48 results on '"Hauer R. N. W."'
Search Results
2. Recurrent and founder mutations in the Netherlands: Plakophilin-2 p.Arg79X mutation causing arrhythmogenic right ventricular cardiomyopathy/dysplasia*
- Author
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van der Zwaag, P. A., Cox, M. G. P. J., van der Werf, C., Wiesfeld, A. C. P., Jongbloed, J. D. H., Dooijes, D., Bikker, H., Jongbloed, R., Suurmeijer, A. J. H., van den Berg, M. P., Hofstra, R. M. W., Hauer, R. N. W., Wilde, A. A. M., van Tintelen, J. P., Wilde, Arthur A.M., editor, and van Tintelen, J. Peter, editor
- Published
- 2014
- Full Text
- View/download PDF
3. Idiopathic Atrial Fibrillation: Which Electrophysiological Substrate?
- Author
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Hauer, R. N. W. and Raviele, Antonio, editor
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- 2006
- Full Text
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4. Brugada Syndrome or Brugada Mimicry?
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Hauer, R. N. W. and Raviele, Antonio, editor
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- 2004
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5. Idiopathic Ventricular Fibrillation: Is the Prognosis Always Bad?
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Hauer, R. N. W., Remme, C. A., and Raviele, Antonio, editor
- Published
- 2000
- Full Text
- View/download PDF
6. Recurrent and founder mutations in the Netherlands—Phospholamban p.Arg14del mutation causes arrhythmogenic cardiomyopathy
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van der Zwaag, P. A., van Rijsingen, I. A. W., de Ruiter, R., Nannenberg, E. A., Groeneweg, J. A., Post, J. G., Hauer, R. N. W., van Gelder, I. C., van den Berg, M. P., van der Harst, P., Wilde, A. A. M., and van Tintelen, J. P.
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- 2013
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7. Geographical distribution of plakophilin-2 mutation prevalence in patients with arrhythmogenic cardiomyopathy
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Jacob, K. A., Noorman, M., Cox, M. G. P. J., Groeneweg, J. A., Hauer, R. N. W., and van der Heyden, M. A. G.
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- 2012
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8. Infection after ICD implantation: operating room versus cardiac catheterisation laboratory
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Remmelts, H. H. F., Meine, M., Loh, P., Hauer, R. N. W., Doevendans, P. A., van Herwerden, L. A., Hopmans, T. E. M., and Ellerbroek, P. M.
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- 2009
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9. Arrhythmogenic right ventricular cardiomyopathy: asymptomatic to life threatening as illustrated by the cases of two sisters
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Otterspoor, L. C., Reichert, C. L. A., Cramer, M. J. M., Bhuiyan, Z. A., Wilde, A. A. M., and Hauer, R. N. W.
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- 2007
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10. Cadherin 2-Related Arrhythmogenic Cardiomyopathy: Prevalence and Clinical Features
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Ghidoni, A, Elliott, P, Syrris, P, Calkins, H, James, C, Judge, D, Murray, B, Barc, J, Probst, V, Schott, J, Song, J, Hauer, R, Hoorntje, E, Van Tintelen, J, Schulze-Bahr, E, Hamilton, R, Mittal, K, Semsarian, C, Behr, E, Ackerman, M, Basso, C, Parati, G, Gentilini, D, Kotta, M, Mayosi, B, Schwartz, P, Crotti, L, Ghidoni A., Elliott P. M., Syrris P., Calkins H., James C. A., Judge D. P., Murray B., Barc J., Probst V., Schott J. J., Song J. -P., Hauer R. N. W., Hoorntje E. T., Van Tintelen J. P., Schulze-Bahr E., Hamilton R. M., Mittal K., Semsarian C., Behr E. R., Ackerman M. J., Basso C., Parati G., Gentilini D., Kotta M. -C., Mayosi B. M., Schwartz P. J., Crotti L., Ghidoni, A, Elliott, P, Syrris, P, Calkins, H, James, C, Judge, D, Murray, B, Barc, J, Probst, V, Schott, J, Song, J, Hauer, R, Hoorntje, E, Van Tintelen, J, Schulze-Bahr, E, Hamilton, R, Mittal, K, Semsarian, C, Behr, E, Ackerman, M, Basso, C, Parati, G, Gentilini, D, Kotta, M, Mayosi, B, Schwartz, P, Crotti, L, Ghidoni A., Elliott P. M., Syrris P., Calkins H., James C. A., Judge D. P., Murray B., Barc J., Probst V., Schott J. J., Song J. -P., Hauer R. N. W., Hoorntje E. T., Van Tintelen J. P., Schulze-Bahr E., Hamilton R. M., Mittal K., Semsarian C., Behr E. R., Ackerman M. J., Basso C., Parati G., Gentilini D., Kotta M. -C., Mayosi B. M., Schwartz P. J., and Crotti L.
- Abstract
Background: Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disease characterized by fibrofatty replacement of the right and left ventricle, often causing ventricular dysfunction and life-threatening arrhythmias. Variants in desmosomal genes account for up to 60% of cases. Our objective was to establish the prevalence and clinical features of ACM stemming from pathogenic variants in the nondesmosomal cadherin 2 (CDH2), a novel genetic substrate of ACM. Methods: A cohort of 500 unrelated patients with a definite diagnosis of ACM and no disease-causing variants in the main ACM genes was assembled. Genetic screening of CDH2 was performed through next-generation or Sanger sequencing. Whenever possible, cascade screening was initiated in the families of CDH2-positive probands, and clinical evaluation was performed. Results: Genetic screening of CDH2 led to the identification of 7 rare variants: 5, identified in 6 probands, were classified as pathogenic or likely pathogenic. The previously established p.D407N pathogenic variant was detected in 2 additional probands. Probands and family members with pathogenic/likely pathogenic variants in CDH2 were clinically evaluated, and along with previously published cases, altogether contributed to the identification of gene-specific features (13 cases from this cohort and 11 previously published, for a total of 9 probands and 15 family members). Ventricular arrhythmic events occurred in most CDH2-positive subjects (20/24, 83%), while the occurrence of heart failure was rare (2/24, 8.3%). Among probands, sustained ventricular tachycardia and sudden cardiac death occurred in 5/9 (56%). Conclusions: In this worldwide cohort of previously genotype-negative ACM patients, the prevalence of probands with CDH2 pathogenic/likely pathogenic variants was 1.2% (6/500). Our data show that this cohort of CDH2-ACM patients has a high incidence of ventricular arrhythmias, while evolution toward heart failure is rare.
- Published
- 2021
11. Recurrent and founder mutations in the Netherlands – Phospholamban p.Arg14del mutation causes arrhythmogenic cardiomyopathy*
- Author
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van der Zwaag, P. A., primary, van Rijsingen, I. A. W., additional, de Ruiter, R., additional, Nannenberg, E. A., additional, Groeneweg, J. A., additional, Post, J. G., additional, Hauer, R. N. W., additional, van Gelder, I. C., additional, van den Berg, M. P., additional, van der Harst, P., additional, Wilde, A. A. M., additional, and van Tintelen, J. P., additional
- Published
- 2014
- Full Text
- View/download PDF
12. Recurrent and founder mutations in the Netherlands: Plakophilin-2 p.Arg79X mutation causing arrhythmogenic right ventricular cardiomyopathy/dysplasia*
- Author
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van der Zwaag, P. A., primary, Cox, M. G. P. J., additional, van der Werf, C., additional, Wiesfeld, A. C. P., additional, Jongbloed, J. D. H., additional, Dooijes, D., additional, Bikker, H., additional, Jongbloed, R., additional, Suurmeijer, A. J. H., additional, van den Berg, M. P., additional, Hofstra, R. M. W., additional, Hauer, R. N. W., additional, Wilde, A. A. M., additional, and van Tintelen, J. P., additional
- Published
- 2014
- Full Text
- View/download PDF
13. Mark E. Josephson (1943–2017)
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Hauer, R. N. W.
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- 2017
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14. Surgical Revascularization in Patients with 'Ischemia-related' Ventricular Fibrillation: Is It Sufficient to Prevent Sudden Death?
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Hauer, R. N. W. and Raviele, Antonio, editor
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- 2004
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15. Rationale and design of a randomised controlled clinical trial on supplemental intake of n-3 fatty acids and incidence of cardiac arrhythmia: SOFA
- Author
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Brouwer, I A, Zock, P L, Wever, E F D, Hauer, R N W, Camm, A J, Böcker, D, Otto-Terlouw, P, Katan, M B, and Schouten, E G
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- 2003
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16. Interaction of flucloxacillin and quinidine
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Comuth, W. J., Comuth, J. A., Hauer, R. N. W., and Malingré, M. M.
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- 2012
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- View/download PDF
17. 33 Ventriculaire ritmestoornissen
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Hauer, R. N. W., primary
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- 2008
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18. Idiopathic Ventricular Fibrillation: Is the Prognosis Always Bad?
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Hauer, R. N. W., primary and Remme, C. A., additional
- Published
- 2000
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- View/download PDF
19. Change in delay of atrioventricular conduction after radiofrequency catheter ablation for atrioventricular nodal re-entry tachycardia
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Simmers, T. A., Wever, E. F. D., Wittkampf, F. H. M., and Hauer, R. N. W.
- Published
- 1995
20. The dawn of a new era in the struggle against sudden cardiac death
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Hauer, R. N. W.
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- 2009
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21. The Netherlands Arrhythmogenic Cardiomyopathy Registry: design and status update.
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Bosman, L. P., Verstraelen, T. E., van Lint, F. H. M., Cox, M. G. P. J., Groeneweg, J. A., Mast, T. P., van der Zwaag, P. A., Volders, P. G. A., Evertz, R., Wong, L., de Groot, N. M. S., Zeppenfeld, K., van der Heijden, J. F., van den Berg, M. P., Wilde, A. A. M., Asselbergs, F. W., Hauer, R. N. W., te Riele, A. S. J. M., van Tintelen, J. P., and Netherlands ACM Registry
- Subjects
CARDIOMYOPATHIES ,ARRHYTHMOGENIC right ventricular dysplasia ,EXPERIMENTAL design ,CARDIAC arrest ,PHYSICIANS - Abstract
Background: Clinical research on arrhythmogenic cardiomyopathy (ACM) is typically limited by small patient numbers, retrospective study designs, and inconsistent definitions. Aim: To create a large national ACM patient cohort with a vast amount of uniformly collected high-quality data that is readily available for future research. Methods: This is a multicentre, longitudinal, observational cohort study that includes (1) patients with a definite ACM diagnosis, (2) at-risk relatives of ACM patients, and (3) ACM-associated mutation carriers. At baseline and every follow-up visit, a medical history as well information regarding (non-)invasive tests is collected (e. g. electrocardiograms, Holter recordings, imaging and electrophysiological studies, pathology reports, etc.). Outcome data include (non-)sustained ventricular and atrial arrhythmias, heart failure, and (cardiac) death. Data are collected on a research electronic data capture (REDCap) platform in which every participating centre has its own restricted data access group, thus empowering local studies while facilitating data sharing. Discussion: The Netherlands ACM Registry is a national observational cohort study of ACM patients and relatives. Prospective and retrospective data are obtained at multiple time points, enabling both cross-sectional and longitudinal research in a hypothesis-generating approach that extends beyond one specific research question. In so doing, this registry aims to (1) increase the scientific knowledge base on disease mechanisms, genetics, and novel diagnostic and treatment strategies of ACM; and (2) provide education for physicians and patients concerning ACM, e. g. through our website (www.acmregistry.nl) and patient conferences. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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22. Conductive reserve and arrhythmias
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Stein, M., Boulaksil, M., Engelen, M. A., van Veen, T. A. B., Hauer, R. N. W., de Bakker, J. M. T., van Rijen, H. V. M., Amsterdam Cardiovascular Sciences, and Cardiology
- Published
- 2006
23. Sequential map-guided endocardial resection for ventricular tachycardia improves outcome
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Bakker, P. F. A., de Lange, F., Hauer, R. N. W., Derksen, R., de Bakker, J. M. T., van Hemel, N. M., Vermeulen, F. E. E., Intensive Care Medicine, Amsterdam Cardiovascular Sciences, and Cardiology
- Published
- 2005
24. Recommendations and cardiological evaluation of athletes with arrhythmias
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Hoogsteen, J. M., Bennekers, J. H., van der Wall, E. E., van Hemel, N. M., Wilde, A. A. M., Crijns, H. J. G. M., Gorgels, A. P. M., Smeets, J. L. R. M., Hauer, R. N. W., Jordaens, J. L. M., Schalij, M. J., and Cardiology
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- 2004
25. Idiopathic Atrial Fibrillation: Which Electrophysiological Substrate?
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Hauer, R. N. W., primary
- Full Text
- View/download PDF
26. The Brugada Numbers (reply to letter)
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Wilde, A. A. M., Antzelevitch, C., Borggrefe, M., Brugada, J., Brugada, P., Brugada, R., Towbin, J. A., Corrado, D., Hauer, R. N. W., Kass, R. S., Nademanee, K., Priori, S. G., and Cardiology
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- 2003
27. Mortality and risk factors for malignant ventricular arrhythmias in carriers of the phospholamban R14del mutation
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Van Der Zwaag, P. A., primary, Van Rijsingen, I. A. W., additional, Nannenberg, E. A., additional, Groeneweg, J. A., additional, Christiaans, I., additional, Van Gelder, I. C., additional, Hauer, R. N. W., additional, Van Den Berg, M. P., additional, Wilde, A. A. M., additional, and Van Tintelen, J. P., additional
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- 2013
- Full Text
- View/download PDF
28. Interaction of flucloxacillin and quinidine
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Comuth, W. J., primary, Comuth, J. A., additional, Hauer, R. N. W., additional, and Malingré, M. M., additional
- Published
- 2011
- Full Text
- View/download PDF
29. Poster Session 4
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Tada, H., primary, Yamasaki, H., additional, Sekiguchi, Y., additional, Igarashi, M., additional, Kuroki, K., additional, Machino, T., additional, Yoshida, K., additional, Aonuma, K., additional, Heinzel, F. R., additional, Forstner, H., additional, Lercher, P., additional, Bisping, E., additional, Rotman, B., additional, Fruhwald, F. M., additional, Pieske, B. M., additional, Dabrowski, R., additional, Kowalik, I., additional, Borowiec, A., additional, Smolis-Bak, E., additional, Trybuch, A., additional, Sosnowski, C., additional, Szwed, H., additional, Baturova, M. A., additional, Lindgren, A., additional, Shubik, Y. V., additional, Olsson, B., additional, Platonov, P. G., additional, Van Den Broek, K. C., additional, Denollet, J., additional, Widdershoven, J., additional, Kupper, N., additional, Allam, R., additional, Allam, R. A. G. A. B., additional, Galal, W. A. G. D. Y., additional, El-Damnhoury, H. A. Y. A. M., additional, Mortada, A. Y. M. A. N., additional, Jimenez-Candil, J., additional, Martin, A., additional, Hernandez, J., additional, Martin, F., additional, Gallego, M., additional, Martin-Luengo, C., additional, Quintanilla, J. G., additional, Moreno Planas, J., additional, Molina-Morua, R., additional, Archondo, T., additional, Garcia-Torrent, M. J., additional, Perez-Castellano, N., additional, Macaya, C., additional, Perez-Villacastin, J., additional, Saiz, J., additional, Tobon, C., additional, Rodriguez, J. F., additional, Hornero, F., additional, Ferrero, J. M., additional, Ito, K., additional, Date, T., additional, Kawai, M., additional, Hioki, M., additional, Narui, R., additional, Matsuo, S., additional, Yoshimura, M., additional, Yamane, T., additional, Tabatabaei, N., additional, Lin, G., additional, Powell, B. D., additional, Smairat, R., additional, Glockner, J. F., additional, Brady, P. A., additional, Fichtner, S., additional, Czudnochowsky, U., additional, Estner, H., additional, Reents, T., additional, Jilek, C., additional, Ammar, S., additional, Hessling, G., additional, Deisenhofer, I., additional, Shah, D. C., additional, Kautzner, J., additional, Saoudi, N., additional, Herrera, C., additional, Jais, P., additional, Hindricks, G., additional, Neuzil, P., additional, Kuck, K. H., additional, Wong, K. C. K., additional, Jones, M., additional, Qureshi, N., additional, Muthumala, A., additional, Betts, T. R., additional, Bashir, Y., additional, Rajappan, K., additional, Vogtmann, T., additional, Wagner, M., additional, Schurig, J., additional, Hein, P., additional, Hamm, B., additional, Baumann, G., additional, Lembcke, A., additional, Saad, B., additional, Slater, C., additional, Oliveira, L. A., additional, Elias, R., additional, Camiletti, A., additional, Moura, D., additional, Maldonado, P., additional, Camanho, L. E., additional, Bulava, A., additional, Hanis, J., additional, Sitek, D., additional, Novotny, A., additional, Chik, W. B., additional, Lim, T. W., additional, Choon, H. K., additional, See, V. A., additional, Mccall, R., additional, Thomas, L., additional, Ross, D. L., additional, Thomas, S. P., additional, Chen, J., additional, De Bortoli, A., additional, Rossvoll, O., additional, Hoff, P. I., additional, Solheim, E., additional, Sun, L. Z., additional, Schuster, P., additional, Ohm, O. J., additional, Ardashev, A. V., additional, Zhelyakov, E., additional, Rybachenko, M. S., additional, Konev, A. V., additional, Belenkov, Y. U. N., additional, Gunawardene, M., additional, Chun, K. R. J., additional, Schulte-Hahn, B., additional, Windhorst, V., additional, Kulikoglu, M., additional, Nowak, B., additional, Schmidt, B., additional, Albina, G. A., additional, Rivera, R. S., additional, Scazzuso, F., additional, Laino, R. L., additional, Giniger, G. A., additional, Arbelo, E., additional, Calvo, N., additional, Tamborero, D., additional, Andreu, D., additional, Borras, R., additional, Berruezo, A., additional, Brugada, J., additional, Mont, L., additional, Stefan, L., additional, Eisenberger, M., additional, Celentano, E., additional, Peytchev, P., additional, Bodea, O., additional, Geelen, P., additional, De Potter, T., additional, Oliveira, M. M., additional, Silva, N., additional, Cunha, P. S., additional, Feliciano, J., additional, Lousinha, A., additional, Toste, A., additional, Santos, S., additional, Ferreira, R. C., additional, Matsuda, H., additional, Harada, T., additional, Soejima, K., additional, Ishikawa, Y., additional, Mizukoshi, K., additional, Sasaki, T., additional, Mizuno, K., additional, Miyake, F., additional, Adragao, P. P., additional, Cavaco, D., additional, Miranda, R., additional, Santos, M., additional, Morgado, F., additional, Reis Santos, K., additional, Candeias, R., additional, Marcelino, S., additional, Zoppo, F., additional, Grandolino, G., additional, Zerbo, F., additional, Bertaglia, E., additional, Schlueter, S. M., additional, Grebe, O., additional, Vester, E. G., additional, Miracle Blanco, A. L., additional, Arenal Maiz, A., additional, Atienza Fernandez, F., additional, Datino Romaniega, T., additional, Gonzalez Torrecilla, E., additional, Eidelman, G., additional, Hernandez Hernandez, J., additional, Fernandez Aviles, F., additional, Fukumoto, K., additional, Takatsuki, S., additional, Kimura, T., additional, Nishiyama, N., additional, Aizawa, Y., additional, Sato, T., additional, Miyoshi, S., additional, Fukuda, K., additional, Richter, B., additional, Gwechenberger, M., additional, Socas, A., additional, Zorn, G., additional, Albinni, S., additional, Marx, M., additional, Wojta, J., additional, Goessinger, H., additional, Deneke, T., additional, Balta, O., additional, Paesler, M., additional, Buenz, K., additional, Anders, H., additional, Horlitz, M., additional, Muegge, A., additional, Shin, D.- I., additional, Natsuyama, K., additional, Yamaguchi, K. M., additional, Nishida, Y. N., additional, Kosiuk, J., additional, Bode, K., additional, Arya, A., additional, Piorkowski, C., additional, Gaspar, T., additional, Sommer, P., additional, Bollmann, A., additional, Wichterle, D., additional, Peichl, P., additional, Simek, J., additional, Havranek, S., additional, Bulkova, V., additional, Cihak, R., additional, Jurado Roman, A., additional, Salguero Bodes, R., additional, Lopez Gil, M., additional, Fontenla Cerezuela, A., additional, De Riva Silva, M., additional, Arribas Ynsaurriaga, F., additional, Fernandez Herranz, A. I., additional, De Dios Perez, S., additional, Revishvili, A. S., additional, Dishekov, M., additional, Tembotova, Z., additional, Barsamyan, S., additional, Vaccari, D., additional, Alvarenga, C., additional, Jesus, I., additional, Layher, J., additional, Takahashi, A., additional, Singh, N., additional, Siot, P., additional, Elkaim, J. P., additional, Savelieva, I., additional, Mcclelland, L., additional, Lovegrove, A., additional, Jones, S., additional, Camm, J., additional, Folino, A. F., additional, Breda, R., additional, Calzavara, P., additional, Comisso, J., additional, Borghetti, F., additional, Iliceto, S., additional, Buja, G., additional, Mlynarski, R., additional, Mlynarska, A., additional, Sosnowski, M., additional, Wilczek, J., additional, Mabo, P., additional, Carrault, G., additional, Bordachar, P., additional, Makdissi, A., additional, Duchemin, L., additional, Alonso, C., additional, Neri, G., additional, Masaro, G., additional, Vittadello, S., additional, Gardin, A., additional, Barbetta, A., additional, Di Gregorio, F., additional, Sciaraffia, E., additional, Ginks, M. R., additional, Gustafsson, J. S., additional, Hollmark, M. C., additional, Rinaldi, C. A., additional, Blomstrom Lundqvist, C., additional, Brusich, S., additional, Tomasic, D., additional, Ferek-Petric, B., additional, Mavric, Z., additional, Kutarski, A., additional, Malecka, B., additional, Kolodzinska, A., additional, Grabowski, M., additional, Dovellini, E. V., additional, Giurlani, L., additional, Cerisano, G., additional, Carrabba, N., additional, Valenti, R., additional, Antoniucci, D., additional, Opolski, G., additional, Tomassoni, G., additional, Baker, J., additional, Corbisiero, R., additional, Martin, D., additional, Niazi, I., additional, Sheppard, R., additional, Sperzel, J., additional, Gutleben, K., additional, Petru, J., additional, Sediva, L., additional, Skoda, J., additional, Mazzone, P., additional, Ciconte, G., additional, Vergara, P., additional, Marzi, A., additional, Paglino, G., additional, Sora, N., additional, Gulletta, S., additional, Della Bella, P., additional, Pietura, R., additional, Czajkowski, M., additional, Cabanelas, N., additional, Martins, V. P., additional, Alves, M., additional, Valente, F. X., additional, Marta, L., additional, Francisco, A., additional, Silva, R., additional, Ferreira Da Silva, G., additional, Huo, Y., additional, Holmqvist, F., additional, Carlson, J., additional, Wetzel, U., additional, Platonov, P., additional, Nof, E., additional, Abu Shama, R., additional, Kuperstein, R., additional, Feinberg, M. S., additional, Eldar, M., additional, Glikson, M., additional, Luria, D., additional, Kubus, P., additional, Materna, O., additional, Gebauer, R. A., additional, Matejka, T., additional, Gebauer, R., additional, Tlaskal, T., additional, Janousek, J., additional, Muessigbrodt, A., additional, Richter, S., additional, Stockburger, M., additional, Boveda, S., additional, Defaye, P., additional, Stancak Branislav, P., additional, Kaliska, G., additional, Rolando, M., additional, Moreno, J., additional, Ohlow, M.- A. G., additional, Lauer, B., additional, Buchter, B., additional, Schreiber, M., additional, Geller, J. C., additional, Val-Mejias, J. E., additional, Ouali, S., additional, Azzez, S., additional, Kacem, S., additional, Ben Salem, H., additional, Hammas, S., additional, Neffeti, E., additional, Remedi, F., additional, Boughzela, E., additional, Miyazaki, H., additional, Miyanaga, S., additional, Shibayama, K., additional, Tokuda, M., additional, Kudo, T., additional, Coppola, B., additional, Shehada, R. E. N., additional, Costandi, P., additional, Healey, J., additional, Hohnloser, S. H., additional, Gold, M. R., additional, Capucci, A., additional, Van Gelder, I. C., additional, Carlson, M., additional, Lau, C. P., additional, Connolly, S. J., additional, Bogaard, M. D., additional, Leenders, G. E., additional, Maskara, B., additional, Tuinenburg, A. E., additional, Loh, P., additional, Hauer, R. N., additional, Doevendans, P. A., additional, Meine, M., additional, Thibault, B., additional, Dubuc, M., additional, Karst, E., additional, Ryu, K., additional, Paiement, P., additional, Farazi, T., additional, Puetz, V., additional, Berndt, C., additional, Buchholz, J., additional, Dorszewski, A., additional, Mornos, C., additional, Cozma, D., additional, Ionac, A., additional, Petrescu, L., additional, Mornos, A., additional, Pescariu, S., additional, Benser, M., additional, Roscoe, G., additional, De Jong, S., additional, Roberts, G., additional, Boileau, P., additional, Rec, A., additional, Folman, C., additional, Morttada, A., additional, Abd El Kader, M., additional, Samir, R., additional, Roushdy, R., additional, Khaled, S., additional, Abo El Maaty, M., additional, Van Gelder, B., additional, Houthuizen, P., additional, Bracke, F. A., additional, Osca Asensi, J., additional, Tejada, D., additional, Sanchez, J. M., additional, Munoz, B., additional, Cano, O., additional, Rodriguez, M., additional, Sancho-Tello, M. J., additional, Olague, J., additional, Hou, W., additional, Rosenberg, S., additional, Koh, S., additional, Poore, J., additional, Snell, J., additional, Yang, M., additional, Nirav, D., additional, Bornzin, G., additional, Deering, T., additional, Dan, D., additional, Wickliffe, A. C., additional, Cazeau, S., additional, Karimzadeh, K., additional, Mukerji, S., additional, Loghin, C., additional, Kantharia, B., additional, Jones, M. A., additional, Lamba, J., additional, Simpson, C. S., additional, Redfearn, D. P., additional, Michael, K. A., additional, Fitzpatrick, M., additional, Baranchuk, A., additional, Heinke, M., additional, Ismer, B., additional, Kuehnert, H., additional, Surber, R., additional, Haltenberger, A. M., additional, Prochnau, D., additional, Figulla, H. 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Andersson, T., primary, Magnusson, A., additional, Bryngelsson, I.- L., additional, Frobert, O., additional, Henriksson, K. M., additional, Edvardsson, N., additional, Poci, D., additional, Polovina, M., additional, Potpara, T., additional, Licina, M., additional, Mujovic, N., additional, Kocijancic, A., additional, Simic, D., additional, Ostojic, M. C., additional, Providencia, R. A., additional, Botelho, A., additional, Trigo, J., additional, Nascimento, J., additional, Quintal, N., additional, Mota, P., additional, Leitao-Marques, A. M., additional, Bosch, R. F., additional, Kirch, W., additional, Rosin, L., additional, Willich, S. N., additional, Pittrow, D., additional, Bonnemeier, H., additional, Valenza, M. C., additional, Martin, L., additional, Munoz Casaubon, T., additional, Valenza, G., additional, Botella, M., additional, Serrano, M., additional, Valenza, B., additional, Cabrera, I., additional, Anderson, K., additional, Benzaquen, B. S., additional, Koziolova, N., additional, Nikonova, J., additional, Shilova, Y., additional, Scherr, D., additional, Narayan, S., additional, Wright, M., additional, Krummen, D., additional, Jadidi, A., additional, Jais, P., additional, Haissaguerre, M., additional, Hocini, M., additional, Hunter, R., additional, Liu, Y., additional, Lu, Y., additional, Wang, W., additional, Schilling, R. J., additional, Bernstein, S., additional, Wong, B., additional, Rooke, R., additional, Vasquez, C., additional, Shah, R., additional, Rosenberg, S., additional, Chinitz, L., additional, Morley, G., additional, Bashir Choudhary, M., additional, Holmqvist, F., additional, Carlson, J., additional, Nilsson, H.- J., additional, Platonov, P. G., additional, Jadidi, A. S., additional, Cochet, H., additional, Miyazaki, S., additional, Shah, A. J., additional, Marrouche, N., additional, Calvo, N., additional, Nadal, M., additional, Andreu, D., additional, Tamborero, D., additional, Diaz, F. 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M., additional, Daba, L., additional, Liebrecht, K., additional, Piwowarska, W., additional, Toquero Ramos, J., additional, Perez Pereira, E., additional, Mitroi, C., additional, Castro Urda, V., additional, Fernandez Villanueva, J. M., additional, Corona Figueroa, A., additional, Hernandez Reina, L., additional, Fernandez Lozano, I., additional, Bartoletti, A., additional, Bocconcelli, P., additional, Giuli, S., additional, Massa, R., additional, Svetlich, C., additional, Tarsi, G., additional, Tronconi, F., additional, Vitale, E., additional, Stryjewski, P., additional, Wegrzynowska, M., additional, Lousinha, A., additional, Labandeiro, J., additional, Antunes, E., additional, Silva, S., additional, Alves, S., additional, Timoteo, A., additional, Oliveira, M., additional, Cruz Ferreira, R., additional, and Jedrzejczyk-Spaho, J., additional
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31. Poster Session 1
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Deshmukh, A., primary, Sharma, S. S., additional, Gobal, F. G., additional, Singla, S. S., additional, Hebbar, P. H., additional, Paydak, H. P., additional, Igarashi, M., additional, Tada, H., additional, Sekiguchi, Y., additional, Yamasaki, H., additional, Kuroki, K., additional, Machino, T., additional, Yoshida, K., additional, Aonuma, K., additional, Shavadia, J., additional, Otieno, H., additional, Yonga, G., additional, Jinah, A., additional, Qvist, J. F., additional, Soerensen, P. H., additional, Dixen, U., additional, Ramirez-Marrero, M. A., additional, Perez-Villardon, B., additional, Gaitan-Roman, D., additional, Jimenez-Navarro, M., additional, Delgado-Prieto, J. L., additional, De Teresa-Galvan, E., additional, De Mora-Martin, M., additional, Deshmukh, A., additional, Hebbar, P. B., additional, Wei, W. X., additional, Bardari, S., additional, Zecchin, M., additional, Salame', R., additional, Vitali Serdoz, L., additional, Di Lenarda, A., additional, Guerrini, N., additional, Barbati, G., additional, Sinagra, G., additional, Hanazawa, K., additional, Kaitani, K., additional, Nakagawa, Y., additional, Lenaerts, I., additional, Driesen, R., additional, Hermida, N., additional, Heidbuchel, H., additional, Janssens, S., additional, Balligand, J. L., additional, Sipido, K. R., additional, Willems, R., additional, Sehra, R., additional, Krummen, D., additional, Briggs, C., additional, Narayan, S., additional, Tanaka, Y., additional, Hirao, K., additional, Nakamura, T., additional, Inaba, O., additional, Yagishita, A., additional, Higuchi, K., additional, Hachiya, H., additional, Isobe, M., additional, Kallergis, E., additional, Kanoupakis, E. M., additional, Mavrakis, H. E., additional, Goudis, C. A., additional, Maliaraki, N. E., additional, Vardas, P. 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H., additional, Koelsch, S., additional, Maisch, B., additional, Bolzani, V., additional, Costandi, P., additional, Shehada, R. E., additional, Butala, N., additional, Coppola, B., additional, Taborsky, M., additional, Heinc, P., additional, Fedorco, M., additional, Doupal, V., additional, Di Cori, A., additional, Zucchelli, G., additional, Soldati, E., additional, Segreti, L., additional, De Lucia, R., additional, Viani, S., additional, Paperini, L., additional, Bongiorni, M. G., additional, Gutleben, K. J., additional, Kranig, W., additional, Barr, C., additional, Morgenstern, M. M., additional, Simon, M., additional, Dalal, Y. H., additional, Landolina, M., additional, Pierantozzi, A., additional, Agricola, T., additional, Lunati, M., additional, Pisano', E., additional, Lonardi, G., additional, Bardelli, G., additional, Zucchi, G., additional, Thibault, B., additional, Dubuc, M., additional, Karst, E., additional, Ryu, K., additional, Paiement, P., additional, Carlson, M. D., additional, Farazi, T., additional, Alhous, H., additional, Mont, L., additional, Porres, J. M., additional, Alzueta, J., additional, Beiras, X., additional, Fernandez-Lozano, I., additional, Macias, A., additional, Ruiz, R., additional, Brugada, J., additional, Viani, S. M., additional, Seifert, M., additional, Schau, T., additional, Moeller, V., additional, Meyhoefer, J., additional, Butter, C., additional, Ganiere, V., additional, Niculescu, V., additional, Domenichini, G., additional, Stettler, C., additional, Defaye, P., additional, Burri, H., additional, Stockburger, M., additional, De Teresa, E., additional, Lamas, G., additional, Desaga, M., additional, Koenig, C., additional, Cobo, E., additional, Navarro, X., additional, Wiegand, U., additional, Blich, M., additional, Carasso, S., additional, Suleiman, M., additional, Marai, I., additional, Gepstein, L., additional, Boulos, M., additional, Sasov, M., additional, Liska, B., additional, Margitfalvi, P., additional, Malacky, T., additional, Svetlosak, M., additional, Goncalvesova, E., additional, Hatala, R., additional, Takaya, Y., additional, Noda, T., additional, Yamada, Y., additional, Okamura, H., additional, Satomi, K., additional, Shimizu, W., additional, Aihara, N., additional, Kamakura, S., additional, Proclemer, A., additional, Boveda, S., additional, Oswald, H., additional, Scipione, P., additional, Da Costa, A., additional, Brzozowski, W., additional, Tomaszewski, A., additional, Wysokinski, A., additional, Arbelo, E., additional, Tamborero, D., additional, Vidal, B., additional, Tolosana, J. M., additional, Sitges, M., additional, Matas, M., additional, Botto, G. L., additional, Dicandia, C. D., additional, Mantica, M., additional, La Rosa, C., additional, D' Onofrio, A., additional, Molon, G., additional, Raciti, G., additional, Verlato, R., additional, Foley, P. W. X., additional, Chalil, S., additional, Ratib, K., additional, Smith, R. E. A., additional, Printzen, F., additional, Auricchio, A., additional, Leyva, F., additional, Abu Sham'a, R., additional, Buber, J., additional, Luria, D., additional, Kuperstein, R., additional, Feinberg, M., additional, Granit, H., additional, Eldar, M., additional, Glikson, M., additional, Vondrak, K., additional, Nof, E., additional, Lipchenca, I., additional, Vatasescu, R.- G., additional, Iorgulescu, C., additional, Caldararu, C., additional, Vasile, A., additional, Bogdan, S., additional, Constantinescu, D., additional, Dorobantu, M., additional, Sakaguchi, H., additional, Miyazaki, A., additional, Yamamoto, T., additional, Fujimoto, K., additional, Ono, S., additional, Ohuchi, H., additional, Martinelli, M., additional, Martins, S., additional, Molina, R., additional, Siqueira, S., additional, Nishioka, S. A. D., additional, Peixoto, G. L., additional, Alkmim-Teixeira, R., additional, Costa, R., additional, Meine, M. M., additional, Tuinenburg, A. E., additional, Doevendans, P. A., additional, Denollet, J., additional, Goscinska-Bis, K., additional, Zupan, I., additional, Van Der, H., additional, Anselme, F., additional, Hartog, H., additional, Block, M., additional, Borri, A., additional, Padeletti, L., additional, Toniolo, M., additional, Zanotto, G., additional, Rossi, A., additional, Raytcheva, E., additional, Tomasi, L., additional, Vassanelli, C., additional, Fernandez Lozano, I., additional, Mitroi, C., additional, Toquero Ramos, J., additional, Castro Urda, V., additional, Monivas Palomero, V., additional, Corona Figueroa, A., additional, Ruiz Bautista, L., additional, Alonso Pulpon, L., additional, Jadidi, A. S., additional, Sacher, F., additional, Shah, A. S., additional, Scherr, D., additional, Derval, N., additional, Hocini, M., additional, Haissaguerre, M., additional, Castrejon Castrejon, S., additional, Largo-Aramburu, C., additional, Sachar, J., additional, Gang, E., additional, Estrada, A., additional, Doiny, D., additional, De Miguel, E., additional, Merino, J. L., additional, Trevisi, N., additional, Ricco, A., additional, Petracca, F., additional, Baratto, F., additional, Bisceglie, A., additional, Maccabelli, G., additional, El-Damaty, A., additional, Sapp, J., additional, Warren, J., additional, Macinnis, P., additional, Horacek, M., additional, Dinov, B., additional, Schoenbauer, R., additional, Braunschweig, F., additional, Arya, A., additional, Andreu, D., additional, Berruezo, A., additional, Ortiz, J. T., additional, Silva, E., additional, De Caralt, T. M., additional, Fernandez-Armenta, J., additional, Perez-Silva, A., additional, Ortega, M., additional, Lopez-Sendon, J. 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M., additional, Kolb, C., additional, Pytkowski, M., additional, Maciag, A., additional, Farkowski, M., additional, Jankowska, A., additional, Kowalik, I., additional, Kraska, A., additional, Szwed, H., additional, Maury, P., additional, Duparc, A., additional, Mondoly, P., additional, Rollin, A., additional, Pap, R., additional, Kohari, M., additional, Bencsik, G., additional, Makai, A., additional, Saghy, L., additional, Forster, T., additional, Ebrille, E., additional, Scaglione, M., additional, Raimondo, C., additional, Caponi, D., additional, Di Donna, P., additional, Blandino, A., additional, Delcre, S. D. L., additional, Gaita, F., additional, Roca Luque, I., additional, Dos, L. D. S., additional, Rivas, N. R. G., additional, Pijuan, A. P. D., additional, Perez, J., additional, Casaldaliga, J., additional, Garcia-Dorado, D. G. D., additional, Moya, A. M. M., additional, Sato, H., additional, Yagi, T., additional, Yambe, T., additional, Streitner, F., additional, Dietrich, C., additional, Mahl, E., additional, Schoene, N., additional, Veltmann, C., additional, Borggrefe, M., additional, Kuschyk, J., additional, Sadarmin, P. P., additional, Wong, K. C. K., additional, Rajappan, K., additional, Bashir, Y., additional, Betts, T. R., additional, Leclercq, C., additional, Martins, R., additional, Daubert, J. C., additional, Mabo, P., additional, Koide, M., additional, Hamano, G., additional, Taniguchi, T., additional, Yamato, M., additional, Sasaki, N., additional, Hirooka, K., additional, Ikeda, Y., additional, Yasumura, Y., additional, Dichtl, W., additional, Wolber, T., additional, Paoli, U., additional, Bruellmann, S., additional, Berger, T., additional, Stuehlinger, M., additional, Duru, F., additional, Hintringer, F., additional, Kanoupakis, E., additional, Mavrakis, H., additional, Koutalas, E., additional, Saloustros, I., additional, Goudis, C., additional, Chlouverakis, G., additional, Vardas, P., additional, Herre, J. M., additional, Saeed, M., additional, Saberi, L., additional, Neuman, S., additional, Yamaji, K., additional, Iwabuchi, M., additional, Baranchuk, A., additional, Femenia, F., additional, Miranda Hermosilla, R., additional, Lopez Diez, J. C., additional, Serra, J. L., additional, Valentino, M., additional, Retyk, E., additional, Galizio, N., additional, Kwasniewski, W., additional, Filipecki, A., additional, Orszulak, W., additional, Urbanczyk-Swic, D., additional, Trusz - Gluza, M., additional, Piot, O., additional, Degand, B., additional, Donofrio, A., additional, Scanu, P., additional, Quesada, A., additional, Kloppe, A., additional, Mijic, D., additional, Bogossian, H., additional, Zarse, M., additional, Lemke, B., additional, Tyler, J., additional, Comfort, G., additional, Deering, T. F., additional, Epstein, A. E., additional, Greenberg, S. M. G., additional, Goldman, D. S., additional, Rhude, J., additional, Majewski, J. P., additional, Lelakowski, J., additional, Tomala, I., additional, Santos, C. M., additional, Miranda, R. S., additional, Sousa, P. J., additional, Cavaco, D. M., additional, Adragao, P. P., additional, Knops, R. E., additional, Wilde, A. A., additional, Belhameche, M., additional, Hermida, J. S., additional, Dovellini, E., additional, Frohlig, G., additional, Siot, P., additional, Duray, G. Z., additional, Israel, C. W., additional, Brachmann, J., additional, Seidl, K. H., additional, Foresti, M., additional, Birkenhauer, F., additional, Hohnloser, S. H., additional, Ferreira, C., additional, Mateus, P., additional, Ribeiro, H., additional, Carvalho, S., additional, Ferreira, A., additional, Moreira, J., additional, Kadro, W., additional, Rahim, H., additional, Turkmani, M., additional, Abu Lebdeh, M., additional, Altabban, A., additional, Cerrato, N., additional, Rivera, S., additional, Scazzuso, F., additional, Albina, G., additional, Klein, A., additional, Laino, R., additional, Sammartino, V., additional, Giniger, A., additional, Kvantaliani, T., additional, Akhvlediani, M., additional, Namdar, M., additional, Steffel, J., additional, Jetzer, S., additional, Bayrak, F., additional, Chierchia, G. B., additional, Jenni, R., additional, Brugada, P., additional, Bakos, Z., additional, Medvedev M, M. M., additional, Jonas Carlsson, J. C., additional, Fredrik Holmqvist, F. H., additional, Pyotr Platonov, P. P., additional, Nurbaev, T., additional, Pirnazarov, M., additional, Nikishin, A., additional, Aagaard, P., additional, Sahlen, A., additional, Bergfeldt, L., additional, Simeonidou, E., additional, Kastellanos, S., additional, Varounis, C., additional, Michalakeas, C., additional, Koniari, C., additional, Nikolopoulou, A., additional, Anastasiou-Nana, M., additional, Furukawa, Y., additional, Yamada, T., additional, Morita, T., additional, Tanaka, K., additional, Iwasaki, Y., additional, Kawasaki, M., additional, Kuramoto, Y., additional, Fukunami, M., additional, Blanche, C., additional, Tran, N., additional, Rigamonti, F., additional, Zimmermann, M., additional, Okisheva, E., additional, Tsaregorodtsev, D., additional, Sulimov, V., additional, Novikova, D., additional, Popkova, T., additional, Udachkina, E., additional, Korsakova, Y., additional, Volkov, A., additional, Novikov, A., additional, Alexandrova, E., additional, Nasonov, E., additional, Arsenos, P., additional, Gatzoulis, K., additional, Manis, G., additional, Dilaveris, P., additional, Gialernios, T., additional, Kartsagoulis, E., additional, Asimakopoulos, S., additional, Stefanadis, C., additional, Marocolo, M., additional, Barbosa Neto, O., additional, Carvalho, A. C., additional, Marques Neto, S. R., additional, Mota, G. R., additional, Barbosa, P. R. B., additional, Fernandez-Fernandez, A., additional, Manzano Fernandez, S., additional, Pastor-Perez, F. J., additional, Barquero-Perez, O., additional, Goya-Esteban, R., additional, Salar, M., additional, Rojo-Alvarez, J. L., additional, Garcia-Alberola, A., additional, Takigawa, M., additional, Kawamura, M., additional, Aiba, T., additional, Sakaguchi, T., additional, Itoh, H., additional, Horie, M., additional, Igarashi, T., additional, Negishi, J., additional, Toyota, N., additional, Yamada, O., additional, Papavasileiou, M., additional, Cabrera Bueno, F., additional, Molina Mora, M. J., additional, Alzueta Rodriguez, J., additional, Barrera Cordero, A., additional, De Teresa Galvan, E., additional, Revishvili, A. S., additional, Dzhordzhikiya, T., additional, Sopov, O., additional, Simonyan, G., additional, Lyadzhina, O., additional, Fetisova, E., additional, Kalinin, V., additional, Balt, J. C., additional, Steggerda, R. C., additional, Boersma, L. V. A., additional, Wijffels, M. C. E. F., additional, Wever, E. F. D., additional, Ten Berg, J. M., additional, Ricci, R. P., additional, Morichelli, L., additional, D'onofrio, A., additional, Vaccari, D., additional, Calo', L., additional, Buja, G., additional, Rovai, N., additional, Gargaro, A., additional, Sperzel, J., additional, Speca, G., additional, Santini, L., additional, Haarbo, J., additional, Dubin, K., additional, Carlson, M., additional, Garcia Quintana, A., additional, Mendoza-Lemes, H., additional, Garcia Perez, L., additional, Led Ramos, S., additional, Caballero Dorta, E., additional, Matinez De Espronceda, M., additional, Piro Mastracchio, V., additional, Serrano Arriezu, L., additional, Sciarra, L., additional, Marziali, M., additional, Marras, E., additional, Rebecchi, M., additional, Allocca, G., additional, Lioy, E., additional, Delise, P., additional, Santobuono, V. E., additional, Iacoviello, M., additional, Nacci, F., additional, Luzzi, G., additional, Puzzovivo, A., additional, Memeo, M., additional, Quadrini, F., additional, Favale, S., additional, Trucco, M. E., additional, Arce, M., additional, Palazzolo, J., additional, Uribe, W., additional, Maggi, R., additional, Furukawa, T., additional, Croci, F., additional, Solano, A., additional, Brignole, M., additional, Lebreiro, A., additional, Sousa, A., additional, Correia, A. S., additional, Lourenco, P., additional, Oliveira, S., additional, Paiva, M., additional, Freitas, J., additional, Maciel, M. J., additional, Linker, N., additional, Rieger, G., additional, Garutti, C., additional, Edvardsson, N., additional, Salguero Bodes, R., additional, De Riva Silva, M., additional, Fontenla Cerezuela, A., additional, Lopez Gil, M., additional, Mejia Martinez, E., additional, Jurado Roman, A., additional, Garcia Alvarez, S., additional, Arribas Ynsaurriaga, F., additional, Petix, N. R., additional, Del Rosso, A., additional, Guarnaccia, V., additional, Zipoli, A., additional, Rabajoli, F., additional, Foglia Manzillo, G., additional, Tolardo, C., additional, Checchinato, C., additional, Chiaravallotti, S., additional, Santarone, M., additional, Spinnler, M. T., additional, Podoleanu, C., additional, Frigy, A., additional, Dobreanu, D., additional, Ginghina, C., additional, and Carasca, E., additional
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- 2011
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32. Manifest disease, risk factors for sudden cardiac death, and cardiac events in a large nationwide cohort of predictively tested hypertrophic cardiomyopathy mutation carriers: determining the best cardiological screening strategy
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Christiaans, I., primary, Birnie, E., additional, Bonsel, G. J., additional, Mannens, M. M. A. M., additional, Michels, M., additional, Majoor-Krakauer, D., additional, Dooijes, D., additional, van Tintelen, J. P., additional, van den Berg, M. P., additional, Volders, P. G. A., additional, Arens, Y. H., additional, van den Wijngaard, A., additional, Atsma, D. E., additional, Helderman-van den Enden, A. T. J. M., additional, Houweling, A. C., additional, de Boer, K., additional, van der Smagt, J. J., additional, Hauer, R. N. W., additional, Marcelis, C. L. M., additional, Timmermans, J., additional, van Langen, I. M., additional, and Wilde, A. A. M., additional
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- 2011
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33. Brugada syndrome
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Wilde, A. A. M., Remme, C. A., Derksen, R., Wever, E. F. D., Hauer, R. N. W., and Cardiology
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Cardiology and Cardiovascular Medicine - Published
- 2002
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34. Can optimization of pacing settings compensate for a non-optimal left ventricular pacing site?
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Bogaard, M. D., primary, Doevendans, P. A., additional, Leenders, G. E., additional, Loh, P., additional, Hauer, R. N. W., additional, van Wessel, H., additional, and Meine, M., additional
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- 2010
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35. Ventriculaire ritmestoornissen.
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Hauer, R. N. W.
- Abstract
Copyright of Cardiologie is the property of Springer Nature / Books and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2008
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36. Unexplained cardiac arrest, The need for a prospective registry
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PRIORI, S. G., primary, BORGGREFE, M., additional, CAMM, A. J., additional, HAUER, R. N. W., additional, KLEIN, H., additional, KUCK, K.-H., additional, SCHWARTZ, P. J., additional, TOUBOUL, P., additional, and WELLENS, H. J. J., additional
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- 1992
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37. Haplotype sharing test maps genes for familial cardiomyopathies.
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van der Zwaag, P. A., van Tintelen, J. P., Gerbens, F., Jongbloed, J. D. H., Boven, L. G., van der Smagt, J. J., van der Roest, W. P., van Langen, I. M., Bikker, H., Hauer, R. N. W., van den Berg, M. P., Hofstra, R. M. W., and te Meerman, G. J.
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CARDIOMYOPATHIES ,GENES ,GENETIC mutation ,MEIOSIS ,CHROMOSOMES - Abstract
van der Zwaag PA, van Tintelen JP, Gerbens F, Jongbloed JDH, Boven LG, van der Smagt JJ, van der Roest WP, van Langen IM, Bikker H, Hauer RNW, van den Berg MP, Hofstra RMW, te Meerman GJ. Haplotype sharing test maps genes for familial cardiomyopathies. Identifying a mutation in a heterogeneous disease such as inherited cardiomyopathy is a challenge because classical methods, like linkage analysis, can often not be applied as there are too few meioses between affected individuals. However, if affected individuals share the same causal mutation, they will also share a genomic region surrounding it. High-density genotyping arrays are able to identify such regions shared among affected individuals. We hypothesize that the longest shared haplotype is most likely to contain the disease-causing mutation. We applied this method to two pedigrees: one with arrhythmogenic right ventricular cardiomyopathy (ARVC) and one with dilated cardiomyopathy (DCM), using high-density genome-wide SNP arrays. In the ARVC pedigree, the largest haplotype was on chromosome 12 and contained a causative PKP2 mutation. In the DCM pedigree, a causative MYH7 mutation was present on a large shared haplotype on chromosome 14. We calculated that a pedigree containing at least seven meioses has a high chance of correctly detecting the mutation-containing haplotype as the largest. Our data show that haplotype sharing analysis can assist in identifying causative genes in families with low penetrance Mendelian diseases, in which standard tools cannot be used due to lack of sufficient pedigree information. [ABSTRACT FROM AUTHOR]
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- 2011
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38. Implantable cardioverter defibrillator recipients: quality of life in recipients with and without ICD shock delivery.
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Kamphuis, H. C. M., de Leeuw, J. R. J., Derksen, R., Hauer, R. N. W., and Winnubst, J. A. M.
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Aims The experiences of patients who received shocks from their implantable cardioverter defibrillator (ICD) and how these events affect their overall adjustment are poorly understood. Our goal was to evaluate quality of life and psychological well-being, and the prevalence of, and changes in, depression and anxiety of patients who did or did not experience defibrillatory shocks in the first 12 months after ICD implantation. In total 167 patients were monitored after discharge. Four self-administered questionnaires were used. The first assessment took place before ICD implantation, the remaining three at 1, 6 and 12 months after discharge. Results We classified patients into three shock groups and one no shock group. A small group of ICD recipients (26%) received ICD shock delivery, usually during the last 6 months of the study. Borderline significant differences were found within the groups over time regarding physical role limitations (P<0.051). Those who experienced shocks throughout the year (group 1) felt more limited in their daily activities due to physical or mental problems. All groups reported an improvement in their health (P<0.001). Overall quality of life did not change significantly after 6 months. Anxiety and depression did not change significantly over time. In total 22–66% of patients reported clinically significant depressive symptoms throughout the first year, and 31–83% clinically significant symptoms of anxiety. ICD recipients who had experienced a shock were significantly more anxious one year postdischarge than those who had not received a shock. Conclusions Overall quality of life and psychological well-being did not change in ICD recipients, irrespective of whether they experienced defibrillatory shocks. The high prevalence of depression and anxiety can be interpreted as a response to the perceived physical and mental problems regarding daily activities. Our data indicate that patients who have experienced an ICD shock do not adapt well to living with an ICD, they are more anxious than ICD recipients who received no shocks. However, the anticipation of having another shock after experiencing one is less stressful than that of the first shock. We conclude that the lasting psychological distress will not dissipate spontaneously or naturally and that psychosocial interventions may be warranted. [ABSTRACT FROM PUBLISHER]
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- 2003
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39. Indications for implantable cardioverter defibrillator (ICD) therapy.
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Hauer, R. N. W., Aliot, E., Block, M., Capucci, A., Lüderitz, B., Santini, M., and Vardas, P. E.
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- 2001
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40. Recommendations for qualification of centres implanting and following defibrillators.
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Lévy, S., Hauer, R. N. W., Raviele, A., Daubert, J.-C., Campbell, R. W. F., and Breithardt, G.
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- 1996
41. Presymptomatisch onderzoek na plotselinge hartdood in de familie
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Wilde, A. A. M., Irene van Langen, Tintelen, J. P., Hauer, R. N. W., Reproductive Origins of Adult Health and Disease, Cardiovasculair Centrum, and Health Psychology Research
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electrocardiography ,disease association ,chemoprophylaxis ,review ,ST segment elevation ,health care cost ,sudden death ,beta adrenergic receptor blocking agent ,heart right bundle branch block ,genetic screening ,heart disease ,heart pacing ,defibrillation ,clinical feature ,autosomal dominant inheritance ,hypertrophic obstructive cardiomyopathy ,long QT syndrome ,heart ventricle tachycardia ,human ,cardiomyopathy ,familial disease - Abstract
Sudden cardiac death without ischaemic heart disease may be due to a hereditary heart disease with an autosomal dominant heredity. The occurrence, if any, of sudden death in such a family is a main indicator for the risk of sudden cardiac death in other family members. Cardiological and/or genetic investigation may reveal a hereditary disease in relatives without symptoms. Of some of these pathological conditions, the corresponding chromosomal localizations and sometimes the gene mutations have been identified. The psychic burden of family investigation and the socio-economic consequences (insurances, occupation, family relationships) are potentially heavy. Prophylactic treatment of asymptomatic persons in whom a gene mutation is established may comprise advice about lifestyle (e.g. avoidance of peak exercise in patients with hypertrophic cardiomyopathy), medication (e.g. beta-receptor blockers in patients with a long QT interval) or implantation of a pacemaker or internal defibrillator (e.g. in asymptomatic persons with the Brugada syndrome, a form of right bundle branch block). Presymptomatic investigation must be performed multidisciplinary.
42. Ventricular repolarization and the long QT syndrome
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Conrath, C. E., Hauer, R. N. W., Opthof, T., and Cardiology
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- 2005
43. Recurrent and founder mutations in the Netherlands : Plakophilin-2 p.Arg79X mutation causing arrhythmogenic right ventricular cardiomyopathy/dysplasia.
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van der Zwaag PA, Cox MG, van der Werf C, Wiesfeld AC, Jongbloed JD, Dooijes D, Bikker H, Jongbloed R, Suurmeijer AJ, van den Berg MP, Hofstra RM, Hauer RN, Wilde AA, and van Tintelen JP
- Abstract
Background: Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is an inherited cardiac disease with reduced penetrance and a highly variable expression. Mutations in the gene encoding the plakophilin-2 gene (PKP2) are detected in about 50% of ARVC/D patients. The p.Arg79X mutation in PKP2 has been identified in Europe and North America and has been functionally characterised. We evaluated the prevalence of the p.Arg79X mutation in PKP2 in the Dutch population., Methods: Twelve index patients and 41 family members were evaluated in three university hospitals in the Netherlands. The diagnosis of ARVC/D was established according to the recently revised Task Force Criteria. Segregation of the p.Arg79X mutation was studied and haplotypes were reconstructed to determine whether the p.Arg79X mutation was a recurrent or a founder mutation., Results: The p.Arg79X mutation in PKP2 was identified in 12 index patients. Haplotype analysis revealed a shared haplotype among Dutch p.Arg79X mutation carriers, indicating a common founder. Six index patients (50%) had a first- or second-degree relative who had died of sudden cardiac death below 40 years of age. At age 60, only 60% of the mutation carriers had experienced any symptoms. There was no significant difference in symptom-free survival and event-free survival between men and women., Conclusion: We have identified the largest series of patients with the same desmosome gene mutation in ARVC/D reported to date. This p.Arg79X mutation in PKP2 is a founder mutation in the Dutch population. The phenotypes of PKP2 p.Arg79X mutation carriers illustrate the clinical variability and reduced penetrance often seen in ARVC/D. (Neth Heart J 2010;18:583-91.).
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- 2010
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44. Conduction reserve and arrhythmias.
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Stein M, Boulaksil M, Engelen MA, van Veen TA, Hauer RN, de Bakker JM, and van Rijen HV
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- 2006
45. Recommendations and cardiological evaluation of athletes with arrhythmias: Part 2.
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Hoogsteen J, Bennekers JH, van der Wall EE, van Hemel NM, Wilde AA, Crijns HJ, Gorgels AP, Smeets JL, Hauer RN, Jordaens JL, and Schalij MJ
- Abstract
Confronted with a competitive or recreational athlete, the physician has to discriminate between benign, paraphysiological and pathological arrhythmias. Benign arrhythmias do not represent a risk for SCD, nor do they induce haemodynamic consequences during athletic activities. These arrhythmias are not markers for heart disease. Paraphysiological arrhythmias are related to athletic performance. Long periods of endurance training induce changes in rhythm, conduction and repolarisation. These changes are fully reversible and disappear when the sport is terminated. Pathological arrhythmias have haemodynamic consequences and express disease, such as sick sinus syndrome, cardiomyopathy or inverse consequences of physical training. Arrhythmias can be classified as bradyarrhythmias and tachyarrhythmias. Conduction disorders can be seen in fast as well as in slow arrhythmias.
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- 2004
46. Recommendations and cardiological evaluation of athletes with arrhythmias: Part 1.
- Author
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Hoogsteen J, Bennekers JH, van der Wall EE, van Hemel NM, Wilde AA, Crijns HJ, Gorgels AP, Smeets JL, Hauer RN, Jordaens JL, and Schalij MJ
- Abstract
Besides the consensus meeting in Amersfoort in 1988 and the Bethesda conference in 1994 recommendations are not available in the Netherlands for screening and evaluation of athletes with cardiac arrhythmias. Guidelines for competitive athletes with cardiac arrhythmias in the United States and Italy were published in 2000. In 1998 Estes et al. published the most important opinions on sudden cardiac death, screening and evaluation of athletes and arrhythmias. This study addresses the physiological and morphological consequences of athletic training, cardiac pathology and risk stratification for sudden cardiac death. Recommendations for competitive athletes with cardiovascular abnormalities, arrhythmias and proposals for specific protocols are given.
- Published
- 2004
47. Implantable cardioverter defibrillator recipients: quality of life in recipients with and without ICD shock delivery: a prospective study.
- Author
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Kamphuis HC, de Leeuw JR, Derksen R, Hauer RN, and Winnubst JA
- Subjects
- Activities of Daily Living, Case-Control Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Socioeconomic Factors, Adaptation, Psychological, Anxiety epidemiology, Arrhythmias, Cardiac psychology, Arrhythmias, Cardiac therapy, Defibrillators, Implantable psychology, Depression epidemiology, Quality of Life
- Abstract
Aims: The experiences of patients who received shocks from their implantable cardioverter defibrillator (ICD) and how these events affect their overall adjustment are poorly understood. Our goal was to evaluate quality of life and psychological well-being, and the prevalence of, and changes in, depression and anxiety of patients who did or did not experience defibrillatory shocks in the first 12 months after ICD implantation. In total 167 patients were monitored after discharge. Four self-administered questionnaires were used. The first assessment took place before ICD implantation, the remaining three at 1, 6 and 12 months after discharge., Results: We classified patients into three shock groups and one no shock group. A small group of ICD recipients (26%) received ICD shock delivery, usually during the last 6 months of the study. Borderline significant differences were found within the groups over time regarding physical role limitations (P < 0.051). Those who experienced shocks throughout the year (group 1) felt more limited in their daily activities due to physical or mental problems. All groups health (P < 0.001). Overall quality of life did not change significantly after 6 months. Anxiety and depression did not change significantly over time. In total 22-66% of patients reported clinically significant depressive symptoms throughout the first year, and 31-83% clinically significant symptoms of anxiety. ICD recipients who had experienced a shock were significantly more anxious one-year postdischarge than those who had not received a shock., Conclusions: Overall quality of life and psychological well-being did not change in ICD recipients, irrespective of whether they experienced defibrillatory shocks. The high prevalence of depression and anxiety can be interpreted as a response to the perceived physical and mental problems regarding daily activities. Our data indicate that patients who have experienced an ICD shock do not adapt well to living with an ICD, they are more anxious than ICD recipients who received no shocks. However, the anticipation of having another shock after experiencing one is less stressful than that of the first shock. We conclude that the lasting psychological distress will not dissipate spontaneously or naturally and that psychosocial interventions may be warranted.
- Published
- 2003
- Full Text
- View/download PDF
48. Proposed diagnostic criteria for the Brugada syndrome.
- Author
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Wilde AA, Antzelevitch C, Borggrefe M, Brugada J, Brugada R, Brugada P, Corrado D, Hauer RN, Kass RS, Nademanee K, Priori SG, and Towbin JA
- Subjects
- Bundle-Branch Block genetics, Diagnosis, Differential, Electrocardiography drug effects, Electrocardiography methods, Humans, Mutation genetics, Bundle-Branch Block diagnosis
- Published
- 2002
- Full Text
- View/download PDF
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