitudes, HEALTH promotion, MEALS, NUTRITION
Abstract

The rigorous demands of medical education create circumstances that can make it challenging to maintain a healthy diet. Evaluations from students at an urban medical school in the northeast U.S. regarding their surgery clerkship highlighted the difficulty of finding healthy snacks or meals between operations and patient care obligations. In response, we implemented the Nutritional Wellness Initiative, a pilot program designed to offer accessible, healthy snacks to medical students during their surgery clerkship. We conducted a 3-month pilot program at three hospital sites and surveyed participants. Responses were compared to controls who completed their surgery rotation before initiation of the pilot program. Both groups emphasized the importance of having access to food during the workday for student wellness, with less than 50% of students in either group eating lunch daily during the surgery rotation. Of students who participated in the pilot program, 63% used the provided snacks at least once per week. This model offers one approach to improving student access to nutritious snacks during the busy surgery workday. To improve our program going forward, we have engaged the Director of Lifestyle Medicine and Wellness in the Department of Surgery to help optimize nutritional delivery and to create student education resources regarding healthy snacking habits and choices. [ABSTRACT FROM AUTHOR]

Published
2025
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31. Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters

Author

Tostanoski, Lisa H., Wegmann, Frank, Martinot, Amanda J., Loos, Carolin, McMahan, Katherine, Mercado, Noe B., Yu, Jingyou, Chan, Chi N., Bondoc, Stephen, Starke, Carly E., Nekorchuk, Michael, Busman-Sahay, Kathleen, Piedra-Mora, Cesar, Wrijil, Linda M., Ducat, Sarah, Custers, Jerome, Atyeo, Caroline, Fischinger, Stephanie, Burke, John S., Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Bondzie, Esther A., Dagotto, Gabriel, Gebre, Makda S., Jacob-Dolan, Catherine, Lin, Zijin, Mahrokhian, Shant H., Nampanya, Felix, Nityanandam, Ramya, Pessaint, Laurent, Porto, Maciel, Ali, Vaneesha, Benetiene, Dalia, Tevi, Komlan, Andersen, Hanne, Lewis, Mark G., Schmidt, Aaron G., Lauffenburger, Douglas A., Alter, Galit, Estes, Jacob D., Schuitemaker, Hanneke, Zahn, Roland, and Barouch, Dan H.

Published
2020
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32. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

Author

Mercado, Noe B., Zahn, Roland, Wegmann, Frank, Loos, Carolin, Chandrashekar, Abishek, Yu, Jingyou, Liu, Jinyan, Peter, Lauren, McMahan, Katherine, Tostanoski, Lisa H., He, Xuan, Martinez, David R., Rutten, Lucy, Bos, Rinke, van Manen, Danielle, Vellinga, Jort, Custers, Jerome, Langedijk, Johannes P., Kwaks, Ted, Bakkers, Mark J. G., Zuijdgeest, David, Rosendahl Huber, Sietske K., Atyeo, Caroline, Fischinger, Stephanie, Burke, John S., Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Bondzie, Esther A., Dagotto, Gabriel, Gebre, Makda S., Hoffman, Emily, Jacob-Dolan, Catherine, Kirilova, Marinela, Li, Zhenfeng, Lin, Zijin, Mahrokhian, Shant H., Maxfield, Lori F., Nampanya, Felix, Nityanandam, Ramya, Nkolola, Joseph P., Patel, Shivani, Ventura, John D., Verrington, Kaylee, Wan, Huahua, Pessaint, Laurent, Van Ry, Alex, Blade, Kelvin, Strasbaugh, Amanda, Cabus, Mehtap, Brown, Renita, Cook, Anthony, Zouantchangadou, Serge, Teow, Elyse, Andersen, Hanne, Lewis, Mark G., Cai, Yongfei, Chen, Bing, Schmidt, Aaron G., Reeves, R. Keith, Baric, Ralph S., Lauffenburger, Douglas A., Alter, Galit, Stoffels, Paul, Mammen, Mathai, Van Hoof, Johan, Schuitemaker, Hanneke, and Barouch, Dan H.

Published
2020
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34. Next Generation of Global Surgeons: Aligning Interest With Early Access to Global Surgery Education

Author

Acker, Rachael, Aharon, Shani, Alty, Isaac, Anyanwu, Chikamuche, Beck, Nicole, Brandt, Alyssa, Briggs, Logan, Caminita, Christena, Chaet, Alexis, Chan, Jonathan, Chiu, Lucinda, Cueto, Carmen, Daneshdoost, Shanaz, Edalatpour, Roya, Garba, Deen, Giles, Andrew E., Gualy, Sebastian, Haider, Ali, Hamilton, Charles, Hauser, Blake M., He, Puhan, Im, Chaewon, Jayaram, Anusha, Jhun, Ray, Joshi, Avina, Kahanu, Alexis, Kim, Na Eun, Kim, Raymond, Lauffer, Sam, McHargue, Cody, Meeks, Monica, Mehta, Ambar, Mendoza, Ardi, Miller, Matt, Nourian, Maziar, Ottesen, Taylor D., Patel, Prachi, Peck, Connor J., Pyarali, Monika, Ramirez, Adriana G., Rehman, Shahyan, Shankar, Bairavi, Stetson, Alyssa, Still, Megan E.H., Tutunjian, Alyssa, Yibrehu, Betel, Yu, Kristin E., Scott, Erin M., Fallah, Parisa N., Blitzer, David N., NeMoyer, Rachel E., Sifri, Ziad, Hanna, Joseph S., and Peck, Gregory L.

Published
2019
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35. Does the Association Between Psychosocial Factors and Opioid Use After Elective Spine Surgery Differ by Sex in Older Adults?

Author

Aglio, Linda, primary, Mezzalira, Elisabetta, additional, Corey, Sarah M, additional, Fields, Kara G, additional, Hauser, Blake M, additional, Susano, Maria, additional, Culley, Deborah, additional, Schreiber, Kristin, additional, Kelly-Aglio, Nicole, additional, Patton, Megan, additional, Mekary, Rania, additional, and Edwards, Robert, additional

Published
2023
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36. Characterization of SARS-CoV-2 Convalescent Patients’ Serological Repertoire Reveals High Prevalence of Iso–RBD Antibodies

Author

Curtis, Nicholas C., primary, Shin, Seungmin, additional, Hederman, Andrew P., additional, Connor, Ruth I., additional, Wieland-Alter, Wendy F., additional, Ionov, Steven, additional, Boylston, Jennifer, additional, Rose, Josh, additional, Sakharkar, Mrunal, additional, Dorman, Dana B., additional, Dessaint, John A., additional, Gwilt, Lorraine L., additional, Crowley, Andrew R., additional, Feldman, Jared, additional, Hauser, Blake M., additional, Schmidt, Aaron G., additional, Ashare, Alix, additional, Walker, Laura M., additional, Wright, Peter F., additional, Ackerman, Margaret E., additional, and Lee, Jiwon, additional

Published
2023
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41. Lectin Fingerprinting Distinguishes Antibody Neutralization in SARS-CoV-2

Author

Wuo, Michael G., primary, Dugan, Amanda E., additional, Halim, Melanie, additional, Hauser, Blake M., additional, Feldman, Jared, additional, Caradonna, Timothy M., additional, Zhang, Shuting, additional, Pepi, Lauren E., additional, Atyeo, Caroline, additional, Fischinger, Stephanie, additional, Alter, Galit, additional, Garcia-Beltran, Wilfredo F., additional, Azadi, Parastoo, additional, Hung, Deb, additional, Schmidt, Aaron G., additional, and Kiessling, Laura L., additional

Published
2023
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43. Does the Association Between Psychosocial Factors and Opioid Use After Elective Spine Surgery Differ by Sex in Older Adults?

Author

Aglio,Linda, Mezzalira,Elisabetta, Corey,Sarah M, Fields,Kara G, Hauser,Blake M, Susano,Maria, Culley,Deborah, Schreiber,Kristin, Kelly-Aglio,Nicole, Patton,Megan, Mekary,Rania, Edwards,Robert, Aglio,Linda, Mezzalira,Elisabetta, Corey,Sarah M, Fields,Kara G, Hauser,Blake M, Susano,Maria, Culley,Deborah, Schreiber,Kristin, Kelly-Aglio,Nicole, Patton,Megan, Mekary,Rania, and Edwards,Robert

Abstract

Linda S Aglio,1,2,* Elisabetta Mezzalira,2,3,* Sarah M Corey,1 Kara G Fields,1 Blake M Hauser,4 Maria J Susano,5 Deborah J Culley,1 Kristin L Schreiber,1 Nicole J Kelly-Aglio,2 Megan E Patton,1 Rania A Mekary,2,6 Robert R Edwards1 1Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Boston, MA, USA; 2Computational Neurosurgical Outcome Center, Department of Neurosurgery, Brigham and Women’s Hospital, Boston, MA, USA; 3Department of Diagnostics and Public Health, University of Verona, Verona, Italy; 4Harvard-Massachusetts Institute of Technology Program in Health Sciences and Technology, Cambridge, MA, USA; 5Department of Anesthesiology, Emergency and Critical Care, Centro Hospitalar do Porto, Porto, Portugal; 6School of Pharmacy, Massachusetts College of Pharmacy and Health Sciences (MCPHS) University, Boston, MA, USA*These authors contributed equally to this workCorrespondence: Linda S Aglio, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Boston, MA, USA, Tel +1-617-732-8280, Fax +1-617-264-5230, Email laglio@bwh.harvard.eduPurpose: Psychosocial disorders have been linked to chronic postoperative opioid use and the development of postoperative pain. The potential interaction between sex and psychosocial factors with respect to opioid use after elective spine surgery in the elderly has not yet been evaluated. Our aim was to assess whether any observed association of anxiety or depression indicators with opioid consumption in the first 72 hours after elective spine surgery varies by sex in adults ≥ 65 years.Patients and Methods: Secondary analysis of a retrospective cohort of 647 elective spine surgeries performed at Brigham and Women’s Hospital, July 1, 2015–March 15, 2017, in patients ≥ 65. Linear mixed-effects models were used to test whether history of anxiety, anxiolytic use, history of depression, and antidepressant use were associated wi

Published
2023

46. Publisher Correction: Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

Author

Mercado, Noe B., Zahn, Roland, Wegmann, Frank, Loos, Carolin, Chandrashekar, Abishek, Yu, Jingyou, Liu, Jinyan, Peter, Lauren, McMahan, Katherine, Tostanoski, Lisa H., He, Xuan, Martinez, David R., Rutten, Lucy, Bos, Rinke, van Manen, Danielle, Vellinga, Jort, Custers, Jerome, Langedijk, Johannes P., Kwaks, Ted, Bakkers, Mark J. G., Zuijdgeest, David, Huber, Sietske K. Rosendahl, Atyeo, Caroline, Fischinger, Stephanie, Burke, John S., Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Bondzie, Esther A., Dagotto, Gabriel, Gebre, Makda S., Hoffman, Emily, Jacob-Dolan, Catherine, Kirilova, Marinela, Li, Zhenfeng, Lin, Zijin, Mahrokhian, Shant H., Maxfield, Lori F., Nampanya, Felix, Nityanandam, Ramya, Nkolola, Joseph P., Patel, Shivani, Ventura, John D., Verrington, Kaylee, Wan, Huahua, Pessaint, Laurent, Van Ry, Alex, Blade, Kelvin, Strasbaugh, Amanda, Cabus, Mehtap, Brown, Renita, Cook, Anthony, Zouantchangadou, Serge, Teow, Elyse, Andersen, Hanne, Lewis, Mark G., Cai, Yongfei, Chen, Bing, Schmidt, Aaron G., Reeves, R. Keith, Baric, Ralph S., Lauffenburger, Douglas A., Alter, Galit, Stoffels, Paul, Mammen, Mathai, Van Hoof, Johan, Schuitemaker, Hanneke, and Barouch, Dan H.

Published
2021
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47. Reduced time to imaging, length of stay, and hospital charges following implementation of a novel postoperative pathway for craniotomy

Author

Hoffman, Samantha E., primary, Gupta, Saksham, additional, O’Connor, Matthew, additional, Jarvis, Casey A., additional, Zhao, Maryann, additional, Hauser, Blake M., additional, Bernstock, Joshua D., additional, Murphy, Shayna, additional, Raftery, Siobhan M., additional, Lane, Karen, additional, Chiocca, E. Antonio, additional, and Arnaout, Omar, additional

Published
2023
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48. Cross-reactive SARS-CoV-2 epitope targeted across donors informs immunogen design

Author

Hauser, Blake M., primary, Feldman, Jared, additional, Sangesland, Maya, additional, Ronsard, Larance, additional, St. Denis, Kerri J., additional, Sheehan, Maegan L., additional, Cao, Yi, additional, Boucau, Julie, additional, Windsor, Ian W., additional, Cheng, Agnes H., additional, Vu, Mya L., additional, Cardoso, Marcella R., additional, Kannegieter, Ty, additional, Balazs, Alejandro B., additional, Lingwood, Daniel, additional, Garcia-Beltran, Wilfredo F., additional, and Schmidt, Aaron G., additional

Published
2022
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49. Antibodies as drugs—a Keystone Symposia report

Author

Cable, Jennifer, primary, Saphire, Erica Ollmann, additional, Hayday, Adrian C., additional, Wiltshire, Timothy D., additional, Mousa, Jarrod J., additional, Humphreys, David P., additional, Breij, Esther C. W., additional, Bruhns, Pierre, additional, Broketa, Matteo, additional, Furuya, Genta, additional, Hauser, Blake M., additional, Mahévas, Matthieu, additional, Carfi, Andrea, additional, Cantaert, Tineke, additional, Kwong, Peter D., additional, Tripathi, Prabhanshu, additional, Davis, Jonathan H., additional, Brewis, Neil, additional, Keyt, Bruce A., additional, Fennemann, Felix L., additional, Dussupt, Vincent, additional, Sivasubramanian, Arvind, additional, Kim, Philip M., additional, Rawi, Reda, additional, Richardson, Eve, additional, Leventhal, Daniel, additional, Wolters, Rachael M., additional, Geuijen, Cecile A. W., additional, Sleeman, Matthew A., additional, Pengo, Niccolo, additional, and Donnellan, Francesca Rose, additional

Published
2022
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50. Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses

Author

Tas, Jeroen M.J., primary, Koo, Ja-Hyun, additional, Lin, Ying-Cing, additional, Xie, Zhenfei, additional, Steichen, Jon M., additional, Jackson, Abigail M., additional, Hauser, Blake M., additional, Wang, Xuesong, additional, Cottrell, Christopher A., additional, Torres, Jonathan L., additional, Warner, John E., additional, Kirsch, Kathrin H., additional, Weldon, Stephanie R., additional, Groschel, Bettina, additional, Nogal, Bartek, additional, Ozorowski, Gabriel, additional, Bangaru, Sandhya, additional, Phelps, Nicole, additional, Adachi, Yumiko, additional, Eskandarzadeh, Saman, additional, Kubitz, Michael, additional, Burton, Dennis R., additional, Lingwood, Daniel, additional, Schmidt, Aaron G., additional, Nair, Usha, additional, Ward, Andrew B., additional, Schief, William R., additional, and Batista, Facundo D., additional

Published
2022
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