3 results on '"Hastings, KEM"'
Search Results
2. 1-03 Role of Activin A in human cancer cachexia (ACTICA study)
- Author
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Baracos, Vickie, Muscaritoli, Maurizio, Aversa, Zaira, Rossi Fanelli, Filippo, Loumaye, A, de Barsy, M, Nachit, M, Frateur, L, Lause, P, Van Maanen, A, Thissen, JP, Awasthi, R, Gillis, C, Liberman, S, Stein, B, Charlebois, P, Carli, F, Ahmad, Sultan, Chiche, Dan, Reza Kazemi-Bajestani, Seyyed Mohammad, Becher, Harald, Venner, Peter, North, Scott, Vickie, Baracos, Li, Yi-Ping, Zhang, Guohua, Ma, Jennifer, Hall, Derek, Patel, Devang, Robinson, Samantha, Di Marco, Sergio, Gallouzi, Imed-Eddine, Sartori, Roberta, Penna, Fabio, Costelli, Paola, Sandri, Marco, Gregorevic, Paul, Toth, Michael J, Miller, Mark S, Callahan, Damien M, Couch, Marion E, Dittus, Kim, Sharma, Mridula, Argilés, Josep M, Bedard, N, Wiles, B, Jammoul, S, Miao, M, Wykes, L, Coyne, E, Hallauer, PL, Hastings, KEM, Stretch, C, Baracos, VE, Chevalier, S, Wing, SS, Marchildon, François, Lala, Neena, St-Louis, Catherine, Wiper-Bergeron, Nadine, Santos Silva, Kleiton Augusto, Dong, Jiangling, Tweardy, David J, Mitch, William E, Zhang, Liping, Hall, Derek T, Ma, Jennifer F, Griss, Takla, Jones, Russell G, Marco, Sergio Di, Marks, Daniel L, Rudnicki, Michael A, Laine, Aaron, Narayanan, Sriram, Choy, Hak, Girard, Luc, Gazdar, Adi, Minna, John, Infante, Rodney, Iyengar, Puneeth, Petruzzelli, Michele, Schweiger, Martina, Rincon, Mercedes, Robertson, Graham, Zechner, Rudolf, Wagner, Erwin F, Pin, Fabrizio, Costamagna, Domiziana, Camperi, Andrea, Sampaolesi, Maurilio, He, Wei, Talbert, Erin, Londhe, Priya, Bloomston, Mark, Croce, Carlo, Guttridge, Denis, Breit, Samuel N, Tsai, Vicky WW, Manandhar, Rakesh, Lin, Shu, Sainsbury, Amanda, Brown, David A, Ferrara, Michele, Reano, Simone, Angelino, Elia, Sabry, Omar, Filigheddu, Nicoletta, Graziani, Andrea, Tsoli, Maria, Allen, John, Taylor, Ryland, Scwheiger, Martina, Swarbrick, Michael M, Ehteda, Anahid, Miekle, Peter, Molloy, Mark, Waning, David L, Mohammad, Khalid S, Reiken, Steven, Xie, Wenjun, Marks, Andrew R, Guise, Theresa A, Moya, Rosita, Zhao, Chunfang, Davies, Joanna D, Carson, James, Everett Couch, Marion, Stecher, Michael, El Mouelhi, Mohamed, Tseng, Yu-Chou, Kulp, Samuel K, Lai, I-Lu, Hsu, En-Chi, He, Wei A, Frankhouser, David E, Yan, Pearlly S, Mo, Xiaokui, Lesinski, Gregory B, Marcucci, Guido, Guttridge, Denis C, Bekaii-Saab, Tanios, Chen, Ching-Shih, Haddad, AHI Al, Al-Azwani, EK, Mahamoud, Y, Safi, F, Salhat, H El, Malek, JA, Adrian, TE, Fearon, K, Temel, J, Currow, D, Gleich, L, Friend, J, Abernethy, A, Garcia, Jose M, Dubé, A, Patoine, D, Lemire, BB, Thériault, M-E, Ribeiro, F, Debigaré, R, Maltais, F, Smuder, Ashley J, Min, Kisuk, Kwon, Oh-Sung, Wiggs, Michael P, Sollanenk, Kurt J, Christou, Demetra D, Yoo, Jeung-Ki, Hwang, Moon-Hyon, Szeto, Hazel H, Kavazis, Andreas N, Powers, Scott K, Kroenke, Candyce H, Meyerhardt, Jeffrey A, Kwan, Marilyn L, Prado, Carla, Xiao, Jingjie, Weltzien, Erin, Castillo, Adrienne, Caan, Bette J, Guan, Chen, Giles, Kaitlin, Wing, Simon, Mazurak, Vera, Jagoe, R Thomas, Wiles, Benjamin, Miao, Miao, Coyne, Erin, Larose, Louise, Cybulsky, Andrey V, Wing, Simon S, Marino, Francesco Elia, Risbridger, Gail, Gold, Elspeth, Segatto, Marco, Fittipaldi, Raffaella, Caretti, Giuseppina, Lee, Hwabin, Fu, Dechen, Dwarkasing, JT, Boekschoten, MV, Argilès, JM, van Dijk, M, Busquets, S, Penna, F, Toledo, M, Laviano, A, Witkamp, RF, van Norren, K, Bédard, Nathalie, Plourde, Marie, Chevalier, Stéphanie, Lala-Tabbert, Neena, Marchildon, Francois, Torabi, S, Glare, P, Plodkowski, A, Margaron, Yoran, Fernandes, Mathieu, Morales, Delphine, Poydenot, Pauline, Menager, Pauline, Fuchs, Alexandra, Degot, Sébastien, Calore, Federica, Canella, Alessandro, Croce, Carlo M, Srinivasan, Kalayarasan, Pulliparracharuvil, Suprabha, Meyer, Jeffrey, Scherer, Philipp E, Kambadur, Ravi, Martinelli, Giulia B, Talamini, Laura, Previdi, Sara, Piccirillo, Rosanna, Jafri, Syed H, Previgliano, Carlos, Khandelwal, Keerti, Shi, Runhua, Mills, Glenn, Amato, Robert, Coats, Valérie, Ribeiro, Fernanda, Tremblay, Lise, Lacasse, Yves, Maltais, François, Saey, Didier, AL Vigano, Antonio, Ciutto, Lorella, Tomasso, Jonathan Di, Kilgour, Robert D, Morais, José A, Borod, Manuel, Almasud, A, Giles, K, Baracos, V, Guan, L, Mazurak, V, Khanuja, Jasleen, Gresham, Gillian, Osipov, Arsen, Tan, Carlyn-Rose, Tuli, Richard, Hendifar, Andrew, Narasimhan, Ashok, Greiner, Russell, Yasui, Yutaka, Bathe, Oliver, Fearon, Kenneth, Damaraju, Sambasivarao, Banh, Taylor, Kliewer, Kara, Hsiao, Yung-Hsuan, Belury, Martha A, Caan, Bette, Quesenberry, Charles, Kwan, Marilyn, Prado, Carla MM, Baracos, Vickie E, Birdsell, Laura, Stuyckens, Kim, Park, Youn Choi, Parekh, Trilok, Sawyer, Michael B, Wu, C, Fernandez, SA, Criswell, T, Chidiac, T, Guttridge, D, Villalona-Calero, M, Bekaii-Saab, T, Khan, Sarah, ALVigano, Antonio, Matos-Neto, EM, Figuerêdo, RG, Camargo, RG, Lima, JDCC, Alves, MJ, Riccardi, D, Alcantara, PS, Pinhata, J, Maximiano, L, Seelaender, M, Lamarche, Émilie, Au, Ernie D, Desai, Aditya P, Koniaris, Leonidas G, Zimmers, Teresa A, Manring, Heather, Weisleder, Noah, Okamura, Heidi, Frankhouser, David, Yan, Pearlly, Tomasso, Jonathan di, Fabbro, Egidio G Del, Davis, Mellar P, Fearon, Kenneth CH, Jatoi, Aminah A, Vigano, Antonio, Putman, Ted, Kezhuo, Zhang, Sladek, Robert, Enjiu, LM, Gomes, SP, Matos-Neto, E, Rossi-Fanneli, F, Seelaender, MC, Ebadi, Maryam, Mazurak, Vera C, Bhatia, Nikita, Padliya, Neerav D, Stadler, Volker, Dariani, Maghsoud, Hariri, Robert J, Parker, Valorie A, Matthews, Ryan R, Bonetto, Andrea, Puppa, Melissa, Kang, Kyung Shin, Mohammed, Khalid S, Robling, Alexander G, Toledo, Míriam, Oliva, Francesc, Luque, Melania, Betancourt, Angelica, Marmonti, Enrica, López-Soriano, Francisco J, Busquets, Sílvia, Theal, Rebecca, Jiang, Heng, Sanchez, Anthony, Hussain, Sabah N, Serpe, R, Madeddu, C, Gudiño, V, Gabba, S, Antoni, G, Macciò, A, and Banni, S
- Subjects
Abstracts - Published
- 2015
3. Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy.
- Author
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Janice Sánchez B, Tremblay AK, Leduc-Gaudet JP, Hall DT, Kovacs E, Ma JF, Mubaid S, Hallauer PL, Phillips BL, Vest KE, Corbett AH, Kontoyiannis DL, Hussain SNA, Hastings KEM, Di Marco S, and Gallouzi IE
- Subjects
- Animals, Cell Line, Cell Line, Tumor, Cross-Sectional Studies, ELAV-Like Protein 1 genetics, Gene Expression Regulation genetics, Gene Expression Regulation physiology, Immunohistochemistry, Male, Mice, Mice, Knockout, ELAV-Like Protein 1 metabolism, Muscle, Skeletal metabolism, Muscular Atrophy etiology, Muscular Atrophy metabolism, Neoplasms complications
- Abstract
The master posttranscriptional regulator HuR promotes muscle fiber formation in cultured muscle cells. However, its impact on muscle physiology and function in vivo is still unclear. Here, we show that muscle-specific HuR knockout (muHuR-KO) mice have high exercise endurance that is associated with enhanced oxygen consumption and carbon dioxide production. muHuR-KO mice exhibit a significant increase in the proportion of oxidative type I fibers in several skeletal muscles. HuR mediates these effects by collaborating with the mRNA decay factor KSRP to destabilize the PGC-1α mRNA. The type I fiber-enriched phenotype of muHuR-KO mice protects against cancer cachexia-induced muscle loss. Therefore, our study uncovers that under normal conditions HuR modulates muscle fiber type specification by promoting the formation of glycolytic type II fibers. We also provide a proof-of-principle that HuR expression can be targeted therapeutically in skeletal muscles to combat cancer-induced muscle wasting.
- Published
- 2019
- Full Text
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