1. Impact of antibiotic prophylaxis and conditioning modalities in per-oral endoscopic myotomy for esophageal motor disorders
- Author
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Audrey Hastier-De Chelle, Philippe Onana-Ndong, Raphaël Olivier, Imad Bentellis, Mathieu Pioche, Jérôme Rivory, Jean Michel Gonzalez, Laurent Bailly, Thierry Piche, Thierry Ponchon, Charlène Brochard, Emmanuel Coron, Marc Barthet, and Geoffroy Vanbiervliet
- Subjects
Adult ,Natural Orifice Endoscopic Surgery ,Adolescent ,Motor Disorders ,Gastroenterology ,Middle Aged ,Esophageal Sphincter, Lower ,Esophageal Achalasia ,Treatment Outcome ,Humans ,Female ,Esophageal Motility Disorders ,Aged ,Retrospective Studies ,Myotomy - Abstract
No recommendation regarding antibiotic prophylaxis and preparation modalities are available for patients with esophageal motor disorders who benefit from Per-Oral Endoscopic Myotomy (POEM). The aim of our study was to evaluate their impact on the POEM's safety.This study was a comparative and multicentric retrospective analysis of a database prospectively collected. Patients over 18 years old with esophageal motor disorders confirmed by prior manometry, who underwent POEM were included. The primary endpoint was the occurrence of adverse events, as classified by Cotton, based on whether or not antibiotic prophylaxis was administered.A total of 226 patients (median age 52.9 ± 19.12 years [18-105], 116 women [51.3%]) were included. The indication for POEM was mainly type 2 achalasia (The antibiotic prophylaxis during POEM does not prevent adverse events, had no impact on their severity and the efficacy of the procedure. A liquid diet before the procedure should be systematically proposed.
- Published
- 2022
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