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377 results on '"Hasegawa, Toshimichi"'

1. Exosomal miR-493 suppresses MAD2L1 and induces chemoresistance to intraperitoneal paclitaxel therapy in gastric cancer patients with peritoneal metastasis

Author

Makinoya, Masahiro, Miyatani, Kozo, Matsumi, Yoshiaki, Sakano, Yu, Shimizu, Shota, Shishido, Yuji, Hanaki, Takehiko, Kihara, Kyoichi, Matsunaga, Tomoyuki, Yamamoto, Manabu, Tokuyasu, Naruo, Takano, Shuichi, Sakamoto, Teruhisa, Hasegawa, Toshimichi, Saito, Hiroaki, Nakayama, Yuji, Osaki, Mitsuhiko, Okada, Futoshi, and Fujiwara, Yoshiyuki

Published
2024
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4. A low cumulative perioperative prognostic nutritional index predicts poor long-term outcomes in patients with gastric cancer: A single-center retrospective study in Japan

Author

Miyatani, Kozo, Sakano, Yu, Makinoya, Masahiro, Miyauchi, Wataru, Shimizu, Shota, Shishido, Yuji, Hanaki, Takehiko, Kihara, Kyoichi, Matsunaga, Tomoyuki, Yamamoto, Manabu, Tokuyasu, Naruo, Takano, Shuichi, Sakamoto, Teruhisa, Hasegawa, Toshimichi, Saito, Hiroaki, and Fujiwara, Yoshiyuki

Published
2023
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7. Circular stapling anastomosis with indocyanine green fluorescence imaging for cervical esophagogastric anastomosis after thoracoscopic esophagectomy: a propensity score-matched analysis

Author

Shishido, Yuji, Matsunaga, Tomoyuki, Makinoya, Masahiro, Miyauchi, Wataru, Shimizu, Shota, Miyatani, Kozo, Uejima, Chihiro, Morimoto, Masaki, Murakami, Yuki, Hanaki, Takehiko, Kihara, Kyoichi, Yamamoto, Manabu, Tokuyasu, Naruo, Takano, Shuichi, Sakamoto, Teruhisa, Saito, Hiroaki, Hasegawa, Toshimichi, and Fujiwara, Yoshiyuki

Published
2022
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11. Skeletal Muscle Mass Before Second-line Chemotherapy Correlates With Subsequent Prognosis and Rate of Late-line Chemotherapy in Patients With Unresectable Gastric Cancer

Author

MATSUNAGA, TOMOYUKI, primary, SATIO, HIROAKI, additional, SAKANO, YU, additional, MAKINOYA, MASAHIRO, additional, SHIMIZU, SHOTA, additional, SHISHIDO, YUJI, additional, MIYATANI, KOZO, additional, KONO, YUSUKE, additional, MURAKAMI, YUKI, additional, HANAKI, TAKEHIKO, additional, KIHARA, KYOICHI, additional, YAMAMOTO, MANABU, additional, TOKUYASU, NARUO, additional, TAKANO, SHUICHI, additional, SAKAMOTO, TERUHISA, additional, HASEGAWA, TOSHIMICHI, additional, and FUJIWARA, YOSHIYUKI, additional

Published
2023
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15. Hepatectomy for massive hepatic necrosis after transcatheter arterial embolization hemostasis for hepatic hemorrhage following hepatic trauma: A case report

Author

Hanaki, Takehiko, primary, Tokuyasu, Naruo, additional, Yata, Shinsaku, additional, Kishino, Mikiya, additional, Murakami, Yuki, additional, Shishido, Yuji, additional, Miyatani, Kozo, additional, Kihara, Kyoichi, additional, Matsunaga, Tomoyuki, additional, Yamamoto, Manabu, additional, Sakamoto, Teruhisa, additional, Hasegawa, Toshimichi, additional, and Fujiwara, Yoshiyuki, additional

Published
2023
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16. Preoperative low skeletal muscle volume can result in insufficient administration of S-1 adjuvant chemotherapy in older patients with stage II/III gastric cancer

Author

Kono, Yusuke, primary, Matsunaga, Tomoyuki, additional, Makinoya, Masahiro, additional, Shimizu, Shota, additional, Shishido, Yuji, additional, Miyatani, Kozo, additional, Kihara, Kyoichi, additional, Yamamoto, Manabu, additional, Takano, Shuichi, additional, Tokuyasu, Naruo, additional, Sakamoto, Teruhisa, additional, Hasegawa, Toshimichi, additional, and Fujiwara, Yoshiyuki, additional

Published
2023
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17. Prognostic significance of the cachexia index in patients with unresectable advanced gastric cancer receiving palliative chemotherapy: a retrospective single-center study

Author

Matsunaga, Tomoyuki, primary, Satio, Hiroaki, additional, Sakano, Yu, additional, Makinoya, Masahiro, additional, Shimizu, Shota, additional, Shishido, Yuji, additional, Miyatani, Kozo, additional, Hanaki, Takehiko, additional, Kihara, Kyoichi, additional, Yamamoto, Manabu, additional, Tokuyasu, Naruo, additional, Takano, Shuichi, additional, Sakamoto, Teruhisa, additional, Hasegawa, Toshimichi, additional, and Fujiwara, Yoshiyuki, additional

Published
2023
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18. Usefulness of the Modified Frailty Index for Predicting Pneumonia Occurrence After Esophagectomy

Author

Miyauchi, Wataru, Matsunaga, Tomoyuki, Sakano, Yu, Makinoya, Masahiro, Shimizu, Shota, Shishido, Yuji, Miyatani, Kozo, Sakamoto, Teruhisa, Hasegawa, Toshimichi, and Fujiwara, Yoshiyuki

Subjects
modified frailty index, esophagectomy, Original Article, frailty, General Medicine
Abstract

Background: Esophagectomy is an invasive and complication-prone surgical procedure. Therefore, a tool that can predict the occurrence of postoperative complications may be useful for perioperative management. In this study, we investigated whether the modified frailty index (mFI) could be a useful tool for predicting the postoperative complications of esophagectomy. Methods: In this study, 162 patients who underwent curative esophagectomy for esophageal squamous cell carcinoma from 2004 to 2019 at our institution were included. The patients were divided into the high mFI (≥ 0.27) and low mFI (< 0.27) groups, and the short-term postoperative outcomes of each group were examined retrospectively. Results: Regarding background factors, age and the American Society of Anesthesiologists physical status classification were significantly higher in the high mFI group (P = 0.049 and P = 0.002, respectively); however, the other items were not significantly different between the two groups. Regarding surgical outcomes, no significant differences in operative time, blood loss, and hospital stay were observed between the two groups. Regarding postoperative complications, pneumonia was significantly more common in the high mFI group (P = 0.035). In multivariate analysis, high mFI (P = 0.034) was an independent predictor of pneumonia, along with operative time ≥ 613 min (P = 0.03) and preoperative BMI < 20.48 (P = 0.006). Conclusion: The mFI is useful for predicting pneumonia after esophagectomy.

Published
2023

19. Preoperative Osteopenia Is a Risk Factor for Death in Patients Undergoing Gastrectomy for Gastric Cancer

Author

SHIMIZU, SHOTA, primary, MATSUNAGA, TOMOYUKI, additional, SAWATA, SHOHEI, additional, SAKANO, YU, additional, MAKINOYA, MASAHIRO, additional, SHISHIDO, YUJI, additional, MIYATANI, KOZO, additional, KONO, YUSUKE, additional, MURAKAMI, YUKI, additional, HANAKI, TAKEHIKO, additional, KIHARA, KYOICHI, additional, YAMAMOTO, MANABU, additional, TOKUYASU, NARUO, additional, TAKANO, SHUICHI, additional, SAKAMOTO, TERUHISA, additional, HASEGAWA, TOSHIMICHI, additional, and FUJIWARA, YOSHIYUKI, additional

Published
2023
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20. Successful treatment of peritoneal recurrence after gastric cancer surgery with intravenous and intraperitoneal paclitaxel combined with S-1 chemotherapy: a case report

Author

Miyatani, Kozo, Miyauchi, Wataru, Kono, Yusuke, Shishido, Yuji, Watanabe, Joji, Hanaki, Takehiko, Kihara, Kyoichi, Matsunaga, Tomoyuki, Yamamoto, Manabu, Fukumoto, Yoji, Tokuyasu, Naruo, Takano, Shuichi, Sakamoto, Teruhisa, Honjo, Soichiro, Hasegawa, Toshimichi, and Fujiwara, Yoshiyuki

Published
2020
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21. A gastroduodenal artery that branched from the celiac artery in gastrectomy: A rare case of an anatomical variant.

Author

Shimizu, Shota, Matsunaga, Tomoyuki, Sakano, Yu, Makinoya, Masahiro, Shishido, Yuji, Miyatani, Kozo, Kono, Yusuke, Murakami, Yuki, Hanaki, Takehiko, Kihara, Kyoichi, Yamamoto, Manabu, Tokuyasu, Naruo, Takano, Shuichi, Sakamoto, Teruhisa, Hasegawa, Toshimichi, and Fujiwara, Yoshiyuki

Subjects
CELIAC artery, SPLENIC artery, HEPATIC artery, GASTRECTOMY, LYMPHADENECTOMY
Abstract

Understanding anatomical anomalies of the branch of the celiac artery for safe gastrectomy is important. We report a case of laparoscopic distal gastrectomy with D1+ lymph node dissection for early gastric cancer with a vascular anatomical anomaly of the celiac artery. A 45‐year‐old woman was referred to our hospital because of early gastric cancer. Computed tomography showed an anatomical variation of the gastroduodenal artery, which branched from the celiac artery. The celiac artery also branched into the left gastric artery, the splenic artery, and the common hepatic artery. Preoperative understanding of an unusual branch of the celiac artery enabled a safe laparoscopic surgery. There were no postoperative complications. The Adachi classification or Michel classification is used for an anatomical anomaly of the celiac artery, but to the best of our knowledge, this case has not been previously classified and is the first reported case. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Right thoracoscopic resection in the supine position for recurrent pretracheal lymph nodes after esophagectomy

Author

Shishido, Yuji, primary, Matsunaga, Tomoyuki, additional, Yamasaki, Makoto, additional, Sakano, Yu, additional, Makinoya, Masahiro, additional, Miyauchi, Wataru, additional, Shimizu, Shota, additional, Miyatani, Kozo, additional, Kono, Yusuke, additional, Murakami, Yuki, additional, Hanaki, Takehiko, additional, Kihara, Kyoichi, additional, Yamamoto, Manabu, additional, Tokuyasu, Naruo, additional, Takano, Shuichi, additional, Sakamoto, Teruhisa, additional, Saito, Hiroaki, additional, Hasegawa, Toshimichi, additional, and Fujiwara, Yoshiyuki, additional

Published
2023
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23. Efficacy of indocyanine green systemic administration for bile leak detection after hepatectomy: a protocol for a prospective single-arm clinical trial with a historical control group

Author

Hanaki, Takehiko, primary, Goto, Keisuke, additional, Tokuyasu, Naruo, additional, Endo, Yusuke, additional, Sunada, Hiroshi, additional, Noma, Hisashi, additional, Sunaguchi, Teppei, additional, Murakami, Yuki, additional, Matsunaga, Tomoyuki, additional, Yamamoto, Manabu, additional, Sakamoto, Teruhisa, additional, Hasegawa, Toshimichi, additional, and Fujiwara, Yoshiyuki, additional

Published
2023
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25. Impact of Robot-Assisted Minimally Invasive Esophagectomy for Esophageal Cancer: A Propensity Score-Matched Short-Term Analysis

Author

Matsunaga, Tomoyuki, primary, Shishido, Yuji, additional, Saito, Hiroaki, additional, Sakano, Yu, additional, Makinoya, Masahiro, additional, Miyauchi, Wataru, additional, Shimizu, Shota, additional, Miyatani, Kozo, additional, Kono, Yusuke, additional, Murakami, Yuki, additional, Hanaki, Takehiko, additional, Kihara, Kyoichi, additional, Yamamoto, Manabu, additional, Tokuyasu, Naruo, additional, Takano, Shuichi, additional, Sakamoto, Teruhisa, additional, Hasegawa, Toshimichi, additional, and Fujiwara, Yoshiyuki, additional

Published
2023
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29. Simultaneous regulation of ferroptosis suppressor protein 1 and glutathione peroxidase 4 as a new therapeutic strategy of ferroptosis for esophageal squamous cell carcinoma.

Author

Miyauchi, Wataru, Shishido, Yuji, Matsumi, Yoshiaki, Matsunaga, Tomoyuki, Makinoya, Masahiro, Shimizu, Shota, Miyatani, Kozo, Sakamoto, Teruhisa, Umekita, Yoshihisa, Hasegawa, Toshimichi, and Fujiwara, Yoshiyuki

Abstract

Background: Ferroptosis suppressor protein 1 and glutathione peroxidase 4 have been identified as key molecules in two independent pathways associated with ferroptosis inhibition. This study investigated the prognostic significance and clinical associations of FSP1 and GPX4 expression in esophageal squamous cell carcinoma (ESCC) and assessed the therapeutic potential of regulating these molecules in ESCC cells. Methods: Immunohistochemical analysis was performed on surgical specimens of 97 patients with ESCC for FSP1 and GPX4 expression. To identify the change in ESCC cell viability, FSP1 and GPX4 inhibitors were administered to three cell lines. In addition, ferroptosis as the cause of reduced cell viability by FSP1 and GPX4 inhibition was confirmed. Results: Prognosis was significantly worse for patients in the group positive for both FSP1 and GPX4 compared with the other groups (p < 0.001). In multivariate analysis, positivity for both FSP1 and GPX4 was an independent poor prognostic factor (p = 0.002). The combination of FSP1 and GPX4 inhibitors induced cell death more potently than each inhibitor did alone. Furthermore, the ferroptosis inhibitor markedly canceled this cell death. Conclusions: Overexpression of FSP1 and GPX4 is a poor prognostic factor for patients with ESCC. Simultaneous suppression of both FSP1 and GPX4 caused potent cell death, which was markedly abrogated by ferroptosis inhibitors. These findings indicate that simultaneous regulation of FSP1 and GPX4 may be a new therapeutic target in ESCC. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Influence of the water jet system vs cavitron ultrasonic surgical aspirator for liver resection on the remnant liver

Author

Hanaki, Takehiko, primary, Tsuda, Ayumi, additional, Sunaguchi, Teppei, additional, Goto, Keisuke, additional, Morimoto, Masaki, additional, Murakami, Yuki, additional, Kihara, Kyoichi, additional, Matsunaga, Tomoyuki, additional, Yamamoto, Manabu, additional, Tokuyasu, Naruo, additional, Sakamoto, Teruhisa, additional, Hasegawa, Toshimichi, additional, and Fujiwara, Yoshiyuki, additional

Published
2022
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31. Laparoscopic cholecystectomy after percutaneous transhepatic gallbladder drainage for acute cholecystitis in a patient with a left ventricle assist device: A case report and brief review of the literature (with video)

Author

Hanaki, Takehiko, primary, Sunaguchi, Teppei, additional, Goto, Keisuke, additional, Morimoto, Masaki, additional, Murakami, Yuki, additional, Tokuyasu, Naruo, additional, Takano, Shuichi, additional, Sakamoto, Teruhisa, additional, Hasegawa, Toshimichi, additional, and Fujiwara, Yoshiyuki, additional

Published
2022
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33. Precancerous Pyloric Gland Metaplasia in the Biliary Epithelium Associated with Congenital Biliary Dilatation in a Three-Month-Old Infant

Author

Takano, Shuichi, Hasegawa, Toshimichi, Masuda, Kohga, Hanaki, Takehiko, Tokuyasu, Naruo, Sakamoto, Teruhisa, Nosaka, Kanae, Fujiwara, Yoshiyuki, Takano, Shuichi, Hasegawa, Toshimichi, Masuda, Kohga, Hanaki, Takehiko, Tokuyasu, Naruo, Sakamoto, Teruhisa, Nosaka, Kanae, and Fujiwara, Yoshiyuki

Abstract

Pyloric gland metaplasia in the biliary epithelium is a precancerous lesion and has been confirmed in patients with congenital biliary dilatation presenting with overt biliary tract cancer. A patient was found to have an intra-abdominal cyst on fetal ultrasonography and was born at 37 weeks of gestation with a body weight of 2,636 g. Abdominal distension and repeated vomiting appeared 2 days after birth. Congenital biliary dilatation was diagnosed by imaging, wherein the common bile duct was enlarged to 9–10 cm in size, and the surrounding organs were extensively compressed; however, there was no sign of pancreatitis or cholangitis. Biliary drainage was performed through the gallbladder at 6 days of age, but it was insufficient because of the narrow and twisted cystic duct and changed to common bile duct at 18 days to relieve the compression. Because the body weight gain was poor due to loss of large amount of bile, the dilated bile duct and gallbladder were resected and hepatic duct Roux-Y jejunostomy was performed at 115 days of age with 4,500 g of body weight. Intraoperative imaging showed a pancreaticobiliary maljunction, and the pancreatic enzyme activities of the bile in the biliary system were remarkably elevated. Histopathological examination revealed pyloric gland metaplasia in the gallbladder epithelium and cystic duct. The patient is now over 2 years old and has been doing well without any complications. Based on our experience, precancerous pyloric gland metaplasia of the biliary epithelium may already occur even in a 3-month-old infant presenting with congenital biliary dilatation.

Published
2022

34. The Significance of Surgical Intervention for Metasynchronous Liver Metastasis in Gastric Cancer: A Single-centre Analysis

Author

HANAKI, TAKEHIKO, primary, SUNAGUCHI, TEPPEI, additional, GOTO, KEISUKE, additional, MORIMOTO, MASAKI, additional, MURAKAMI, YUKI, additional, SHISHIDO, YUJI, additional, MIYATANI, KOZO, additional, KIHARA, KYOICHI, additional, MATSUNAGA, TOMOYUKI, additional, YAMAMOTO, MANABU, additional, TOKUYASU, NARUO, additional, SAKAMOTO, TERUHISA, additional, HASEGAWA, TOSHIMICHI, additional, and FUJIWARA, YOSHIYUKI, additional

Published
2022
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35. Combined analysis of preoperative and postoperative lymphocyte-C-reactive protein ratio precisely predicts outcomes of patients with gastric cancer

Author

Miyatani, Kozo, primary, Sawata, Shohei, additional, Makinoya, Masahiro, additional, Miyauchi, Wataru, additional, Shimizu, Shota, additional, Shishido, Yuji, additional, Matsunaga, Tomoyuki, additional, Yamamoto, Manabu, additional, Tokuyasu, Naruo, additional, Takano, Shuichi, additional, Sakamoto, Teruhisa, additional, Hasegawa, Toshimichi, additional, Saito, Hiroaki, additional, and Fujiwara, Yoshiyuki, additional

Published
2022
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36. Circular stapling anastomosis with indocyanine green fluorescence imaging for cervical esophagogastric anastomosis after thoracoscopic esophagectomy: A propensity score-matched analysis

Author

Shishido, Yuji, primary, Matsunaga, Tomoyuki, additional, Makinoya, Masahiro, additional, Miyauchi, Wataru, additional, Shimizu, Shota, additional, Miyatani, Kozo, additional, Uejima, Chihiro, additional, Morimoto, Masaki, additional, Murakami, Yuki, additional, Hanaki, Takehiko, additional, Kihara, Kyoichi, additional, Yamamoto, Manabu, additional, Tokuyasu, Naruo, additional, Takano, Shuichi, additional, Sakamoto, Teruhisa, additional, Saito, Hiroaki, additional, Hasegawa, Toshimichi, additional, and Fujiwara, Yoshiyuki, additional

Published
2022
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37. The Barthel Index for Predicting Postoperative Complications in Elderly Patients Undergoing Abdominal Surgery: A Prospective Single-center Study

Author

UCHINAKA, EI, primary, HANAKI, TAKEHIKO, additional, MORIMOTO, MASAKI, additional, MURAKAMI, YUKI, additional, TOMOYUKI, MATSUNAGA, additional, YAMAMOTO, MANABU, additional, TOKUYASU, NARUO, additional, SAKAMOTO, TERUHISA, additional, HASEGAWA, TOSHIMICHI, additional, and FUJIWARA, YOSHIYUKI, additional

Published
2022
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39. Infiltration of CD204-overexpressing Macrophages Contributes to the Progression of Stage II and III Colorectal Cancer

Author

TADA, YOICHIRO, primary, MATSUMI, YOSHIAKI, additional, HARA, KAZUSHI, additional, MIYAUCHI, WATARU, additional, SUGESAWA, KEN, additional, UEJIMA, CHIHIRO, additional, TANIO, AKIMITSU, additional, KIHARA, KYOICHI, additional, YAMAMOTO, MANABU, additional, TAKANO, SHUICHI, additional, SAKAMOTO, TERUHISA, additional, NAKAYAMA, YUJI, additional, HASEGAWA, TOSHIMICHI, additional, and FUJIWARA, YOSHIYUKI, additional

Published
2021
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40. 胃癌腹水中エクソソームに存在するmicroRNAの 臨床応用に向けた基礎的研究

Author

Miyatani, Kozo, Matsumi, Yoshiaki, Sawata, Shohei, Makinoya, Masahiro, Miyauchi, Wataru, Shishido, Yuji, Matsunaga, Tomoyuki, Sakamoto, Teruhisa, Hasegawa, Toshimichi, Horie, Atsushi, Fujiwara, Yoshiyuki, Miyatani, Kozo, Matsumi, Yoshiaki, Sawata, Shohei, Makinoya, Masahiro, Miyauchi, Wataru, Shishido, Yuji, Matsunaga, Tomoyuki, Sakamoto, Teruhisa, Hasegawa, Toshimichi, Horie, Atsushi, and Fujiwara, Yoshiyuki

Abstract

The purpose of this study is to explore the exosomal microRNAs obtained from peritoneal fluids of gastric cancer patients, which are specific for peritoneal metastasis （PM） and could be a predictive marker of disease status in PM. Exosomes were isolated from peritoneal fluids of patients of gastric cancer with PM. Presence of isolated extracellular vesicles （EVs） from peritoneal fluid specimens were confirmed using a transmission electron microscope showed that many EVs were approximately 100 nm in diameter, which were equivalent to exosome fractions. We carried out RNA extraction and comprehensive array analysis of exosomal microRNAs and have identified that 86 microRNAs were significantly up- or down-regulated in all 4 specimens and that out of them, miR-323-3p was highly expressed in all 4 cases. In this way, we have established an experimental system for measuring exosomal microRNAs in peritoneal lavage specimens. Next, we plan to apply this analysis for additional peritoneal lavage specimens obtained from gastric cancer patients with or without PM and to identify specific microRNAs, which could be predictive biomarkers for the disease status of PM in gastric cancer.

Published
2021

41. Ruptured Small Intestinal Stromal Tumor Causing Concurrent Gastrointestinal and Intra-Abdominal Hemorrhage: A Case Report

Author

Tada, Yoichiro, Yamamoto, Manabu, Sawata, Shohei, Hara, Kazushi, Sugesawa, Ken, Ueshima, Chihiro, Tanio, Akimitsu, Kihara, Kyoichi, Matsunaga, Tomoyuki, Tokuyasu, Naruo, Takano, Shuichi, Sakamoto, Teruhisa, Honjo, Soichiro, Hasegawa, Toshimichi, Fujiwara, Yoshiyuki, Tada, Yoichiro, Yamamoto, Manabu, Sawata, Shohei, Hara, Kazushi, Sugesawa, Ken, Ueshima, Chihiro, Tanio, Akimitsu, Kihara, Kyoichi, Matsunaga, Tomoyuki, Tokuyasu, Naruo, Takano, Shuichi, Sakamoto, Teruhisa, Honjo, Soichiro, Hasegawa, Toshimichi, and Fujiwara, Yoshiyuki

Abstract

Gastrointestinal stromal tumors (GISTs) originate from mesenchymal cells throughout the gastrointestinal tract. A common symptom is gastrointestinal hemorrhage; intra-abdominal hemorrhage is relatively rare. There are few reports of GIST presenting with both types of hemorrhage concurrently. A 77-year-old man was admitted to our hospital because of melena and anemia (Hb: 4.7 g/dL). Computed tomography revealed a small bowel tumor and high-density fluid in both the small intestine and the pelvic floor. We diagnosed a small intestinal tumor with concurrent gastrointestinal and intra-abdominal hemorrhage, and performed emergency surgery. The tumor arose from the small intestine and was ruptured. We found hemorrhage in the pelvic cavity and performed partial small intestine resection. Pathological findings revealed that the tumor was positive for c-Kit protein and was diagnosed as GIST. The patient was discharged from the hospital on postoperative day 9 and received imatinib 1 month postoperatively. We experienced a very rare case of ruptured GIST originating from the small intestine associated with both gastrointestinal and intra-abdominal hemorrhage. We also reviewed the relevant literature.

Published
2021

42. Clinical Significance of Serum Antithrombin III Activity After Hepatectomy for Hepatocellular Carcinoma

Author

Tokuyasu, Naruo, Amisaki, Masataka, Hanaki, Takehiko, Murakami, Yuki, Morimoto, Masaki, Uchinaka, Ei, Yagyu, Takuki, Goto, Keisuke, Matsunaga, Tomoyuki, Yamamoto, Manabu, Takano, Shuichi, Sakamoto, Teruhisa, Honjo, Soichiro, Hasegawa, Toshimichi, Fujiwara, Yoshiyuki, Tokuyasu, Naruo, Amisaki, Masataka, Hanaki, Takehiko, Murakami, Yuki, Morimoto, Masaki, Uchinaka, Ei, Yagyu, Takuki, Goto, Keisuke, Matsunaga, Tomoyuki, Yamamoto, Manabu, Takano, Shuichi, Sakamoto, Teruhisa, Honjo, Soichiro, Hasegawa, Toshimichi, and Fujiwara, Yoshiyuki

Abstract

[Background] As antithrombin III (AT-III) is produced in the hepatocytes, its serum activity decreases at the time of liver failure, in addition to ischemia reperfusion injury, vascular endothelial dysfunction, and disseminated intravascular coagulation (DIC). Here, we examined whether the serum AT-III value after hepatectomy could be a prognostic factor for hepatocellular carcinoma (HCC). [Methods] Of 141 patients who underwent hepatectomy for HCC, data for 101 patients in whom serum AT-III activity was measured on the first postoperative day were extracted. Patients with serum AT-III activity > 50% and ? 50% were assigned to high value (72 cases) and low value (29 cases) groups, respectively. We examined the clinical and prognostic differences between these two groups. [Results] The average age of enrolled patients (83 men and 18 women) was 68.0 years. The 5-year overall survival rate was 88% and 60% in the high and low value groups, respectively (P < 0.01). Furthermore, the 2-year relapse-free survival rate was 71% and 54% in the high and low value groups, respectively (P = 0.03). [Conclusion] This is the first study to demonstrate that serum AT-III levels on the first postoperative day may serve as a prognostic factor in HCC patients.

Published
2021

43. Platelet-to-Lymphocyte Ratio Multiplied by the Cytokeratin-19 Fragment Level as a Predictor of Pathological Response to Neoadjuvant Chemotherapy in Esophageal Squamous Cell Carcinoma

Author

Shishido, Yuji, Matsunaga, Tomoyuki, Sawata, Shohei, Makinoya, Masahiro, Miyauchi, Wataru, Miyatani, Kozo, Uejima, Chihiro, Morimoto, Masaki, Murakami, Yuki, Hanaki, Takehiko, Kihara, Kyoichi, Yamamoto, Manabu, Tokuyasu, Naruo, Takano, Shuichi, Sakamoto, Teruhisa, Saito, Hiroaki, Hasegawa, Toshimichi, Fujiwara, Yoshiyuki, Shishido, Yuji, Matsunaga, Tomoyuki, Sawata, Shohei, Makinoya, Masahiro, Miyauchi, Wataru, Miyatani, Kozo, Uejima, Chihiro, Morimoto, Masaki, Murakami, Yuki, Hanaki, Takehiko, Kihara, Kyoichi, Yamamoto, Manabu, Tokuyasu, Naruo, Takano, Shuichi, Sakamoto, Teruhisa, Saito, Hiroaki, Hasegawa, Toshimichi, and Fujiwara, Yoshiyuki

Abstract

[Background] The standard treatment for resectable advanced esophageal squamous cell carcinoma in Japan is surgery followed by neoadjuvant chemotherapy, and it is important to predict the effect of neoadjuvant chemotherapy before treatment. Therefore, this study aims to extract conventional blood examination data, such as tumor markers and/or inflammatory/nutritional index levels, that can predict the pathological response of patients with esophageal squamous cell carcinoma to neoadjuvant chemotherapy. [Methods] We retrospectively analyzed the medical records of 66 patients with thoracic esophageal squamous cell carcinoma who received neoadjuvant chemotherapy, followed by curative esophagectomy at Tottori University Hospital between June 2009 and December 2019. [Results] We demonstrated that the product of the platelet-to-lymphocyte ratio (PLR) multiplied by the cytokeratin-19 fragment (CYFRA) level, which was termed “PLR-CYFRA,” is the most accurate indicator that predicts the pathological response to neoadjuvant chemotherapy, with the highest area under the curve [0.795 (95% confidence interval: 0.665–0.925), P < 0.001] in receiver operating characteristic analyses. Therefore, we divided patients into the PLR-CYFRALow (< 237.6, n = 21) and PLR-CYFRAHigh (≥ 237.6, n = 45) groups and found that the percentage of PLR-CYFRALow was significantly higher in patients with a better pathological response (P < 0.001). Furthermore, patients with good pathological response had significantly better prognoses in terms of disease-specific survival (P = 0.014), recurrence-free survival (P = 0.014), and overall survival (P = 0.032). In the multivariate analysis, PLR-CYFRA was an independent predictor of the pathological response of patients with esophageal squamous cell carcinoma to neoadjuvant chemotherapy (P = 0.002). [Conclusion] Pretreatment PLR-CYFRA might be a useful and simple tool that predicts the pathological effect of neoadjuvant chemotherapy in esophageal squamous cell

Published
2021

49. Clinical Significance of Serum Antithrombin III Activity After Hepatectomy for Hepatocellular Carcinoma

Author

Tokuyasu, Naruo, primary, Amisaki, Masataka, additional, Hanaki, Takehiko, additional, Murakami, Yuki, additional, Morimoto, Masaki, additional, Uchinaka, Ei, additional, Yagyu, Takuki, additional, Goto, Keisuke, additional, Matsunaga, Tomoyuki, additional, Yamamoto, Manabu, additional, Takano, Shuichi, additional, Sakamoto, Teruhisa, additional, Honjo, Soichiro, additional, Hasegawa, Toshimichi, additional, and Fujiwara, Yoshiyuki, additional

Published
2021
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50. Ruptured Small Intestinal Stromal Tumor Causing Concurrent Gastrointestinal and Intra-Abdominal Hemorrhage: A Case Report

Author

Tada, Yoichiro, primary, Yamamoto, Manabu, additional, Sawata, Shohei, additional, Hara, Kazushi, additional, Sugesawa, Ken, additional, Ueshima, Chihiro, additional, Tanio, Akimitsu, additional, Kihara, Kyoichi, additional, Matsunaga, Tomoyuki, additional, Tokuyasu, Naruo, additional, Takano, Shuichi, additional, Sakamoto, Teruhisa, additional, Honjo, Soichiro, additional, Hasegawa, Toshimichi, additional, and Fujiwara, Yoshiyuki, additional

Published
2021
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