16 results on '"Hasanpour Z"'
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2. Effects of Salinity and Water Stress on Echophysiological Parameters and Micronutrients Concentration of Pomegranate (Punica granatumL.)
- Author
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Hasanpour, Z., primary, Karimi, H. R., additional, and Mirdehghan, S. H., additional
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- 2014
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3. Effects of Salinity and Water Stress on Echophysiological Parameters and Micronutrients Concentration of Pomegranate ( Punica granatum L.).
- Author
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Hasanpour, Z., Karimi, H. R., and Mirdehghan, S. H.
- Subjects
- *
PLANT nutrients , *SOIL salinity , *PLANT growing media , *DROUGHTS , *POMEGRANATE - Abstract
In order to study the effects of salinity and drought stress on echophysiological parameters and micronutrients concentration of pomegranate leaves, a factorial experiment was conducted based on completely randomized design with 0, 30, and 60 mM of salinity levels of sodium chloride and calcium chloride (1:1) and three irrigation intervals (2, 4, and 6 days) with three replications on ‘Rabab’ and ‘Shishegap’ cultivars of pomegranate. The results analysis of shoot and root indicated that the water salinity and drought affected the concentration of iron (Fe2+), zinc (Zn2+), copper (Cu2+) and manganese (Mn2+) in pomegranate leaves and roots. Mineral concentration of zinc (Zn2+), copper (Cu2+) and manganese (Mn2+) in roots and manganese (Mn2+) in shoot was increased with increasing salinity. Drought treatments decreased the concentration of Zn2+in the shoot and increased Zn2+in roots. Both cultivars showed significant differences in the Fe2+concentrations of shoot, however the most accumulation of Fe2+was observed in ‘Shishegap’ cultivar. [ABSTRACT FROM PUBLISHER]
- Published
- 2015
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4. Status of vaccination coverage in children 24 months to 6 years in urban and high risk areas covered by tehran university of medical sciences
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Nikfarjam, A., Ahmad Reza Shamshiri, Hasanpour, Z., and Khalili, M.
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vaccination converge ,children ,RC86-88.9 ,Medical emergencies. Critical care. Intensive care. First aid ,vaccination - Abstract
Background and Objectives: Children immunization program is one of the most successful and most cost-effective public health interventions and medical programs. The study was designed and conducted in order to assess the vaccination coverage in areas covered by Tehran University of Medical Sciences (TUMS). Methods: This study was a cross-sectional study of children aged 24 months to 6 years living in urban areas and high-risk and marginal areas covered by TUMS. Six hundred and thirty children were sampled in 90 clusters in urban areas and cluster sampling as probability proportional to size sampling was performed in high risk areas and a sample size of 768 children was determined. The questionnaires were completed by interview. Results: In high risk 750 children (97.7%, 95% CI: 96.32-98.60%) and 616 children (97.8%, 95% CI: 96.3-98.78%) in urban areas had complete immunization histories. Furthermore, 98.4% of the Iranian children and 95.0% of foreign children (P=0.019) in marginal areas and 98.1% of the Iranian children and 92.1% of the foreign children (P=0.046) in urban areas had complete immunization histories.Ignorance of immunization program (%50) was addressed as the main reason for incomplete immunization. Conclusion: Universal mass vaccination coverage of the children and equal coverage in marginal and urban areas indicated the success of the authorities in the implementation of this program. Organizing training courses for mothers on the immunization program, providing the required facilities and services, monitoring and supervision of vaccination and also considering the immunization status of foreign children seem to be essential in maintaining and improving the existing status.
5. Paradoxical effects of atorvastatin on renal tubular cells an experimental investigation
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Hasanpour, Z., Nasri, H., Rafieian-Kopaei, M., Ali Ahmadi, Baradaran, A., Nasri, P., and Nematbakhsh, M.
6. The Effect of Dextrose Hypotonic vs Saline Hydration on Methotrexate-Induced Nephrotoxicity in Male and Female Rats.
- Author
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Hasanpour Z, Choopani S, Ashrafi F, Talebi A, and Nematbaksh M
- Abstract
Background: High-dose methotrexate (HDMTX) as a cytotoxic agent might cause various side effects. Hyperhydration has been implemented as the major strategy to decrease the potential risk of toxicities induced by HDMTX. This study aims to assess the renoprotective effect of hydration with dextrose water (DW) 5% versus normal saline (N/S) 0.9% against methotrexate (MTX) induced nephrotoxicity., Materials and Methods: This experimental animal study has been conducted on 36 Wistar rats (200-250 g) categorized into six groups, including male ( n = 6) and female ( n = 6) rats receiving sodium chloride 0.9% saline plus MTX, DW 5% plus MTX, or MTX alone. By the fifth day after the MTX injection, biochemical indexes were measured. The rats were also sacrificed and renal specimens were evaluated microscopically to determine kidney tissue damage (KTD)., Results: The groups were not significantly different with regard to blood urea nitrogen (BUN) ( P = 0.5), creatinine (Cr) ( P = 0.24), kidney weight ( P = 0.34), and urine flow (UF) ( P = 0.5), while KTD score was remarkably less in the hydrated groups ( P < 0.001). Weight loss in DW-treated rats was significantly more than N/S-treated ones, and creatinine clearance (CrCl) and urine load (UL) of Cr were statistically similar between males and females in the control group, but significantly lower among the DW5% treated males., Conclusion: Based on the findings of this study, hydration with N/S was superior to DW5% for the prevention from HDMTX-induced nephrotoxicity. Besides, we found insignificant differences between male versus female rats in response to the hydration for HDMTX-induced renoprotection; however, females probably benefit more., Competing Interests: There are no conflicts of interest., (Copyright: © 2024 Advanced Biomedical Research.)
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- 2024
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7. Synthesis and pharmacological characterization of conformationally restricted 2-amino-Adipic acid analogs and carboxycyclopropyl glycines as selective metabotropic glutamate 2 receptor agonists.
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Staudt M, Liu N, Malhaire F, Doroudian Y, Prézeau L, Renard E, Hasanpour Z, Pin JP, and Bunch L
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- Rats, Animals, Glycine, Glutamic Acid pharmacology, Central Nervous System, Amino Acids pharmacology, Receptors, Metabotropic Glutamate agonists
- Abstract
The metabotropic glutamate (Glu) receptors (mGluRs) are G-protein coupled receptors, which play a central role in modulating excitatory neurotransmission in the central nervous system (CNS). Thus, the development of tool compounds thereto, continues to interest the scientific community. In this study, we report the design and synthesis of new conformationally restricted 2-aminoadipic acid (2AA) 2-4, and glutamic acid 5, 6 analogs, which share the cyclopropane ring as the restrictor. The analogs were characterized at rat mGlu1-8 in an IP-One functional assay. While the 2AA analogs 3a, 4a and CCG-I analog 5a were shown to be selective mGlu2 agonists with low micromolar potencies, CCG-II analog 5b was shown to be a potent full agonist at mGlu2 (EC
50 = 82 nM) with ∼15-fold selectivity over mGlu3, >25-fold selectivity over group III, and >60-fold selectivity over group I subtypes. An in silico study was performed to address this significant change (>3500 fold) in potency upon introduction of this methyl group (L-CCG-II vs 5b)., Competing Interests: Declaration of competing interest Lennart Bunch reports financial support was provided by University of Copenhagen. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)- Published
- 2024
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8. Effects of isochronal induced feed restriction during the transition period on mRNA abundance of the hepatic genes related to lipid metabolism in fat-tailed ewes.
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Hasanpour Z, Zarrin M, Oryan A, Mohaghegh-Dolatabad M, and Ahmadpour A
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- Animals, Energy Metabolism, Female, RNA, Messenger genetics, RNA, Messenger metabolism, Sheep genetics, Tail metabolism, Lipid Metabolism genetics, Liver
- Abstract
The process of fat mobilization during the transition period (TP) requires deep re-orchestration of the energy indices, and understanding its mechanism has generated considerable interest among the TP-related studies. The present study aims to validate the effect of feed restriction and TP on the mRNA abundance of hepatic genes related to fat metabolism in fat-tailed sheep. Twenty pregnant ewes with the age of 40.8 ± 6.2 (mean ± standard error) month were randomly assigned to control (n = 10) or restriction (n = 10), and investigated from week - 5 to 5 relative to parturition. Control animals received 100% DM during the trial. Restriction animals received 100% DM through weeks - 5, - 1, 1 and 5 and were fed with 50, 65, and 80% DM in the weeks - 4, - 3, - 2 and 2, 3, and 4, respectively. On the third week of experiment (65%) during both pre- and post-partum, the hepatic tissue was biopsied, and the mRNA load of the fatty acid synthase, acetyl-CoA carboxylase, carnitine palmitoyltransferase (CPT) 1, CPT2, and acyl-CoA synthase long-chain family member-1 genes was quantified by the TaqMan qPCR technique. Data were analyzed using the mixed model procedure of SAS. The mRNA abundance of the target genes was not influenced by feed restriction, during the pre- and post-partum periods. Parturition suppressed the mRNA abundance of target genes in both groups. It can be concluded that the fat-tailed sheep are well adapted to feed scarcity in the harsh environment and would have a higher capacity for the metabolism of fat mobilization during the negative energy balance., (© 2022. The Author(s), under exclusive licence to Springer Nature B.V.)
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- 2022
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9. Semi-Synthesis of New 1,2,3-Triazole Derivatives of 9-Bromonoscapine and their Anticancer Activities.
- Author
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Hasanpour Z, Salehi P, Bararjanian M, Esmaeili MA, Alilou M, and Mohebbi M
- Abstract
Novel 1,2,3-triazole-tethered 9-bromonoscapine derivatives were synthesized by the propargylation of N-nornoscapine followed by Huisgen's 1,3-dipolar cycloaddition of the terminal alkynes with different azides. Cytotoxicity of the products was studied by MTT assay against the MCF-7 breast cancer cell line. Most of the compounds revealed a better cytotoxicity than N-nornoscapine and 9-bromonornoscapine as the parent compounds. Among the synthesized compounds, those with a hydroxylated aliphatic side chain (5p, 5q, and 5r) showed the highest activities (IC50s: 47.2, 37.9, and 32.3 μg/mL, respectively). Molecular docking studies showed that these compounds also had the highest docking scores and effective interactions with binding sites equal to -8.074, -7.425 and -7.820 kcal/mol, respectively.
- Published
- 2021
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10. Healing effects of Pergularia tomentosa L., a native medicinal plant in Bushehr province, Iran on burn, in animal model.
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Farzadinia P, Mohebbi G, Bargahi A, Akbarzadeh S, Nabipour I, Abdi M, Hasanpour Z, Alipour Z, and Daneshi A
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- Administration, Cutaneous, Animals, Burns pathology, Dermatologic Agents isolation & purification, Disease Models, Animal, Iran, Male, Plant Extracts isolation & purification, Rats, Silver Sulfadiazine administration & dosage, Skin pathology, Time Factors, Apocynaceae chemistry, Apocynaceae growth & development, Burns drug therapy, Dermatologic Agents administration & dosage, Plant Extracts administration & dosage, Skin drug effects, Wound Healing drug effects
- Abstract
Burn injury is one of the most destructive events in the world. The Pergularia tomentosa L. is a medicinal plant that traditionally, applies for treatment of burning, in Bushehr province, Iran. Various bioactive compounds such as steroid glycosides, tannins, various vitamins, saponins, cardenolides and anthraquinones were identified into extract of the plant, which can be effective in burn wound healing. Twenty-one rats weighting every one 200±5 grams were divided equally into three groups. The second-degree burning induced on all groups. One of groups did not receive any treatment (The control group) and was treated locally with saline and eucerin. The Second group received the P. tomentosa L. as a topical ointment, and the third group received locally, a thin layer of silver sulfadiazine ointment 3% after washing the wound with saline. Afterward treatment period, the microscopic slides from histological sections were prepared. At that point, amounts of the fibroblast cells, blood vessels, wound area, necrotic tissues, and diameter of epidermis rate of wound healing were determined. Also the exterior status of wound in different days was considered. Results obtained from current study have revealed that the extract of P. tomentosa L. can significantly, cause qualitative and quantitative acceleration in healing of second degree burn wounds, due to their bioactive and vasoactive properties. In conclusion the P. tomentosa L. can is used as an overborne medicine with lower cost and side effect than the similar chemical medicines. Although, the further studies are needed on these plants, due to their some toxic effects.
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- 2019
11. Genetically engineered hairy root cultures of Hyoscyamus senecionis and H. muticus: ploidy as a promising parameter in the metabolic engineering of tropane alkaloids.
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Dehghan E, Reed DW, Covello PS, Hasanpour Z, Palazon J, Oksman-Caldentey KM, and Ahmadi FS
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- Biosynthetic Pathways genetics, Diploidy, Gene Expression Regulation, Plant, Genes, Plant genetics, Hyoscyamus classification, Hyoscyamus metabolism, Plant Roots metabolism, Plants, Genetically Modified, Scopolamine metabolism, Species Specificity, Tetraploidy, Tissue Culture Techniques, Alkaloids metabolism, Hyoscyamus genetics, Metabolic Engineering methods, Plant Roots genetics, Ploidies, Tropanes metabolism
- Abstract
Key Message: Tetraploidy improves overexpression of h6h and scopolamine production of H. muticus, while in H. senecionis, pmt overexpression and elicitation can be used as effective methods for increasing tropane alkaloids. The effects of metabolic engineering in a polyploid context were studied by overexpression of h6h in the tetraploid hairy root cultures of H. muticus. Flow cytometry analysis indicated genetic stability in the majority of the clones, while only a few clones showed genetic instability. Among all the diploid and tetraploid clones, the highest level of h6h transgene expression and scopolamine accumulation was interestingly observed in the tetraploid clones of H. muticus. Therefore, metabolic engineering of the tropane biosynthetic pathway in polyploids is suggested as a potential system for increasing the production of tropane alkaloids. Transgenic hairy root cultures of Hyoscyamus senecionis were also established. While overexpression of pmt in H. senecionis was correlated with a sharp increase in hyoscyamine production, the h6h-overexpressing clones were not able to accumulate higher levels of scopolamine than the leaves of intact plants. Applying methyl jasmonate was followed by a sharp increase in the expression of pmt and a drop in the expression of tropinone reductase II (trII) which consequently resulted in the higher biosynthesis of hyoscyamine and total alkaloids in H. senecionis.
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- 2017
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12. The effect of the various doses of atorvastatin on renal tubular cells; an experimental study.
- Author
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Nasri H, Hasanpour Z, Nematbakhsh M, Ahmadi A, and Rafieian-Kopaei M
- Abstract
Background: Recent retrospective observational studies suggest that high-potency statin therapy might increase the risk of acute kidney injury, however data on this subject is scares., Objectives: This study, was designed to investigate the renal tubular cell effect of different doses of atorvastatin to detect the possible aggravation of renal function or morphology of the kidney., Materials and Methods: In this experimental study 24 male Wistar rats were designated into 4 equal groups and treated as follows. Control group received phosphate buffer as the vehicle of atorvastatin for 7 days. Groups 1, II and III received atorvastatin at doses of 10, 50 and 150 mg/kg daily for 7 days, then on the day 8, all rats were anesthetized using ketamine and the blood samples were collected for evaluation of creatinine (Cr) and blood urea nitrogen (BUN) levels and then all rats were sacrificed, then the animals' kidneys were dissected out and histopathological studies were performed., Results: Mean (±SD) of scores of injury to renal tubular cells in control group was 4.2 ± 2.2 and in groups I, II and III were 6.44 ± 4.9, 15.4 ± 8.5 and 25.8 ± 12.7 respectively. Group III which received 150 mg/kg/day of atorvastatin had significant renal damage in comparison to control group (P < 0.001). There was no significant difference of renal injury score between control group with groups of I and II., Conclusions: In the present study we found, atorvastatin with a dose of 150 mg/kg/day for 7 days was nephrotoxic for rats, while lower doses at 10 mg/kg/day or 50 mg/kg/day for 7 days were not accompanied by renal injury. These findings imply further attention to the administration of higher doses of atorvastatin in clinical conditions.
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- 2016
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13. Association between serum myeloperoxidase levels and coronary artery disease in patients without diabetes, hypertension, obesity, and hyperlipidemia.
- Author
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Hasanpour Z, Javanmard SH, Gharaaty M, and Sadeghi M
- Abstract
Background: Myeloperoxidase (MPO) is an enzyme, elevated in the atheroma and serum of a patient with atherosclerotic vessels. The aim of this study is to investigate whether the serum MPO level is related to the presence of plaque in patients without risk factors, such as, diabetes, hypertension, obesity, and hyperlipidemia., Materials and Methods: A serum sample was collected from patients who referred for angiography. The MPO level was measured in the serum samples of 40 patients without risk factors for atherosclerosis using the enzyme-linked immunosorbent assay (ELISA)., Results: The MPO level was 245.5 ± 13.8 (ng/ml) in patients with atherosclerosis and 213.9 ± 8.9 (ng/ml) in patients without atherosclerosis. There was a significant difference between the groups (P = 0.002). The odds ratio was 0.67 (0.95 CI, 0.17 - 2.5) for patients with and without coronary atherosclerosis., Conclusion: Although the MPO concentration is higher in patients suffering from atherosclerosis, it is not a predictor of coronary artery disease in patients without diabetes, hypertension, obesity, and hyperlipidemia.
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- 2016
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14. Paradoxical effects of atorvastatin on renal tubular cells: an experimental investigation.
- Author
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Hasanpour Z, Nasri H, Rafieian-Kopaei M, Ahmadi A, Baradaran A, Nasri P, and Nematbakhsh M
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- Animals, Anticholesteremic Agents pharmacology, Blood Urea Nitrogen, Creatinine blood, Disease Models, Animal, Dose-Response Relationship, Drug, Gentamicins toxicity, Kidney injuries, Kidney Tubules cytology, Kidney Tubules pathology, Male, Rats, Rats, Wistar, Time Factors, Treatment Outcome, Atorvastatin pharmacology, Kidney drug effects, Kidney pathology, Kidney Tubules drug effects
- Abstract
Introduction: Atorvastatin has antioxidant activity and has been reported to increase blood antioxidant capacity. This study aimed to evaluate the effect of different doses of atorvastatin on gentamicin-induced kidney injury., Materials and Methods: In this experimental study, 30 male Wistar rats were designated into 6 equal groups for a 7-day period of intraperitoneal injections of gentamicin and atorvastatin. Group 1 received gentamicin, 80 mg/kg. Group 2 received phosphate buffer as the vehicle of atorvastatin. All rats in groups 3, 4, and 5 received gentamicin, 80 mg/kg/d, and then, after a 1-hour interval, atorvastatin was injected for 7 days as follow: group 3, 10 mg/kg/d; group 4, 50 mg/kg/d; and group 5, 150 mg/kg/d. Rats in group 6 received only 150 mg of atorvastatin. On the 8th day, blood samples were collected for evaluation of creatinine and blood urea nitrogen levels, and the animals' kidneys were dissected out for histopathological examinations., Results: Morphological damages to the tubular cells in groups 3 and 4 were less than those in groups 1 and 5. Injuries to the renal tubular cells in the rats of group 5 (gentamicin and atorvastatin, 150 mg/kg/d) and in group 6 (atorvastatin 150 mg/kg/d alone) were more extensive than those in group 1., Conclusions: The none-dose-dependent effect of atorvastatin in inducing renal tubular cell protection and renal tubular toxicity of atorvastatin in higher dose suggest administration of low-dose atorvastatin in critical conditions associated with renal tubular cell protection.
- Published
- 2015
15. Synthesis and anti-cholinesterase activity of new 7-hydroxycoumarin derivatives.
- Author
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Alipour M, Khoobi M, Moradi A, Nadri H, Homayouni Moghadam F, Emami S, Hasanpour Z, Foroumadi A, and Shafiee A
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- Acetylcholinesterase metabolism, Animals, Butyrylcholinesterase metabolism, Cell Death drug effects, Cholinesterase Inhibitors chemical synthesis, Cholinesterase Inhibitors chemistry, Dose-Response Relationship, Drug, Electrophorus, Horses, Hydrogen Peroxide antagonists & inhibitors, Hydrogen Peroxide pharmacology, Models, Molecular, Molecular Structure, PC12 Cells, Rats, Structure-Activity Relationship, Umbelliferones chemical synthesis, Umbelliferones chemistry, Cholinesterase Inhibitors pharmacology, Umbelliferones pharmacology
- Abstract
A series of 7-hydroxycoumarin derivatives connected by an amidic linker to the different amines were designed and synthesized as cholinesterase inhibitors. Most compounds showed remarkable inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Among them, N-(1-benzylpiperidin-4-yl)acetamide derivative 4r with IC50 value of 1.6 μM was the most potent compound against AChE. The selectivity index of compound 4r for anti-AChE activity was about 26. Moreover, the compound 4r significantly protected PC12 neurons against H2O2-induced cell death at low concentrations. The docking study of compound 4r with AChE enzyme showed that both CAS and PAS are occupied by the ligand., (Copyright © 2014 Elsevier Masson SAS. All rights reserved.)
- Published
- 2014
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16. Aqueous concentrations of VEGF and soluble VEGF receptor-1 in diabetic retinopathy patients.
- Author
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Javanmard SH, Hasanpour Z, Abbaspoor Z, Naderian GA, and Jahanmard M
- Abstract
Background: The aim of this study was to simultaneously measure the concentrations of vascular endothelial growth factor (VEGF) and soluble VEGF receptor-1 (sVEGFR-1, also known as sFlt-1) in the aqueous humor of patients with non-proliferative diabetic retinopathy (NPDR) and to investigate whether aqueous levels of vascular endothelial growth factor (VEGF) and VEGFR-1 are related to diabetic macular edema., Materials and Methods: Aqueous humor was collected from 27 diabetic patients and 33 age- and sex-matched normoglycemic controls and analyzed for pro-angiogenic VEGF and angiogenic inhibitor VEGFR-1 by enzyme-linked immunosorbent assay (ELISA). The mean foveal thickness was measured by optical coherence tomography (OCT)., Results: There was no significant difference in the aqueous levels of VEGF in patients with NPDR compared with control subjects (P > 0.05), while the NPDR patients had significantly lower sVEGFR-1 in their aqueous humor. Furthermore, a significant (P < 0.01) positive correlation was observed between VEGF/sVEGFR-1 concentration and the mean foveal thickness measured on OCT., Conclusion: The results suggest that decreased chelating effect of sVEGFR-1 may be the preliminary event allowing VEGF to activate the proangiogenic endothelial cell state and to induce permeability. The imbalance between angiogenic agent (VEGF) and the antiangiogenic factors (sFlt-1), which is disturbed in the diabetic state, may determine the fate of diabetic macular edema.
- Published
- 2012
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