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21 results on '"Haug, L.S."'

2. PFAS levels and exposure determinants in sensitive population groups

Author

Fábelová, L., Beneito, A., Casas, M., Colles, A., Dalsager, L., Den Hond, E., Dereumeaux, C., Ferguson, K., Gilles, L., Govarts, E., Irizar, A., Lopez Espinosa, M.J., Montazeri, P., Morrens, B., Patayová, H., Rausová, K., Richterová, D., Rodriguez Martin, L., Santa-Marina, L., Schettgen, T., Schoeters, G., Haug, L.S., Uhl, M., Villanger, G.D., Vrijheid, M., Zaros, C., and Palkovičová Murínová, Ľ

Published
2023
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3. Approaches to mixture risk assessment of PFASs in the European population based on human hazard and biomonitoring data

Author

Bil, W., Govarts, E., Zeilmaker, M.J., Woutersen, M., Bessems, J., Ma, Y., Thomsen, C., Haug, L.S., Lignell, S., Gyllenhammar, I., Palkovicova Murinova, L., Fabelova, L., Tratnik, J. Snoj, Kosjek, T., Gabriel, C., Sarigiannis, D., Pedraza-Diaz, S., Esteban-López, M., Castaño, A., Rambaud, L., Riou, M., Franken, C., Colles, A., Vogel, N., Kolossa-Gehring, M., Halldorsson, T.I., Uhl, M., Schoeters, G., Santonen, T., and Vinggaard, A.M.

Published
2023
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4. PFAS levels and determinants of variability in exposure in European teenagers – Results from the HBM4EU aligned studies (2014–2021)

Author

Richterová, D., Govarts, E., Fábelová, L., Rausová, K., Rodriguez Martin, L., Gilles, L., Remy, S., Colles, A., Rambaud, L., Riou, M., Gabriel, C., Sarigiannis, D., Pedraza-Diaz, S., Ramos, J.J., Kosjek, T., Snoj Tratnik, J., Lignell, S., Gyllenhammar, I., Thomsen, C., Haug, L.S., Kolossa-Gehring, M., Vogel, N., Franken, C., Vanlarebeke, N., Bruckers, L., Stewart, L., Sepai, O., Schoeters, G., Uhl, M., Castaño, A., Esteban López, M., Göen, T., and Palkovičová Murínová, Ľ.

Published
2023
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16. Approaches to mixture risk assessment of PFASs in the European population based on human hazard and biomonitoring data

Author

Bil, W., Govarts, E., Zeilmaker, M.J., Woutersen, M., Bessems, J., Ma, Y., Thomsen, C., Haug, L.S., Lignell, S., Gyllenhammar, I., Palkovicova Murinova, L., Fabelova, L., Tratnik, J. Snoj, Kosjek, T., Gabriel, C., Sarigiannis, D., Pedraza-Diaz, S., Esteban-López, M., Castaño, A., Rambaud, L., Riou, M., Franken, C., Colles, A., Vogel, N., Kolossa-Gehring, M., Halldorsson, T.I., Uhl, M., Schoeters, G., Santonen, T., Vinggaard, A.M., Unión Europea. Comisión Europea. H2020, Norwegian Institute of Public Health, The Research Council of Norway, and Ministry of Health (República Checa)

Subjects
HBM4EU, Fluorocarbons, Food Safety, Adolescent, PFAS, Mixture, Public Health, Environmental and Occupational Health, Humans, Blood concentration, Risk Assessment, Bioaccumulation, Biological Monitoring
Abstract

Per- and polyfluoroalkyl substances (PFASs) are a highly persistent, mobile, and bioaccumulative class of chemicals, of which emissions into the environment result in long-lasting contamination with high probability for causing adverse effects to human health and the environment. Within the European Biomonitoring Initiative HBM4EU, samples and data were collected in a harmonized way from human biomonitoring (HBM) studies in Europe to derive current exposure data across a geographic spread. We performed mixture risk assessments based on recent internal exposure data of PFASs in European teenagers generated in the HBM4EU Aligned Studies (dataset with N = 1957, sampling years 2014-2021). Mixture risk assessments were performed based on three hazard-based approaches: the Hazard Index (HI) approach, the sum value approach as used by the European Food Safety Authority (EFSA) and the Relative Potency Factor (RPF) approach. The HI approach resulted in the highest risk estimates, followed by the RPF approach and the sum value approach. The assessments indicate that PFAS exposure may result in a health risk in a considerable fraction of individuals in the HBM4EU teenager study sample, thereby confirming the conclusion drawn in the recent EFSA scientific opinion. This study underlines that HBM data are of added value in assessing the health risks of aggregate and cumulative exposure to PFASs, as such data are able to reflect exposure from different sources and via different routes. This work was supported by the European Union’s Horizon 2020 research and innovation programme under Grant agreement No 733032 HBM4EU (www.HBM4EU.eu), and received co-funding from the au thors’ organizations. The Norwegian Institute of Public Health (NIPH) has contributed to funding of the Norwegian Environmental Biobank (NEB), and the laboratory measurements have partly been funded by the Research Council of Norway through research projects (275903 and 268465). The PCB cohort (follow-up) received additional funding from the Ministry of Health of the Slovak Republic (program 07B0103). Sí

Published
2022
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19. Prenatal Exposure to Air Pollution and Traffic and the Risk of Child Liver Injury in European Children-The HELIX Project

Author

Garcia, E., primary, Stratakis, N., additional, Valvi, D., additional, Maitre, L., additional, Varo, N., additional, Basagana, X., additional, de Castro, M., additional, Fossati, S., additional, Grazuleviciene, R., additional, Haug, L.S., additional, Heude, B., additional, McEachan, R., additional, Nieuwenhuijsen, M., additional, Papadopoulou, E., additional, Roumeliotaki, T., additional, Slama, R., additional, Urquiza, J., additional, Vafeiadi, M., additional, Vos, M.B., additional, Wright, J., additional, Conti, D.V., additional, Berhane, K., additional, Chatzi, M., additional, McConnell, R., additional, and Chatzi, L., additional

Published
2020
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20. Zürich statement on future actions on per- and polyfluoroalkyl substances (PFASs)

Author

Ritscher, A., Wang, Z., Scheringer, M., Boucher, J.M., Ahrens, L., Berger, Urs, Bintein, S., Bopp, S.K., Borg, D., Buser, A.M., Cousins, I., DeWitt, J., Fletcher, T., Green, C., Herzke, D., Higgins, C., Huang, J., Hung, H., Knepper, T., Lau, C.S., Leinala, E., Lindstrom, A.B., Liu, J., Miller, M., Ohno, K., Perkola, N., Shi, Y., Haug, L.S., Trier, X., Valsecchi, S., van der Jagt, K., Vierke, L., Ritscher, A., Wang, Z., Scheringer, M., Boucher, J.M., Ahrens, L., Berger, Urs, Bintein, S., Bopp, S.K., Borg, D., Buser, A.M., Cousins, I., DeWitt, J., Fletcher, T., Green, C., Herzke, D., Higgins, C., Huang, J., Hung, H., Knepper, T., Lau, C.S., Leinala, E., Lindstrom, A.B., Liu, J., Miller, M., Ohno, K., Perkola, N., Shi, Y., Haug, L.S., Trier, X., Valsecchi, S., van der Jagt, K., and Vierke, L.

Abstract

Per- and polyfluoroalkyl substances (PFASs) are man-made chemicals that contain at least one perfluoroalkyl moiety, –CnF2n–. To date, over 4,000 unique PFASs have been used in technical applications and consumer products, and some of them have been detected globally in human and wildlife biomonitoring studies. Because of their extraordinary persistence, human and environmental exposure to PFASs will be a long-term source of concern. Some PFASs such as perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) have been investigated extensively and thus regulated, but for many other PFASs, knowledge about their current uses and hazards is still very limited or missing entirely. To address this problem and prepare an action plan for the assessment and management of PFASs in the coming years, a group of more than 50 international scientists and regulators held a two-day workshop in November, 2017. The group identified both the respective needs of and common goals shared by the scientific and the policy communities, made recommendations for cooperative actions, and outlined how the science–policy interface regarding PFASs can be strengthened using new approaches for assessing and managing highly persistent chemicals such as PFASs.

Published
2018

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