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226 results on '"Hatton, Paul V."'

21. Contributor contact details

Author

Wang, Yan, primary, Burgess, Diane J., additional, Lewis, A.L., additional, Bünger, Mark, additional, Gilmore, B.F., additional, Hamill, T.M., additional, Gorman, S.P., additional, Jones, D.S., additional, Avelar, Rui, additional, Jonker, Anneke, additional, Vedantham, K., additional, Chaterji, S., additional, Kitsongsermthon, J., additional, Park, K., additional, Garner, J., additional, Farrar, D., additional, Benson, R., additional, Milner, R., additional, Hatton, Paul V., additional, Palmer, Graham, additional, Koller, G., additional, Buranawat, B., additional, Di Silvio, L., additional, Young, A.M., additional, Silcock, D., additional, Williams, R.L., additional, Kearns, V.R., additional, Willis, Sean, additional, O’ Byrne, Vincent, additional, Clermont, G., additional, Alves, A., additional, Palazzi, X., additional, Boutrand, J.P., additional, Parsons, B.J., additional, Baxter, P.J., additional, Leppard, S., additional, and Greenbaum, John, additional

Published
2010
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30. Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging

Author

Clitherow, Katharina H., Murdoch, Craig, Spain, Sebastian Guy, Handler, Anna Mette, Colley, Helen E., Stie, Mai Bay, Nielsen, Hanne Morck, Janfelt, Christian, Hatton, Paul V., Jacobsen, Jette, Clitherow, Katharina H., Murdoch, Craig, Spain, Sebastian Guy, Handler, Anna Mette, Colley, Helen E., Stie, Mai Bay, Nielsen, Hanne Morck, Janfelt, Christian, Hatton, Paul V., and Jacobsen, Jette

Published
2019

32. Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging

Author

Clitherow, Katharina H., primary, Murdoch, Craig, additional, Spain, Sebastian Guy, additional, Handler, Anna Mette, additional, Colley, Helen E., additional, Stie, Mai Bay, additional, Mørck Nielsen, Hanne, additional, Janfelt, Christian, additional, Hatton, Paul V., additional, and Jacobsen, Jette, additional

Published
2019
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34. The osteogenic response of mesenchymal stromal cells to strontium‐substituted bioactive glasses

Author

Santocildes‐Romero, Martin E., Crawford, Aileen, Hatton, Paul V., Goodchild, Rebecca L., Reaney, Ian M., and Miller, Cheryl A.

Subjects
Male, Ceramics, Cell Survival, osteogenic differentiation, Real-Time Polymerase Chain Reaction, Regenerative Medicine, X-Ray Diffraction, Bone Marrow, Osteogenesis, Animals, Regeneration, strontium, Particle Size, Rats, Wistar, Research Articles, Temperature, bioactive glass, Cell Differentiation, Mesenchymal Stem Cells, Oxides, Calcium Compounds, Rats, Oxygen, Solubility, Microscopy, Electron, Scanning, Glass, real‐time PCR, mesenchymal stromal cells, Research Article
Abstract

Bioactive glasses are known to stimulate bone healing, and the incorporation of strontium has the potential to increase their potency. In this study, calcium oxide in the 45S5 bioactive glass composition was partially (50%, Sr50) or fully (100%, Sr100) substituted with strontium oxide on a molar basis. The effects of the substitution on bioactive glass properties were studied, including density, solubility, and in vitro cytotoxicity. Stimulation of osteogenic differentiation was investigated using mesenchymal stromal cells obtained from rat bone marrow. Strontium substitution resulted in altered physical properties including increased solubility. Statistically significant reductions in cell viability were observed with the addition of bioactive glass powders to culture medium. Specifically, addition of ≥ 13.3 mg/ml of 45S5 bioactive glass or Sr50, or ≥ 6.7 mg/ml of Sr100, resulted in significant inhibition. Real‐time PCR analyses detected the upregulation of genes associated with osteoblastic differentiation in the presence of all bioactive glass compositions. Some genes, including Alpl and Bglap, were further stimulated in the presence of Sr50 and Sr100. It was concluded that strontium‐substituted bioactive glasses promoted osteogenesis in a differentiating bone cell culture model and, therefore, have considerable potential for use as improved bioactive glasses for bone tissue regeneration. © 2015 The Authors. Journal of Tissue Engineering and Regenerative Medicine Published by John Wiley & Sons Ltd.

Published
2015

35. Novel Bilayer Mucoadhesive Patches for Delivery of Clobetasol-17-Propionate to the Oral Mucosa to Treat Oral Lichen Planus; an in Vitro and in Vivo Evaluation

Author

Colley, Helen E., primary, Said, Zulfahami, additional, Santocildes-Romero, Martin E., additional, Baker, Sarah R., additional, D'Apice, Katie, additional, Hansen, Jens, additional, Madsen, Lars Siim, additional, Thornhill, Martin H., additional, Hatton, Paul V., additional, and Murdoch, Craig, additional

Published
2018
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43. Medium-Chain Fatty Acids Released from Polymeric Electrospun Patches Inhibit Candida albicansGrowth and Reduce the Biofilm Viability

Author

Clitherow, Katharina H., Binaljadm, Tahani M., Hansen, Jens, Spain, Sebastian G., Hatton, Paul V., and Murdoch, Craig

Abstract

Oral candidiasis is a very common oral condition among susceptible individuals, with the main causative organism being the fungus Candida albicans. Current drug delivery systems to the oral mucosa are often ineffective because of short drug/tissue contact times as well as increased prevalence of drug-resistant Candidastrains. We evaluated the potency of saturated fatty acids as antifungal agents and investigated their delivery by novel electrospun mucoadhesive oral patches using agar disk diffusion and biofilm assays. Octanoic (C8) and nonanoic (C9) acids were the most effective at inhibiting C. albicansgrowth on disk diffusion assays, both in solution or when released from polycaprolactone (PCL) or polyvinylpyrrolidone/RS100 (PVP/RS100) electrospun patches. In contrast, dodecanoic acid (C12) displayed the most potent antifungal activity against pre-existing C. albicansbiofilms in solution or when released by PCL or PVP/RS100 patches. Both free and patch-released saturated fatty acids displayed a significant toxicity to wild-type and azole-resistant strains of C. albicans. These data not only provide evidence that certain saturated fatty acids have the potential to be used as antifungal agents but also demonstrate that this therapy could be delivered directly to Candida-infected sites using electrospun mucoadhesive patches, demonstrating a potential new therapeutic approach to treat oral thrush.

Published
2020
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48. Electrospun F18 Bioactive Glass/PCL--Poly (ε-caprolactone)--Membrane for Guided Tissue Regeneration.

Author

Hidalgo Pitaluga, Lucas, Trevelin Souza, Marina, Dutra Zanotto, Edgar, Santocildes Romero, Martin Eduardo, and Hatton, Paul V.

Subjects
POLYCAPROLACTONE, GUIDED tissue regeneration, POLYMERIC membranes, ELECTROSPINNING, BONE injuries, BIOACTIVE glasses, TENSILE strength, OSTEOBLASTS, THERAPEUTICS
Abstract

Barrier membranes that are used for guided tissue regeneration (GTR) therapy usually lack bioactivity and the capability to promote new bone tissue formation. However, the incorporation of an osteogenic agent into polymeric membranes seems to be the most assertive strategy to enhance their regenerative potential. Here, the manufacturing of composite electrospun membranes made of poly ("-caprolactone) (PCL) and particles of a novel bioactive glass composition (F18) is described. The membranes were mechanically and biologically tested with tensile strength tests and tissue culture with MG-63 osteoblast-like cell line, respectively. The PCL-F18 composite membranes demonstrated no increased cytotoxicity and an enhanced osteogenic potential when compared to pure PCL membranes. Moreover, the addition of the bioactive phase increased the membrane tensile strength. These preliminary results suggested that these new membranes can be a strong candidate for small bone injuries treatment by GTR technique. [ABSTRACT FROM AUTHOR]

Published
2018
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49. The Effect of RANKL/OPG Balance on Reducing Implant Complications.

Author

Kapasa, Elizabeth R., Giannoudis, Peter V., Xiaodong Jia, Hatton, Paul V., and Yang, Xuebin B.

Subjects
BONE regeneration, OSTEOPROTEGERIN, TRANCE protein
Abstract

Despite the phenomenal success of implants particularly in the realms of dentistry and orthopaedics, there are still challenges to overcome. The failure of implants resulting from infection, prosthetic loosening, and non-union continue to be the most notorious examples. The cascade of fracture healing and bone repair, especially with the presence of an implant, is complex because it involves a multifaceted immune response alongside the intricate process of bone formation and remodelling. Bone loss is a serious clinical problem that is frequently accompanied by chronic inflammation, illustrating that there is a convoluted relationship between inflammation and bone erosion. The effects of pro-inflammatory factors play a significant role in initiating and maintaining osteoclastogenesis that results in bone resorption by osteoclasts. This is because there is a disruption of the relative ratio between Receptor Activator of Nuclear Factor κB-Ligand (RANKL) and osteoprotegerin (OPG), which is central to modulating bone repair and remodelling. This review aims to provide a background to the bone remodelling process, the bone repair cascade post-implantation, and the associated complications. Furthermore, current clinical solutions that can influence bone formation via either internal or extrinsic mechanisms will be described. These efficacious treatments for osteolysis via targeting the RANKL/OPG ratio may be crucial to reducing the incidence of related implant failures in the future. [ABSTRACT FROM AUTHOR]

Published
2017
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50. Poly(2-ethyl-(2-pyrrolidone) methacrylate) and hyaluronic acid-based hydrogels for the engineering of a cartilage-like tissue using bovine articular chondrocytes

Author

Magalhães, Joana, Crawford, Aileen, Hatton, Paul V., Blanco, Francisco J., San Román, Julio, Magalhães, Joana, Crawford, Aileen, Hatton, Paul V., Blanco, Francisco J., and San Román, Julio

Abstract

Poly(2-ethyl-(2-pyrrolidone)methacrylate)-hyaluronic acid hydrogels based on the free radical polymerization of 2-ethyl-(2-pyrrolidone)methacrylate combined with hyaluronic acid, using N,N′-methylenebisacrylamide or triethylene glycol dimethacrylate, as cross-linking agents, were considered for tissue engineering applications. Bovine articular chondrocytes were seeded onto the poly(2-ethyl-(2-pyrrolidone)methacrylate)-hyaluronic acid hydrogels, under orbital agitation, for a total of 40 days. The engineered cell-constructs were characterized according to cell proliferation, morphology and distribution as well as the biochemical composition of the tissue formed. The chondrocytes were found to be attached and presented a typical spherical morphology. Cells were able to proliferate and synthesize a hyaline-like matrix rich in glycosaminoglycans and collagen type II which were mainly located on the superficial area. Increased content of individual components poly(2-ethyl-(2-pyrrolidone)methacrylate) and hyaluronic acid, in triethylene glycol dimethacrylate-cross-linked networks led to enhanced cell distribution and total glycosaminoglycans content, supporting their potential application for the repair of cartilaginous tissues.

Published
2014

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