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2. Outcomes from a mechanistic biomarker multi-arm and randomised study of liposomal MTP-PE (Mifamurtide) in metastatic and/or recurrent osteosarcoma (EuroSarc-Memos trial)

Author

Barnes, David J., Dutton, Peter, Bruland, Øyvind, Gelderblom, Hans, Faleti, Ade, Bühnemann, Claudia, van Maldegem, Annemiek, Johnson, Hannah, Poulton, Lisa, Love, Sharon, Tiemeier, Gesa, van Beelen, Els, Herbschleb, Karin, Haddon, Caroline, Billingham, Lucinda, Bradley, Kevin, Ferrari, Stefano, Palmerini, Emanuela, Picci, Piero, Dirksen, Uta, Strauss, Sandra J., Hogendoorn, Pancras C. W., Buddingh, Emmeline, Blay, Jean-Yves, Cleton-Jansen, Anne Marie, and Hassan, Andrew Bassim

Published
2022
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3. Id1,Spp1andPak3are biomarkers ofSmad4and TGF-β1 dependency in conditional intestinal adenoma, organoids and colorectal cancer.

Author

Surakhy, Mirvat, primary, Matheson, Julia, additional, Barnes, David, additional, Carter, Emma, additional, Hughes, Jennifer, additional, Bühnemann, Claudia, additional, Sanegre, Sabina, additional, Morreau, Hans, additional, Metz, Paul, additional, Imianowski, Charlotte J., additional, and HASSAN, Andrew Bassim, additional

Published
2024
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4. Challenges and solutions to system-wide use of precision oncology as the standard of care paradigm

Author

Lajmi, Nesrine, primary, Alves-Vasconcelos, Sofia, additional, Tsiachristas, Apostolos, additional, Haworth, Andrew, additional, Woods, Kerrie, additional, Crichton, Charles, additional, Noble, Theresa, additional, Salih, Hizni, additional, Várnai, Kinga A., additional, Branford-White, Harriet, additional, Orrell, Liam, additional, Osman, Andrew, additional, Bradley, Kevin M., additional, Bonney, Lara, additional, McGowan, Daniel R., additional, Davies, Jim, additional, Prime, Matthew S., additional, and Hassan, Andrew Bassim, additional

Published
2024
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7. New indicators and indexes for benchmarking university–industry–government innovation in medical and life science clusters: results from the European FP7 Regions of Knowledge HealthTIES project

Author

Edmunds, Laurel D., Gluderer, Silvia, Ovseiko, Pavel V., Kamerling, Roel, Ton, Jacqueline, Vis, Laura, Jenni, Mario, Tutton, Gregory, Lawton-Smith, Helen, Nadabán, Márta Völgyiné, Rab, Máté, Rees, Jon, Anson, John, Rushforth, Alexander D., Allen, Maxine, Buchan, Alastair M., Vendrell, Montserrat, Casta, Alex, Mehes, Gábor, Hogendoorn, Pancras C. W., Hafen, Ernst, and Hassan, A. Bassim

Published
2019
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15. Additional file 1 of Outcomes from a mechanistic biomarker multi-arm and randomised study of liposomal MTP-PE (Mifamurtide) in metastatic and/or recurrent osteosarcoma (EuroSarc-Memos trial)

Author

Barnes, David J., Dutton, Peter, Bruland, Øyvind, Gelderblom, Hans, Faleti, Ade, Bühnemann, Claudia, van Maldegem, Annemiek, Johnson, Hannah, Poulton, Lisa, Love, Sharon, Tiemeier, Gesa, van Beelen, Els, Herbschleb, Karin, Haddon, Caroline, Billingham, Lucinda, Bradley, Kevin, Ferrari, Stefano, Palmerini, Emanuela, Picci, Piero, Dirksen, Uta, Strauss, Sandra J., Hogendoorn, Pancras C. W., Buddingh, Emmeline, Blay, Jean-Yves, Cleton-Jansen, Anne Marie, and Hassan, Andrew Bassim

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2022
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17. Additional file 2 of Outcomes from a mechanistic biomarker multi-arm and randomised study of liposomal MTP-PE (Mifamurtide) in metastatic and/or recurrent osteosarcoma (EuroSarc-Memos trial)

Author

Barnes, David J., Dutton, Peter, Bruland, Øyvind, Gelderblom, Hans, Faleti, Ade, Bühnemann, Claudia, van Maldegem, Annemiek, Johnson, Hannah, Poulton, Lisa, Love, Sharon, Tiemeier, Gesa, van Beelen, Els, Herbschleb, Karin, Haddon, Caroline, Billingham, Lucinda, Bradley, Kevin, Ferrari, Stefano, Palmerini, Emanuela, Picci, Piero, Dirksen, Uta, Strauss, Sandra J., Hogendoorn, Pancras C. W., Buddingh, Emmeline, Blay, Jean-Yves, Cleton-Jansen, Anne Marie, and Hassan, Andrew Bassim

Subjects
Data_FILES
Abstract

Additional file 2.

Published
2022
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20. Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7–11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9

Author

Bochel, Alice J., primary, Williams, Christopher, additional, McCoy, Airlie J., additional, Hoppe, Hans-Jürgen, additional, Winter, Ashley J., additional, Nicholls, Ryan D., additional, Harlos, Karl, additional, Jones, E. Yvonne, additional, Berger, Imre, additional, Hassan, A. Bassim, additional, and Crump, Matthew P., additional

Published
2020
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22. Visualization of replication factories attached to a nucleoskeleton

Author

Hozak, Pavel, Hassan, A. Bassim, Jackson, Dean A., and Cook, Peter R.

Subjects
Chromosome replication -- Analysis, DNA, Biological sciences
Abstract

A homogenous population of replication sites was studied by concentrating HeLa cells in early S phase, encapsulating these with agarose microbeads, permeabilizing them with streptolysin O and incubating the cells in a physiologic buffer with biotin-11-d UTP. DNA synthesis sites were then immunolabeled. Electron microscopy revealed that labeled DNA moves through a replication factory while being attached to a nucleoskeleton.

Published
1993

23. Diagnostic value of H3F3A mutations in giant cell tumour of bone compared to osteoclast‐rich mimics

Author

Presneau, Nadège, Baumhoer, Daniel, Behjati, Sam, Pillay, Nischalan, Tarpey, Patrick, Campbell, Peter J, Jundt, Gernot, Hamoudi, Rifat, Wedge, David C, Loo, Peter Van, Hassan, A Bassim, Khatri, Bhavisha, Ye, Hongtao, Tirabosco, Roberto, Amary, M Fernanda, and Flanagan, Adrienne M

Subjects
giant cell granuloma, giant cell tumour of bone, USP6, malignant giant cell tumour of bone, Original Article, Original Articles, H3F3B, H3F3A, solid variant of aneurysmal bone cyst
Abstract

Driver mutations in the two histone 3.3 (H3.3) genes, H3F3A and H3F3B, were recently identified by whole genome sequencing in 95% of chondroblastoma (CB) and by targeted gene sequencing in 92% of giant cell tumour of bone (GCT). Given the high prevalence of these driver mutations, it may be possible to utilise these alterations as diagnostic adjuncts in clinical practice. Here, we explored the spectrum of H3.3 mutations in a wide range and large number of bone tumours (n = 412) to determine if these alterations could be used to distinguish GCT from other osteoclast‐rich tumours such as aneurysmal bone cyst, nonossifying fibroma, giant cell granuloma, and osteoclast‐rich malignant bone tumours and others. In addition, we explored the driver landscape of GCT through whole genome, exome and targeted sequencing (14 gene panel). We found that H3.3 mutations, namely mutations of glycine 34 in H3F3A, occur in 96% of GCT. We did not find additional driver mutations in GCT, including mutations in IDH1, IDH2, USP6, TP53. The genomes of GCT exhibited few somatic mutations, akin to the picture seen in CB. Overall our observations suggest that the presence of H3F3A p.Gly34 mutations does not entirely exclude malignancy in osteoclast‐rich tumours. However, H3F3A p.Gly34 mutations appear to be an almost essential feature of GCT that will aid pathological evaluation of bone tumours, especially when confronted with small needle core biopsies. In the absence of H3F3A p.Gly34 mutations, a diagnosis of GCT should be made with caution.

Published
2015

24. Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR

Author

Aleksic, Tamara, Browning, Lisa, Woodward, Martha, Phillips, Rachel, Page, Suzanne, Henderson, Shirley, Athanasou, Nicholas, Ansorge, Olaf, Whitwell, Duncan, Pratap, Sarah, Hassan, A. Bassim, Middleton, Mark R., and Macaulay, Valentine M.

Subjects
tyrosine kinase inhibitor, Oncology, EGFR, nuclear IGF-1R, Case Report, chordoma, IGF-1R
Abstract

Chordomas are rare primary malignant bone tumors arising from embryonal notochord remnants of the axial skeleton. Chordomas commonly recur following surgery and radiotherapy, and there is no effective systemic therapy. Previous studies implicated receptor tyrosine kinases including epidermal growth factor receptor (EGFR) and type 1 insulin-like growth factor receptor (IGF-1R) in chordoma biology. We report an adult female patient who presented in 2003 with spinal chordoma, treated with surgery and radiotherapy. She underwent further surgery for recurrent chordoma in 2008, with subsequent progression in pelvic deposits. In June 2009 she was recruited onto the Phase I OSI-906-103 trial of EGFR inhibitor erlotinib with linsitinib, a novel inhibitor of IGF-1R/insulin receptor (INSR). Treatment with 100mg QD erlotinib and 50mg QD linsitinib was well-tolerated, and after 18 months a partial response was achieved by RECIST criteria. From 43 months a protocol modification allowed intra-patient linsitinib dose-escalation to 50mg BID. The patient remained stable on trial treatment for a total of five years, discontinuing treatment in August 2014. She subsequently experienced further disease progression for which she underwent pelvic surgery in April 2015. Analysis of DNA extracted from 2008 (pre-trial) tissue showed that the tumor harbored wild-type EGFR, and a PIK3CA mutation was detected in plasma but not tumor DNA. The 2015 (post-trial) tumor harbored a mutation of uncertain significance in ATM, with no detectable mutations in other components of a 50 gene panel including EGFR, PIK3CA and TP53. By immunohistochemistry the tumor was positive for brachyury, the molecular hallmark of chordoma, and showed weak-moderate membrane and cytoplasmic EGFR. IGF-1R was detected in the plasma membrane and cytoplasm and was expressed more strongly in recurrent tumor than the primary. We also noted heterogeneous nuclear IGF-1R, which has been linked with sensitivity to IGF-1R inhibition. Similar variation in IGF-1R expression and subcellular localization was noted in 15 further cases of chordoma. In summary, this exceptionally durable response suggests that there may be merit in evaluating combined IGF-1R/INSR and EGFR inhibition in patients with chordomas that recur following failure of local treatment.

Published
2016
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26. A phase I/II dose escalation and expansion study of cabiralizumab (cabira; FPA-008), an anti-CSF1R antibody, in tenosynovial giant cell tumor (TGCT, diffuse pigmented villonodular synovitis D-PVNS).

Author

Sankhala, Kamalesh Kumar, primary, Blay, Jean-Yves, additional, Ganjoo, Kristen N., additional, Italiano, Antoine, additional, Hassan, Andrew Bassim, additional, Kim, Tae Min, additional, Ravi, Vinod, additional, Cassier, Philippe Alexandre, additional, Rutkowski, Piotr, additional, Sankar, Neil, additional, Qazi, Ibrahim, additional, Sikorski, Robert S., additional, Collins, Helen, additional, Zhang, Charlie, additional, Shocron, Ellyn, additional, and Gelderblom, Hans, additional

Published
2017
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28. Contributors

Author

Abelson, Abby G., Abramson, Steven B., Adachi, Jonathan D., Adams, Michael A., Aggarwal, Rohit, Aigner, Thomas, Akira, Shizuo, Albert, Daniel A., Aletaha, Daniel, Alevizos, Ilias, Allem, Kavitta B., Almehthel, Mohammed, Almohaya, Mohamed, Alonso, Elena Riera, Amigo, Mary-Carmen, Arden, Nigel K., Aringer, Martin, Arkema, Elizabeth V., Ascherman, Dana P., Atamas, Sergei P., Atkinson, Timothy J., Azeez, Maha A., Azevedo, Pedro M., Baer, Alan N., Baeten, Dominique, Baines, Colin P., Balsa, Alejandro, Baraliakos, Xenofon, Bardin, Thomas, Barnes, Jammie K., Barnsley, Les, Barr, Andrew J., Bathon, Joan M., Bauch, Angela, Bay-Jensen, Anne-Christine, Belch, Jill J.F., Bellamy, Nicholas, Bellido, Teresita, Benjamin, Michael, Bennell, Kim L., Beresford, Michael W., Berman, Brian, Bermas, Bonnie L., Bertsias, George, Bhalla, Sonal, Bilginer, Yelda, Birnbaum, Julius, Bleasel, Jane F., Block, Joel A., Blom, Ashley W., Böhm, Markus, Bonelli, Michael, Borchert, Grace, Boros, Christina A., Boumpas, Dimitrios T., Bozec, Aline, Brasington, Richard D., Jr., Braun, Jürgen, Brouwer, Elisabeth, Brown, Jacques P., Brown, Matthew A., Bruce, Ian N., Buch, Maya H., Buckley, Christopher D., Bugbee, William D., Burmester, Gerd-Rüdiger, Burns, Jane C., Burr, David B., Buttgereit, Frank, Bykerk, Vivian P., Calabrese, Leonard H., Callen, Jeffrey P., Carr, Andrew J., Carroll, Graeme J., Cavallo, Sabrina, Cervera, Ricard, Chaudhary, Prateek, Choi, Hyon K., Choy, Ernest H., Christopher-Stine, Lisa, Chu, Alvina D., Chung, Lorinda, Ciccia, Francesco, Clauw, Daniel J., Clinch, Jacqui, Clowse, Megan E.B., Coghlan, J. Gerard, Colbert, Robert A., Conaghan, Philip G., Cooper, Cyrus, Cooper, Robert G., Costenbader, Karen H., Cox, George L.D., Creamer, Paul, Cronstein, Bruce N., Cross, Raymond, Cutolo, Maurizio, D’Adamo, Chris, D’Agati, Vivette D., Daikh, David I., Dakin, Stephanie G., Dalbeth, Nicola, Davis, Aileen M., D’Cruz, David P., Ceulaer, Karel De, Rheum, Dipl, de Jesus, Adriana A., De Vita, Salvatore, de Wit, Maarten, Deal, Chad L., Deane, Kevin D., Dellaripa, Paul F., Dennison, Elaine, Denton, Christopher P., Dieppe, Paul, Dolan, Patricia, Doyle, Tracy J., Dyer, George S.M., Emery, Paul, Espinosa, Gerard, Espinoza, Luis R., Eyre, Stephen, Fanouriakis, Antonis C., Farber, Joshua, Fasth, Anders, Feist, Eugen, Feldman, Candace H., Feldman, Debbie, Filer, Andrew, Fiorentino, David F., Fisher, Benjamin A., Fisk, John D., Flores, Raymond H., Forbess, Lindsy, Fox, David A., Freemont, Anthony J., Fricka, Kevin B., Gabay, Cem, Gadina, Massimo, Gandolfo, Saviana, Gauntlett-Gilbert, Jeremy, Gay, Steffen, Gensler, Lianne S., Gerlag, Danielle M., Gold, Garry E., Goldbach-Mansky, Raphaela, Goldingay, Sarah J., Gómez-Puerta, José A., Goodman, Susan M., Gordon, Caroline, Gordon, Sharon M., Gorodkin, Rachel, Görtz, Simon, Grainger, Andrew J., Gravallese, Ellen M., Greenberg, Jeffrey D., Grieve, Sharon, Guilherme, Luiza, Gül, Ahmet, Gupta, Sarthak, Hagan, Matilda, Hagley, Karlene, Han, Shuhong, Hanly, John G., Hanson, Eric P., Haraoui, Boulos, Hardcastle, Sarah A., Harley, John B., Haroun, Tayseer G., Hashkes, Philip J., Hassan, Andrew Bassim, Haupt, Lukas, Hawker, Gillian A., Hawkins, Philip N., Heeringa, Peter, Heiberg, Turid, Heinegård, Dick, Helfgott, Simon M., Henriksen, Kim, Hinman, Rana S., Ho, Pauline Y.P., Hochberg, Marc C., Hoffmann, Markus H., Holick, Michael F., Holroyd, Christopher R., Holt, Cathy, Huizinga, Thomas W.J., Husni, M. Elaine, Inman, Robert D., Inoue, Dai, Isaac, Zacharia, Isaacs, John D., Iversen, Maura D., Jabs, Douglas A., Jaimungal, Sarada, James, Judith A., Javaid, M. Kassim, Javidan, Pooya, Javier, Rose-Marie, Jefferis, Roy, Johnsen, Alyssa K., Jordan, Joanne M., Joyce, Andrew A., Jung, Michelle, Kado, Ruba, Kaisho, Tsuneyasu, Kallenberg, Cees G.M., Kane, David, Kaplan, Mariana J., Karsdal, Morten Asser, Kassimos, Dimitrios G., Kastner, Daniel L., Kawano, Mitsuhiro, Kay, Jonathan, Keating, Richard M., Kelly, Jennifer A., Kendler, David, Khamashta, Munther A., Khan, Irfan R., Khanna, Dinesh, Klokkerud, Mari, Kolstad, Kathleen D., Kottyan, Leah, Kraus, Virginia Byers, Kvien, Tore K., Lafyatis, Robert, Landewé, Robert B.M., Langford, Carol A., Lau, Arthur N., Lavin, Robert A., Laxer, Ronald M., Learch, Thomas J., Leatherwood, Cianna, Lewis, Jennifer S., Lewith, George, Liao, Katherine P., Lightfoot, Adam P., Littlejohn, Geoffrey O., Lorenzo, Pilar, Lories, Rik J.U., Luger, Thomas A., Lundberg, Ingrid E., Luqmani, Raashid A., Lythgoe, Hanna M., MacDougall, Kristin J., MacKenzie, C. Ronald, Manasson, Julia, Mangham, David Charles, Mao, Rong, March, Lyn M., Marqués, Alejandro Olivé, Márquez, Javier, Martín-Mola, Emilio, Martínez-Lavín, Manuel, Matteson, Eric L., Matzat, Stephen J., Mayes, Maureen D., McAlindon, Timothy, McCabe, Candy S., McCarthy, Edward F., McCarthy, Geraldine M., McDermott, Michael F., McGonagle, Dennis, McLean, Lachy, Ian Melville, Andrew Robert, Michou, Laëtitia, Middleton, Rob, Mikdashi, Jamal A., Miller, Frederick W., Miller, Paul D., Minden, Kirsten, Miner, Jonathan J., Moe, Rikke Helene, Möller, Ingrid, Monach, Paul A., Mons, Barend, Myasoedova, Elena, Nam, Jackie L., Namur, Gauthier, Naredo, Esperanza, Neerinckx, Barbara, Nelson, Amanda E., Nicolson, Philippa J.A., Nieves, César E. Fors, Nordal, Ellen B., Nöth, Ulrich, Ntatsaki, Eleana, Oddis, Chester V., Omar, Ahmed, Ombrello, Michael J., Omisade, Antonina, Ong, Voon H., Önnerfjord, Patrik, Orcel, Philippe, Orr, Carl, O'Shea, John J., Ospelt, Caroline, Özen, Seza, Parker, Matthew J.S., Patrono, Carlo, Pilkington, Clarissa A., Pillinger, Michael H., Pineda, Carlos, Pipitone, Nicolò, Poddubnyy, Denis, Pope, Janet E., Postolova, Anna, Price, Andrew, Quartuccio, Luca, Rackwitz, Lars, Radner, Helga, Raychaudhuri, Soumya, Redmond, Anthony C., Rees, Jonathan L., Reeves, Westley H., Rehaume, Linda M., Remmers, Elaine F., Requena, Luis, Reynolds, Gary, Ribbens, Clio, Richards, Bethan, Richardson, Bruce C., Richette, Pascal, Richter, Adrian, Ritchlin, Christopher T., Ritter, Susan Y., Robinson, William H., Rogers, Valerie, Rosas, Ivan O., Rosenthal, Ann K., Rowan, Andrew D., Rudwaleit, Martin, Rull, Marina, Rygg, Marite, Saag, Kenneth G., Salmon, Jane E., Salter, Donald M., Salvarani, Carlo, Sandell, Linda J., Sandigursky, Sabina, Saxne, Tore, Schaible, Hans-Georg, Scher, Jose U., Schett, Georg, Schiffenbauer, Adam I., Schiller, Alan L., Schlesinger, Naomi, Schreiber, Benjamin E., Schwartz, Daniella Muallem, Shapiro, Lauren M., Sharma, Leena, Siaton, Bernadette C., Siegel, Richard M., Sieper, Joachim, Simard, Julia Fridman, Simmons, Barry P., Simms, Robert W., Singer, Nora G., Smith, Judith A., Smith, Stacy E., Smolen, Josef S., Solomon, Daniel H., Stack, John, Stanley, David, Steen, Virginia D., Steere, Allen C., Steiner, Günter, Steinert, Andre F., Stojan, George, Strand, Vibeke, Straub, Rainer H., Streeten, Elizabeth A., Superti-Furga, Giulio, Tak, Paul P., Tang, Chen, Taylor, Peter C., Terkeltaub, Robert, Thomas, Beje, Thomas, Ranjeny, Thorne, Jennifer E., Tobias, Jonathan H., Tremoulet, Adriana H., Trouw, Leendert A., Tuan, Rocky S., Turesson, Carl, Umehara, Hisanori, Valdes, Ana M., van der Heijde, Désirée, van Vollenhoven, Ronald F., Vanderstukken, Joke, Varga, John, Vassilopoulos, Dimitrios, Veale, Douglas J., Viatte, Sebastien, Vincent, Tonia, Vital, Edward M., von Loga, Isabell S., Wallace, Daniel J., Walsh, Nicola, Warber, Sara L., Warburton, Gary, Ward, Robert J., Watts, Laura, Watts, Richard A., Wedderburn, Lucy R., Weinblatt, Michael E., Weir, Matthew R., Sr., Weisman, Michael H., Weiss, Pamela F., Wenham, Claire Y.J., West, Sterling G., White, Harriet Branford, White, Kenneth E., Wilkinson, David J., Williams, David E., Williams, Richard, Wilson, Hannah, Winthrop, Kevin L., Witt, Claudia M., Witzmann, Gerhard, Wong, John B., Woolf, Anthony D., Wordsworth, Paul B., Worthington, Jane, Wysham, Katherine D., Xu, Huji, Young, David A., Young, Stephen P., Yusof, Md Yuzaiful Md, Zhuang, Haoyang, and Zink, Angela

Published
2019
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29. Epithelial-mesenchymal transition and nuclear β-catenin induced by conditional intestinal disruption of Cdh1 with Apc is E-cadherin EC1 domain dependent

Author

Matheson, Julia, primary, Bühnemann, Claudia, additional, Carter, Emma J., additional, Barnes, David, additional, Hoppe, Hans-Jürgen, additional, Hughes, Jennifer, additional, Cobbold, Stephen, additional, Harper, James, additional, Morreau, Hans, additional, Surakhy, Mirvat, additional, and Hassan, A. Bassim, additional

Published
2016
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32. Circulating levels of insulin-like growth factor-II/mannose-6-phosphate receptor in obesity and type 2 diabetes

Author

Jeyaratnaganthan, Nilani, Højlund, Kurt, Kroustrup, Jens Peter, Larsen, Jens Fromholt, Bjerre, Mette, Levin, Klavs, Beck-Nielsen, Henning, Frago, Susana, Hassan, A Bassim, Flyvbjerg, Allan, and Frystyk, Jan

Subjects
medicine.medical_specialty, Gastroplasty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Type 2 diabetes, Validation Studies as Topic, Receptor, IGF Type 2, Cohort Studies, Endocrinology, Thinness, Insulin-Like Growth Factor II, Weight loss, Diabetes mellitus, Internal medicine, Weight Loss, medicine, Extracellular, Humans, Nutritional Physiological Phenomena, Obesity, Receptor, business.industry, Insulin, Case-control study, medicine.disease, Diabetes Mellitus, Type 2, Case-Control Studies, medicine.symptom, business, Blood Chemical Analysis
Abstract

OBJECTIVE: The extracellular domain of the insulin-like growth factor II/mannose-6-phosphate receptor (IGF-II/M6P-R) is present in the circulation, but its relationship with plasma IGF-II is largely unknown. As IGF-II appears to be nutritionally regulated, we studied the impact of obesity, type 2 diabetes (T2D) and weight loss on circulating levels of IGF-II and its soluble receptor. METHODS: Twenty-three morbidly obese non-diabetic subjects were studied before and after gastric banding (GB), reducing their BMI from 59.3+/-1.8 to 52.7+/-1.6 kg/m(2). Lean controls (n=10, BMI 24.2+/-0.5 kg/m(2)), moderately obese controls (n=21, BMI 31.8+/-1.0 kg/m(2)) and obese T2D patients (n=20, BMI 32.3+/-0.8 kg/m(2)) were studied before and after a hyperinsulinaemic euglycaemic clamp. RESULTS: Morbidly obese subjects had elevated IGF-II/M6P-R and IGF-II levels, which both decreased following GB (IGF-II/M6P-R: from 0.97+/-0.038 to 0.87+/-0.030 nmol/l, P=0.001; IGF-II: from 134+/-7 to 125+/-6 nmol/l, P=0.01), as did fasting plasma glucose and insulin (P

Published
2010

34. Quantification of the Heterogeneity of Prognostic Cellular Biomarkers in Ewing Sarcoma Using Automated Image and Random Survival Forest Analysis

Author

Bühnemann, Claudia, primary, Li, Simon, additional, Yu, Haiyue, additional, Branford White, Harriet, additional, Schäfer, Karl L., additional, Llombart-Bosch, Antonio, additional, Machado, Isidro, additional, Picci, Piero, additional, Hogendoorn, Pancras C. W., additional, Athanasou, Nicholas A., additional, Noble, J. Alison, additional, and Hassan, A. Bassim, additional

Published
2014
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37. An open-label international multicentric phase II study of nilotinib in progressive pigmented villo-nodular synovitis (PVNS) not amenable to a conservative surgical treatment.

Author

Gelderblom, Hans, primary, Pérol, David, additional, Chevreau, Christine, additional, Tattersall, Martin HN, additional, Stacchiotti, Silvia, additional, Casali, Paolo Giovanni, additional, Cropet, Claire, additional, Piperno-Neumann, Sophie, additional, Le Cesne, Axel, additional, Italiano, Antoine, additional, Ferraresi, Virginia, additional, Duffaud, Florence, additional, Penel, Nicolas, additional, Dileo, Palma, additional, Bertucci, François, additional, Hassan, Andrew Bassim, additional, Kroep, Judith R., additional, Denizot-Guillemaut, Severine, additional, and Blay, Jean-Yves, additional

Published
2013
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40. An open-label international multicentric phase II study of nilotinib in progressive pigmented villo-nodular synovitis (PVNS) not amenable to a conservative surgical treatment.

Author

Ray-Coquard, Isabelle, primary, Gelderblom, Hans, additional, Chevreau, Christine, additional, Kroep, Judith R., additional, Italiano, Antoine, additional, Stacchiotti, Silvia, additional, Le Cesne, Axel, additional, Piperno-Neumann, Sophie, additional, Ferraresi, Virginia, additional, Duffaud, Florence, additional, Penel, Nicolas, additional, Cassier, Philippe A, additional, Tatersall, Martin, additional, Hassan, Andrew Bassim, additional, Bui Nguyen, Binh, additional, Bourne Branchu, Veronique, additional, Guillemaut, Severine, additional, Cropet, Claire, additional, Perol, David, additional, and Blay, Jean-Yves, additional

Published
2012
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43. Structure and functional analysis of the IGF-II/IGF2R interaction

Author

Brown, James, primary, Delaine, Carlie, additional, Zaccheo, Oliver J, additional, Siebold, Christian, additional, Gilbert, Robert J, additional, van Boxel, Gijs, additional, Denley, Adam, additional, Wallace, John C, additional, Hassan, A Bassim, additional, Forbes, Briony E, additional, and Jones, E Yvonne, additional

Published
2007
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