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325 results on '"Hasegawa, Naomi"'

1. Commensal consortia decolonize Enterobacteriaceae via ecological control

Author

Furuichi, Munehiro, Kawaguchi, Takaaki, Pust, Marie-Madlen, Yasuma-Mitobe, Keiko, Plichta, Damian R., Hasegawa, Naomi, Ohya, Takashi, Bhattarai, Shakti K., Sasajima, Satoshi, Aoto, Yoshimasa, Tuganbaev, Timur, Yaginuma, Mizuki, Ueda, Masahiro, Okahashi, Nobuyuki, Amafuji, Kimiko, Kiridoshi, Yuko, Sugita, Kayoko, Stražar, Martin, Avila-Pacheco, Julian, Pierce, Kerry, Clish, Clary B., Skelly, Ashwin N., Hattori, Masahira, Nakamoto, Nobuhiro, Caballero, Silvia, Norman, Jason M., Olle, Bernat, Tanoue, Takeshi, Suda, Wataru, Arita, Makoto, Bucci, Vanni, Atarashi, Koji, Xavier, Ramnik J., and Honda, Kenya

Published
2024
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2. Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification.

Author

Okada, Naohiro, Fukunaga, Masaki, Miura, Kenichiro, Nemoto, Kiyotaka, Matsumoto, Junya, Hashimoto, Naoki, Kiyota, Masahiro, Morita, Kentaro, Koshiyama, Daisuke, Ohi, Kazutaka, Takahashi, Tsutomu, Koeda, Michihiko, Yamamori, Hidenaga, Fujimoto, Michiko, Yasuda, Yuka, Hasegawa, Naomi, Narita, Hisashi, Yokoyama, Satoshi, Mishima, Ryo, Kawashima, Takahiko, Kobayashi, Yuko, Sasabayashi, Daiki, Harada, Kenichiro, Yamamoto, Maeri, Hirano, Yoji, Itahashi, Takashi, Nakataki, Masahito, Hashimoto, Ryu-Ichiro, Tha, Khin, Koike, Shinsuke, Matsubara, Toshio, Okada, Go, Jahanshad, Neda, Yoshimura, Reiji, Abe, Osamu, Onitsuka, Toshiaki, Watanabe, Yoshiyuki, Matsuo, Koji, Yamasue, Hidenori, Okamoto, Yasumasa, Suzuki, Michio, Turner, Jessica, Thompson, Paul, Ozaki, Norio, Kasai, Kiyoto, Hashimoto, Ryota, and Van Erp, Theodorus

Subjects
Humans, Schizophrenia, Depressive Disorder, Major, Bipolar Disorder, Female, Male, Magnetic Resonance Imaging, Adult, Neuroimaging, Brain, Autism Spectrum Disorder, Middle Aged, Mental Disorders, Organ Size
Abstract

Differential diagnosis is sometimes difficult in practical psychiatric settings, in terms of using the current diagnostic system based on presenting symptoms and signs. The creation of a novel diagnostic system using objective biomarkers is expected to take place. Neuroimaging studies and others reported that subcortical brain structures are the hubs for various psycho-behavioral functions, while there are so far no neuroimaging data-driven clinical criteria overcoming limitations of the current diagnostic system, which would reflect cognitive/social functioning. Prior to the main analysis, we conducted a large-scale multisite study of subcortical volumetric and lateralization alterations in schizophrenia, bipolar disorder, major depressive disorder, and autism spectrum disorder using T1-weighted images of 5604 subjects (3078 controls and 2526 patients). We demonstrated larger lateral ventricles volume in schizophrenia, bipolar disorder, and major depressive disorder, smaller hippocampus volume in schizophrenia and bipolar disorder, and schizophrenia-specific smaller amygdala, thalamus, and accumbens volumes and larger caudate, putamen, and pallidum volumes. In addition, we observed a leftward alteration of lateralization for pallidum volume specifically in schizophrenia. Moreover, as our main objective, we clustered the 5,604 subjects based on subcortical volumes, and explored whether data-driven clustering results can explain cognitive/social functioning in the subcohorts. We showed a four-biotype classification, namely extremely (Brain Biotype [BB] 1) and moderately smaller limbic regions (BB2), larger basal ganglia (BB3), and normal volumes (BB4), being associated with cognitive/social functioning. Specifically, BB1 and BB2-3 were associated with severe and mild cognitive/social impairment, respectively, while BB4 was characterized by normal cognitive/social functioning. Our results may lead to the future creation of novel biological data-driven psychiatric diagnostic criteria, which may be expected to be useful for prediction or therapeutic selection.

Published
2023

3. Cerebral cortical structural alteration patterns across four major psychiatric disorders in 5549 individuals.

Author

Matsumoto, Junya, Fukunaga, Masaki, Miura, Kenichiro, Nemoto, Kiyotaka, Okada, Naohiro, Hashimoto, Naoki, Morita, Kentaro, Koshiyama, Daisuke, Ohi, Kazutaka, Takahashi, Tsutomu, Koeda, Michihiko, Yamamori, Hidenaga, Fujimoto, Michiko, Yasuda, Yuka, Ito, Satsuki, Yamazaki, Ryuichi, Hasegawa, Naomi, Narita, Hisashi, Yokoyama, Satoshi, Mishima, Ryo, Miyata, Jun, Kobayashi, Yuko, Sasabayashi, Daiki, Harada, Kenichiro, Yamamoto, Maeri, Hirano, Yoji, Itahashi, Takashi, Nakataki, Masahito, Hashimoto, Ryu-Ichiro, Tha, Khin, Koike, Shinsuke, Matsubara, Toshio, Okada, Go, Yoshimura, Reiji, Abe, Osamu, Turner, Jessica, Jahanshad, Neda, Thompson, Paul, Onitsuka, Toshiaki, Watanabe, Yoshiyuki, Matsuo, Koji, Yamasue, Hidenori, Okamoto, Yasumasa, Suzuki, Michio, Ozaki, Norio, Kasai, Kiyoto, Hashimoto, Ryota, and Van Erp, Theodorus

Subjects
Humans, Depressive Disorder, Major, Autism Spectrum Disorder, Bipolar Disorder, Mental Disorders, Cerebral Cortex, Magnetic Resonance Imaging
Abstract

According to the operational diagnostic criteria, psychiatric disorders such as schizophrenia (SZ), bipolar disorder (BD), major depressive disorder (MDD), and autism spectrum disorder (ASD) are classified based on symptoms. While its cluster of symptoms defines each of these psychiatric disorders, there is also an overlap in symptoms between the disorders. We hypothesized that there are also similarities and differences in cortical structural neuroimaging features among these psychiatric disorders. T1-weighted magnetic resonance imaging scans were performed for 5,549 subjects recruited from 14 sites. Effect sizes were determined using a linear regression model within each protocol, and these effect sizes were meta-analyzed. The similarity of the differences in cortical thickness and surface area of each disorder group was calculated using cosine similarity, which was calculated from the effect sizes of each cortical regions. The thinnest cortex was found in SZ, followed by BD and MDD. The cosine similarity values between disorders were 0.943 for SZ and BD, 0.959 for SZ and MDD, and 0.943 for BD and MDD, which indicated that a common pattern of cortical thickness alterations was found among SZ, BD, and MDD. Additionally, a generally smaller cortical surface area was found in SZ and MDD than in BD, and the effect was larger in SZ. The cosine similarity values between disorders were 0.945 for SZ and MDD, 0.867 for SZ and ASD, and 0.811 for MDD and ASD, which indicated a common pattern of cortical surface area alterations among SZ, MDD, and ASD. Patterns of alterations in cortical thickness and surface area were revealed in the four major psychiatric disorders. To our knowledge, this is the first report of a cross-disorder analysis conducted on four major psychiatric disorders. Cross-disorder brain imaging research can help to advance our understanding of the pathogenesis of psychiatric disorders and common symptoms.

Published
2023

4. The effect of education regarding treatment guidelines for schizophrenia and major depressive disorders on psychiatrists' hypnotic medication prescribing behavior: a multicenter study

Author

Nakamura, Toshinori, Furihata, Ryuji, Hasegawa, Naomi, Kodaka, Fumitoshi, Muraoka, Hiroyuki, Ichihashi, Kayo, Ochi, Shinichiro, Numata, Shusuke, Tsuboi, Takashi, Makinodan, Manabu, Iida, Hitoshi, Onitsuka, Toshiaki, Kashiwagi, Hiroko, Takeshima, Masahiro, Hashimoto, Naoki, Nagasawa, Tatsuya, Usami, Masahide, Yamagata, Hirotaka, Takaesu, Yoshikazu, Miura, Kenichiro, Matsumoto, Junya, Ohi, Kazutaka, Yamada, Hisashi, Hori, Hikaru, Inada, Ken, Watanabe, Koichiro, Hashimoto, Ryota, and Yasui-Furukori, Norio

Published
2024
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7. Change of prescription for patients with schizophrenia or major depressive disorder during admission: real-world prescribing surveys from the effectiveness of guidelines for dissemination and education psychiatric treatment project

Author

Hashimoto, Naoki, Yasui-Furukori, Norio, Hasegawa, Naomi, Ishikawa, Shuhei, Hori, Hikaru, Iida, Hitoshi, Ichihashi, Kayo, Miura, Kenichiro, Matsumoto, Junya, Numata, Shusuke, Kodaka, Fumitoshi, Furihata, Ryuji, Ohi, Kazutaka, Ogasawara, Kazuyoshi, Iga, Jun-ichi, Muraoka, Hiroyuki, Komatsu, Hiroshi, Takeshima, Masahiro, Atake, Kiyokazu, Kido, Mikio, Nakamura, Toshinori, Kishimoto, Taishiro, Hishimoto, Akitoyo, Onitsuka, Toshiaki, Okada, Tsuyoshi, Ochi, Shinichiro, Nagasawa, Tatsuya, Makinodan, Manabu, Yamada, Hiroki, Tsuboi, Takashi, Yamada, Hisashi, Inada, Ken, Watanabe, Koichiro, and Hashimoto, Ryota

Published
2023
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9. Effect of the guideline education program on anticholinergic and benzodiazepine use in outpatients with schizophrenia and major depressive disorder: The effectiveness of guidelines for dissemination and education in psychiatric treatment (EGUIDE) project

Author

Yamagata, Hirotaka, Fujii, Yuko, Ochi, Shinichiro, Seki, Tomoe, Hasegawa, Naomi, Yamada, Hisashi, Hori, Hikaru, Ichihashi, Kayo, Iga, Jun-ichi, Ogasawara, Kazuyoshi, Hashimoto, Naoki, Iida, Hitoshi, Ohi, Kazutaka, Tsuboi, Takashi, Numata, Shusuke, Hishimoto, Akitoyo, Usami, Masahide, Katsumoto, Eiichi, Muraoka, Hiroyuki, Takaesu, Yoshikazu, Nagasawa, Tatsuya, Komatsu, Hiroshi, Miura, Kenichiro, Matsumoto, Junya, Inada, Ken, Nakagawa, Shin, and Hashimoto, Ryota

Published
2024
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12. Characteristics of the treatments for each severity of major depressive disorder: A real-world multi-site study

Author

Muraoka, Hiroyuki, Kodaka, Fumitoshi, Hasegawa, Naomi, Yasui-Furukori, Norio, Fukumoto, Kentaro, Kashiwagi, Hiroko, Tagata, Hiromi, Hori, Hikaru, Atake, Kiyokazu, Iida, Hitoshi, Ichihashi, Kayo, Furihata, Ryuji, Tsuboi, Takashi, Takeshima, Masahiro, Komatsu, Hiroshi, Kubota, Chika, Ochi, Shinichiro, Takaesu, Yoshikazu, Usami, Masahide, Nagasawa, Tatsuya, Makinodan, Manabu, Nakamura, Toshinori, Kido, Mikio, Ueda, Ikki, Yamagata, Hirotaka, Onitsuka, Toshiaki, Asami, Takeshi, Hishimoto, Akitoyo, Ogasawara, Kazuyoshi, Katsumoto, Eiichi, Miura, Kenichiro, Matsumoto, Junya, Ohi, Kazutaka, Yamada, Hisashi, Watanabe, Koichiro, Inada, Ken, Nishimura, Katsuji, and Hashimoto, Ryota

Published
2022
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13. The characteristics of discharge prescriptions including pro re nata psychotropic medications for patients with schizophrenia and major depressive disorder from the survey of the “Effectiveness of guidelines for dissemination and education in psychiatric treatment (EGUIDE)” project

Author

Kyou, Yoshitaka, Yasui-Furukori, Norio, Hasegawa, Naomi, Ide, Kenta, Ichihashi, Kayo, Hashimoto, Naoki, Hori, Hikaru, Shimizu, Yoshihito, Imamura, Yayoi, Muraoka, Hiroyuki, Iida, Hitoshi, Ohi, Kazutaka, Yasuda, Yuka, Ogasawara, Kazuyoshi, Numata, Shusuke, Iga, Jun-ichi, Tsuboi, Takashi, Ochi, Shinichiro, Kodaka, Fumitoshi, Furihata, Ryuji, Onitsuka, Toshiaki, Makinodan, Manabu, Komatsu, Hiroshi, Takeshima, Masahiro, Kubota, Chika, Hishimoto, Akitoyo, Atake, Kiyokazu, Yamagata, Hirotaka, Kido, Mikio, Nagasawa, Tatsuya, Usami, Masahide, Kishimoto, Taishiro, Kikuchi, Saya, Matsumoto, Junya, Miura, Kenichiro, Yamada, Hisashi, Watanabe, Koichiro, Inada, Ken, and Hahimoto, Ryota

Published
2022
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14. The characteristics of patients receiving psychotropic pro re nata medication at discharge for the treatment of schizophrenia and major depressive disorder: A nationwide survey from the EGUIDE project

Author

Ichihashi, Kayo, Kyou, Yoshitaka, Hasegawa, Naomi, Yasui-Furukori, Norio, Shimizu, Yoshihito, Hori, Hikaru, Hashimoto, Naoki, Ide, Kenta, Imamura, Yayoi, Yamada, Hisashi, Ochi, Shinichiro, Iga, Jun-ichi, Takaesu, Yoshikazu, Ohi, Kazutaka, Tsuboi, Takashi, Iida, Hitoshi, Yamagata, Hirotaka, Hishimoto, Akitoyo, Horai, Tadasu, Usami, Masahide, Makinodan, Manabu, Nagasawa, Tatsuya, Komatsu, Hiroshi, Kido, Mikio, Muraoka, Hiroyuki, Atake, Kiyokazu, Takeshima, Masahiro, Kubota, Chika, Inagaki, Takahiko, Tamai, Shinichiro, Kishimoto, Taishiro, Furihata, Ryuji, Matsumoto, Junya, Miura, Kenichiro, Inada, Ken, Watanabe, Koichiro, Kasai, Kiyoto, and Hashimoto, Ryota

Published
2022
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15. Hypnotic medication use among inpatients with schizophrenia and major depressive disorder: results of a nationwide study

Author

Furihata, Ryuji, Otsuki, Rei, Hasegawa, Naomi, Tsuboi, Takashi, Numata, Shusuke, Yasui-Furukori, Norio, Kashiwagi, Hiroko, Hori, Hikaru, Ochi, Shinichiro, Muraoka, Hiroyuki, Onitsuka, Toshiaki, Komatsu, Hiroshi, Takeshima, Masahiro, Hishimoto, Akitoyo, Nagasawa, Tatsuya, Takaesu, Yoshikazu, Nakamura, Toshinori, Asami, Takeshi, Miura, Kenichiro, Matsumoto, Junya, Ohi, Kazutaka, Yasuda, Yuka, Iida, Hitoshi, Ogasawara, Kazuyoshi, Hashimoto, Naoki, Ichihashi, Kayo, Yamada, Hisashi, Watanabe, Koichiro, Inada, Ken, and Hashimoto, Ryota

Published
2022
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16. Characteristics of discharge prescriptions for patients with schizophrenia or major depressive disorder: Real-world evidence from the Effectiveness of Guidelines for Dissemination and Education (EGUIDE) psychiatric treatment project

Author

Hashimoto, Naoki, Yasui-Furukori, Norio, Hasegawa, Naomi, Ishikawa, Shuhei, Numata, Shusuke, Hori, Hikaru, Iida, Hitoshi, Ichihashi, Kayo, Furihata, Ryuji, Murata, Atsunobu, Tsuboi, Takashi, Takeshima, Masahiro, Kyou, Yoshitaka, Komatsu, Hiroshi, Kubota, Chika, Ochi, Shinichiro, Takaesu, Yoshikazu, Usami, Masahide, Nagasawa, Tatsuya, Hishimoto, Akitoyo, Miura, Kenichiro, Matsumoto, Junya, Ohi, Kazutaka, Yamada, Hisashi, Inada, Ken, Watanabe, Koichiro, Shimoda, Kazutaka, and Hashimoto, Ryota

Published
2021
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17. An orbital calcific cyst following exenteration.

Author

Hasegawa, Naomi, Zhao, Jiawei, Greninger, Daniel A., Lu, Jonathan, Yoon, Michael K., Chen, Ying, and McCulley, Timothy J.

Subjects
*EXENTERATION, *MAGNETIC resonance imaging, *CYSTS (Pathology), *ORBITS (Astronomy), *SEBACEOUS gland diseases, *FIBROUS dysplasia of bone
Abstract

A 77-year-old Asian female with a history of left orbit exenteration and lid-sparing reconstruction for recurrent sebaceous carcinoma presented with fluid-like sensation of the left orbit. Magnetic resonance imaging (MRI) demonstrated bright T2 signal and a cyst-like cavity within the exenterated orbit. Decision was made to proceed with surgical exploration and excision. A calcified, bone-like cavity was encountered intraoperatively and removed. Histopathology revealed dense fibrous connective tissue with areas of calcification without osseous metaplasia, suggestive of retained blood in the orbit that underwent dystrophic calcification. This case report illustrates a rare occurrence of a bone-like calcific cyst following exenteration. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Longitudinal reduction in brain volume in patients with schizophrenia and its association with cognitive function

Author

Yamazaki, Ryuichi, primary, Matsumoto, Junya, additional, Ito, Satsuki, additional, Nemoto, Kiyotaka, additional, Fukunaga, Masaki, additional, Hashimoto, Naoki, additional, Kodaka, Fumitoshi, additional, Takano, Harumasa, additional, Hasegawa, Naomi, additional, Yasuda, Yuka, additional, Fujimoto, Michiko, additional, Yamamori, Hidenaga, additional, Watanabe, Yoshiyuki, additional, Miura, Kenichiro, additional, and Hashimoto, Ryota, additional

Published
2024
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19. Tablet-Based Cognitive and Eye Movement Measures as Accessible Tools in Schizophrenia Assessment: A Multi-Site Case-Control Study (Preprint)

Author

Morita, Kentaro, primary, Miura, Kenichiro, additional, Toyomaki, Atsuhito, additional, Makinodan, Manabu, additional, Ohi, Kazutaka, additional, Hashimoto, Naoki, additional, Yasuda, Yuka, additional, Mitsudo, Takako, additional, Higuchi, Fumihiro, additional, Numata, Shusuke, additional, Yamada, Akiko, additional, Aoki, Yohei, additional, Honda, Hiromitsu, additional, Mizui, Ryo, additional, Honda, Masato, additional, Fujikane, Daisuke, additional, Matsumoto, Junya, additional, Hasegawa, Naomi, additional, Ito, Satsuki, additional, Akiyama, Hisashi, additional, Onitsuka, Toshiaki, additional, Satomura, Yoshihiro, additional, Kasai, Kiyoto, additional, and Hashimoto, Ryota, additional

Published
2024
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21. Rationally-defined microbial consortia suppress multidrug-resistant proinflammatory Enterobacteriaceae via ecological control

Author

Honda, Kenya, primary, Furuichi, Munehiro, additional, Kawaguchi, Takaaki, additional, Pust, Marie-Madlen, additional, Yasuma-Mitobe, Keiko, additional, Plichta, Damian, additional, Hasegawa, Naomi, additional, Ohya, Takashi, additional, Bhattarai, Shakti, additional, Sasajima, Satoshi, additional, Yoshimasa, Aoto, additional, Tuganbaev, Timur, additional, Yaginuma, Mizuki, additional, Ueda, Masahiro, additional, Okahashi, Nobuyuki, additional, Amafuji, Kimiko, additional, Kiridooshi, Yuuko, additional, Sugita, Kayoko, additional, Stražar, Martin, additional, Skelly, Ashwin, additional, Suda, Wataru, additional, Hattori, Masahira, additional, Nakamoto, Nobuhiro, additional, Caballero, Silvia, additional, Norman, Jason, additional, Olle, Bernat, additional, Tanoue, Takeshi, additional, Arita, Makoto, additional, Bucci, Vanni, additional, Atarashi, Koji, additional, and Xavier, Ramnik, additional

Published
2023
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22. Effect of education regarding treatment guidelines for schizophrenia and depression on the treatment behavior of psychiatrists: A multicenter study

Author

Hasegawa, Naomi, primary, Yasuda, Yuka, additional, Yasui‐Furukori, Norio, additional, Yamada, Hisashi, additional, Hori, Hikaru, additional, Ichihashi, Kayo, additional, Takaesu, Yoshikazu, additional, Iida, Hitoshi, additional, Muraoka, Hiroyuki, additional, Kodaka, Fumitoshi, additional, Iga, Jun‐ichi, additional, Hashimoto, Naoki, additional, Ogasawara, Kazuyoshi, additional, Ohi, Kazutaka, additional, Fukumoto, Kentaro, additional, Numata, Shusuke, additional, Tsuboi, Takashi, additional, Usami, Masahide, additional, Hishimoto, Akitoyo, additional, Furihata, Ryuji, additional, Kishimoto, Taishiro, additional, Nakamura, Toshinori, additional, Katsumoto, Eiichi, additional, Ochi, Shinichiro, additional, Nagasawa, Tatsuya, additional, Atake, Kiyokazu, additional, Kubota, Chika, additional, Komatsu, Hiroshi, additional, Yamagata, Hirotaka, additional, Ide, Kenta, additional, Takeshima, Masahiro, additional, Kido, Mikio, additional, Kikuchi, Saya, additional, Okada, Tsuyoshi, additional, Matsumoto, Junya, additional, Miura, Kenichiro, additional, Shimazu, Taichi, additional, Inada, Ken, additional, Watanabe, Koichiro, additional, and Hashimoto, Ryota, additional

Published
2023
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23. Single-cell bioluminescence imaging of deep tissue in freely moving animals

Author

Iwano, Satoshi, Sugiyama, Mayu, Hama, Hiroshi, Watakabe, Akiya, Hasegawa, Naomi, Kuchimaru, Takahiro, Tanaka, Kazumasa Z., Takahashi, Megumu, Ishida, Yoko, Hata, Junichi, Shimozono, Satoshi, Namiki, Kana, Fukano, Takashi, Kiyama, Masahiro, Okano, Hideyuki, Kizaka-Kondoh, Shinae, McHugh, Thomas J., Yamamori, Tetsuo, Hioki, Hiroyuki, Maki, Shojiro, and Miyawaki, Atsushi

Published
2018

26. Relationships Between Adherence to Guideline Recommendations for Pharmacological Therapy Among Clinicians and Psychotic Symptoms in Patients With Schizophrenia

Author

Kodaka, Fumitoshi, primary, Ohi, Kazutaka, additional, Yasuda, Yuka, additional, Fujimoto, Michiko, additional, Yamamori, Hidenaga, additional, Hasegawa, Naomi, additional, Ito, Satsuki, additional, Fukumoto, Kentaro, additional, Matsumoto, Junya, additional, Miura, Kenichiro, additional, Yasui-Furukori, Norio, additional, and Hashimoto, Ryota, additional

Published
2023
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29. Combination Psychotropic Use for Schizophrenia With Long-Acting Injectable Antipsychotics and Oral Antipsychotics

Author

Onitsuka, Toshiaki, primary, Okada, Tsuyoshi, additional, Hasegawa, Naomi, additional, Tsuboi, Takashi, additional, Iga, Jun-ichi, additional, Yasui-Furukori, Norio, additional, Yamada, Naoki, additional, Hori, Hikaru, additional, Muraoka, Hiroyuki, additional, Ohi, Kazutaka, additional, Ogasawara, Kazuyoshi, additional, Shinichiro, Ochi, additional, Takeshima, Masahiro, additional, Ichihashi, Kayo, additional, Fukumoto, Kentaro, additional, Iida, Hitoshi, additional, Yamada, Hisashi, additional, Furihata, Ryuji, additional, Makinodan, Manabu, additional, Takaesu, Yoshikazu, additional, Numata, Shusuke, additional, Komatsu, Hiroshi, additional, Hishimoto, Akitoyo, additional, Kido, Mikio, additional, Atake, Kiyokazu, additional, Yamagata, Hirotaka, additional, Kikuchi, Saya, additional, Hashimoto, Naoki, additional, Usami, Masahide, additional, Katsumoto, Eiichi, additional, Asami, Takeshi, additional, Kubota, Chika, additional, Matsumoto, Junya, additional, Miura, Kenichiro, additional, Hirano, Yoji, additional, Watanabe, Koichiro, additional, Inada, Ken, additional, and Hashimoto, Ryota, additional

Published
2023
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31. Change of prescription for patients with schizophrenia or major depressive disorder during admission: Real-world evidence from the Effectiveness of Guidelines for Dissemination and Education psychiatric treatment project

Author

Hashimoto, Naoki, primary, Yasui-Furukori, Norio, additional, Hasegawa, Naomi, additional, Ishikawa, Shuhei, additional, Hori, Hikaru, additional, Iida, Hitoshi, additional, Ichihashi, Kayo, additional, Miura, Kenichiro, additional, Matsumoto, Junya, additional, Numata, Shusuke, additional, Kodaka, Fumitoshi, additional, Furihata, Ryuji, additional, Ohi, Kazutaka, additional, Ogasawara, Kazuyoshi, additional, Iga, Jun-ichi, additional, Muraoka, Hiroyuki, additional, Komatsu, Hiroshi, additional, Takeshima, Masahiro, additional, Atake, Kiyokazu, additional, Kido, Mikio, additional, Nakamura, Toshinori, additional, Kishimoto, Taishiro, additional, Hishimoto, Akitoyo, additional, Onitsuka, Toshiaki, additional, Okada, Tsuyoshi, additional, Ochi, Shinichiro, additional, Nagasawa, Tatsuya, additional, Makinodan, Manabu, additional, Yamada, Hiroki, additional, Tsuboi, Takashi, additional, Yamada, Hisashi, additional, Inada, Ken, additional, Watanabe, Koichiro, additional, and Hashimoto, Ryota, additional

Published
2023
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34. Subcortical volumetric alterations in four major psychiatric disorders: A mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification

Author

Hashimoto, Ryota, primary, Okada, Naohiro, additional, Fukunaga, Masaki, additional, Miura, Kenichiro, additional, Nemoto, Kiyotaka, additional, Matsumoto, Junya, additional, Hashimoto, Naoki, additional, Kiyota, Masahiro, additional, Morita, Kentaro, additional, Koshiyama, Daisuke, additional, Ohi, Kazutaka, additional, Takahashi, Tsutomu, additional, Koeda, Michihiko, additional, Yamamori, Hidenaga, additional, Fujimoto, Michiko, additional, Yasuda, Yuka, additional, Hasegawa, Naomi, additional, Narita, Hisashi, additional, Yokoyama, Satoshi, additional, Mishima, Ryo, additional, Kawashima, Takahiko, additional, Kobayashi, Yuko, additional, Sasabayashi, Daiki, additional, Harada, Kenichiro, additional, Yamamoto, Maeri, additional, Hirano, Yoji, additional, Itahashi, Takashi, additional, Nakataki, Masahito, additional, Hashimoto, Ryuichiro, additional, Tha, Khin, additional, Koike, Shinsuke, additional, Matsubara, Toshio, additional, Okada, Go, additional, Erp, Theo van, additional, Jahanshad, Neda, additional, Yoshimura, Reiji, additional, Abe, Osamu, additional, Onitsuka, Toshiaki, additional, Watanabe, Yoshiyuki, additional, Matsuo, Koji, additional, Yamasue, Hidenori, additional, Okamoto, Yasumasa, additional, Suzuki, Michio, additional, Turner, Jessica, additional, Thompson, Paul, additional, Ozaki, Norio, additional, and Kasai, Kiyoto, additional

Published
2023
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37. Satisfaction with web‐based courses on clinical practice guidelines for psychiatrists: Findings from the “Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE)” project

Author

Iida, Hitoshi, primary, Okada, Tsuyoshi, additional, Nemoto, Kiyotaka, additional, Hasegawa, Naomi, additional, Numata, Shusuke, additional, Ogasawara, Kazuyoshi, additional, Miura, Kenichiro, additional, Matsumoto, Junya, additional, Hori, Hikaru, additional, Iga, Jun‐ichi, additional, Ichihashi, Kayo, additional, Hashimoto, Naoki, additional, Yamada, Hisashi, additional, Ohi, Kazutaka, additional, Yasui‐Furukori, Norio, additional, Fukumoto, Kentaro, additional, Tsuboi, Takashi, additional, Usami, Masahide, additional, Furihata, Ryuji, additional, Takaesu, Yoshikazu, additional, Hishimoto, Akitoyo, additional, Muraoka, Hiroyuki, additional, Katsumoto, Eiichi, additional, Nagasawa, Tatsuya, additional, Ochi, Shinichiro, additional, Komatsu, Hiroshi, additional, Kikuchi, Saya, additional, Takeshima, Masahiro, additional, Onitsuka, Toshiaki, additional, Tamai, Shinichiro, additional, Kubota, Chika, additional, Inada, Ken, additional, Watanabe, Koichiro, additional, Kawasaki, Hiroaki, additional, and Hashimoto, Ryota, additional

Published
2022
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38. Development of an individual fitness score ( IFS ) based on the depression treatment guidelines of in the Japanese Society of Mood Disorders

Author

Fukumoto, Kentaro, primary, Kodaka, Fumitoshi, additional, Hasegawa, Naomi, additional, Muraoka, Hiroyuki, additional, Hori, Hikaru, additional, Ichihashi, Kayo, additional, Yasuda, Yuka, additional, Iida, Hitoshi, additional, Ohi, Kazutaka, additional, Ochi, Shinichiro, additional, Ide, Kenta, additional, Hashimoto, Naoki, additional, Usami, Masahide, additional, Nakamura, Toshinori, additional, Komatsu, Hiroshi, additional, Okada, Tsuyoshi, additional, Nagasawa, Tatsuya, additional, Furihata, Ryuji, additional, Atake, Kiyokazu, additional, Kido, Mikio, additional, Kikuchi, Saya, additional, Yamagata, Hirotaka, additional, Kishimoto, Taishiro, additional, Makinodan, Manabu, additional, Horai, Tadasu, additional, Takeshima, Masahiro, additional, Kubota, Chika, additional, Asami, Takeshi, additional, Katsumoto, Eiichi, additional, Hishimoto, Akitoyo, additional, Onitsuka, Toshiaki, additional, Matsumoto, Junya, additional, Miura, Kenichiro, additional, Yamada, Hisashi, additional, Yasui‐Furukori, Norio, additional, Watanabe, Koichiro, additional, Inada, Ken, additional, Otsuka, Kotaro, additional, and Hashimoto, Ryota, additional

Published
2022
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39. Effects of electroconvulsive therapy on the use of anxiolytics and sleep medications: a propensity score‐matched analysis

Author

Tsuboi, Takashi, primary, Takaesu, Yoshikazu, additional, Hasegawa, Naomi, additional, Ochi, Shinichiro, additional, Fukumoto, Kentaro, additional, Ohi, Kazutaka, additional, Muraoka, Hiroyuki, additional, Okada, Tsuyoshi, additional, Kodaka, Funitoshi, additional, Igarashi, Shun, additional, Iida, Hitoshi, additional, Kashiwagi, Hiroko, additional, Hori, Hikaru, additional, Ichihashi, Kayo, additional, Ogasawara, Kazuyoshi, additional, Hashimoto, Naoki, additional, Iga, Jun‐ichi, additional, Nakamura, Toshinori, additional, Usami, Masahide, additional, Nagasawa, Tatsuya, additional, Kido, Mikio, additional, Komatsu, Hiroshi, additional, Yamagata, Hirotaka, additional, Atake, Kiyokazu, additional, Furihata, Ryuji, additional, Kikuchi, Saya, additional, Horai, Tadasu, additional, Takeshima, Masahiro, additional, Hirano, Yoji, additional, Makinodan, Manabu, additional, Matsumoto, Junya, additional, Miura, Kenichiro, additional, Hishimoto, Akitoyo, additional, Numata, Shusuke, additional, Yamada, Hisashi, additional, Yasui‐Furukori, Norio, additional, Inada, Ken, additional, Watanabe, Koichiro, additional, and Hashimoto, Ryota, additional

Published
2022
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40. Development of individual fitness score for conformity of prescriptions to the “Guidelines For Pharmacological Therapy of Schizophrenia”

Author

Inada, Ken, primary, Fukumoto, Kentaro, additional, Hasegawa, Naomi, additional, Yasuda, Yuka, additional, Yamada, Hisashi, additional, Hori, Hikaru, additional, Ichihashi, Kayo, additional, Iida, Hitoshi, additional, Ohi, Kazutaka, additional, Muraoka, Hiroyuki, additional, Kodaka, Fumitoshi, additional, Ide, Kenta, additional, Hashimoto, Naoki, additional, Iga, Jun‐ichi, additional, Ogasawara, Kazuyoshi, additional, Atake, Kiyokazu, additional, Takaesu, Yoshikazu, additional, Nagasawa, Tatsuya, additional, Komatsu, Hiroshi, additional, Okada, Tsuyoshi, additional, Furihata, Ryuji, additional, Kido, Mikio, additional, Kikuchi, Saya, additional, Kubota, Chika, additional, Makinodan, Manabu, additional, Ochi, Shinichiro, additional, Takeshima, Masahiro, additional, Yamagata, Hirotaka, additional, Matsumoto, Junya, additional, Miura, Kenichiro, additional, Usami, Masahide, additional, Kishimoto, Taishiro, additional, Onitsuka, Toshiaki, additional, Katsumoto, Eiichi, additional, Hishimoto, Akitoyo, additional, Numata, Shusuke, additional, Yasui‐Furukori, Norio, additional, Watanabe, Koichiro, additional, and Hashimoto, Ryota, additional

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2022
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41. Second-Generation Antipsychotic Monotherapy Contributes to the Discontinuation of Anticholinergic Drugs in Hospitalized Patients With Schizophrenia

Author

Okada, Tsuyoshi, primary, Hori, Hikaru, additional, Hasegawa, Naomi, additional, Murata, Atsunobu, additional, Kyou, Yoshitaka, additional, Kodaka, Fumitoshi, additional, Iida, Hitoshi, additional, Ochi, Shinichiro, additional, Takaesu, Yoshikazu, additional, Tsuboi, Takashi, additional, Iga, Jun-ichi, additional, Ichihashi, Kayo, additional, Muraoka, Hiroyuki, additional, Furihata, Ryuji, additional, Yasui-Furukori, Norio, additional, Usami, Masahide, additional, Onitsuka, Toshiaki, additional, Ogasawara, Kazuyoshi, additional, Tagata, Hiromi, additional, Takeshima, Masahiro, additional, Ohi, Kazutaka, additional, Numata, Shusuke, additional, Hashimoto, Naoki, additional, Yamada, Hiroki, additional, Makinodan, Manabu, additional, Komatsu, Hiroshi, additional, Hishimoto, Akitoyo, additional, Yamagata, Hirotaka, additional, Kido, Mikio, additional, Kubota, Chika, additional, Atake, Kiyokazu, additional, Yamada, Hisashi, additional, Nagasawa, Tatsuya, additional, Matsumoto, Junya, additional, Miura, Kenichiro, additional, Inada, Ken, additional, Watanabe, Koichiro, additional, Suda, Shiro, additional, and Hashimoto, Ryota, additional

Published
2022
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42. Community-Based Interprofessional Education at Saitama Prefectural University

Author

Otsuka, Mariko, Shimazaki, Midori, Kayaba, Kazunori, Sakada, Takanori, Hara, Kazuhiko, Asahi, Masaya, Arai, Toshitami, Murohashi, Ikuo, Yokoyama, Keiko, Hasegawa, Naomi, Kawamata, Minoru, Suzuki, Reiko, Fujii, Chiyo, Kunisawa, Naoko, Kanemune, Miyuki, Shimasue, Noriko, Shinmura, Hiromi, Nishihara, Ken, Inoue, Kazuhisa, Ogawa, Kumi, Tano, Rumi, Watanabe, Hideomi, editor, and Koizumi, Misako, editor

Published
2010
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43. Discrimination in the clinical diagnosis between patients with schizophrenia and healthy controls using eye movement and cognitive functions.

Author

Okazaki, Kosuke, Miura, Kenichiro, Matsumoto, Junya, Hasegawa, Naomi, Fujimoto, Michiko, Yamamori, Hidenaga, Yasuda, Yuka, Makinodan, Manabu, and Hashimoto, Ryota

Subjects
EYE movements, COGNITIVE ability, COGNITIVE testing, WECHSLER Adult Intelligence Scale, PEOPLE with schizophrenia
Abstract

Aim: Eye movements and cognitive functions are significantly impaired in patients with schizophrenia. The authors aimed to develop promising clinical diagnostic markers that fit practical digital health applications in psychiatry using eye movement and cognitive function data from 1254 healthy individuals and 336 patients with schizophrenia. Methods: Multivariate analyses using logistic regression were performed to confirm net performance of eye movements and cognitive functions scored using the Wechsler Adult Intelligence Scale, Third Edition, and Wechsler Memory Scale‐Revised. The authors then examined the discrimination performance of pairs containing an eye movement and a cognitive function measure to search the pairs that would be effective in practical application for the discrimination according to the diagnostic criterion between the groups. Results: Multivariate analyses confirmed that eye movements and cognitive functions were effective modalities for discriminating between patients with schizophrenia and healthy controls. The discriminant analyses of the pairs demonstrated that seven eye movement measures and seven scores from cognitive function tests showed high discrimination performance when paired with one measure from the other modality. Moreover, seven pairs of digit‐symbol coding or symbol‐search and eye movement measures had high and robust discrimination performance. Conclusion: Seven pairs of an eye movement and a cognitive function measure were effective, robust, and less time‐consuming in assisting with clinical diagnosis by categorizing healthy individuals or patients with schizophrenia. These findings may help develop an objective auxiliary diagnosis method working even on portable devices, which facilitates the consistency of diagnosis, earlier intervention, and shared decision‐making. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Clozapine Treatment Is Associated With Higher Prescription Rate of Antipsychotic Monotherapy and Lower Prescription Rate of Other Concomitant Psychotropics: A Real-World Nationwide Study

Author

Ochi, Shinichiro, primary, Tagata, Hiromi, additional, Hasegawa, Naomi, additional, Yasui-Furukori, Norio, additional, Iga, Jun-ichi, additional, Kashiwagi, Hiroko, additional, Kodaka, Fumitoshi, additional, Komatsu, Hiroshi, additional, Tsuboi, Takashi, additional, Tokutani, Akira, additional, Numata, Shusuke, additional, Ichihashi, Kayo, additional, Onitsuka, Toshiaki, additional, Muraoka, Hiroyuki, additional, Iida, Hitoshi, additional, Ohi, Kazutaka, additional, Atake, Kiyokazu, additional, Kishimoto, Taishiro, additional, Hori, Hikaru, additional, Takaesu, Yoshikazu, additional, Takeshima, Masahiro, additional, Usami, Masahide, additional, Makinodan, Manabu, additional, Hashimoto, Naoki, additional, Fujimoto, Michiko, additional, Furihata, Ryuji, additional, Nagasawa, Tatsuya, additional, Yamada, Hisashi, additional, Matsumoto, Junya, additional, Miura, Kenichiro, additional, Kido, Mikio, additional, Hishimoto, Akitoyo, additional, Ueno, Shu-ichi, additional, Watanabe, Koichiro, additional, Inada, Ken, additional, and Hashimoto, Ryota, additional

Published
2022
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48. Hypnotic medication use among inpatients with schizophrenia and major depressive disorder: results of a nationwide study

Author

40727830, Furihata, Ryuji, Otsuki, Rei, Hasegawa, Naomi, Tsuboi, Takashi, Numata, Shusuke, Yasui-Furukori, Norio, Kashiwagi, Hiroko, Hori, Hikaru, Ochi, Shinichiro, Muraoka, Hiroyuki, Onitsuka, Toshiaki, Komatsu, Hiroshi, Takeshima, Masahiro, Hishimoto, Akitoyo, Nagasawa, Tatsuya, Takaesu, Yoshikazu, Nakamura, Toshinori, Asami, Takeshi, Miura, Kenichiro, Matsumoto, Junya, Ohi, Kazutaka, Yasuda, Yuka, Iida, Hitoshi, Ogasawara, Kazuyoshi, Hashimoto, Naoki, Ichihashi, Kayo, Yamada, Hisashi, Watanabe, Koichiro, Inada, Ken, Hashimoto, Ryota, 40727830, Furihata, Ryuji, Otsuki, Rei, Hasegawa, Naomi, Tsuboi, Takashi, Numata, Shusuke, Yasui-Furukori, Norio, Kashiwagi, Hiroko, Hori, Hikaru, Ochi, Shinichiro, Muraoka, Hiroyuki, Onitsuka, Toshiaki, Komatsu, Hiroshi, Takeshima, Masahiro, Hishimoto, Akitoyo, Nagasawa, Tatsuya, Takaesu, Yoshikazu, Nakamura, Toshinori, Asami, Takeshi, Miura, Kenichiro, Matsumoto, Junya, Ohi, Kazutaka, Yasuda, Yuka, Iida, Hitoshi, Ogasawara, Kazuyoshi, Hashimoto, Naoki, Ichihashi, Kayo, Yamada, Hisashi, Watanabe, Koichiro, Inada, Ken, and Hashimoto, Ryota

Abstract

[Study objectives] To investigate the proportion of inpatients with schizophrenia and major depressive disorder prescribed hypnotic medication, and the association between such medication and the use of other antipsychotic agents. [Methods] This was a nationwide cross-sectional study performed as part of the ‘Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment’ (EGUIDE) project. Data from 2146 inpatients with schizophrenia and 1031 inpatients with major depressive disorder were analyzed. All types and dosages of psychotropic drugs were recorded and the data at the time of discharge were analyzed. Associations between the use of hypnotic medication and other antipsychotic agents were evaluated using multivariate logistic regression analyses. [Results] The proportions of schizophrenia patients who were prescribed any and two or more hypnotic agents were 55.7% and 17.6%, respectively, and the corresponding proportions for patients with major depressive disorder were 63.6% and 22.6%, respectively. In schizophrenia patients, multivariate logistic regression analyses showed that two or more antipsychotics, anticholinergic drugs, anxiolytics, and mood stabilizers/antiepileptic drugs were positively associated with the use of any hypnotic agent. In patients with major depressive disorder, multivariate logistic regression analyses revealed that two or more antidepressants, two or more antipsychotics, anxiolytics, and mood stabilizers/antiepileptic drugs were positively associated with the use of any hypnotic agent. [Conclusions] Prescription of hypnotic agents was found to be highly frequent among inpatients with psychiatric disorders. Prescription of two or more main antipsychotic agents was commonly associated with the use of hypnotic medication for both schizophrenia and major depressive disorder.

Published
2022

49. Development of individual fitness score for conformity of prescriptions to the “Guidelines For Pharmacological Therapy of Schizophrenia”

Author

Inada, Ken, Fukumoto, Kentaro, Hasegawa, Naomi, Yasuda, Yuka, Yamada, Hisashi, Hori, Hikaru, Ichihashi, Kayo, Iida, Hitoshi, Ohi, Kazutaka, Muraoka, Hiroyuki, Kodaka, Fumitoshi, Ide, Kenta, Hashimoto, Naoki, Iga, Jun-ichi, Ogasawara, Kazuyoshi, Atake, Kiyokazu, Takaesu, Yoshikazu, Nagasawa, Tatsuya, Komatsu, Hiroshi, Okada, Tsuyoshi, Furihata, Ryuji, Kido, Mikio, Kikuchi, Saya, Kubota, Chika, Makinodan, Manabu, Ochi, Shinichiro, Takeshima, Masahiro, Yamagata, Hirotaka, Matsumoto, Junya, Miura, Kenichiro, Usami, Masahide, Kishimoto, Taishiro, Onitsuka, Toshiaki, Katsumoto, Eiichi, Hishimoto, Akitoyo, Numata, Shusuke, Yasui-Furukori, Norio, Watanabe, Koichiro, Hashimoto, Ryota, Inada, Ken, Fukumoto, Kentaro, Hasegawa, Naomi, Yasuda, Yuka, Yamada, Hisashi, Hori, Hikaru, Ichihashi, Kayo, Iida, Hitoshi, Ohi, Kazutaka, Muraoka, Hiroyuki, Kodaka, Fumitoshi, Ide, Kenta, Hashimoto, Naoki, Iga, Jun-ichi, Ogasawara, Kazuyoshi, Atake, Kiyokazu, Takaesu, Yoshikazu, Nagasawa, Tatsuya, Komatsu, Hiroshi, Okada, Tsuyoshi, Furihata, Ryuji, Kido, Mikio, Kikuchi, Saya, Kubota, Chika, Makinodan, Manabu, Ochi, Shinichiro, Takeshima, Masahiro, Yamagata, Hirotaka, Matsumoto, Junya, Miura, Kenichiro, Usami, Masahide, Kishimoto, Taishiro, Onitsuka, Toshiaki, Katsumoto, Eiichi, Hishimoto, Akitoyo, Numata, Shusuke, Yasui-Furukori, Norio, Watanabe, Koichiro, and Hashimoto, Ryota

Abstract

Aims: The Guidelines for the Pharmacotherapy of Schizophrenia were established to improve the quality of medical care, and the EGUIDE project was conducted to train clinicians on guideline usage. A quality indicator (QI) was established to measure the prevalence of the guidelines, and a survey was conducted, which revealed a gap between the guidelines and actual clinical practice (evidence-practice- gap). The purpose of this study was to develop an individual fitness score (IFS) formula that expresses the degree to which prescribers adhere to the Guidelines for Pharmacological Therapy of Schizophrenia in a simple manner, and to determine the validity of this formula from a survey of the prescriptions of the EGUIDE project participants'. Methods: To establish appropriate scores, members discussed the proposed formula and then voted on them. The IFS formula developed was set up so that antipsychotic monotherapy would be given 100 points, with points deducted if concomitant or adjunctive antipsychotic medications were used, and a minimum score of 0. To validate this formula, prescriptions of hospitalized schizophrenic patients at admission and at discharge were scored and compared. Result: IFS points vary and ranged from 0 to100. The average pre-admission score for all subjects was 45.6, and the average score at discharge was 54, those were significantly higher during discharge. Conclusions: We developed an IFS formula, a tool to easily visualize the degree to which current prescriptions conform to the guidelines for the pharmacological treatment of schizophrenia.

Published
2022

50. Prescription of Anticholinergic Drugs in Patients With Schizophrenia: Analysis of Antipsychotic Prescription Patterns and Hospital Characteristics

Author

Hori, Hikaru, Yasui-Furukori, Norio, Hasegawa, Naomi, Iga, Jun-ichi, Ochi, Shinichiro, Ichihashi, Kayo, Furihata, Ryuji, Kyo, Yoshitaka, Takaesu, Yoshikazu, Tsuboi, Takashi, Kodaka, Fumitoshi, Onitsuka, Toshiaki, Okada, Tsuyoshi, Murata, Atsunobu, Kashiwagi, Hiroko, Iida, Hitoshi, Hashimoto, Naoki, Ohi, Kazutaka, Yamada, Hisashi, Ogasawara, Kazuyoshi, Yasuda, Yuka, Muraoka, Hiroyuki, Usami, Masahide, Numata, Shusuke, Takeshima, Masahiro, Yamagata, Hirotaka, Nagasawa, Tatsuya, Tagata, Hiromi, Makinodan, Manabu, Kido, Mikio, Katsumoto, Eiichi, Komatsu, Hiroshi, Matsumoto, Junya, Kubota, Chika, Miura, Kenichiro, Hishimoto, Akitoyo, Watanabe, Koichiro, Inada, Ken, Kawasaki, Hiroaki, Hashimoto, Ryota, Hori, Hikaru, Yasui-Furukori, Norio, Hasegawa, Naomi, Iga, Jun-ichi, Ochi, Shinichiro, Ichihashi, Kayo, Furihata, Ryuji, Kyo, Yoshitaka, Takaesu, Yoshikazu, Tsuboi, Takashi, Kodaka, Fumitoshi, Onitsuka, Toshiaki, Okada, Tsuyoshi, Murata, Atsunobu, Kashiwagi, Hiroko, Iida, Hitoshi, Hashimoto, Naoki, Ohi, Kazutaka, Yamada, Hisashi, Ogasawara, Kazuyoshi, Yasuda, Yuka, Muraoka, Hiroyuki, Usami, Masahide, Numata, Shusuke, Takeshima, Masahiro, Yamagata, Hirotaka, Nagasawa, Tatsuya, Tagata, Hiromi, Makinodan, Manabu, Kido, Mikio, Katsumoto, Eiichi, Komatsu, Hiroshi, Matsumoto, Junya, Kubota, Chika, Miura, Kenichiro, Hishimoto, Akitoyo, Watanabe, Koichiro, Inada, Ken, Kawasaki, Hiroaki, and Hashimoto, Ryota

Abstract

In several clinical guidelines for schizophrenia, long-term use of anticholinergic drugs is not recommended. We investigated the characteristics of the use of anticholinergics in patients with schizophrenia by considering psychotropic prescription patterns and differences among hospitals. A cross-sectional, retrospective prescription survey at the time of discharge was conducted on 2027 patients with schizophrenia from 69 Japanese hospitals. We examined the relations among psychotropic drug prescriptions regarding anticholinergic prescription. We divided the hospitals into three groups— low rate group (LG), medium rate group (MG), and high rate group (HG)—according to their anticholinergic prescription rates, and analyzed the relationship between anticholinergic prescription rates and antipsychotic prescription. Anticholinergic drugs were prescribed to 618 patients (30.5%), and the prescription rates were significantly higher for high antipsychotic doses, antipsychotic polypharmacy, and first-generation antipsychotics (FGAs) use. The anticholinergic prescription rate varied considerably among hospitals, ranging from 0 to 66.7%, and it was significantly higher in patients with antipsychotic monotherapy, antipsychotic polypharmacy, and normal and high doses of antipsychotics in HG than in those LG and MG. The anticholinergics prescription rate in patients with second-generation antipsychotic monotherapy in HG was also significantly higher than in those LG and MG; however, the difference was no longer significant in patients with FGA monotherapy. Conclusively, in addition to high antipsychotic doses, antipsychotic polypharmacy, and FGA use, hospital characteristics influence the prescribing of anticholinergic drugs.

Published
2022

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