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1. The association between overweight/obesity and double diabetes in adults with type 1 diabetes; a cross-sectional study

Author: Nathan WP Cantley, Kathryn Lonnen, Ioannis Kyrou, Abd A Tahrani, and Hassan Kahal
Subjects: Type 1 Diabetes Mellitus, Obesity, Overweight, Double diabetes, Insulin resistance, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: Abstract Background Double Diabetes (DD), type 1 diabetes (T1DM) + insulin resistance (IR), is associated with increased risk of micro/macro-vascular complications and mortality. Obesity can contribute to the development of DD. This study explored the prevalence of overweight/obesity and their association with DD in adults with T1DM. Methods Cross-sectional study of consecutive adults with T1DM attending diabetes clinics in a secondary care hospital (January-November 2019). Estimated glucose disposal rate (eGDR) was used as a marker of IR, and an eGDR
Published: 2021
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2. Medication following bariatric surgery for type 2 diabetes mellitus (BY-PLUS) study: rationale and design of a randomised controlled study

Author: Alexander Dimitri Miras, Carel le Roux, Alexis Sudlow, Ricardo Vitor Cohen, Hassan Kahal, Dimitri J Pournaras, Jill Townley, and Helen Heneghan
Subjects: Medicine
Abstract: Introduction Bariatric surgery is an effective method of controlling glycaemia in patients with type 2 diabetes mellitus (T2DM) and obesity. Long-term studies suggest that although glycaemic control remains good, only 20%–40% of patients will maintain remission according to the American Diabetes Association criteria.Purpose This trial aims to examine the safety and efficacy of combining Roux-en-Y gastric bypass or sleeve gastrectomy with goal-directed medical therapy to improve long-term glycaemic control of T2DM.Methods and analysis This prospective, open-label multicentre randomised controlled trial (RCT) will recruit 150 patients with obesity and T2DM from tertiary care obesity centres. Patients will be randomised 1:1 to receive either bariatric surgery and standard medical care or bariatric surgery and intensive goal-directed medical therapy, titrated to specific targets for glycated haemoglobin (HbA1c), blood pressure (BP) and low-density lipoproteins (LDL) cholesterol. The primary endpoints are the proportion of patients in each arm with an HbA1c
Published: 2022
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3. Amyloid-related protein changes associated with dementia differ according to severity of hypoglycemia

Author: Stephen L Atkin, Alexandra E Butler, Abu Saleh Md Moin, Ahmed Al-Qaissi, Hassan Kahal, and Nitya Kumar
Subjects: Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: Introduction Hypoglycemia in type 2 diabetes (T2D) may increase risk for Alzheimer’s disease (AD), but no data on changes in AD-related proteins with differing degrees of hypoglycemia exist. We hypothesized that milder prolonged hypoglycemia would cause greater AD-related protein changes versus severe transient hypoglycemia.Research design and methods Two prospective case-control induced hypoglycemia studies were compared: study 1, hypoglycemic clamp to 2.8 mmol/L (50 mg/dL) for 1 hour in 17 subjects (T2D (n=10), controls (n=7)); study 2, hypoglycemic clamp to 2.0 mmol/L (36 mg/dL) undertaken transiently and reversed in 46 subjects (T2D (n=23), controls (n=23)). Blood sampling at baseline, hypoglycemia and 24-hour post-hypoglycemia, with proteomic analysis of amyloid-related proteins performed.Results In control subjects, the percentage change from baseline to hypoglycemia differed between study 1 and study 2 for 5 of 11 proteins in the AD-related panel: serum amyloid A1 (SAA1) (p=0.009), pappalysin (PAPPA) (p=0.002), apolipoprotein E2 (p=0.02), apolipoprotein E3 (p=0.03) and apolipoprotein E4 (p=0.02). In controls, the percentage change from baseline to 24 hours differed between studies for two proteins: SAA1 (p=0.003) and PAPPA (p=0.004); however, after Bonferroni correction only SAA1 and PAPPA remain significant. In T2D, there were no differential protein changes between the studies.Conclusions The differential changes in AD-related proteins were seen only in control subjects in response to iatrogenic induction of hypoglycemic insults of differing length and severity and may reflect a protective response that was absent in subjects with T2D. Milder prolonged hypoglycemia caused greater AD-related protein changes than severe acute hypoglycemia in control subjects.Trial registration numbers NCT02205996, NCT03102801.
Published: 2021
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4. The relationship between obstructive sleep apnoea and quality of life in women with polycystic ovary syndrome: a cross-sectional study

Author: Hassan Kahal, Abd A. Tahrani, Ioannis Kyrou, Georgios K. Dimitriadis, Peter K. Kimani, Thomas M. Barber, Matthew Nicholls, Asad Ali, Martin O. Weickert, and Harpal S. Randeva
Subjects: Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: Background: Obstructive sleep apnoea (OSA) and polycystic ovary syndrome (PCOS) are associated with significant comorbidities and commonly coexist. The primary aim of this study was to examine the relationship between OSA and quality of life (QoL) in women with PCOS. Methods: We conducted an observational cross-sectional study. PCOS was diagnosed according to the Rotterdam criteria. Women with increased risk of OSA, based on the Berlin questionnaire or the Epworth Sleepiness Scale (ESS), had home-based polysomnography performed (ALICE PDx). Participants were divided into two groups: (a) PCOS only: women with normal ESS and low-risk Berlin questionnaire (no sleep studies performed), or women with normal sleep studies [oxygen desaturation index (ODI)
Published: 2020
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5. Heat Shock-Related Protein Responses and Inflammatory Protein Changes Are Associated with Mild Prolonged Hypoglycemia

Author: Abu Saleh Md Moin, Manjula Nandakumar, Hassan Kahal, Thozhukat Sathyapalan, Stephen L. Atkin, and Alexandra E. Butler
Subjects: type 2 diabetes, hypoglycemia, heat shock proteins, oxidative stress, inflammatory proteins, Cytology, QH573-671
Abstract: Mild hypoglycemia is common in clinical practice. Severe hypoglycemia results in heat shock protein and associate co-chaperone changes. Whether mild prolonged hypoglycemia elicits a similar response with inflammatory and oxidative-stress responses compared with a severe hypoglycemic event is unclear; therefore, this pilot exploratory study was undertaken. We performed a case–control induced hypoglycemia clamp study, maintaining blood glucose at 2.8 mmol/L (50 mg/dL) for 1 h in 17 subjects (T2D (n = 10); controls (n = 7)). Blood sampling was performed at baseline, hypoglycemia, and 24 h; slow off-rate modified aptamer (SOMA)-scan plasma protein analysis of HSP-related proteins, inflammatory stress markers, and oxidative stress markers was performed. In total, 16 HSPs were analyzed. At baseline, TLR4:MD-2 complex was elevated (p = 0.01), whilst HSPA8 was lower (p < 0.05) in T2D. At hypoglycemia, UBE2N, STIP1, and UBE2L3 increased (all p < 0.05), whilst TLR4:MD-2 and HSPA8 decreased (p < 0.05) in T2D versus baseline. In follow-up after hypoglycemia, HSPs normalized to baseline by 24 h, except UBE2L3 (p < 0.05), which was decreased in controls versus baseline. Correlation of altered inflammatory markers with HSPs revealed the following: at baseline, TLR4:MD-2 correlated with CXCL10 (p < 0.01) and SIGLEC1 (p < 0.05) in controls; HSPA8 negatively correlated with IL5 (p < 0.05) in T2D. A negative correlation between urinary isoprostane 8-iso PGF2α, a marker of oxidative stress, and HSPA1A was seen at 24 h in T2D only (p < 0.05). In conclusion, the HSP changes seen for mild prolonged hypoglycemia were similar to those previously reported for a severe event. However, mild prolonged hypoglycemia appeared to elicit an increased inflammatory response that was associated with heat shock and related proteins.
Published: 2021
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6. Pharmacological Treatment of Obesity in Patients with Polycystic Ovary Syndrome

Author: Hassan Kahal, Stephen L. Atkin, and Thozhukat Sathyapalan
Subjects: Internal medicine, RC31-1245
Abstract: Polycystic ovary syndrome (PCOS) is a common disorder affecting women of reproductive age and it is associated with increased cardiovascular risk. Obesity plays an important role in the pathogenesis of PCOS, and the majority of patients with PCOS are obese. Over the last 20 years, the prevalence of obesity has dramatically increased, with probable associated increase in PCOS. Weight reduction plays an integral part in the management of women with PCOS. In this paper, current available weight reduction therapies in the management of PCOS are discussed.
Published: 2011
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7. Medication following bariatric surgery for type 2 diabetes mellitus (BY-PLUS) study: rationale and design of a randomised controlled study

Author: Alexis Sudlow, Alexander Dimitri Miras, Ricardo Vitor Cohen, Hassan Kahal, Jill Townley, Helen Heneghan, Carel Le Roux, and Dimitri J Pournaras
Subjects: Glycated Hemoglobin, Treatment Outcome, Diabetes Mellitus, Type 2, Gastric Bypass, Bariatric Surgery, Humans, General Medicine, Obesity, Obesity, Morbid
Abstract: IntroductionBariatric surgery is an effective method of controlling glycaemia in patients with type 2 diabetes mellitus (T2DM) and obesity. Long-term studies suggest that although glycaemic control remains good, only 20%–40% of patients will maintain remission according to the American Diabetes Association criteria.PurposeThis trial aims to examine the safety and efficacy of combining Roux-en-Y gastric bypass or sleeve gastrectomy with goal-directed medical therapy to improve long-term glycaemic control of T2DM.Methods and analysisThis prospective, open-label multicentre randomised controlled trial (RCT) will recruit 150 patients with obesity and T2DM from tertiary care obesity centres. Patients will be randomised 1:1 to receive either bariatric surgery and standard medical care or bariatric surgery and intensive goal-directed medical therapy, titrated to specific targets for glycated haemoglobin (HbA1c), blood pressure (BP) and low-density lipoproteins (LDL) cholesterol. The primary endpoints are the proportion of patients in each arm with an HbA1cEthics and disseminationThe local institutional review board approved this study. This study represents the first RCT to examine the safety and efficacy of combining bariatric surgery with intensive medical therapy compared with bariatric surgery and usual care for long-term diabetes control.Trial registration numberNCT04432025.
Published: 2022

8. 237-OR: Platelet-Derived Protein Responses Differ According to Severity of Hypoglycemia

Author: ABU MOIN, HASSAN KAHAL, AHMED AL-QAISSI, THOZHUKAT SATHYAPALAN, STEPHEN ATKIN, and ALEXANDRA E. BUTLER
Subjects: Endocrinology, Diabetes and Metabolism, Internal Medicine
Abstract: Introduction: Severe hypoglycemia is associated with an increased risk of cardiovascular (CV) death, and platelet responses to hypoglycemia (hypo) have been described. The impact of a transient severe hypo versus prolonged less severe hypo is unclear. Methods: 2 hypo studies were compared; firstly, in 18 subjects (type 2 diabetes (T2D) : 8 controls) blood glucose lowered to 3.5mmoL/L (90mg/dL) for 1-hour; secondly, in 46 subjects (23 T2D: 23 controls) blood glucose lowered to Results: In T2D, from baseline to hypo, differences were seen for 4 PRPs, three showing increased percent change in study-2 (plasminogen activator inhibitor-1 (PAI-1) , platelet glycoprotein VI (PGVI) and Tissue factor) , one showing increased percent change in study-1 (CD40 ligand (CD40LG)) ; at 24-hours in T2D, percent change for CD40LG remained increased, together with von Willebrand factor (vWF) , in study-2. In controls, from baseline to hypo, differences were seen for four PRPs, three showing increased percent change in study-2 (PAI-1, CD40LG and Protein S) , one showing increased percent change in study-1 (vWF) ; at 24-hours in controls, percent change for Protein S remained increased in study-2, whilst percent change for vWF and plasminogen were increased in study-1. Conclusion: Thrombogenic potential was enhanced in T2D versus controls, as evidenced by an increased thrombogenic protein expression profile in both mild and severe hypoglycemia, that showed persistent changes at 24-hours in severe hypo. Disclosure A. Moin: None. H. Kahal: None.
Published: 2022
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9. Contributors

Author: David H. Abbott, Paola Altieri, Panagiotis Anagnostis, Athanasios Antoniou-Tsigkos, Eleni Armeni, Adam H. Balen, Thomas M. Barber, Salvatore Benvenga, Enrico Carmina, Carolina Cecchetti, Nicolás Crisosto, Flavia Di Bari, Evanthia Diamanti-Kandarakis, Simona Dinicola, Héctor F. Escobar-Morreale, Flaminia Fanelli, T.M. Fighera, Gianpiero Forte, Alessandra Gambineri, Carmen Emanuela Georgescu, Neoklis A. Georgopoulos, Dimitrios G. Goulis, Emily P. Greinwald, Hassan Kahal, Eleni Kandaraki, Ioannis Kyrou, Irene Lambrinoudaki, S.B. Lecke, Jon E. Levine, L.B. Marchesan, Georgios K. Markantes, Mariano Mascarenhas, George Mastorakos, Eleni Memi, Paolo Moghetti, Giovanni Monastra, Seda Hanife Oguz, Uberto Pagotto, Kasiani Papadimitriou, Olga Papalou, Konstantina Pastroma, Sofia S. Pereira, Duarte Pignatelli, Valentina Lo Preiato, Harpal S. Randeva, Danilo Ribichini, B.R. Santos, Suleyman Nahit Sendur, P.M. Spritzer, Marco Tilotta, Gina Tsichlia, Vittorio Unfer, Ugur Unluturk, Nikolaos Vrachnis, Martin O. Weickert, and Bulent Okan Yildiz
Published: 2022
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10. Impact of using fasting plasma glucose and <scp> HbA 1c </scp> instead of <scp>OGTT</scp> as a screening tool for gestational diabetes: a retrospective study

Author: Hannah Cooke, Stephen Craig, Hassan Kahal, Fleur Talbot, and Kathryn Lonnen
Subjects: Endocrinology, Diabetes and Metabolism, Internal Medicine
Published: 2023
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11. Liraglutide (Saxenda®) for the treatment of obesity: a commentary on NICE Technology Appraisal 664

Author: Kamrudeen Mohammed, Kathryn Lonnen, Thozhukat Sathyapalan, Christopher Walton, and Hassan Kahal
Subjects: medicine.medical_specialty, Liraglutide, business.industry, Nice, General Medicine, Overweight, medicine.disease, National health service, Obesity, Clinical Practice, Family medicine, medicine, medicine.symptom, business, computer, health care economics and organizations, medicine.drug, computer.programming_language
Abstract: Saxenda, Liraglutide 3.0 mg, is a glucagon-like peptide-1 (GLP-1) analogue that is licensed for the treatment of adults with overweight and obesity. In this commentary we review the NICE technology appraisal (TA664) on the use of Saxenda in the National Health Service (NHS) and its implication in clinical practice.
Published: 2021
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12. Heat Shock-Related Protein Responses and Inflammatory Protein Changes Are Associated with Mild Prolonged Hypoglycemia

Author: Stephen L. Atkin, Manjula Nandakumar, Abu Saleh Md Moin, Hassan Kahal, Alexandra E. Butler, and Thozhukat Sathyapalan
Subjects: Adult, Male, medicine.medical_specialty, Isoprostane, endocrine system diseases, QH301-705.5, Type 2 diabetes, macromolecular substances, Hypoglycemia, Dinoprost, Article, chemistry.chemical_compound, Heat shock protein, Internal medicine, type 2 diabetes, hypoglycemia, heat shock proteins, oxidative stress, inflammatory proteins, Protein Interaction Mapping, medicine, Humans, Biology (General), Heat-Shock Proteins, Inflammation, business.industry, Proteins, nutritional and metabolic diseases, General Medicine, Middle Aged, medicine.disease, Blood proteins, Oxidative Stress, Endocrinology, chemistry, Diabetes Mellitus, Type 2, Shock (circulatory), Case-Control Studies, Ubiquitin-Conjugating Enzymes, Increased inflammatory response, Female, medicine.symptom, business, Biomarkers, Heat-Shock Response, Blood sampling
Abstract: Mild hypoglycemia is common in clinical practice. Severe hypoglycemia results in heat shock protein and associate co-chaperone changes. Whether mild prolonged hypoglycemia elicits a similar response with inflammatory and oxidative-stress responses compared with a severe hypoglycemic event is unclear; therefore, this pilot exploratory study was undertaken. We performed a case–control induced hypoglycemia clamp study, maintaining blood glucose at 2.8 mmol/L (50 mg/dL) for 1 h in 17 subjects (T2D (n = 10); controls (n = 7)). Blood sampling was performed at baseline, hypoglycemia, and 24 h; slow off-rate modified aptamer (SOMA)-scan plasma protein analysis of HSP-related proteins, inflammatory stress markers, and oxidative stress markers was performed. In total, 16 HSPs were analyzed. At baseline, TLR4:MD-2 complex was elevated (p = 0.01), whilst HSPA8 was lower (p < 0.05) in T2D. At hypoglycemia, UBE2N, STIP1, and UBE2L3 increased (all p < 0.05), whilst TLR4:MD-2 and HSPA8 decreased (p < 0.05) in T2D versus baseline. In follow-up after hypoglycemia, HSPs normalized to baseline by 24 h, except UBE2L3 (p < 0.05), which was decreased in controls versus baseline. Correlation of altered inflammatory markers with HSPs revealed the following: at baseline, TLR4:MD-2 correlated with CXCL10 (p < 0.01) and SIGLEC1 (p < 0.05) in controls; HSPA8 negatively correlated with IL5 (p < 0.05) in T2D. A negative correlation between urinary isoprostane 8-iso PGF2α, a marker of oxidative stress, and HSPA1A was seen at 24 h in T2D only (p < 0.05). In conclusion, the HSP changes seen for mild prolonged hypoglycemia were similar to those previously reported for a severe event. However, mild prolonged hypoglycemia appeared to elicit an increased inflammatory response that was associated with heat shock and related proteins.
Published: 2021
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13. Ectopic Cushing’s syndrome: challenging the stereotype

Author: Elizabeth Cheyne, Fleur Talbot, Georgina Wordsworth, Fong Chau, Vernon Parfitt, Danijela Tatovic, Kathryn Lonnen, Georgina Russell, and Hassan Kahal
Subjects: S syndrome, Stereotype (UML), Psychology, Clinical psychology
Published: 2021
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14. Amyloid-related protein changes associated with dementia differ according to severity of hypoglycemia

Author: Abu Saleh Md Moin, Thozhukat Sathyapalan, Ahmed Al-Qaissi, Stephen L. Atkin, Hassan Kahal, Alexandra E. Butler, and Nitya Kumar
Subjects: Proteomics, medicine.medical_specialty, Apolipoprotein B, endocrine system diseases, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, Hypoglycemia, Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diabetes mellitus, medicine, Humans, Prospective Studies, Pathophysiology/Complications, 030304 developmental biology, 0303 health sciences, biology, business.industry, Serum amyloid A1, nutritional and metabolic diseases, medicine.disease, RC648-665, Endocrinology, Diabetes Mellitus, Type 2, type 2, diabetes mellitus, biology.protein, Dementia, Alzheimer's disease, Alzheimer disease, Apolipoprotein E2, business, Blood sampling
Abstract: IntroductionHypoglycemia in type 2 diabetes (T2D) may increase risk for Alzheimer’s disease (AD), but no data on changes in AD-related proteins with differing degrees of hypoglycemia exist. We hypothesized that milder prolonged hypoglycemia would cause greater AD-related protein changes versus severe transient hypoglycemia.Research design and methodsTwo prospective case-control induced hypoglycemia studies were compared: study 1, hypoglycemic clamp to 2.8 mmol/L (50 mg/dL) for 1 hour in 17 subjects (T2D (n=10), controls (n=7)); study 2, hypoglycemic clamp to 2.0 mmol/L (36 mg/dL) undertaken transiently and reversed in 46 subjects (T2D (n=23), controls (n=23)). Blood sampling at baseline, hypoglycemia and 24-hour post-hypoglycemia, with proteomic analysis of amyloid-related proteins performed.ResultsIn control subjects, the percentage change from baseline to hypoglycemia differed between study 1 and study 2 for 5 of 11 proteins in the AD-related panel: serum amyloid A1 (SAA1) (p=0.009), pappalysin (PAPPA) (p=0.002), apolipoprotein E2 (p=0.02), apolipoprotein E3 (p=0.03) and apolipoprotein E4 (p=0.02). In controls, the percentage change from baseline to 24 hours differed between studies for two proteins: SAA1 (p=0.003) and PAPPA (p=0.004); however, after Bonferroni correction only SAA1 and PAPPA remain significant. In T2D, there were no differential protein changes between the studies.ConclusionsThe differential changes in AD-related proteins were seen only in control subjects in response to iatrogenic induction of hypoglycemic insults of differing length and severity and may reflect a protective response that was absent in subjects with T2D. Milder prolonged hypoglycemia caused greater AD-related protein changes than severe acute hypoglycemia in control subjects.Trial registration numbersNCT02205996, NCT03102801.
Published: 2021

15. Metabolic and proteomic signatures of hypoglycaemia in type 2 diabetes

Author: Anna Halama, Johannes Graumann, Thozhukat Sathyapalan, Jonas Zierer, Stephen L. Atkin, Karsten Suhre, Hassan Kahal, and Aditya M. Bhagwat
Subjects: Adult, Blood Glucose, Male, Proteomics, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Type 2 diabetes, Carbohydrate metabolism, Bile Acids and Salts, Endocrinology, Metabolomics, Internal medicine, Healthy control, Internal Medicine, medicine, Humans, Amino Acids, Linolenate, Inflammation, business.industry, Insulin, Fatty Acids, nutritional and metabolic diseases, Middle Aged, Lipid Metabolism, Pregnenolone sulphate, medicine.disease, Healthy Volunteers, Hypoglycemia, Pathophysiology, Diabetes Mellitus, Type 2, Case-Control Studies, Glucose Clamp Technique, Female, Steroids, business
Abstract: Aims To determine the biochemical changes that underlie hypoglycaemia in a healthy control group and in people with type 2 diabetes (T2D). Materials and methods We report a hypoglycaemic clamp study in seven healthy controls and 10 people with T2D. Blood was withdrawn at four time points: at baseline after an overnight fast; after clamping to euglycaemia at 5 mmol/L; after clamping to hypoglycaemia at 2.8 mmol/L; and 24 hours later, after overnight fast. Deep molecular phenotyping using non-targeted metabolomics and the SomaLogic aptamer-based proteomics platform was performed on collected samples. Results A total of 955 metabolites and 1125 proteins were identified, with significant alterations in >90 molecules. A number of metabolites significantly increased during hypoglycaemia, but only cortisol, adenosine-3',5'-cyclic monophosphate (cyclic AMP), and pregnenolone sulphate, were independent of insulin. By contrast, identified protein changes were triggered by hypoglycaemia rather than insulin. The T2D group had significantly higher levels of fatty acids including 10-nonadecenoate, linolenate and dihomo-linoleate during hypoglycaemia compared with the control group. Molecules contributing to cardiovascular complications such as fatty-acid-binding protein-3 and pregnenolone sulphate were altered in the participants with T2D during hypoglycaemia. Almost all molecules returned to baseline at 24 hours. Conclusions The present study provides a comprehensive description of molecular events that are triggered by insulin-induced hypoglycaemia. We identified deregulated pathways in T2D that may play a role in the pathophysiology of hypoglycaemia-induced cardiovascular complications.
Published: 2019
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16. The effects of treatment with liraglutide on quality of life and depression in young obese women with PCOS and controls

Author: Anne Marie Coady, Stephen L. Atkin, Eric S. Kilpatrick, Alan S. Rigby, and Hassan Kahal
Subjects: Adult, Pediatrics, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Incretins, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Quality of life, Weight Loss, medicine, Humans, Obesity, Depression (differential diagnoses), 030219 obstetrics & reproductive medicine, Depression, Liraglutide, business.industry, Body Weight, Obstetrics and Gynecology, medicine.disease, Polycystic ovary, Cross-Sectional Studies, Case-Control Studies, Quality of Life, Female, business, Polycystic Ovary Syndrome, medicine.drug
Abstract: Polycystic ovary syndrome (PCOS) is associated with reduced quality of life (QoL), though the role of associated obesity is unclear. In this study we examined the effects of six months treatment with liraglutide, 1.8 mg od, on obesity, depression and QoL in young women with PCOS and obesity compared to age- and weight-matched controls. In a cross-sectional study, 36 women were recruited (19 PCOS, 17 controls), age 33.9 ± 6.7 vs. 33.5 ± 7.1 yr, and weight 102.1 ± 17.1 vs. 100.4 ± 15.1 kg, respectively. PCOS was diagnosed according to the Rotterdam criteria. Depression was measured using the Centre for Epidemiologic Studies Depression Scale (CES-D). QoL was measured using the World Health Organization QoL questionnaire (WHOQOL-BREF). At baseline there was no difference in QoL or CES-D scores between the two groups. At six months, weight was reduced by 3.0 ± 4.2 kg, p = .01, in the PCOS group and 3.8 ± 3.4 kg, p = .001, in controls. Psychological health improved in the PCOS group (percentage change 11.3%, p .02). Combining the two groups revealed significant improvement (p .05) in physical (82.6 ± 11.2 vs. 78.9 ± 13.6), psychological (62.4 ± 16.5 vs. 57.5 ± 16.4) and social health (76.6 ± 15.3 vs. 71 ± 16.8) components of the WHOQOL-BREF at six months. Weight loss is associated with an improvement in QoL; and when matched for age and obesity, PCOS was not independently associated with reduced QoL or depression.
Published: 2019
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17. 132-OR: Prolonged Mild Hypoglycemia Elicits Greater Heat Shock Protein Responses than Severe Transient Hypoglycemia

Author: Thozhukat Sathyapalan, Ahmed Al-Qaissi, Hassan Kahal, Alexander S. Atkin, Anu Moin, Stephen Atkin, and Alexandra E. Butler
Subjects: medicine.medical_specialty, endocrine system diseases, business.industry, Endocrinology, Diabetes and Metabolism, nutritional and metabolic diseases, Hypoglycemia, medicine.disease, Endocrinology, Internal medicine, Heat shock protein, Internal Medicine, TLR4, Medicine, DNAJB1, business, Cell damage
Abstract: Introduction: Heat shock proteins (HSPs) protect against protein misfolding, contribute to diabetes-induced complications and are affected by hypoglycemia. Misfolded proteins are degraded by ubiquination through UBE2L3/UBE2N proteins. Methods: Two prospective case-control induced hypoglycemia studies were compared: Study1, hypoglycemic clamp to 2.8mmol/l(50mg/dl) for 1-hour, 17 subjects (T2D(n=10); controls(n=7));Study2, hypoglycemic clamp to 2.0mmol/l(36mg/dl) transiently, 46 subjects (T2D(n=23); controls(n=23)).Blood sampling: baseline, hypoglycemia and 24-hours; Somalogic proteomic analysis of HSPs was undertaken. Results: HSP changes were seen in both studies separately; however, percentage-change baseline to hypoglycemia differed between studies for seven of 19 HSP panel proteins, with notable changes in Study 1: elevated levels in controls at hypoglycemia for TLR4:MD-2(p=0.01) and CD274(p=0.04), and at 24-hours for MAPKAPK5(p=0.047); elevated levels in T2D at hypoglycemia for DNAJB1(p=0.01), STIP1(p=0.01), UBE2L3(p=0.01) and UBE2N(p=0.001) (Figure1). Conclusion: Milder-prolonged hypoglycaemia caused greater HSP changes than severe-acute hypoglycaemia for HSPs protective against protein misfolding and for increasing UBE2L3/UBE2N degradation proteins in T2D, suggesting hypoglycemic duration may cause greater cell damage than severity. Disclosure A. Moin: None. A. S. Atkin: None. H. Kahal: None. A. Al-qaissi: None. T. Sathyapalan: Research Support; Self; Abbott, Eli Lilly and Company, Novo Nordisk. S. Atkin: None. A. E. Butler: None.
Published: 2021
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18. The association between overweight/obesity and double diabetes in adults with type 1 diabetes; a cross-sectional study

Author: Hassan Kahal, Abd A. Tahrani, Nathan W P Cantley, Kathryn Lonnen, and Ioannis Kyrou
Subjects: Adult, Blood Glucose, Male, medicine.medical_specialty, endocrine system diseases, Cross-sectional study, Endocrinology, Diabetes and Metabolism, Population, Overweight, Diseases of the endocrine glands. Clinical endocrinology, Young Adult, Insulin resistance, Weight loss, Diabetes mellitus, Internal medicine, Prevalence, medicine, Humans, Obesity, education, Type 1 diabetes, education.field_of_study, business.industry, Research, nutritional and metabolic diseases, General Medicine, Middle Aged, Type 1 Diabetes Mellitus, Prognosis, RC648-665, medicine.disease, United Kingdom, Double diabetes, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Female, medicine.symptom, business, Biomarkers, Follow-Up Studies
Abstract: Background Double Diabetes (DD), type 1 diabetes (T1DM) + insulin resistance (IR), is associated with increased risk of micro/macro-vascular complications and mortality. Obesity can contribute to the development of DD. This study explored the prevalence of overweight/obesity and their association with DD in adults with T1DM. Methods Cross-sectional study of consecutive adults with T1DM attending diabetes clinics in a secondary care hospital (January-November 2019). Estimated glucose disposal rate (eGDR) was used as a marker of IR, and an eGDR Results One hundred seven adults with T1DM were included; female/male: 51/56; age [median (inter-quartile range): 30.0 (23–51) years]; BMI 25.4 (22.8–30.0) kg/m2. Overweight/obesity prevalence was 57/107 (53.3 %) [overweight: 30/107 (28 %); obesity: 27/107 (25.2 %)]. Compared to those with normal BMI, individuals with T1DM and overweight/obesity had longer diabetes duration; higher total daily insulin dose; and higher DD prevalence: 48/57 (84.2 %) vs. 14/50 (28 %) (p Conclusions Overweight/obesity is very common in adults with T1DM, and is associated with double diabetes. BMI is positively associated with total insulin dose. Double diabetes is associated with adverse cardiovascular risk profile and is also common in lean individuals with T1DM. Further research is needed to examine the impact of overweight/obesity in people with T1DM and whether weight loss in this population can improve diabetes-related outcomes.
Published: 2021
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19. The prevalence of obstructive sleep apnoea in women with polycystic ovary syndrome:a systematic review and meta-analysis

Author: Anna Brown, Peter Wall, Hassan Kahal, Harpal S. Randeva, David G. Parr, Abd A. Tahrani, Olalekan A. Uthman, Ioannis Kyrou, Andrew J. Metcalfe, and Samantha Johnson
Subjects: Adult, medicine.medical_specialty, Adolescent, endocrine system diseases, Polysomnography, Comorbidity, Type 2 diabetes, Epidemiology • Review, OSA, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, PCOS, Odds Ratio, medicine, Humans, Obesity, Risk factor, Sleep Apnea, Obstructive, medicine.diagnostic_test, business.industry, Hyperandrogenism, Insulin resistance, medicine.disease, Polycystic ovary, female genital diseases and pregnancy complications, Cross-Sectional Studies, 030228 respiratory system, Otorhinolaryngology, Meta-analysis, Population study, Female, Neurology (clinical), RG, business, 030217 neurology & neurosurgery, Polycystic Ovary Syndrome, RC
Abstract: Background Obesity is a common risk factor for polycystic ovary syndrome (PCOS) and obstructive sleep apnoea (OSA). Both PCOS and OSA are associated with increased risk of type 2 diabetes and cardiovascular disease. Hence, it is important to determine the burden of OSA in women with PCOS. Methods We searched electronic databases (MEDLINE, Embase, CINAHL, PsycINFO, Scopus, Web of Science, OpenGrey, CENTRAL), conference abstracts, and reference lists of relevant articles, up to January 2019. No restriction for language or publication status. Studies that examined the presence of OSA in women with PCOS using polysomnography and/or level III devices were eligible for inclusion. Results Seventeen studies involving 648 participants were included. Our meta-analysis showed that 35.0% (95% CI 22.2–48.9%) of women with PCOS had OSA. This prevalence was not affected by variation in PCOS definition between studies. Approximately one-tenth of the variation in OSA prevalence was related to differences in study population (higher in adults than adolescents and mixed populations), and around one-tenth was related to sample size (higher in smaller studies). OSA prevalence was markedly higher in obese versus lean women with PCOS, and in women with PCOS compared to controls (odds ratio = 3.83, 95% CI 1.43–10.24, eight studies, 957 participants (349 PCOS and 608 controls)). However, most of the studies were at high risk of selection bias, did not account for important confounders, included predominantly women with class II obesity, and were conducted in one country (USA). Conclusions Future studies need to examine the true prevalence of OSA in a more representative sample of women with PCOS. Nevertheless, our results suggest that the prevalence of OSA in women with PCOS and obesity is high and clinicians should have a high index of suspicion of OSA in these women. Electronic supplementary material The online version of this article (10.1007/s11325-019-01835-1) contains supplementary material, which is available to authorized users.
Published: 2020

20. The prevalence and impact of obesity in adults with type 1 diabetes; a cross-sectional study

Author: Hassan Kahal, Nathan W P Cantley, and Kathryn Lonnen
Subjects: Type 1 diabetes, Cross-sectional study, business.industry, General Chemical Engineering, Environmental health, medicine, medicine.disease, business, Obesity
Published: 2020
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21. Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial

Author: Ruilope, Luis M, Agarwal, Rajiv, Anker, Stefan D, Bakris, George L, Filippatos, Gerasimos, Nowack, Christina, Kolkhof, Peter, Joseph, Amer, Mentenich, Nicole, Pitt, Bertram, Diego, Besada, Alfredo, Wassermann, Julio, Bittar, Alicia, Elbert, Augusto, Vallejos, Gloria, Viñes, Hugo, Sanabria, Federico Pérez Manghi, Alberto, Liberman, Inés, Bartolacci, Diego, Aizenberg, Mariano, Chahin, Laura, Maffei, Elizabeth, Gelersztein, Bernhard, Ludvik, Hans-Robert, Schönherr, Heinz, Drexel, Wolfgang, Preiß, Ursula, Hanusch, Peter, Neudorfer, Friedrich, Prischl, Bernhard, Paulweber, Christoph, Ebenbichler, Rudolf, Prager, Harald, Sourij, Gerit-Holger, Schernthaner, Martin, Clodi, Evelyn, Fliesser-Görzer, Elif, Ekinci, Richard, Macisaac, David, Packham, Hugo, Stephenson, Michael, Suranyi, Gary, Wittert, Katie-Jane, Wynne, Alexia, Pape, Duncan, Topliss, Peter, Colman, Craig, Nelson, James, Vandeleur, David, Colquhoun, Simon, Roger, Peak Mann Mah, Walter, Abhayaratna, Luc VAN Gaal, Pieter, Gillard, Jean-Michel, Hougardy, Marijn, Speeckaert, Koen, Stas, Wendy, Engelen, Francis, Duyck, André, Scheen, Hilde, Vanbelleghem, Peter, Doubel, Svetla, Vasileva, Rosen, Rashkov, Boyan, Nonchev, Theodora, Temelkova-Kurktschieva, Mariana, Yoncheva-Mihaylova, Rangel, Rangelov, Neli, Klyuchkova, Pavel, Stanchev, Zhivko, Tagarev, Radostina, Boshnyashka, Petya, Manova, Zhulieta, Prakova, Mariya, Lucheva, Valentina, Gushterova, Ghassan, Farah, Dimitar, Georgiev, Mariyana, Pichmanova, Dotska, Minkova, Bilyana, Stoyanovska-Elencheva, Maria Eugenia Canziani, Miguel, Hissa, Irene, Noronha, Joao Eduardo Salles, Daniela, Antunes, Freddy, Eliaschewitz, Carlos Eduardo Figueiredo, Rogerio de Paula, Luis, Canani, Maurilo Leite Jr, Bruno, Paolino, Rosangela, Rea, Sergio, Vencio, Claudia, Brito, Raphael, Paschoalin, Roberto Pecoits Filho, Eduardo, Vasconcellos, Nathalia, Paschoalin, Adriana, Forti, Roberto, Botelho, Miguel, Riella, Dalton, Precoma, Maria, Cerqueira, Lilia, Maia, Evandro, Portes, 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Louis van Zyl, Trokis, J, Naresh, Ranjith, Mary, Seeber, Mohamed, Sarvan, Mohammed, Tayob, Brian, Rayner, Larry, Distiller, Heidi, Siebert, Mukesh, Joshi, Paul, Rheeder, Magdalena Madero Rovalo, Gustavo Solache Ortiz, Gustavo Méndez Machado, Rafael Valdez Ortiz, Juan Villagordoa Mesa, Saúl Irizar Santana, Sandro Avila Pardo, Jorge Escobedo de la Peña, Guillermo González Gálvez, Leobardo Sauque Reyna, Miriam Bastidas Adrian, Guillermo Fanghänel Salmón, Ramiro Gutiérrez Ochoa, Luis Nevarez Ruiz, Gabriel Ramos López, Alfredo Chew Wong, Arturo Saldaña Mendoza, Pedro García Hernández, José González González, Melchor Alpizar Salazar, José Lazcano Soto, Amaury, Roman-Miranda, Gregorio, Cortes-Maisonet, Liana, Turcu, Adriana, Dumitrescu, Gabriela, Radulian, Hortensia, Barbonta, Cristina, Mistodie, Georgeta, Vacaru, Alexandrina, Popescu, Adrian, Vlad, Silvia, Paveliu, Nicoleta, Mindrescu, Adrian, Albota, Ella, Pintilei, Lavinia, Pop, Gabriela, Negrisanu, Doina, Catrinoiu, Cornelia, Bala, Amorin, Popa, Iosif, Szilagyi, Ciprian, Constantin, Elena, Caceaune, Adriana, Onaca, Li Yuan Lee, Nor Azizah Aziz, Wan Mohd Izani Wan Mohamed, Wan Hasnul Halimi Bin Wan Hasan, Jeyakantha, Ratnasingam, Nik Nur Fatnoon Nik Ahmad, Rizmy Najme Khir, Norhaliza Mohd Ali, Masni, Mohamad, Chek Loong Loh, Joe, Eustace, John, Holian, Donal, Reddan, Yvonne, O Meara, Mensud, Hatunic, Zuzana, Ochodnicka, Dalibor, Sosovec, Andrej, Dzupina, Ingrid, Buganova, Jana, Babikova, Denisa, Spodniakova, Ruilope, L, Agarwal, R, Anker, S, Bakris, G, Filippatos, G, Nowack, C, Kolkhof, P, Joseph, A, Mentenich, N, Pitt, B, Trevisan, R, Pathology/molecular and cellular medicine, Diabetes Pathology & Therapy, and Diabetes Clinic
Subjects: Male, Endocrinology, Diabetes and Metabolism, Enfermedad cardiovascular, 030232 urology & nephrology, BAY 94-8862, Type 2 diabetes, 030204 cardiovascular system & hematology, Diabete, Kidney, Aparato circulatorio, Azúcar, chemistry.chemical_compound, Mineralocorticoid Receptor Antagonists/therapeutic use, 0302 clinical medicine, Medicine and Health Sciences, Diabetic Nephropathies, Myocardial infarction, Renal Insufficiency, Chronic, Aldosterone, Outcome, Mineralocorticoid Receptor Antagonists, RISK, COMPLICATIONS, Diabetes, Middle Aged, SPIRONOLACTONE, CHRONIC HEART-FAILURE, Treatment Outcome, Mineralocorticoid, Nephrology, Cardiovascular Diseases, Research Design, Disease Progression, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, Type 2, Glomerular Filtration Rate, medicine.medical_specialty, Finerenone, Naphthyridines/therapeutic use, Renal function, Outcomes, 03 medical and health sciences, Clinical, Double-Blind Method, Diabetes mellitus, Internal medicine, medicine, Diabetes Mellitus, Humans, Naphthyridines, Renal Insufficiency, Chronic, ANTAGONIST, Sistema cardiovascular, Aged, Patient-Oriented, Translational Research: Research Article, Diabetic Nephropathies/complications, Renal Insufficiency, Chronic/drug therapy, RECEPTOR, Aldosterone, Clinical, Diabetes, Kidney, Mineralocorticoid, Outcomes, business.industry, Cardiovascular Diseases/epidemiology, Diabetes Mellitus, Type 2/complications, MILD, WORSENING RENAL-FUNCTION, EFFICACY, medicine.disease, chemistry, Diabetes Mellitus, Type 2, Spironolactone, Albuminuria, business, Kidney disease, Follow-Up Studies
Abstract: Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m2 and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
Published: 2019
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22. Pneumomediastinum as a complication of MDMA (3,4-methylenedioxymetamfetamine, Ecstasy) ingestion

Author: Suleiman Ezoubi, William Stephen Waring, and Hassan Kahal
Subjects: Male, Pediatrics, medicine.medical_specialty, Recreational Drug, N-Methyl-3,4-methylenedioxyamphetamine, Amphetamine-Related Disorders, Ecstasy, Critical Care and Intensive Care Medicine, Risk Assessment, Severity of Illness Index, Young Adult, mental disorders, Severity of illness, Internal Medicine, medicine, Humans, Pneumomediastinum, Young adult, Mediastinal Emphysema, business.industry, Gastrointestinal pathology, MDMA, General Medicine, medicine.disease, Treatment Outcome, Emergency Medicine, Tomography, X-Ray Computed, business, Complication, Follow-Up Studies, medicine.drug
Abstract: MDMA (3,4-methylenedioxymethamfetamine, Ecstasy) is a widely used recreational drug. We present a case of pneumomediastinum as a complication of MDMA use in a 21-year-old man with no previous history of lung or gastrointestinal pathology. We have performed a literature review, and summarised the symptoms, signs, and prognosis for this under-recognised complication of a commonly used recreational drug. We recommend enquiring about illicit drug use in any patient presenting with spontaneous pneumomediastinum.
Published: 2016
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23. Platelet function following induced hypoglycaemia in type 2 diabetes

Author: Ahmed Aburima, Benjamin E. J. Spurgeon, Katie S. Wraith, Stephen L. Atkin, Alan S. Rigby, Hassan Kahal, Eric S. Kilpatrick, Thozhukat Sathyapalan, and Khalid M. Naseem
Subjects: Adult, Blood Glucose, Blood Platelets, Male, medicine.medical_specialty, Platelet Function Tests, endocrine system diseases, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Prostacyclin, Type 2 diabetes, 030204 cardiovascular system & hematology, Flow cytometry, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Internal Medicine, medicine, Humans, Platelet, Platelet activation, Whole blood, medicine.diagnostic_test, business.industry, Fibrinogen binding, nutritional and metabolic diseases, General Medicine, Middle Aged, medicine.disease, Platelet Activation, Hypoglycemia, Clamp, Diabetes Mellitus, Type 2, Case-Control Studies, Female, business, medicine.drug
Abstract: Aim: Strict glycaemic control has been associated with an increased mortality rate in subjects with type 2 diabetes (T2DM). Here we examined platelet function immediately and 24 hours following induced hypoglycaemia in people with type 2 diabetes compared to healthy age-matched controls. Methods: Hyperinsulinaemic clamps reduced blood glucose to 2.8 mmol/L (50 mg/dl) for 1 hour. Sampling at baseline; euglycaemia 5 mmol/L (90 mg/dl); hypoglycaemia; and at 24 post clamp were undertaken. Platelet function was measured by whole blood flow cytometry. Results: 10 subjects with T2DM and 8 controls were recruited. Platelets from people with T2DM showed reduced sensitivity to prostacyclin (PGI2, 1 nM) following hypoglycaemia. The ability of PGI2 to inhibit platelet activation was significantly impaired at 24 hours compared to baseline in the T2DM group. Here, inhibition of fibrinogen binding was 29.5% (10.3–43.8) compared to 50.8% (36.8–61.1), (P < 0.05), while inhibition of P-selectin expression was 32% (16.1–47.6) vs. 54.4% (42.5–67.5) (P < 0.05). No significant changes in platelet function were noted in controls. Conclusion: Induced hypoglycaemia in T2DM enhances platelet hyperactivity through impaired sensitivity to prostacyclin at 24 hours.
Published: 2018

24. Effective Implementation of Peri-operative Local Guidelines for Metabolic Surgery in Patients with Diabetes Mellitus in a Tier 4 Setting Demonstrate Improved Work Efficiency and Resource Allocation

Author: Wendy Goodwin, Jenny Abraham, Neha Shah, F T Lam, Vinod Menon, Hassan Kahal, and Thomas M. Barber
Subjects: Adult, Blood Glucose, Male, medicine.medical_specialty, endocrine system diseases, Referral, Endocrinology, Diabetes and Metabolism, Bariatric Surgery, 030209 endocrinology & metabolism, Work efficiency, Pilot Projects, Perioperative Care, Resource Allocation, Tertiary Care Centers, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Medicine, Humans, In patient, 030212 general & internal medicine, Work Performance, Glycated Hemoglobin, Nutrition and Dietetics, business.industry, Metabolic surgery, Health Plan Implementation, Type 2 Diabetes Mellitus, Perioperative, Middle Aged, medicine.disease, United Kingdom, Obesity, Morbid, Diabetes Mellitus, Type 2, Emergency medicine, Resource allocation, Surgery, Female, Guideline Adherence, business, RC, Program Evaluation
Abstract: Background\ud \ud Dynamic changes in glycaemia predominate peri-operatively in patients with type 2 diabetes mellitus (T2DM) undergoing metabolic surgery. There is a lack of consensus and clear guidance on effective glycaemic management of such patients. The aim of this study was to design, pilot, and implement a proforma to improve consistency of glycaemic management and clarity of communication with healthcare professionals following metabolic surgery in patients with T2DM, thereby reducing unnecessary diabetes specialist nurse (DSN) referrals.\ud \ud Methods\ud \ud A proforma was designed and piloted for 12 months to guide healthcare professionals on managing glycaemic therapies for T2DM patients undergoing metabolic surgery. Glycaemic control (HbA1c) and glycaemic therapies were reviewed 3 weeks pre-operatively and a proforma was completed accordingly.\ud \ud Results\ud \ud Of the patients with T2DM (n = 34) who underwent metabolic surgery prior to the new proforma being implemented, 71% (n = 24) had a DSN referral. Half of these referrals were deemed unnecessary by the DSNs. Of the patients with T2DM (n = 33) who underwent metabolic surgery following implementation of the proforma, 21% (n = 7) had a DSN referral. Only 10% of these were deemed unnecessary. Despite the reduced DSN input, no diabetes-related complications were reported.\ud \ud Conclusion\ud \ud Implementation of our proforma effectively halved the proportion of patients with T2DM requiring a DSN referral. Additionally, there was a 40% absolute reduction in the proportion of unnecessary DSN referrals. The proforma improved clarity of communication and guidance for healthcare professionals in the glycaemic management of patients. This also facilitated improved work efficiency and resource allocation.
Published: 2018

25. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial

Author: Gerstein, Hertzel C, primary, Colhoun, Helen M, additional, Dagenais, Gilles R, additional, Diaz, Rafael, additional, Lakshmanan, Mark, additional, Pais, Prem, additional, Probstfield, Jeffrey, additional, Riesmeyer, Jeffrey S, additional, Riddle, Matthew C, additional, Rydén, Lars, additional, Xavier, Denis, additional, Atisso, Charles Messan, additional, Dyal, Leanne, additional, Hall, Stephanie, additional, Rao-Melacini, Purnima, additional, Wong, Gloria, additional, Avezum, Alvaro, additional, Basile, Jan, additional, Chung, Namsik, additional, Conget, Ignacio, additional, Cushman, William C, additional, Franek, Edward, additional, Hancu, Nicolae, additional, Hanefeld, Markolf, additional, Holt, Shaun, additional, Jansky, Petr, additional, Keltai, Matyas, additional, Lanas, Fernando, additional, Leiter, Lawrence A, additional, Lopez-Jaramillo, Patricio, additional, Cardona Munoz, Ernesto German, additional, Pirags, Valdis, additional, Pogosova, Nana, additional, Raubenheimer, Peter J, additional, Shaw, Jonathan E, additional, Sheu, Wayne H-H, additional, Temelkova-Kurktschiev, Theodora, additional, Abella, Mercedes, additional, Alebuena, Andrea, additional, Almagro, Sandra, additional, Amoroso, Eduardo, additional, Anadon, Paula, additional, Andreu, Elizabeth, additional, Aristimuño, Guillermo, additional, Arzadun, Maria, additional, Barbieri, Maria, additional, Barcudi, Raul, additional, Bartolacci, Ines, additional, Bolobanich, Gabriel, additional, Bordonava, Anselmo, additional, Bustamante Labarta, Miguel, additional, Bustos, Betina, additional, Caccavo, Alberto, additional, Camino, Alejandra, additional, Cantero, Maria, additional, Carignano, Maria, additional, Cartasegna, Luis, additional, Cipullo, Marcela, additional, Commendatore, Víctor, additional, Conosciuto, Victoria, additional, Costamagna, Osvaldo, additional, Crespo, Claudia, additional, Cuello, Jose, additional, Cuneo, Carlos, additional, Cusimano, Sandra, additional, Dean, Sofia, additional, Dituro, Claudio, additional, Dominguez, Andrea, additional, Farah, Miguel, additional, Fernandez, Alberto, additional, Fernandez, Florencia, additional, Ferrari, Adriana, additional, Flammia, Patricia, additional, Fuentealba, Jose, additional, Gallardo, Karina Beatriz, additional, Garcia, Celso, additional, Garcia Duran, Ruben, additional, Garrido, Marcelo, additional, Gavicola, Rodolfo, additional, Gerbaudo, Claudio, additional, Gilli, Graciela, additional, Giotto, Ana Paula, additional, Godoy Bolzán, Pedro, additional, Gomez Vilamajo, Oscar, additional, Guerlloy, Fernando, additional, Guridi, Cristian, additional, Gutierrez Garrido, Narcisa, additional, Hasbani, Eduardo, additional, Hermida, Sonia, additional, Hominal, Miguel, additional, Hrabar, Adrian, additional, Ingaramo, Adrián, additional, Izzicupo, Alejandra, additional, Krynski, Mario, additional, Lagrutta, Mariana, additional, Lanchiotti, Paulina, additional, Langhe, Maria, additional, Leonard, Veronica, additional, Llanos, Javier, additional, Lopez Santi, Ricardo, additional, Lowenstein, Jorge, additional, Luquez, Cecilia, additional, Mackinnon, Ignacio, additional, Mana, Melina, additional, Manzur, Sara, additional, Marino, Javier, additional, Martella, Carolina, additional, Martinez, Roger, additional, Matias, Re, additional, Matkovich, Javier, additional, Meritano, Monica, additional, Montaña, Oscar, additional, Mulazzi, María, additional, Ochoa, Juan, additional, Paterlini, Gustavo, additional, Pelagagge, María, additional, Peralta Lopez, Maria Elena, additional, Prado, Aldo, additional, Pruyas, Lorena, additional, Racca, Martín, additional, Ricotti, Carola, additional, Rodriguez, Carolina, additional, Romero Vidomlansky, Mariano, additional, Ronderos, Ricardo, additional, Sadowski, Ana Laura, additional, Sala, Jorgelina, additional, Sánchez, Alejandro, additional, Santoro, Andrea, additional, Schiavi, Lilia, additional, Sein, Mariano, additional, Sernia, Virginia, additional, Serra, Leonardo, additional, Sicer, Maximiliano, additional, Smith, Tomas, additional, Soso, Leonardo, additional, Sposetti, Georgina, additional, Steinacher, Andrea, additional, Stival, Jorge, additional, Tedesco, Jorge, additional, Tonin, Hugo, additional, Tortolo, Mauro, additional, Ulla, Maria, additional, Vallejos, Julio, additional, Vico, Marisa, additional, Virgillito, Luciana, additional, Visco, Virginia, additional, Vogel, Daniel, additional, Waisman, Florencia, additional, Zaidman, César, additional, Zucchiatti, Noemi, additional, Badshah, Imran, additional, Cohen, Neale, additional, Colman, Peter, additional, Colquhoun, David, additional, Davis, Timothy, additional, Fourlanos, Spiros, additional, Fulcher, Greg, additional, Hamlyn, Jane, additional, Haywood, Cilla, additional, Hocking, Samantha, additional, Huchinson, Maeve, additional, Jeffries, William, additional, Kyl, Mervyn, additional, Lo, Clement, additional, Mah, PeakMann, additional, Makepeace, Ashley, additional, Marope, Dolly, additional, Nanayakkar, Natalie, additional, Nankervis, Alison, additional, Palmer, Neil, additional, Palolus, Barbara, additional, Pillai, Satish, additional, Price, Sarah, additional, Proietto, Joseph, additional, Reutens, Anne, additional, Rodrigo, Natassia, additional, Sheikh, Abdul, additional, Smith, Greg, additional, So, Michelle, additional, Soldatos, Georgia, additional, Stuckey, Bronwyn, additional, Sumithran, Priya, additional, Teede, Helena, additional, Vora, Parind, additional, Williams, Lyn, additional, Abib, Eduardo, additional, Adão Poço, Christiani, additional, Alves, Érica Ferreira, additional, Andreatta Bernardi Barea, Janaina, additional, Avezum Oliveira, Livia, additional, Castro, Denise Ludovico da Costa de, additional, Correa da Cruz, Ivan, additional, Costa, Midiã, additional, Cruz, Ivan, additional, Cunha, Sidney, additional, Da Silva, Marco Antonio Vieira, additional, de Carvalho Camara Bona, Renata, additional, de Paula, Bruna, additional, Eliaschewitz, Freddy, additional, Fazolli, Guilherme, additional, Ferreira Filho, Carlos Alberto, additional, Fortes, Jose, additional, França, Cesar, additional, Franco, Denise Reis, additional, Genestreti, Paulo Roberto, additional, Giorgeto, Flavio, additional, Gonçalves, Rodrigo Marques, additional, Grossman, Michele Elka, additional, Henrique Marcelino, Ana Claudia, additional, Hernandes, Mauro, additional, Horta, Ana, additional, Jaeger, Cristiano, additional, Kaneblai, Midia, additional, Kauffman Rutenberg, Cecilia, additional, Kerr Saraiva, Jose Francisco, additional, Lemos, Maria Angelica, additional, Maia, Lilia, additional, Manenti, Euler Roberto, additional, Marques, Mariana, additional, Melissa Valerio, Cynthia, additional, Moreira, Rodrigo, additional, Mothé, Flávia, additional, Mouco, Osana Maria, additional, Moura, Philip, additional, Moura Jorge, José Carlos, additional, Nakashima, Carlos, additional, Nakazone, Marcelo, additional, Napoli, Thiago, additional, Nunes, Cristiane, additional, Nunes Salles, Joao Eduardo, additional, Oliveira, Karla, additional, Oliveira, Marcela, additional, Pantano, Gracielly de Souza, additional, Petri, Fabio, additional, Piazza, Leonardo, additional, Pires, Andreia Carla, additional, Pizzato, Patricia, additional, Prata, Sergio, additional, Precoma, Dalton, additional, Rech, Rafael, additional, Reis, Gilmar, additional, Reis, Heleno, additional, Resende, Elisabete, additional, Ribas Fortes, Jose, additional, Rodovalho, Sylka, additional, Rossi dos Santos, Fabio, additional, Salles, Joao Eduardo, additional, Sampaio, Célia Regina, additional, Santos, Thiago, additional, Santos dos Santos, Vanessa, additional, Silva e Quadros, Tulio, additional, Silveira, Daniel, additional, Siqueira, Katia Nunes, additional, Teireira, M, additional, Uehara, Marcelo, additional, Valerio, C, additional, Vianna, Henrique, additional, Vidotti, Maria Helena, additional, Visconti, Guilherme de Lima, additional, Zanella, Maria Teresa, additional, Andreeva, Viktoriya, additional, Borisov, Radoslav, additional, Botushanov, Nikolay, additional, Dimitrov, Georgi, additional, Dimova, Kameliya, additional, Dragoychev, Tsvetan, additional, Grigorova, Valentina, additional, Gushterova, Valentina, additional, Ivanov, Ivaylo, additional, Kocelova, Tatyana, additional, Kurktschiev, Dimo, additional, Miletieva, Milena, additional, Nenkova-Gugusheva, Neli, additional, Pancheva, Ralitsa, additional, Pavlova, Maria, additional, Raev, Dimitar, additional, Spasova, Vesela, additional, Stoikov, Anastas, additional, Troev, Dimitar, additional, Yanev, Todor, additional, Yoncheva-Mihaylova, Mariana, additional, Abitbol, Alexander, additional, Ajala, Buki, additional, Alguwaihes, Abdullh, additional, Ardilouze, Jean-Luc, additional, Aris-Jilwan, Nahla, additional, Arnaout, Amel, additional, Aronson, Ronnie, additional, Aslam, Nadeem, additional, Babin, Sandra, additional, Bailargeon, Jean-Patrice, additional, Bailey, Allan, additional, Bajaj, Harpreet, additional, Beauchesne, Christian, additional, Beca, Sorin, additional, Belanger, Andre, additional, Bell, Alan, additional, Bellabarba, Diego, additional, Berard, Lori, additional, Berenbaum, Brian, additional, Bergeron, Vincent, additional, Berlingieri, Joseph, additional, Bernier, Frédéric, additional, Bishara, Phoebe, additional, Blank, David, additional, Blumer, Ian, additional, Brault, Suzanne, additional, Breton, Donald, additional, Carpentier, André, additional, Cha, James, additional, Chandra, Prakash, additional, Chiasson, Jean-Louis, additional, Conway, James R, additional, Couture, Ghyslaine, additional, Couture, Nathalie, additional, Dagenais, Gilles, additional, Datta, Dyotirmoy, additional, D'Ignazio, Giuseppe, additional, Dumas, Richard, additional, Fay, Didier, additional, Frechette, Andre, additional, Frenette, Louise, additional, Fung, Daisy, additional, Gagnon, Nathalie, additional, Galter, Meri, additional, Garon, Jean, additional, Gauthier, Jean Sebastien, additional, Geadah, Christian, additional, Gilbert, Jeremy, additional, Girard, Ronald, additional, Goldenberg, Ronald, additional, Grossman, Loren David, additional, Gupta, Nikhil, additional, Halle, Jean-Pierre, additional, Hivert, Marie-France, additional, Houde, Ghislaine, additional, Houlden, Robyn, additional, Hramiak, Irene, additional, Jablonski, Ted, additional, Jain, Akshay Jain, additional, Khandwala, Hasnain, additional, Khosla, Munish, additional, Lachance, C, additional, Laflamme, Emilie, additional, Langlois, Marie-France, additional, Larivee, Luc, additional, Liutkus, Joanne, additional, Lochnan, Heather, additional, Malik, Saleem, additional, McDonald, Charlotte, additional, Mehta, Pravinsagar, additional, Mihailidis, John, additional, Milot, Alain, additional, Narula, Priya, additional, Nault, Patrice, additional, Nayar, Arun, additional, Nisker, William, additional, Ouellet, Gilles, additional, Palardy, Jean, additional, Patel, Minta, additional, Paul, Terri, additional, Pedersen, Sue, additional, Perron, Patrice, additional, Pesant, Marie-Hélène, additional, Poirier, Paul, additional, Poulin, Marie-Claude, additional, Punthakee, Zubin, additional, Rehman, Waheed, additional, Ross, Stuart, additional, Sagar, P, additional, Saliba, Nouhad, additional, Sandler, Sam, additional, Schiffrin, Alicia, additional, Schlosser, Robert, additional, Seth-Sharma, Anila, additional, Sherman, Mark, additional, Sionit, David, additional, Sivakumar, Tharsan, additional, Soto, Juan, additional, St-Amour, Eric, additional, Steen, Oren, additional, Sussman, Jack, additional, Telner, Adam, additional, Tobe, Sheldon, additional, Twum-Barima, David-Yaw, additional, Van Zanten, Audrey, additional, VanRossum, Nicole, additional, Vecchiarelli, Jonathan, additional, Ward, Rick, additional, Wessengel, John, additional, Weisnagel, Stanley, additional, Wilderman, Igor, additional, Woo, Vincent, additional, Yakubovich, Natalia, additional, Yale, Jean-Francois, additional, Yared, Zeina, additional, Acevedo, Monica, additional, Aguirre, Maria Loreto, additional, Aizman, Andres, additional, Barroso, Maria Soledad, additional, Cobos, Leonardo, additional, Danin Vargas, Alfredo, additional, Descalzi, Barbara, additional, Godoy, Gonzalo, additional, Grumberg, Elio, additional, Lahsen, Rodolfo, additional, Larenas, Gladys, additional, Ortiz, Eugenia, additional, Paredes, Javier, additional, Potthoff, Sergio, additional, Retamal, Eva, additional, Rojas, Luis, additional, Salgado, Manuel, additional, Santibanez, Claudio, additional, Solis, Carmen, additional, Stokins, Benjamin, additional, Accini, Jose, additional, Acebedo, Javier, additional, Agudelo Baena, Lina Maria, additional, Alarcon, Soraya, additional, Angel, Juliana, additional, Arcos, Edgar, additional, Aroca Martinez, M, additional, Atuesta, Leonor, additional, Balaguera, Jose, additional, Ballestas, Doris, additional, Barrera, Sandra Isabel, additional, Barrios Reyes, Rosmy, additional, Bayona, Adolfo, additional, Bermudez, Andres, additional, Bernal, Diego Zarate, additional, Blanquicett, Marco, additional, Bravo, Victor, additional, Bueno, Wendy, additional, Burbano Delgado, Alvaro, additional, Cadena, Alberto, additional, Cadena, Andres, additional, Caicedo, Sandra, additional, Celemin, Carlos, additional, Consuegra, Ricardo, additional, Contreras Pimienta, Cristhian, additional, Corredor, Kelly Johenis, additional, Cure, Carlos, additional, De La Hoz Rueda, Lizeth Dayana, additional, Delgado, Erika, additional, Diaz, Sarahy, additional, Diego, Marta, additional, Donado, Anabell, additional, Encinales Sanabria, William, additional, Escobar, Juliana, additional, Escorcia, Gillian, additional, Forero, Leonardo, additional, Fuentes, Laura, additional, Garcia, Maria, additional, Garcia Lozada, Henry, additional, Garcia Ortiz, Luis, additional, Giraldo, Angela, additional, Gomez Gonzalez, Laura, additional, Granada, Javier, additional, Gutierrez, Corina, additional, Henao, Natalia, additional, Hernandez, Edwin, additional, Herrera Uejbe, Olga Maria, additional, Higuera Cobos, Juan Diego, additional, Ibarra Gómez, Jaime, additional, Jaimes, Edwin Hernandez, additional, Jaramillo, Monica, additional, Jaramillo, Nicolas, additional, Jaramillo Gomez, Carlos, additional, Jaramillo Sanchez, Monica, additional, Jarava Durán, Ivonne, additional, Lopez Ceballos, Catalina, additional, Madrid, Claudia, additional, María Amastha, Elias, additional, Mercado, Jennifer, additional, Molina, Dora Ines, additional, Molina Soto, Jessica, additional, Montoya, Carlos, additional, Morales, Alexander, additional, Muñoz, Carolina, additional, Orozco, Luis Alejandro, additional, Osorio, Oscar, additional, Palmera Sanchez, Jorge Mario, additional, Peña, Adwar, additional, Perez, Jose, additional, Perez Agudelo, Juan, additional, Pérez Amador, Germán, additional, Pertuz, Carlos, additional, Posada, Irina, additional, Puerta, Carlos, additional, Quintero, Adalberto, additional, Quiroz, Diana, additional, Rendon, Carmen, additional, Reyes, Alberto, additional, Reyes, Alvaro, additional, Ripoll, Diana, additional, Rivera, Carlos, additional, Rocha, Maria, additional, Rodriguez, Jose F, additional, Rodriguez Villanueva, Kervis Asid, additional, Rodriguez Zabala, Javier Emilio, additional, Rojas, Sindy, additional, Romero, Maria, additional, Rosero, Ricardo, additional, Rosillo Cardenas, Angelica Rocio, additional, Rueda, Lina, additional, Sanchez, Gregorio, additional, Sanchez, Tatiana, additional, Sotomayor Herazo, Arístides, additional, Suarez, Monica, additional, Torres, Mariana, additional, Trujillo, Freddy, additional, Urina, Miguel, additional, Van Strahlen, Lazaro, additional, Velandia, Carlos, additional, Velasquez Guzman, Carolina, additional, Velazquez, Elizabeth, additional, Vidal Prada, Tatiana, additional, Yepez Alvaran, Juan Pablo, additional, Zarate, Diego, additional, Andelova, Jana, additional, Benesova, Radka, additional, Buzova, Barbara, additional, Cech, Vladimir, additional, Chodova, Ida, additional, Choura, Miroslav, additional, Dufka, Antonin, additional, Gamova, Andrea, additional, Gorgol, Jakub, additional, Hala, Tomas, additional, Havlova, Hana, additional, Hlavkova, Dagmar, additional, Horanska, Petra, additional, Ilcisin-Valova, Juliana, additional, Jenickova, Petra, additional, Jerabek, Ondrej, additional, Kantorova, Ilona, additional, Kolomaznikova, Katerina, additional, Kopeckova, Iva, additional, Kopeckova, Miroslava, additional, Linhart, Karel, additional, Linhart, Tomas, additional, Malecha, Jan, additional, Malicherova, Emilia, additional, Neubauerova, Dana, additional, Oznerova, Martina, additional, Partys, Radan, additional, Pederzoliova, Eva, additional, Petrusova, Maria, additional, Prymkova, Vera, additional, Racicka, Eva, additional, Reissova, Ida, additional, Roderova, Eva, additional, Stanek, Libor, additional, Striova, Alena, additional, Svarcova, Dana, additional, Svoboda, Petr, additional, Szeghy Malicharova, Emilia, additional, Urge, Jan, additional, Vesely, Ladislav, additional, Wasserburger, Bedich, additional, Wasserburgerova, Hilde, additional, Zahumensky, Emil, additional, Zamrazil, Vaclav, additional, Alawi, Hasan, additional, Anastasiadis, Ernestos, additional, Axthelm, Elisabeth, additional, Bieler, Tasso, additional, Buhrig, Christina, additional, Degtyareva, Elizaveta, additional, Dellanna, Frank, additional, Derwahl, Karl-Michael, additional, Diessel, Stephan, additional, Dogiami, Barbara, additional, Dorn-Weitzel, Kirsten, additional, Ernst, Monika, additional, Faulmann, Grit, additional, Fetscher, Baerbel, additional, Forst, Thomas, additional, Freyer-Lahres, Gabriele, additional, Funke, Klaus, additional, Ganz, Xenia, additional, Gleixner, Christiane, additional, Hanefeld, Christoph, additional, Heinrichs, Sven, additional, Helleberg, Stephanie, additional, Henkel, Elena, additional, Hetzel, Gerd Ruediger, additional, Hoffmann, Caren, additional, Jacob, Frohmut, additional, Jacob, Stephan, additional, John, Franziska, additional, Jonczyk, Antonius, additional, Kamke, Wolfram, additional, Klein, Christiane, additional, Kleinhardt, Martina, additional, Kleophas, Werner, additional, Kosch, Christine, additional, Kreutzmann, Kristin, additional, Kühn, Achim, additional, Lee-Barkey, Young Hee, additional, Lier, Alexander, additional, Maatouk, Sarah, additional, Minnich, Joachim, additional, Mitry, Michael, additional, Muessig, Ilona, additional, Nicula, Diana, additional, Niemann, Martina, additional, Nothroff, Joerg, additional, Ott, Petra, additional, Pfuetzner, Andreas, additional, Pfützner, Andreas, additional, Pistrosch, Frank, additional, Pohl, Wildgard, additional, Prochazkova, Zdenka, additional, Retkowska, Marlena, additional, Rosin, Heiko, additional, Sachsenheimer, Daniela, additional, Samer, Holger, additional, Sanuri, Mazin, additional, Schaefer, Axel, additional, Schaper, Frank, additional, Schulze, Erik-Delf, additional, Schulze, Marita, additional, Schumann, Martina, additional, Segiet, Thomas, additional, Sowa, Veronika, additional, Stahl, Hans-Detlev, additional, Steinfeldt, Franziska, additional, Teige, Madlen, additional, Trieb, Bjoern, additional, Tschoepe, Diethelm, additional, Uebel, Peter, additional, Warken, Bernd, additional, Weigmann, Ingo, additional, Weyland, Klaus, additional, Wilhelm, Klara, additional, Balo, Timea, additional, Balsay, Miklos, additional, Bende, Ilona, additional, Bezzegh, Katalin, additional, Birkus, Zita, additional, Buday, Barbara, additional, Csomai, Melinda, additional, Deak, Laszlo, additional, Dezso, Eniko, additional, Faludi, Peter, additional, Faluvegi, M, additional, Fazekas, Ilona, additional, Feher, Agota, additional, Fejer, Csaba, additional, Finta, Ervin, additional, Fulcz, Agnes, additional, Gaal, Zsolt, additional, Gurzo, Mihaly, additional, Hati, Krisztina, additional, Herczeg, Gabriella, additional, Jozsef, Ildiko, additional, Juhasz, Marta, additional, Keltai, Katalin, additional, Koranyi, Laszlo, additional, Kulcsar, Eniko, additional, Kun, Krisztina, additional, Laczko, Andrea, additional, Literáti-Nagy, Botond, additional, Mezo, Izabella, additional, Mileder, Margit, additional, Moricz, I, additional, Nagy, Károly, additional, Nagybaczoni, Bela, additional, Nemeth, Csaba, additional, Oze, Agnes, additional, Pauer, Jozsef, additional, Peterfai, Eva, additional, Polocsanyi, Bela, additional, Poor, Ferenc, additional, Reiber, István, additional, Salamon, Csaba, additional, Sebestyen, Julia, additional, Torok, Ildiko, additional, Tuu, Marianna, additional, Varga, Andrea, additional, Vass, Viktor, additional, Ahn, Chul Min, additional, Ahn, Chulwoo, additional, ByungWon, Park, additional, Chang, Hyuk-Jae, additional, Chang, Kiyuk, additional, Choi, Eui-Young, additional, Choi, Han Seok, additional, Chung, Jin-Wook, additional, Hong, Bum- Kee, additional, Hong, Young Joon, additional, Hyon, Min Su, additional, Jeong, Myung Ho, additional, Kang, Shinae, additional, Kim, Byeong-Keuk, additional, Kim, Ji-Hyun, additional, Kim, Ju Han, additional, Kim, Kee-Sik, additional, Kim, Moo Hyun, additional, Kim, Pum-Joon, additional, Kim, Soon-Kil, additional, Kim, Yong-Seok, additional, Kim, Young Kwon, additional, Koh, Yoon Seok, additional, Kwon, Hyuck Moon, additional, Lee, Byoung Kwon, additional, Lee, Byung-Wan, additional, Lee, Jin Bae, additional, Lee, Myoung-Mook, additional, Lim, Young-Mee, additional, Min, Pil Ki, additional, Park, Jong Sung, additional, Park, Jongsuk, additional, Park, Keun Ho, additional, Park, Sungha, additional, Pyun, Wook Bum, additional, Rim, Se Joong, additional, Ryu, Dong-Ryeol, additional, Seo, Hong-Seog, additional, Seung, Ki Bae, additional, Shin, Dong-Ho, additional, Sim, Doo Sun, additional, Yoon, Young Won, additional, Andersone, Ilze, additional, Babicka, Kristine, additional, Balcere, Inga, additional, Barons, Roberts, additional, Capkovska, Inguna, additional, Geldnere, Kristine, additional, Grigane, Inese, additional, Jegere, Baiba, additional, Lagzdina, Ilze, additional, Mora, Lija, additional, Pastare, Sigita, additional, Ritenberga, Rota, additional, Romanova, Janina, additional, Saknite, Inta, additional, Sidlovska, Natalja, additional, Sokolova, Jelena, additional, Steina, Sandra, additional, Strizko, Iveta, additional, Teterovska, Dace, additional, Vizina, Brigita, additional, Barsiene, Lina, additional, Belozariene, Gintare, additional, Daugintyte-Petrusiene, Laura, additional, Drungiliene, Nijole, additional, Garsviene, Nijole, additional, Grigiene, Ala, additional, Grizas, Vytautas, additional, Jociene, Virginija, additional, Kalvaitiene, Dalia, additional, Kaupiene, Jugeta, additional, Kavaliauskiene, Jurate, additional, Kozloviene, Dalia, additional, Lapteva, Ilona, additional, Maneikiene, Birute, additional, Marcinkeviciene, Jolanta, additional, Markauskiene, Vaidilija, additional, Meiluniene, Salomeja, additional, Norkus, Almantas, additional, Norviliene, Rita, additional, Petrenko, Vladimiras, additional, Radzeviciene, Ruta, additional, Sakalyte, Gintare, additional, Urbonas, Gediminas, additional, Urbutiene, Skaiste, additional, Vasiliauskas, Donatas, additional, Velickiene, Dzilda, additional, Aguilar, Carlos, additional, Alcocer, Marco, additional, Avalos-Ramirez, Juan Antonio, additional, Banda-Elizondo, Ramiro, additional, Bricio-Ramirez, Rubria, additional, Cardenas Mejia, Karla, additional, Cavazos, Francisco, additional, Chapa, Jesus, additional, Cienfuegos, Erika, additional, De la Peña, Astrid, additional, de la Peña Topete, Gilberto, additional, De los Rios Ibarra, Manuel Odin, additional, Elias, Daniel, additional, Flores-Moreno, Claudia, additional, Garcia Hernandez, Pedro, additional, Gonzalez, Luis Gerardo, additional, Guerra Moya, Rosa Linda, additional, Guerra-Lopez, Arturo, additional, Hernandez Baylon, Raymundo, additional, Herrera Colorado, Carolina, additional, Herrera-Marmolejo, Marisol, additional, Islas-Palacios, Neri, additional, Lopez, Esteban, additional, Lopez, Fernando, additional, Lopez Alvarado, Agustin, additional, Luna Ceballos, Rosa Isela, additional, Morales Villegas, Enrique, additional, Moreno-Virgen, Gualberto, additional, Parra Perez, Rosa Linda, additional, Pascoe Gonzalez, Sara, additional, Peralta-Cantu, Irving, additional, Previn, Roopa, additional, Ramirez, Rosa, additional, Ramirez, Rubria, additional, Ramos Zavala, Maria Guadalupe, additional, Rodriguez, Monica, additional, Salgado-Sedano, Rocio, additional, Sanchez-Aguilar, Ana Claudia, additional, Santa Rosa Franco, Edith, additional, Sauque-Reyna, Leobardo, additional, Suarez Otero, Rodrigo, additional, Torres, Ivonne, additional, Velarde-Harnandez, Enrique, additional, Villagordoa, Juan, additional, Villeda-Espinoza, Efrain, additional, Vital-Lopez, Jorge, additional, Zavala- Bello, Cristian Jair, additional, Baker, John, additional, Barrington-Ward, Elaine, additional, Brownless, Thomas, additional, Carroll, Richard, additional, Carson, Simon, additional, Choe, Michelle, additional, Corin, Andrew, additional, Corley, Brian, additional, Cutfield, Richard, additional, Dalaman, Neelam, additional, Dixon, Paul, additional, Drury, Paul, additional, Dyson, Keith, additional, Florkowski, Chris, additional, Ford, Monica, additional, Frengley, William, additional, Helm, Colin, additional, Katzen, Colin, additional, Kerr, Jane, additional, Khanolkar, Manish, additional, Kim, David, additional, Koops, Renata, additional, Krebs, Jeremy, additional, Leikis, Robert, additional, Low, Kwan, additional, Luckey, Alison, additional, Luke, Richard, additional, Macaulay, Susan, additional, Marks, Rodney, additional, McNamara, Catherine, additional, Millar-Coote, Dean, additional, Miller, Steven, additional, Mottershead, Naomi, additional, Reid, James, additional, Robertson, Narcisa, additional, Rosen, Ian, additional, Rowe, David, additional, Schmiedel, Ole, additional, Scott, Russell, additional, Sebastian, Jeffrey, additional, Sheahan, Davitt, additional, Stiebel, Victoria, additional, Ternouth, Ian, additional, Tofield, Chris, additional, Venter, Dirk, additional, Williams, Michael, additional, Williams, Miles, additional, Wu, Fiona, additional, Young, Simon, additional, Arciszewska, Malgorzata, additional, Bochenek, Anna, additional, Borkowski, Piotr, additional, Borowy, Przemyslaw, additional, Chrzanowski, Tomasz, additional, Czerwinski, Edward, additional, Dwojak, Marek, additional, Grodzicka, Agnieszka, additional, Janiec, Izabela, additional, Jaruga, Joanna, additional, Jazwinska-Tarnawska, Ewa Krystyna, additional, Jedynasty, Krystyna, additional, Juzwiak-Czapiewska, Danuta, additional, Karczewicz-Janowska, Jadwiga, additional, Konieczny, Jan, additional, Konieczny, Marek, additional, Korol, Marek, additional, Kozina, Maciej, additional, Krzyzagorska, Ewa, additional, Kucharczyk-Petryka, Ewa, additional, Laz, Roman, additional, Majchrzak, Anna, additional, Mrozowska, Zdzislawa, additional, Mularczyk, Michal, additional, Nowacka, Elzbieta, additional, Peczynska, Jadwiga, additional, Petryka, Robert, additional, Pietrzak, Radoslaw, additional, Pisarczyk-Wiza, Dorota, additional, Rozanska, Aleksandra, additional, Ruzga, Zofia, additional, Rzeszotarska, Emilia, additional, Sacha, Malgorzata, additional, Sekulska, Marzenna, additional, Sidorowicz-Bialynicka, Anna, additional, Stasinska, Teresa, additional, Strzelecka-Sosik, Agnieszka, additional, Swierszcz, Teresa, additional, Szymkowiak, Katarzyna Miroslawa, additional, Turowska, Olga, additional, Wisniewska, Krystyna, additional, Wiza, Maciej, additional, Wozniak, Iwona, additional, Zelazowska, Katarzyna, additional, Ziolkowska-Gawron, Bernadetta, additional, Zytkiewicz-Jaruga, Danuta, additional, Albota, Adrian, additional, Alexandru, Carmina, additional, Avram, Rodica, additional, Bala, Cornelia, additional, Barbonta, Diana, additional, Barbu, Roxana, additional, Braicu, Daniela, additional, Calutiu, Nicoleta, additional, Catrinoiu, Doina, additional, Cerghizan, Anca, additional, Ciorba, Alina, additional, Craciun, Anca, additional, Doros, Rodica, additional, Duma, Livia, additional, Dumitrache, Ancuta, additional, Ferariu, Ioana, additional, Ferician Moza, Anca, additional, Ghergan, Alexandrina, additional, Ghise, Gheorghe, additional, Graur, Mariana, additional, Gribovschi, Mihaela, additional, Mihai, Bogdan, additional, Mihalache, Laura, additional, Mihalcea, Madalina, additional, Mindrescu, Nicoleta, additional, Morosanu, Magdalena, additional, Morosoanu, Andrea, additional, Mota, Maria, additional, Moza, Anca, additional, Nafornita, Valerica, additional, Natea, Narcisa, additional, Nicodim, Simona, additional, Nita, Cristina, additional, Onaca, Adriana, additional, Onaca, Mircea, additional, Pop, Cristina, additional, Pop, Lavinia, additional, Popa, Amorin, additional, Popescu, Alexandrina, additional, Pruna, Luchiana, additional, Roman, Gabriela, additional, Rosu, Mihaela, additional, Sima, Alexandra, additional, Sipciu, Doina, additional, Sitterli-Natea, Carmen Narcisa, additional, Szilagyi, Iosif, additional, Tapurica, Minodora, additional, Tase, Adrian, additional, Tutescu, Adriana-Carmen, additional, Vanghelie, Luminita, additional, Verde, Ioana, additional, Vlad, Adrian, additional, Zarnescu, Mihaela, additional, Akhmetov, Roman, additional, Allenova, Irina, additional, Avdeeva, Irina, additional, Baturina, Oksana, additional, Biserova, Irina, additional, Bokovin, Nikolay, additional, Bondar, Irina, additional, Burova, Natalia, additional, Chufeneva, Galina, additional, Chumachek, Elena, additional, Demidova, Marina, additional, Demin, Alexander, additional, Drobysheva, Vera, additional, Egorova, Irina, additional, Esenyan, Lev, additional, Gelig, Ekaterina, additional, Gilyarevsky, Sergey, additional, Golshmid, Maria, additional, Goncharov, Arseniy, additional, Gorbunova, Anastasia, additional, Gordeev, Ivan, additional, Gorelysheva, Vera, additional, Goryunova, Tatiana, additional, Grebenshchikova, Irina, additional, Ilchenko, Roman, additional, Ivannikova, Maria, additional, Karabalieva, Saule, additional, Karpeeva, Juliya, additional, Khaykina, Elena, additional, Kobalava, Zhanna, additional, Kononenko, Irina, additional, Korolik, Oxana, additional, Korshunova, Anna, additional, Kostenko, Victor, additional, Krasnopevtseva, Irina, additional, Krylova, Ludmila, additional, Kulkova, Polina, additional, Kuzmina, Irina, additional, Ledyaeva, Alla, additional, Levashov, Sergey, additional, Lokhovinina, Natalia, additional, Lvov, Vadim, additional, Martirosyan, Narine, additional, Nedogoda, Sergey, additional, Nilk, Rostislav, additional, Osmolovskaya, Yulia, additional, Panov, Alexey, additional, Paramonova, Olga, additional, Pavlova, Ekaterina, additional, Pekareva, Elena, additional, Petunina, Nina, additional, Ponamareva, Svetlana, additional, Reshedko, Galina, additional, Salasyuk, Alla, additional, Sepkhanyan, Malvina, additional, Serebrov, Alexandr, additional, Shabelnikova, Olesya, additional, Skvortsov, Andrey, additional, Smirnova, Olga, additional, Spiridonova, Oxana, additional, Strogova, Svetlana, additional, Taratukhin, Evgeny, additional, Tereschenko, Sergey, additional, Trukhina, Lubov, additional, Tsarkova, Olga, additional, Tsoma, Vera, additional, Tumarov, Farid, additional, Tyan, Natalya, additional, Tyurina, Tatiana, additional, Villevalde, Svetlana, additional, Yankovaya, Elena, additional, Zarutskaya, Ludmila, additional, Zenkova, Elena, additional, Badat, Aysha, additional, Bester, Frederik, additional, Blignaut, Suzanne, additional, Blom, Dirk, additional, Booysen, Susan, additional, Boyd, Warren, additional, Brice, Brigitte, additional, Brown, Susan, additional, Burgess, Lesley, additional, Cawood, Reina, additional, Coetzee, Kathleen, additional, Conradie, Hillet, additional, Cronje, Tanja, additional, de Jong, Douwe, additional, Ellis, Graham, additional, Emanuel, Shaunagh, additional, Engelbrecht, Ingrid, additional, Foulkes, Sharne, additional, Fourie, Done, additional, Gibson, Gilbert, additional, Govender, Thirumani, additional, Hansa, Sumayah, additional, Hemus, Allana Colleen, additional, Hendricks, Firzana, additional, Heradien, Marshall, additional, Holmgren, Chantelle, additional, Hoosain, Zaheer, additional, Horak, Emile, additional, Howard, Johannes, additional, Immink, Ignatius, additional, Janari, E., additional, Jivan, Daksha, additional, Klusmann, Karl, additional, Labuschagne, Weik, additional, Lai, Yen-yu, additional, Latiff, Gulam, additional, Lombaard, J., additional, Lottering, Hanlie, additional, Meeding, Ronel, additional, Middlemost, Shirley, additional, Mitha, Haroon, additional, Mitha, Ismail, additional, Mkhwanazi, Sandile, additional, Moodley, Rajendran, additional, Murray, Almeri, additional, Musungaie, Dany, additional, Osman, Yasmin, additional, Peacey, Kirsten, additional, Pillay-Ramaya, Larisha, additional, Pretorius, Catharina, additional, Prozesky, Hans, additional, Sarvan, Mahomed, additional, Scholtz, E, additional, Sebesteny, Attila, additional, Skinner, Bianca, additional, Skriker, Michael, additional, Smit, M, additional, Stapelberg, Anna-Marie, additional, Swanepoel, Nicolaas, additional, Urbach, Dorothea, additional, van Aswegen, Dina, additional, van Zyl, Francois, additional, Van Zyl, Louis, additional, Venter, Esme, additional, Wadvalla, Shahid, additional, Wing, Jeffrey, additional, Wolmarans, Karen, additional, Abreu, Cristina, additional, Aguilà, Pilar, additional, Aguilera, Eva, additional, Alonso, Nuria, additional, Alvarez, Carmen, additional, Cajas, Priscila, additional, Castro, Jose Carlos, additional, Codinachs, Roger, additional, Contreras, Jose, additional, Coves, Maria Jose, additional, Fajardo, Carmen, additional, Ferrer, Juan Carlos, additional, Font, Neus, additional, Garcia, Mar, additional, Gil, Maria Apolonia, additional, Gomez, Fernando, additional, Gomez, Lluis Alberto, additional, Gonzalbez, Jose, additional, Griera, Jose Luis, additional, Masmiquel, Luís, additional, Mauricio, Didac, additional, Narejos Perez, Silvia, additional, Nicolau, Juana Ana, additional, Noheda Contreras, Olga, additional, Olivan, Josefina, additional, Olivares, Josefina, additional, Ortega, Emilio, additional, Pellitero, Silvia, additional, Pertusa, Salvador, additional, Rius, Ferran, additional, Rodriguez, Irene, additional, Sánchez-Juan, Carlos, additional, Santos, Dolores, additional, Soldevila, Berta, additional, Subias, David, additional, Terns, Manel, additional, Trescoli, Carlos, additional, Vilaplana, Judith, additional, Villanueva, Alicia, additional, Albo, Jaan, additional, Antus, Kjell, additional, Axelsson, Mattias, additional, Bergström, Lisa, additional, Binsell-Gerdin, Emil, additional, Boman, Kurt, additional, Botond, Fabian, additional, Dotevall, Annika, additional, Graipe, Anna, additional, Jarnet, C, additional, Kaminska, Jessica, additional, Kempe, Anders, additional, Korhonen, Michael, additional, Linderfalk, Carina, additional, Liu, Bo, additional, Ljungstroem, Karl, additional, Ljungström, Karl, additional, Malmqvist, Lennart, additional, Mellbin, Linda, additional, Mooe, Thomas, additional, Nicol, Peter, additional, Norrby, Anders, additional, Ohlsson, Ake, additional, Rosengren, Annika, additional, Saaf, Jan, additional, Salmonsson, Staffan, additional, Strandberg, Olof, additional, Svensson, Karl-Axel, additional, Tengmark, Bengt-Olov, additional, Tsatsaris, Georgios, additional, Ulvenstam, Anders, additional, Vasko, Peter, additional, Chang, Chwen-Tzuei, additional, Chang, Hsin-Mei, additional, Chen, Jung-Fu, additional, Chen, To-Pang, additional, Chung, Ming-Min, additional, Fu, Chia-Po, additional, Hsia, Te-Lin, additional, Hua, Shih-Che, additional, Kuo, Ming-Chun, additional, Lee, Chia-ln, additional, Lee, I-Te, additional, Liang, Kae-Woei, additional, Lin, Shih Yi, additional, Lu, Chieh-Hsiang, additional, Ma, Wen-Ya, additional, Pei, Dee, additional, Shen, Feng-Chih, additional, Su, Ching-Chieh, additional, Su, Shuo-Wei, additional, Tai, Tsai-Sung, additional, Tsai, Wan-Ni, additional, Tsai, Yi-Ting, additional, Tung, Shih-Chen, additional, Wang, Jun-Sing, additional, Yu, Hui-I, additional, Al-Qaissi, Ahmed, additional, Arutchelvam, Vijayaraman, additional, Atkin, Stephen, additional, Au, Simon, additional, Aye, Myint Myint, additional, Bain, Stephen, additional, Bejnariu, Cristina, additional, Bell, Patrick, additional, Bhatnagar, Deepak, additional, Bilous, Rudy, additional, Black, Neil, additional, Brennan, Ursula, additional, Brett, Barbara, additional, Bujanova, Jana, additional, Chow, Elaine, additional, Collier, Andrew, additional, Combe, Amanda, additional, Courtney, Christopher, additional, Courtney, Hamish, additional, Crothers, James, additional, Eavis, Patrick, additional, Elliott, Jackie, additional, Febbraro, Salvatore, additional, Finlayson, Jim, additional, Gandhi, Rajiv, additional, Gillings, Sharon, additional, Hamling, Jonathan, additional, Harper, Roy, additional, Harris, Tim, additional, Hassan, Kahal, additional, Heller, Simon, additional, Jane, Alison, additional, Javed, Zeeshan, additional, Johnson, Tim, additional, Jones, Stephen, additional, Kennedy, Adele, additional, Kerr, David, additional, Kilgallon, Brian, additional, Konya, Judith, additional, Lindsay, John, additional, Lomova-Williams, Lina, additional, Looker, Helen, additional, MacFarlane, David, additional, Macrury, Sandra, additional, Malik, Iqbal, additional, McCrimmon, Rory, additional, McKeith, Douglas, additional, McKnight, John, additional, Mishra, Biswa, additional, Mukhtar, Racha, additional, Mulligan, Ciara, additional, O'Kane, Maurice, additional, Olateju, Tolu, additional, Orpen, Ian, additional, Richardson, Tristan, additional, Rooney, Desmond, additional, Ross, Shorsha Bae, additional, Sathyapalan, Thozhukat, additional, Siddaramaiah, Naveen, additional, Sit, Lee Euan, additional, Stephens, Jeffrey, additional, Turtle, Frances, additional, Wakil, Ammar, additional, Walkinshaw, Emma, additional, Ali, Asem, additional, Anderson, Robert, additional, Arakaki, Richard, additional, Aref, Omar, additional, Ariani, Mehrdad Kevin, additional, Arkin, David, additional, Banarer, Salomon, additional, Barchini, George, additional, Bhan, Arti, additional, Branch, Kelley, additional, Brautigam, Donald, additional, Brietzke, Stephen, additional, Brinas, Maridez, additional, Brito, Yudit, additional, Carter, Casey, additional, Casagni, Kimberely, additional, Casula, Sabina, additional, Chakko, Simon, additional, Charatz, Seth, additional, Childress, Dale, additional, Chow, Lisa, additional, Chustecka, Malgorzata, additional, Clarke, Subha, additional, Cohen, Lisa, additional, Collins, Barry, additional, Colon Vega, Gildred, additional, Comulada-Rivera, Angel, additional, Cortes-Maisonet, Gregorio, additional, Davis, Matthew, additional, de Souza, Jose, additional, Desouza, Cyrus, additional, Dinnan, Mary, additional, Duffy-Hidalgo, Bobbi, additional, Dunn, Barbara, additional, Dunn, Julia, additional, Elman, Marshall, additional, Felicetta, James, additional, Finkelstein, Stuart, additional, Fitz-Patrick, David, additional, Florez, Hermes, additional, Forker, Alan, additional, Fowler, Wayne, additional, Fredrickson, Sonja, additional, Freedman, Zachary, additional, Gainey Narron, Brooke, additional, Gainey-Ferree, Kristin, additional, Gardner, Michael, additional, Gastelum, Christian, additional, Giddings, Stephen, additional, Gillespie, Eve, additional, Gimness, Michael Paul, additional, Goldstein, Gary, additional, Gomes, Maria, additional, Gomez, Nelson, additional, Gorman, Timothy, additional, Goswami, Ketan, additional, Graves, Arthur, additional, Hacking, Scott, additional, Hall, Charles, additional, Hanson, Lenita, additional, Harman, Sherman, additional, Heber, David, additional, Henry, Robert, additional, Hiner, Janette, additional, Hirsch, Irl, additional, Hollander, Priscilla, additional, Hooker, Thomas, additional, Horowitz, Barry, additional, Hoste, Laura, additional, Huang, Loli, additional, Huynh, Minh, additional, Hyman, Dan, additional, Idriss, Soha, additional, Iranmanesh, Ali, additional, Karounos, Dennis, additional, Kashyap, Moti, additional, Katz, Lois, additional, Kaye, William, additional, Khaiton, Yevgeniy, additional, Khardori, Romesh, additional, Kitchen, Timothy, additional, Klein, Andrew, additional, Knffem, Wendi, additional, Kosiborod, Mikhail, additional, Kreglinger, Nicola, additional, Kruger, Davida, additional, Kumar, Anubhav, additional, Laboy, Ivan, additional, Larrabee, Patricia, additional, Larrick, Laura, additional, Lawson, Donna, additional, Ledet, Mike, additional, Lenhard, James, additional, Levy, James, additional, Li, George, additional, Li, Zhaoping, additional, Lieb, David, additional, Limcolioc, April, additional, Lions-Patterson, Jane, additional, Lorber, Daniel, additional, Lorch, Daniel, additional, Lorrello, Michael, additional, Lu, Peter, additional, Lucas, Kathryn Jean, additional, Ma, Siu-Ling, additional, MacAdams, Michael, additional, Magee, Michelle, additional, Magno, Alexander, additional, Mahakala, Aparna Reddy, additional, Marks, Jennifer, additional, McCall, Anthony, additional, McClanahan, William, additional, McClary, Carole, additional, Melendez, Lydia, additional, Melish, John, additional, Michaud, Deanna, additional, Miller, Christopher, additional, Miller, Neil, additional, Mora, Pablo, additional, Moten, Marriyam, additional, Mudaliar, Sunder, additional, Myrick, Gregory, additional, Narayan, Puneet, additional, Nassif, Mike, additional, Neri, Karena, additional, Newton, Tabitha, additional, Niblack, Patricia, additional, Nicol, Philip, additional, Nyenwe, Ebenezer, additional, Odugbesan, A. Ola, additional, Okorocha, Yolanda, additional, Ortiz Carrasquillo, Ramón, additional, Osei, Kwame, additional, Palermo, Coromoto, additional, Patel, Hiren, additional, Patel, Krishna, additional, Pau, Cindy, additional, Perley, Michael, additional, Plevin, Sanford, additional, Plummer, Elena, additional, Powell, Richard, additional, Qintar, Mohammed, additional, Rawls, Rex, additional, Reyes-Castano, John, additional, Reynolds, Lillian, additional, Richards, Robert, additional, Rosenstock, Julio, additional, Rowe, Caroline, additional, Saleh, Jahandar, additional, Sam, Sony, additional, Sanchez, Alfredo, additional, Sander, Donald, additional, Sanderson, Bruce, additional, Savin, Virginia, additional, Seaquist, Elizabeth, additional, Shah, Jayendra, additional, Shi, Serena, additional, Shivaswamy, Vijay, additional, Shlotzhauer, Tammi, additional, Shore, David, additional, Skukowski, Bobbie, additional, Soe, Kyaw, additional, Solheim, Vesna, additional, Soufer, Joseph, additional, Steinberg, Helmut, additional, Steinsapir, Jaime, additional, Tarkington, Phillip, additional, Thayer, Debra, additional, Thomson, Stephen, additional, Thrasher, James, additional, Tibaldi, Joseph, additional, Tjaden, Jeff, additional, Tores, Oberto, additional, Trence, Dace, additional, Trikudanathan, Subbulaxmi, additional, Ullal, Jagdeesh, additional, Uwaifo, Gabriel, additional, Vo, Anthony, additional, Vu, Kenny, additional, Walia, Damandeep, additional, Weiland, Karen, additional, Whitehouse, Fred, additional, Wiegmann, Thomas, additional, Wyne, Kathleen, additional, Wynne, Alan, additional, Yuen, Kevin, additional, Zaretzky, Joel, additional, Zebrack, James, additional, Zieve, Franklin, additional, and Zigrang, William, additional
Published: 2019
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26. Dulaglutide and renal outcomes in type 2 diabetes: an exploratory analysis of the REWIND randomised, placebo-controlled trial

Author: Gerstein, Hertzel C, primary, Colhoun, Helen M, additional, Dagenais, Gilles R, additional, Diaz, Rafael, additional, Lakshmanan, Mark, additional, Pais, Prem, additional, Probstfield, Jeffrey, additional, Botros, Fady T, additional, Riddle, Matthew C, additional, Rydén, Lars, additional, Xavier, Denis, additional, Atisso, Charles Messan, additional, Dyal, Leanne, additional, Hall, Stephanie, additional, Rao-Melacini, Purnima, additional, Wong, Gloria, additional, Avezum, Alvaro, additional, Basile, Jan, additional, Chung, Namsik, additional, Conget, Ignacio, additional, Cushman, William C, additional, Franek, Edward, additional, Hancu, Nicolae, additional, Hanefeld, Markolf, additional, Holt, Shaun, additional, Jansky, Petr, additional, Keltai, Matyas, additional, Lanas, Fernando, additional, Leiter, Lawrence A, additional, Lopez-Jaramillo, Patricio, additional, Cardona Munoz, Ernesto German, additional, Pirags, Valdis, additional, Pogosova, Nana, additional, Raubenheimer, Peter J, additional, Shaw, Jonathan E, additional, Sheu, Wayne H-H, additional, Temelkova-Kurktschiev, Theodora, additional, Abella, Mercedes, additional, Alebuena, Andrea, additional, Almagro, Sandra, additional, Amoroso, Eduardo, additional, Anadon, Paula, additional, Andreu, Elizabeth, additional, Aristimuño, Guillermo, additional, Arzadun, Maria, additional, Barbieri, Maria, additional, Barcudi, Raul, additional, Bartolacci, Ines, additional, Bolobanich, Gabriel, additional, Bordonava, Anselmo, additional, Bustamante Labarta, Miguel, additional, Bustos, Betina, additional, Caccavo, Alberto, additional, Camino, Alejandra, additional, Cantero, Maria, additional, Carignano, Maria, additional, Cartasegna, Luis, additional, Cipullo, Marcela, additional, Commendatore, Víctor, additional, Conosciuto, Victoria, additional, Costamagna, Osvaldo, additional, Crespo, Claudia, additional, Cuello, Jose, additional, Cuneo, Carlos, additional, Cusimano, Sandra, additional, Dean, Sofia, additional, Dituro, Claudio, additional, Dominguez, Andrea, additional, Farah, Miguel, additional, Fernandez, Alberto, additional, Fernandez, Florencia, additional, Ferrari, Adriana, additional, Flammia, Patricia, additional, Fuentealba, Jose, additional, Gallardo, Karina Beatriz, additional, Garcia, Celso, additional, Garcia Duran, Ruben, additional, Garrido, Marcelo, additional, Gavicola, Rodolfo, additional, Gerbaudo, Claudio, additional, Gilli, Graciela, additional, Giotto, Ana Paula, additional, Godoy Bolzán, Pedro, additional, Gomez Vilamajo, Oscar, additional, Guerlloy, Fernando, additional, Guridi, Cristian, additional, Gutierrez Garrido, Narcisa, additional, Hasbani, Eduardo, additional, Hermida, Sonia, additional, Hominal, Miguel, additional, Hrabar, Adrian, additional, Ingaramo, Adrián, additional, Izzicupo, Alejandra, additional, Krynski, Mario, additional, Lagrutta, Mariana, additional, Lanchiotti, Paulina, additional, Langhe, Maria, additional, Leonard, Veronica, additional, Llanos, Javier, additional, Lopez Santi, Ricardo, additional, Lowenstein, Jorge, additional, Luquez, Cecilia, additional, Mackinnon, Ignacio, additional, Mana, Melina, additional, Manzur, Sara, additional, Marino, Javier, additional, Martella, Carolina, additional, Martinez, Roger, additional, Matias, Re, additional, Matkovich, Javier, additional, Meritano, Monica, additional, Montaña, Oscar, additional, Mulazzi, María, additional, Ochoa, Juan, additional, Paterlini, Gustavo, additional, Pelagagge, María, additional, Peralta Lopez, Maria Elena, additional, Prado, Aldo, additional, Pruyas, Lorena, additional, Racca, Martín, additional, Ricotti, Carola, additional, Rodriguez, Carolina, additional, Romero Vidomlansky, Mariano, additional, Ronderos, Ricardo, additional, Sadowski, Ana Laura, additional, Sala, Jorgelina, additional, Sánchez, Alejandro, additional, Santoro, Andrea, additional, Schiavi, Lilia, additional, Sein, Mariano, additional, Sernia, Virginia, additional, Serra, Leonardo, additional, Sicer, Maximiliano, additional, Smith, Tomas, additional, Soso, Leonardo, additional, Sposetti, Georgina, additional, Steinacher, Andrea, additional, Stival, Jorge, additional, Tedesco, Jorge, additional, Tonin, Hugo, additional, Tortolo, Mauro, additional, Ulla, Maria, additional, Vallejos, Julio, additional, Vico, Marisa, additional, Virgillito, Luciana, additional, Visco, Virginia, additional, Vogel, Daniel, additional, Waisman, Florencia, additional, Zaidman, César, additional, Zucchiatti, Noemi, additional, Badshah, Imran, additional, Cohen, Neale, additional, Colman, Peter, additional, Colquhoun, David, additional, Davis, Timothy, additional, Fourlanos, Spiros, additional, Fulcher, Greg, additional, Hamlyn, Jane, additional, Haywood, Cilla, additional, Hocking, Samantha, additional, Huchinson, Maeve, additional, Jeffries, William, additional, Kyl, Mervyn, additional, Lo, Clement, additional, Mah, PeakMann, additional, Makepeace, Ashley, additional, Marope, Dolly, additional, Nanayakkar, Natalie, additional, Nankervis, Alison, additional, Palmer, Neil, additional, Palolus, Barbara, additional, Pillai, Satish, additional, Price, Sarah, additional, Proietto, Joseph, additional, Reutens, Anne, additional, Rodrigo, Natassia, additional, Sheikh, Abdul, additional, Smith, Greg, additional, So, Michelle, additional, Soldatos, Georgia, additional, Stuckey, Bronwyn, additional, Sumithran, Priya, additional, Teede, Helena, additional, Vora, Parind, additional, Williams, Lyn, additional, Abib, Eduardo, additional, Adão Poço, Christiani, additional, Alves, Érica Ferreira, additional, Andreatta Bernardi Barea, Janaina, additional, Avezum Oliveira, Livia, additional, Castro, Denise Ludovico da Costa de, additional, Correa da Cruz, Ivan, additional, Costa, Midiã, additional, Cruz, Ivan, additional, Cunha, Sidney, additional, Da Silva, Marco Antonio Vieira, additional, de Carvalho Camara Bona, Renata, additional, de Paula, Bruna, additional, Eliaschewitz, Freddy, additional, Fazolli, Guilherme, additional, Ferreira Filho, Carlos Alberto, additional, Fortes, Jose, additional, França, Cesar, additional, Franco, Denise Reis, additional, Genestreti, Paulo Roberto, additional, Giorgeto, Flavio, additional, Gonçalves, Rodrigo Marques, additional, Grossman, Michele Elka, additional, Henrique Marcelino, Ana Claudia, additional, Hernandes, Mauro, additional, Horta, Ana, additional, Jaeger, Cristiano, additional, Kaneblai, Midia, additional, Kauffman Rutenberg, Cecilia, additional, Kerr Saraiva, Jose Francisco, additional, Lemos, Maria Angelica, additional, Maia, Lilia, additional, Manenti, Euler Roberto, additional, Marques, Mariana, additional, Melissa Valerio, Cynthia, additional, Moreira, Rodrigo, additional, Mothé, Flávia, additional, Mouco, Osana Maria, additional, Moura, Philip, additional, Moura Jorge, José Carlos, additional, Nakashima, Carlos, additional, Nakazone, Marcelo, additional, Napoli, Thiago, additional, Nunes, Cristiane, additional, Nunes Salles, Joao Eduardo, additional, Oliveira, Karla, additional, Oliveira, Marcela, additional, Pantano, Gracielly de Souza, additional, Petri, Fabio, additional, Piazza, Leonardo, additional, Pires, Andreia Carla, additional, Pizzato, Patricia, additional, Prata, Sergio, additional, Precoma, Dalton, additional, Rech, Rafael, additional, Reis, Gilmar, additional, Reis, Heleno, additional, Resende, Elisabete, additional, Ribas Fortes, Jose, additional, Rodovalho, Sylka, additional, Rossi dos Santos, Fabio, additional, Salles, Joao Eduardo, additional, Sampaio, Célia Regina, additional, Santos, Thiago, additional, Santos dos Santos, Vanessa, additional, Silva e Quadros, Tulio, additional, Silveira, Daniel, additional, Siqueira, Katia Nunes, additional, Teireira, M, additional, Uehara, Marcelo, additional, Valerio, C, additional, Vianna, Henrique, additional, Vidotti, Maria Helena, additional, Visconti, Guilherme de Lima, additional, Zanella, Maria Teresa, additional, Andreeva, Viktoriya, additional, Borisov, Radoslav, additional, Botushanov, Nikolay, additional, Dimitrov, Georgi, additional, Dimova, Kameliya, additional, Dragoychev, Tsvetan, additional, Grigorova, Valentina, additional, Gushterova, Valentina, additional, Ivanov, Ivaylo, additional, Kocelova, Tatyana, additional, Kurktschiev, Dimo, additional, Miletieva, Milena, additional, Nenkova-Gugusheva, Neli, additional, Pancheva, Ralitsa, additional, Pavlova, Maria, additional, Raev, Dimitar, additional, Spasova, Vesela, additional, Stoikov, Anastas, additional, Troev, Dimitar, additional, Yanev, Todor, additional, Yoncheva-Mihaylova, Mariana, additional, Abitbol, Alexander, additional, Ajala, Buki, additional, Alguwaihes, Abdullh, additional, Ardilouze, Jean-Luc, additional, Aris-Jilwan, Nahla, additional, Arnaout, Amel, additional, Aronson, Ronnie, additional, Aslam, Nadeem, additional, Babin, Sandra, additional, Bailargeon, Jean-Patrice, additional, Bailey, Allan, additional, Bajaj, Harpreet, additional, Beauchesne, Christian, additional, Beca, Sorin, additional, Belanger, Andre, additional, Bell, Alan, additional, Bellabarba, Diego, additional, Berard, Lori, additional, Berenbaum, Brian, additional, Bergeron, Vincent, additional, Berlingieri, Joseph, additional, Bernier, Frédéric, additional, Bishara, Phoebe, additional, Blank, David, additional, Blumer, Ian, additional, Brault, Suzanne, additional, Breton, Donald, additional, Carpentier, André, additional, Cha, James, additional, Chandra, Prakash, additional, Chiasson, Jean-Louis, additional, Conway, James R, additional, Couture, Ghyslaine, additional, Couture, Nathalie, additional, Dagenais, Gilles, additional, Datta, Dyotirmoy, additional, D'Ignazio, Giuseppe, additional, Dumas, Richard, additional, Fay, Didier, additional, Frechette, Andre, additional, Frenette, Louise, additional, Fung, Daisy, additional, Gagnon, Nathalie, additional, Galter, Meri, additional, Garon, Jean, additional, Gauthier, Jean Sebastien, additional, Geadah, Christian, additional, Gilbert, Jeremy, additional, Girard, Ronald, additional, Goldenberg, Ronald, additional, Grossman, Loren David, additional, Gupta, Nikhil, additional, Halle, Jean-Pierre, additional, Hivert, Marie-France, additional, Houde, Ghislaine, additional, Houlden, Robyn, additional, Hramiak, Irene, additional, Jablonski, Ted, additional, Jain, Akshay Jain, additional, Khandwala, Hasnain, additional, Khosla, Munish, additional, Lachance, C, additional, Laflamme, Emilie, additional, Langlois, Marie-France, additional, Larivee, Luc, additional, Liutkus, Joanne, additional, Lochnan, Heather, additional, Malik, Saleem, additional, McDonald, Charlotte, additional, Mehta, Pravinsagar, additional, Mihailidis, John, additional, Milot, Alain, additional, Narula, Priya, additional, Nault, Patrice, additional, Nayar, Arun, additional, Nisker, William, additional, Ouellet, Gilles, additional, Palardy, Jean, additional, Patel, Minta, additional, Paul, Terri, additional, Pedersen, Sue, additional, Perron, Patrice, additional, Pesant, Marie-Hélène, additional, Poirier, Paul, additional, Poulin, Marie-Claude, additional, Punthakee, Zubin, additional, Rehman, Waheed, additional, Ross, Stuart, additional, Sagar, P, additional, Saliba, Nouhad, additional, Sandler, Sam, additional, Schiffrin, Alicia, additional, Schlosser, Robert, additional, Seth-Sharma, Anila, additional, Sherman, Mark, additional, Sionit, David, additional, Sivakumar, Tharsan, additional, Soto, Juan, additional, St-Amour, Eric, additional, Steen, Oren, additional, Sussman, Jack, additional, Telner, Adam, additional, Tobe, Sheldon, additional, Twum-Barima, David-Yaw, additional, Van Zanten, Audrey, additional, VanRossum, Nicole, additional, Vecchiarelli, Jonathan, additional, Ward, Rick, additional, Wessengel, John, additional, Weisnagel, Stanley, additional, Wilderman, Igor, additional, Woo, Vincent, additional, Yakubovich, Natalia, additional, Yale, Jean-Francois, additional, Yared, Zeina, additional, Acevedo, Monica, additional, Aguirre, Maria Loreto, additional, Aizman, Andres, additional, Barroso, Maria Soledad, additional, Cobos, Leonardo, additional, Danin Vargas, Alfredo, additional, Descalzi, Barbara, additional, Godoy, Gonzalo, additional, Grumberg, Elio, additional, Lahsen, Rodolfo, additional, Larenas, Gladys, additional, Ortiz, Eugenia, additional, Paredes, Javier, additional, Potthoff, Sergio, additional, Retamal, Eva, additional, Rojas, Luis, additional, Salgado, Manuel, additional, Santibanez, Claudio, additional, Solis, Carmen, additional, Stokins, Benjamin, additional, Accini, Jose, additional, Acebedo, Javier, additional, Agudelo Baena, Lina Maria, additional, Alarcon, Soraya, additional, Angel, Juliana, additional, Arcos, Edgar, additional, Aroca Martinez, M, additional, Atuesta, Leonor, additional, Balaguera, Jose, additional, Ballestas, Doris, additional, Barrera, Sandra Isabel, additional, Barrios Reyes, Rosmy, additional, Bayona, Adolfo, additional, Bermudez, Andres, additional, Bernal, Diego Zarate, additional, Blanquicett, Marco, additional, Bravo, Victor, additional, Bueno, Wendy, additional, Burbano Delgado, Alvaro, additional, Cadena, Alberto, additional, Cadena, Andres, additional, Caicedo, Sandra, additional, Celemin, Carlos, additional, Consuegra, Ricardo, additional, Contreras Pimienta, Cristhian, additional, Corredor, Kelly Johenis, additional, Cure, Carlos, additional, De La Hoz Rueda, Lizeth Dayana, additional, Delgado, Erika, additional, Diaz, Sarahy, additional, Diego, Marta, additional, Donado, Anabell, additional, Encinales Sanabria, William, additional, Escobar, Juliana, additional, Escorcia, Gillian, additional, Forero, Leonardo, additional, Fuentes, Laura, additional, Garcia, Maria, additional, Garcia Lozada, Henry, additional, Garcia Ortiz, Luis, additional, Giraldo, Angela, additional, Gomez Gonzalez, Laura, additional, Granada, Javier, additional, Gutierrez, Corina, additional, Henao, Natalia, additional, Hernandez, Edwin, additional, Herrera Uejbe, Olga Maria, additional, Higuera Cobos, Juan Diego, additional, Ibarra Gómez, Jaime, additional, Jaimes, Edwin Hernandez, additional, Jaramillo, Monica, additional, Jaramillo, Nicolas, additional, Jaramillo Gomez, Carlos, additional, Jaramillo Sanchez, Monica, additional, Jarava Durán, Ivonne, additional, Lopez Ceballos, Catalina, additional, Madrid, Claudia, additional, María Amastha, Elias, additional, Mercado, Jennifer, additional, Molina, Dora Ines, additional, Molina Soto, Jessica, additional, Montoya, Carlos, additional, Morales, Alexander, additional, Muñoz, Carolina, additional, Orozco, Luis Alejandro, additional, Osorio, Oscar, additional, Palmera Sanchez, Jorge Mario, additional, Peña, Adwar, additional, Perez, Jose, additional, Perez Agudelo, Juan, additional, Pérez Amador, Germán, additional, Pertuz, Carlos, additional, Posada, Irina, additional, Puerta, Carlos, additional, Quintero, Adalberto, additional, Quiroz, Diana, additional, Rendon, Carmen, additional, Reyes, Alberto, additional, Reyes, Alvaro, additional, Ripoll, Diana, additional, Rivera, Carlos, additional, Rocha, Maria, additional, Rodriguez, Jose F, additional, Rodriguez Villanueva, Kervis Asid, additional, Rodriguez Zabala, Javier Emilio, additional, Rojas, Sindy, additional, Romero, Maria, additional, Rosero, Ricardo, additional, Rosillo Cardenas, Angelica Rocio, additional, Rueda, Lina, additional, Sanchez, Gregorio, additional, Sanchez, Tatiana, additional, Sotomayor Herazo, Arístides, additional, Suarez, Monica, additional, Torres, Mariana, additional, Trujillo, Freddy, additional, Urina, Miguel, additional, Van Strahlen, Lazaro, additional, Velandia, Carlos, additional, Velasquez Guzman, Carolina, additional, Velazquez, Elizabeth, additional, Vidal Prada, Tatiana, additional, Yepez Alvaran, Juan Pablo, additional, Zarate, Diego, additional, Andelova, Jana, additional, Benesova, Radka, additional, Buzova, Barbara, additional, Cech, Vladimir, additional, Chodova, Ida, additional, Choura, Miroslav, additional, Dufka, Antonin, additional, Gamova, Andrea, additional, Gorgol, Jakub, additional, Hala, Tomas, additional, Havlova, Hana, additional, Hlavkova, Dagmar, additional, Horanska, Petra, additional, Ilcisin-Valova, Juliana, additional, Jenickova, Petra, additional, Jerabek, Ondrej, additional, Kantorova, Ilona, additional, Kolomaznikova, Katerina, additional, Kopeckova, Iva, additional, Kopeckova, Miroslava, additional, Linhart, Karel, additional, Linhart, Tomas, additional, Malecha, Jan, additional, Malicherova, Emilia, additional, Neubauerova, Dana, additional, Oznerova, Martina, additional, Partys, Radan, additional, Pederzoliova, Eva, additional, Petrusova, Maria, additional, Prymkova, Vera, additional, Racicka, Eva, additional, Reissova, Ida, additional, Roderova, Eva, additional, Stanek, Libor, additional, Striova, Alena, additional, Svarcova, Dana, additional, Svoboda, Petr, additional, Szeghy Malicharova, Emilia, additional, Urge, Jan, additional, Vesely, Ladislav, additional, Wasserburger, Bedich, additional, Wasserburgerova, Hilde, additional, Zahumensky, Emil, additional, Zamrazil, Vaclav, additional, Alawi, Hasan, additional, Anastasiadis, Ernestos, additional, Axthelm, Elisabeth, additional, Bieler, Tasso, additional, Buhrig, Christina, additional, Degtyareva, Elizaveta, additional, Dellanna, Frank, additional, Derwahl, Karl-Michael, additional, Diessel, Stephan, additional, Dogiami, Barbara, additional, Dorn-Weitzel, Kirsten, additional, Ernst, Monika, additional, Faulmann, Grit, additional, Fetscher, Baerbel, additional, Forst, Thomas, additional, Freyer-Lahres, Gabriele, additional, Funke, Klaus, additional, Ganz, Xenia, additional, Gleixner, Christiane, additional, Hanefeld, Christoph, additional, Heinrichs, Sven, additional, Helleberg, Stephanie, additional, Henkel, Elena, additional, Hetzel, Gerd Ruediger, additional, Hoffmann, Caren, additional, Jacob, Frohmut, additional, Jacob, Stephan, additional, John, Franziska, additional, Jonczyk, Antonius, additional, Kamke, Wolfram, additional, Klein, Christiane, additional, Kleinhardt, Martina, additional, Kleophas, Werner, additional, Kosch, Christine, additional, Kreutzmann, Kristin, additional, Kühn, Achim, additional, Lee-Barkey, Young Hee, additional, Lier, Alexander, additional, Maatouk, Sarah, additional, Minnich, Joachim, additional, Mitry, Michael, additional, Muessig, Ilona, additional, Nicula, Diana, additional, Niemann, Martina, additional, Nothroff, Joerg, additional, Ott, Petra, additional, Pfuetzner, Andreas, additional, Pfützner, Andreas, additional, Pistrosch, Frank, additional, Pohl, Wildgard, additional, Prochazkova, Zdenka, additional, Retkowska, Marlena, additional, Rosin, Heiko, additional, Sachsenheimer, Daniela, additional, Samer, Holger, additional, Sanuri, Mazin, additional, Schaefer, Axel, additional, Schaper, Frank, additional, Schulze, Erik-Delf, additional, Schulze, Marita, additional, Schumann, Martina, additional, Segiet, Thomas, additional, Sowa, Veronika, additional, Stahl, Hans-Detlev, additional, Steinfeldt, Franziska, additional, Teige, Madlen, additional, Trieb, Bjoern, additional, Tschoepe, Diethelm, additional, Uebel, Peter, additional, Warken, Bernd, additional, Weigmann, Ingo, additional, Weyland, Klaus, additional, Wilhelm, Klara, additional, Balo, Timea, additional, Balsay, Miklos, additional, Bende, Ilona, additional, Bezzegh, Katalin, additional, Birkus, Zita, additional, Buday, Barbara, additional, Csomai, Melinda, additional, Deak, Laszlo, additional, Dezso, Eniko, additional, Faludi, Peter, additional, Faluvegi, M, additional, Fazekas, Ilona, additional, Feher, Agota, additional, Fejer, Csaba, additional, Finta, Ervin, additional, Fulcz, Agnes, additional, Gaal, Zsolt, additional, Gurzo, Mihaly, additional, Hati, Krisztina, additional, Herczeg, Gabriella, additional, Jozsef, Ildiko, additional, Juhasz, Marta, additional, Keltai, Katalin, additional, Koranyi, Laszlo, additional, Kulcsar, Eniko, additional, Kun, Krisztina, additional, Laczko, Andrea, additional, Literáti-Nagy, Botond, additional, Mezo, Izabella, additional, Mileder, Margit, additional, Moricz, I, additional, Nagy, Károly, additional, Nagybaczoni, Bela, additional, Nemeth, Csaba, additional, Oze, Agnes, additional, Pauer, Jozsef, additional, Peterfai, Eva, additional, Polocsanyi, Bela, additional, Poor, Ferenc, additional, Reiber, István, additional, Salamon, Csaba, additional, Sebestyen, Julia, additional, Torok, Ildiko, additional, Tuu, Marianna, additional, Varga, Andrea, additional, Vass, Viktor, additional, Ahn, Chul Min, additional, Ahn, Chulwoo, additional, ByungWon, Park, additional, Chang, Hyuk-Jae, additional, Chang, Kiyuk, additional, Choi, Eui-Young, additional, Choi, Han Seok, additional, Chung, Jin-Wook, additional, Hong, Bum- Kee, additional, Hong, Young Joon, additional, Hyon, Min Su, additional, Jeong, Myung Ho, additional, Kang, Shinae, additional, Kim, Byeong-Keuk, additional, Kim, Ji-Hyun, additional, Kim, Ju Han, additional, Kim, Kee-Sik, additional, Kim, Moo Hyun, additional, Kim, Pum-Joon, additional, Kim, Soon-Kil, additional, Kim, Yong-Seok, additional, Kim, Young Kwon, additional, Koh, Yoon Seok, additional, Kwon, Hyuck Moon, additional, Lee, Byoung Kwon, additional, Lee, Byung-Wan, additional, Lee, Jin Bae, additional, Lee, Myoung-Mook, additional, Lim, Young-Mee, additional, Min, Pil Ki, additional, Park, Jong Sung, additional, Park, Jongsuk, additional, Park, Keun Ho, additional, Park, Sungha, additional, Pyun, Wook Bum, additional, Rim, Se Joong, additional, Ryu, Dong-Ryeol, additional, Seo, Hong-Seog, additional, Seung, Ki Bae, additional, Shin, Dong-Ho, additional, Sim, Doo Sun, additional, Yoon, Young Won, additional, Andersone, Ilze, additional, Babicka, Kristine, additional, Balcere, Inga, additional, Barons, Roberts, additional, Capkovska, Inguna, additional, Geldnere, Kristine, additional, Grigane, Inese, additional, Jegere, Baiba, additional, Lagzdina, Ilze, additional, Mora, Lija, additional, Pastare, Sigita, additional, Ritenberga, Rota, additional, Romanova, Janina, additional, Saknite, Inta, additional, Sidlovska, Natalja, additional, Sokolova, Jelena, additional, Steina, Sandra, additional, Strizko, Iveta, additional, Teterovska, Dace, additional, Vizina, Brigita, additional, Barsiene, Lina, additional, Belozariene, Gintare, additional, Daugintyte-Petrusiene, Laura, additional, Drungiliene, Nijole, additional, Garsviene, Nijole, additional, Grigiene, Ala, additional, Grizas, Vytautas, additional, Jociene, Virginija, additional, Kalvaitiene, Dalia, additional, Kaupiene, Jugeta, additional, Kavaliauskiene, Jurate, additional, Kozloviene, Dalia, additional, Lapteva, Ilona, additional, Maneikiene, Birute, additional, Marcinkeviciene, Jolanta, additional, Markauskiene, Vaidilija, additional, Meiluniene, Salomeja, additional, Norkus, Almantas, additional, Norviliene, Rita, additional, Petrenko, Vladimiras, additional, Radzeviciene, Ruta, additional, Sakalyte, Gintare, additional, Urbonas, Gediminas, additional, Urbutiene, Skaiste, additional, Vasiliauskas, Donatas, additional, Velickiene, Dzilda, additional, Aguilar, Carlos, additional, Alcocer, Marco, additional, Avalos-Ramirez, Juan Antonio, additional, Banda-Elizondo, Ramiro, additional, Bricio-Ramirez, Rubria, additional, Cardenas Mejia, Karla, additional, Cavazos, Francisco, additional, Chapa, Jesus, additional, Cienfuegos, Erika, additional, De la Peña, Astrid, additional, de la Peña Topete, Gilberto, additional, De los Rios Ibarra, Manuel Odin, additional, Elias, Daniel, additional, Flores-Moreno, Claudia, additional, Garcia Hernandez, Pedro, additional, Gonzalez, Luis Gerardo, additional, Guerra Moya, Rosa Linda, additional, Guerra-Lopez, Arturo, additional, Hernandez Baylon, Raymundo, additional, Herrera Colorado, Carolina, additional, Herrera-Marmolejo, Marisol, additional, Islas-Palacios, Neri, additional, Lopez, Esteban, additional, Lopez, Fernando, additional, Lopez Alvarado, Agustin, additional, Luna Ceballos, Rosa Isela, additional, Morales Villegas, Enrique, additional, Moreno-Virgen, Gualberto, additional, Parra Perez, Rosa Linda, additional, Pascoe Gonzalez, Sara, additional, Peralta-Cantu, Irving, additional, Previn, Roopa, additional, Ramirez, Rosa, additional, Ramirez, Rubria, additional, Ramos Zavala, Maria Guadalupe, additional, Rodriguez, Monica, additional, Salgado-Sedano, Rocio, additional, Sanchez-Aguilar, Ana Claudia, additional, Santa Rosa Franco, Edith, additional, Sauque-Reyna, Leobardo, additional, Suarez Otero, Rodrigo, additional, Torres, Ivonne, additional, Velarde-Harnandez, Enrique, additional, Villagordoa, Juan, additional, Villeda-Espinoza, Efrain, additional, Vital-Lopez, Jorge, additional, Zavala- Bello, Cristian Jair, additional, Baker, John, additional, Barrington-Ward, Elaine, additional, Brownless, Thomas, additional, Carroll, Richard, additional, Carson, Simon, additional, Choe, Michelle, additional, Corin, Andrew, additional, Corley, Brian, additional, Cutfield, Richard, additional, Dalaman, Neelam, additional, Dixon, Paul, additional, Drury, Paul, additional, Dyson, Keith, additional, Florkowski, Chris, additional, Ford, Monica, additional, Frengley, William, additional, Helm, Colin, additional, Katzen, Colin, additional, Kerr, Jane, additional, Khanolkar, Manish, additional, Kim, David, additional, Koops, Renata, additional, Krebs, Jeremy, additional, Leikis, Robert, additional, Low, Kwan, additional, Luckey, Alison, additional, Luke, Richard, additional, Macaulay, Susan, additional, Marks, Rodney, additional, McNamara, Catherine, additional, Millar-Coote, Dean, additional, Miller, Steven, additional, Mottershead, Naomi, additional, Reid, James, additional, Robertson, Narcisa, additional, Rosen, Ian, additional, Rowe, David, additional, Schmiedel, Ole, additional, Scott, Russell, additional, Sebastian, Jeffrey, additional, Sheahan, Davitt, additional, Stiebel, Victoria, additional, Ternouth, Ian, additional, Tofield, Chris, additional, Venter, Dirk, additional, Williams, Michael, additional, Williams, Miles, additional, Wu, Fiona, additional, Young, Simon, additional, Arciszewska, Malgorzata, additional, Bochenek, Anna, additional, Borkowski, Piotr, additional, Borowy, Przemyslaw, additional, Chrzanowski, Tomasz, additional, Czerwinski, Edward, additional, Dwojak, Marek, additional, Grodzicka, Agnieszka, additional, Janiec, Izabela, additional, Jaruga, Joanna, additional, Jazwinska-Tarnawska, Ewa Krystyna, additional, Jedynasty, Krystyna, additional, Juzwiak-Czapiewska, Danuta, additional, Karczewicz-Janowska, Jadwiga, additional, Konieczny, Jan, additional, Konieczny, Marek, additional, Korol, Marek, additional, Kozina, Maciej, additional, Krzyzagorska, Ewa, additional, Kucharczyk-Petryka, Ewa, additional, Laz, Roman, additional, Majchrzak, Anna, additional, Mrozowska, Zdzislawa, additional, Mularczyk, Michal, additional, Nowacka, Elzbieta, additional, Peczynska, Jadwiga, additional, Petryka, Robert, additional, Pietrzak, Radoslaw, additional, Pisarczyk-Wiza, Dorota, additional, Rozanska, Aleksandra, additional, Ruzga, Zofia, additional, Rzeszotarska, Emilia, additional, Sacha, Malgorzata, additional, Sekulska, Marzenna, additional, Sidorowicz-Bialynicka, Anna, additional, Stasinska, Teresa, additional, Strzelecka-Sosik, Agnieszka, additional, Swierszcz, Teresa, additional, Szymkowiak, Katarzyna Miroslawa, additional, Turowska, Olga, additional, Wisniewska, Krystyna, additional, Wiza, Maciej, additional, Wozniak, Iwona, additional, Zelazowska, Katarzyna, additional, Ziolkowska-Gawron, Bernadetta, additional, Zytkiewicz-Jaruga, Danuta, additional, Albota, Adrian, additional, Alexandru, Carmina, additional, Avram, Rodica, additional, Bala, Cornelia, additional, Barbonta, Diana, additional, Barbu, Roxana, additional, Braicu, Daniela, additional, Calutiu, Nicoleta, additional, Catrinoiu, Doina, additional, Cerghizan, Anca, additional, Ciorba, Alina, additional, Craciun, Anca, additional, Doros, Rodica, additional, Duma, Livia, additional, Dumitrache, Ancuta, additional, Ferariu, Ioana, additional, Ferician Moza, Anca, additional, Ghergan, Alexandrina, additional, Ghise, Gheorghe, additional, Graur, Mariana, additional, Gribovschi, Mihaela, additional, Mihai, Bogdan, additional, Mihalache, Laura, additional, Mihalcea, Madalina, additional, Mindrescu, Nicoleta, additional, Morosanu, Magdalena, additional, Morosoanu, Andrea, additional, Mota, Maria, additional, Moza, Anca, additional, Nafornita, Valerica, additional, Natea, Narcisa, additional, Nicodim, Simona, additional, Nita, Cristina, additional, Onaca, Adriana, additional, Onaca, Mircea, additional, Pop, Cristina, additional, Pop, Lavinia, additional, Popa, Amorin, additional, Popescu, Alexandrina, additional, Pruna, Luchiana, additional, Roman, Gabriela, additional, Rosu, Mihaela, additional, Sima, Alexandra, additional, Sipciu, Doina, additional, Sitterli-Natea, Carmen Narcisa, additional, Szilagyi, Iosif, additional, Tapurica, Minodora, additional, Tase, Adrian, additional, Tutescu, Adriana-Carmen, additional, Vanghelie, Luminita, additional, Verde, Ioana, additional, Vlad, Adrian, additional, Zarnescu, Mihaela, additional, Akhmetov, Roman, additional, Allenova, Irina, additional, Avdeeva, Irina, additional, Baturina, Oksana, additional, Biserova, Irina, additional, Bokovin, Nikolay, additional, Bondar, Irina, additional, Burova, Natalia, additional, Chufeneva, Galina, additional, Chumachek, Elena, additional, Demidova, Marina, additional, Demin, Alexander, additional, Drobysheva, Vera, additional, Egorova, Irina, additional, Esenyan, Lev, additional, Gelig, Ekaterina, additional, Gilyarevsky, Sergey, additional, Golshmid, Maria, additional, Goncharov, Arseniy, additional, Gorbunova, Anastasia, additional, Gordeev, Ivan, additional, Gorelysheva, Vera, additional, Goryunova, Tatiana, additional, Grebenshchikova, Irina, additional, Ilchenko, Roman, additional, Ivannikova, Maria, additional, Karabalieva, Saule, additional, Karpeeva, Juliya, additional, Khaykina, Elena, additional, Kobalava, Zhanna, additional, Kononenko, Irina, additional, Korolik, Oxana, additional, Korshunova, Anna, additional, Kostenko, Victor, additional, Krasnopevtseva, Irina, additional, Krylova, Ludmila, additional, Kulkova, Polina, additional, Kuzmina, Irina, additional, Ledyaeva, Alla, additional, Levashov, Sergey, additional, Lokhovinina, Natalia, additional, Lvov, Vadim, additional, Martirosyan, Narine, additional, Nedogoda, Sergey, additional, Nilk, Rostislav, additional, Osmolovskaya, Yulia, additional, Panov, Alexey, additional, Paramonova, Olga, additional, Pavlova, Ekaterina, additional, Pekareva, Elena, additional, Petunina, Nina, additional, Ponamareva, Svetlana, additional, Reshedko, Galina, additional, Salasyuk, Alla, additional, Sepkhanyan, Malvina, additional, Serebrov, Alexandr, additional, Shabelnikova, Olesya, additional, Skvortsov, Andrey, additional, Smirnova, Olga, additional, Spiridonova, Oxana, additional, Strogova, Svetlana, additional, Taratukhin, Evgeny, additional, Tereschenko, Sergey, additional, Trukhina, Lubov, additional, Tsarkova, Olga, additional, Tsoma, Vera, additional, Tumarov, Farid, additional, Tyan, Natalya, additional, Tyurina, Tatiana, additional, Villevalde, Svetlana, additional, Yankovaya, Elena, additional, Zarutskaya, Ludmila, additional, Zenkova, Elena, additional, Badat, Aysha, additional, Bester, Frederik, additional, Blignaut, Suzanne, additional, Blom, Dirk, additional, Booysen, Susan, additional, Boyd, Warren, additional, Brice, Brigitte, additional, Brown, Susan, additional, Burgess, Lesley, additional, Cawood, Reina, additional, Coetzee, Kathleen, additional, Conradie, Hillet, additional, Cronje, Tanja, additional, de Jong, Douwe, additional, Ellis, Graham, additional, Emanuel, Shaunagh, additional, Engelbrecht, Ingrid, additional, Foulkes, Sharne, additional, Fourie, Done, additional, Gibson, Gilbert, additional, Govender, Thirumani, additional, Hansa, Sumayah, additional, Hemus, Allana Colleen, additional, Hendricks, Firzana, additional, Heradien, Marshall, additional, Holmgren, Chantelle, additional, Hoosain, Zaheer, additional, Horak, Emile, additional, Howard, Johannes, additional, Immink, Ignatius, additional, Janari, E., additional, Jivan, Daksha, additional, Klusmann, Karl, additional, Labuschagne, Weik, additional, Lai, Yen-yu, additional, Latiff, Gulam, additional, Lombaard, J., additional, Lottering, Hanlie, additional, Meeding, Ronel, additional, Middlemost, Shirley, additional, Mitha, Haroon, additional, Mitha, Ismail, additional, Mkhwanazi, Sandile, additional, Moodley, Rajendran, additional, Murray, Almeri, additional, Musungaie, Dany, additional, Osman, Yasmin, additional, Peacey, Kirsten, additional, Pillay-Ramaya, Larisha, additional, Pretorius, Catharina, additional, Prozesky, Hans, additional, Sarvan, Mahomed, additional, Scholtz, E, additional, Sebesteny, Attila, additional, Skinner, Bianca, additional, Skriker, Michael, additional, Smit, M, additional, Stapelberg, Anna-Marie, additional, Swanepoel, Nicolaas, additional, Urbach, Dorothea, additional, van Aswegen, Dina, additional, van Zyl, Francois, additional, Van Zyl, Louis, additional, Venter, Esme, additional, Wadvalla, Shahid, additional, Wing, Jeffrey, additional, Wolmarans, Karen, additional, Abreu, Cristina, additional, Aguilà, Pilar, additional, Aguilera, Eva, additional, Alonso, Nuria, additional, Alvarez, Carmen, additional, Cajas, Priscila, additional, Castro, Jose Carlos, additional, Codinachs, Roger, additional, Contreras, Jose, additional, Coves, Maria Jose, additional, Fajardo, Carmen, additional, Ferrer, Juan Carlos, additional, Font, Neus, additional, Garcia, Mar, additional, Gil, Maria Apolonia, additional, Gomez, Fernando, additional, Gomez, Lluis Alberto, additional, Gonzalbez, Jose, additional, Griera, Jose Luis, additional, Masmiquel, Luís, additional, Mauricio, Didac, additional, Narejos Perez, Silvia, additional, Nicolau, Juana Ana, additional, Noheda Contreras, Olga, additional, Olivan, Josefina, additional, Olivares, Josefina, additional, Ortega, Emilio, additional, Pellitero, Silvia, additional, Pertusa, Salvador, additional, Rius, Ferran, additional, Rodriguez, Irene, additional, Sánchez-Juan, Carlos, additional, Santos, Dolores, additional, Soldevila, Berta, additional, Subias, David, additional, Terns, Manel, additional, Trescoli, Carlos, additional, Vilaplana, Judith, additional, Villanueva, Alicia, additional, Albo, Jaan, additional, Antus, Kjell, additional, Axelsson, Mattias, additional, Bergström, Lisa, additional, Binsell-Gerdin, Emil, additional, Boman, Kurt, additional, Botond, Fabian, additional, Dotevall, Annika, additional, Graipe, Anna, additional, Jarnet, C, additional, Kaminska, Jessica, additional, Kempe, Anders, additional, Korhonen, Michael, additional, Linderfalk, Carina, additional, Liu, Bo, additional, Ljungstroem, Karl, additional, Ljungström, Karl, additional, Malmqvist, Lennart, additional, Mellbin, Linda, additional, Mooe, Thomas, additional, Nicol, Peter, additional, Norrby, Anders, additional, Ohlsson, Ake, additional, Rosengren, Annika, additional, Saaf, Jan, additional, Salmonsson, Staffan, additional, Strandberg, Olof, additional, Svensson, Karl-Axel, additional, Tengmark, Bengt-Olov, additional, Tsatsaris, Georgios, additional, Ulvenstam, Anders, additional, Vasko, Peter, additional, Chang, Chwen-Tzuei, additional, Chang, Hsin-Mei, additional, Chen, Jung-Fu, additional, Chen, To-Pang, additional, Chung, Ming-Min, additional, Fu, Chia-Po, additional, Hsia, Te-Lin, additional, Hua, Shih-Che, additional, Kuo, Ming-Chun, additional, Lee, Chia-ln, additional, Lee, I-Te, additional, Liang, Kae-Woei, additional, Lin, Shih Yi, additional, Lu, Chieh-Hsiang, additional, Ma, Wen-Ya, additional, Pei, Dee, additional, Shen, Feng-Chih, additional, Su, Ching-Chieh, additional, Su, Shuo-Wei, additional, Tai, Tsai-Sung, additional, Tsai, Wan-Ni, additional, Tsai, Yi-Ting, additional, Tung, Shih-Chen, additional, Wang, Jun-Sing, additional, Yu, Hui-I, additional, Al-Qaissi, Ahmed, additional, Arutchelvam, Vijayaraman, additional, Atkin, Stephen, additional, Au, Simon, additional, Aye, Myint Myint, additional, Bain, Stephen, additional, Bejnariu, Cristina, additional, Bell, Patrick, additional, Bhatnagar, Deepak, additional, Bilous, Rudy, additional, Black, Neil, additional, Brennan, Ursula, additional, Brett, Barbara, additional, Bujanova, Jana, additional, Chow, Elaine, additional, Collier, Andrew, additional, Combe, Amanda, additional, Courtney, Christopher, additional, Courtney, Hamish, additional, Crothers, James, additional, Eavis, Patrick, additional, Elliott, Jackie, additional, Febbraro, Salvatore, additional, Finlayson, Jim, additional, Gandhi, Rajiv, additional, Gillings, Sharon, additional, Hamling, Jonathan, additional, Harper, Roy, additional, Harris, Tim, additional, Hassan, Kahal, additional, Heller, Simon, additional, Jane, Alison, additional, Javed, Zeeshan, additional, Johnson, Tim, additional, Jones, Stephen, additional, Kennedy, Adele, additional, Kerr, David, additional, Kilgallon, Brian, additional, Konya, Judith, additional, Lindsay, John, additional, Lomova-Williams, Lina, additional, Looker, Helen, additional, MacFarlane, David, additional, Macrury, Sandra, additional, Malik, Iqbal, additional, McCrimmon, Rory, additional, McKeith, Douglas, additional, McKnight, John, additional, Mishra, Biswa, additional, Mukhtar, Racha, additional, Mulligan, Ciara, additional, O'Kane, Maurice, additional, Olateju, Tolu, additional, Orpen, Ian, additional, Richardson, Tristan, additional, Rooney, Desmond, additional, Ross, Shorsha Bae, additional, Sathyapalan, Thozhukat, additional, Siddaramaiah, Naveen, additional, Sit, Lee Euan, additional, Stephens, Jeffrey, additional, Turtle, Frances, additional, Wakil, Ammar, additional, Walkinshaw, Emma, additional, Ali, Asem, additional, Anderson, Robert, additional, Arakaki, Richard, additional, Aref, Omar, additional, Ariani, Mehrdad Kevin, additional, Arkin, David, additional, Banarer, Salomon, additional, Barchini, George, additional, Bhan, Arti, additional, Branch, Kelley, additional, Brautigam, Donald, additional, Brietzke, Stephen, additional, Brinas, Maridez, additional, Brito, Yudit, additional, Carter, Casey, additional, Casagni, Kimberely, additional, Casula, Sabina, additional, Chakko, Simon, additional, Charatz, Seth, additional, Childress, Dale, additional, Chow, Lisa, additional, Chustecka, Malgorzata, additional, Clarke, Subha, additional, Cohen, Lisa, additional, Collins, Barry, additional, Colon Vega, Gildred, additional, Comulada-Rivera, Angel, additional, Cortes-Maisonet, Gregorio, additional, Davis, Matthew, additional, de Souza, Jose, additional, Desouza, Cyrus, additional, Dinnan, Mary, additional, Duffy-Hidalgo, Bobbi, additional, Dunn, Barbara, additional, Dunn, Julia, additional, Elman, Marshall, additional, Felicetta, James, additional, Finkelstein, Stuart, additional, Fitz-Patrick, David, additional, Florez, Hermes, additional, Forker, Alan, additional, Fowler, Wayne, additional, Fredrickson, Sonja, additional, Freedman, Zachary, additional, Gainey Narron, Brooke, additional, Gainey-Ferree, Kristin, additional, Gardner, Michael, additional, Gastelum, Christian, additional, Giddings, Stephen, additional, Gillespie, Eve, additional, Gimness, Michael Paul, additional, Goldstein, Gary, additional, Gomes, Maria, additional, Gomez, Nelson, additional, Gorman, Timothy, additional, Goswami, Ketan, additional, Graves, Arthur, additional, Hacking, Scott, additional, Hall, Charles, additional, Hanson, Lenita, additional, Harman, Sherman, additional, Heber, David, additional, Henry, Robert, additional, Hiner, Janette, additional, Hirsch, Irl, additional, Hollander, Priscilla, additional, Hooker, Thomas, additional, Horowitz, Barry, additional, Hoste, Laura, additional, Huang, Loli, additional, Huynh, Minh, additional, Hyman, Dan, additional, Idriss, Soha, additional, Iranmanesh, Ali, additional, Karounos, Dennis, additional, Kashyap, Moti, additional, Katz, Lois, additional, Kaye, William, additional, Khaiton, Yevgeniy, additional, Khardori, Romesh, additional, Kitchen, Timothy, additional, Klein, Andrew, additional, Knffem, Wendi, additional, Kosiborod, Mikhail, additional, Kreglinger, Nicola, additional, Kruger, Davida, additional, Kumar, Anubhav, additional, Laboy, Ivan, additional, Larrabee, Patricia, additional, Larrick, Laura, additional, Lawson, Donna, additional, Ledet, Mike, additional, Lenhard, James, additional, Levy, James, additional, Li, George, additional, Li, Zhaoping, additional, Lieb, David, additional, Limcolioc, April, additional, Lions-Patterson, Jane, additional, Lorber, Daniel, additional, Lorch, Daniel, additional, Lorrello, Michael, additional, Lu, Peter, additional, Lucas, Kathryn Jean, additional, Ma, Siu-Ling, additional, MacAdams, Michael, additional, Magee, Michelle, additional, Magno, Alexander, additional, Mahakala, Aparna Reddy, additional, Marks, Jennifer, additional, McCall, Anthony, additional, McClanahan, William, additional, McClary, Carole, additional, Melendez, Lydia, additional, Melish, John, additional, Michaud, Deanna, additional, Miller, Christopher, additional, Miller, Neil, additional, Mora, Pablo, additional, Moten, Marriyam, additional, Mudaliar, Sunder, additional, Myrick, Gregory, additional, Narayan, Puneet, additional, Nassif, Mike, additional, Neri, Karena, additional, Newton, Tabitha, additional, Niblack, Patricia, additional, Nicol, Philip, additional, Nyenwe, Ebenezer, additional, Odugbesan, A. Ola, additional, Okorocha, Yolanda, additional, Ortiz Carrasquillo, Ramón, additional, Osei, Kwame, additional, Palermo, Coromoto, additional, Patel, Hiren, additional, Patel, Krishna, additional, Pau, Cindy, additional, Perley, Michael, additional, Plevin, Sanford, additional, Plummer, Elena, additional, Powell, Richard, additional, Qintar, Mohammed, additional, Rawls, Rex, additional, Reyes-Castano, John, additional, Reynolds, Lillian, additional, Richards, Robert, additional, Rosenstock, Julio, additional, Rowe, Caroline, additional, Saleh, Jahandar, additional, Sam, Sony, additional, Sanchez, Alfredo, additional, Sander, Donald, additional, Sanderson, Bruce, additional, Savin, Virginia, additional, Seaquist, Elizabeth, additional, Shah, Jayendra, additional, Shi, Serena, additional, Shivaswamy, Vijay, additional, Shlotzhauer, Tammi, additional, Shore, David, additional, Skukowski, Bobbie, additional, Soe, Kyaw, additional, Solheim, Vesna, additional, Soufer, Joseph, additional, Steinberg, Helmut, additional, Steinsapir, Jaime, additional, Tarkington, Phillip, additional, Thayer, Debra, additional, Thomson, Stephen, additional, Thrasher, James, additional, Tibaldi, Joseph, additional, Tjaden, Jeff, additional, Tores, Oberto, additional, Trence, Dace, additional, Trikudanathan, Subbulaxmi, additional, Ullal, Jagdeesh, additional, Uwaifo, Gabriel, additional, Vo, Anthony, additional, Vu, Kenny, additional, Walia, Damandeep, additional, Weiland, Karen, additional, Whitehouse, Fred, additional, Wiegmann, Thomas, additional, Wyne, Kathleen, additional, Wynne, Alan, additional, Yuen, Kevin, additional, Zaretzky, Joel, additional, Zebrack, James, additional, Zieve, Franklin, additional, and Zigrang, William, additional
Published: 2019
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27. The Prevalence of Obstructive Sleep Apnoea in women with Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis

Author: Anna Brown, Ioannis Kyrou, Abd A. Tahrani, Andrew J. Metcalfe, Olalekan A. Uthman, Samantha Johnson, Hassan Kahal, Peter Wall, and Harpal S. Randeva
Subjects: Pediatrics, medicine.medical_specialty, business.industry, Meta-analysis, Medicine, business, Polycystic ovary, Sleep in non-human animals
Published: 2017
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28. Obstructive sleep apnoea and polycystic ovary syndrome ; a comprehensive review of clinical interactions and underlying pathophysiology

Author: Ioannis Kyrou, Harpal S. Randeva, Abd A. Tahrani, and Hassan Kahal
Subjects: medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, Overweight, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Insulin resistance, Internal medicine, medicine, Humans, Obesity, Sleep Apnea, Obstructive, business.industry, Hyperandrogenism, nutritional and metabolic diseases, medicine.disease, Polycystic ovary, female genital diseases and pregnancy complications, nervous system diseases, respiratory tract diseases, 030228 respiratory system, Mood disorders, Female, Insulin Resistance, Metabolic syndrome, medicine.symptom, RG, business, Polycystic Ovary Syndrome, RC
Abstract: Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age. PCOS is associated with multiple co-morbidities including, obesity, insulin resistance and type 2 diabetes, as well as mood disorders and impaired quality of life (QoL). Obstructive sleep apnoea (OSA) is also a common medical condition that is often undiagnosed, particularly in women. OSA is associated with a similar spectrum of comorbidities to that observed in PCOS, including manifestations of the metabolic syndrome and impaired QoL, whilst obesity frequently constitutes a common denominator in the pathophysiology of both OSA and PCOS. Hence, it is not surprising that OSA and PCOS may co-exist in women of reproductive age, and the current clinical guidelines on the management of PCOS recommend screening for OSA symptoms in overweight/obese women with PCOS. In this review, we examine the relationship between OSA and PCOS and explore the potential underlying mechanisms that link these two conditions. This article is protected by copyright. All rights reserved. [Abstract copyright: This article is protected by copyright. All rights reserved.]
Published: 2017

29. Glucagon-like peptide-1 analogue, liraglutide, improves liver fibrosis markers in obese women with polycystic ovary syndrome and nonalcoholic fatty liver disease

Author: Stephen L. Atkin, Anne Marie Coady, Hassan Kahal, Eric S. Kilpatrick, Alan S. Rigby, and G. Abouda
Subjects: Adult, Liver Cirrhosis, medicine.medical_specialty, Cirrhosis, Isoprostane, Endocrinology, Diabetes and Metabolism, chemistry.chemical_compound, Endocrinology, Glucagon-Like Peptide 1, Non-alcoholic Fatty Liver Disease, Weight loss, Internal medicine, Nonalcoholic fatty liver disease, medicine, Humans, Obesity, Triglycerides, medicine.diagnostic_test, business.industry, Liraglutide, Case-control study, medicine.disease, Polycystic ovary, chemistry, Case-Control Studies, Female, medicine.symptom, business, Liver function tests, Polycystic Ovary Syndrome, medicine.drug
Abstract: SummaryIntroduction Nonalcoholic fatty liver disease (NAFLD) has been linked to polycystic ovary syndrome (PCOS) and carries an increased risk of liver cirrhosis. Procollagen type 3 amino-terminal peptide (PIIINP) is an independent predictor of liver cirrhosis. Objective To assess whether 6-month treatment with GLP-1 analogue, liraglutide, improves markers of liver fibrosis. Design A case–control study comparing women with PCOS to age- and weight-matched controls. PCOS was diagnosed according to the Rotterdam criteria. All participants underwent liver function tests and liver ultrasound scan to assess for fatty infiltration. Serum marker for liver fibrosis, PIIINP, was measured at baseline and after 6-month treatment with liraglutide 1·8 mg od. Results Nineteen women with PCOS and 17 controls were recruited, age 32·8 ± 7·2 vs 33·5 ± 6·7 years and weight 100·9 ± 16·7 vs 99·3 ± 14·7 kg, respectively. At baseline, the PCOS group had higher testosterone 1·2 ± 0·3 vs 0·9 ± 0·3 nm (P = 0·01), HOMA-IR 5·1 ± 2·6 vs 3·5 ± 1·3 (P = 0·03), AST 22·4 ± 5·2 vs 18·8 ± 3·4 u/l (P = 0·04), PIIINP 4·4 ± 0·8 vs 3·5 ± 0·8 ug/ml (P = 0·01) and NAFLD seven (35%) vs none (P = 0·005), respectively. Twenty-five (69%) participants completed the study (13 PCOS, 12 controls). Following treatment, weight was reduced by 3·0 ± 4·2 kg (P = 0·01) and 3·8 ± 3·4 kg (P = 0·001), respectively. Similarly, HOMA-IR, hsCRP, triglycerides and urinary isoprostane significantly reduced in both groups. PIIINP significantly reduced the in PCOS group 4·4 ± 0·8 vs 3·7 ± 0·9 ug/ml (P
Published: 2013
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30. A case of reversible elevation in liver enzymes in a patient with poorly controlled type 1 diabetes

Author: Hassan Kahal, Nneka Obisi, Belinda Allan, and Adam Al-Hakim
Subjects: Elevation (emotion), Type 1 diabetes, medicine.medical_specialty, Endocrinology, business.industry, Liver enzyme, Internal medicine, Medicine, business, medicine.disease
Published: 2016
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31. A retrospective study assessing the effects of OSA in women with PCOS attending the weight management clinic

Author: Abd A. Tahrani, George K. Dimitriadis, Ioannis Kyrou, Harpal S. Randeva, Asad Ali, and Hassan Kahal
Subjects: Pediatrics, medicine.medical_specialty, business.industry, Weight management, Medicine, Retrospective cohort study, business
Published: 2016
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32. The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism

Author: R.J.A. England, Stephen L. Atkin, Alan S. Rigby, Thozhukat Sathyapalan, Mo Aye, and Hassan Kahal
Subjects: Parathyroidectomy, Thyroid nodules, medicine.medical_specialty, Hyperparathyroidism, business.industry, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Case-control study, medicine.disease, Asymptomatic, Endocrinology, Internal medicine, Medicine, medicine.symptom, business, Prospective cohort study, Primary hyperparathyroidism, Depression (differential diagnoses)
Abstract: Summary Background With increased biochemical screening, primary hyperparathyroidism (pHPT) is often discovered incidentally whilst patients are asymptomatic. Objective To assess the impact of parathyroidectomy on neuropsychological symptoms and biochemical parameters in people with asymptomatic pHPT, whilst controlling for the surgical procedure. Patients/design/measurements Twenty-four patients with asymptomatic pHPT requiring parathyroidectomy, in accordance with National Institutes for Health recommendations, were recruited prospectively. A control group of 23 subjects was recruited simultaneously from consecutive patients undergoing diagnostic hemithyroidectomy (HT) for benign thyroid nodules. Operations were performed by a single surgeon. Biochemical investigations and neuropsychological symptoms were measured preoperatively and 3 months after surgery. Neuropsychological symptoms were measured using the Hospital Anxiety (HAD-A) and Depression (HAD-D) scales and the Mood Rating Scale (MRS). Results Postoperatively, calcium and parathyroid hormone normalized in all patients in the pHPT group. Patients with pHPT showed a significant improvement in neuropsychological symptoms with a pre- and postoperative mean change of 2·45 ± 2·57 (P
Published: 2012
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33. The management of hyponatraemia at two district general hospitals in the UK

Author: Jeanette Anders, Abd A. Tahrani, Hassan Kahal, Peter Daggett, Haroon Siddique, Batsi Chikura, Rajeev Kaja, Rebecca Shankland, and Kevin J Hardy
Subjects: medicine.medical_specialty, business.industry, Health Policy, Emergency medicine, Public Health, Environmental and Occupational Health, Medicine, Medical emergency, business, medicine.disease
Published: 2010
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34. Preoperative parathyroid imaging: a retrospective audit

Author: Hassan Kahal, Natalie Winfield, Frank Agada, and Vijay Jayagopal
Subjects: medicine.medical_specialty, Parathyroid imaging, business.industry, Medicine, Radiology, Audit, business
Published: 2015
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35. A reversible rise in the total cholesterol to HDL ratio in a body builder

Author: Hassan Kahal, Eric S. Kilpatrick, Deepa Narayanan, and Kamrudeen Mohammed
Subjects: medicine.medical_specialty, business.industry, Cholesterol, Endocrinology, Diabetes and Metabolism, medicine.disease, Elevated total cholesterol, Lipid-lowering therapy, chemistry.chemical_compound, Endocrinology, chemistry, Risk indicator, HDL/cholesterol ratio, Internal medicine, Total cholesterol, Diabetes mellitus, Internal Medicine, medicine, lipids (amino acids, peptides, and proteins), Risk factor, Cardiology and Cardiovascular Medicine, business
Abstract: Introduction Low HDL-cholesterol concentration is one of the defining abnormalities of metabolic syndrome1 and an independent risk factor for CHD. Total cholesterol/HDL ratio is regarded as a better cardiovascular risk indicator than sole total cholesterol concentrations. The JBS-2 guidelines identify patients with an elevated total cholesterol to HDL cholesterol ratio ≥6.0, as a threshold for initiation of lipid lowering therapy in combination with intensive lifestyle changes. We report a case of raised cholesterol/HDL ratio, in which treating the underlying aetiology led to the resolution of the biochemical abnormality.
Published: 2012
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36. The effects of treatment with Liraglutide on atherothrombotic risk in obese young women with polycystic ovary syndrome and controls

Author: Eric S. Kilpatrick, Rebecca V. Vince, Stephen L. Atkin, Alan S. Rigby, Anne Marie Coady, Hassan Kahal, Tamas Ungvari, Khalid M. Naseem, Ahmed Aburima, and Ramzi A. Ajjan
Subjects: Adult, Blood Platelets, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Urinary system, Carotid Intima-Media Thickness, Young Adult, chemistry.chemical_compound, Insulin resistance, Glucagon-Like Peptide 1, Risk Factors, Weight loss, Diabetes mellitus, Internal medicine, PCOS, Humans, Hypoglycemic Agents, Medicine, Obesity, Young adult, Reactive hyperemia, Triglyceride, business.industry, Liraglutide, Fibrinolysis, General Medicine, Middle Aged, medicine.disease, Polycystic ovary, Confidence interval, Endocrinology, chemistry, Cardiovascular Diseases, cIMT, Female, Platelet function, Insulin Resistance, medicine.symptom, business, Polycystic Ovary Syndrome, Research Article, medicine.drug
Abstract: Background Polycystic ovary syndrome (PCOS) is associated with obesity and increased cardiovascular (CV) risk markers. In this study our aim was to assess the effects of six months treatment with liraglutide 1.8 mg od on obesity, and CV risk markers, particularly platelet function, in young obese women with PCOS compared to controls of similar age and weight. Methods Carotid intima-media wall thickness (cIMT) was measured by B-mode ultrasonography, platelet function by flow cytometry, clot structure/lysis by turbidimetric assays and endothelial function by ELISA and post-ischaemic reactive hyperemia (RHI). Data presented as mean change (6-month – baseline) ± standard deviation. Results Nineteen obese women with PCOS and 17 controls, of similar age and weight, were recruited; baseline atherothrombotic risk markers did not differ between the two groups. Twenty five (69.4%) participants completed the study (13 PCOS, 12 controls). At six months, weight was significantly reduced by 3.0 ± 4.2 and 3.8 ± 3.4 kg in the PCOS and control groups, respectively; with no significant difference between the two groups, P = 0.56. Similarly, HOMA-IR, triglyceride, hsCRP, urinary isoprostanes, serum endothelial adhesion markers (sP-selectin, sICAM and sVCAM), and clot lysis area were equally significantly reduced in both groups compared to baseline. Basal platelet P-selectin expression was significantly reduced at six months in controls −0.17 ± 0.26 but not PCOS −0.12 ± 0.28; between groups difference, 95% confidence interval = −0.14 – 0.26, P = 0.41. No significant changes were noted in cIMT or RHI. Conclusions Six months treatment with liraglutide (1.8 mg od) equally affected young obese women with PCOS and controls. In both groups, liraglutide treatment was associated with 3–4% weight loss and significant reduction in atherothrombosis markers including inflammation, endothelial function and clotting. Our data support the use of liraglutide as weight loss medication in simple obesity and suggest a potential beneficial effect on platelet function and atherothrombotic risk at 6 months of treatment. Trial registration Clinical trial reg. no. ISRCTN48560305. Date of registration 22/05/2012.
Published: 2014
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37. Polycystic ovary syndrome has no independent effect on vascular, inflammatory or thrombotic markers when matched for obesity

Author: Tamas Ungvari, Stephen L. Atkin, Khalid M. Naseem, Ramzi A. Ajjan, Ahmed Aburima, Anne Marie Coady, Hassan Kahal, Eric S. Kilpatrick, Rebecca V. Vince, Alan S. Rigby, and Alison J. Dawson
Subjects: Adult, Blood Platelets, medicine.medical_specialty, Isoprostane, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Prostacyclin, Isoprostanes, Carotid Intima-Media Thickness, Hyperaemia, chemistry.chemical_compound, Basal (phylogenetics), Endocrinology, Risk Factors, Internal medicine, Fibrinolysis, medicine, Humans, Platelet, Obesity, business.industry, Fibrinogen binding, Platelet Activation, Polycystic ovary, chemistry, Cardiovascular Diseases, Female, Endothelium, Vascular, medicine.symptom, Insulin Resistance, business, medicine.drug, Polycystic Ovary Syndrome
Abstract: SummaryIntroduction Previous studies investigating cardiovascular (CV) risk in obese women with polycystic ovary syndrome (PCOS) have been potentially confounded by not adequately accounting for body weight. Objective To assess if PCOS increases CV risk independently in young obese women by examining carotid intima-media wall thickness (cIMT) and platelet function. Design A case–control study comparing women with PCOS (n = 21) to age (32·8 ± 7·2 vs 33·5 ± 6·7 years), and weight (100·9 ± 16·7 vs 99·3 ± 14·7 kg)-matched controls (n = 19). Platelet function was examined by flow cytometry, clot structure and fibrinolysis by turbidimetric assays and endothelial function by ELISA and post ischaemic reactive hyperaemia. Results The PCOS group had higher testosterone 1·2 ± 0·3 vs 0·9 ± 0·3 nmol/l (P = 0·01), HOMA-IR 2·5 ± 1·7 vs 1·7 ± 1·0 (P = 0·08), impaired glucose regulation 33·3% vs 5·3% (P = 0·02), and urinary isoprostane 16·0 ± 4·4 vs 11·8 ± 7·1 ng/ml (P = 0·04) compared to controls. Mean cIMT 0·5 ± 0·05 vs 0·48 ± 0·06 mm (P = 0·36), and basal platelet surface expression (percentage of positive cells) of P-selectin 0·52 ± 0·3 vs 0·43 ± 0·23 (P = 0·40) and fibrinogen binding 0·97 ± 0·4 vs 0·83 ± 0·3 (P = 0·48) did not significantly differ between the PCOS and control groups respectively. Furthermore, platelets sensitivity to stimulation with adenosine-5′-diphosphate or inhibition with prostacyclin, clot structure and fibrinolytic efficiency ex vivo, endothelial reactive hyperaemic index (RHI), inflammation (hsCRP) and adhesion markers (sE-selectin, sP-selectin, sVCAM-1 and sICAM-1) were not significantly different between the two groups. Conclusions PCOS appeared not to independently increase atherothrombotic risk when matched for obesity. It is likely that any excess CV risk in young obese women with PCOS can either be attributed to obesity or is not yet apparent at this early stage of the condition.
Published: 2012

38. The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism

Author: Hassan, Kahal, Mo, Aye, Alan S, Rigby, Thozhukat, Sathyapalan, R J A, England, and Stephen L, Atkin
Subjects: Adult, Male, Parathyroidectomy, Depression, Case-Control Studies, Humans, Female, Prospective Studies, Anxiety, Middle Aged, Hyperparathyroidism, Primary, Aged
Abstract: With increased biochemical screening, primary hyperparathyroidism (pHPT) is often discovered incidentally whilst patients are asymptomatic.To assess the impact of parathyroidectomy on neuropsychological symptoms and biochemical parameters in people with asymptomatic pHPT, whilst controlling for the surgical procedure. PATIENTS/DESIGN/MEASUREMENTS: Twenty-four patients with asymptomatic pHPT requiring parathyroidectomy, in accordance with National Institutes for Health recommendations, were recruited prospectively. A control group of 23 subjects was recruited simultaneously from consecutive patients undergoing diagnostic hemithyroidectomy (HT) for benign thyroid nodules. Operations were performed by a single surgeon. Biochemical investigations and neuropsychological symptoms were measured preoperatively and 3 months after surgery. Neuropsychological symptoms were measured using the Hospital Anxiety (HAD-A) and Depression (HAD-D) scales and the Mood Rating Scale (MRS).Postoperatively, calcium and parathyroid hormone normalized in all patients in the pHPT group. Patients with pHPT showed a significant improvement in neuropsychological symptoms with a pre- and postoperative mean change of 2·45 ± 2·57 (P0·05) on HAD-A, 2·79 ± 3·85 (P0·05) on HAD-D, and 3·2 ± 4·57 (P0·05) on MRS, parameters that were unaltered in the HT group. The differences between the two groups remained statistically significant after adjustment for age and sex for HAD-D (mean change 2·8, 95% CI = 0·3, 5·3, P = 0·025) and MRS (mean difference 3·5, 95% CI = 0·4, 6·7, P = 0·027) but not for HAD-A (mean difference 1·5, 95% CI = -0·8, 3·8, P = 0·20). For all three mental health scores, there were no significant associations with either age or sex.Asymptomatic pHPT is associated with neuropsychological symptoms that improve after parathyroidectomy.
Published: 2011

39. Pharmacological Treatment of Obesity in Patients with Polycystic Ovary Syndrome

Author: Stephen L. Atkin, Thozhukat Sathyapalan, and Hassan Kahal
Subjects: medicine.medical_specialty, lcsh:Internal medicine, endocrine system diseases, business.industry, Endocrinology, Diabetes and Metabolism, nutritional and metabolic diseases, Reproductive age, Review Article, medicine.disease, Bioinformatics, Obesity, Polycystic ovary, female genital diseases and pregnancy complications, Pharmacological treatment, Pathogenesis, Endocrinology, Weight loss, Internal medicine, medicine, In patient, medicine.symptom, business, lcsh:RC31-1245
Abstract: Polycystic ovary syndrome (PCOS) is a common disorder affecting women of reproductive age and it is associated with increased cardiovascular risk. Obesity plays an important role in the pathogenesis of PCOS, and the majority of patients with PCOS are obese. Over the last 20 years, the prevalence of obesity has dramatically increased, with probable associated increase in PCOS. Weight reduction plays an integral part in the management of women with PCOS. In this paper, current available weight reduction therapies in the management of PCOS are discussed.
Published: 2011

40. The management of hyponatraemia at two district general hospitals in the UK

Author: Haroon, Siddique, Hassan, Kahal, Abd A, Tahrani, Batsi, Chikura, Rebecca, Shankland, Jeanette, Anders, Rajeev, Kaja, Kevin, Hardy, and Peter, Daggett
Subjects: Adult, Aged, 80 and over, Male, Medical Audit, Humans, Female, Middle Aged, Practice Patterns, Physicians', Hospitals, General, United Kingdom, Aged, Hyponatremia, Retrospective Studies
Published: 2010

41. P0598 PANHYPOPITUITARISM AFTER NON-PITUITARY BRAIN SURGERY

Author: Mohamed Malik, Kayvan Khadjooi, Salah Mahmoud, and Hassan Kahal
Subjects: medicine.medical_specialty, business.industry, Internal Medicine, Medicine, business, Surgery
Published: 2009
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42. P0219 EMPIRIC ANTIBIOTIC THERAPY IN ACUTE MEDICAL ADMISSIONS – DO WE ADHERE TO ANTIBIOTIC POLICY?

Author: Peter Cowling, Gek Shim, Kayvan Khadjooi, Hassan Kahal, and Stuart Baugh
Subjects: medicine.medical_specialty, business.industry, medicine.drug_class, Antibiotic therapy, Emergency medicine, Antibiotics, Internal Medicine, medicine, Intensive care medicine, business
Published: 2009
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43. A reversible rise in the total cholesterol to HDL ratio in a body builder.

Author: Deepa Narayanan, Hassan Kahal, Kamrudeen Mohammed, and Eric S Kilpatrick
Published: 2012

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