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5. 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus

Author

Aringer, Martin, Costenbader, Karen, Daikh, David, Brinks, Ralph, Mosca, Marta, Ramsey‐Goldman, Rosalind, Smolen, Josef S, Wofsy, David, Boumpas, Dimitrios T, Kamen, Diane L, Jayne, David, Cervera, Ricard, Costedoat‐Chalumeau, Nathalie, Diamond, Betty, Gladman, Dafna D, Hahn, Bevra, Hiepe, Falk, Jacobsen, Søren, Khanna, Dinesh, Lerstrøm, Kirsten, Massarotti, Elena, McCune, Joseph, Ruiz‐Irastorza, Guillermo, Sanchez‐Guerrero, Jorge, Schneider, Matthias, Urowitz, Murray, Bertsias, George, Hoyer, Bimba F, Leuchten, Nicolai, Tani, Chiara, Tedeschi, Sara K, Touma, Zahi, Schmajuk, Gabriela, Anic, Branimir, Assan, Florence, Chan, Tak Mao, Clarke, Ann Elaine, Crow, Mary K, Czirják, László, Doria, Andrea, Graninger, Winfried, Halda‐Kiss, Bernadett, Hasni, Sarfaraz, Izmirly, Peter M, Jung, Michelle, Kumánovics, Gábor, Mariette, Xavier, Padjen, Ivan, Pego‐Reigosa, José M, Romero‐Diaz, Juanita, Fernández, Íñigo Rúa‐Figueroa, Seror, Raphaèle, Stummvoll, Georg H, Tanaka, Yoshiya, Tektonidou, Maria G, Vasconcelos, Carlos, Vital, Edward M, Wallace, Daniel J, Yavuz, Sule, Meroni, Pier Luigi, Fritzler, Marvin J, Naden, Ray, Dörner, Thomas, and Johnson, Sindhu R

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lupus, Autoimmune Disease, Inflammatory and immune system, Adult, Antibodies, Antinuclear, Antibodies, Antiphospholipid, Autoantibodies, Cohort Studies, Complement System Proteins, Decision Support Techniques, Delphi Technique, Europe, Female, Humans, International Cooperation, Lupus Erythematosus, Systemic, Male, Middle Aged, Rheumatology, Sensitivity and Specificity, Societies, Medical, United States, Immunology, Public Health and Health Services, Arthritis & Rheumatology, Clinical sciences
Abstract

ObjectiveTo develop new classification criteria for systemic lupus erythematosus (SLE) jointly supported by the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR).MethodsThis international initiative had four phases. 1) Evaluation of antinuclear antibody (ANA) as an entry criterion through systematic review and meta-regression of the literature and criteria generation through an international Delphi exercise, an early patient cohort, and a patient survey. 2) Criteria reduction by Delphi and nominal group technique exercises. 3) Criteria definition and weighting based on criterion performance and on results of a multi-criteria decision analysis. 4) Refinement of weights and threshold scores in a new derivation cohort of 1,001 subjects and validation compared with previous criteria in a new validation cohort of 1,270 subjects.ResultsThe 2019 EULAR/ACR classification criteria for SLE include positive ANA at least once as obligatory entry criterion; followed by additive weighted criteria grouped in 7 clinical (constitutional, hematologic, neuropsychiatric, mucocutaneous, serosal, musculoskeletal, renal) and 3 immunologic (antiphospholipid antibodies, complement proteins, SLE-specific antibodies) domains, and weighted from 2 to 10. Patients accumulating ≥10 points are classified. In the validation cohort, the new criteria had a sensitivity of 96.1% and specificity of 93.4%, compared with 82.8% sensitivity and 93.4% specificity of the ACR 1997 and 96.7% sensitivity and 83.7% specificity of the Systemic Lupus International Collaborating Clinics 2012 criteria.ConclusionThese new classification criteria were developed using rigorous methodology with multidisciplinary and international input, and have excellent sensitivity and specificity. Use of ANA entry criterion, hierarchically clustered, and weighted criteria reflects current thinking about SLE and provides an improved foundation for SLE research.

Published
2019

6. Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus: the PISCOS study

Author

Appenzeller, Simone, Aranow, Cynthia, Askanase, Anca, Avcin, Tadej, Bae, Sang-Cheol, Bertsias, George, Bonfa, Eloisa, Cairoli, Ernesto, Cardiel, Mario H, Cervera, Ricard, Chasset, François, Chizzolini, Carlo, Clarke, Ann E, Conti, Fabrizio, Costedoat-Chalumeau, Nathalie, Czirják, László, Doria, Andrea, Dörner, Thomas, Espinosa, Gerard, Fischer-Betz, Rebecca, Garcìa, Mercedes, Gladman, Dafna D, González, Luis A, Gunnarsson, Iva, Hamijoyo, Laniyati, Hanly, John G, Hasni, Sarfaraz A, Houssiau, Frédéric A, Inanç, Murat, Inês, Luís S, Isenberg, David, Jacobsen, Soren, Jan Wu, Yeong-Jian, Kaneko, Yuko, Katsumata, Yasuhiro, Lau, Chak S, Legge, Alexandra C, Lerang, Karoline, Limper, Maarten, Louthrenoo, Worawit, Luo, Shue-Fen, Marinho, António, Massardo, Loreto, Mathian, Alexis, Mosca, Marta, Nikpour, Mandana, Pego-Reigosa, José M, Peschken, Christine A, Pons-Estel, Bernardo A, Pons-Estel, Guillermo J, Rahman, Anisur, Rednic, Simona, Ribi, Camillo, Ruiz-Irastorza, Guillermo, Sato, Emilia I, Saxena, Amit, Schneider, Matthias, Sebastiani, Gian Domenico, Strand, Vibeke, Svenungsson, Elisabet, Tanaka, Yoshiya, Tazi Mezalek, Zoubida, Tee, Michael L, Tincani, Angela, Touma, Zahi, Troldborg, Anne, Vasconcelos, Carlos, Vinet, Évelyne, Vital, Edward M, Voskuyl, Alexandre E, Voss, Anne, Wallace, Daniel, Ward, Michael, Zamora, Leonid D, Piga, Matteo, Chessa, Elisabetta, Morand, Eric F, Ugarte-Gil, Manuel F, Tektonidou, Maria, van Vollenhoven, Ronald, Petri, Michelle, and Arnaud, Laurent

Published
2022
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7. A Multiomic Analysis to Identify Drivers of Subclinical Vascular Disease in Systemic Lupus Erythematosus.

Author

Oliveira, Christopher, Temesgen‐Oyelakin, Yenealem, Naqi, Mohammad, Davis, Michael, Naz, Faiza, Dell'Orso, Stefania, Brooks, Stephen, Kuhn, Skyler, Hill, Tom, Li, Xiaobai, Patel, Nidhi, Parel, Philip, Gadina, Massimo, Gupta, Sarthak, Mehta, Nehal, Hasni, Sarfaraz A., and Kaplan, Mariana J.

Subjects
RISK assessment, PROTEINS, RESEARCH funding, RADIOPHARMACEUTICALS, MULTIOMICS, DEOXY sugars, SYSTEMIC lupus erythematosus, DESCRIPTIVE statistics, CARDIOVASCULAR disease diagnosis, PROTEOMICS, EMISSION-computed tomography, VASCULAR diseases, DISEASE progression, BIOMARKERS, SEQUENCE analysis, INTERLEUKINS, TUMOR necrosis factors, EVALUATION, DISEASE risk factors
Abstract

Objective: Systemic lupus erythematosus (SLE) increases cardiovascular disease (CVD) risk, and this is not explained by traditional risk factors. Characterization of blood immunologic signatures that associate with subclinical CVD and predict its progression has been challenging and may help identify subgroups at risk. Methods: Patients with SLE (n = 77) and healthy controls (HCs) (n = 27) underwent assessments of arterial stiffness, vascular wall inflammation, and coronary atherosclerosis burden with cardio‐ankle vascular index (CAVI); fluorodeoxyglucose–positron emission tomography/computed tomography (CT) (target‐to‐background ratio [TBR]); and coronary CT angiography. Whole blood bulk RNA sequencing was performed in a subset of study participants (HC n = 10, SLE n = 20). In a partially overlapping subset (HC n = 24, SLE n = 64), serum inflammatory protein biomarkers were quantified with an Olink platform. Results: CAVI, TBR, and noncalcified coronary plaque burden (NCB) were increased in patients with SLE compared to HCs. When comparing patients with SLE with high CAVI scores to those with low CAVI scores or to HCs, there was a down‐regulation of genes in pathways involved in the cell cycle and differentially regulated pathways related to metabolism. Distinct serum proteins associated with increased CAVI (CCL23, colony‐stimulating factor 1, latency‐activating peptide transforming growth factor β1, interleukin 33 [IL‐33], CD8A, and IL‐12B), NCB (monocyte chemotactic protein 4 and FMS‐like tyrosine kinase 3 ligand [Flt3L]), and TBR (CD5, IL‐1α, AXIN1, cystatin D [CST5], and tumor necrosis factor receptor superfamily 9; P < 0.05). Conclusion: Blood gene expression patterns and serum proteins that associate with worse vascular phenotypes suggest dysregulated immune and metabolic pathways linked to premature CVD. Cytokines and chemokines identified in associations with arterial stiffness, inflammation, and NCB in SLE may allow for characterization of new CVD biomarkers in lupus. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism

Author

Gupta, Sarthak, Nakabo, Shuichiro, Blanco, Luz P., O’Neil, Liam J., Wigerblad, Gustaf, Goel, Rishi R., Mistry, Pragnesh, Jiang, Kan, Carmona-Rivera, Carmelo, Chan, Diana W., Wang, Xinghao, Pedersen, Hege L., Gadkari, Manasi, Howe, Katherine N., Naz, Faiza, Dell’Orso, Stefania, Hasni, Sarfaraz A., Dempsey, Caeden, Buscetta, Ashley, Frischmeyer-Guerrerio, Pamela A., Kruszka, Paul, Muenke, Maximilian, Franco, Luis M., Sun, Hong-Wei, and Kaplan, Mariana J.

Published
2020

12. Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy.

Author

Blazkova, Jana, Gupta, Sarthak, Liu, Yudong, Gaudilliere, Brice, Ganio, Edward, Bolen, Christopher, Saar-Dover, Ron, Fragiadakis, Gabriela, Angst, Martin, Hasni, Sarfaraz, Aghaeepour, Nima, Stevenson, David, Baldwin, Nicole, Anguiano, Esperanza, Chaussabel, Damien, Altman, Matthew, Kaplan, Mariana, Davis, Mark, and Furman, David

Subjects
Adult, Age Factors, Aged, Aged, 80 and over, Blood Cells, Female, Granulocyte Precursor Cells, Humans, Male, Middle Aged, Neutrophils, Pregnancy, Sex, Transcriptome, Young Adult
Abstract

Despite clear differences in immune system responses and in the prevalence of autoimmune diseases between males and females, there is little understanding of the processes involved. In this study, we identified a gene signature of immature-like neutrophils, characterized by the overexpression of genes encoding for several granule-containing proteins, which was found at higher levels (up to 3-fold) in young (20-30 y old) but not older (60 to >89 y old) males compared with females. Functional and phenotypic characterization of peripheral blood neutrophils revealed more mature and responsive neutrophils in young females, which also exhibited an elevated capacity in neutrophil extracellular trap formation at baseline and upon microbial or sterile autoimmune stimuli. The expression levels of the immature-like neutrophil signature increased linearly with pregnancy, an immune state of increased susceptibility to certain infections. Using mass cytometry, we also find increased frequencies of immature forms of neutrophils in the blood of women during late pregnancy. Thus, our findings show novel sex differences in innate immunity and identify a common neutrophil signature in males and in pregnant women.

Published
2017

13. Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögren's disease.

Author

Gupta, Sarthak, Yamada, Eiko, Nakamura, Hiroyuki, Perez, Paola, Pranzatelli, Thomas J. F., Dominick, Kalie, Shyh-Ing Jang, Abed, Mehdi, Martin, Daniel, Burbelo, Peter, ChangYu Zheng, French, Ben, Alevizos, Ilias, Khavandgar, Zohreh, Beach, Margaret, Pelayo, Eileen, Walitt, Brian, Hasni, Sarfaraz, Kaplan, Mariana J., and Tandon, Mayank

Published
2024
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14. Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus

Author

Hasni, Sarfaraz A., Gupta, Sarthak, Davis, Michael, Poncio, Elaine, Temesgen-Oyelakin, Yenealem, Carlucci, Philip M., Wang, Xinghao, Naqi, Mohammad, Playford, Martin P., Goel, Rishi R., Li, Xiaobai, Biehl, Ann J., Ochoa-Navas, Isabel, Manna, Zerai, Shi, Yinghui, Thomas, Donald, Chen, Jinguo, Biancotto, Angélique, Apps, Richard, Cheung, Foo, Kotliarov, Yuri, Babyak, Ashley L., Zhou, Huizhi, Shi, Rongye, Stagliano, Katie, Tsai, Wanxia Li, Vian, Laura, Gazaniga, Nathalia, Giudice, Valentina, Lu, Shajia, Brooks, Stephen R., MacKay, Meggan, Gregersen, Peter, Mehta, Nehal N., Remaley, Alan T., Diamond, Betty, O’Shea, John J., Gadina, Massimo, and Kaplan, Mariana J.

Published
2021
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16. Contributors

Author

Agmon-Levin, Nancy, primary, Alarcón, Graciela S., additional, Amengual, Olga, additional, Ardoin, Stacy P., additional, Arora, Swati, additional, Atisha-Fregoso, Yemil, additional, Atkinson, John P., additional, Atsumi, Tatsuya, additional, Ayoub, Isabelle, additional, Barilla-LaBarca, Maria-Louise, additional, Bermas, Bonnie L., additional, Bernatsky, Sasha, additional, Bertsias, George, additional, Bichile, Tanmayee, additional, Blanco, Patrick, additional, Bohgaki, Miyuki, additional, Bonsmann, Gisela, additional, Borghi, Maria Orietta, additional, Boumpas, Dimitrios T., additional, Bourn, Rebecka, additional, Buyon, Jill P., additional, Caricchio, Roberto, additional, Chan, Edward K.L., additional, Chang, Christopher, additional, Charrier, Manon, additional, Chighizola, Cecilia Beatrice, additional, Clarke, Ann E., additional, Crispín, José C., additional, Cuneo, Bettina, additional, Dörner, Thomas, additional, Damato, Erika M., additional, Denniston, Alastair K.O., additional, Devlin, Amy, additional, Diamond, Betty, additional, Ernandez, T., additional, Falasinnu, Titilola, additional, Fernandez-Ruiz, Ruth, additional, Fitzpatrick, Brianna, additional, Forbess, Lindsy, additional, Frangou, Eleni A., additional, Fritzler, Marvin J., additional, Fu, Shu Man, additional, Furie, Richard, additional, Gaskin, Felicia, additional, Gladman, Dafna, additional, Gordon, Caroline, additional, Grammer, Amrie C., additional, Greidinger, Eric L., additional, Greiling, Teri M., additional, Han, Shuhong, additional, Hansen, James E., additional, Hasni, Sarfaraz A., additional, Hassan, Fadi, additional, Hedrich, Christian M., additional, Hiromura, Keiju, additional, Horowitz, Diane, additional, Huang, Xin, additional, Hunt, David, additional, Izmirly, Peter M., additional, James, Judith A., additional, Jarjour, Wael N., additional, Jefferies, Caroline A., additional, Jefferies, Caroline, additional, Jiang, Xiaoyue, additional, Kaplan, Mariana J., additional, Katsuyama, Takayuki, additional, Khamashta, Munther, additional, Kingsmore, Kathryn M., additional, Koike, Takao, additional, Kono, Dwight H., additional, Kriegel, Martin A., additional, Kuhn, Annegret, additional, Kyttaris, Vasileios C, additional, La Cava, Antonio, additional, Ladouceur, Alexandra, additional, Lahita, Robert G., additional, Landmann, Aysche, additional, Lazaro, Estibaliz, additional, Lennard Richard, Mara L., additional, Lino, Andreia C., additional, Lipsky, Peter E., additional, Liszewski, M. Kathryn, additional, Lo, Mindy S., additional, Lu, Qianjin, additional, Mahieu, Mary, additional, Malkiel, Susan, additional, Manzi, Susan, additional, Marder, Galina, additional, Mayadas, T.N., additional, Meroni, Pier Luigi, additional, Merrill, Joan T., additional, Mohan, Chandra, additional, Mok, Chi Chiu, additional, Moulton, Vaishali R., additional, Murray, Philip I., additional, Naffaa, Mohammad E., additional, Nangaku, Masaomi, additional, Niewold, Timothy, additional, Okubo, K., additional, Olsen, Nancy J., additional, Pal, Trina, additional, Paz, Ziv, additional, Perl, Andras, additional, Pons-Estel, Guillermo J., additional, Qu, Bo, additional, Rahman, Anisur, additional, Raman, Ziaur S.M., additional, Ramsey-Goldman, Rosalind, additional, Reeves, Westley H., additional, Richez, Christophe, additional, Rosetti, Florencia, additional, Rovin, Brad H., additional, Rubin, Robert L., additional, Saeli, Stephanie, additional, Saggu, G., additional, Sammaritano, Lisa R., additional, Satoh, Minoru, additional, Sawalha, Amr H., additional, Saxena, Amit, additional, Sciascia, Savino, additional, Shaharir, Syahrul Sazliyana, additional, Sharabi, Amir, additional, Shen, Nan, additional, Shmerling, Robert H., additional, Simard, Julia F., additional, Sisirak, Vanja, additional, Slight-Webb, Samantha, additional, Stillman, Isaac Ely, additional, Sung, Sun-Sang J., additional, Thakkar, Payal, additional, Theofilopoulos, Argyrios N., additional, Thomas, Jr, Donald E., additional, Tissera, Hiromi, additional, Touma, Zahi, additional, Tsao, Betty P., additional, Ugarte-Gil, Manuel F., additional, Urowitz, Murray B., additional, Vieira, Silvio Manfredo, additional, Wainwright, Benjamin, additional, Wallace, Daniel J., additional, Wang, Hongyang, additional, Wu, Haijing, additional, Yahia, Soad Haj, additional, Yu, C. Yung, additional, Zhao, Zhenhuan, additional, and Zhuang, Haoyang, additional

Published
2021
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20. Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögren's Disease

Author

Warner, Blake Matthew, primary, Gupta, Sarthak, additional, Yamada, Eiko, additional, Nakamura, Hiroyuki, additional, Perez, Paola, additional, Pranzatelli, Thomas J.F., additional, Dominick, Kalie, additional, Jang, Shyh-Ing, additional, Abed, Mehdi, additional, Martin, Dani, additional, Burbelo, Peter, additional, Zheng, Changyu, additional, French, Ben, additional, Alevizos, Ilias, additional, Khavandgar, Zohreh, additional, Beach, Margaret, additional, Pelayo, Eileen, additional, Walitt, Brian, additional, Hasni, Sarfaraz, additional, Kaplan, Mariana, additional, Tandon, Mayank, additional, Magone, M. Teresa, additional, Kleiner, David, additional, Chiorini, Jay, additional, and Baer, Alan, additional

Published
2023
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21. Successful Treatment of Paecilomyces variotii Pneumonia and Lupus Nephritis With Posaconazole-Cyclophosphamide Co-administration Without Drug Interaction–Induced Toxicity

Author

Pechacek, Joseph, primary, Webb, Taura, additional, Ferré, Elise M N, additional, Schmitt, Monica M, additional, DiMaggio, Thomas, additional, Kobrin, Dale, additional, Rajasimhan, Suraj, additional, Colton, Ben, additional, Lewis, Russell E, additional, Andes, David, additional, Herrera, Alejandro, additional, Hammoud, Dima, additional, Seyedmousavi, Seyedmojtaba, additional, Hasni, Sarfaraz, additional, Bolaños, Jonathan, additional, Afzali, Behdad, additional, and Lionakis, Michail S, additional

Published
2023
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23. Neuropsychiatric lupus in late- and early-onset systemic lupus erythematosus patients: a systematic review and meta-analysis.

Author

Pamuk, Omer Nuri, Raza, Ali Abbas, and Hasni, Sarfaraz

Subjects
SYSTEMIC lupus erythematosus diagnosis, ONLINE information services, MEDICAL databases, NEUROPSYCHOLOGY, META-analysis, CONFIDENCE intervals, PERIPHERAL neuropathy, NEUROLOGICAL disorders, SYSTEMATIC reviews, AGE distribution, PSYCHOSES, DELAYED onset of disease, NEUROBEHAVIORAL disorders, AGE factors in disease, DESCRIPTIVE statistics, AFFECTIVE disorders, RESEARCH funding, MEDLINE, ODDS ratio, SEIZURES (Medicine), PROBABILITY theory
Abstract

Objectives Late-onset SLE is usually milder and associated with lower frequency of LN and neuropsychiatric manifestations. The diagnosis of NPSLE is especially challenging in older patients because of increased incidence of neurological comorbidities. We performed a systematic review and meta-analysis to evaluate the differences in NPSLE manifestations in early-onset (<50-year-old) vs late-onset (≥50-year-old) SLE patients. Methods A literature search was performed using the PubMed, Web of Science and Cochrane Library databases. Studies available in English (1959–2022) including a late-onset SLE comparison group and evaluating the frequency of NPSLE were eligible. A forest plot was used to compare odds ratios (95% CI) of incidence and manifestations of NPSLE by age groups. Study heterogeneity was assessed using I 2 statistics. Results A total of 44 studies, including 17 865 early-onset and 2970 late-onset SLE patients, fulfilled our eligibility criteria. CNS involvement was reported in 3326 patients. Cumulative NPSLE frequency was higher in the early-onset group than in the late-onset group (OR: 1.41, 95% CI: 1.24, 1.59, P  < 0.0001). In early-onset SLE patients, seizures (OR: 1.68, 95% CI: 1.27, 2.22) and psychosis (OR: 1.72, 95% CI: 1.23, 2.41) were more common than in late-onset SLE patients (P values, 0.0003 and 0.0014, respectively). Peripheral neuropathy was more commonly reported in the late-onset SLE group than in the early-onset SLE group (OR: 0.64, 95% CI: 0.47, 0.86, P  = 0.004). Conclusion Our meta-analysis revealed that the frequencies of overall NPSLE, seizures, and psychosis were less common in late-onset SLE patients than in early-onset SLE patients. In contrast, peripheral neuropathy was more common in the late-onset SLE group. [ABSTRACT FROM AUTHOR]

Published
2024
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25. List of Contributors

Author

Abraham, Roshini Sarah, primary, Albanesi, Cristina, additional, Alevizos, Ilias, additional, Anguita, Juan, additional, Antiochos, Brendan, additional, Aranow, Cynthia, additional, Atkinson, John P., additional, Austin, Howard A., additional, Babu, Subash, additional, Ballow, Mark C., additional, Balow, James E., additional, Belmont, John W., additional, Berek, Claudia, additional, Beukelman, Timothy, additional, Bhavsar, Tapan, additional, Bird, J. Andrew, additional, Blutt, Sarah E., additional, Boguniewicz, Mark, additional, Bonamichi-Santos, Rafael, additional, Boisson, Bertrand, additional, Borzova, Elena, additional, Boyaka, Prosper N., additional, Boyce, Joshua, additional, Browne, Sarah K., additional, Burks, Wesley, additional, Bustamante, Jacinta, additional, Calder, Virginia L., additional, Campbell, Matthew, additional, Cardones, Adela Rambi G., additional, Casanova, Jean-Laurent, additional, Castells, Mariana, additional, Cavacini, Lisa A., additional, Chan, Edwin S.L., additional, Chaplin, David D., additional, Chatham, W. Winn, additional, Chen, Edward S., additional, Chinen, Javier, additional, Christopher-Stine, Lisa, additional, Ciancanelli, Michael, additional, Cope, Andrew P., additional, Corry, David B., additional, Crea, Filippo, additional, Cron, Randy Q., additional, Cuellar-Rodriguez, Jennifer M., additional, Dalakas, Marinos C., additional, Dann, Sara M., additional, Diamond, Betty, additional, Du, Terry W., additional, Dupuis-Boisson, Stéphanie, additional, Eagar, Todd N., additional, Elmets, Craig A., additional, Erkan, Doruk, additional, Fanning, Laura, additional, Fikrig, Erol, additional, Flego, Davide, additional, Fleisher, Thomas A., additional, Fonacier, Luz, additional, Fontenot, Andrew P., additional, Freeman, Alexandra F., additional, Frew, Anthony J., additional, Fujihashi, Kohtaro, additional, Gadina, Massimo, additional, Gatt, Moshe E., additional, Gershwin, M. Eric, additional, Gillespie, Susan L., additional, Goronzy, Jörg J., additional, Goswami, Sangeeta, additional, Grattan, Clive E.H., additional, Greenspan, Neil S., additional, Gupta, Sarthak, additional, Gustafson, Claire E., additional, Hall, Russell P., additional, Hamilton, Robert G., additional, Harrington, Laurie E., additional, Harrison, Leonard C., additional, Hasni, Sarfaraz A., additional, Helbling, Arthur, additional, Hester, Joanna, additional, Holland, Steven M., additional, Hourcade, Dennis, additional, Huntington, Nicholas D., additional, Hwangpo, Tracy, additional, Imboden, John B., additional, Issa, Fadi, additional, Izraeli, Shai, additional, Jaffe, Elaine S., additional, Jalkanen, Sirpa, additional, Jones, Stacie, additional, Jouanguy, Emmanuelle, additional, Kabbani, Sarah, additional, Kaufmann, Stefan H.E., additional, Kheradmand, Farrah, additional, Kohn, Donald B., additional, Korngold, Robert, additional, Kovalszki, Anna, additional, Kuhns, Douglas B., additional, Kulkarni, Hrishikesh, additional, Kuo, Caroline Y., additional, Lahouti, Arash, additional, Landgren, C. Ola, additional, Laurence, Arian, additional, Lee, Joyce S., additional, Lemière, Catherine, additional, Leung, Donald Y.M., additional, Levinson, Arnold I., additional, Levy, Ofer, additional, Lewis, Dorothy E., additional, Lin, Phoebe, additional, Linkermann, Andreas, additional, Liuzzo, Giovanna, additional, Lockshin, Michael D., additional, Lord, Allison K., additional, Lozier, Jay N., additional, Luong, Amber, additional, Luqmani, Raashid, additional, Mackay, Meggan, additional, Maltzman, Jonathan S., additional, Mannon, Peter J., additional, Manns, Michael P., additional, Martin, James G., additional, Maynard, Craig L., additional, McCash, Samual, additional, McDonald, Douglas R., additional, Melby, Peter C., additional, Miller, Stephen D., additional, Mitchell, Anna L., additional, Mohd-Zaki, Amirah, additional, Mold, Carolyn, additional, Moller, David R., additional, Monos, Dimitrios S., additional, Mueller, Scott N., additional, Mulders-Manders, Catharina M., additional, Mulligan, Mark J., additional, Müller, Ulrich R., additional, Munshi, Pashna N., additional, Murata, Kazunori, additional, Murphy, Philip M., additional, Navasa, Nicolás, additional, Noel, Pierre, additional, Notarangelo, Luigi D., additional, Nussbaum, Robert L., additional, Nutman, Thomas B., additional, Nutt, Stephen L., additional, Oliveira, João B., additional, Ortel, Thomas L., additional, O'Shea, John J., additional, Pai, Sung-Yun, additional, Pandit, Lavannya, additional, Paul, Mary E., additional, Pearce, Simon H.S., additional, Pedicino, Daniela, additional, Peterson, Erik J., additional, Picard, Capucine, additional, Pittaluga, Stefania, additional, Priel, Debra Long, additional, Puck, Jennifer, additional, Puel, Anne, additional, Radbruch, Andreas, additional, Reece, Stephen T., additional, Reveille, John D., additional, Rich, Robert R., additional, Roifman, Chaim M., additional, Rosen, Antony, additional, Rosenbaum, James T., additional, Rosenzweig, Sergio D., additional, Rouse, Barry T., additional, Rowley, Scott D., additional, Sakaguchi, Shimon, additional, Salmi, Marko, additional, Sant, Andrea J., additional, Satola, Sarah W., additional, Saw, Valerie, additional, Schechter, Marcos C., additional, Schroeder, Harry W., additional, Segal, Benjamin M., additional, Selmi, Carlo, additional, Shankar, Sushma, additional, Sharma, Anu, additional, Sharma, Padmanee, additional, Shearer, William T., additional, Siegel, Richard M., additional, Simon, Anna, additional, Smith, Gideon P., additional, Stephens, David S., additional, Stephens, Robin, additional, Straumann, Alex, additional, Teos, Leyla Y., additional, Timares, Laura, additional, Tonnus, Wulf, additional, Torres, Raul M., additional, Uzel, Gülbü, additional, van der Hilst, Jeroen C.H., additional, van der Meer, Jos W.M., additional, Varga, John, additional, Vyas, Jatin M., additional, Waldman, Meryl, additional, Weiser, Peter, additional, Weller, Peter F., additional, Weyand, Cornelia M., additional, Wigley, Fredrick M., additional, Winchester, Robert J., additional, Wing, James B., additional, Wood, Kathryn J., additional, Wu, Xiaobo, additional, Xu, Hui, additional, Yee, Cassian, additional, and Zhang, Shen-Ying, additional

Published
2019
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31. Changes in cardiorespiratory function and fatigue following 12 weeks of exercise training in women with systemic lupus erythematosus: a pilot study

Author

Hasni, Sarfaraz, primary, Feng, Li Rebekah, additional, Chapman, Marquis, additional, Gupta, Sarthak, additional, Ahmad, Anam, additional, Munday, Adam, additional, Mazhar, Mir Ali, additional, Li, Xiaobai, additional, Lu, Shajia, additional, Tsai, Wanxia Li, additional, Gadina, Massimo, additional, Davis, Michael, additional, Chu, Jun, additional, Manna, Zerai, additional, Nakabo, Shuichiro, additional, Kaplan, Mariana J, additional, Saligan, Leorey, additional, Keyser, Randall, additional, Chan, Leighton, additional, and Chin, Lisa M K, additional

Published
2022
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36. Peroxisome proliferator activated receptor-γ agonist pioglitazone improves vascular and metabolic dysfunction in systemic lupus erythematosus

Author

Hasni, Sarfaraz, primary, Temesgen-Oyelakin, Yenealem, additional, Davis, Michael, additional, Chu, Jun, additional, Poncio, Elaine, additional, Naqi, Mohammad, additional, Gupta, Sarthak, additional, Wang, Xinghao, additional, Oliveira, Christopher, additional, Claybaugh, Dillon, additional, Dey, Amit, additional, Lu, Shajia, additional, Carlucci, Philip, additional, Purmalek, Monica, additional, Manna, Zerai G, additional, Shi, Yinghui, additional, Ochoa-Navas, Isabel, additional, Chen, Jinguo, additional, Mukherjee, Amrita, additional, Han, Kyu Lee, additional, Cheung, Foo, additional, Koroleva, Galina, additional, Belkaid, Yasmine, additional, Tsang, John S, additional, Apps, Richard, additional, Thomas, Donald E, additional, Heller, Theo, additional, Gadina, Massimo, additional, Playford, Martin P, additional, Li, Xiaobai, additional, Mehta, Nehal N, additional, and Kaplan, Mariana J, additional

Published
2022
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38. Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus: the PISCOS study

Author

Piga, Matteo, primary, Chessa, Elisabetta, additional, Morand, Eric F, additional, Ugarte-Gil, Manuel F, additional, Tektonidou, Maria, additional, van Vollenhoven, Ronald, additional, Petri, Michelle, additional, Arnaud, Laurent, additional, Appenzeller, Simone, additional, Aranow, Cynthia, additional, Askanase, Anca, additional, Avcin, Tadej, additional, Bae, Sang-Cheol, additional, Bertsias, George, additional, Bonfa, Eloisa, additional, Cairoli, Ernesto, additional, Cardiel, Mario H, additional, Cervera, Ricard, additional, Chasset, François, additional, Chizzolini, Carlo, additional, Clarke, Ann E, additional, Conti, Fabrizio, additional, Costedoat-Chalumeau, Nathalie, additional, Czirják, László, additional, Doria, Andrea, additional, Dörner, Thomas, additional, Espinosa, Gerard, additional, Fischer-Betz, Rebecca, additional, Garcìa, Mercedes, additional, Gladman, Dafna D, additional, González, Luis A, additional, Gunnarsson, Iva, additional, Hamijoyo, Laniyati, additional, Hanly, John G, additional, Hasni, Sarfaraz A, additional, Houssiau, Frédéric A, additional, Inanç, Murat, additional, Inês, Luís S, additional, Isenberg, David, additional, Jacobsen, Soren, additional, Jan Wu, Yeong-Jian, additional, Kaneko, Yuko, additional, Katsumata, Yasuhiro, additional, Lau, Chak S, additional, Legge, Alexandra C, additional, Lerang, Karoline, additional, Limper, Maarten, additional, Louthrenoo, Worawit, additional, Luo, Shue-Fen, additional, Marinho, António, additional, Massardo, Loreto, additional, Mathian, Alexis, additional, Mosca, Marta, additional, Nikpour, Mandana, additional, Pego-Reigosa, José M, additional, Peschken, Christine A, additional, Pons-Estel, Bernardo A, additional, Pons-Estel, Guillermo J, additional, Rahman, Anisur, additional, Rednic, Simona, additional, Ribi, Camillo, additional, Ruiz-Irastorza, Guillermo, additional, Sato, Emilia I, additional, Saxena, Amit, additional, Schneider, Matthias, additional, Sebastiani, Gian Domenico, additional, Strand, Vibeke, additional, Svenungsson, Elisabet, additional, Tanaka, Yoshiya, additional, Tazi Mezalek, Zoubida, additional, Tee, Michael L, additional, Tincani, Angela, additional, Touma, Zahi, additional, Troldborg, Anne, additional, Vasconcelos, Carlos, additional, Vinet, Évelyne, additional, Vital, Edward M, additional, Voskuyl, Alexandre E, additional, Voss, Anne, additional, Wallace, Daniel, additional, Ward, Michael, additional, and Zamora, Leonid D, additional

Published
2022
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39. Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus:the PISCOS study

Author

Piga, Matteo, Chessa, Elisabetta, Morand, Eric F., Ugarte-Gil, Manuel F., Tektonidou, Maria, van Vollenhoven, Ronald, Petri, Michelle, Arnaud, Laurent, Appenzeller, Simone, Aranow, Cynthia, Askanase, Anca, Avcin, Tadej, Bae, Sang Cheol, Bertsias, George, Bonfa, Eloisa, Cairoli, Ernesto, Cardiel, Mario H., Cervera, Ricard, Chasset, François, Chizzolini, Carlo, Clarke, Ann E., Conti, Fabrizio, Costedoat-Chalumeau, Nathalie, Czirják, László, Doria, Andrea, Dörner, Thomas, Espinosa, Gerard, Fischer-Betz, Rebecca, Garcìa, Mercedes, Gladman, Dafna D., González, Luis A., Gunnarsson, Iva, Hamijoyo, Laniyati, Hanly, John G., Hasni, Sarfaraz A., Houssiau, Frédéric A., Inanç, Murat, Inês, Luís S., Isenberg, David, Jacobsen, Soren, Jan Wu, Yeong Jian, Kaneko, Yuko, Katsumata, Yasuhiro, Lau, Chak S., Legge, Alexandra C., Lerang, Karoline, Limper, Maarten, Louthrenoo, Worawit, Luo, Shue Fen, Marinho, António, Piga, Matteo, Chessa, Elisabetta, Morand, Eric F., Ugarte-Gil, Manuel F., Tektonidou, Maria, van Vollenhoven, Ronald, Petri, Michelle, Arnaud, Laurent, Appenzeller, Simone, Aranow, Cynthia, Askanase, Anca, Avcin, Tadej, Bae, Sang Cheol, Bertsias, George, Bonfa, Eloisa, Cairoli, Ernesto, Cardiel, Mario H., Cervera, Ricard, Chasset, François, Chizzolini, Carlo, Clarke, Ann E., Conti, Fabrizio, Costedoat-Chalumeau, Nathalie, Czirják, László, Doria, Andrea, Dörner, Thomas, Espinosa, Gerard, Fischer-Betz, Rebecca, Garcìa, Mercedes, Gladman, Dafna D., González, Luis A., Gunnarsson, Iva, Hamijoyo, Laniyati, Hanly, John G., Hasni, Sarfaraz A., Houssiau, Frédéric A., Inanç, Murat, Inês, Luís S., Isenberg, David, Jacobsen, Soren, Jan Wu, Yeong Jian, Kaneko, Yuko, Katsumata, Yasuhiro, Lau, Chak S., Legge, Alexandra C., Lerang, Karoline, Limper, Maarten, Louthrenoo, Worawit, Luo, Shue Fen, and Marinho, António

Abstract

The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence-based and expert-based consensus standardisation of the Physician Global Assessment (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). An international panel of 79 SLE experts participated in a three-round Delphi consensus process, in which 41 statements related to the PGA in SLE were rated, using a 0 (strongly disagree) to 10 (strongly agree) numerical rating scale. Statements with agreement of 75% or greater were selected and further validated by the expert panel. Consensus was reached on 27 statements, grouped in 14 recommendations, for the use of the PGA in SLE, design of the PGA scale, practical considerations for PGA scoring, and the relationship between PGA values and levels of disease activity. Among these recommendations, the expert panel agreed that the PGA should consist of a 0–3 visual analogue scale for measuring disease activity in patients with SLE in the preceding month. The PGA is intended to rate the overall disease activity, taking into account the severity of active manifestations and clinical laboratory results, but excluding organ damage, serology, and subjective findings unrelated to disease activity. The PGA scale ranges from “no disease activity” (0) to the “most severe disease activity” (3) and incorporates the values 1 and 2 as inner markers to categorise disease activity as mild (≥0·5 to 1), moderate (>1 and ≤2) and severe (>2 to 3). Only experienced physicians can rate the PGA, and it should be preferably scored by the same rater at each visit. The PISCOS results will allow for increased homogeneity and reliability of PGA ratings in routine clinical practice, definitions of remission and low disease activity, and future SLE trials.

Published
2022

40. Brief Report: Deficiency of Complement 1r Subcomponent in Early‐Onset Systemic Lupus Erythematosus: The Role of Disease‐Modifying Alleles in a Monogenic Disease

Author

Demirkaya, Erkan, Zhou, Qing, Smith, Carolyne K., Ombrello, Michael J., Deuitch, Natalie, Tsai, Wanxia L., Hoffmann, Patrycja, Remmers, Elaine F., Takeuchi, Masaki, Park, Yong Hwan, Chae, JaeJin, Barut, Kenan, Simsek, Dogan, Adrovic, Amra, Sahin, Sezgin, Caliskan, Salim, Chandrasekharappa, Settara C., Hasni, Sarfaraz A., Ombrello, Amanda K., Gadina, Massimo, Kastner, Daniel L., Kaplan, Mariana J., Kasapcopur, Ozgur, and Aksentijevich, Ivona

Published
2017
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42. List of Contributors

Author

Agmon-Levin, Nancy, primary, Alarcón, Graciela S., additional, Amengual, Olga, additional, Ardoin, Stacy P., additional, Atkinson, John P., additional, Atsumi, Tatsuya, additional, Ayoub, Isabelle, additional, Bermas, Bonnie L., additional, Bernatsky, Sasha, additional, Bertsias, George, additional, Blanco, Patrick, additional, Bohgaki, Miyuki, additional, Bonsmann, Gisela, additional, Borghi, Maria Orietta, additional, Boumpas, Dimitrios T., additional, Bourn, Rebecka, additional, Buyon, Jill P., additional, Caricchio, Roberto, additional, Catalina, Michelle D., additional, Chan, Edward K.L., additional, Chang, Christopher, additional, Chartrand, Sandra, additional, Chighizola, Cecilia Beatrice, additional, Clarke, Ann E., additional, Crispín, José C., additional, Dai, Chao, additional, Damato, Erika M., additional, Deng, Yun, additional, Denniston, Alastair K.O., additional, Devlin, Amy, additional, Diamond, Betty, additional, Dooley, Mary Anne, additional, Drijvers, Jefte M., additional, du Bois, Roland M., additional, Du, Yong, additional, Ernandez, T., additional, Ferretti, Concetta, additional, Fischer, Aryeh, additional, Fisher, Samantha, additional, Frangou, Eleni A., additional, Fritzler, Marvin J., additional, Furie, Richard, additional, Fu, Shu Man, additional, Gaskin, Felicia, additional, Gilkeson, Gary S., additional, Gladman, Dafna, additional, Goldman, Rosalind Ramsey, additional, González-Naranjo, Luis A., additional, Gordon, Caroline, additional, Grammer, Amrie C., additional, Greidinger, Eric L., additional, Hagberg, Niklas, additional, Hanly, John G., additional, Hansen, James E., additional, Han, Shuhong, additional, Hasni, Sarfaraz A., additional, Hedrich, Christian M., additional, Horowitz, Diane, additional, Huang, Xin, additional, Izmirly, Peter M., additional, Jacquemin, Clément, additional, James, Judith, additional, Jarjour, Wael N., additional, Kaplan, Mariana J., additional, Khamashta, Munther, additional, Koike, Takao, additional, Kono, Dwight H., additional, Konya, Christine, additional, Kuhn, Annegret, additional, Kyttaris, Vasileios C., additional, La Cava, Antonio, additional, Lahita, Robert G., additional, Landmann, Aysche, additional, Lipsky, Peter E., additional, Lo, Mindy S., additional, Lu, Qianjin, additional, Mahieu, Mary, additional, Malkiel, Susan, additional, Manzi, Susan, additional, Marder, Galina, additional, Mayadas, T.N., additional, Means, Terry K., additional, Meroni, Pier Luigi, additional, Merrill, Joan T., additional, Mohan, Chandra, additional, Mok, Chi Chiu, additional, Moulton, Vaishali R., additional, Murray, Philip I., additional, Oates, Jim C., additional, Paz, Ziv, additional, Pendergraft, William F., additional, Perl, Andras, additional, Pillai, Shiv, additional, Pons-Estel, Guillermo J., additional, Qu, Bo, additional, Rahman, Anisur, additional, Ramsey-Goldman, Rosalind, additional, Reeves, Westley H., additional, Rodríguez-Rodríguez, Noé, additional, Rönnblom, Lars, additional, Rosetti, Florencia, additional, Rovin, Brad H., additional, Ryals, Matthew M., additional, Saggu, G., additional, Sammaritano, Lisa R., additional, Satoh, Minoru, additional, Sawalha, Amr H., additional, Saxena, Amit, additional, Sciascia, Savino, additional, Shaharir, Syahrul, additional, Shao, Chengqun, additional, Shen, Nan, additional, Shmerling, Robert, additional, Shoenfeld, Yehuda, additional, Shumyak, Stepan, additional, Slight-Webb, Samantha, additional, Stillman, Isaac Ely, additional, Stojan, George, additional, Sung, Sun-Sang J., additional, Theofilopoulos, Argyrios N., additional, Thomas Jr., Donald E., additional, Tissera, Hiromi, additional, Touma, Zahi, additional, Tsao, Betty P., additional, Ugarte-Gil, Manuel F., additional, Urowitz, Murray B., additional, Volpe, Bruce T., additional, Wang, Hongyang, additional, Wener, Mark H., additional, Wu, Haijing, additional, Xu, Yuan, additional, Yang, Lijun, additional, Yu, C. Yung, additional, and Zhuang, Haoyang, additional

Published
2016
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44. Transmission disequilibrium analysis of whole genome data in childhood-onset systemic lupus erythematosus

Author

Vazzana, Kathleen M., Musolf, Anthony M., Bailey-Wilson, Joan E., Hiraki, Linda T., Silverman, Earl D., Scott, Christiaan, Dalgard, Clifton L., Hasni, Sarfaraz, Deng, Zuoming, Kaplan, Mariana J., and Lewandowski, Laura B.

Abstract

Childhood-onset systemic lupus erythematosus (cSLE) patients are unique, with hallmarks of Mendelian disorders (early-onset and severe disease) and thus are an ideal population for genetic investigation of SLE. In this study, we use the transmission disequilibrium test (TDT), a family-based genetic association analysis that employs robust methodology, to analyze whole genome sequencing data. We aim to identify novel genetic associations in an ancestrally diverse, international cSLE cohort. Forty-two cSLE patients and 84 unaffected parents from 3 countries underwent whole genome sequencing. First, we performed TDT with single nucleotide variant (SNV)-based (common variants) using PLINK 1.9, and gene-based (rare variants) analyses using Efficient and Parallelizable Association Container Toolbox (EPACTS) and rare variant TDT (rvTDT), which applies multiple gene-based burden tests adapted for TDT, including the burden of rare variants test. Applying the GWAS standard threshold (5.0 × 10−8) to common variants, our SNV-based analysis did not return any genome-wide significant SNVs. The rare variant gene-based TDT analysis identified many novel genes significantly enriched in cSLE patients, including HNRNPUL2, a DNA repair protein, and DNAH11, a ciliary movement protein, among others. Our approach identifies several novel SLE susceptibility genes in an ancestrally diverse childhood-onset lupus cohort.

Published
2023
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45. Multi-Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis

Author

Smith, Michael A., primary, Sinibaldi, Dominic, additional, Rahman, Saifur, additional, Chiang, Chia-Chien, additional, Hansen, Anna M., additional, Henault, Jill, additional, Roca, Carlos P., additional, Wang, Shu, additional, Zerrouki, Kamelia, additional, Filippi, Rebecca, additional, Groves, Christopher, additional, Manna, Zerai, additional, Chu, Jun, additional, Davis, Michael, additional, Gupta, Sarthak, additional, Morehouse, Christopher, additional, de los Reyes, Melissa, additional, Ettinger, Rachel, additional, Kolbeck, Roland, additional, Kaplan, Mariana J., additional, Sanjuan, Miguel A., additional, Siegel, Richard M., additional, Hasni, Sarfaraz, additional, and Casey, Kerry A., additional

Published
2022
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47. Long-term follow-up after lymphodepleting autologous haematopoietic cell transplantation for treatment-resistant systemic lupus erythematosus

Author

Goklemez, Sencer, primary, Hasni, Sarfaraz, additional, Hakim, Frances T, additional, Muraro, Paolo A, additional, Pirsl, Filip, additional, Rose, Jeremy, additional, Memon, Sarfraz, additional, Fowler, Daniel F, additional, Steinberg, Seth M, additional, Baker, Eva H, additional, Panch, Sandya R, additional, Gress, Ronald, additional, Illei, Gabor G, additional, Lipsky, Peter E, additional, and Pavletic, Steven Z, additional

Published
2021
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