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1. Overview of JET results for optimising ITER operation

Author: Mailloux, J, Abid, N, Abraham, K, Abreu, P, Adabonyan, O, Adrich, P, Afanasev, V, Afzal, M, Ahlgren, T, Aho-Mantila, L, Aiba, N, Airila, M, Akhtar, M, Albanese, R, Alderson-Martin, M, Alegre, D, Aleiferis, S, Aleksa, A, Alekseev, A, Alessi, E, Aleynikov, P, Algualcil, J, Ali, M, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, Amosov, V, Sunden, E, Andrew, P, Angelini, B, Angioni, C, Antoniou, I, Appel, L, Appelbee, C, Aria, S, Ariola, M, Artaserse, G, Arter, W, Artigues, V, Asakura, N, Ash, A, Ashikawa, N, Aslanyan, V, Astrain, M, Asztalos, O, Auld, D, Auriemma, F, Austin, Y, Avotina, L, Aymerich, E, Baciero, A, Bairaktaris, F, Balbin, J, Balbinot, L, Balboa, I, Balden, M, Balshaw, C, Balshaw, N, Bandaru, V, Banks, J, Baranov, Y, Barcellona, C, Barnard, A, Barnard, M, Barnsley, R, Barth, A, Baruzzo, M, Barwell, S, Bassan, M, Batista, A, Batistoni, P, Baumane, L, Bauvir, B, Baylor, L, Beaumont, P, Beckett, D, Begolli, A, Beidler, M, Bekris, N, Beldishevski, M, Belli, E, Belli, F, Belonohy, E, Ben Yaala, M, Benayas, J, Bentley, J, Bergsaker, H, Bernardo, J, Bernert, M, Berry, M, Bertalot, L, Betar, H, Beurskens, M, Bickerton, S, Bieg, B, Bielecki, J, Bierwage, A, Biewer, T, Bilato, R, Bilkova, P, Birkenmeier, G, Bishop, H, Bizarro, J, Blackburn, J, Blanchard, P, Blatchford, P, Bobkov, V, Boboc, A, Bohm, P, Bohm, T, Bolshakova, I, Bolzonella, T, Bonanomi, N, Bonfiglio, D, Bonnin, X, Bonofiglo, P, Boocock, S, Booth, A, Booth, J, Borba, D, Borodin, D, Borodkina, I, Boulbe, C, Bourdelle, C, Bowden, M, Boyd, K, Mihalic, I, Bradnam, S, Braic, V, Brandt, L, Bravanec, R, Breizman, B, Brett, A, Brezinsek, S, Brix, M, Bromley, K, Brown, B, Brunetti, D, Buckingham, R, Buckley, M, Budny, R, Buermans, J, Bufferand, H, Buratti, P, Burgess, A, Buscarino, A, Busse, A, Butcher, D, de la Cal, E, Calabro, G, Calacci, L, Calado, R, Camenen, Y, Canal, G, Cannas, B, Cappelli, M, Carcangiu, S, Card, P, Cardinali, A, Carman, P, Carnevale, D, Carr, M, Carralero, D, Carraro, L, Carvalho, I, Carvalho, P, Casiraghi, I, Casson, F, Castaldo, C, Catalan, J, Catarino, N, Causa, F, Cavedon, M, Cecconello, M, Challis, C, Chamberlain, B, Chang, C, Chankin, A, Chapman, B, Chernyshova, M, Chiariello, A, Chmielewski, P, Chomiczewska, A, Chone, L, Ciraolo, G, Ciric, D, Clark, M, Clarkson, R, Clements, C, Cleverly, M, Coad, J, Coates, P, Cobalt, A, Coccorese, V, Coelho, R, Coenen, J, Coffey, I, Colangeli, A, Colas, L, Collins, C, Collins, J, Collins, S, Conka, D, Conroy, S, Conway, B, Conway, N, Coombs, D, Cooper, P, Cooper, S, Corradino, C, Corrigan, G, Coster, D, Cox, P, Craciunescu, T, Cramp, S, Crapper, C, Craven, D, Craven, R, Esposito, M, Croci, G, Croft, D, Croitoru, A, Crombe, K, Cronin, T, Cruz, N, Crystal, C, Cseh, G, Cufar, A, Cullen, A, Curuia, M, Czarski, T, Dabirikhah, H, Dal Molin, A, Dale, E, Dalgliesh, P, Dalley, S, Dankowski, J, David, P, Davies, A, Davies, S, Davis, G, Dawson, K, Dawson, S, Day, I, De Bock, M, De Temmerman, G, De Tommasi, G, Deakin, K, Deane, J, Dejarnac, R, Del Sarto, D, Delabie, E, Del-Castillo-Negrete, D, Dempsey, A, Dendy, R, Devynck, P, Di Siena, A, Di Troia, C, Dickson, T, Dinca, P, Dittmar, T, Dobrashian, J, Doerner, R, Donne, A, Dorling, S, Dormido-Canto, S, Douai, D, Dowson, S, Doyle, R, Dreval, M, Drewelow, P, Drews, P, Drummond, G, Duckworth, P, Dudding, H, Dumont, R, Dumortier, P, Dunai, D, Dunatov, T, Dunne, M, Durodie, F, Dux, R, Dvornova, A, Eastham, R, Edwards, J, Eich, T, Eichorn, A, Eidietis, N, Eksaeva, A, El Haroun, H, Ellwood, G, Elsmore, C, Embreus, O, Emery, S, Ericsson, G, Eriksson, B, Eriksson, F, Eriksson, J, Eriksson, L, Ertmer, S, Esquembri, S, Esquisabel, A, Estrada, T, Evans, G, Evans, S, Fable, E, Fagan, D, Faitsch, M, Falessi, M, Fanni, A, Farahani, A, Farquhar, I, Fasoli, A, Faugeras, B, Fazinic, S, Felici, F, Felton, R, Fernandes, A, Fernandes, H, Ferrand, J, Ferreira, D, Ferreira, J, Ferro, G, Fessey, J, Ficker, O, Field, A, Figueiredo, A, Figueiredo, J, Fil, A, Fil, N, Finburg, P, Fiorucci, D, Fischer, U, Fishpool, G, Fittill, L, Fitzgerald, M, Flammini, D, Flanagan, J, Flinders, K, Foley, S, Fonnesu, N, Fontana, M, Fontdecaba, J, Forbes, S, Formisano, A, Fornal, T, Fortuna, L, Fortuna-Zalesna, E, Fortune, M, Fowler, C, Fransson, E, Frassinetti, L, Freisinger, M, Fresa, R, Fridstrom, R, Frigione, D, Fulop, T, Furseman, M, Fusco, V, Futatani, S, Gadariya, D, Gal, K, Galassi, D, Galazka, K, Galeani, S, Gallart, D, Galvao, R, Gao, Y, Garcia, J, Garcia-Munoz, M, Gardener, M, Garzotti, L, Gaspar, J, Gatto, R, Gaudio, P, Gear, D, Gebhart, T, Gee, S, Gelfusa, M, George, R, Gerasimov, S, Gervasini, G, Gethins, M, Ghani, Z, Gherendi, M, Ghezzi, F, Giacalone, J, Giacomelli, L, Giacometti, G, Gibson, C, Gibson, K, Gil, L, Gillgren, A, Gin, D, Giovannozzi, E, Giroud, C, Glen, R, Gloggler, S, Goff, J, Gohil, P, Goloborodko, V, Gomes, R, Goncalves, B, Goniche, M, Goodyear, A, Gore, S, Gorini, G, Gorler, T, Gotts, N, Goulding, R, Gow, E, Graham, B, Graves, J, Greuner, H, Grierson, B, Griffiths, J, Griph, S, Grist, D, Gromelski, W, Groth, M, Grove, R, Gruca, M, Guard, D, Gupta, N, Gurl, C, Gusarov, A, Hackett, L, Hacquin, S, Hager, R, Hagg, L, Hakola, A, Halitovs, M, Hall, S, Hallworth-Cook, S, Ham, C, Hamaguchi, D, Hamed, M, Hamlyn-Harris, C, Hammond, K, Harford, E, Harrison, J, Harting, D, Hatano, Y, Hatch, D, Haupt, T, Hawes, J, Hawkes, N, Hawkins, J, Hayashi, T, Hazael, S, Hazel, S, Heesterman, P, Heidbrink, B, Helou, W, Hemming, O, Henderson, S, Henriques, R, Hepple, D, Herfindal, J, Hermon, G, Hill, J, Hillesheim, J, Hizanidis, K, Hjalmarsson, A, Ho, A, Hobirk, J, Hoenen, O, Hogben, C, Hollingsworth, A, Hollis, S, Hollmann, E, Holzl, M, Homan, B, Hook, M, Hopley, D, Horsley, D, Horsten, N, Horton, A, Horton, L, Horvath, L, Hotchin, S, Howell, R, Hu, Z, Huber, A, Huber, V, Huddleston, T, Huijsmans, G, Huynh, P, Hynes, A, Iliasova, M, Imrie, D, Imrisek, M, Ingleby, J, Innocente, P, Bjork, K, Isernia, N, Ivanova-Stanik, I, Ivings, E, Jablonski, S, Jachmich, S, Jackson, T, Jacquet, P, Jarleblad, H, Jaulmes, F, Rodriguez, J, Jepu, I, Joffrin, E, Johnson, R, Johnson, T, Johnston, J, Jones, C, Jones, G, Jones, L, Jones, N, Jones, T, Joyce, A, Juarez, R, Juvonen, M, Kaltiaisenaho, T, Kaniewski, J, Kantor, A, Kappatou, A, Karhunen, J, Karkinsky, D, Kashchuk, Y, Kaufman, M, Kaveney, G, Kazakov, Y, Kazantzidis, V, Keeling, D, Kelly, R, Kempenaars, M, Kennedy, C, Kennedy, D, Kent, J, Khan, K, Khilkevich, E, Kiefer, C, Kilpelainen, J, Kim, C, Kim, H, Kim, S, King, D, King, R, Kinna, D, Kiptily, V, Kirjasuo, A, Kirov, K, Kirschner, A, Kiviniemi, T, Kizane, G, Klas, M, Klepper, C, Klix, A, Kneale, G, Knight, M, Knight, P, Knights, R, Knipe, S, Knolker, M, Knott, S, Kocan, M, Kochl, F, Kodeli, I, Kolesnichenko, Y, Kominis, Y, Kong, M, Korovin, V, Kos, B, Kos, D, Koslowski, H, Kotschenreuther, M, Koubiti, M, Koziol, K, Krasilnikov, A, Krasilnikov, V, Kresina, M, Krieger, K, Krishnan, N, Krivska, A, Kruezi, U, Kukushkin, A, Kumpulainen, H, Kurki-Suonio, T, Kurotaki, H, Kwak, S, Kwon, O, Laguardia, L, Lagzdina, E, Lahtinen, A, Laing, A, Lam, N, Lambertz, H, Lane, B, Lane, C, Neto, E, Lawson, K, Lazaros, A, Lazzaro, E, Learoyd, G, Lee, C, Lee, S, Leerink, S, Leeson, T, Lefebvre, X, Leggate, H, Lehmann, J, Lehnen, M, Leichtle, D, Leipold, F, Lengar, I, Lennholm, M, Gutierrez, E, Lepiavko, B, Leppanen, J, Lerche, E, Lescinskis, A, Lewis, J, Leysen, W, Li, L, Li, Y, Likonen, J, Linsmeier, C, Lipschultz, B, Litaudon, X, Litherland-Smith, E, Liu, F, Loarer, T, Loarte, A, Lobel, R, Lomanowski, B, Lomas, P, Lopez, J, Lorenzini, R, Loreti, S, Losada, U, Loschiavo, V, Loughlin, M, Louka, Z, Lovell, J, Lowe, T, Lowry, C, Lubbad, S, Luce, T, Lucock, R, Lukin, A, Luna, C, de la Luna, E, Lungaroni, M, Lungu, C, Lunt, T, Lutsenko, V, Lyons, B, Lyssoivan, A, Machielsen, M, Macusova, E, Maenpaa, R, Maggi, C, Maggiora, R, Magness, M, Mahesan, S, Maier, H, Maingi, R, Malinowski, K, Manas, P, Mantica, P, Mantsinen, M, Manyer, J, Manzanares, A, Maquet, P, Marceca, G, Marcenko, N, Marchetto, C, Marchuk, O, Mariani, A, Mariano, G, Marin, M, Marinelli, M, Markovic, T, Marocco, D, Marot, L, Marsden, S, Marsh, J, Marshall, R, Martellucci, L, Martin, A, Martone, R, Maruyama, S, Maslov, M, Masuzaki, S, Matejcik, S, Mattei, M, Matthews, G, Matveev, D, Matveeva, E, Mauriya, A, Maviglia, F, Mayer, M, Mayoral, M, Mazzi, S, Mazzotta, C, Mcadams, R, Mccarthy, P, Mcclements, K, Mcclenaghan, J, Mccullen, P, Mcdonald, D, Mcguckin, D, Mchugh, D, Mcintyre, G, Mckean, R, Mckehon, J, Mcmillan, B, Mcnamee, L, Mcshee, A, Meakins, A, Medley, S, Meekes, C, Meghani, K, Meigs, A, Meisl, G, Meitner, S, Menmuir, S, Mergia, K, Merriman, S, Mertens, P, Meshchaninov, S, Messiaen, A, Michling, R, Middleton, P, Middleton-Gear, D, Mietelski, J, Milanesio, D, Milani, E, Militello, F, Asp, A, Milnes, J, Milocco, A, Miloshevsky, G, Minghao, C, Minucci, S, Miron, I, Miyamoto, M, Mlynar, J, Moiseenko, V, Monaghan, P, Monakhov, I, Moody, T, Moon, S, Mooney, R, Moradi, S, Morales, J, Morales, R, Mordijck, S, Moreira, L, Morgan, L, Moro, F, Morris, J, Morrison, K, Msero, L, Moulton, D, Mrowetz, T, Mundy, T, Muraglia, M, Murari, A, Muraro, A, Muthusonai, N, Na, Y, Nabais, F, Naden, M, Naish, J, Naish, R, Napoli, F, Nardon, E, Naulin, V, Nave, M, Nedzelskiy, I, Nemtsev, G, Nesenevich, V, Nestoras, I, Neu, R, Neverov, V, Ng, S, Nicassio, M, Nielsen, A, Nina, D, Nishijima, D, Noble, C, Nobs, C, Nocente, M, Nodwell, D, Nordlund, K, Nordman, H, Normanton, R, Noterdaeme, J, Nowak, S, Nunn, E, Nystrom, H, Oberparleiter, M, Obryk, B, O'Callaghan, J, Odupitan, T, Oliver, H, Olney, R, O'Mullane, M, Ongena, J, Organ, E, Orsitto, F, Orszagh, J, Osborne, T, Otin, R, Otsuka, T, Owen, A, Oya, Y, Oyaizu, M, Paccagnella, R, Pace, N, Packer, L, Paige, S, Pajuste, E, Palade, D, Pamela, S, Panadero, N, Panontin, E, Papadopoulos, A, Papp, G, Papp, P, Parail, V, Pardanaud, C, Parisi, J, Diaz, F, Parsloe, A, Parsons, M, Parsons, N, Passeri, M, Patel, A, Pau, A, Pautasso, G, Pavlichenko, R, Pavone, A, Pawelec, E, Soldan, C, Peacock, A, Pearce, M, Peluso, E, Penot, C, Pepperell, K, Pereira, R, Pereira, T, Cippo, E, Pereslavtsev, P, von Thun, C, Pericoli, V, Perry, D, Peterka, M, Petersson, P, Petravich, G, Petrella, N, Peyman, M, Pillon, M, Pinches, S, Pintsuk, G, de Sa, W, dos Reis, A, Piron, C, Pionr, L, Pironti, A, Pitts, R, van de Plassche, K, Platt, N, Plyusnin, V, Podesta, M, Pokol, G, Poli, F, Pompilian, O, Popovichev, S, Poradzinski, M, Porfiri, M, Porkolab, M, Porosnicu, C, Porton, M, Poulipoulis, G, Predebon, I, Prestopino, G, Price, C, Price, D, Price, M, Primetzhofer, D, Prior, P, Provatas, G, Pucella, G, Puglia, P, Purahoo, K, Pusztai, I, Putignano, O, Putterich, T, Quercia, A, Rachlew, E, Radulescu, G, Radulovic, V, Rainford, M, Raj, P, Ralph, G, Ramogida, G, Rasmussen, D, Rasmussen, J, Ratta, G, Ratynskaia, S, Rebai, M, Refy, D, Reichle, R, Reinke, M, Reiser, D, Reux, C, Reynolds, S, Richiusa, M, Richyal, S, Rigamonti, D, Rimini, F, Risner, J, Riva, M, Rivero-Rodriguez, J, Roach, C, Robins, R, Robinson, S, Robson, D, Rodionov, R, Rodrigues, P, Ramos, M, Rodriguez-Fernandez, P, Romanelli, F, Romanelli, M, Romanelli, S, Romazanov, J, Rossi, R, Rowe, S, Rowlands, D, Rubel, M, Rubinacci, G, Rubino, G, Ruchko, L, Ruiz, M, Ruiz, J, Ruset, C, Rzadkiewicz, J, Saarelma, S, Safi, E, Sahlberg, A, Salewski, M, Salmi, A, Salmon, R, Salzedas, F, Sanders, I, Sandiford, D, Santos, B, Santucci, A, Sarkimaki, K, Sarwar, R, Sarychev, I, Sauter, O, Sauwan, P, Scapin, N, Schluck, F, Schmid, K, Schmuck, S, Schneider, M, Schneider, P, Schworer, D, Scott, G, Scott, M, Scraggs, D, Scully, S, Segato, M, Seo, J, Sergienko, G, Sertoli, M, Sharapov, S, Shaw, A, Sheikh, H, Sheikh, U, Shepherd, A, Shevelev, A, Shigin, P, Shinohara, K, Shiraiwa, S, Shiraki, D, Short, M, Sias, G, Silburn, S, Silva, A, Silva, C, Silva, J, Silvagni, D, Simfukwe, D, Simpson, J, Sinclair, D, Sipila, S, Sips, A, Siren, P, Sirinelli, A, Sjostrand, H, Skinner, N, Slater, J, Smith, N, Smith, P, Snell, J, Snoep, G, Snoj, L, Snyder, P, Soare, S, Solano, E, Solokha, V, Somers, A, Sommariva, C, Soni, K, Sorokovoy, E, Sos, M, Sousa, J, Sozzi, C, Spagnolo, S, Spelzini, T, Spineanu, F, Spong, D, Sprada, D, Sridhar, S, Srinivasan, C, Stables, G, Staebler, G, Stamatelatos, I, Stancar, Z, Staniec, P, Stankunas, G, Stead, M, Stefanikova, E, Stephen, A, Stephens, J, Stevenson, P, Stojanov, M, Strand, P, Strauss, H, Strikwerda, S, Strom, P, Stuart, C, Studholme, W, Subramani, M, Suchkov, E, Sumida, S, Sun, H, Susts, T, Svensson, J, Svoboda, J, Sweeney, R, Sytnykov, D, Szabolics, T, Szepesi, G, Tabia, B, Tadic, T, Tal, B, Tala, T, Tallargio, A, Tamain, P, Tan, H, Tanaka, K, Tang, W, Tardocchi, M, Taylor, D, Teimane, A, Telesca, G, Teplova, N, Teplukhina, A, Terentyev, D, Terra, A, Terranova, D, Terranova, N, Testa, D, Tholerus, E, Thomas, J, Thoren, E, Thorman, A, Tierens, W, Tinguely, R, Tipton, A, Todd, H, Tokitani, M, Tolias, P, Tomes, M, Tookey, A, Torikai, Y, von Toussaint, U, Tsavalas, P, Tskhakaya, D, Turner, I, Turner, M, Turnyanskiy, M, Tvalashvili, G, Tyrrell, S, Tyshchenko, M, Uccello, A, Udintsev, V, Urbanczyk, G, Vadgama, A, Valcarcel, D, Valisa, M, Olivares, P, Vallhagen, O, Van Eester, D, Varje, J, Vartanian, S, Vasilopoulou, T, Vayakis, G, Vecsei, M, Vega, J, Ventre, S, Verdoolaege, G, Verona, C, Rinati, G, Veshchev, E, Vianello, N, Viezzer, E, Vignitchouk, L, Vila, R, Villari, R, Villone, F, Vincenzi, P, Vinyar, I, Viola, B, Virtanen, A, Vitins, A, Vizvary, Z, Vlad, G, Vlad, M, Vondracek, P, de Vries, P, Wakeling, B, Walkden, N, Walker, M, Walker, R, Walsh, M, Wang, E, Wang, N, Warder, S, Warren, R, Waterhouse, J, Watts, C, Wauters, T, Weckmann, A, Maxwell, H, Weiland, M, Weisen, H, Weiszflog, M, Welch, P, Wendler, N, West, A, Wheatley, M, Wheeler, S, Whitehead, A, Whittaker, D, Widdowson, A, Wiesen, S, Wilkinson, J, Williams, J, Willoughby, D, Wilson, I, Wilson, J, Wilson, T, Wischmeier, M, Wise, P, Withenshaw, G, Withycombe, A, Witts, D, Wojcik-Gargula, A, Wolfrum, E, Wood, R, Woodley, C, Woodley, R, Woods, B, Wright, J, Xu, T, Yadikin, D, Yajima, M, Yakovenko, Y, Yang, Y, Yanling, W, Yanovskiy, V, Young, I, Young, R, Zabolockis, R, Zacks, J, Zagorski, R, Zaitsev, F, Zakharov, L, Zarins, A, Fernandez, D, Zastrow, K, Zayachuk, Y, Zerbini, M, Zhang, W, Zhou, Y, Zlobinski, M, Zocco, A, Zohar, A, Zoita, V, Zoletnik, S, Zotta, V, Zoulias, I, Zwingmann, W, Zychor, I, Alekseev, AG, Sunden, EA, Angelini, BM, Appel, LC, Bandaru, VK, Baranov, YF, Beaumont, PS, Bizarro, JPS, Mihalic, IB, Bradnam, SC, Carvalho, IS, Casson, FJ, Catalan, JP, Challis, CD, Chang, CS, Coad, JP, Coenen, JW, Coffey, IH, Conway, NJ, Esposito, MC, Day, IE, Dendy, RO, Doerner, RP, Donne, AJH, Eriksson, LG, Esquisabel, AL, Ferreira, DR, Field, AR, Fontdecaba, JM, Gerasimov, SN, Giacalone, JC, Gibson, KJ, Graves, JP, Hall, SA, Ham, CJ, Harrison, JR, Hatch, DR, Hawkes, NC, Henderson, SS, Henriques, RB, Hillesheim, JC, Horton, LD, Huijsmans, GTA, Bjork, KI, Rodriguez, JJ, Kazakov, YO, Keeling, DL, Kim, HT, Kim, SH, King, DB, Kiptily, VG, Kirov, KK, Koslowski, HR, Kukushkin, AB, Kwon, OJ, Lambertz, HT, Neto, EL, Lawson, KD, Lee, SE, Leggate, HJ, Gutierrez, EL, Lomas, PJ, Lopez, JM, Loschiavo, VP, Lungu, CP, Maggi, CF, Mantsinen, MJ, Martin, AJ, Matthews, GF, Mayoral, ML, McAdams, R, McCarthy, PJ, McClements, KG, McClenaghan, J, McCullen, P, McDonald, DC, McGuckin, D, McHugh, D, McIntyre, G, McKean, R, McKehon, J, McMillan, B, McNamee, L, McShee, A, Meekes, CJ, Meigs, AG, Asp, AM, Morales, RB, Morrison, KM, Na, YS, Nave, MFF, Neverov, VS, Nielsen, AH, Nobs, CR, Noterdaeme, JM, Oliver, HJC, Packer, LW, Pamela, SJP, Parail, VV, Diaz, FP, Soldan, CP, Cippo, EP, von Thun, CP, de Sa, WP, dos Reis, AP, van de Plassche, KL, Poli, FM, Pompilian, OG, Porfiri, MT, Rasmussen, JJ, Richiusa, ML, Rimini, FG, Roach, CM, Ramos, MR, Ruiz, JR, Schneider, PA, Sharapov, SE, Silburn, SA, Sipila, SK, Sips, ACC, Solano, ER, Strauss, HR, Stuart, CI, Sun, HJ, Susts, TE, Teimane, AS, Tinguely, RA, Turner, MM, Olivares, PV, Rinati, GV, Virtanen, AJ, Walkden, NR, Maxwell, HW, Williams, JC, Wright, JC, Zabolockis, RJ, Zaitsev, FS, Fernandez, DZ, Zastrow, KD, Zotta, VK, Mailloux, J, Abid, N, Abraham, K, Abreu, P, Adabonyan, O, Adrich, P, Afanasev, V, Afzal, M, Ahlgren, T, Aho-Mantila, L, Aiba, N, Airila, M, Akhtar, M, Albanese, R, Alderson-Martin, M, Alegre, D, Aleiferis, S, Aleksa, A, Alekseev, A, Alessi, E, Aleynikov, P, Algualcil, J, Ali, M, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, Amosov, V, Sunden, E, Andrew, P, Angelini, B, Angioni, C, Antoniou, I, Appel, L, Appelbee, C, Aria, S, Ariola, M, Artaserse, G, Arter, W, Artigues, V, Asakura, N, Ash, A, Ashikawa, N, Aslanyan, V, Astrain, M, Asztalos, O, Auld, D, Auriemma, F, Austin, Y, Avotina, L, Aymerich, E, Baciero, A, Bairaktaris, F, Balbin, J, Balbinot, L, Balboa, I, Balden, M, Balshaw, C, Balshaw, N, Bandaru, V, Banks, J, Baranov, Y, 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Donne, AJH, Eriksson, LG, Esquisabel, AL, Ferreira, DR, Field, AR, Fontdecaba, JM, Gerasimov, SN, Giacalone, JC, Gibson, KJ, Graves, JP, Hall, SA, Ham, CJ, Harrison, JR, Hatch, DR, Hawkes, NC, Henderson, SS, Henriques, RB, Hillesheim, JC, Horton, LD, Huijsmans, GTA, Bjork, KI, Rodriguez, JJ, Kazakov, YO, Keeling, DL, Kim, HT, Kim, SH, King, DB, Kiptily, VG, Kirov, KK, Koslowski, HR, Kukushkin, AB, Kwon, OJ, Lambertz, HT, Neto, EL, Lawson, KD, Lee, SE, Leggate, HJ, Gutierrez, EL, Lomas, PJ, Lopez, JM, Loschiavo, VP, Lungu, CP, Maggi, CF, Mantsinen, MJ, Martin, AJ, Matthews, GF, Mayoral, ML, McAdams, R, McCarthy, PJ, McClements, KG, McClenaghan, J, McCullen, P, McDonald, DC, McGuckin, D, McHugh, D, McIntyre, G, McKean, R, McKehon, J, McMillan, B, McNamee, L, McShee, A, Meekes, CJ, Meigs, AG, Asp, AM, Morales, RB, Morrison, KM, Na, YS, Nave, MFF, Neverov, VS, Nielsen, AH, Nobs, CR, Noterdaeme, JM, Oliver, HJC, Packer, LW, Pamela, SJP, Parail, VV, Diaz, FP, Soldan, CP, Cippo, EP, von Thun, CP, de Sa, WP, dos Reis, AP, van de Plassche, KL, Poli, FM, Pompilian, OG, Porfiri, MT, Rasmussen, JJ, Richiusa, ML, Rimini, FG, Roach, CM, Ramos, MR, Ruiz, JR, Schneider, PA, Sharapov, SE, Silburn, SA, Sipila, SK, Sips, ACC, Solano, ER, Strauss, HR, Stuart, CI, Sun, HJ, Susts, TE, Teimane, AS, Tinguely, RA, Turner, MM, Olivares, PV, Rinati, GV, Virtanen, AJ, Walkden, NR, Maxwell, HW, Williams, JC, Wright, JC, Zabolockis, RJ, Zaitsev, FS, Fernandez, DZ, Zastrow, KD, and Zotta, VK
Abstract: The JET 2019-2020 scientific and technological programme exploited the results of years of concerted scientific and engineering work, including the ITER-like wall (ILW: Be wall and W divertor) installed in 2010, improved diagnostic capabilities now fully available, a major neutral beam injection upgrade providing record power in 2019-2020, and tested the technical and procedural preparation for safe operation with tritium. Research along three complementary axes yielded a wealth of new results. Firstly, the JET plasma programme delivered scenarios suitable for high fusion power and alpha particle (alpha) physics in the coming D-T campaign (DTE2), with record sustained neutron rates, as well as plasmas for clarifying the impact of isotope mass on plasma core, edge and plasma-wall interactions, and for ITER pre-fusion power operation. The efficacy of the newly installed shattered pellet injector for mitigating disruption forces and runaway electrons was demonstrated. Secondly, research on the consequences of long-term exposure to JET-ILW plasma was completed, with emphasis on wall damage and fuel retention, and with analyses of wall materials and dust particles that will help validate assumptions and codes for design and operation of ITER and DEMO. Thirdly, the nuclear technology programme aiming to deliver maximum technological return from operations in D, T and D-T benefited from the highest D-D neutron yield in years, securing results for validating radiation transport and activation codes, and nuclear data for ITER.
Published: 2022

2. First principles and integrated modelling achievements towards trustful fusion power predictions for JET and ITER

Author: Garcia, J., Dumont, R. J., Joly, J., Morales, J., Garzotti, L., Bache, T. W., Baranov, Y., Casson, F. J., Challis, C., Kirov, K., Mailloux, J., Saarelma, S., Nocente, M., Banon-Navarro, A., Goerler, T., Citrin, J., Ho, A., Gallart, D., Mantsinen, M., Abduallev, (Abduallev, S, ( 8, S., 42, ), Abhangi, (Abhangi, M, ( 8, M., 54, ), Abreu, (Abreu, P, ( 8, P., 60, ), Afanasev, (Afanasev, V, V)(, 8, 61, ), Afzal, (Afzal, M, 14, ), Aggarwal, (Aggarwal, Km, ( 8, K. M., 85, ), Ahlgren, (Ahlgren, T, ( 8, T., 106, ), Aho-Mantila, (Aho-Mantila, L, ( 8, L., 113, ), Aiba, (Aiba, N, ( 8, N., 73, ), Airila, (Airila, M, Alarcon, (Alarcon, T, 15, ), Albanese, (Albanese, R, ( 8, R., 18, ), Alegre, (Alegre, D, ( 8, D., 64, ), Aleiferis, (Aleiferis, S, 75, ), Alessi, (Alessi, E, ( 8, E., 50, ), Aleynikov, (Aleynikov, P, 62, ), Alkseev, (Alkseev, A, ( 8, A., 76, ), Allinson, (Allinson, M, Alper, (Alper, B, ( 8, B., Alves, (Alves, E, Ambrosino, (Ambrosino, G, ( 8, G., (Ambrosino, R, Amosov, (Amosov, V, 95, ), Sunden, (Sunden, Ea, Andersson)( 8, E., 26, ), Andrews, (Andrews, R, Angelone, (Angelone, M, 96, ), Anghel, (Anghel, M, 92, ), Angioni, (Angioni, C, ( 8, C., 68, ), Appel, (Appel, L, Appelbee, (Appelbee, C, Arena, Paolo Pietro, (Arena, P, 34, ), Ariola, (Ariola, M, Arshad, (Arshad, S, 45, ), Artaud, (Artaud, J, ( 8, J., Arter, (Arter, W, ( 8, W., Ash, (Ash, A, Ashikawa, (Ashikawa, N, ( 8 ), N., Aslanyan, (Aslanyan, V, 70, ), Asunta, (Asunta, O, ( 8, O., Asztalos, 9, (Asztalos, O, 114, ), Auriemma, (Auriemma, F, ( 8, F., 19, ), Austin, (Austin, Y, ( 8, Y., Avotina, (Avotina, L, 109, ), Axton, (Axton, M, Ayres, (Ayres, C, Baciero, (Baciero, A, Baiao, (Baiao, D, Balboa, (Balboa, I, I)(, 8, Balden, (Balden, M, Balshaw, (Balshaw, N, Bandaru, (Bandaru, Vk, ( 8, V. 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J., Varje, (Varje, J, Vartanian, 9, (Vartanian, S, Vasava, (Vasava, K, Vasilopoulou, (Vasilopoulou, T, Vecsei, (Vecsei, M, Vega, (Vega, J, Ventre, (Ventre, S, Verdoolaege, (Verdoolaege, G, Verona, (Verona, C, Rinati, (Rinati, Gv, Verona)( 8, G., Veshchev, (Veshchev, E, Vianello, (Vianello, N, Vicente, (Vicente, J, Viezzer, (Viezzer, E, Villari, (Villari, S, Villone, (Villone, F, Vincent, (Vincent, M, Vincenzi, (Vincenzi, P, Vinyar, (Vinyar, I, Viola, (Viola, B, Vitins, (Vitins, A, Vizvary, (Vizvary, Z, Vlad, (Vlad, M, Voitsekhovitch, (Voitsekhovitch, I, Voltolina, (Voltolina, D, Von, Toussaint, U (von Toussaint, Vondracek, (Vondracek, P, Vuksic, (Vuksic, M, Wakeling, (Wakeling, B, Waldon, (Waldon, C, Walkden, (Walkden, N, Walker, (Walker, R, (Walker, M, Walsh, (Walsh, M, Wang, (Wang, N, (Wang, E, Warder, (Warder, S, Warren, (Warren, R, Waterhouse, (Waterhouse, J, Watts, (Watts, C, Wauters, (Wauters, T, Webb, (Webb, M, Weckmann, (Weckmann, A, Weiland, (Weiland, J, (Weiland, M, Weisen, (Weisen, H, Weiszflog, (Weiszflog, M, Welch, (Welch, P, West, (West, A, Wheatley, (Wheatley, M, Wheeler, (Wheeler, S, Whitehead, (Whitehead, Am, Whittaker, (Whittaker, D, Widdowson, (Widdowson, Am, Wiesen, (Wiesen, S, Wilkie, (Wilkie, G, Williams, (Williams, J, Willoughby, (Willoughby, D, Wilson, (Wilson, J, (Wilson, I, (Wilson, Hr, Wischmeier, (Wischmeier, M, Withycombe, (Withycombe, A, Witts, (Witts, D, Wolfrum, (Wolfrum, E, Wood, (Wood, R, Woodley, (Woodley, R, (Woodley, C, Wray, (Wray, S, Wright, (Wright, Jc, (Wright, P, Wukitch, (Wukitch, S, Wynn, (Wynn, A, Xiang, (Xiang, L, (Xu, T, Xue, (Xue, Y, Yadikin, (Yadikin, D, Yakovenko, (Yakovenko, Y, Yanling, (Yanling, W, Yavorskij, (Yavorskij, V, Young, (Young, I, (Young, R, (Young, D, Zacks, (Zacks, J, Zagorski, (Zagorski, R, Zaitsev, (Zaitsev, Fs, ( 8, F. S., Zakharov, (Zakharov, L, Zanino, (Zanino, R, Zarins, (Zarins, A, (Zarins, R, Fernandez, (Fernandez, Dz, Zarzoso)( 8, D., Zastrow, (Zastrow, Kd, Zerbini, (Zerbini, M, Zhang, (Zhang, W, Zhou, (Zhou, Y, Zilli, (Zilli, E, Zocco, (Zocco, A, Zoita, (Zoita, V, Zoletnik, (Zoletnik, S, Zwingmann, (Zwingmann, W, Zychor, (Zychor, I, 71), Science and Technology of Nuclear Fusion, Garcia, J, Dumont, R, Joly, J, Morales, J, Garzotti, L, Bache, T, Baranov, Y, Casson, F, Challis, C, Kirov, K, Mailloux, J, Saarelma, S, Nocente, M, Banon-Navarro, A, Goerler, T, Citrin, J, Ho, A, Gallart, D, Mantsinen, M, Mariani, A, Garcia, J., Dumont, R. J., Joly, J., Morales, J., Garzotti, L., Bache, T. W., Baranov, Y., Casson, F. J., Challis, C., Kirov, K., Mailloux, J., Saarelma, S., Nocente, M., Banon-Navarro, A., Goerler, T., Citrin, J., Ho, A., Gallart, D., Formisano, A., Mantsinen, M., Dumont, Rj, Bache, Tw, Casson, Fj, Abduallev, S, Abhangi, M, Abreu, P, Afanasev, V, Afzal, M, Aggarwal, Km, Ahlgren, T, Aho-Mantila, L, Aiba, N, Airila, M, Alarcon, T, Albanese, R, Alegre, D, Aleiferis, S, Alessi, E, Aleynikov, P, Alkseev, A, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, Amosov, V, Sunden, Ea, Andrews, R, Angelone, M, Anghel, M, Angioni, C, Appel, L, Appelbee, C, Arena, P, Ariola, M, Arshad, S, Artaud, J, Arter, W, Ash, A, Ashikawa, N, Aslanyan, V, Asunta, O, Asztalos, O, Auriemma, F, Austin, Y, Avotina, L, Axton, M, Ayres, C, Baciero, A, Baiao, D, Balboa, I, Balden, M, Balshaw, N, Bandaru, Vk, Banks, J, Baranov, Yf, Barcellona, C, Barnard, T, Barnes, M, Barnsley, R, Wiechec, Ab, Orte, Lb, Baruzzo, M, Basiuk, V, Bassan, M, Bastow, R, Batista, A, Batistoni, P, Baumane, L, Bauvir, B, Baylor, L, Beaumont, P, Beckers, M, Beckett, B, Bekris, N, Beldishevski, M, Bell, K, Belli, F, Belonohy, E, Benayas, J, Bergsaker, H, Bernardo, J, Bernert, M, Berry, M, Bertalot, L, Besiliu, C, Betar, H, Beurskens, M, Bielecki, J, Biewer, T, Bilato, R, Biletskyi, O, Bilkova, P, Binda, F, Birkenmeier, G, Bizarro, Jp, Bjorkas, C, Blackburn, J, Blackman, Tr, Blanchard, P, Blatchford, P, Bobkov, V, Boboc, A, Bogar, O, Bohm, P, Bohm, T, Bolshakova, I, Bolzonella, T, Bonanomi, N, Boncagni, L, Bonfiglio, D, Bonnin, X, Boom, J, Borba, D, Borodin, D, Borodkina, I, Boulbe, C, Bourdelle, C, Bowden, M, Bowman, C, Boyce, T, Boyer, H, Bradnam, Sc, Braic, V, Bravanec, R, Breizman, B, Brennan, D, Breton, S, Brett, A, Brezinsek, S, Bright, M, Brix, M, Broeckx, W, Brombin, M, Broslawski, A, Brown, B, Brunetti, D, Bruno, E, Buch, J, Buchanan, J, Buckingham, R, Buckley, M, Bucolo, M, Budny, R, Bufferand, H, Buller, S, Bunting, P, Buratti, P, Burckhart, A, Burroughes, G, Buscarino, A, Busse, A, Butcher, D, Butler, B, Bykov, I, Cahyna, P, Calabro, G, Calacci, L, Callaghan, D, Callaghan, J, Calvo, I, Camenen, Y, Camp, P, Campling, Dc, Cannas, B, Capat, A, Carcangiu, S, Card, P, Cardinali, A, Carman, P, Carnevale, D, Carr, M, Carralero, D, Carraro, L, Carvalho, Bb, Carvalho, I, Carvalho, P, Carvalho, Dd, Castaldo, C, Catarino, N, Causa, F, Cavazzana, R, Cave-Ayland, K, Cavedon, M, Cecconello, M, Ceccuzzi, S, Cecil, E, Challis, Cd, Chandra, D, Chang, C, Chankin, A, Chapman, It, Chapman, B, Chapman, Sc, Chernyshova, M, Chiariello, A, Chitarin, G, Chmielewski, P, Chone, L, Ciraolo, G, Ciric, D, Clairet, F, Clark, M, Clark, E, Clarkson, R, Clay, R, Clements, C, Coad, Jp, Coates, P, Cobalt, A, Coccorese, V, Cocilovo, V, Coelho, R, Coenen, Jw, Coffey, I, Colas, L, Colling, B, Collins, S, Conka, D, Conroy, S, Conway, N, Coombs, D, Cooper, Sr, Corradino, C, Corre, Y, Corrigan, G, Coster, D, Craciunescu, T, Cramp, S, Crapper, C, Crisanti, F, Croci, G, Croft, D, Crombe, K, Cruz, N, Cseh, G, Cufar, A, Cullen, A, Curson, P, Curuia, M, Czarnecka, A, Czarski, T, Cziegler, I, Dabirikhah, H, Dal Molin, A, Dalgliesh, P, Dalley, S, Dankowski, J, Darrow, D, David, P, Davies, A, Davis, W, Dawson, K, Day, I, Day, C, De Bock, M, de Castro, A, De Dominici, G, de la Cal, E, de la Luna, E, De Masi, G, De Temmerman, G, De Tommasi, G, de Vries, P, Deane, J, Dejarnac, R, Del Sarto, D, Delabie, E, Demerdzhiev, V, Dempsey, A, den Harder, N, Dendy, Ro, Denis, J, Denner, P, Devaux, S, Devynck, P, Di Maio, F, Di Siena, A, Di Troia, C, Dickinson, D, Dinca, P, Dittmar, T, Dobrashian, J, Doerk, H, Doerner, Rp, Domptail, F, Donne, T, Dorling, Se, Douai, D, Dowson, S, Drenik, A, Dreval, M, Drewelow, P, Drews, P, Duckworth, P, Dumortier, P, Dunai, D, Dunne, M, Duran, I, Durodie, F, Dutta, P, Duval, Bp, Dux, R, Dylst, K, Edappala, Pv, Edwards, Am, Edwards, J, Eich, T, Eidietis, N, Eksaeva, A, Ellis, R, Ellwood, G, Elsmore, C, Emery, S, Enachescu, M, Ericsson, G, Eriksson, J, Eriksson, F, Eriksson, Lg, Ertmer, S, Esquembri, S, Esquisabel, Al, Esser, Hg, Ewart, G, Fable, E, Fagan, D, Faitsch, M, Falie, D, Fanni, A, Farahani, A, Fasoli, A, Faugeras, B, Fazinic, S, Felici, F, Felton, Rc, Feng, S, Fernades, A, Fernandes, H, Ferreira, J, Ferreira, Dr, Ferro, G, Fessey, Ja, Ficker, O, Field, A, Fietz, S, Figini, L, Figueiredo, J, Figueiredo, A, Fil, N, Finburg, P, Fischer, U, Fittill, L, Fitzgerald, M, Flammini, D, Flanagan, J, Flinders, K, Foley, S, Fonnesu, N, Fontdecaba, Jm, Formisano, A, Forsythe, L, Fortuna, L, Fransson, E, Frasca, M, Frassinetti, L, Freisinger, M, Fresa, R, Fridstrom, R, Frigione, D, Fuchs, V, Fusco, V, Futatani, S, Gal, K, Galassi, D, Galazka, K, Galeani, S, Galvao, R, Gao, Y, Garcia-Carrasco, A, Garcia-Munoz, M, Gardener, M, Gaspar, J, Gaudio, P, Gear, D, Gebhart, T, Gee, S, Geiger, B, Gelfusa, M, George, R, Gerasimov, S, Gervasini, G, Gethins, M, Ghani, Z, Ghate, M, Gherendi, M, Ghezzi, F, Giacalone, Jc, Giacomelli, L, Giacometti, G, Gibson, K, Giegerich, T, Gil, L, Gilbert, Mr, Gin, D, Giovannozzi, E, Giroud, C, Gloggler, S, Goff, J, Gohil, P, Goloborod'Ko, V, Gomes, R, Goncalves, B, Goniche, M, Goodyear, A, Gorini, G, Gorler, T, Goulding, R, Goussarov, A, Graham, B, Graves, Jp, Greuner, H, Grierson, B, Griffiths, J, Griph, S, Grist, D, Groth, M, Grove, R, Gruca, M, Guard, D, Guerard, C, Guillemaut, C, Guirlet, R, Gulati, S, Gurl, C, Gutierrez-Milla, A, Utoh, Hh, Hackett, L, Hacquin, S, Hager, R, Hakola, A, Halitovs, M, Hall, S, Hallworth-Cook, S, Ham, C, Hamed, M, Hamilton, N, Hamlyn-Harris, C, Hammond, K, Hancu, G, Harrison, J, Harting, D, Hasenbeck, F, Hatano, Y, Hatch, Dr, Haupt, T, Hawes, J, Hawkes, Nc, Hawkins, J, Hawkins, P, Hazel, S, Heesterman, P, Heinola, K, Hellesen, C, Hellsten, T, Helou, W, Hemming, O, Hender, Tc, Henderson, S, Henderson, M, Henriques, R, Hepple, D, Herfindal, J, Hermon, G, Hidalgo, C, Higginson, W, Highcock, Eg, Hillesheim, J, Hillis, D, Hizanidis, K, Hjalmarsson, A, Hobirk, J, Hogben, Cha, Hogeweij, Gmd, Hollingsworth, A, Hollis, S, Holzl, M, Honore, Jj, Hook, M, Hopley, D, Horacek, J, Hornung, G, Horton, A, Horton, Ld, Horvath, L, Hotchin, Sp, Howell, R, Hubbard, A, Huber, A, Huber, V, Huddleston, Tm, Hughes, M, Hughes, J, Huijsmans, Gta, Huynh, P, Hynes, A, Igaune, I, Iglesias, D, Imazawa, N, Imrisek, M, Incelli, M, Innocente, P, Ivanova-Stanik, I, Ivings, E, Jachmich, S, Jackson, A, Jackson, T, Jacquet, P, Jansons, J, Jaulmes, F, Jednorog, S, Jenkins, I, Jepu, I, Johnson, T, Johnson, R, Johnston, J, Joita, L, Jonasson, E, Jones, T, Jones, C, Jones, L, Jones, G, Jones, N, Juvonen, M, Hoshino, Kk, Kallenbach, A, Kalsey, M, Kaltiaisenaho, T, Kamiya, K, Kaniewski, J, Kantor, A, Kappatou, A, Karhunen, J, Karkinsky, D, Kaufman, M, Kaveney, G, Kazakov, Y, Kazantzidis, V, Keeling, Dl, Keenan, Fp, Kempenaars, M, Kent, O, Kent, J, Keogh, K, Khilkevich, E, Kim, Ht, King, R, King, D, Kinna, Dj, Kiptily, V, Kirk, A, Kirschner, A, Kizane, G, Klas, M, Klepper, C, Klix, A, Knight, M, Knight, P, Knipe, S, Knott, S, Kobuchi, T, Kochl, F, Kocsis, G, Kodeli, I, Koechl, F, Kogut, D, Koivuranta, S, Kolesnichenko, Y, Kollo, Z, Kominis, Y, Koppen, M, Korolczuk, S, Kos, B, Koslowski, Hr, Kotschenreuther, M, Koubiti, M, Kovaldins, R, Kovanda, O, Kowalska-Strzeciwilk, E, Krasilnikov, A, Krasilnikov, V, Krawczyk, N, Kresina, M, Krieger, K, Krivska, A, Kruezi, U, Ksiazek, I, Kukushkin, A, Kundu, A, Kurki-Suonio, T, Kwak, S, Kwon, Oj, Laguardia, L, Lahtinen, A, Laing, A, Lalousis, P, Lam, N, Lamb, C, Lambertz, Ht, Lang, Pt, Lanthaler, S, Neto, El, Laszynska, E, Lawless, R, Lawson, Kd, Lazaros, A, Lazzaro, E, Leach, R, Learoyd, G, Leerink, S, Lefebvre, X, Leggate, Hj, Lehmann, J, Lehnen, M, Leichauer, P, Leichtle, D, Leipold, F, Lengar, I, Lennholm, M, Lepiavko, B, Leppanen, J, Lerche, E, Lescinskis, A, Lescinskis, B, Lesnoj, S, Leyland, M, Leysen, W, Li, Y, Li, L, Liang, Y, Likonen, J, Linke, J, Linsmeier, C, Lipschultz, B, Litaudon, X, Liu, G, Lloyd, B, Lo Schiavo, Vp, Loarer, T, Loarte, A, Lomanowski, B, Lomas, Pj, Lonnroth, J, Lopez, Jm, Lorenzini, R, Losada, U, Loughlin, M, Lowry, C, Luce, T, Lucock, R, Lukin, A, Luna, C, Lungaroni, M, Lungu, Cp, Lungu, M, Lunniss, A, Lunt, T, Lupelli, I, Lutsenko, V, Lyssoivan, A, Macheta, P, Macusova, E, Magesh, B, Maggi, C, Maggiora, R, Mahesan, S, Maier, H, Maingi, R, Makwana, R, Malaquias, A, Malinowski, K, Malizia, A, Manas, P, Manduchi, G, Manso, Me, Mantica, P, Manzanares, A, Maquet, P, Marandet, Y, Marcenko, N, Marchetto, C, Marchuk, O, Marconato, N, Marin, M, Marinelli, M, Marinucci, M, Markovic, T, Marocco, D, Marot, L, Marsh, J, Martin, A, de Aguilera, Am, Martin-Solis, Jr, Martone, R, Martynova, Y, Maruyama, S, Maslov, M, Matejcik, S, Mattei, M, Matthews, Gf, Matveev, D, Matveeva, E, Mauriya, A, Maviglia, F, May-Smith, T, Mayer, M, Mayoral, Ml, Mazon, D, Mazzotta, C, Mcadams, R, Mccarthy, Pj, Mcclements, Kg, Mccormack, O, Mccullen, Pa, Mcdonald, D, Mchardy, M, Mckean, R, Mckehon, J, Mcnamee, L, Meadowcroft, C, Meakins, A, Medley, S, Meigh, S, Meigs, Ag, Meisl, G, Meiter, S, Meitner, S, Meneses, L, Menmuir, S, Mergia, K, Merle, A, Merriman, P, Mertens, P, Meshchaninov, S, Messiaen, A, Meyer, H, Michling, R, Milanesio, D, Militello, F, Militello-Asp, E, Milocco, A, Miloshevsky, G, Mink, F, Minucci, S, Miron, I, Mistry, S, Miyoshi, Y, Mlynar, J, Moiseenko, V, Monaghan, P, Monakhov, I, Moon, S, Mooney, R, Moradi, S, Moran, J, Mordijck, S, Moreira, L, Moro, F, Morris, J, Moser, L, Mosher, S, Moulton, D, Mrowetz, T, Muir, A, Muraglia, M, Murari, A, Muraro, A, Murphy, S, Muscat, P, Muthusonai, N, Myers, C, Asakura, Nn, N'Konga, B, Nabais, F, Naish, R, Naish, J, Nakano, T, Napoli, F, Nardon, E, Naulin, V, Nave, Mff, Nedzelskiy, I, Nemtsev, G, Nesenevich, V, Nespoli, F, Neto, A, Neu, R, Neverov, V, Newman, M, Ng, S, Nicassio, M, Nielsen, Ah, Nina, D, Nishijima, D, Noble, C, Nobs, Cr, Nodwell, D, Nordlund, K, Nordman, H, Normanton, R, Noterdaeme, Jm, Nowak, S, Nunes, I, O'Gorman, T, O'Mullane, M, Oberkofler, M, Oberparleiter, M, Odupitan, T, Ogawa, Mt, Okabayashi, M, Oliver, H, Olney, R, Omoregie, L, Ongena, J, Orsitto, F, Orszagh, J, Osborne, T, Otin, R, Owen, A, Owen, T, Paccagnella, R, Packer, Lw, Pajuste, E, Pamela, S, Panja, S, Papp, P, Papp, G, Parail, V, Pardanaud, C, Diaz, Fp, Parsloe, A, Parsons, N, Parsons, M, Pasqualotto, R, Passeri, M, Patel, A, Pathak, S, Patten, H, Pau, A, Pautasso, G, Pavlichenko, R, Pavone, A, Pawelec, E, Soldan, Cp, Peackoc, A, Pehkonen, Sp, Peluso, E, Penot, C, Penzo, J, Pepperell, K, Pereira, R, Cippo, Ep, von Thun, Cp, Pericoli, V, Peruzzo, S, Peterka, M, Petersson, P, Petravich, G, Petre, A, Petrzilka, V, Philipps, V, Pigatto, L, Pillon, M, Pinches, S, Pintsuk, G, Piovesan, P, de Sa, Wp, dos Reis, Ap, Piron, L, Piron, C, Pironti, A, Pisano, F, Pitts, R, Plyusnin, V, Poli, Fm, Pomaro, N, Pompilian, Og, Pool, P, Popovichev, S, Poradzinski, M, Porfiri, Mt, Porosnicu, C, Porton, M, Possnert, G, Potzel, S, Poulipoulis, G, Powell, T, Prajapati, V, Prakash, R, Predebon, I, Prestopino, G, Price, D, Price, M, Price, R, Primetzhofer, D, Prior, P, Pucella, G, Puglia, P, Puiatti, Me, Purahoo, K, Pusztai, I, Putterich, T, Rachlew, E, Rack, M, Ragona, R, Rainford, M, Raj, P, Rakha, A, Ramogida, G, Ranjan, S, Rapson, Cj, Rasmussen, D, Rasmussen, Jj, Rathod, K, Ratta, G, Ratynskaia, S, Ravera, G, Rebai, M, Reed, A, Refy, D, Regana, J, Reich, M, Reid, N, Reimold, F, Reinhart, M, Reinke, M, Reiser, D, Rendell, D, Reux, C, Cortes, Sdar, Reynolds, S, Ricci, D, Richiusa, M, Rigamonti, D, Rimini, Fg, Risner, J, Riva, M, Rivero-Rodriguez, J, Roach, C, Robins, R, Robinson, S, Robson, D, Rodionov, R, Rodrigues, P, Rodriguez, J, Rohde, V, Romanelli, M, Romanelli, F, Romanelli, S, Romazanov, J, Rowe, S, Rubel, M, Rubinacci, G, Rubino, G, Ruchko, L, Ruset, C, Rzadkiewicz, J, Sabot, R, Saez, X, Safi, E, Sahlberg, A, Saibene, G, Saleem, M, Salewski, M, Salmi, A, Salmon, R, Salzedas, F, Samm, U, Sandiford, D, Santa, P, Santala, Mik, Santos, B, Santucci, A, Sartori, F, Sartori, R, Sauter, O, Scannell, R, Schluck, F, Schlummer, T, Schmid, K, Schmuck, S, Schopf, K, Schweinzer, J, Schworer, D, Scott, Sd, Sergienko, G, Sertoli, M, Shabbir, A, Sharapov, Se, Shaw, A, Sheikh, H, Shepherd, A, Shevelev, A, Shiraki, D, Shumack, A, Sias, G, Sibbald, M, Sieglin, B, Silburn, S, Silva, J, Silva, A, Silva, C, Silvagni, D, Simmons, P, Simpson, J, Sinha, A, Sipila, Sk, Sips, Acc, Siren, P, Sirinelli, A, Sjostrand, H, Skiba, M, Skilton, R, Skvara, V, Slade, B, Smith, R, Smith, P, Smith, Sf, Snoj, L, Soare, S, Solano, Er, Somers, A, Sommariva, C, Sonato, P, Sos, M, Sousa, J, Sozzi, C, Spagnolo, S, Sparapani, P, Spelzini, T, Spineanu, F, Sprada, D, Sridhar, S, Stables, G, Stallard, J, Stamatelatos, I, Stamp, Mf, Stan-Sion, C, Stancar, Z, Staniec, P, Stankunas, G, Stano, M, Stavrou, C, Stefanikova, E, Stepanov, I, Stephen, Av, Stephen, M, Stephens, J, Stevens, B, Stober, J, Stokes, C, Strachan, J, Strand, P, Strauss, Hr, Strom, P, Studholme, W, Subba, F, Suchkov, E, Summers, Hp, Sun, H, Sutton, N, Svensson, J, Sytnykov, D, Szabolics, T, Szepesi, G, Suzuki, Tt, Tabares, F, Tadic, T, Tal, B, Tala, T, Taliercio, C, Tallargio, A, Tanaka, K, Tang, W, Tardocchi, M, Tatali, R, Taylor, D, Tegnered, D, Telesca, G, Teplova, N, Teplukhina, A, Terranova, D, Terry, C, Testa, D, Tholerus, E, Thomas, J, Thompson, Vk, Thornton, A, Tierens, W, Tiseanu, I, Tojo, H, Tokitani, M, Tolias, P, Tomes, M, Trimble, P, Tripsky, M, Tsalas, M, Tsavalas, P, Tskhakaya, D, Jun, Dt, Turner, I, Turner, Mm, Turnyanskiy, M, Tvalashvili, G, Tyshchenko, M, Uccello, A, Uljanovs, J, Urano, H, Urban, A, Urbanczyk, G, Uytdenhouwen, I, Vadgama, A, Valcarcel, D, Vale, R, Valentinuzzi, M, Valerii, K, Valisa, M, Olivares, Pv, Valovic, M, Van Eester, D, Van Renterghem, W, van Rooij, Gj, Varje, J, Vartanian, S, Vasava, K, Vasilopoulou, T, Vecsei, M, Vega, J, Ventre, S, Verdoolaege, G, Verona, C, Rinati, Gv, Veshchev, E, Vianello, N, Vicente, J, Viezzer, E, Villari, S, Villone, F, Vincent, M, Vincenzi, P, Vinyar, I, Viola, B, Vitins, A, Vizvary, Z, Vlad, M, Voitsekhovitch, I, Voltolina, D, von Toussaint, U, Vondracek, P, Vuksic, M, Wakeling, B, Waldon, C, Walkden, N, Walker, R, Walker, M, Walsh, M, Wang, N, Wang, E, Warder, S, Warren, R, Waterhouse, J, Watts, C, Wauters, T, Webb, M, Weckmann, A, Weiland, J, Weiland, M, Weisen, H, Weiszflog, M, Welch, P, West, A, Wheatley, M, Wheeler, S, Whitehead, Am, Whittaker, D, Widdowson, Am, Wiesen, S, Wilkie, G, Williams, J, Willoughby, D, Wilson, J, Wilson, I, Wilson, Hr, Wischmeier, M, Withycombe, A, Witts, D, Wolfrum, E, Wood, R, Woodley, R, Woodley, C, Wray, S, Wright, Jc, Wright, P, Wukitch, S, Wynn, A, Xiang, L, Xu, T, Xue, Y, Yadikin, D, Yakovenko, Y, Yanling, W, Yavorskij, V, Young, I, Young, R, Young, D, Zacks, J, Zagorski, R, Zaitsev, F, Zakharov, L, Zanino, R, Zarins, A, Zarins, R, Fernandez, Dz, Zastrow, Kd, Zerbini, M, Zhang, W, Zhou, Y, Zilli, E, Zocco, A, Zoita, V, Zoletnik, S, Zwingmann, W, Zychor, I, and JET Contributors
Subjects: Physics, Nuclear and High Energy Physics, Fusion, Jet (fluid), Maximum power principle, Nuclear engineering, Context (language use), Plasma, Fusion power, Condensed Matter Physics, 01 natural sciences, 7. Clean energy, ICRH, Charged particle, 010305 fluids & plasmas, JET, transport, TRANSPORT, Physics::Plasma Physics, Beta (plasma physics), 0103 physical sciences, 010306 general physics
Abstract: Predictability of burning plasmas is a key issue for designing and building credible future fusion devices. In this context, an important effort of physics understanding and guidance is being carried out in parallel to the on-going JET experimental campaigns in H, D and T by performing analyses and modelling towards an improvement of the understanding of DT physics for the optimization of the JET-DT neutron yield and fusion born alpha particle physics. Extrapolations to JET-DT from recent experiments using the maximum power available have been performed including some of the most sophisticated codes and a broad selection of models. There is a general agreement that 11-15MW of fusion power can be expected in DT for the hybrid and baseline scenarios. On the other hand, in high beta, torque and fast ion fraction conditions, isotope effects could be favourable leading to higher fusion yield. It is shown that alpha particles related physics, such as TAE destabilization or fusion power electron heating, could be studied in ITER relevant JET-DT plasmas.
Published: 2019
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3. Temporal analysis and stimulus fluctuation in listeners with normal and impaired hearing.

Author: Hall JW III, Grose JH, Buss E, and Hatch DR
Abstract: The first experiment investigated the effects of mild to moderate sensorineural hearing impairment on temporal analysis for noise stimuli of varying bandwidth. Tasks of temporal gap detection, amplitude modulation (AM) detection, and AM discrimination were examined. Relatively high levels of stimulation were used in order to reduce the possibility that the results of the listeners with hearing impairment would be influenced strongly by audibility. A general summary of results was that there was relatively great interlistener variation among the listeners with hearing impairment, with most listeners showing normal performance and some showing degraded performance, regardless of the bandwidth of the stimulus carrying the temporal information. A second experiment investigated the hypothesis that listeners with sensorineural hearing impairment might have poor gap detection due to loudness recruitment. Here, gap markers were presented at levels where loudness growth was steeper for the listeners with hearing impairment than for the listeners with normal hearing. Although gap detection was sometimes poorer in listeners with hearing impairment than in listeners with normal hearing, there was no clear relation between gap detection performance and loudness recruitment in listeners with mild to moderate sensorineural hearing impairment. [ABSTRACT FROM AUTHOR]
Published: 1998
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4. Biometric Sensor Addresses Infant Hypoxia.

Author: Hatch, Dr. Guy M.
Subjects: BIOMETRIC identification, HYPOXEMIA, DETECTORS
Published: 2017

5. Subdominant Modes in Zonal-Flow-Regulated Turbulence

Author: Hatch, DR
Published: 2014
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6. Adaptive learning for disruption prediction in non-stationary conditions

Author: Murari, A., Lungaroni, M., Gelfusa, M., Peluso, E., Vega, J., Abduallev, S., Abhangi, M., Abreu, P., Afanasev, V, Afzal, M., Aggarwal, K. M., Ahlgren, T., Aho-Mantila, L., Aiba, N., Airila, M., Alarcon, T., Albanese, R., Alegre, D., Aleiferis, S., Alessi, E., Aleynikov, P., Alkseev, A., Allinson, M., Alper, B., Alves, E., Ambrosino, G., Ambrosino, R., Amosov, V, Sunden, E. Andersson, Andrews, R., Angelone, M., Anghel, M., Angioni, C., Appel, L., Appelbee, C., Arena, P., Ariola, M., Arshad, S., Artaud, J., Arter, W., Ash, A., Ashikawa, N., Aslanyan, V, Asunta, O., Asztalos, O., Auriemma, F., Austin, Y., Avotina, L., Axton, M., Ayres, C., Baciero, A., Baiao, D., Balboa, I, Balden, M., Balshaw, N., Bandaru, V. K., Banks, J., Baranov, Y. F., Barcellona, C., Barnard, T., Barnes, M., Barnsley, R., Wiechec, A. Baron, Orte, L. Barrera, Baruzzo, M., Basiuk, V, Bassan, M., Bastow, R., Batista, A., Batistoni, P., Baumane, L., Bauvir, B., Baylor, L., Beaumont, P. S., Beckers, M., Beckett, B., Bekris, N., Beldishevski, M., Bell, K., Belli, F., Belonohy, E., Benayas, J., Bergsaker, H., Bernardo, J., Bernert, M., Berry, M., Bertalot, L., Besiliu, C., Betar, H., Beurskens, M., Bielecki, J., Biewer, T., Bilato, R., Biletskyi, O., Bilkova, P., Binda, F., Birkenmeier, G., Bizarro, J. P. S., Bjorkas, C., Blackburn, J., Blackman, T. R., Blanchard, P., Blatchford, P., Bobkov, V, Boboc, A., Bogar, O., Bohm, P., Bohm, T., Bolshakova, I, Bolzonella, T., Bonanomi, N., Boncagni, L., Bonfiglio, D., Bonnin, X., Boom, J., Borba, D., Borodin, D., Borodkina, I, Boulbe, C., Bourdelle, C., Bowden, M., Bowman, C., Boyce, T., Boyer, H., Bradnam, S. C., Braic, V, Bravanec, R., Breizman, B., Brennan, D., Breton, S., Brett, A., Brezinsek, S., Bright, M., Brix, M., Broeckx, W., Brombin, M., Broslawski, A., Brown, B., Brunetti, D., Bruno, E., Buch, J., Buchanan, J., Buckingham, R., Buckley, M., Bucolo, M., Budny, R., Bufferand, H., Buller, S., Bunting, P., Buratti, P., Burckhart, A., Burroughes, G., Buscarino, A., Busse, A., Butcher, D., Butler, B., Bykov, I, Cahyna, P., Calabro, G., Calacci, L., Callaghan, D., Callaghan, J., Calvo, I, Camenen, Y., Camp, P., Campling, D. C., Cannas, B., Capat, A., Carcangiu, S., Card, P., Cardinali, A., Carman, P., Carnevale, D., Carr, M., Carralero, D., Carraro, L., Carvalho, B. B., Carvalho, I, Carvalho, P., Carvalho, D. D., Casson, F. J., Castaldo, C., Catarino, N., Causa, F., Cavazzana, R., Cave-Ayland, K., Cavedon, M., Cecconello, M., Ceccuzzi, S., Cecil, E., Challis, C. D., Chandra, D., Chang, C. S., Chankin, A., Chapman, I. T., Chapman, B., Chapman, S. C., Chernyshova, M., Chiariello, A., Chitarin, G., Chmielewski, P., Chone, L., Ciraolo, G., Ciric, D., Citrin, J., Clairet, F., Clark, M., Clark, E., Clarkson, R., Clay, R., Clements, C., Coad, J. P., Coates, P., Cobalt, A., Coccorese, V, Cocilovo, V, Coelho, R., Coenen, J. W., Coffey, I, Colas, L., Colling, B., Collins, S., Conka, D., Conroy, S., Conway, N., Coombs, D., Cooper, S. R., Corradino, C., Corre, Y., Corrigan, G., Coster, D., Craciunescu, T., Cramp, S., Crapper, C., Crisanti, F., Croci, G., Croft, D., Crombe, K., Cruz, N., Cseh, G., Cufar, A., Cullen, A., Curson, P., Curuia, M., Czarnecka, A., Czarski, T., Cziegler, I, Dabirikhah, H., Dal Molin, A., Dalgliesh, P., Dalley, S., Dankowski, J., Darrow, D., David, P., Davies, A., Davis, W., Dawson, K., Day, I, Day, C., De Bock, M., de Castro, A., De Dominici, G., de la Cal, E., de la Luna, E., De Masi, G., De Temmerman, G., De Tommasi, G., de Vries, P., Deane, J., Dejarnac, R., Del Sarto, D., Delabie, E., Demerdzhiev, V, Dempsey, A., den Harder, N., Dendy, R. O., Denis, J., Denner, P., Devaux, S., Devynck, P., Di Maio, F., Di Siena, A., Di Troia, C., Dickinson, D., Dinca, P., Dittmar, T., Dobrashian, J., Doerk, H., Doerner, R. P., Domptail, F., Donne, T., Dorling, S. E., Douai, D., Dowson, S., Drenik, A., Dreval, M., Drewelow, P., Drews, P., Duckworth, Ph, Dumont, R., Dumortier, P., Dunai, D., Dunne, M., Duran, I, Durodie, F., Dutta, P., Duval, B. P., Dux, R., Dylst, K., Edappala, P., V, Edwards, A. M., Edwards, J. S., Eich, Th, Eidietis, N., Eksaeva, A., Ellis, R., Ellwood, G., Elsmore, C., Emery, S., Enachescu, M., Ericsson, G., Eriksson, J., Eriksson, F., Eriksson, L. G., Ertmer, S., Esquembri, S., Esquisabel, A. L., Esser, H. G., Ewart, G., Fable, E., Fagan, D., Faitsch, M., Falie, D., Fanni, A., Farahani, A., Fasoli, A., Faugeras, B., Fazinic, S., Felici, F., Felton, R. C., Feng, S., Fernades, A., Fernandes, H., Ferreira, J., Ferreira, D. R., Ferro, G., Fessey, J. A., Ficker, O., Field, A., Fietz, S., Figini, L., Figueiredo, J., Figueiredo, A., Fil, N., Finburg, P., Fischer, U., Fittill, L., Fitzgerald, M., Flammini, D., Flanagan, J., Flinders, K., Foley, S., Fonnesu, N., Fontdecaba, J. M., Formisano, A., Forsythe, L., Fortuna, L., Fransson, E., Frasca, M., Frassinetti, L., Freisinger, M., Fresa, R., Fridstrom, R., Frigione, D., Fuchs, V, Fusco, V, Futatani, S., Gal, K., Galassi, D., Galazka, K., Galeani, S., Gallart, D., Galvao, R., Gao, Y., Garcia, J., Garcia-Carrasco, A., Garcia-Munoz, M., Gardener, M., Garzotti, L., Gaspar, J., Gaudio, P., Gear, D., Gebhart, T., Gee, S., Geiger, B., George, R., Gerasimov, S., Gervasini, G., Gethins, M., Ghani, Z., Ghate, M., Gherendi, M., Ghezzi, F., Giacalone, J. C., Giacomelli, L., Giacometti, G., Gibson, K., Giegerich, T., Gil, L., Gilbert, M. R., Gin, D., Giovannozzi, E., Giroud, C., Gloeggler, S., Goff, J., Gohil, P., Goloborod'Ko, V, Gomes, R., Goncalves, B., Goniche, M., Goodyear, A., Gorini, G., Goerler, T., Goulding, R., Goussarov, A., Graham, B., Graves, J. P., Greuner, H., Grierson, B., Griffiths, J., Griph, S., Grist, D., Groth, M., Grove, R., Gruca, M., Guard, D., Guerard, C., Guillemaut, C., Guirlet, R., Gulati, S., Gurl, C., Gutierrez-Milla, A., Utoh, H. H., Hackett, L., Hacquin, S., Hager, R., Hakola, A., Halitovs, M., Hall, S., Hallworth-Cook, S., Ham, C., Hamed, M., Hamilton, N., Hamlyn-Harris, C., Hammond, K., Hancu, G., Harrison, J., Harting, D., Hasenbeck, F., Hatano, Y., Hatch, D. R., Haupt, T., Hawes, J., Hawkes, N. C., Hawkins, J., Hawkins, P., Hazel, S., Heesterman, P., Heinola, K., Hellesen, C., Hellsten, T., Helou, W., Hemming, O., Hender, T. C., Henderson, S. S., Henderson, M., Henriques, R., Hepple, D., Herfindal, J., Hermon, G., Hidalgo, C., Higginson, W., Highcock, E. G., Hillesheim, J., Hillis, D., Hizanidis, K., Hjalmarsson, A., Ho, A., Hobirk, J., Hogben, C. H. A., Hogeweij, G. M. D., Hollingsworth, A., Hollis, S., Hoelzl, M., Honore, J-J, Hook, M., Hopley, D., Horacek, J., Hornung, G., Horton, A., Horton, L. D., Horvath, L., Hotchin, S. P., Howell, R., Hubbard, A., Huber, A., Huber, V, Huddleston, T. M., Hughes, M., Hughes, J., Huijsmans, G. T. A., Huynh, P., Hynes, A., Igaune, I., Iglesias, D., Imazawa, N., Imrisek, M., Incelli, M., Innocente, P., Ivanova-Stanik, I., Ivings, E., Jachmich, S., Jackson, A., Jackson, T., Jacquet, P., Jansons, J., Jaulmes, F., Jednorog, S., Jenkins, I, Jepu, I, Johnson, T., Johnson, R., Johnston, J., Joita, L., Joly, J., Jonasson, E., Jones, T., Jones, C., Jones, L., Jones, G., Jones, N., Juvonen, M., Hoshino, K. K., Kallenbach, A., Kalsey, M., Kaltiaisenaho, T., Kamiya, K., Kaniewski, J., Kantor, A., Kappatou, A., Karhunen, J., Karkinsky, D., Kaufman, M., Kaveney, G., Kazakov, Y., Kazantzidis, V, Keeling, D. L., Keenan, F. P., Kempenaars, M., Kent, O., Kent, J., Keogh, K., Khilkevich, E., Kim, H-T, Kim, H. T., King, R., King, D., Kinna, D. J., Kiptily, V, Kirk, A., Kirov, K., Kirschner, A., Kizane, G., Klas, M., Klepper, C., Klix, A., Knight, M., Knight, P., Knipe, S., Knott, S., Kobuchi, T., Kochl, F., Kocsis, G., Kodeli, I, Koechl, F., Kogut, D., Koivuranta, S., Kolesnichenko, Y., Kollo, Z., Kominis, Y., Koeppen, M., Korolczuk, S., Kos, B., Koslowski, H. R., Kotschenreuther, M., Koubiti, M., Kovaldins, R., Kovanda, O., Kowalska-Strzeciwilk, E., Krasilnikov, A., Krasilnikov, V, Krawczyk, N., Kresina, M., Krieger, K., Krivska, A., Kruezi, U., Ksiazek, I, Kukushkin, A., Kundu, A., Kurki-Suonio, T., Kwak, S., Kwon, O. J., Laguardia, L., Lahtinen, A., Laing, A., Lalousis, P., Lam, N., Lamb, C., Lambertz, H. T., Lang, P. T., Lanthaler, S., Neto, E. Lascas, Laszynska, E., Lawless, R., Lawson, K. D., Lazaros, A., Lazzaro, E., Leach, R., Learoyd, G., Leerink, S., Lefebvre, X., Leggate, H. J., Lehmann, J., Lehnen, M., Leichauer, P., Leichtle, D., Leipold, F., Lengar, I, Lennholm, M., Lepiavko, B., Leppanen, J., Lerche, E., Lescinskis, A., Lescinskis, B., Lesnoj, S., Leyland, M., Leysen, W., Li, Y., Li, L., Liang, Y., Likonen, J., Linke, J., Linsmeier, Ch, Lipschultz, B., Litaudon, X., Liu, G., Lloyd, B., Lo Schiavo, V. P., Loarer, T., Loarte, A., Lomanowski, B., Lomas, P. J., Lonnroth, J., Lopez, J. M., Lorenzini, R., Losada, U., Loughlin, M., Lowry, C., Luce, T., Lucock, R., Lukin, A., Luna, C., Lungu, C. P., Lungu, M., Lunniss, A., Lunt, T., Lupelli, I, Lutsenko, V, Lyssoivan, A., Macheta, P., Macusova, E., Magesh, B., Maggi, C., Maggiora, R., Mahesan, S., Maier, H., Mailloux, J., Maingi, R., Makwana, R., Malaquias, A., Malinowski, K., Malizia, A., Manas, P., Manduchi, G., Manso, M. E., Mantica, P., Mantsinen, M., Manzanares, A., Maquet, Ph, Marandet, Y., Marcenko, N., Marchetto, C., Marchuk, O., Marconato, N., Mariani, A., Marin, M., Marinelli, M., Marinucci, M., Markovic, T., Marocco, D., Marot, L., Marsh, J., Martin, A., Martin de Aguilera, A., Martin-Solis, J. R., Martone, R., Martynova, Y., Maruyama, S., Maslov, M., Matejcik, S., Mattei, M., Matthews, G. F., Matveev, D., Matveeva, E., Mauriya, A., Maviglia, F., May-Smith, T., Mayer, M., Mayoral, M. L., Mazon, D., Mazzotta, C., Mcadams, R., Mccarthy, P. J., Mcclements, K. G., Mccormack, O., Mccullen, P. A., Mcdonald, D., Mchardy, M., Mckean, R., Mckehon, J., Mcnamee, L., Meadowcroft, C., Meakins, A., Medley, S., Meigh, S., Meigs, A. G., Meisl, G., Meiter, S., Meitner, S., Meneses, L., Menmuir, S., Mergia, K., Merle, A., Merriman, P., Mertens, Ph, Meshchaninov, S., Messiaen, A., Meyer, H., Michling, R., Milanesio, D., Militello, F., Militello-Asp, E., Milocco, A., Miloshevsky, G., Mink, F., Minucci, S., Miron, I, Mistry, S., Miyoshi, Y., Mlynar, J., Moiseenko, V, Monaghan, P., Monakhov, I, Moon, S., Mooney, R., Moradi, S., Morales, J., Moran, J., Mordijck, S., Moreira, L., Moro, F., Morris, J., Moser, L., Mosher, S., Moulton, D., Mrowetz, T., Muir, A., Muraglia, M., Muraro, A., Murphy, S., Muscat, P., Muthusonai, N., Myers, C., Asakura, N. N., N'Konga, B., Nabais, F., Naish, R., Naish, J., Nakano, T., Napoli, F., Nardon, E., Naulin, V, Nave, M. F. F., Nedzelskiy, I, Nemtsev, G., Nesenevich, V, Nespoli, F., Neto, A., Neu, R., Neverov, V. S., Newman, M., Ng, S., Nicassio, M., Nielsen, A. H., Nina, D., Nishijima, D., Noble, C., Nobs, C. R., Nocente, M., Nodwell, D., Nordlund, K., Nordman, H., Normanton, R., Noterdaeme, J. M., Nowak, S., Nunes, I, O'Gorman, T., O'Mullane, M., Oberkofler, M., Oberparleiter, M., Odupitan, T., Ogawa, M. T., Okabayashi, M., Oliver, H., Olney, R., Omoregie, L., Ongena, J., Orsitto, F., Orszagh, J., Osborne, T., Otin, R., Owen, A., Owen, T., Paccagnella, R., Packer, L. W., Pajuste, E., Pamela, S., Panja, S., Papp, P., Papp, G., Parail, V, Pardanaud, C., Diaz, F. Parra, Parsloe, A., Parsons, N., Parsons, M., Pasqualotto, R., Passeri, M., Patel, A., Pathak, S., Patten, H., Pau, A., Pautasso, G., Pavlichenko, R., Pavone, A., Pawelec, E., Soldan, C. Paz, Peackoc, A., Pehkonen, S-P, Penot, C., Penzo, J., Pepperell, K., Pereira, R., Cippo, E. Perelli, von Thun, C. Perez, Pericoli, V, Peruzzo, S., Peterka, M., Petersson, P., Petravich, G., Petre, A., Petrzilka, V, Philipps, V, Pigatto, L., Pillon, M., Pinches, S., Pintsuk, G., Piovesan, P., de Sa, W. Pires, dos Reis, A. Pires, Piron, L., Piron, C., Pironti, A., Pisano, F., Pitts, R., Plyusnin, V, Poli, F. M., Pomaro, N., Pompilian, O. G., Pool, P., Popovichev, S., Poradzinski, M., Porfiri, M. T., Porosnicu, C., Porton, M., Possnert, G., Potzel, S., Poulipoulis, G., Powell, T., Prajapati, V, Prakash, R., Predebon, I, Prestopino, G., Price, D., Price, M., Price, R., Primetzhofer, D., Prior, P., Pucella, G., Puglia, P., Puiatti, M. E., Purahoo, K., Pusztai, I, Puetterich, Th, Rachlew, E., Rack, M., Ragona, R., Rainford, M., Raj, P., Rakha, A., Ramogida, G., Ranjan, S., Rapson, C. J., Rasmussen, D., Rasmussen, J. J., Rathod, K., Ratta, G., Ratynskaia, S., Ravera, G., Rebai, M., Reed, A., Refy, D., Regana, J., Reich, M., Reid, N., Reimold, F., Reinhart, M., Reinke, M., Reiser, D., Rendell, D., Reux, C., Cortes, S. D. A. Reyes, Reynolds, S., Ricci, D., Richiusa, M., Rigamonti, D., Rimini, F. 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Veshchev, E, Vianello, N, Vicente, J, Viezzer, E, Villari, S, Villone, F, Vincent, M, Vincenzi, P, Vinyar, I, Viola, B, Vitins, A, Vizvary, Z, Vlad, M, Voitsekhovitch, I, Voltolina, D, von Toussaint, U, Vondracek, P, Vuksic, M, Wakeling, B, Waldon, C, Walkden, N, Walker, R, Walker, M, Walsh, M, Wang, N, Wang, E, Warder, S, Warren, R, Waterhouse, J, Watts, C, Wauters, T, Webb, M, Weckmann, A, Weiland, J, Weiland, M, Weisen, H, Weiszflog, M, Welch, P, West, A, Wheatley, M, Wheeler, S, Whitehead, Am, Whittaker, D, Widdowson, Am, Wiesen, S, Wilkie, G, Williams, J, Willoughby, D, Wilson, J, Wilson, I, Wilson, Hr, Wischmeier, M, Withycombe, A, Witts, D, Wolfrum, E, Wood, R, Woodley, R, Woodley, C, Wray, S, Wright, Jc, Wright, P, Wukitch, S, Wynn, A, Xiang, L, Xu, T, Xue, Y, Yadikin, D, Yakovenko, Y, Yanling, W, Yavorskij, V, Young, I, Young, R, Young, D, Zacks, J, Zagorski, R, Zaitsev, F, Zakharov, L, Zanino, R, Zarins, A, Zarins, R, Fernandez, Dz, Zastrow, Kd, Zerbini, M, Zhang, W, Zhou, Y, Zilli, E, Zocco, A, Zoita, V, Zoletnik, S, Zwingmann, W, and Zychor, I
Subjects: Nuclear and High Energy Physics, Computer science, ensembles of classifiers, Machine learning, computer.software_genre, disruptions, 01 natural sciences, 010305 fluids & plasmas, obsolescence, Ensembles of classifiers, Stationary conditions, 0103 physical sciences, 010306 general physics, de-learning, Jet (fluid), business.industry, machine learning predictors, adaptive training, JET, Settore ING-IND/18 - Fisica dei Reattori Nucleari, machine learning predictor, Condensed Matter Physics, disruption, Obsolescence, Artificial intelligence, Adaptive learning, business, computer
Abstract: For many years, machine learning tools have proved to be very powerful disruption predictors in tokamaks. On the other hand, the vast majority of the techniques deployed assume that the input data is independent and is sampled from exactly the same probability distribution for the training set, the test set and the final real time deployment. This hypothesis is certainly not verified in practice, since the experimental programmes evolve quite rapidly, resulting typically in ageing of the predictors and consequent suboptimal performance. This paper describes various adaptive training strategies that have been tested to maintain the performance of disruption predictors in non- stationary conditions. The proposed approaches have been implemented using new ensembles of classifiers, explicitly developed for the present application. The improvements in performance are unquestionable and, given the difficulties encountered so far in translating predictors from one device to another, the proposed adaptive methods from scratch can therefore be considered a useful option in the arsenal of alternatives envisaged for the next generation of devices, particularly at the very beginning of their operation.
Published: 2019
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7. Role of fast ion pressure in the isotope effect in JET L-mode plasmas

Author: Bonanomi, N., Casiraghi, I, Mantica, P., Challis, C., Delabie, E., Fable, E., Gallart, D., Giroud, C., Lerche, E., Lomas, P., Menmuir, S., Staebler, G. M., Taylor, D., Van Eester, D., Abduallev, S., Abhangi, M., Abreu, P., Afanasev, V, Afzal, M., Aggarwal, K. M., Ahlgren, T., Aho-Mantila, L., Aiba, N., Airila, M., Alarcon, T., Albanese, R., Alegre, D., Aleiferis, S., Alessi, E., Aleynikov, P., Alkseev, A., Allinson, M., Alper, B., Alves, E., Ambrosino, G., Ambrosino, R., Amosov, V, Sunden, E. Andersson, Andrews, R., Angelone, M., Anghel, M., Angioni, C., Appel, L., Appelbee, C., Arena, P., Ariola, M., Arshad, S., Artaud, J., Arter, W., Ash, A., Ashikawa, N., Aslanyan, V, Asunta, O., Asztalos, O., Auriemma, F., Austin, Y., Avotina, L., Axton, M., Ayres, C., Baciero, A., Baiao, D., Balboa, I, Balden, M., Balshaw, N., Bandaru, V. K., Banks, J., Baranov, Y. F., Barcellona, C., Barnard, T., Barnes, M., Barnsley, R., Wiechec, A. Baron, Orte, L. Barrera, Baruzzo, M., Basiuk, V, Bassan, M., Bastow, R., Batista, A., Batistoni, P., Baumane, L., Bauvir, B., Baylor, L., Beaumont, P. S., Beckers, M., Beckett, B., Bekris, N., Beldishevski, M., Bell, K., Belli, F., Belonohy, E., Benayas, J., Bergsaker, H., Bernardo, J., Bernert, M., Berry, M., Bertalot, L., Besiliu, C., Betar, H., Beurskens, M., Bielecki, J., Biewer, T., Bilato, R., Biletskyi, O., Bilkova, P., Binda, F., Birkenmeier, G., Bizarro, J. P. S., Bjorkas, C., Blackburn, J., Blackman, T. R., Blanchard, P., Blatchford, P., Bobkov, V, Boboc, A., Bogar, O., Bohm, P., Bohm, T., Bolshakova, I, Bolzonella, T., Boncagni, L., Bonfiglio, D., Bonnin, X., Boom, J., Borba, D., Borodin, D., Borodkina, I, Boulbe, C., Bourdelle, C., Bowden, M., Bowman, C., Boyce, T., Boyer, H., Bradnam, S. C., Braic, V, Bravanec, R., Breizman, B., Brennan, D., Breton, S., Brett, A., Brezinsek, S., Bright, M., Brix, M., Broeckx, W., Brombin, M., Broslawski, A., Brown, B., Brunetti, D., Bruno, E., Buch, J., Buchanan, J., Buckingham, R., Buckley, M., Bucolo, M., Budny, R., Bufferand, H., Buller, S., Bunting, P., Buratti, P., Burckhart, A., Burroughes, G., Buscarino, A., Busse, A., Butcher, D., Butler, B., Bykov, I, Cahyna, P., Calabro, G., Calacci, L., Callaghan, D., Callaghan, J., Calvo, I, Camenen, Y., Camp, P., Campling, D. C., Cannas, B., Capat, A., Carcangiu, S., Card, P., Cardinali, A., Carman, P., Carnevale, D., Carr, M., Carralero, D., Carraro, L., Carvalho, B. B., Carvalho, I, Carvalho, P., Carvalho, D. D., Casson, F. J., Castaldo, C., Catarino, N., Causa, F., Cavazzana, R., Cave-Ayland, K., Cavedon, M., Cecconello, M., Ceccuzzi, S., Cecil, E., Challis, C. D., Chandra, D., Chang, C. S., Chankin, A., Chapman, I. T., Chapman, B., Chapman, S. 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R., Corradino, C., Corre, Y., Corrigan, G., Coster, D., Craciunescu, T., Cramp, S., Crapper, C., Crisanti, F., Croci, G., Croft, D., Crombe, K., Cruz, N., Cseh, G., Cufar, A., Cullen, A., Curson, P., Curuia, M., Czarnecka, A., Czarski, T., Cziegler, I, Dabirikhah, H., Dal Molin, A., Dalgliesh, P., Dalley, S., Dankowski, J., Darrow, D., David, P., Davies, A., Davis, W., Dawson, K., Day, I, Day, C., De Bock, M., de Castro, A., De Dominici, G., de la Cal, E., de la Luna, E., De Masi, G., De Temmerman, G., De Tommasi, G., de Vries, P., Deane, J., Dejarnac, R., Del Sarto, D., Demerdzhiev, V, Dempsey, A., den Harder, N., Dendy, R. O., Denis, J., Denner, P., Devaux, S., Devynck, P., Di Maio, F., Di Siena, A., Di Troia, C., Dickinson, D., Dinca, P., Dittmar, T., Dobrashian, J., Doerk, H., Doerner, R. P., Domptail, F., Donne, T., Dorling, S. 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Vasilopoulou, T, Vecsei, M, Vega, J, Ventre, S, Verdoolaege, G, Verona, C, Rinati, Gv, Veshchev, E, Vianello, N, Vicente, J, Viezzer, E, Villari, S, Villone, F, Vincent, M, Vincenzi, P, Vinyar, I, Viola, B, Vitins, A, Vizvary, Z, Vlad, M, Voitsekhovitch, I, Voltolina, D, von Toussaint, U, Vondracek, P, Vuksic, M, Wakeling, B, Waldon, C, Walkden, N, Walker, R, Walker, M, Walsh, M, Wang, N, Wang, E, Warder, S, Warren, R, Waterhouse, J, Watts, C, Wauters, T, Webb, M, Weckmann, A, Weiland, J, Weiland, M, Weisen, H, Weiszflog, M, Welch, P, West, A, Wheatley, M, Wheeler, S, Whitehead, Am, Whittaker, D, Widdowson, Am, Wiesen, S, Wilkie, G, Williams, J, Willoughby, D, Wilson, J, Wilson, I, Wilson, Hr, Wischmeier, M, Withycombe, A, Witts, D, Wolfrum, E, Wood, R, Woodley, R, Woodley, C, Wray, S, Wright, Jc, Wright, P, Wukitch, S, Wynn, A, Xiang, L, Xu, T, Xue, Y, Yadikin, D, Yakovenko, Y, Yanling, W, Yavorskij, V, Young, I, Young, R, Young, D, Zacks, J, Zagorski, R, Zaitsev, F, Zakharov, L, Zanino, R, Zarins, A, Zarins, R, Fernandez, Dz, Zastrow, Kd, Zerbini, M, Zhang, W, Zhou, Y, Zilli, E, Zocco, A, Zoita, V, Zoletnik, S, Zwingmann, W, Zychor, I, Department of Physics, and Materials Physics
Subjects: Nuclear and High Energy Physics, Materials science, Hydrogen, chemistry.chemical_element, 114 Physical sciences, 7. Clean energy, 01 natural sciences, 010305 fluids & plasmas, Ion, gyrokinetic, JET tokamak, Physics::Plasma Physics, equations, turbulent transport, fast ions, isotope effect, gyrokinetic simulations, 0103 physical sciences, Kinetic isotope effect, drift orbit width, fast ion, Physics::Atomic Physics, Nuclear Experiment, 010306 general physics, Jet (fluid), Stable isotope ratio, turbulence, Plasma, gyrokinetic simulation, Condensed Matter Physics, chemistry, Deuterium, confinement, transport, Physics::Space Physics, simulations, Atomic physics, DRIFT ORBIT WIDTH, CONFINEMENT, SIMULATIONS, TURBULENCE, TRANSPORT, EQUATIONS, Ion cyclotron resonance
Abstract: This paper presents results of JET ITER-like wall L-mode experiments in hydrogen and deuterium (D) plasmas, dedicated to the study of the isotope dependence of ion heat transport by determination of the ion critical gradient and stiffness by varying the ion cyclotron resonance heating power deposition. When no strong role of fast ions in the plasma core is expected, the main difference between the two isotope plasmas is determined by the plasma edge and the core behavior is consistent with a gyro-Bohm scaling. When the heating power (and the fast ion pressure) is increased, in addition to the difference in the edge region, also the plasma core shows substantial changes. The stabilization of ion heat transport by fast ions, clearly visible in D plasmas, appears to be weaker in H plasmas, resulting in a higher ion heat flux in H with apparent anti-gyro-Bohm mass scaling. The difference is found to be caused by the different fast ion pressure between H and D plasmas, related to the heating power settings and to the different fast ion slowing down time, and is completely accounted for in non-linear gyrokinetic simulations. The application of the TGLF quasi-linear model to this set of data is also discussed.
Published: 2019
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8. Ion cyclotron resonance heating scenarios for DEMO

Author: Van Eester, D., Lerche, E., Ragona, R., Messiaen, A., Wauters, T., Abduallev, S., Abhangi, M., Abreu, P., Afanasev, V, Afzal, M., Aggarwal, K. M., Ahlgren, T., Aho-Mantila, L., Aiba, N., Airila, M., Alarcon, T., Albanese, R., Alegre, D., Aleiferis, S., Alessi, E., Aleynikov, P., Alkseev, A., Allinson, M., Alper, B., Alves, E., Ambrosino, G., Ambrosino, R., Amosov, V, Sunden, E. Andersson, Andrews, R., Angelone, M., Anghel, M., Angioni, C., Appel, L., Appelbee, C., Arena, P., Ariola, M., Arshad, S., Artaud, J., Arter, W., Ash, A., Ashikawa, N., Aslanyan, V, Asunta, O., Asztalos, O., Auriemma, F., Austin, Y., Avotina, L., Axton, M., Ayres, C., Baciero, A., Baiao, D., Balboa, I, Balden, M., Balshaw, N., Bandaru, V. K., Banks, J., Baranov, Y. F., Barcellona, C., Barnard, T., Barnes, M., Barnsley, R., Wiechec, A. Baron, Orte, L. Barrera, Baruzzo, M., Basiuk, V, Bassan, M., Bastow, R., Batista, A., Batistoni, P., Baumane, L., Bauvir, B., Baylor, L., Beaumont, P. S., Beckers, M., Beckett, B., Bekris, N., Beldishevski, M., Bell, K., Belli, F., Belonohy, E., Benayas, J., Bergsaker, H., Bernardo, J., Bernert, M., Berry, M., Bertalot, L., Besiliu, C., Betar, H., Beurskens, M., Bielecki, J., Biewer, T., Bilato, R., Biletskyi, O., Bilkova, P., Binda, F., Birkenmeier, G., Bizarro, J. P. S., Bjorkas, C., Blackburn, J., Blackman, T. R., Blanchard, P., Blatchford, P., Bobkov, V, Boboc, A., Bogar, O., Bohm, P., Bohm, T., Bolshakova, I, Bolzonella, T., Bonanomi, N., Boncagni, L., Bonfiglio, D., Bonnin, X., Boom, J., Borba, D., Borodin, D., Borodkina, I, Boulbe, C., Bourdelle, C., Bowden, M., Bowman, C., Boyce, T., Boyer, H., Bradnam, S. C., Braic, V, Bravanec, R., Breizman, B., Brennan, D., Breton, S., Brett, A., Brezinsek, S., Bright, M., Brix, M., Broeckx, W., Brombin, M., Broslawski, A., Brown, B., Brunetti, D., Bruno, E., Buch, J., Buchanan, J., Buckingham, R., Buckley, M., Bucolo, M., Budny, R., Bufferand, H., Buller, S., Bunting, P., Buratti, P., Burckhart, A., Burroughes, G., Buscarino, A., Busse, A., Butcher, D., Butler, B., Bykov, I, Cahyna, P., Calabro, G., Calacci, L., Callaghan, D., Callaghan, J., Calvo, I, Camenen, Y., Camp, P., Campling, D. C., Cannas, B., Capat, A., Carcangiu, S., Card, P., Cardinali, A., Carman, P., Carnevale, D., Carr, M., Carralero, D., Carraro, L., Carvalho, B. B., Carvalho, I, Carvalho, P., Carvalho, D. D., Casson, F. J., Castaldo, C., Catarino, N., Causa, F., Cavazzana, R., Cave-Ayland, K., Cavedon, M., Cecconello, M., Ceccuzzi, S., Cecil, E., Challis, C. D., Chandra, D., Chang, C. S., Chankin, A., Chapman, I. T., Chapman, B., Chapman, S. C., Chernyshova, M., Chiariello, A., Chitarin, G., Chmielewski, P., Chone, L., Ciraolo, G., Ciric, D., Citrin, J., Clairet, F., Clark, M., Clark, E., Clarkson, R., Clay, R., Clements, C., Coad, J. P., Coates, P., Cobalt, A., Coccorese, V, Cocilovo, V, Coelho, R., Coenen, J. W., Coffey, I, Colas, L., Colling, B., Collins, S., Conka, D., Conroy, S., Conway, N., Coombs, D., Cooper, S. R., Corradino, C., Corre, Y., Corrigan, G., Coster, D., Craciunescu, T., Cramp, S., Crapper, C., Crisanti, F., Croci, G., Croft, D., Crombe, K., Cruz, N., Cseh, G., Cufar, A., Cullen, A., Curson, P., Curuia, M., Czarnecka, A., Czarski, T., Cziegler, I, Dabirikhah, H., Dal Molin, A., Dalgliesh, P., Dalley, S., Dankowski, J., Darrow, D., David, P., Davies, A., Davis, W., Dawson, K., Day, I, Day, C., De Bock, M., de Castro, A., De Dominici, G., de la Cal, E., de la Luna, E., De Masi, G., De Temmerman, G., De Tommasi, G., de Vries, P., Deane, J., Dejarnac, R., Del Sarto, D., Delabie, E., Demerdzhiev, V, Dempsey, A., den Harder, N., Dendy, R. O., Denis, J., Denner, P., Devaux, S., Devynck, P., Di Maio, F., Di Siena, A., Di Troia, C., Dickinson, D., Dinca, P., Dittmar, T., Dobrashian, J., Doerk, H., Doerner, R. P., Domptail, F., Donne, T., Dorling, S. E., Douai, D., Dowson, S., Drenik, A., Dreval, M., Drewelow, P., Drews, P., Duckworth, Ph, Dumont, R., Dumortier, P., Dunai, D., Dunne, M., Duran, I, Durodie, F., Dutta, P., Duval, B. P., Dux, R., Dylst, K., Edappala, P. V., Edwards, A. M., Edwards, J. S., Eich, Th, Eidietis, N., Eksaeva, A., Ellis, R., Ellwood, G., Elsmore, C., Emery, S., Enachescu, M., Ericsson, G., Eriksson, J., Eriksson, F., Eriksson, L. G., Ertmer, S., Esquembri, S., Esquisabel, A. L., Esser, H. G., Ewart, G., Fable, E., Fagan, D., Faitsch, M., Falie, D., Fanni, A., Farahani, A., Fasoli, A., Faugeras, B., Fazinic, S., Felici, F., Felton, R. C., Feng, S., Fernades, A., Fernandes, H., Ferreira, J., Ferreira, D. R., Ferro, G., Fessey, J. A., Ficker, O., Field, A., Fietz, S., Figini, L., Figueiredo, J., Figueiredo, A., Fil, N., Finburg, P., Fischer, U., Fittill, L., Fitzgerald, M., Flammini, D., Flanagan, J., Flinders, K., Foley, S., Fonnesu, N., Fontdecaba, J. M., Formisano, A., Forsythe, L., Fortuna, L., Fransson, E., Frasca, M., Frassinetti, L., Freisinger, M., Fresa, R., Fridstrom, R., Frigione, D., Fuchs, V, Fusco, V, Futatani, S., Gal, K., Galassi, D., Galazka, K., Galeani, S., Gallart, D., Galvao, R., Gao, Y., Garcia, J., Garcia-Carrasco, A., Garcia-Munoz, M., Gardener, M., Garzotti, L., Gaspar, J., Gaudio, P., Gear, D., Gebhart, T., Gee, S., Geiger, B., Gelfusa, M., George, R., Gerasimov, S., Gervasini, G., Gethins, M., Ghani, Z., Ghate, M., Gherendi, M., Ghezzi, F., Giacalone, J. C., Giacomelli, L., Giacometti, G., Gibson, K., Giegerich, T., Gil, L., Gilbert, M. R., Gin, D., Giovannozzi, E., Giroud, C., Gloeggler, S., Goff, J., Gohil, P., Goloborod'ko, V, Gomes, R., Goncalves, B., Goniche, M., Goodyear, A., Gorini, G., Goerler, T., Goulding, R., Goussarov, A., Graham, B., Graves, J. P., Greuner, H., Grierson, B., Griffiths, J., Griph, S., Grist, D., Groth, M., Grove, R., Gruca, M., Guard, D., Guerard, C., Guillemaut, C., Guirlet, R., Gulati, S., Gurl, C., Gutierrez-Milla, A., Utoh, H. H., Hackett, L., Hacquin, S., Hager, R., Hakola, A., Halitovs, M., Hall, S., Hallworth-Cook, S., Ham, C., Hamed, M., Hamilton, N., Hamlyn-Harris, C., Hammond, K., Hancu, G., Harrison, J., Harting, D., Hasenbeck, F., Hatano, Y., Hatch, D. R., Haupt, T., Hawes, J., Hawkes, N. C., Hawkins, J., Hawkins, P., Hazel, S., Heesterman, P., Heinola, K., Hellesen, C., Hellsten, T., Helou, W., Hemming, O., Hender, T. C., Henderson, S. S., Henderson, M., Henriques, R., Hepple, D., Herfindal, J., Hermon, G., Hidalgo, C., Higginson, W., Highcock, E. G., Hillesheim, J., Hillis, D., Hizanidis, K., Hjalmarsson, A., Ho, A., Hobirk, J., Hogben, C. H. A., Hogeweij, G. M. D., Hollingsworth, A., Hollis, S., Hoelzl, M., Honore, J-J, Hook, M., Hopley, D., Horacek, J., Hornung, G., Horton, A., Horton, L. D., Horvath, L., Hotchin, S. P., Howell, R., Hubbard, A., Huber, A., Huber, V, Huddleston, T. M., Hughes, M., Hughes, J., Huijsmans, G. T. A., Huynh, P., Hynes, A., Igaune, I., Iglesias, D., Imazawa, N., Imrisek, M., Incelli, M., Innocente, P., Ivanova-Stanik, I., Ivings, E., Jachmich, S., Jackson, A., Jackson, T., Jacquet, P., Jansons, J., Jaulmes, F., Jednorog, S., Jenkins, I, Jepu, I, Johnson, T., Johnson, R., Johnston, J., Joita, L., Joly, J., Jonasson, E., Jones, T., Jones, C., Jones, L., Jones, G., Jones, N., Juvonen, M., Hoshino, K. K., Kallenbach, A., Kalsey, M., Kaltiaisenaho, T., Kamiya, K., Kaniewski, J., Kantor, A., Kappatou, A., Karhunen, J., Karkinsky, D., Kaufman, M., Kaveney, G., Kazakov, Y., Kazantzidis, V, Keeling, D. L., Keenan, F. P., Kempenaars, M., Kent, O., Kent, J., Keogh, K., Khilkevich, E., Kim, H-T, Kim, H. T., King, R., King, D., Kinna, D. J., Kiptily, V, Kirk, A., Kirov, K., Kirschner, A., Kizane, G., Klas, M., Klepper, C., Klix, A., Knight, M., Knight, P., Knipe, S., Knott, S., Kobuchi, T., Kochl, F., Kocsis, G., Kodeli, I, Koechl, F., Kogut, D., Koivuranta, S., Kolesnichenko, Y., Kollo, Z., Kominis, Y., Koeppen, M., Korolczuk, S., Kos, B., Koslowski, H. R., Kotschenreuther, M., Koubiti, M., Kovaldins, R., Kovanda, O., Kowalska-Strzeciwilk, E., Krasilnikov, A., Krasilnikov, V, Krawczyk, N., Kresina, M., Krieger, K., Krivska, A., Kruezi, U., Ksiazek, I, Kukushkin, A., Kundu, A., Kurki-Suonio, T., Kwak, S., Kwon, O. J., Laguardia, L., Lahtinen, A., Laing, A., Lalousis, P., Lam, N., Lamb, C., Lambertz, H. T., Lang, P. T., Lanthaler, S., Neto, E. Lascas, Laszynska, E., Lawless, R., Lawson, K. D., Lazaros, A., Lazzaro, E., Leach, R., Learoyd, G., Leerink, S., Lefebvre, X., Leggate, H. J., Lehmann, J., Lehnen, M., Leichauer, P., Leichtle, D., Leipold, F., Lengar, I, Lennholm, M., Lepiavko, B., Leppanen, J., Lescinskis, A., Lescinskis, B., Lesnoj, S., Leyland, M., Leysen, W., Li, Y., Li, L., Liang, Y., Likonen, J., Linke, J., Linsmeier, Ch, Lipschultz, B., Litaudon, X., Liu, G., Lloyd, B., Lo Schiavo, V. P., Loarer, T., Loarte, A., Lomanowski, B., Lomas, P. J., Lonnroth, J., Lopez, J. M., Lorenzini, R., Losada, U., Loughlin, M., Lowry, C., Luce, T., Lucock, R., Lukin, A., Luna, C., Lungaroni, M., Lungu, C. P., Lungu, M., Lunniss, A., Lunt, T., Lupelli, I, Lutsenko, V, Lyssoivan, A., Macheta, P., Macusova, E., Magesh, B., Maggi, C., Maggiora, R., Mahesan, S., Maier, H., Mailloux, J., Maingi, R., Makwana, R., Malaquias, A., Malinowski, K., Malizia, A., Manas, P., Manduchi, G., Manso, M. E., Mantica, P., Mantsinen, M., Manzanares, A., Maquet, Ph, Marandet, Y., Marcenko, N., Marchetto, C., Marchuk, O., Marconato, N., Mariani, A., Marin, M., Marinelli, M., Marinucci, M., Markovic, T., Marocco, D., Marot, L., Marsh, J., Martin, A., Martin de Aguilera, A., Martin-Solis, J. R., Martone, R., Martynova, Y., Maruyama, S., Maslov, M., Matejcik, S., Mattei, M., Matthews, G. F., Matveev, D., Matveeva, E., Mauriya, A., Maviglia, F., May-Smith, T., Mayer, M., Mayoral, M. L., Mazon, D., Mazzotta, C., McAdams, R., McCarthy, P. J., McClements, K. G., McCormack, O., McCullen, P. A., McDonald, D., McHardy, M., McKean, R., McKehon, J., McNamee, L., Meadowcroft, C., Meakins, A., Medley, S., Meigh, S., Meigs, A. 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R., Nocente, M., Nodwell, D., Nordlund, K., Nordman, H., Normanton, R., Noterdaeme, J. M., Nowak, S., Nunes, I, O'Gorman, T., O'Mullane, M., Oberkofler, M., Oberparleiter, M., Odupitan, T., Ogawa, M. T., Okabayashi, M., Oliver, H., Olney, R., Omoregie, L., Ongena, J., Orsitto, F., Orszagh, J., Osborne, T., Otin, R., Owen, A., Owen, T., Paccagnella, R., Packer, L. W., Pajuste, E., Pamela, S., Panja, S., Papp, P., Papp, G., Parail, V, Pardanaud, C., Diaz, F. Parra, Parsloe, A., Parsons, N., Parsons, M., Pasqualotto, R., Passeri, M., Patel, A., Pathak, S., Patten, H., Pau, A., Pautasso, G., Pavlichenko, R., Pavone, A., Pawelec, E., Soldan, C. Paz, Peackoc, A., Pehkonen, S-P, Peluso, E., Penot, C., Penzo, J., Pepperell, K., Pereira, R., Cippo, E. Perelli, von Thun, C. Perez, Pericoli, V, Peruzzo, S., Peterka, M., Petersson, P., Petravich, G., Petre, A., Petrzilka, V, Philipps, V, Pigatto, L., Pillon, M., Pinches, S., Pintsuk, G., Piovesan, P., de Sa, W. Pires, dos Reis, A. Pires, Piron, L., Piron, C., Pironti, A., Pisano, F., Pitts, R., Plyusnin, V, Poli, F. M., Pomaro, N., Pompilian, O. G., Pool, P., Popovichev, S., Poradzinski, M., Porfiri, M. T., Porosnicu, C., Porton, M., Possnert, G., Potzel, S., Poulipoulis, G., Powell, T., Prajapati, V, Prakash, R., Predebon, I, Prestopino, G., Price, D., Price, M., Price, R., Primetzhofer, D., Prior, P., Pucella, G., Puglia, P., Puiatti, M. E., Purahoo, K., Pusztai, I, Puetterich, Th, Rachlew, E., Rack, M., Rainford, M., Raj, P., Rakha, A., Ramogida, G., Ranjan, S., Rapson, C. J., Rasmussen, D., Rasmussen, J. J., Rathod, K., Ratta, G., Ratynskaia, S., Ravera, G., Rebai, M., Reed, A., Refy, D., Regana, J., Reich, M., Reid, N., Reimold, F., Reinhart, M., Reinke, M., Reiser, D., Rendell, D., Reux, C., Cortes, S. D. A. Reyes, Reynolds, S., Ricci, D., Richiusa, M., Rigamonti, D., Rimini, F. G., Risner, J., Riva, M., Rivero-Rodriguez, J., Roach, C., Robins, R., Robinson, S., Robson, D., Rodionov, R., Rodrigues, P., Rodriguez, J., Rohde, V, Romanelli, M., Romanelli, F., Romanelli, S., Romazanov, J., Rowe, S., Rubel, M., Rubinacci, G., Rubino, G., Ruchko, L., Ruset, C., Rzadkiewicz, J., Saarelma, S., Sabot, R., Saez, X., Safi, E., Sahlberg, A., Saibene, G., Saleem, M., Salewski, M., Salmi, A., Salmon, R., Salzedas, F., Samm, U., Sandiford, D., Santa, P., Santala, M. I. K., Santos, B., Santucci, A., Sartori, F., Sartori, R., Sauter, O., Scannell, R., Schluck, F., Schlummer, T., Schmid, K., Schmuck, S., Schoepf, K., Schweinzer, J., Schworer, D., Scott, S. D., Sergienko, G., Sertoli, M., Shabbir, A., Sharapov, S. E., Shaw, A., Sheikh, H., Shepherd, A., Shevelev, A., Shiraki, D., Shumack, A., Sias, G., Sibbald, M., Sieglin, B., Silburn, S., Silva, J., Silva, A., Silva, C., Silvagni, D., Simmons, P., Simpson, J., Sinha, A., Sipila, S. K., Sips, A. C. C., Siren, P., Sirinelli, A., Sjostrand, H., Skiba, M., Skilton, R., Skvara, V, Slade, B., Smith, R., Smith, P., Smith, S. F., Snoj, L., Soare, S., Solano, E. R., Somers, A., Sommariva, C., Sonato, P., Sos, M., Sousa, J., Sozzi, C., Spagnolo, S., Sparapani, P., Spelzini, T., Spineanu, F., Sprada, D., Sridhar, S., Stables, G., Stallard, J., Stamatelatos, I, Stamp, M. F., Stan-Sion, C., Stancar, Z., Staniec, P., Stankunas, G., Stano, M., Stavrou, C., Stefanikova, E., Stepanov, I, Stephen, A. V., Stephen, M., Stephens, J., Stevens, B., Stober, J., Stokes, C., Strachan, J., Strand, P., Strauss, H. R., Strom, P., Studholme, W., Subba, F., Suchkov, E., Summers, H. P., Sun, H., Sutton, N., Svensson, J., Sytnykov, D., Szabolics, T., Szepesi, G., Suzuki, T. 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Zastrow, Kd, Zerbini, M, Zhang, W, Zhou, Y, Zilli, E, Zocco, A, Zoita, V, Zoletnik, S, Zwingmann, W, and Zychor, I
Subjects: Nuclear and High Energy Physics, Tokamak, Materials science, heating, Sawtooth wave, wave, discharges, 114 Physical sciences, 7. Clean energy, 01 natural sciences, 010305 fluids & plasmas, law.invention, law, Physics::Plasma Physics, 0103 physical sciences, Dielectric heating, icrh, 010306 general physics, tokamak, mode conversion, iter, minority, Plasma, Condensed Matter Physics, plasmas, Computational physics, ICRH, ITER, current drive, Ion cyclotron resonance heating, sawtooth, oscillations, systems code
Abstract: The present paper offers an overview of the potential of ion cyclotron resonance heating (ICRH) or radio frequency heating for the DEMO machine. It is found that various suitable heating schemes are available. Similar to ITER and in view of the limited bandwidth of about 10 MHz that can be achieved to ensure optimal functioning of the launcher, it is proposed to make core second harmonic tritium heating the key ion heating scheme, assisted by fundamental cyclotron heating He-3 in the early phase of the discharge; for the present design of DEMO-with a static magnetic field strength of B-o = 5.855 T-that places the T and 3He layers in the core for f = 60 MHz and suggests centering the bandwidth around that main operating frequency. In line with earlier studies for hot, dense plasmas in large-size magnetic confinement machines, it is shown that good single pass absorption is achieved but that the size as well as the operating density and temperature of the machine cause the electrons to absorb a non-negligible fraction of the power away from the core when core ion heating is aimed at. Current drive and alternative heating options are briefly discussed and a dedicated computation is done for the traveling wave antenna, proposed for DEMO in view of its compatibility with substantial antenna-plasma distances. The various tasks that ICRH can fulfill are briefly listed. Finally, the impact of transport and the sensitivity of the obtained results to changes in the machine parameters is commented on.
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9. A new mechanism for increasing density peaking in tokamaks: improvement of the inward particle pinch with edge E x B shearing

Author: Garcia, J., Doerk, H., Goerler, T., Abduallev, S., Abhangi, M., Abreu, P., Afanasev, V, Afzal, M., Aggarwal, K. M., Ahlgren, T., Aho-Mantila, L., Aiba, N., Airila, M., Alarcon, T., Albanese, R., Alegre, D., Aleiferis, S., Alessi, E., Aleynikov, P., Alkseev, A., Allinson, M., Alper, B., Alves, E., Ambrosino, G., Ambrosino, R., Amosov, V, Sunden, E. Andersson, Andrews, R., Angelone, M., Anghel, M., Angioni, C., Appel, L., Appelbee, C., Arena, P., Ariola, M., Arshad, S., Artaud, J., Arter, W., Ash, A., Ashikawa, N., Aslanyan, V, Asunta, O., Asztalos, O., Auriemma, F., Austin, Y., Avotina, L., Axton, M., Ayres, C., Baciero, A., Baiao, D., Balboa, I, Balden, M., Balshaw, N., Bandaru, V. K., Banks, J., Baranov, Y. F., Barcellona, C., Barnard, T., Barnes, M., Barnsley, R., Wiechec, A. Baron, Orte, L. Barrera, Baruzzo, M., Basiuk, V, Bassan, M., Bastow, R., Batista, A., Batistoni, P., Baumane, L., Bauvir, B., Baylor, L., Beaumont, P. S., Beckers, M., Beckett, B., Bekris, N., Beldishevski, M., Bell, K., Belli, F., Belonohy, E., Benayas, J., Bergsaker, H., Bernardo, J., Bernert, M., Berry, M., Bertalot, L., Besiliu, C., Betar, H., Beurskens, M., Bielecki, J., Biewer, T., Bilato, R., Biletskyi, O., Bilkova, P., Binda, F., Birkenmeier, G., Bizarro, J. P. S., Bjorkas, C., Blackburn, J., Blackman, T. R., Blanchard, P., Blatchford, P., Bobkov, V, Boboc, A., Bogar, O., Bohm, P., Bohm, T., Bolshakova, I, Bolzonella, T., Bonanomi, N., Boncagni, L., Bonfiglio, D., Bonnin, X., Boom, J., Borba, D., Borodin, D., Borodkina, I, Boulbe, C., Bourdelle, C., Bowden, M., Bowman, C., Boyce, T., Boyer, H., Bradnam, S. C., Braic, V, Bravanec, R., Breizman, B., Brennan, D., Breton, S., Brett, A., Brezinsek, S., Bright, M., Brix, M., Broeckx, W., Brombin, M., Broslawski, A., Brown, B., Brunetti, D., Bruno, E., Buch, J., Buchanan, J., Buckingham, R., Buckley, M., Bucolo, M., Budny, R., Bufferand, H., Buller, S., Bunting, P., Buratti, P., Burckhart, A., Burroughes, G., Buscarino, A., Busse, A., Butcher, D., Butler, B., Bykov, I, Cahyna, P., Calabro, G., Calacci, L., Callaghan, D., Callaghan, J., Calvo, I, Camenen, Y., Camp, P., Campling, D. C., Cannas, B., Capat, A., Carcangiu, S., Card, P., Cardinali, A., Carman, P., Carnevale, D., Carr, M., Carralero, D., Carraro, L., Carvalho, B. B., Carvalho, I, Carvalho, P., Carvalho, D. D., Casson, F. J., Castaldo, C., Catarino, N., Causa, F., Cavazzana, R., Cave-Ayland, K., Cavedon, M., Cecconello, M., Ceccuzzi, S., Cecil, E., Challis, C. D., Chandra, D., Chang, C. S., Chankin, A., Chapman, I. T., Chapman, B., Chapman, S. C., Chernyshova, M., Chiariello, A., Chitarin, G., Chmielewski, P., Chone, L., Ciraolo, G., Ciric, D., Citrin, J., Clairet, F., Clark, M., Clark, E., Clarkson, R., Clay, R., Clements, C., Coad, J. P., Coates, P., Cobalt, A., Coccorese, V, Cocilovo, V, Coelho, R., Coenen, J. W., Coffey, I, Colas, L., Colling, B., Collins, S., Conka, D., Conroy, S., Conway, N., Coombs, D., Cooper, S. R., Corradino, C., Corre, Y., Corrigan, G., Coster, D., Craciunescu, T., Cramp, S., Crapper, C., Crisanti, F., Croci, G., Croft, D., Crombe, K., Cruz, N., Cseh, G., Cufar, A., Cullen, A., Curson, P., Curuia, M., Czarnecka, A., Czarski, T., Cziegler, I, Dabirikhah, H., Dal Molin, A., Dalgliesh, P., Dalley, S., Dankowski, J., Darrow, D., David, P., Davies, A., Davis, W., Dawson, K., Day, I, Day, C., De Bock, M., de Castro, A., De Dominici, G., de la Cal, E., de la Luna, E., De Masi, G., De Temmerman, G., De Tommasi, G., de Vries, P., Deane, J., Dejarnac, R., Del Sarto, D., Delabie, E., Demerdzhiev, V, Dempsey, A., den Harder, N., Dendy, R. O., Denis, J., Denner, P., Devaux, S., Devynck, P., Di Maio, F., Di Siena, A., Di Troia, C., Dickinson, D., Dinca, P., Dittmar, T., Dobrashian, J., Doerner, R. P., Domptail, F., Donne, T., Dorling, S. E., Douai, D., Dowson, S., Drenik, A., Dreval, M., Drewelow, P., Drews, P., Duckworth, Ph, Dumont, R., Dumortier, P., Dunai, D., Dunne, M., Duran, I, Durodie, F., Dutta, P., Duval, B. P., Dux, R., Dylst, K., Edappala, P., V, Edwards, A. M., Edwards, J. S., Eich, Th, Eidietis, N., Eksaeva, A., Ellis, R., Ellwood, G., Elsmore, C., Emery, S., Enachescu, M., Ericsson, G., Eriksson, J., Eriksson, F., Eriksson, L. G., Ertmer, S., Esquembri, S., Esquisabel, A. L., Esser, H. G., Ewart, G., Fable, E., Fagan, D., Faitsch, M., Falie, D., Fanni, A., Farahani, A., Fasoli, A., Faugeras, B., Fazinic, S., Felici, F., Felton, R. C., Feng, S., Fernades, A., Fernandes, H., Ferreira, J., Ferreira, D. R., Ferro, G., Fessey, J. A., Ficker, O., Field, A., Fietz, S., Figini, L., Figueiredo, J., Figueiredo, A., Fil, N., Finburg, P., Fischer, U., Fittill, L., Fitzgerald, M., Flammini, D., Flanagan, J., Flinders, K., Foley, S., Fonnesu, N., Fontdecaba, J. M., Formisano, A., Forsythe, L., Fortuna, L., Fransson, E., Frasca, M., Frassinetti, L., Freisinger, M., Fresa, R., Fridstrom, R., Frigione, D., Fuchs, V, Fusco, V, Futatani, S., Gal, K., Galassi, D., Galazka, K., Galeani, S., Gallart, D., Galvao, R., Gao, Y., Garcia-Carrasco, A., Garcia-Munoz, M., Gardener, M., Garzotti, L., Gaspar, J., Gaudio, P., Gear, D., Gebhart, T., Gee, S., Geiger, B., Gelfusa, M., George, R., Gerasimov, S., Gervasini, G., Gethins, M., Ghani, Z., Ghate, M., Gherendi, M., Ghezzi, F., Giacalone, J. C., Giacomelli, L., Giacometti, G., Gibson, K., Giegerich, T., Gil, L., Gilbert, M. R., Gin, D., Giovannozzi, E., Giroud, C., Gloeggler, S., Goff, J., Gohil, P., Goloborod'Ko, V, Gomes, R., Goncalves, B., Goniche, M., Goodyear, A., Gorini, G., Goulding, R., Goussarov, A., Graham, B., Graves, J. P., Greuner, H., Grierson, B., Griffiths, J., Griph, S., Grist, D., Groth, M., Grove, R., Gruca, M., Guard, D., Guerard, C., Guillemaut, C., Guirlet, R., Gulati, S., Gurl, C., Gutierrez-Milla, A., Utoh, H. H., Hackett, L., Hacquin, S., Hager, R., Hakola, A., Halitovs, M., Hall, S., Hallworth-Cook, S., Ham, C., Hamed, M., Hamilton, N., Hamlyn-Harris, C., Hammond, K., Hancu, G., Harrison, J., Harting, D., Hasenbeck, F., Hatano, Y., Hatch, D. R., Haupt, T., Hawes, J., Hawkes, N. C., Hawkins, J., Hawkins, P., Hazel, S., Heesterman, P., Heinola, K., Hellesen, C., Hellsten, T., Helou, W., Hemming, O., Hender, T. C., Henderson, S. S., Henderson, M., Henriques, R., Hepple, D., Herfindal, J., Hermon, G., Hidalgo, C., Higginson, W., Highcock, E. G., Hillesheim, J., Hillis, D., Hizanidis, K., Hjalmarsson, A., Ho, A., Hobirk, J., Hogben, C. H. A., Hogeweij, G. M. D., Hollingsworth, A., Hollis, S., Hoelzl, M., Honore, J-J, Hook, M., Hopley, D., Horacek, J., Hornung, G., Horton, A., Horton, L. D., Horvath, L., Hotchin, S. P., Howell, R., Hubbard, A., Huber, A., Huber, V, Huddleston, T. M., Hughes, M., Hughes, J., Huijsmans, G. T. A., Huynh, P., Hynes, A., Igaune, I., Iglesias, D., Imazawa, N., Imrisek, M., Incelli, M., Innocente, P., Ivanova-Stanik, I., Ivings, E., Jachmich, S., Jackson, A., Jackson, T., Jacquet, P., Jansons, J., Jaulmes, F., Jednorog, S., Jenkins, I, Jepu, I, Johnson, T., Johnson, R., Johnston, J., Joita, L., Joly, J., Jonasson, E., Jones, T., Jones, C., Jones, L., Jones, G., Jones, N., Juvonen, M., Hoshino, K. K., Kallenbach, A., Kalsey, M., Kaltiaisenaho, T., Kamiya, K., Kaniewski, J., Kantor, A., Kappatou, A., Karhunen, J., Karkinsky, D., Kaufman, M., Kaveney, G., Kazakov, Y., Kazantzidis, V, Keeling, D. L., Keenan, F. P., Kempenaars, M., Kent, O., Kent, J., Keogh, K., Khilkevich, E., Kim, H-T, Kim, H. T., King, R., King, D., Kinna, D. J., Kiptily, V, Kirk, A., Kirov, K., Kirschner, A., Kizane, G., Klas, M., Klepper, C., Klix, A., Knight, M., Knight, P., Knipe, S., Knott, S., Kobuchi, T., Kochl, F., Kocsis, G., Kodeli, I, Koechl, F., Kogut, D., Koivuranta, S., Kolesnichenko, Y., Kollo, Z., Kominis, Y., Koeppen, M., Korolczuk, S., Kos, B., Koslowski, H. R., Kotschenreuther, M., Koubiti, M., Kovaldins, R., Kovanda, O., Kowalska-Strzeciwilk, E., Krasilnikov, A., Krasilnikov, V, Krawczyk, N., Kresina, M., Krieger, K., Krivska, A., Kruezi, U., Ksiazek, I, Kukushkin, A., Kundu, A., Kurki-Suonio, T., Kwak, S., Kwon, O. J., Laguardia, L., Lahtinen, A., Laing, A., Lalousis, P., Lam, N., Lamb, C., Lambertz, H. T., Lang, P. T., Lanthaler, S., Neto, E. Lascas, Laszynska, E., Lawless, R., Lawson, K. D., Lazaros, A., Lazzaro, E., Leach, R., Learoyd, G., Leerink, S., Lefebvre, X., Leggate, H. 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E., Mantica, P., Mantsinen, M., Manzanares, A., Maquet, Ph, Marandet, Y., Marcenko, N., Marchetto, C., Marchuk, O., Marconato, N., Mariani, A., Marin, M., Marinelli, M., Marinucci, M., Markovic, T., Marocco, D., Marot, L., Marsh, J., Martin, A., Martin de Aguilera, A., Martin-Solis, J. R., Martone, R., Martynova, Y., Maruyama, S., Maslov, M., Matejcik, S., Mattei, M., Matthews, G. F., Matveev, D., Matveeva, E., Mauriya, A., Maviglia, F., May-Smith, T., Mayer, M., Mayoral, M. L., Mazon, D., Mazzotta, C., Mcadams, R., Mccarthy, P. J., Mcclements, K. G., Mccormack, O., Mccullen, P. A., Mcdonald, D., Mchardy, M., Mckean, R., Mckehon, J., Mcnamee, L., Meadowcroft, C., Meakins, A., Medley, S., Meigh, S., Meigs, A. 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D., Zerbini, M., Zhang, W., Zhou, Y., Zilli, E., Zocco, A., Zoita, V, Zoletnik, S., Zwingmann, W., Zychor, I, Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Max-Planck-Institut für Plasmaphysik [Garching] (IPP), Jet Contributors, European Project: 633053,H2020,EURATOM-Adhoc-2014-20,EUROfusion(2014), Garcia, J, Doerk, H, Gorler, T, Abduallev, S, Abhangi, M, Abreu, P, Afanasev, V, Afzal, M, Aggarwal, Km, Ahlgren, T, Aho-Mantila, L, Aiba, N, Airila, M, Alarcon, T, Albanese, R, Alegre, D, Aleiferis, S, Alessi, E, Aleynikov, P, Alkseev, A, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, Amosov, V, Sunden, Ea, Andrews, R, Angelone, M, Anghel, M, Angioni, C, Appel, L, Appelbee, C, Arena, P, Ariola, M, Arshad, S, Artaud, J, Arter, W, Ash, A, Ashikawa, N, Aslanyan, V, Asunta, O, Asztalos, O, Auriemma, F, Austin, Y, Avotina, L, Axton, M, Ayres, C, Baciero, A, Baiao, D, Balboa, I, Balden, M, 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Brown, B, Brunetti, D, Bruno, E, Buch, J, Buchanan, J, Buckingham, R, Buckley, M, Bucolo, M, Budny, R, Bufferand, H, Buller, S, Bunting, P, Buratti, P, Burckhart, A, Burroughes, G, Buscarino, A, Busse, A, Butcher, D, Butler, B, Bykov, I, Cahyna, P, Calabro, G, Calacci, L, Callaghan, D, Callaghan, J, Calvo, I, Camenen, Y, Camp, P, Campling, Dc, Cannas, B, Capat, A, Carcangiu, S, Card, P, Cardinali, A, Carman, P, Carnevale, D, Carr, M, Carralero, D, Carraro, L, Carvalho, Bb, Carvalho, I, Carvalho, P, Carvalho, Dd, Casson, Fj, Castaldo, C, Catarino, N, Causa, F, Cavazzana, R, Cave-Ayland, K, Cavedon, M, Cecconello, M, Ceccuzzi, S, Cecil, E, Challis, Cd, Chandra, D, Chang, C, Chankin, A, Chapman, It, Chapman, B, Chapman, Sc, Chernyshova, M, Chiariello, A, Chitarin, G, Chmielewski, P, Chone, L, Ciraolo, G, Ciric, D, Citrin, J, Clairet, F, Clark, M, Clark, E, Clarkson, R, Clay, R, Clements, C, Coad, Jp, Coates, P, Cobalt, A, Coccorese, V, Cocilovo, V, Coelho, R, Coenen, Jw, Coffey, I, Colas, L, Colling, B, Collins, S, Conka, D, Conroy, S, Conway, N, Coombs, D, Cooper, Sr, Corradino, C, Corre, Y, Corrigan, G, Coster, D, Craciunescu, T, Cramp, S, Crapper, C, Crisanti, F, Croci, G, Croft, D, Crombe, K, Cruz, N, Cseh, G, Cufar, A, Cullen, A, Curson, P, Curuia, M, Czarnecka, A, Czarski, T, Cziegler, I, Dabirikhah, H, Dal Molin, A, Dalgliesh, P, Dalley, S, Dankowski, J, Darrow, D, David, P, Davies, A, Davis, W, Dawson, K, Day, I, Day, C, De Bock, M, de Castro, A, De Dominici, G, de la Cal, E, de la Luna, E, De Masi, G, De Temmerman, G, De Tommasi, G, de Vries, P, Deane, J, Dejarnac, R, Del Sarto, D, Delabie, E, Demerdzhiev, V, Dempsey, A, den Harder, N, Dendy, Ro, Denis, J, Denner, P, Devaux, S, Devynck, P, Di Maio, F, Di Siena, A, Di Troia, C, Dickinson, D, Dinca, P, Dittmar, T, Dobrashian, J, Doerner, Rp, Domptail, F, Donne, T, Dorling, Se, Douai, D, Dowson, S, Drenik, A, Dreval, M, Drewelow, P, Drews, P, Duckworth, P, Dumont, R, Dumortier, P, Dunai, D, Dunne, M, Duran, I, 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F, Lengar, I, Lennholm, M, Lepiavko, B, Leppanen, J, Lerche, E, Lescinskis, A, Lescinskis, B, Lesnoj, S, Leyland, M, Leysen, W, Li, Y, Li, L, Liang, Y, Likonen, J, Linke, J, Linsmeier, C, Lipschultz, B, Litaudon, X, Liu, G, Lloyd, B, Lo Schiavo, Vp, Loarer, T, Loarte, A, Lomanowski, B, Lomas, Pj, Lonnroth, J, Lopez, Jm, Lorenzini, R, Losada, U, Loughlin, M, Lowry, C, Luce, T, Lucock, R, Lukin, A, Luna, C, Lungaroni, M, Lungu, Cp, Lungu, M, Lunniss, A, Lunt, T, Lupelli, I, Lutsenko, V, Lyssoivan, A, Macheta, P, Macusova, E, Magesh, B, Maggi, C, Maggiora, R, Mahesan, S, Maier, H, Mailloux, J, Maingi, R, Makwana, R, Malaquias, A, Malinowski, K, Malizia, A, Manas, P, Manduchi, G, Manso, Me, Mantica, P, Mantsinen, M, Manzanares, A, Maquet, P, Marandet, Y, Marcenko, N, Marchetto, C, Marchuk, O, Marconato, N, Mariani, A, Marin, M, Marinelli, M, Marinucci, M, Markovic, T, Marocco, D, Marot, L, Marsh, J, Martin, A, de Aguilera, Am, Martin-Solis, Jr, Martone, R, Martynova, Y, Maruyama, S, Maslov, M, Matejcik, S, Mattei, M, Matthews, Gf, Matveev, D, Matveeva, E, Mauriya, A, Maviglia, F, May-Smith, T, Mayer, M, Mayoral, Ml, Mazon, D, Mazzotta, C, Mcadams, R, Mccarthy, Pj, Mcclements, Kg, Mccormack, O, Mccullen, Pa, Mcdonald, D, Mchardy, M, Mckean, R, Mckehon, J, Mcnamee, L, Meadowcroft, C, Meakins, A, Medley, S, Meigh, S, Meigs, Ag, Meisl, G, Meiter, S, Meitner, S, Meneses, L, Menmuir, S, Mergia, K, Merle, A, Merriman, P, Mertens, P, Meshchaninov, S, Messiaen, A, Meyer, H, Michling, R, Milanesio, D, Militello, F, Militello-Asp, E, Milocco, A, Miloshevsky, G, Mink, F, Minucci, S, Miron, I, Mistry, S, Miyoshi, Y, Mlynar, J, Moiseenko, V, Monaghan, P, Monakhov, I, Moon, S, Mooney, R, Moradi, S, Morales, J, Moran, J, Mordijck, S, Moreira, L, Moro, F, Morris, J, Moser, L, Mosher, S, Moulton, D, Mrowetz, T, Muir, A, Muraglia, M, Murari, A, Muraro, A, Murphy, S, Muscat, P, Muthusonai, N, Myers, C, Asakura, Nn, N'Konga, B, Nabais, F, Naish, R, Naish, J, Nakano, T, Napoli, F, Nardon, E, Naulin, V, Nave, Mff, Nedzelskiy, I, Nemtsev, G, Nesenevich, V, Nespoli, F, Neto, A, Neu, R, Neverov, V, Newman, M, Ng, S, Nicassio, M, Nielsen, Ah, Nina, D, Nishijima, D, Noble, C, Nobs, Cr, Nocente, M, Nodwell, D, Nordlund, K, Nordman, H, Normanton, R, Noterdaeme, Jm, Nowak, S, Nunes, I, O'Gorman, T, O'Mullane, M, Oberkofler, M, Oberparleiter, M, Odupitan, T, Ogawa, Mt, Okabayashi, M, Oliver, H, Olney, R, Omoregie, L, Ongena, J, Orsitto, F, Orszagh, J, Osborne, T, Otin, R, Owen, A, Owen, T, Paccagnella, R, Packer, Lw, Pajuste, E, Pamela, S, Panja, S, Papp, P, Papp, G, Parail, V, Pardanaud, C, Diaz, Fp, Parsloe, A, Parsons, N, Parsons, M, Pasqualotto, R, Passeri, M, Patel, A, Pathak, S, Patten, H, Pau, A, Pautasso, G, Pavlichenko, R, Pavone, A, Pawelec, E, Soldan, Cp, Peackoc, A, Pehkonen, Sp, Peluso, E, Penot, C, Penzo, J, Pepperell, K, Pereira, R, Cippo, Ep, von Thun, Cp, Pericoli, V, Peruzzo, S, Peterka, M, Petersson, P, Petravich, G, Petre, A, Petrzilka, V, Philipps, V, Pigatto, L, Pillon, M, Pinches, S, Pintsuk, G, Piovesan, P, de Sa, Wp, dos Reis, Ap, Piron, L, Piron, C, Pironti, A, Pisano, F, Pitts, R, Plyusnin, V, Poli, Fm, Pomaro, N, Pompilian, Og, Pool, P, Popovichev, S, Poradzinski, M, Porfiri, Mt, Porosnicu, C, Porton, M, Possnert, G, Potzel, S, Poulipoulis, G, Powell, T, Prajapati, V, Prakash, R, Predebon, I, Prestopino, G, Price, D, Price, M, Price, R, Primetzhofer, D, Prior, P, Pucella, G, Puglia, P, Puiatti, Me, Purahoo, K, Pusztai, I, Putterich, T, Rachlew, E, Rack, M, Ragona, R, Rainford, M, Raj, P, Rakha, A, Ramogida, G, Ranjan, S, Rapson, Cj, Rasmussen, D, Rasmussen, Jj, Rathod, K, Ratta, G, Ratynskaia, S, Ravera, G, Rebai, M, Reed, A, Refy, D, Regana, J, Reich, M, Reid, N, Reimold, F, Reinhart, M, Reinke, M, Reiser, D, Rendell, D, Reux, C, Cortes, Sdar, Reynolds, S, Ricci, D, Richiusa, M, Rigamonti, D, Rimini, Fg, Risner, J, Riva, M, Rivero-Rodriguez, J, Roach, C, Robins, R, Robinson, S, Robson, D, Rodionov, R, Rodrigues, P, Rodriguez, J, Rohde, V, Romanelli, M, Romanelli, F, Romanelli, S, Romazanov, J, Rowe, S, Rubel, M, Rubinacci, G, Rubino, G, Ruchko, L, Ruset, C, Rzadkiewicz, J, Saarelma, S, Sabot, R, Saez, X, Safi, E, Sahlberg, A, Saibene, G, Saleem, M, Salewski, M, Salmi, A, Salmon, R, Salzedas, F, Samm, U, Sandiford, D, Santa, P, Santala, Mik, Santos, B, Santucci, A, Sartori, F, Sartori, R, Sauter, O, Scannell, R, Schluck, F, Schlummer, T, Schmid, K, Schmuck, S, Schopf, K, Schweinzer, J, Schworer, D, Scott, Sd, Sergienko, G, Sertoli, M, Shabbir, A, Sharapov, Se, Shaw, A, Sheikh, H, Shepherd, A, Shevelev, A, Shiraki, D, Shumack, A, Sias, G, Sibbald, M, Sieglin, B, Silburn, S, Silva, J, Silva, A, Silva, C, Silvagni, D, Simmons, P, Simpson, J, Sinha, A, Sipila, Sk, Sips, Acc, Siren, P, Sirinelli, A, Sjostrand, H, Skiba, M, Skilton, R, Skvara, V, Slade, B, Smith, R, Smith, P, Smith, Sf, Snoj, L, Soare, S, Solano, Er, Somers, A, Sommariva, C, Sonato, P, Sos, M, Sousa, J, Sozzi, C, Spagnolo, S, Sparapani, P, Spelzini, T, Spineanu, F, Sprada, D, Sridhar, S, Stables, G, Stallard, J, Stamatelatos, I, Stamp, Mf, Stan-Sion, C, Stancar, Z, Staniec, P, Stankunas, G, Stano, M, Stavrou, C, Stefanikova, E, Stepanov, I, Stephen, Av, Stephen, M, Stephens, J, Stevens, B, Stober, J, Stokes, C, Strachan, J, Strand, P, Strauss, Hr, Strom, P, Studholme, W, Subba, F, Suchkov, E, Summers, Hp, Sun, H, Sutton, N, Svensson, J, Sytnykov, D, Szabolics, T, Szepesi, G, Suzuki, Tt, Tabares, F, Tadic, T, Tal, B, Tala, T, Taliercio, C, Tallargio, A, Tanaka, K, Tang, W, Tardocchi, M, Tatali, R, Taylor, D, Tegnered, D, Telesca, G, Teplova, N, Teplukhina, A, Terranova, D, Terry, C, Testa, D, Tholerus, E, Thomas, J, Thompson, Vk, Thornton, A, Tierens, W, Tiseanu, I, Tojo, H, Tokitani, M, Tolias, P, Tomes, M, Trimble, P, Tripsky, M, Tsalas, M, Tsavalas, P, Tskhakaya, D, Jun, Dt, Turner, I, Turner, Mm, Turnyanskiy, M, Tvalashvili, G, Tyshchenko, M, Uccello, A, Uljanovs, J, Urano, H, Urban, A, Urbanczyk, G, Uytdenhouwen, I, Vadgama, A, Valcarcel, D, Vale, R, Valentinuzzi, M, Valerii, K, Valisa, M, Olivares, Pv, Valovic, M, Van Eester, D, Van Renterghem, W, van Rooij, Gj, Varje, J, Vartanian, S, Vasava, K, Vasilopoulou, T, Vecsei, M, Vega, J, Ventre, S, Verdoolaege, G, Verona, C, Rinati, Gv, Veshchev, E, Vianello, N, Vicente, J, Viezzer, E, Villari, S, Villone, F, Vincent, M, Vincenzi, P, Vinyar, I, Viola, B, Vitins, A, Vizvary, Z, Vlad, M, Voitsekhovitch, I, Voltolina, D, von Toussaint, U, Vondracek, P, Vuksic, M, Wakeling, B, Waldon, C, Walkden, N, Walker, R, Walker, M, Walsh, M, Wang, N, Wang, E, Warder, S, Warren, R, Waterhouse, J, Watts, C, Wauters, T, Webb, M, Weckmann, A, Weiland, J, Weiland, M, Weisen, H, Weiszflog, M, Welch, P, West, A, Wheatley, M, Wheeler, S, Whitehead, Am, Whittaker, D, Widdowson, Am, Wiesen, S, Wilkie, G, Williams, J, Willoughby, D, Wilson, J, Wilson, I, Wilson, Hr, Wischmeier, M, Withycombe, A, Witts, D, Wolfrum, E, Wood, R, Woodley, R, Woodley, C, Wray, S, Wright, Jc, Wright, P, Wukitch, S, Wynn, A, Xiang, L, Xu, T, Xue, Y, Yadikin, D, Yakovenko, Y, Yanling, W, Yavorskij, V, Young, I, Young, R, Young, D, Zacks, J, Zagorski, R, Zaitsev, F, Zakharov, L, Zanino, R, Zarins, A, Zarins, R, Fernandez, Dz, Zastrow, Kd, Zerbini, M, Zhang, W, Zhou, Y, Zilli, E, Zocco, A, Zoita, V, Zoletnik, S, Zwingmann, W, Zychor, I, and JET Contributors
Subjects: Tokamak, Plasma turbulence, Extrapolation, turbulence, transport, plasma, JET, 7. Clean energy, 01 natural sciences, 010305 fluids & plasmas, law.invention, law, Physics::Plasma Physics, jet, 0103 physical sciences, 010306 general physics, plasma, Physics, Shearing (physics), [PHYS]Physics [physics], Turbulence, Plasma, Mechanics, JET, Condensed Matter Physics, Nuclear Energy and Engineering, Pinch
Abstract: See also: Plasma Physics and Controlled Fusion, 61, 104002 (2019)Special Issue on the 2018 Joint Varenna-Lausanne International Workshop on the Theory of Fusion Plasmas; International audience; Developing successful tokamak operation scenarios, as well as confident extrapolation of present-day knowledge requires a rigorous understanding of plasma turbulence, which largely determines the quality of the confinement. In particular, accurate particle transport predictions are essential due to the strong dependence of fusion power or bootstrap current on the particle density details. Here, gyrokinetic turbulence simulations are performed with physics inputs taken from a JET power scan, for which a relatively weak degradation of energy confinement and a significant density peaking is obtained with increasing input power. This way physics parameters that lead to such increase in the density peaking shall be elucidated. While well-known candidates, such as the collisionality, previously found in other studies are also recovered in this study, it is furthermore found that edge $E×B$ shearing may adopt a crucial role by enhancing the inward pinch. These results may indicate that a plasma with rotational shear could develop a stronger density peaking as compared to a non-rotating one, because its inward convection is increased compared to the outward diffusive particle flux as long as this rotation has a significant on $E$X$B$ flow shear stabilisation. The possibly significant implications for future devices, which will exhibit much less torque compared to present day experiments, are discussed.
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10. CNS-wide repopulation by hematopoietic-derived microglia-like cells corrects progranulin deficiency in mice.

Author: Colella P, Sayana R, Suarez-Nieto MV, Sarno J, Nyame K, Xiong J, Pimentel Vera LN, Arozqueta Basurto J, Corbo M, Limaye A, Davis KL, Abu-Remaileh M, and Gomez-Ospina N
Subjects: Animals, Mice, Hematopoietic Stem Cell Transplantation, Aminopyridines pharmacology, Brain metabolism, Pyrroles pharmacology, Mice, Inbred C57BL, Hematopoietic Stem Cells metabolism, Hematopoietic Stem Cells drug effects, Hematopoietic Stem Cells cytology, Bone Marrow Transplantation, Male, Central Nervous System metabolism, Mice, Knockout, Transplantation Conditioning methods, Single-Cell Analysis, Cytokines metabolism, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor metabolism, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor genetics, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor antagonists & inhibitors, Microglia metabolism, Microglia drug effects, Progranulins metabolism, Progranulins genetics, Busulfan pharmacology
Abstract: Hematopoietic stem cell transplantation can deliver therapeutic proteins to the central nervous system (CNS) through transplant-derived microglia-like cells. However, current conditioning approaches result in low and slow engraftment of transplanted cells in the CNS. Here we optimized a brain conditioning regimen that leads to rapid, robust, and persistent microglia replacement without adverse effects on neurobehavior or hematopoiesis. This regimen combines busulfan myeloablation and six days of Colony-stimulating factor 1 receptor inhibitor PLX3397. Single-cell analyses revealed unappreciated heterogeneity of microglia-like cells with most cells expressing genes characteristic of homeostatic microglia, brain-border-associated macrophages, and unique markers. Cytokine analysis in the CNS showed transient inductions of myeloproliferative and chemoattractant cytokines that help repopulate the microglia niche. Bone marrow transplant of progranulin-deficient mice conditioned with busulfan and PLX3397 restored progranulin in the brain and eyes and normalized brain lipofuscin storage, proteostasis, and lipid metabolism. This study advances our understanding of CNS repopulation by hematopoietic-derived cells and demonstrates its therapeutic potential for treating progranulin-dependent neurodegeneration., (© 2024. The Author(s).)
Published: 2024
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11. Ex vivo discovery of synergistic drug combinations for hematologic malignancies.

Author: Ali KA, Shah RD, Dhar A, Myers NM, Nguyen C, Paul A, Mancuso JE, Scott Patterson A, Brody JP, and Heiser D
Subjects: Humans, Drug Synergism, Drug Combinations, Panobinostat therapeutic use, Leukemia, Myeloid, Acute drug therapy, Leukemia, Myeloid, Acute metabolism, Leukemia, Myeloid, Acute pathology, Hematologic Neoplasms drug therapy
Abstract: Combination therapies have improved outcomes for patients with acute myeloid leukemia (AML). However, these patients still have poor overall survival. Although many combination therapies are identified with high-throughput screening (HTS), these approaches are constrained to disease models that can be grown in large volumes (e.g., immortalized cell lines), which have limited translational utility. To identify more effective and personalized treatments, we need better strategies for screening and exploring potential combination therapies. Our objective was to develop an HTS platform for identifying effective combination therapies with highly translatable ex vivo disease models that use size-limited, primary samples from patients with leukemia (AML and myelodysplastic syndrome). We developed a system, ComboFlow, that comprises three main components: MiniFlow, ComboPooler, and AutoGater. MiniFlow conducts ex vivo drug screening with a miniaturized flow-cytometry assay that uses minimal amounts of patient sample to maximize throughput. ComboPooler incorporates computational methods to design efficient screens of pooled drug combinations. AutoGater is an automated gating classifier for flow cytometry that uses machine learning to rapidly analyze the large datasets generated by the assay. We used ComboFlow to efficiently screen more than 3000 drug combinations across 20 patient samples using only 6 million cells per patient sample. In this screen, ComboFlow identified the known synergistic combination of bortezomib and panobinostat. ComboFlow also identified a novel drug combination, dactinomycin and fludarabine, that synergistically killed leukemic cells in 35 % of AML samples. This combination also had limited effects in normal, hematopoietic progenitors. In conclusion, ComboFlow enables exploration of massive landscapes of drug combinations that were previously inaccessible in ex vivo models. We envision that ComboFlow can be used to discover more effective and personalized combination therapies for cancers amenable to ex vivo models., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Kamran A. Ali reports financial support was provided by Notable Labs. Kamran A. Ali reports a relationship with Notable Labs that includes: employment. Reecha D. Shah reports a relationship with Notable Labs that includes: employment. Anukriti Dhar reports a relationship with Notable Labs that includes: employment. Nina M. Myers reports a relationship with Notable Labs that includes: employment. Cameron Nguyen reports a relationship with Notable Labs that includes: employment. Arisa Paul reports a relationship with Notable Labs that includes: employment. Jordan E. Mancuso reports a relationship with Notable Labs that includes: employment. A. Scott Patterson reports a relationship with Notable Labs that includes: employment. Diane Heiser reports a relationship with Notable Labs that includes: employment., (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Published: 2024
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12. A genomic region associated with iteroparous spawning phenology is linked with age-at-maturity in female steelhead trout.

Author: Willis S, Stephenson J, Pierce A, Medeiros L, Jenkins L, Hatch DR, and Narum S
Abstract: Age-at-maturity and iteroparity are two life history variations of steelhead trout ( Oncorhynchus mykiss ) that are believed to increase population resilience and stability. While repeat-spawning individuals are thought to have historically made up a substantial portion of the reproductive population in the Columbia River and the majority of females still attempt outmigration as kelts, return rates of repeat-spawner are low throughout the basin and below 1% for the furthest migrating stocks. Notably, outmigrating adults exhibit variation in rematuration phenology, displaying either "consecutive" (reproduce immediately the following season) or "skip" (delay spawning for future seasons) spawning patterns. Here, we use low coverage whole genome sequencing of consecutive versus skip spawning female Columbia River steelhead from two populations to test for genomic differences between these two iteroparous phenotypes. We identified genomic regions on several chromosomes which were associated with the phenology of iteroparity, including a region on chromosome 25 containing two genes, estradiol receptor beta ( ER β) and glycoprotein hormone beta-5 ( GPHB5 ), which, in mammals, are estrogen-sensitive and expressed in reproductive tissues. Allele frequencies in this ER β/ GPHB5 region differed among female steelhead of different age at maturity, but not males. These genes also shared an island of linkage disequilibrium with the SIX6 gene, 600Kbp away on the same chromosome, a region of known association with age-at-maturity. These observations contribute to growing evidence that age-at-maturity and the phenology of iteroparity are determined by overlapping physiological processes and genetic pathways., (© 2023 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd.)
Published: 2023
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13. CNS Repopulation by Hematopoietic-Derived Microglia-Like Cells Corrects Progranulin deficiency.

Author: Colella P, Sayana R, Suarez-Nieto MV, Sarno J, Nyame K, Xiong J, Vera LNP, Basurto JA, Corbo M, Limaye A, Davis KL, Abu-Remaileh M, and Gomez-Ospina N
Abstract: Hematopoietic stem cell transplantation can deliver therapeutic proteins to the CNS through donor-derived hematopoietic cells that become microglia-like cells. However, using standard conditioning approaches, hematopoietic stem cell transplantation is currently limited by low and slow engraftment of microglia-like cells. We report an efficient conditioning regimen based on Busulfan and a six-day course of microglia depletion using the colony-stimulating factor receptor 1 inhibitor PLX3397. Combining Busulfan-myeloablation and transient microglia depletion results in robust, rapid, and persistent microglia replacement by bone marrow-derived microglia-like cells throughout the CNS. Adding PLX3397 does not affect neurobehavior or has adverse effects on hematopoietic reconstitution. Through single-cell RNA sequencing and high-dimensional CyTOF mass cytometry, we show that microglia-like cells are a heterogeneous population and describe six distinct subpopulations. Though most bone-marrow-derived microglia-like cells can be classified as homeostatic microglia, their gene signature is a hybrid of homeostatic/embryonic microglia and border associated-macrophages. Busulfan-myeloablation and transient microglia depletion induce specific cytokines in the brain, ultimately combining myeloid proliferative and chemo-attractive signals that act locally to repopulate microglia from outside the niche. Importantly, this conditioning approach demonstrates therapeutic efficacy in a mouse model of GRN deficiency. Transplanting wild-type bone marrow into Grn -/- mice conditioned with Busulfan plus PLX3397 results in high engraftment of microglia-like cells in the brain and retina, restoring GRN levels and normalizing lipid metabolism.
Published: 2023
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14. Comparing pedestal structure in JET-ILW H-mode plasmas with a model for stiff ETG turbulent heat transport.

Author: Field AR, Chapman-Oplopoiou B, Connor JW, Frassinetti L, Hatch DR, Roach CM, and Saarelma S
Abstract: A predictive model for the electron temperature profile of the H-mode pedestal is described, and its results are compared with the pedestal structure of JET-ILW plasmas. The model is based on a scaling for the gyro-Bohm normalized, turbulent electron heat flux [Formula: see text] resulting from electron temperature gradient (ETG) turbulence, derived from results of nonlinear gyrokinetic (GK) calculations for the steep gradient region. By using the local temperature gradient scale length [Formula: see text] in the normalization, the dependence of [Formula: see text] on the normalized gradients [Formula: see text] and [Formula: see text] can be represented by a unified scaling with the parameter [Formula: see text], to which the linear stability of ETG turbulence is sensitive when the density gradient is sufficiently steep. For a prescribed density profile, the value of [Formula: see text] determined from this scaling, required to maintain a constant electron heat flux [Formula: see text] across the pedestal, is used to calculate the temperature profile. Reasonable agreement with measurements is found for different cases, the model providing an explanation of the relative widths and shifts of the [Formula: see text] and [Formula: see text] profiles, as well as highlighting the importance of the separatrix boundary conditions. Other cases showing disagreement indicate conditions where other branches of turbulence might dominate. This article is part of a discussion meeting issue 'H-mode transition and pedestal studies in fusion plasmas'.
Published: 2023
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15. Feeding after spawning and energy balance at spawning are associated with repeat spawning interval in steelhead trout.

Author: Jenkins LE, Medeiros LR, Graham ND, Hoffman BM, Cervantes DL, Hatch DR, Nagler JJ, and Pierce AL
Subjects: Animals, Female, Growth Hormone, Oncorhynchus mykiss
Abstract: Consecutive and skip repeat spawning (1- or ≥2-year spawning interval) life histories commonly occur in seasonally breeding iteroparous fishes. Spawning interval variation is driven by energetic status and impacts fisheries management. In salmonids, energetic status (either absolute level of energy reserves or the rate of change of energy reserves, i.e., energy balance) is thought to determine reproductive trajectory during a critical period ∼1 year prior to initial spawning. However, information on repeat spawners is lacking. To examine the timing and the aspects of energetic status that regulate repeat spawning interval, female steelhead trout (Oncorhynchus mykiss) were fasted for 10 weeks after spawning and then fed ad libitum and compared to ad libitum fed controls. Plasma growth hormone (GH) and insulin-like growth factor-I (IGF-I) levels were measured to assess long-term energy balance. Plasma estradiol levels showed that some fish in both groups initiated a consecutive spawning cycle. In fasted fish, GH was lower at spawning in consecutive versus skip spawners. In consecutive spawners, GH was higher at spawning in fed versus fasted fish. These results suggest that fish with a less negative energy balance at spawning initiated reproductive development in the absence of feeding, but that feeding during the post-spawning period enabled initiation of reproduction in some fish with a more negative energy balance at spawning. Thus, both energy balance at spawning and feeding after spawning regulated reproductive schedules. These results show that the critical period model of salmonid maturation applies to regulation of repeat spawning, and that the reproductive decision window extends into the first 10 weeks after spawning., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Published: 2023
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16. Coupling an ion chromatography to high resolution mass spectrometry (IC-MS) for the discovery of potentially prebiotic oligosaccharides in Chardonnay grape marc.

Author: Tian T, Rumachik N, Sinrod AJG, Barile D, and Liu Y
Subjects: Humans, Mass Spectrometry methods, Oligosaccharides analysis, Carbohydrates, Chromatography, High Pressure Liquid methods, Vitis
Abstract: Oligosaccharides are carbohydrates made of three to twenty monosaccharide units linked through glycosidic bonds. Emerging research into the potential prebiotic activity of oligosaccharides is creating opportunities to use industrial byproducts as value-added products. Grape marc is a residue left after winemaking and has been shown to provide health benefits to humans. In this study, we analyzed the oligosaccharides in Chardonnay grape marc by utilizing a hyphenated platform in which an ion chromatography (IC) system is coupled to an Orbitrap mass spectrometer (MS). With this platform, we obtained a structural library including 32 oligosaccharides with unique compositions of monosaccharides and 61 oligosaccharide structures. Notably, the ion chromatographic separation provided resolution of charged isomers while maintaining separation capacity for small, neutral oligosaccharides. High-quality tandem MS also facilitated the identification of oligosaccharides with structural modifications including methylation and the presence of sugar alditols and hexuronic acids. The data acquired by the IC-MS system were also compared with previously published LC-MS data. We found that these two platforms are largely complementary and, in combination, provide a more comprehensive characterization of oligosaccharides than either platform achieves alone., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier B.V. All rights reserved.)
Published: 2023
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17. Music and Speech Perception in Prelingually Deafened Young Listeners With Cochlear Implants: A Preliminary Study Using Sung Speech.

Author: Wheeler HJ, Hatch DR, Moody-Antonio SA, and Nie Y
Subjects: Auditory Perception, Humans, Pitch Perception, Speech, Cochlear Implantation, Cochlear Implants, Music, Speech Perception
Abstract: Purpose: In the context of music and speech perception, this study aimed to assess the effect of variation in one of two auditory attributes-pitch contour and timbre-on the perception of the other in prelingually deafened young cochlear implant (CI) users, and the relationship between pitch contour perception and two cognitive functions of interest., Method: Nine prelingually deafened CI users, aged 8.75-22.17 years, completed a melodic contour identification (MCI) task using stimuli of piano notes or sung speech with a fixed timbre (same word for each note) or a mixed timbre (different words for each note), a speech perception task identifying matrix-styled sentences naturally intonated or sung with a fixed pitch (same pitch for each word) or a mixed pitch (different pitches for each word), a forward digit span test indexing auditory short-term memory (STM), and the matrices section of the Kaufman Brief Intelligence Test-Second Edition indexing nonverbal IQ., Results: MCI was significantly poorer for the mixed timbre condition. Speech perception was significantly poorer for the fixed and mixed pitch conditions than for the naturally intonated condition. Auditory STM positively correlated with MCI at 2- and 3-semitone note spacings. Relative to their normal-hearing peers from a related study using the same stimuli and tasks, the CI participants showed comparable MCI at 2- or 3-semitone note spacing, and a comparable level of significant decrement in speech perception across three pitch contour conditions., Conclusion: Findings suggest that prelingually deafened CI users show similar trends of normal-hearing peers for the effect of variation in pitch contour or timbre on the perception of the other, and that cognitive functions may underlie these outcomes to some extent, at least for the perception of pitch contour., Supplemental Material: https://doi.org/10.23641/asha.21217937.
Published: 2022
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18. Efficient production of immunologically active Shigella invasion plasmid antigens IpaB and IpaH using a cell-free expression system.

Author: Kapoor N, Ndungo E, Pill L, Desalegn G, Berges A, Oaks EV, Fairman J, and Pasetti MF
Subjects: Animals, Antigens, Bacterial genetics, Bacterial Proteins genetics, Mice, Plasmids genetics, Shigella flexneri, Vaccine Development, Escherichia coli genetics, Shigella
Abstract: Shigella spp. invade the colonic epithelium and cause bacillary dysentery in humans. Individuals living in areas that lack access to clean water and sanitation are the most affected. Even though infection can be treated with antibiotics, Shigella antimicrobial drug resistance complicates clinical management. Despite decades of effort, there are no licensed vaccines to prevent shigellosis. The highly conserved invasion plasmid antigens (Ipa), which are components of the Shigella type III secretion system, participate in bacterial epithelial cell invasion and have been pursued as vaccine targets. However, expression and purification of these proteins in conventional cell-based systems have been challenging due to solubility issues and extremely low recovery yields. These difficulties have impeded manufacturing and clinical advancement. In this study, we describe a new method to express Ipa proteins using the Xpress +TM cell-free protein synthesis (CFPS) platform. Both IpaB and the C-terminal domain of IpaH1.4 (IpaH-CTD) were efficiently produced with this technology at yields > 200 mg/L. Furthermore, the expression was linearly scaled in a bioreactor under controlled conditions, and proteins were successfully purified using multimode column chromatography to > 95% purity as determined by SDS-PAGE. Biophysical characterization of the cell-free synthetized IpaB and IpaH-CTD using SEC-MALS analysis showed well-defined oligomeric states of the proteins in solution. Functional analysis revealed similar immunoreactivity as compared to antigens purified from E. coli. These results demonstrate the efficiency of CFPS for Shigella protein production; the practicality and scalability of this method will facilitate production of antigens for Shigella vaccine development and immunological analysis. KEY POINTS : • First report of Shigella IpaB and IpaH produced at high purity and yield using CFPS • CFPS-IpaB and IpaH perform similarly to E. coli-produced proteins in immunoassays • CFPS-IpaB and IpaH react with Shigella-specific human antibodies and are immunogenic in mice., (© 2021. The Author(s).)
Published: 2022
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19. Maternal opioid use disorder: Placental transcriptome analysis for neonatal opioid withdrawal syndrome.

Author: Radhakrishna U, Nath SK, Vishweswaraiah S, Uppala LV, Forray A, Muvvala SB, Mishra NK, Southekal S, Guda C, Govindamangalam H, Vargas D, Gardella WG, Crist RC, Berrettini WH, Metpally RP, and Bahado-Singh RO
Subjects: Analgesics, Opioid therapeutic use, Carrier Proteins, Female, Gene Expression Profiling, Humans, Infant, Infant, Newborn, Membrane Proteins, Placenta, Pregnancy, Neonatal Abstinence Syndrome complications, Neonatal Abstinence Syndrome drug therapy, Neonatal Abstinence Syndrome genetics, Opioid-Related Disorders drug therapy, Opioid-Related Disorders genetics
Abstract: Excessive prenatal opioid exposure may lead to the development of Neonatal Opioid Withdrawal Syndrome (NOWS). RNA-seq was done on 64 formalin-fixed paraffin-embedded placental tissue samples from 32 mothers with opioid use disorder, with newborns with NOWS that required treatment, and 32 prenatally unexposed controls. We identified 93 differentially expressed genes in the placentas of infants with NOWS compared to unexposed controls. There were 4 up- and 89 downregulated genes. Among these, 7 genes CYP1A1, APOB, RPH3A, NRXN1, LINC01206, AL157396.1, UNC80 achieved an FDR p-value of <0.01. The remaining 87 genes were significant with FDR p-value <0.05. The 4 upregulated, CYP1A1, FP671120.3, RAD1, RN7SL856P, and the 10 most significantly downregulated genes were RNA5SP364, GRIN2A, UNC5D, DMBT1P1, MIR3976HG, LINC02199, LINC02822, PANTR1, AC012178.1, CTNNA2. Ingenuity Pathway Analysis identified the 7 most likely to play an important role in the etiology of NOWS. Our study expands insights into the genetic mechanisms of NOWS development., (Copyright © 2021. Published by Elsevier Inc.)
Published: 2021
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20. Uncovering turbulent plasma dynamics via deep learning from partial observations.

Author: Mathews A, Francisquez M, Hughes JW, Hatch DR, Zhu B, and Rogers BN
Abstract: One of the most intensely studied aspects of magnetic confinement fusion is edge plasma turbulence which is critical to reactor performance and operation. Drift-reduced Braginskii two-fluid theory has for decades been widely applied to model boundary plasmas with varying success. Towards better understanding edge turbulence in both theory and experiment, we demonstrate that a physics-informed deep learning framework constrained by partial differential equations can accurately learn turbulent fields consistent with the two-fluid theory from partial observations of electron pressure which is not otherwise possible using conventional equilibrium models. This technique presents a paradigm for the advanced design of plasma diagnostics and validation of magnetized plasma turbulence theories in challenging thermonuclear environments.
Published: 2021
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21. Global Theory of Microtearing Modes in the Tokamak Pedestal.

Author: Larakers JL, Curie M, Hatch DR, Hazeltine RD, and Mahajan SM
Abstract: The pedestal of H-mode tokamaks displays strong magnetic fluctuations correlated with the evolution of the electron temperature. The microtearing mode (MTM), a temperature-gradient-driven instability that alters magnetic topology, is compatible with these observations. Here we extend the conventional theory of the MTM to include the global variation of the temperature and density profiles. The offset between the rational surface and the location of the pressure gradient maximum (μ) emerges as a crucial parameter for MTM stability. The extended theory matches observations on the Joint European Torus tokamak.
Published: 2021
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22. Importance of gyrokinetic exact Fokker-Planck collisions in fusion plasma turbulence.

Author: Pan Q, Ernst DR, and Hatch DR
Abstract: Gyrokinetic simulations of turbulence are fundamental to understanding and predicting particle and energy loss in magnetic fusion devices. Previous works have used model collision operators with approximate field-particle terms of unknown accuracy and/or have neglected collisional finite Larmor radius effects. This work moves beyond models to demonstrate important corrections using a gyrokinetic Fokker-Planck collision operator with the exact field-particle terms, in realistic simulations of turbulence in magnetically confined fusion plasmas. The exact operator shows significant corrections for temperature-gradient-driven trapped electron mode turbulence and zonal flow damping, and for microtearing modes in a Joint European Torus pedestal under ITER-like wall conditions. Analysis of the corrections using parameter scans motivates an accurate model which closely reproduces the exact results while reducing computational demands.
Published: 2021
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23. Elevated plasma triglycerides and growth rate are early indicators of reproductive status in post-spawning female steelhead trout ( Oncorhynchus mykiss ).

Author: Jenkins LE, Pierce AL, Graham ND, Medeiros LR, Hatch DR, and Nagler JJ
Abstract: Many iteroparous fishes spawn after skipping one or more yearly cycles, which impacts recruitment estimates used for fisheries management and conservation. The physiological mechanisms underlying the development of consecutive and skip spawning life histories in fishes are not well understood. In salmonids, lipid energy reserves and/or growth are thought to regulate the initiation of reproductive maturation during a critical period ~1 year prior to spawning. The fasting spawning migration of summer-run steelhead trout ( Oncorhynchus mykiss ) results in significant depletion of energy reserves during the proposed critical period for repeat spawning. To determine whether and when lipid energy reserves and growth influence repeat spawning, measures of lipid energy reserves, growth rate and reproductive development were tracked in female steelhead trout from first to second spawning as a consecutive or skip spawner in captivity. Plasma triglyceride (TG) levels and growth rate were elevated by 10 weeks after spawning in reproductive (i.e. consecutive spawning) versus non-reproductive (i.e. skip spawning) individuals. Muscle lipid (ML) levels, condition factor and plasma estradiol levels increased at later time points. The early differences in plasma TG levels and increases in growth rate are attributable to differential rates of feeding and assimilation between the groups following spawning. A year after spawning, plasma TG levels, MLs and growth rate decreased in consecutive spawners, attributable to transfer of lipid reserves into the ovary. During the year prior to second spawning, energy reserves and plasma estradiol levels were higher in reproductive skip spawners versus consecutive spawners, reflecting the energy deficit after first spawning. These results suggest that the decision to initiate ovarian recrudescence occurs by 10 weeks after first spawning and are consistent with the differences in energy reserves acquired following spawning being a consequence of that decision. This information will increase the success of conservation projects reconditioning post-spawning summer-run steelhead trout.
Published: 2019
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24. Stellarator Turbulence: Subdominant Eigenmodes and Quasilinear Modeling.

Author: Pueschel MJ, Faber BJ, Citrin J, Hegna CC, Terry PW, and Hatch DR
Abstract: Owing to complex geometry, gyrokinetic simulations in stellarator geometry produce large numbers of subdominant unstable and stable, near-orthogonal eigenmodes. Here, results based on the full eigenmode spectrum in stellarator geometry are presented for the first time. In the nonlinear state of a low-magnetic-shear ion-temperature-gradient-driven case, a multitude of these modes are active and imprint the system. Turbulent frequency spectra are broadband as a consequence, in addition to a nonlinear, narrow signature at electron frequencies. It is shown that successful quasilinear, mixing-length transport modeling is possible in stellarators, where it is essential to account for all subdominant unstable modes.
Published: 2016
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25. Acoustically evoked auditory change complex in children with auditory neuropathy spectrum disorder: a potential objective tool for identifying cochlear implant candidates.

Author: He S, Grose JH, Teagle HF, Woodard J, Park LR, Hatch DR, Roush P, and Buchman CA
Subjects: Adolescent, Child, Child, Preschool, Cochlear Implantation methods, Feasibility Studies, Female, Hearing Loss, Central rehabilitation, Humans, Infant, Male, Speech Perception physiology, Evoked Potentials, Auditory physiology, Hearing Loss, Central physiopathology, Patient Selection
Abstract: Objectives: The overall aim of the study was to evaluate the feasibility of using electrophysiological measures of the auditory change complex (ACC) to identify candidates for cochlear implantation in children with auditory neuropathy spectrum disorder (ANSD). To achieve this overall aim, this study (1) assessed the feasibility of measuring the ACC evoked by temporal gaps in a group of children with ANSD across a wide age range and (2) investigated the association between gap detection thresholds (GDTs) measured by the ACC recordings and open-set speech-perception performance in these subjects., Design: Nineteen children with bilateral ANSD ranging in age between 1.9 and 14.9 years (mean: 7.8 years) participated in this study. Electrophysiological recordings of the auditory event-related potential (ERP), including the onset ERP response and the ACC, were completed in all subjects and open-set speech perception was evaluated for a subgroup of 16 subjects. For the ERP recordings, the stimulus was a Gaussian noise presented through ER-3A insert earphones to the test ear. Two stimulation conditions were used. In the "control condition," the stimulus was an 800-msec Gaussian noise. In the "gapped condition," the stimuli were two noise segments, each being 400 msec in duration, separated by one of five gaps (i.e., 5, 10, 20, 50, or 100 msec). The interstimulation interval was 1200 msec. The aided open-set speech perception ability was assessed using the Phonetically Balanced Kindergarten (PBK) word lists presented at 60 dB SPL using recorded testing material in a sound booth. For speech perception tests, subjects wore their hearing aids at the settings recommended by their clinical audiologists. For a subgroup of five subjects, psychophysical GDTs for the Gaussian noise were also assessed using a three-interval, three-alternative forced-choice procedure., Results: Responses evoked by the onset of the Gaussian noise (i.e., onset responses) were recorded in all stimulation conditions from all subjects tested in this study. The presence/absence, peak latency and amplitude, and response width of the onset response did not correlate with aided PBK word scores. The objective GDTs measured with the ACC recordings from 17 subjects ranged from 10 to 100 msec. The ACC was not recorded from two subjects for any gap durations tested in this study. There was a robust negative correlation between objective GDTs and aided PBK word scores. In general, subjects with prolonged objective GDTs showed low-aided PBK word scores. GDTs measured using electrophysiological recordings of the ACC correlated well with those measured using psychophysical procedures in four of five subjects who were evaluated using both procedures., Conclusions: The clinical application of the onset response in predicting open-set speech-perception ability is relatively limited in children with ANSD. The ACC recordings can be used to objectively evaluate temporal resolution abilities in children with ANSD having no severe comorbidities, and who are older than 1.9 years. The ACC can potentially be used as an objective tool to identify poor performers among children with ANSD using properly fit amplification, and who are thus, cochlear implant candidates.
Published: 2015
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26. Subdominant modes in zonal-flow-regulated turbulence.

Author: Makwana KD, Terry PW, Pueschel MJ, and Hatch DR
Abstract: From numerical solutions of a gyrokinetic model for ion temperature gradient turbulence it is shown that nonlinear coupling is dominated by three-wave interactions that include spectral components of the zonal flow and damped subdominant modes. Zonal flows dissipate very little energy injected by the instability, but facilitate its transfer from the unstable mode to dissipative subdominant modes, in part due to the small frequency sum of such triplets. Although energy is transferred to higher wave numbers, consistent with shearing, a large fraction is transferred to damped subdominant modes within the instability range. This is a new aspect of regulation of turbulence by zonal flows.
Published: 2014
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27. Gap detection measured with electrically evoked auditory event-related potentials and speech-perception abilities in children with auditory neuropathy spectrum disorder.

Author: He S, Grose JH, Teagle HF, Woodard J, Park LR, Hatch DR, and Buchman CA
Subjects: Adolescent, Child, Child, Preschool, Cochlear Implants, Electric Stimulation methods, Feasibility Studies, Female, Humans, Male, Reproducibility of Results, Auditory Threshold physiology, Electric Stimulation instrumentation, Evoked Potentials, Auditory physiology, Hearing Loss, Central physiopathology, Speech Perception physiology
Abstract: Objectives: This study aimed (1) to investigate the feasibility of recording the electrically evoked auditory event-related potential (eERP), including the onset P1-N1-P2 complex and the electrically evoked auditory change complex (EACC) in response to temporal gaps, in children with auditory neuropathy spectrum disorder (ANSD); and (2) to evaluate the relationship between these measures and speech-perception abilities in these subjects., Design: Fifteen ANSD children who are Cochlear Nucleus device users participated in this study. For each subject, the speech-processor microphone was bypassed and the eERPs were elicited by direct stimulation of one mid-array electrode (electrode 12). The stimulus was a train of biphasic current pulses 800 msec in duration. Two basic stimulation conditions were used to elicit the eERP. In the no-gap condition, the entire pulse train was delivered uninterrupted to electrode 12, and the onset P1-N1-P2 complex was measured relative to the stimulus onset. In the gapped condition, the stimulus consisted of two pulse train bursts, each being 400 msec in duration, presented sequentially on the same electrode and separated by one of five gaps (i.e., 5, 10, 20, 50, and 100 msec). Open-set speech-perception ability of these subjects with ANSD was assessed using the phonetically balanced kindergarten (PBK) word lists presented at 60 dB SPL, using monitored live voice in a sound booth., Results: The eERPs were recorded from all subjects with ANSD who participated in this study. There were no significant differences in test-retest reliability, root mean square amplitude or P1 latency for the onset P1-N1-P2 complex between subjects with good (>70% correct on PBK words) and poorer speech-perception performance. In general, the EACC showed less mature morphological characteristics than the onset P1-N1-P2 response recorded from the same subject. There was a robust correlation between the PBK word scores and the EACC thresholds for gap detection. Subjects with poorer speech-perception performance showed larger EACC thresholds in this study., Conclusions: These results demonstrate the feasibility of recording eERPs from implanted children with ANSD, using direct electrical stimulation. Temporal-processing deficits, as demonstrated by large EACC thresholds for gap detection, might account in part for the poor speech-perception performances observed in a subgroup of implanted subjects with ANSD. This finding suggests that the EACC elicited by changes in temporal continuity (i.e., gap) holds promise as a predictor of speech-perception ability among implanted children with ANSD.
Published: 2013
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28. Transition between saturation regimes of gyrokinetic turbulence.

Author: Hatch DR, Jenko F, Bañón Navarro A, and Bratanov V
Abstract: A gyrokinetic model of ion temperature gradient driven turbulence in magnetized plasmas is used to study the injection, nonlinear redistribution, and collisional dissipation of free energy in the saturated turbulent state over a broad range of driving gradients and collision frequencies. The dimensionless parameter L(T)/L(C), where L(T) is the ion temperature gradient scale length and L(C) is the collisional mean free path, is shown to parametrize a transition between a saturation regime dominated by nonlinear transfer of free energy to small perpendicular (to the magnetic field) scales and a regime dominated by dissipation at large scales in all phase space dimensions.
Published: 2013
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29. Nonuniversal power-law spectra in turbulent systems.

Author: Bratanov V, Jenko F, Hatch DR, and Wilczek M
Abstract: Turbulence is generally associated with universal power-law spectra in scale ranges without significant drive or damping. Although many examples of turbulent systems do not exhibit such an inertial range, power-law spectra may still be observed. As a simple model for such situations, a modified version of the Kuramoto-Sivashinsky equation is studied. By means of semianalytical and numerical studies, one finds power laws with nonuniversal exponents in the spectral range for which the ratio of nonlinear and linear time scales is (roughly) scale independent.
Published: 2013
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30. Extreme heat fluxes in gyrokinetic simulations: a new critical β.

Author: Pueschel MJ, Terry PW, Jenko F, Hatch DR, Nevins WM, Görler T, and Told D
Abstract: A hitherto unexplained feature of electromagnetic simulations of ion temperature gradient turbulence is the apparent failure of the transport levels to saturate for certain parameters; this effect, termed here nonzonal transition, has been referred to as the high-β runaway. The resulting large heat fluxes are shown to be a consequence of reduced zonal flow activity, brought on by magnetic field perturbations shorting out flux surfaces.
Published: 2013
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31. Facilitating dynamo action via control of large-scale turbulence.

Author: Limone A, Hatch DR, Forest CB, and Jenko F
Abstract: The magnetohydrodynamic dynamo effect is considered to be the major cause of magnetic field generation in geo- and astrophysical systems. Recent experimental and numerical results show that turbulence constitutes an obstacle to dynamos; yet its role in this context is not totally clear. Via numerical simulations, we identify large-scale turbulent vortices with a detrimental effect on the amplification of the magnetic field in a geometry of experimental interest and propose a strategy for facilitating the dynamo instability by manipulating these detrimental "hidden" dynamics.
Published: 2012
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32. Origin of magnetic stochasticity and transport in plasma microturbulence.

Author: Hatch DR, Pueschel MJ, Jenko F, Nevins WM, Terry PW, and Doerk H
Abstract: Nonlinear excitation of linearly stable microtearing modes--with zonal modes acting as a catalyst--is shown to be responsible for the near-ubiquitous magnetic stochasticity and associated electromagnetic electron heat transport in electromagnetic gyrokinetic simulations of plasma microturbulence.
Published: 2012
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33. Gyrokinetic microtearing turbulence.

Author: Doerk H, Jenko F, Pueschel MJ, and Hatch DR
Abstract: The nonlinear dynamics of microtearing modes in standard tokamak plasmas are investigated by means of ab initio gyrokinetic simulations. The saturation levels of the magnetic field fluctuations can be understood in the framework of a balance between (small poloidal wave number) linear drive and small-scale dissipation. The resulting heat transport is dominated by the electron magnetic component, and the transport levels are found to be experimentally relevant. Microtearing modes thus constitute another candidate for explaining turbulent transport in such toroidal systems.
Published: 2011
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34. Saturation of gyrokinetic turbulence through damped eigenmodes.

Author: Hatch DR, Terry PW, Jenko F, Merz F, and Nevins WM
Abstract: In the context of toroidal gyrokinetic simulations, it is shown that a hierarchy of damped modes is excited in the nonlinear turbulent state. These modes exist at the same spatial scales as the unstable eigenmodes that drive the turbulence. The larger amplitude subdominant modes are weakly damped and exhibit smooth, large-scale structure in velocity space and in the direction parallel to the magnetic field. Modes with increasingly fine-scale structure are excited to decreasing amplitudes. In aggregate, damped modes define a potent energy sink. This leads to an overlap of the spatial scales of energy injection and peak dissipation, a feature that is in contrast with more traditional turbulent systems.
Published: 2011
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35. Cochlear implantation in children with auditory neuropathy spectrum disorder.

Author: Teagle HF, Roush PA, Woodard JS, Hatch DR, Zdanski CJ, Buss E, and Buchman CA
Subjects: Adolescent, Auditory Diseases, Central surgery, Child, Child, Preschool, Comorbidity, Databases, Factual, Evoked Potentials, Auditory, Follow-Up Studies, Hearing, Hearing Loss, Bilateral epidemiology, Hearing Loss, Bilateral surgery, Hearing Loss, Bilateral therapy, Humans, Infant, Longitudinal Studies, Postoperative Complications epidemiology, Premature Birth epidemiology, Prospective Studies, Speech Perception, Treatment Outcome, Vestibulocochlear Nerve Diseases surgery, Young Adult, Auditory Diseases, Central epidemiology, Auditory Diseases, Central therapy, Cochlear Implantation, Vestibulocochlear Nerve Diseases epidemiology, Vestibulocochlear Nerve Diseases therapy
Abstract: Objective: To report the patient's characteristics, preoperative audiological profiles, surgical outcomes, and postoperative performance for children with auditory neuropathy spectrum disorder (ANSD) who ultimately received cochlear implants (CIs)., Design: Prospective, longitudinal study of children with ANSD who received CIs after a stepwise management protocol that included electrophysiologic and medical assessment, documentation of behavioral audiometric thresholds and subsequent fitting of amplification according to Desired Sensation Level targets, auditory-based intervention with careful monitoring of skills development and communication milestones, and finally implantation when progress with the use of acoustic amplification was insufficient., Results: Of 140 children with ANSD, 52 (37%) received CIs in their affected ears (mean duration of use of 41 mos). Many of these children were born prematurely (42%) and impacted by a variety of medical comorbidities. More than one third (38%) had abnormal findings on preoperative magnetic resonance imaging of the brain and inner ear, and 81% had a greater than severe (>70 dB HL) degree of hearing loss before implantation. Although 50% of the implanted children with ANSD demonstrated open-set speech perception abilities after implantation, nearly 30% of them with >6 months of implant experience were unable to participate in this type of testing because of their young age or developmental delays. No child with cochlear nerve deficiency (CND) in their implanted ear achieved open-set speech perception abilities. In a subgroup of children, good open-set speech perception skills were associated with robust responses elicited on electrical-evoked intracochlear compound action potential testing when this assessment was possible., Conclusions: This report shows that children with ANSD who receive CIs are a heterogeneous group with a wide variety of impairments. Although many of these children may ultimately benefit from implantation, some will not, presumably because of a lack of electrical-induced neural synchronization, the detrimental effects of their other associated conditions, or a combination of factors. When preoperative magnetic resonance imaging reveals central nervous system pathology, this portends a poor prognosis for the development of open-set speech perception, particularly when CND is evident. These results also show that electrical-evoked intracochlear compound action potential testing may help identify those children who will develop good open-set speech perception. Instead of recommending CI for all children with electrophysiologic evidence of ANSD, the stepwise management procedure described herein allows for the identification of children who may benefit from amplification, those who are appropriate candidates for cochlear implantation, and those who, because of bilateral CND, may not be appropriate candidates for either intervention.
Published: 2010
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36. Detection of spectrally complex signals in comodulated maskers: effect of temporal fringe.

Author: Grose JH, Hall JW 3rd, Buss E, and Hatch DR
Subjects: Acoustic Stimulation, Adult, Auditory Threshold physiology, Discrimination, Psychological physiology, Humans, Middle Aged, Auditory Perception physiology, Perceptual Masking physiology
Abstract: This study tested the hypothesis that masking release for a complex signal under conditions where signal energy is present in all frequency regions occupied by the masker is attributable to an across-frequency-channel comodulation masking release (CMR) process. The approach was to identify a signature CMR trait, and to then determine if that trait was associated with the detection advantage for complex signals. The selected trait was the decline of CMR in the presence of a random temporal fringe. In experiment 1, a masking release was observed for a four-component harmonic signal presented in a comodulated masker, and this masking release was diminished by the random temporal fringe. A similar effect was observed in experiment 2 for a four-component inharmonic signal. These results support the hypothesis that a CMR can be measured for a complex signal even when there is substantial spectral overlap between the signal and its comodulated masker. This finding has consequences for CMR models since it demonstrates that the presence of "signal-free" cue bands is not a prerequisite for CMR, and that the presence of comodulation during the signal window is not sufficient to result in CMR.
Published: 2005
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37. Perceptual consequences of peripheral hearing loss: do edge effects exist for abrupt cochlear lesions?

Author: Buss E, Hall JW 3rd, Grose JH, and Hatch DR
Subjects: Acoustic Stimulation, Adult, Auditory Threshold physiology, Case-Control Studies, Female, Humans, Male, Middle Aged, Models, Biological, Psychoacoustics, Auditory Perception physiology, Hearing Loss, High-Frequency physiopathology
Abstract: There is a growing body of research that shows evidence of central neural reorganization in response to lesions in the auditory periphery, even if the lesions occur in maturity. This reorganization consists of an increased neural representation of frequencies corresponding to the edge frequency of the lesion. Data were collected to determine whether this over-representation might have consequences for human perception. The hypothesis was that increased central representation might increase acuity on some psychophysical tasks performed at the edge frequency. Tasks included frequency sweep detection (for tones), intensity discrimination (for 100-Hz-wide bands of noise and tones), gap detection and gap discrimination (both for 100-Hz-wide bands of noise). Results from observers with steeply sloping hearing losses were compared with results from normal-hearing observers performing these tasks with masking noise generated to simulate steeply sloping hearing loss. None of these data provide compelling evidence for the hypothesized edge effect. A 40-Hz following response to tone bursts was collected from a subset of the hearing-impaired observers in an attempt to confirm the animal physiology findings of neural over-representation of the edge frequency. No edge-frequency effect was noted in the results, though there was a non-significant tendency for one of the hearing-impaired observers to show shorter latency of response.
Published: 1998
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38. Effects of masker gating for signal detection in unmodulated and modulated bandlimited noise.

Author: Hall JW 3rd, Grose JH, and Hatch DR
Subjects: Adult, Auditory Threshold, Female, Humans, Male, Noise, Perceptual Masking, Signal Detection, Psychological
Abstract: Thresholds for a 400-ms 1000-Hz pure-tone signal were obtained as a function of masking noise bandwidth for unmodulated and square wave modulated masking noise. Rates of modulation were 10 and 40 Hz. Noise bandwidths were 128 Hz, 387 Hz, 921 Hz, and 1505 Hz. The masking noise was either continuous or gated on and off with the signal. In general, signal thresholds were relatively constant as a function of noise bandwidth in unmodulated noise, and improved as a function of increasing noise bandwidth in modulated noise. Noise gating had little or no effect on signal threshold in unmodulated noise. At the 10-Hz modulation rate, signal thresholds were somewhat higher in gated than in continuous noise at relatively narrow noise bandwidths, but thresholds were similar in gated and continuous noise for relatively wide noise bandwidths. At bandwidths of 387, 921, and 1505 Hz, comodulation masking release (CMR) was calculated as the unmodulated noise threshold minus the modulated noise threshold, corrected by the difference between the unmodulated noise threshold and the modulated noise threshold at the 128-Hz bandwidths. At wide masker bandwidth, CMRs were higher for gated noise than for continuous noise. This was due almost entirely to the threshold gating effect found in the 128-Hz bandwidth condition. These results suggested that there was a within-channel effect for gated noise thresholds to be higher than continuous noise thresholds, but essentially no across-channel effect of gating. At the 40-Hz modulation rate, signal thresholds were similar for gated and continuous noise at all noise bandwidths. There was a very small but significant' effect for the gated noise threshold to be lower than the continuous noise threshold at the widest noise bandwidth. It was speculated that this effect may be related to a decrease in sensitivity to modulation with continuous stimulation. In general, effects of gating appear to be small or absent for across-channel masking release in broadband modulated masking noise.
Published: 1996
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39. Gold vapor laser versus tunable argon-dye laser for endobronchial photodynamic therapy.

Author: McCaughan JS Jr, Barabash RD, Hatch DR, and McMahon DC
Subjects: Argon, Bronchial Neoplasms pathology, Bronchoscopy, Humans, Antineoplastic Agents therapeutic use, Bronchial Neoplasms drug therapy, Laser Therapy, Photochemotherapy, Triazenes therapeutic use
Abstract: Background and Objective: To compare the effectiveness of a gold vapor pulsed laser versus an argon dye continuous wave laser system in decreasing the amount of obstruction caused by endobronchial tumors when they are treated with photodynamic therapy (PDT)., Study Design/materials and Methods: The percentage of endobronchial obstruction from tumors before and at the end of PDT, and before and at the end of toilet bronchoscopy of 96 sites treated with light generated by a Spectra Physics tunable argon dye system were compared to those of 17 sites treated with light generated by a gold vapor laser. All patients were injected intravenously with 60 mg of dihematoporphyrin ethers per square meter of body surface. All treatments were done with a power density of 500 mW/CF and a light dose of 400 J/CF delivered from cylinder diffusing fibers., Results: Paired Student's t-tests and Wilcoxon signed ranks tests showed significant decreases in the percentage of endobronchial obstruction due to PDT regardless of the laser used. Unpaired Student's t-tests and Mann-Whitney U statistical comparisons showed no significant difference between the two lasers in the percentage decrease at PDT, percentage increase from exudate seen at toilet bronchoscopy, nor the percentage decrease at the end of the toilet bronchoscopy from that before PDT., Conclusion: We found no statistically significant difference in the decrease in the amount of endobronchial tumor obstruction obtained when the light for treatment was generated by a pulsed gold vapor or a continuous wave argon dye laser system.
Published: 1996
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40. Comodulation masking release (CMR): effects of gating as a function of number of flanking bands and masker bandwidth.

Author: Hatch DR, Arné BC, and Hall JW 3rd
Subjects: Adult, Differential Threshold, Humans, Noise, Auditory Perception, Perceptual Masking
Abstract: Normal-hearing subjects participated in two CMR experiments. For experiment 1, two, three, five or nine 20-Hz-wide comodulated flanking bands were presented continuously or gated simultaneously with a 2000-Hz signal. The signal had a duration of 400 ms. Larger CMRs were obtained as the number of flanking bands increased for both the continuous and gated conditions. For fewer number of bands, the average CMR for continuous noise was substantially larger than for gated noise. As the number of bands increased, CMR increased more for gated than for continuous noise, and the difference between CMRs for gated and continuous noise decreased. Experiment 2 involved detecting a 400-ms 1000-Hz pure-tone signal in a seven-band comodulated noise complex. The noise bands, presented continuously or gated with the signal, were either 10, 20, 40, or 80 Hz wide. Larger CMRs were observed for continuous maskers and for smaller masker bandwidths; however, the effect of gating did not change significantly across bandwidth. The results of the first experiment indicate that the effects of gating on CMR are minimized when the number of auditory channels providing information is large. The results of the second experiment indicate that this effect is not simply a function of the large CMR magnitude obtained with a large number of flanking bands.
Published: 1995
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41. Zung, Beck, and Hamilton Rating Scales as measures of treatment outcome: a meta-analytic comparison.

Author: Lambert MJ, Hatch DR, Kingston MD, and Edwards BC
Subjects: Follow-Up Studies, Humans, Research Design, Depressive Disorder therapy, Personality Inventory, Psychiatric Status Rating Scales
Published: 1986
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