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357 results on '"Hatzitolios, A I"'

2. Assessing Staff’s and Stroke Patients’ Experiences in 8 Hospitals in Greece: Results from a Prospective Multi-Center Study (“SUN4Patients”)

Author

Galanis, Petros, primary, Konstantakopoulou, Olympia, additional, Karagkouni, Iliana, additional, Gallos, Paris, additional, Tsampalas, Evangelos, additional, Lypiridou, Maria, additional, Gamvroula, Anastasia, additional, Mavraganis, Georgios, additional, Manios, Efstathios, additional, Ntaios, George, additional, Karagkiozi, Efstathia, additional, Milionis, Haralampos, additional, Evangelou, Chara, additional, Tountopoulou, Argyro, additional, Kouzi, Ioanna, additional, Vassilopoulou, Sofia, additional, Protogerou, Athanasios, additional, Samara, Stamatina, additional, Karapiperi, Asteria, additional, Savopoulos, Christos, additional, Hatzitolios, Apostolos I., additional, Myrou, Athina, additional, Kalliontzakis, Ioannis, additional, Kouridaki, Aspasia, additional, Papastefanatos, Stefanos, additional, Papastefanatos, George, additional, Vemmos, Kostas, additional, Sourtzi, Panayiota, additional, Bellali, Thalia, additional, Korompoki, Eleni, additional, Kaitelidou, Daphne, additional, and Siskou, Olga, additional

Published
2022
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21. Prognostic significance of 24‐h blood pressure and variability indices in the outcome of acute ischaemic stroke.

Author

Kakaletsis, Nikolaos, Ntaios, George, Milionis, Haralampos, Karagiannaki, Anastasia, Chouvarda, Ioanna, Dourliou, Vasiliki, Chytas, Achileas, Hatzitolios, Apostolos I., and Savopoulos, Christos

Subjects
EVALUATION of medical care, CONFIDENCE intervals, ISCHEMIC stroke, SYSTOLIC blood pressure, MULTIVARIATE analysis, DIASTOLIC blood pressure, AMBULATORY blood pressure monitoring, DEATH, LOGISTIC regression analysis
Abstract

Background: The association between blood pressure (BP) levels and BP variability (BPV) following acute ischaemic stroke (AIS) and outcome remains controversial. Aims: To investigate the predictive value of systolic BP (SBP) and diastolic BP (DBP) and BPV measured using 24‐h ambulatory blood pressure monitoring (ABPM) methods during AIS regarding outcome. Methods: A total of 228 AIS patients (175 without prior disability) underwent ABPM every 20 min within 48 h from onset using an automated oscillometric device (TM 2430, A&D Company Ltd) during day time (7:00–22:59) and night time (23:00–6:59). Risk factors, stroke subtypes, clinical and laboratory findings were recorded. Mean BP parameters and several BPV indices were calculated. End‐points were death and unfavourable functional outcome (disability/death) at 3 months. Results: A total of 61 (26.7%) patients eventually died. Multivariate logistic regression analysis revealed that only mean night‐time DBP (hazard ratio (HR): 1.04; 95% confidence interval (CI): 1.00–1.07) was an independent prognostic factor of death. Of the 175 patients without prior disability, 79 (45.1%) finally met the end‐point of unfavourable functional outcome. Mean 24‐h SBP (HR: 1.03; 95% CI: 1.00–1.05), day‐time SBP (HR: 1.02; 95% CI: 1.00–1.05) and night‐time SBP (HR: 1.03; 95% CI: 1.01–1.05), SBP nocturnal decline (HR: 0.93; 95% CI: 0.88–0.99), mean 24‐h DBP (HR: 1.08; 95% CI: 1.03–1.13), day‐time DBP (HR: 1.07; 95% CI: 1.03–1.12) and night‐time DBP (HR: 1.06; 95% CI: 1.02–1.10) were independent prognostic factors of an unfavourable functional outcome. Conclusions: In contrast with BPV indices, ABPM‐derived BP levels and lower or absence of BP nocturnal decline in the acute phase are prognostic factors of outcome in AIS patients. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk

Author

Willeit, Peter, Tschiderer, Lena, Allara, Elias, Reuber, Kathrin, Seekircher, Lisa, Gao, Lu, Liao, Ximing, Lonn, Eva, Gerstein, Hertzel C, Yusuf, Salim, Brouwers, Frank P, Asselbergs, Folkert W, Van Gilst, Wiek, Anderssen, Sigmund A, Grobbee, Diederick E, Kastelein, John JP, Visseren, Frank LJ, Ntaios, George, Hatzitolios, Apostolos I, Savopoulos, Christos, Nieuwkerk, Pythia T, Stroes, Erik, Walters, Matthew, Higgins, Peter, Dawson, Jesse, Gresele, Paolo, Guglielmini, Giuseppe, Migliacci, Rino, Ezhov, Marat, Safarova, Maya, Balakhonova, Tatyana, Sato, Eiichi, Amaha, Mayuko, Nakamura, Tsukasa, Kapellas, Kostas, Jamieson, Lisa M, Skilton, Michael, Blumenthal, James A, Hinderliter, Alan, Sherwood, Andrew, Smith, Patrick J, Van Agtmael, Michiel A, Reiss, Peter, Van Vonderen, Marit GA, Kiechl, Stefan, Klingenschmid, Gerhard, Sitzer, Matthias, Stehouwer, Coen DA, Uthoff, Heiko, Zou, Zhi-Yong, Cunha, Ana R, Neves, Mario F, Witham, Miles D, Park, Hyun-Woong, Lee, Moo-Sik, Bae, Jang-Ho, Bernal, Enrique, Wachtell, Kristian, Kjeldsen, Sverre E, Olsen, Michael H, Preiss, David, Sattar, Naveed, Beishuizen, Edith, Huisman, Menno V, Espeland, Mark A, Schmidt, Caroline, Agewall, Stefan, Ok, Ercan, Aşçi, Gülay, De Groot, Eric, Grooteman, Muriel PC, Blankestijn, Peter J, Bots, Michiel L, Sweeting, Michael J, Thompson, Simon G, Lorenz, Matthias W, PROG-IMT And The Proof-ATHERO Study Groups, Group, PROG-IMT Study, Group, Proof-ATHERO Study, Vascular Medicine, Medical Psychology, APH - Mental Health, APH - Personalized Medicine, Experimental Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, Global Health, APH - Aging & Later Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ACS - Pulmonary hypertension & thrombosis, Ege Üniversitesi, MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, MUMC+: HVC Pieken Maastricht Studie (9), Interne Geneeskunde, MUMC+: MA Interne Geneeskunde (3), Allara, Elias [0000-0002-1634-8330], Apollo - University of Cambridge Repository, Cardiovascular Centre (CVC), Internal medicine, Nephrology, and ACS - Diabetes & metabolism

Subjects
Male, medicine.medical_specialty, Carotid Artery, Common, carotid intima-media thickness, LDL TREATMENT STRATEGIES, Myocardial Infarction, surrogate marker, TYPE-2 DIABETES-MELLITUS, HIV-INFECTED PATIENTS, 030204 cardiovascular system & hematology, Impaired glucose tolerance, EXTENDED-RELEASE NIACIN, 03 medical and health sciences, 0302 clinical medicine, IMPAIRED GLUCOSE-TOLERANCE, ESTROGEN PLUS PROGESTIN, cardiovascular disease, Physiology (medical), Internal medicine, BASE-LINE CHARACTERISTICS, medicine, Humans, CORONARY-HEART-DISEASE, 030212 general & internal medicine, Myocardial infarction, cardiovascular diseases, Stroke, Randomized Controlled Trials as Topic, clinical trials as topic, business.industry, Surrogate endpoint, Middle Aged, medicine.disease, Common, Clinical trial, meta-analysis, ARTERIAL-WALL THICKNESS, Intima-media thickness, JAPAN STATIN TREATMENT, Heart Disease Risk Factors, Relative risk, Meta-analysis, Cardiology, cardiovascular system, Female, Carotid Artery, Cardiology and Cardiovascular Medicine, business
Abstract

Background: To quantify the association between effects of interventions on carotid intima-media thickness (cIMT) progression and their effects on cardiovascular disease (CVD) risk. Methods: We systematically collated data from randomized, controlled trials. cIMT was assessed as the mean value at the common-carotid-artery; if unavailable, the maximum value at the common-carotid-artery or other cIMT measures were used. the primary outcome was a combined CVD end point defined as myocardial infarction, stroke, revascularization procedures, or fatal CVD. We estimated intervention effects on cIMT progression and incident CVD for each trial, before relating the 2 using a Bayesian meta-regression approach. Results: We analyzed data of 119 randomized, controlled trials involving 100 667 patients (mean age 62 years, 42% female). Over an average follow-up of 3.7 years, 12 038 patients developed the combined CVD end point. Across all interventions, each 10 mu m/y reduction of cIMT progression resulted in a relative risk for CVD of 0.91 (95% Credible Interval, 0.87-0.94), with an additional relative risk for CVD of 0.92 (0.87-0.97) being achieved independent of cIMT progression. Taken together, we estimated that interventions reducing cIMT progression by 10, 20, 30, or 40 mu m/y would yield relative risks of 0.84 (0.75-0.93), 0.76 (0.67-0.85), 0.69 (0.59-0.79), or 0.63 (0.52-0.74), respectively. Results were similar when grouping trials by type of intervention, time of conduct, time to ultrasound follow-up, availability of individual-participant data, primary versus secondary prevention trials, type of cIMT measurement, and proportion of female patients. Conclusions: the extent of intervention effects on cIMT progression predicted the degree of CVD risk reduction. This provides a missing link supporting the usefulness of cIMT progression as a surrogate marker for CVD risk in clinical trials., Austrian Science Fund (FWF)Austrian Science Fund (FWF) [P 32488]; Dr-Johannes-and-Hertha-Tuba Foundation; German Research FoundationGerman Research Foundation (DFG) [DFG Lo 1569/2-1, DFG Lo 1569/2-3]; excellence initiative "Competence Centers for Excellent Technologies" (COMET) of the Austrian Research Promotion Agency (FFG) "Research Center of Excellence in Vascular Ageing: Tyrol, VAS-Cage" - Bundesministerium fur Verkehr, Innovation und Technologie (B [843536]; Bundesministerium fur Bildung, Wissenschaft und Forschung (BMWFW); Wirtschaftsagentur Wien; Standortagentur Tirol, This work was supported by the Austrian Science Fund (FWF; P 32488); the Dr-Johannes-and-Hertha-Tuba Foundation; the German Research Foundation (DFG Lo 1569/2-1 and DFG Lo 1569/2-3); and the excellence initiative "Competence Centers for Excellent Technologies" (COMET) of the Austrian Research Promotion Agency (FFG) "Research Center of Excellence in Vascular Ageing: Tyrol, VAS-Cage" (K-Project No. 843536), funded by Bundesministerium fur Verkehr, Innovation und Technologie (BMVIT), Bundesministerium fur Bildung, Wissenschaft und Forschung (BMWFW), Wirtschaftsagentur Wien, and Standortagentur Tirol.

Published
2020
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39. Progression of conventional cardiovascular risk factors and vascular disease risk in individuals : insights from the PROG-IMT consortium

Author

Bahls, Martin, Lorenz, Matthias W., Doerr, Marcus, Gao, Lu, Kitagawa, Kazuo, Tuomainen, Tomi-Pekka, Agewall, Stefan, Berenson, Gerald, Catapano, Alberico L., Norata, Giuseppe D., Bots, Michiel L., van Gilst, Wiek, Asselbergs, Folkert W., Brouwers, Frank P., Uthoff, Heiko, Sander, Dirk, Poppert, Holger, Olsen, Michael Hecht, Empana, Jean Philippe, Schminke, Ulf, Baldassarre, Damiano, Veglia, Fabrizio, Franco, Oscar H., Kavousi, Maryam, de Groot, Eric, Mathiesen, Ellisiv B., Grigore, Liliana, Polak, Joseph F., Rundek, Tatjana, Stehouwer, Coen D. A., Skilton, Michael R., Hatzitolios, Apostolos, I, Savopoulos, Christos, Ntaios, George, Plichart, Matthieu, McLachlan, Stela, Lind, Lars, Willeit, Peter, Steinmetz, Helmuth, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Schmidt, Caroline, Willeit, Johann, Ducimetiere, Pierre, Price, Jackie F., Bergstrom, Goran, Kauhanen, Jussi, Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Sacco, Ralph L., Hofman, Albert, Voelzke, Henry, Thompson, Simon G., Bahls, Martin, Lorenz, Matthias W., Doerr, Marcus, Gao, Lu, Kitagawa, Kazuo, Tuomainen, Tomi-Pekka, Agewall, Stefan, Berenson, Gerald, Catapano, Alberico L., Norata, Giuseppe D., Bots, Michiel L., van Gilst, Wiek, Asselbergs, Folkert W., Brouwers, Frank P., Uthoff, Heiko, Sander, Dirk, Poppert, Holger, Olsen, Michael Hecht, Empana, Jean Philippe, Schminke, Ulf, Baldassarre, Damiano, Veglia, Fabrizio, Franco, Oscar H., Kavousi, Maryam, de Groot, Eric, Mathiesen, Ellisiv B., Grigore, Liliana, Polak, Joseph F., Rundek, Tatjana, Stehouwer, Coen D. A., Skilton, Michael R., Hatzitolios, Apostolos, I, Savopoulos, Christos, Ntaios, George, Plichart, Matthieu, McLachlan, Stela, Lind, Lars, Willeit, Peter, Steinmetz, Helmuth, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Schmidt, Caroline, Willeit, Johann, Ducimetiere, Pierre, Price, Jackie F., Bergstrom, Goran, Kauhanen, Jussi, Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Sacco, Ralph L., Hofman, Albert, Voelzke, Henry, and Thompson, Simon G.

Abstract

Aims Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. Methods and results An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events. Conclusion Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in ind

Published
2020
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40. Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk: Meta-Analysis of 119 Clinical Trials Involving 100,667 Patients

Author

Team Medisch, Circulatory Health, Global Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Interne Geneeskunde Vasculaire, MS Nefrologie, Cardiovasculaire Epidemiologie, Willeit, Peter, Tschiderer, Lena, Allara, Elias, Reuber, Kathrin, Seekircher, Lisa, Gao, Lu, Liao, Ximing, Lonn, Eva, Gerstein, Hertzel C, Yusuf, Salim, Brouwers, Frank P, Asselbergs, Folkert W, van Gilst, Wiek, Anderssen, Sigmund A, Grobbee, Diederick E, Kastelein, John J P, Visseren, Frank L J, Ntaios, George, Hatzitolios, Apostolos I, Savopoulos, Christos, Nieuwkerk, Pythia T, Stroes, Erik, Walters, Matthew, Higgins, Peter, Dawson, Jesse, Gresele, Paolo, Guglielmini, Giuseppe, Migliacci, Rino, Ezhov, Marat, Safarova, Maya, Balakhonova, Tatyana, Sato, Eiichi, Amaha, Mayuko, Nakamura, Tsukasa, Kapellas, Kostas, Jamieson, Lisa M, Skilton, Michael, Blumenthal, James A, Hinderliter, Alan, Sherwood, Andrew, Smith, Patrick J, van Agtmael, Michiel A, Reiss, Peter, van Vonderen, Marit G A, Kiechl, Stefan, Klingenschmid, Gerhard, Sitzer, Matthias, Stehouwer, Coen D A, Blankestijn, Peter J, Bots, Michiel L, PROG-IMT and the Proof-ATHERO Study Groups, Team Medisch, Circulatory Health, Global Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Interne Geneeskunde Vasculaire, MS Nefrologie, Cardiovasculaire Epidemiologie, Willeit, Peter, Tschiderer, Lena, Allara, Elias, Reuber, Kathrin, Seekircher, Lisa, Gao, Lu, Liao, Ximing, Lonn, Eva, Gerstein, Hertzel C, Yusuf, Salim, Brouwers, Frank P, Asselbergs, Folkert W, van Gilst, Wiek, Anderssen, Sigmund A, Grobbee, Diederick E, Kastelein, John J P, Visseren, Frank L J, Ntaios, George, Hatzitolios, Apostolos I, Savopoulos, Christos, Nieuwkerk, Pythia T, Stroes, Erik, Walters, Matthew, Higgins, Peter, Dawson, Jesse, Gresele, Paolo, Guglielmini, Giuseppe, Migliacci, Rino, Ezhov, Marat, Safarova, Maya, Balakhonova, Tatyana, Sato, Eiichi, Amaha, Mayuko, Nakamura, Tsukasa, Kapellas, Kostas, Jamieson, Lisa M, Skilton, Michael, Blumenthal, James A, Hinderliter, Alan, Sherwood, Andrew, Smith, Patrick J, van Agtmael, Michiel A, Reiss, Peter, van Vonderen, Marit G A, Kiechl, Stefan, Klingenschmid, Gerhard, Sitzer, Matthias, Stehouwer, Coen D A, Blankestijn, Peter J, Bots, Michiel L, and PROG-IMT and the Proof-ATHERO Study Groups

Published
2020

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