109 results on '"Hasan Herken"'
Search Results
2. Evaluation of Oxidative Status in Patients Treated with Electroconvulsive Therapy
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Hasan Herken, Ali Korkmaz, Bunyamin Kaptanoglu, Hülya Aybek, and Mahmut Şenyurt
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neuroleptic agent ,medicine.medical_treatment ,antioxidant activity ,medicine.disease_cause ,electroconvulsive therapy ,Behavioral Neuroscience ,0302 clinical medicine ,Electroconvulsive therapy ,Total antioxidant status ,oxidative stress ,antidepressant agent ,Pharmacology (medical) ,Depression (differential diagnoses) ,bipolar disorder ,clinical article ,adult ,malonaldehyde ,aerobic metabolism ,Mood stabilizer ,biological marker ,Psychiatry and Mental health ,female ,Schizophrenia ,mood stabilizer ,blood sampling ,Original Article ,medicine.medical_specialty ,medicine.drug_class ,anxiolytic agent ,psychopharmacotherapy ,behavioral disciplines and activities ,Article ,smoking ,03 medical and health sciences ,male ,Internal medicine ,mental disorders ,medicine ,controlled study ,In patient ,human ,Bipolar disorder ,business.industry ,medicine.disease ,Oxidative stress index ,030227 psychiatry ,schizophrenia ,Total oxidant status ,major depression ,business ,030217 neurology & neurosurgery ,Oxidative stress ,trolox C ,Blood sampling - Abstract
Objective: Electroconvulsive therapy (ECT) is used in the treatment of many psychiatric diseases and this therapy may be effective on antioxidant defence system. In this study, we aimed to evaluate the effects of ECT on oxidative stress. Methods: Fourteen major depression, 11 schizophrenia and 8 bipolar affective disorder patients diagnosed and received ECT treatment, and 37 healthy volunteers enrolled in the study. ECT was applied to all patients. Before ECT, after the first and last ECTs, serum samples were obtained. Serum total antioxidant status (TAS), total oxidant status (TOS), and calculated oxidative stress index (OSI) were measured in patients before and after ECTs. Results: TOS values before ECT were higher in major depression (p=0.005) and schizophrenia (p=0.001) groups compared to the control group. TAS values were lower in major depression (p=0.0001), schizophrenia (p=0.004), bipolar affective disorder (p=0.004) groups compared to the controls. Also OSI values were higher in major depression (p=0.0001), schizophrenia (p=0.001), bipolar affective disorder (p=0.009) groups compared to healthy group. After the last ECT, TOS values were significantly lower compared to TOS values before ECT in major depression (p=0.004) and schizophrenia patients (p=0.004). TAS values after the first ECT were higher compared to values before ECT in major depression patients (p=0.004). After last ECT, OSI values were significantly lower compared to before ECT in schizophrenia patients (p=0.006). Conclusion: As a result, it can be said that ECT did not increase oxidative stress. However, further studies with more patients are needed. Copyright © 2017, Korean College of Neuropsychopharmacology.
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- 2017
3. Association of the Neuropeptide Y LEU7PRO rs16139 and NEUREXIN 3 rs760288 Polymorphisms with Alcohol Dependence
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Özlem İzci Ay, Ceyhan Balcı Şengül, Ahmet Buber, Mehmet Emin Erdal, Huseyin Alacam, Mustafa Ertan Ay, Cem Şengül, and Hasan Herken
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neuropeptide Y ,genetic association ,genotype ,Neurexin ,DNA determination ,gene frequency ,Biology ,Serotonergic ,Article ,neuropetide Y gene ,03 medical and health sciences ,0302 clinical medicine ,male ,single nucleotide polymorphism ,controlled study ,Pharmacology (medical) ,human ,Polymorphism ,gene ,DNA extraction ,Gene ,Genotyping ,neurexin 3 gene ,Genetics ,alcoholism ,integumentary system ,adult ,fungi ,Alcohol dependence ,Dopaminergic ,Neuropeptide Y receptor ,major clinical study ,030227 psychiatry ,SNP genotyping ,Psychiatry and Mental health ,female ,030217 neurology & neurosurgery - Abstract
Association of the Neuropeptide Y LEU7PRO rs16139 and NEUREXIN 3 rs760288 polymorphisms with alcohol dependence Objective: Alcoholism is associated with genetic variants of genes related to alcohol metabolizing enzymes, dopaminergic, gamma-aminobutyric acidergic, glutamatergic, opioid, cholinergic, and serotonergic systems. Neurpeptide Y system and Neurexins were shown to be associated with alcohol dependence. Recent studies identified new genetic polymorphisms related to endogenous cannabinoid system, neuropetide Y and neurexin. In the present study, we aimed to investigate the association of Neurpeptide Y LEU7PRO rs16139 and neurexin 3 gene rs760288 polymorphisms with alcohol dependence in patients with alcohol dependence and healthy control subjects. Methods: 123 patients who were diagnosed with alcohol dependence according to the DSM-IV criteria and 159 healthy volunteers were included in the study. Blood samples were used to investigate polymorphisms. The genotyping of the neurexin 3 gene rs760288 and the neuropetide Y gene Leu7Pro rs16139 polymorphisms was performed using TaqMan SNP Genotyping Assays Real-Time PCR System. Results: Of the 2 genetic polymorphisms investigated in the present study, we detected association between and neurexin 3 gene rs760288 polymorphisms with alcohol dependence. Conclusions: Neurexin gene polymorphisms might be an important factor in development of alcohol addiction.
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- 2016
4. Synapsin Polymorphisms Could Be Correlated with Stroop Simple Reaction Time Scores
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Ahmet Buber, Ömer Başay, Huseyin Alacam, Mehmet Emin Erdal, Kemal Utku Yazici, Hasan Herken, Burge Kabukcu Basay, Eyüp Sabri Ercan, Önder Öztürk, Ali Bacanlı, and Mustafa Ertan Ay
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Intelligence quotient ,business.industry ,Cognition ,CBCL ,medicine.disease ,behavioral disciplines and activities ,030227 psychiatry ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Rating scale ,mental disorders ,Medicine ,Attention deficit hyperactivity disorder ,Child Behavior Checklist ,business ,Neurocognitive ,030217 neurology & neurosurgery ,Clinical psychology ,Stroop effect - Abstract
Objective: The aim of this study was to research the relationship between Attention Deficit Hyperactivity Disorder (ADHD) and the synapsin III -196G>A and -631C>G polymorphisms and study their impact on neurocognition and behavior in Turkish children and adolescents. Methods: A total of 201 ADHD-diagnosed children and 100 control subjects aged between 8 and 15 years were recruited, and genetic material was obtained from saliva. In the diagnostic assessments, the KSADS- PL semi-structured interview was applied. Children with any comorbid psychiatric diagnosis (with the exclusion of oppositional defiant disorder (ODD)), medical conditions, prior psychotropic drug use history or IQ score below 80 were excluded. For the behavioral and ADHD symptom assessments, the Turgay DSM-IV Disruptive Behaviors Rating Scale, Teacher Report Form (TRF) and Child Behavior Checklist (CBCL) were completed by the parents and teachers. Neurocognitive profiles were evaluated with the CNS-Vital Signs computerized neurocognitive test battery. Results: No significant difference in ADHD prevalence was observed between subjects with the synapsin III gene -196G>A polymorphism and -631C>G polymorphisms. These polymorphisms were also not associated with subtypes of ADHD. We found a relationship between both polymorphisms and Stroop simple reaction time. Conclusion: Synapsin’s effect could be limited during childhood, but synapsin polymorphisms could be associated with Stroop simple reaction time.
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- 2016
5. Treatment response, safety, and tolerability of paliperidone extended release treatment in patients recently diagnosed with schizophrenia
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Marjolein Lahaye, Lars Helldin, Hasan Herken, Andreas Schreiner, Emilio Sacchetti, Roland Vauth, Joseph Peuskens, and Haye bij de Weg
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extended release ,flexible dosing ,paliperidone ,recent diagnosis ,schizophrenia ,Flexible dosing ,medicine.medical_specialty ,Treatment response ,business.industry ,Pharmacology ,medicine.disease ,Tolerability ,Schizophrenia ,Internal medicine ,medicine ,In patient ,Paliperidone ,Psychology (miscellaneous) ,Extended release ,business ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,Original Research ,medicine.drug - Abstract
Objective: This study was designed to explore the efficacy and tolerability of oral paliperidone extended release (ER) in a sample of patients who were switched to flexible doses within the crucial first 5 years after receiving a diagnosis of schizophrenia. Methods: Patients were recruited from 23 countries. Adults with nonacute but symptomatic schizophrenia, previously unsuccessfully treated with other oral antipsychotics, were transitioned to paliperidone ER (3–12 mg/day) and prospectively treated for up to 6 months. The primary efficacy outcome for patients switching for the main reason of lack of efficacy with their previous antipsychotic was at least 20% improvement in Positive and Negative Syndrome Scale (PANSS) total scores. For patients switching for other main reasons, such as lack of tolerability, compliance or ‘other’, the primary outcome was non-inferiority in efficacy compared with the previous oral antipsychotic. Results: For patients switching for the main reason of lack of efficacy, 63.1% achieved an improvement of at least 20% in PANSS total scores from baseline to endpoint. For each reason for switching other than lack of efficacy, efficacy maintenance after switching to paliperidone ER was confirmed. Statistically significant improvement in patient functioning from baseline to endpoint, as assessed by the Personal and Social Performance scale, was observed ( p < 0.0001). Treatment satisfaction with prior antipsychotic treatment at baseline was rated ‘good’ to ‘very good’ by 16.8% of patients, and at endpoint by 66.0% of patients treated with paliperidone ER. Paliperidone ER was generally well tolerated, with frequently reported treatment-emergent adverse events being insomnia, anxiety and somnolence. Conclusions: Flexibly dosed paliperidone ER was associated with clinically relevant symptomatic and functional improvement in recently diagnosed patients with non-acute schizophrenia previously unsuccessfully treated with other oral antipsychotics.
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- 2015
6. The impact of synapsin III gene on the neurometabolite level alterations after single-dose methylphenidate in attention-deficit hyperactivity disorder patients
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Mehmet Emin Erdal, Ahmet Buber, Ömer Başay, Yilmaz Kiroglu, Şenay Görücü Yılmaz, Huseyin Alacam, Hasan Herken, Önder Öztürk, and Burge Kabukcu Basay
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creatinine blood level ,methylphenidate ,Striatum ,chemistry.chemical_compound ,0302 clinical medicine ,N-acetylaspartate ,Adult ADHD ,single nucleotide polymorphism ,dose response ,Choline ,Original Research ,dorsolateral prefrontal cortex ,Methylphenidate ,adult ,drug effect ,creatinine ,single drug dose ,synapsin III gene ,medicine.anatomical_structure ,female ,Analysis of variance ,medicine.drug ,marker gene ,medicine.medical_specialty ,Neuropsychiatric Disease and Treatment ,Genotype ,cerebellum ,metabolite ,attention deficit disorder ,Creatine ,Article ,03 medical and health sciences ,male ,choline ,Internal medicine ,mental disorders ,Magnetic resonance spectroscopy ,medicine ,Attention deficit hyperactivity disorder ,human ,Psychiatry ,corpus striatum ,Anterior cingulate cortex ,anterior cingulate ,n acetylaspartic acid ,business.industry ,medicine.disease ,DNA isolation ,major clinical study ,030227 psychiatry ,Dorsolateral prefrontal cortex ,Endocrinology ,chemistry ,nervous system ,business ,030217 neurology & neurosurgery - Abstract
Ömer BaÅay,1 Burge Kabukcu Basay,1 Huseyin Alacam,2 Onder Ozturk,1 Ahmet Buber,1 Senay Gorucu Yilmaz,3 Yılmaz KıroÄlu,4 Mehmet Emin Erdal,5 Hasan Herken2 1Department of Child and Adolescent Psychiatry, Faculty of Medicine, Pamukkale University, Denizli, 2Department of Psychiatry, Faculty of Medicine, Pamukkale University, Denizli, 3Department of Nutrition and Dietetics, Faculty of Health Sciences, Gaziantep University, Gaziantep, 4Department of Radiology, School of Medicine, Pamukkale University, Denizli, 5Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin,Turkey Objective: To investigate the neurometabolite level changes according to synapsin III gene rs133945G>A and rs133946C>G polymorphisms by using magnetic resonance spectroscopy (MRS) in patients with attention-deficit hyperactivity disorder (ADHD).Methods: Fifty-seven adults diagnosed with ADHD were recruited for the study. The participants were examined by single-voxel 1H MRS when medication naïve and 30minutes after oral administration of 10mg methylphenidate (Mph). Those who had been on a stimulant discontinued the medication 48hours before MRS imaging. Spectra were taken from the anterior cingulate cortex, dorsolateral prefrontal cortex, striatum, and cerebellum, and N-acetylaspartate (NAA), choline, and creatine levels were examined. For genotyping of the synapsin III gene polymorphisms, DNA was isolated from peripheral blood leukocytes. The effects of age, sex, and ADHD subtypes were controlled in the analyses.Results: After a single dose of Mph, choline levels increased significantly in the striatum of rs133945G>A polymorphism-GG genotypes (P=0.020) and NAA levels rose in the anterior cingulate cortex of rs133946C>G polymorphism-CG genotypes (P=0.014). Both rs133945G>Aand rs133946C>G polymorphisms were found to statistically significantly affect the alteration of NAA levels in response to Mph in dorsolateral prefrontal cortex with two-way repeated measure of analysis of variance. Post hoc comparisons revealed a significant difference between CG and GG genotypes of rs133946C>G polymorphisms after Bonferroni adjustment (P=0.016).Conclusion: Synapsin III gene polymorphisms may be affecting the changes in neurometabolite levels in response to Mph in adult ADHD patients. Future studies are needed to confirm our findings. Keywords: adult ADHD, magnetic resonance spectroscopy, N-acetylaspartate, genotype
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- 2016
7. Relationship between Serum Bilirubin Levels and Metabolic Syndrome in Patients with Schizophrenia Spectrum Disorders
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Huseyin Alacam, Ceyhan Balcı Şengül, Kamuran Karakülah, Ozgur Kalkanci, Hasan Herken, Bunyamin Kaptanoglu, Yasar Enli, and Filiz Karadag
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neuroleptic agent ,medicine.medical_treatment ,cholesterol blood level ,insulin blood level ,morbidity ,030204 cardiovascular system & hematology ,bilirubin glucuronide ,Gastroenterology ,Behavioral Neuroscience ,chemistry.chemical_compound ,0302 clinical medicine ,high density lipoprotein cholesterol ,homeostasis model assessment ,insulin resistance ,Pharmacology (medical) ,glucose ,Prospective cohort study ,Abdominal obesity ,bilirubin blood level ,mental patient ,adult ,disease course ,correlational study ,blood pressure ,waist circumference ,Metabolic syndrome ,aged ,Psychiatry and Mental health ,female ,Original Article ,mets criteria ,triacylglycerol ,medicine.symptom ,diet restriction ,prospective study ,combination drug therapy ,insulin ,medicine.medical_specialty ,Waist ,Bilirubin ,030209 endocrinology & metabolism ,psychopharmacotherapy ,Article ,schizophrenia spectrum disorder ,abdominal obesity ,metabolic stability ,Atypical antipsychotics ,03 medical and health sciences ,Insulin resistance ,male ,Internal medicine ,medicine ,follow up ,controlled study ,diagnostic test accuracy study ,human ,naturalistic inquiry ,controlled clinical trial ,Triglyceride ,business.industry ,Insulin ,disease association ,medicine.disease ,major clinical study ,schizoaffective psychosis ,disease assessment ,schizophrenia ,glucose blood level ,chemistry ,Schizophrenia ,atypical antipsychotic agent ,metabolic syndrome X ,business - Abstract
Objective: We investigated the relationship between serum bilirubin levels and metabolic syndrome (MetS), and the longitudinal effects of baseline serum bilirubin concentrations on MetS in patients with schizophrenia spectrum disorders undergoing atypical antipsychotics. Methods: The sample of this study consisted of 131 patients with schizophrenia spectrum disorders. Waist circumference, blood pressure, and levels of triglycerides, high-density lipoprotein cholesterol, fasting glucose, and insulin were evaluated at baseline and at month six. Serum bilirubin levels were measured at baseline. Serum bilirubin levels of the patients with and without MetS criteria were compared. We also compared patients with high and low bilirubin levels (upper and lower 50th percentiles of serum bilirubin levels) in terms of MetS criteria, MetS frequency, and course of MetS. Results: Serum direct bilirubin levels were more consistently related to MetS and MetS-related variables. The waist circumference and triglyceride criteria for MetS were significantly related to low serum direct bilirubin at baseline; waist circumference and fasting glucose criteria, and insulin resistance were associated with low serum direct bilirubin at follow-up. MetS diagnosis and the presence of the waist circumference criterion were more frequent at the baseline and the follow-up in low bilirubin group. At the end of the follow-up period, the rate of reverse MetS was significantly higher in the high bilirubin group. Conclusion: Our results have suggested that serum direct bilirubin levels showed a more reliable and stable relationship with abdominal obesity for MetS components.in patients with schizophrenia spectrum disorders using antipsychotics. Further studies are required. Copyright © 2017, Korean College of Neuropsychopharmacology.
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- 2016
8. Association between dopamine beta hydroxylase gene polymorphism and age at onset in male schizophrenia
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Hasan Herken, Ayhan Algül, İbrahim Ömer Barlas, Mehmet Alpay Ates, Ümit Başar Semiz, Cengiz Basoglu, Özlem İzci Ay, Mehmet Emin Erdal, and Handan Çamdeviren
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onset age ,haplotype ,medicine.medical_specialty ,genetic association ,correlation analysis ,genotype ,sex difference ,medicine.medical_treatment ,Disease ,dopamine beta monooxygenase ,polymorphism ,male ,dopamine beta hydroxylase ,Dopamine ,Internal medicine ,Genotype ,medicine ,genetic polymorphism ,controlled study ,human ,Allele ,Antipsychotic ,Gene ,Biological Psychiatry ,Genetics ,clozapine ,adult ,male gender ,Haplotype ,article ,treatment response ,major clinical study ,schizophrenia ,Psychiatry and Mental health ,Endocrinology ,Gene polymorphism ,Psychology ,age at onset ,medicine.drug - Abstract
Objectives: The heterogeneity of schizophrenia mainly results from variations in clinical expressions of the disease, such as age at onset, gender differences in onset of illness, symptoms and response to antipsychotic treatment. Enhanced sensitisation of dopamine pathways in males, having consistently an earlier onset, might be implicated as disease modifiers for schizophrenia in males.Methods: In this study, we performed a case (n = 87)-control (n = 100) association study between the DBH5′-ins/del and DBH-444g/a polymorphisms of the DBH gene and also compared the level of psychotic symptoms between patients with different DBH genotypes/haplotypes with respect to antipsychotic therapeutic response and gender difference.Results: No significant differences between allele and genotype and haplotype frequencies at either groups (p < 0.05). When the age is considered in patient group, a significant difference was observed between patients with ID genotype and with II genotype (p = 0.018). Patients with ID genotype have been diagnosed as schizophrenics in early ages when compared to II genotype carriers. We also found a significant difference between II and ID genotype (p = 0.007) when the gender had taken into account, showing that the ID genotype carriers had an early onset to schizophrenia.Conclusions: This association was more significant in male schizophrenia patients than females. Thus, this finding may constitute a novel biological support for the prior finding that onset of schizophrenia varies with gender. The results also showed that critical genetic vulnerability may be associated with the presence or absence of the ID genotype of DBH5′-ins/del.
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- 2016
9. Effect of adult attention deficit hyperactivity symptoms on smoking cessation
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Ceyhan Balcı ŞENGÜL, Cem ŞENGÜL, GÜLŞEN ÜNLÜ, Ahmet BÜBER, Kamuran KARAKÜLAH, and Hasan HERKEN
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mental disorders ,Psikiyatri - Abstract
Objective: Nicotine addiction is the most prevalent addiction type all over the world and attention deficit hyperactivity disorder (ADHD) is an important factor associated with nicotine addiction. Primary aim of this study was to evaluate the effect of ADHD symptoms on smoking cessation. Methods: Smokers who had admitted to the smoking cessation center were evaluated with using Wender Utah and Fagerstorm Scales at the beginning of study and for the success of smoking cessation at the end of 6 months. Results: Of the 353 smokers enrolled to the study, 99 individuals had a score of 36 or higher on Wender Utah scale (ADHD symptoms group). Of these 99 patients with ADHD symptoms, 11 (11.1%) and of the 254 non-ADHD symptoms group, 68 (26.8%) had quitted smoking after a period of six months. Logistic regression analysis revealed that having ADHD symptoms predicted failure of smoking cessation (adjusted odds ratios 2.12, 95% confidence interval 1.02-4.40) after controlling for sociodemographic and smoking-related variables. Conclusions: ADHD symptoms may be an important factor affecting smoking cessation. Examining these symptoms in problematic nicotine addicts might help treatment outcome.
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- 2016
10. Mir-181B-5P, Mir-195-5P And Mir-301A-3P Are Related With Treatment Resistance In Schizophrenia
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Sakir Akgun, Hasan Herken, Huseyin Alacam, Burge Basay Kabukcu, Önder Öztürk, and Hakan Akca
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Male ,0301 basic medicine ,Oncology ,neuroleptic agent ,drug response ,Drug Resistance ,haloperidol ,MiR-181b-5p ,gene silencing ,0302 clinical medicine ,middle aged ,Haloperidol ,genetics ,chlorpromazine ,Genetics ,clinical article ,microRNA ,quantitative analysis ,adult ,Middle Aged ,unclassified drug ,receptor gene ,Reverse transcription polymerase chain reaction ,Psychiatry and Mental health ,female ,Real-time polymerase chain reaction ,priority journal ,real time polymerase chain reaction ,Schizophrenia ,blood sampling ,Female ,Antipsychotic Agents ,medicine.drug ,Adult ,medicine.medical_specialty ,microRNA 301 3p ,Treatment-resistant schizophrenia ,Real-Time Polymerase Chain Reaction ,Article ,reverse transcription polymerase chain reaction ,microRNA 181b 5p ,03 medical and health sciences ,microRNA 195 5p ,Internal medicine ,gene expression profiling ,medicine ,Humans ,Gene silencing ,controlled study ,MiR301a-3p ,human ,Gene Silencing ,outcome assessment ,Biological Psychiatry ,gene identification ,business.industry ,clinical effectiveness ,Gene Expression Profiling ,disease association ,case control study ,medicine.disease ,MiR-195-5p ,molecular dynamics ,drug efficacy ,schizophrenia ,Gene expression profiling ,MicroRNAs ,gene function ,030104 developmental biology ,Case-Control Studies ,gene expression ,business ,030217 neurology & neurosurgery ,Blood sampling - Abstract
The aim of the study was to determine the differences between expression levels of certain miRNAs, as their association with schizophrenia has been well presented in the literature, and to investigate their relation to treatment resistance in schizophrenic patients. Three groups were formed: 1) treatment resistant group, 2) treatment responsive group and 3) healthy control group. Expression levels of miRNAs from peripheric blood samples were determined by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). We investigated the roles of 29 schizophrenia-related miRNAs in schizophrenia treatment and their potentials to be considered as indicators. Among these miRNAs, only miR-181b-5p, miR-195-5p and miR-301a-3p expressions were found to be significantly different between the treatment-resistant group and the group responding well to the treatment miRNAs may cause resistance by silencing the receptor genes of the drugs used for schizophrenia treatment. miR-181b-5p, miR-195-5p and miR-301a-3p may be candidate indicators that can be used to reveal resistance against schizophrenia treatment. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
- Published
- 2016
11. Practice of Acute and Maintenance Electroconvulsive Therapy in the Psychiatric Clinic of a University Hospital from Turkey: Between 2007 and 2013
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Hasan Herken, Melike Ceyhan Balcı Şengül, Cem Şengül, Ayse Nur Inci Kenar, Ezgi Hanci, and İbrahim Sendur
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demography ,observation ,Hospitalized patients ,medicine.medical_treatment ,electroconvulsive therapy ,medical record review ,Turkey (republic) ,haloperidol ,Behavioral Neuroscience ,0302 clinical medicine ,Electroconvulsive therapy ,venlafaxine ,obsessive compulsive disorder ,Medicine ,Pharmacology (medical) ,psychosis ,Medical diagnosis ,chlorpromazine ,clomipramine ,bipolar depression ,clozapine ,sertraline ,Medical record ,adult ,duloxetine ,University hospital ,Psychiatry and Mental health ,hospital patient ,female ,Original Article ,paliperidone ,fluvoxamine ,paroxetine ,hospitalization ,medicine.medical_specialty ,olanzapine ,maintenance therapy ,mental hospital ,mood disorder ,university hospital ,behavioral disciplines and activities ,Article ,03 medical and health sciences ,milnacipran ,male ,Obsessive compulsive ,mental disorders ,controlled study ,human ,Psychiatry ,mirtazapine ,risperidone ,controlled clinical trial ,business.industry ,practice guideline ,Significant difference ,fluoxetine ,bipolar mania ,quetiapine ,Electroconvulsive therapy indications ,major clinical study ,schizoaffective psychosis ,030227 psychiatry ,social status ,schizophrenia ,age ,Male patient ,flupentixol ,catatonia ,disease duration ,business ,major depression ,Maintenance electroconvulsive therapy ,030217 neurology & neurosurgery - Abstract
Objective: Electroconvulsive therapy (ECT) can be given as the form of acute, continuation or maintenance ECT according to the process of administration. We report our 7 years' observation with acute and maintenance ECT in a university hospital in Turkey. Methods: The medical records of the hospitalized patients treated with acute or maintenance ECT between the years 2007 and 2013 was retrospectively analyzed. The sociodemographic characteristics, diagnosis, data of ECT and the co-administered psychotropic drugs were recorded. The frequency of ECT was calculated by identifying the total number of the hospitalized patients during the study period from the hospital records. Results: A total number of 1,432 female and 1,141 male patients hospitalized in a period of 7 years, with a total number of 111 patients treated with ECT. The ratio of ECT was 4%, maintenance/acute ECT 11%. For acute ECT, affective disorders (65.3%) and psychotic disorders (21.6%) were among the leading diagnoses. Maintenance ECT, the diagnosis was; 6 affective disorders, 4 psychotic disorders and 1 obsessive compulsive disorder. There was a significant difference between the patients receiving acute and maintenance ECT in terms of age, duration of illness, and number of previous hospitalizations and ECTs. Conclusion: The percentage of patients treated with acute ECT is lower in our institution than that in many other institutions from our country. Acute and maintenance ECT should be considered as an important treatment option particularly for patients with long disease duration, a high number of hospitalizations and a history of benefiting from previous ECTs. Copyright © 2016, Korean College of Neuropsychopharmacology.
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- 2016
12. Increased urinary 6-hydroxymelatoninsulfate levels in attention deficit hyperactivity disorder diagnosed children and adolescent
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Burcu Çakaloz, Gülşen Ünlü, Hayrani Eren Bostancı, Hülya Aybek, Hasan Herken, Yetis Isildar, Ahmet Buber, and [Buber, Ahmet -- Unlu, Gulsen] Pamukkale Univ, Fac Med, Dept Child & Adolescent Psychiat, Denizli, Turkey -- [Cakaloz, Burcu] Behcet Uz Childrens Hosp, Dept Child & Adolescent Psychiat, Izmir, Turkey -- [Isildar, Yetis] Sami Ulus Childrens Hosp, Dept Child & Adolescent Psychiat, Ankara, Turkey -- [Bostanci, Hayrani Eren] Cumhuriyet Univ, Fac Pharm, Dept Pharmaceut Basic Sci, Sivas, Turkey -- [Aybek, Hulya] Pamukkale Univ, Fac Med, Dept Biochem, Denizli, Turkey -- [Herken, Hasan] Pamukkale Univ, Fac Med, Dept Psychiat, Denizli, Turkey
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circadian rhythm ,Male ,medicine.medical_specialty ,Adolescent ,Urinary system ,attention deficit disorder ,melatonin ,Urine ,Gastroenterology ,6-sulfatoxymelatonin ,Excretion ,Melatonin ,Attention deficit hyperactivity disorder ,03 medical and health sciences ,0302 clinical medicine ,analogs and derivatives ,Internal medicine ,medicine ,Humans ,Circadian rhythm ,human ,child ,General Neuroscience ,Case-control study ,case control study ,medicine.disease ,Pathophysiology ,urine ,030227 psychiatry ,6-hydroxymelatoninsulfate ,Endocrinology ,female ,Attention Deficit Disorder with Hyperactivity ,Case-Control Studies ,Psychology ,030217 neurology & neurosurgery ,medicine.drug - Abstract
WOS: 000373539400033, PubMed ID: 26879834, There are some studies in attention deficit hyperactivity disorder (ADHD) which note altered circadian rhythms, suggesting abnormalities in melatonin physiology. In order to better characterize the possible melatonin alteration in ADHD, in this study we aimed to detect daytime, nighttime and 24 h levels of 6-hydroxymelatoninsulfate (6-OH MS) in the patients diagnosed with ADHD. Twenty-seven patients between 6 and 16 years-old, who had been diagnosed initially with ADHD, but without other physical and psychiatric disease history and who had not taken psychotropic pharmacotherapy for six months, plus 28 healthy volunteer controls, were included in the study. Urine samples were collected during the whole 24 h cycle, daytime and nighttime separately to assess the time-dependent excretion of the 6-OH MS, which is the main urine metabolite of melatonin. The Enzyme-Linked Immunosorbent Assay (ELISA) method was used for measuring the urine 6-OH MS level. Daytime (15.4 (8.9-24.8) ng/ml vs 6.9 (2.5-15.9) ng/ml, p = 0.002), nighttime (102.9 (65.3-197.7) ng/ml vs 61.5 (37.2-114.4) ng/ml, p = 0.012) and 24 h (54.1 (34.6-83.9) ng/ml vs 27.3 (14.3-48.9) ng/ml, p =0.000) 6-OH MS levels median (25p-75p) were found to be significantly higher in the ADHD group. After adjustment for age and sex, there was a statistically significant difference between the ADHD group (59.8 +/- 4.9) and control group (33.8 +/- 4.8) in 24-h 6-OH MS levels (F(1, 51) = 13.673, p = .001, partial eta 2 = .211). There was no relationship between 6-OH MS levels and Conners Parent Rating Scale short form subscale scores for the ADHD group. These findings indicate that melatonin production is increased in ADHD cases. Further research is needed to determine and thereby understand the mechanisms underlying the higher melatonin production, to assess the impact of altered melatonin on the pathophysiology of ADHD. (C) 2016 Elsevier Ireland Ltd. All rights reserved., Pamukkale University Scientific Research Projects Coordination Unit [TPF007], This research was supported by the Pamukkale University Scientific Research Projects Coordination Unit (TPF007). We thank Russel J. Reiter for his guidance from the beginning of the study.
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- 2016
13. White matter alterations related to attention-deficit hyperactivity disorder and COMT val158met polymorphism: Children with valine homozygote attention-deficit hyperactivity disorder have altered white matter connectivity in the right cingulum (cingulate gyrus)
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Önder Öztürk, Ömer Başay, Cengizhan Acikel, Mehmet Emin Erdal, Ahmet Buber, Hasan Herken, Huseyin Alacam, Kadir Agladioglu, Eyüp Sabri Ercan, Serkan Suren, Özlem İzci Ay, Burge Kabukcu Basay, and Ege Üniversitesi
- Subjects
Internal capsule ,genetic association ,brain development ,uncinate fasciculus ,capsula interna ,0302 clinical medicine ,Gyrus ,Polymorphism (computer science) ,Attention deficit ,valine ,Cingulum (brain) ,genetic polymorphism ,Original Research ,child ,cingulate gyrus ,connectome ,diffusion tensor imaging ,unclassified drug ,homozygote ,medicine.anatomical_structure ,female ,white matter ,fractional anisotropy ,RC321-571 ,medicine.medical_specialty ,Neuropsychiatric Disease and Treatment ,Catechol-O-methyltransferase ,sex difference ,attention deficit disorder ,Neurosciences. Biological psychiatry. Neuropsychiatry ,Neuroimaging ,behavioral disciplines and activities ,Article ,White matter ,03 medical and health sciences ,male ,corona radiata (brain) ,Internal medicine ,mental disorders ,Fractional anisotropy ,medicine ,Attention deficit hyperactivity disorder ,controlled study ,human ,RC346-429 ,methionine ,Catechol-O-methyl transferase ,business.industry ,medicine.disease ,major clinical study ,Hyperactivity ,030227 psychiatry ,thalamus posterior nucleus ,Endocrinology ,catechol methyltransferase ,age ,adolescent ,Neurology. Diseases of the nervous system ,COMT gene ,intelligence quotient ,business ,030217 neurology & neurosurgery - Abstract
WOS: 000374501400001, PubMed ID: 27143897, Introduction: In this article, the COMT gene val(158)met polymorphism and attention-deficit hyperactivity disorder (ADHD)-related differences in diffusion-tensor-imaging-measured white matter (WM) structure in children with ADHD and controls were investigated. Patients and methods: A total of 71 children diagnosed with ADHD and 24 controls aged 8-15 years were recruited. Using diffusion tensor imaging, COMT polymorphism and ADHD-related WM alterations were investigated, and any interaction effect between the COMT polymorphism and ADHD was also examined. The effects of age, sex, and estimated total IQ were controlled by multivariate analysis of covariance (MANCOVA). Results: First, an interaction between the COMT val(158)met polymorphism and ADHD in the right (R) cingulum (cingulate gyrus) (CGC) was found. According to this, valine (val) homozygote ADHD-diagnosed children had significantly lower fractional anisotropy (FA) and higher radial diffusivity (RD) in the R-CGC than ADHD-diagnosed methionine (met) carriers, and val homozygote controls had higher FA and lower RD in the R-CGC than val homozygote ADHD patients. Second, met carriers had higher FA and axial diffusivity in the left (L)-uncinate fasciculus and lower RD in the L-posterior corona radiata and L-posterior thalamic radiation (include optic radiation) than the val homozygotes, independent of ADHD diagnosis. Third, children with ADHD had lower FA in the L-CGC and R-retrolenticular part of the internal capsule than the controls, independent of the COMT polymorphism. Conclusion: Significant differences reported here may be evidence that the COMT gene val(158)met polymorphism variants, as well as ADHD, could affect brain development. ADHD and the COMT polymorphism might be interactively affecting WM development in the R-CGC to alter the WM connectivity in children with val homozygote ADHD.
- Published
- 2016
14. Catechol-O-methyltransferase gene Val108/158Met polymorphism in bipolar disorder
- Author
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Tuba Gokdogan, Mehmet Yumru, Mehmet Emin Erdal, Hasan Herken, I. Ömer Barlas, Murat Eren Özen, Haluk A. Savaş, and Osman Virit
- Subjects
medicine.medical_specialty ,business.industry ,General Neuroscience ,medicine.disease ,law.invention ,Psychiatry and Mental health ,Endocrinology ,Polymorphism (computer science) ,law ,Catechol-O-Methyltransferase Gene ,Internal medicine ,Genotype ,medicine ,Comt gene ,Neurology (clinical) ,Bipolar disorder ,Allele ,Psychiatry ,business ,Gene ,Polymerase chain reaction - Abstract
Backgrounds Although several studies have tested the association between bipolar disorder (BD) and the Val108 (H, high-activity allele)/158Met (L, low-activity allele) polymorphism of the catechol-O-methyltransferase (COMT) gene, most of the results showed no significant association. However, an association between the H or L allele and bipolar disorder (BD), particularly, between L allele and rapid-cycling form has been reported; it has also been suggested that the variation in the COMT gene modifies the course of BD and there is a tendency for the L allele amongst the female patients. In this study, the researchers aimed to evaluate the association between BD and COMT gene H/L polymorphism considering the influence of gender in a group of Turkish patients. Method One hundred and thirty-five BD patients (71 male and 64 female) and 171 controls were included. Polymerase chain reaction-based endonuclease digestion method was used. Results Genotypic distribution in patients and controls were in Hardy–Weinberg equilibrium. No significant difference was found in genotypic and allelic frequencies between patients and controls. However, female patients had H allele more frequently than male patients and female healthy controls. Females had more depressive and less manic episodes than males. Number of total episodes was associated with H allele in all patients. Conclusion Distribution of COMT genetic polymorphism was not significantly different between the patients and controls. However, it has been found an association of H allele with female patients and number of episodes among all patients.
- Published
- 2011
15. Katekol-O-metiltransferaz geni Val158Met polimorfizminin şizofreni hastalarındaki bilişsel işlevlere etkileri / Effects of catechol-O-methyltransferase enzyme Val158Met polymorphism on cognitive functions in schizophrenic patients
- Author
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Tuba Gokdogan, M. Emin Erdal, Gülfizar Sözeri Varma, Filiz Karadag, Hasan Herken, Özlem İzci Ay, Çiğdem Tekkanat, and Neslihan Levent
- Subjects
chemistry.chemical_classification ,Psychiatry and Mental health ,Enzyme ,Catechol-O-methyl transferase ,chemistry ,Polymorphism (computer science) ,business.industry ,Medicine ,Pharmacology (medical) ,business ,Molecular biology - Published
- 2011
16. Is the dopamine D3 receptor mRNA on blood lymphocytes help to for identification and subtyping of schizophrenia?
- Author
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Seval Kul, M. Urhan-Kucuk, Mehmet Emin Erdal, Hasan Herken, and Murat Eren Özen
- Subjects
disease marker ,PBL ,genetics ,Lymphocytes ,primer DNA ,Receptor ,messenger RNA ,Reverse Transcriptase Polymerase Chain Reaction ,adult ,article ,General Medicine ,RNA analysis ,RNA isolation ,female ,Real-time polymerase chain reaction ,classification ,Dopamine receptor ,Schizophrenia ,DRD3 mRNA ,disease severity ,medicine.drug ,diagnostic agent ,RT-PCR ,lymphocyte ,Biology ,Statistics, Nonparametric ,reverse transcription polymerase chain reaction ,male ,Dopamine receptor D3 ,Dopamine ,nonparametric test ,Genetics ,medicine ,Humans ,controlled study ,human ,RNA, Messenger ,Molecular Biology ,DNA Primers ,Messenger RNA ,human cell ,Receptors, Dopamine D3 ,medicine.disease ,major clinical study ,Reverse transcriptase ,dopamine 3 receptor ,schizophrenia ,Immunology ,metabolism - Abstract
Schizophrenia is one of the neuropathological disorders, which are associated with dopamine and its receptors. In recent years, it has been shown that mRNA of D3, D4 and D5 dopamine receptor (DRD3, DRD4, DRD5) subtypes is expressed in human peripheral blood lymphocytes (PBL). A total 55 schizophrenic patients and 51 healthy subjects were included in the study to investigate the levels of DRD3 mRNA in PBL of schizophrenic patients and whether DRD3 mRNA level in PBL can serve as peripheral marker for schizophrenia. RNA was isolated from lymphocytes of both groups and reverse transcriptase polymerase chain reaction (RT-PCR) was performed for DRD3 mRNA. We found a significant difference in PBL DRD3 mRNA levels among schizophrenia subtypes (P = 0.030) while no difference was detected between control subjects and schizophrenics. We concluded that the levels of DRD3 mRNA can help understanding and severity of clinical manifestations in schizophrenia. © Springer Science+Business Media B.V. 2010.
- Published
- 2010
17. Lack of association between DRD3 gene polymorphism and response to clozapine in Turkish schizoprenia patients
- Author
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Ümit Başar Semiz, Cengiz Basoglu, I. Ömer Barlas, M. Emin Erdal, Hasan Herken, M. Ertan Ay, Mesut Cetin, and Özcan Uzun
- Subjects
Turkey ,genotype ,medicine.medical_treatment ,Glycine ,Biology ,Pharmacology ,Bioinformatics ,behavioral disciplines and activities ,Association ,Cellular and Molecular Neuroscience ,Limbic system ,male ,Dopamine receptor D3 ,Genotype ,Serine ,medicine ,controlled study ,human ,Polymorphism ,Antipsychotic ,DNA extraction ,Clozapine ,Gene ,Genetics (clinical) ,DNA Primers ,Dopamine D3 receptor gene (DRD3) ,Polymorphism, Genetic ,Base Sequence ,adult ,Dopaminergic ,article ,Receptors, Dopamine D3 ,treatment response ,major clinical study ,Psychiatry and Mental health ,female ,medicine.anatomical_structure ,priority journal ,DNA polymorphism ,Case-Control Studies ,Schizophrenia ,Gene polymorphism ,psychologic assessment ,Antipsychotic Agents ,medicine.drug - Abstract
It is hypothesized that molecular components of dopaminergic system, especially the dopamine D3 receptor gene (DRD3), may play a crucial role in the pathophysiology of schizophrenia, because it is abundant in the limbic system of the brain and it binds antipsychotic drugs. Several groups attempted to find an association between a serine-to-glycine polymorphism of the DRD3 gene (Ser9Gly) and schizophrenia; however, the results were inconsistent. In this study, we aimed to investigate the relationship of the Serine/Glycine polymorphism of the DRD3 gene with therapeutic response to clozapine treatment between Turkish schizophrenia patients (N = 92) and healthy controls (N = 100). Genotype groups were comparable in BPRS, SAPS, SANS analysis of response to clozapine. Our results suggest that an association between the Ser/Gly polymorphism of DRD3 gene and response to clozapine in Turkish schizophrenia patients is unlikely to exist. © 2008 Wiley-Liss, Inc.
- Published
- 2009
18. Association of MDR1 C3435T polymorphism with bipolar disorder in patients treated with valproic acid
- Author
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Hasan Herken, Erhan Kurt, Timucin Oral, Cem Şengül, Günfer Turgut, Gazi Alatas, Raziye Kursunluoglu, and S. Turgut
- Subjects
Adult ,Male ,medicine.medical_specialty ,Bipolar Disorder ,Adolescent ,MDR1 ,ATP-binding cassette transporter ,Pharmacology ,Biology ,Polymorphism, Single Nucleotide ,Gastroenterology ,Cytosine ,Exon ,Internal medicine ,Genotype ,Genetics ,medicine ,Humans ,ATP Binding Cassette Transporter, Subfamily B, Member 1 ,Bipolar disorder ,Allele ,Molecular Biology ,Aged ,Genetic association ,Valproic Acid ,Genetic polymorphism ,P-Glycoprotein ,General Medicine ,Middle Aged ,medicine.disease ,Pharmacogenomics ,Female ,ATP Binding Cassette Transporter, Subfamily B, Member 1/*genetics/metabolism ,Bipolar Disorder/*drug therapy/*genetics/metabolism ,Cytosine/metabolism ,Polymorphism, Single Nucleotide/*genetics ,Valproic Acid/*therapeutic use ,medicine.drug - Abstract
P-glycoprotein (P-gp), an efflux transporter protein, is an ABC transporter encoded by the multidrug resistance 1 gene (MDR1, ABCB1). The common synonymous C3435T polymorphism in exon 26 is reported to associate with lower P-gp functional expression and drug uptake. Many extended pharmacogenomics, functional, and complex disease association studies focused mainly on this polymorphism. We investigated the association of exon 26 C3435T genetic variants of MDR1 gene with susceptibility to bipolar disorder and serum valproic acid concentration. Totally, 104 patients meeting DSM-IV criteria for bipolar disorder and 169 controls were admitted to the study. There was statistically significant difference between the genotypes of bipolar patients (CT 91.2%, TT 6.8%, and CC 2%) and controls (CT 52.7%, TT 26%, CC 21.3%) although their allelic distribution was similar. The serum valproic acid concentrations of the patients with CT, TT and CC genotypes were 72.92 ± 20.55, 80.47 ± 14.01 and 68.29 ± 12.17 µg/ml, respectively, and there was no significant difference between the C3435T genotypes. © 2007 Springer Science+Business Media B.V.
- Published
- 2007
19. Clinical predictors of therapeutic response to clozapine in a sample of Turkish patients with treatment-resistant schizophrenia
- Author
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Ayhan Algül, Hakan Balibey, Ümit Başar Semiz, Özcan Uzun, Mesut Cetin, Cengiz Basoglu, Hasan Herken, Alpay Ates, and Servet Ebrinç
- Subjects
Male ,Turkey ,medicine.medical_treatment ,Drug Resistance ,Turkey (republic) ,negative syndrome ,positive syndrome ,Brief Psychiatric Rating Scale ,Clozapine ,scale for the assessment of negative symptoms ,drug effect ,article ,weight gain ,Middle Aged ,female ,Treatment Outcome ,Clozapine response ,Schizophrenia ,Female ,Psychology ,Antipsychotic Agents ,medicine.drug ,Psychopathology ,drug dose increase ,Adult ,medicine.medical_specialty ,Psychosis ,side effect ,Treatment-resistant schizophrenia ,open study ,Internal medicine ,scale for the assessment for positive symptoms ,medicine ,Humans ,human ,Psychiatry ,Antipsychotic ,Scale for the Assessment of Negative Symptoms ,Biological Psychiatry ,Probability ,Psychiatric Status Rating Scales ,Pharmacology ,treatment response ,prediction ,medicine.disease ,major clinical study ,schizophrenia ,Clinical trial ,Logistic Models ,Predictor ,rating scale - Abstract
Background: Several lines of evidence suggest that clozapine is more effective than both first- and second-generation antipsychotic drugs in treatment-resistant schizophrenia (TRS). However, clinicians appear to be hesitant to prescribe this drug. It would therefore be extremely valuable if predictors of response to clozapine could be identified. The aim of this study was to evaluate the predictive factors of clinical responses to clozapine in a group of Turkish patients with TRS. Methods: This was a 16-week uncontrolled open study carried out among 97 TRS patients (80 males and 17 females; DSM-IV diagnosis). All patients fulfilled the criteria for refractory schizophrenia according to the UK guidelines for the National Institute of Clinical Excellence (NICE). After all previous antipsychotic medications had run their course, the patients were started on clozapine according to a standardized titration and dosage schedule. Psychopathology was evaluated before the initiation of clozapine therapy and once every 4 weeks using the Brief Psychiatric Rating Scale (BPRS), the Scale for the Assessment for Positive Symptoms, and the Scale for the Assessment of Negative Symptoms. Results: Of the TRS patients on clozapine, 55.7% achieved a clinical response, defined as at least a 20% decrease in BPRS. We observed a favorable effect of clozapine on both positive and negative symptoms. Logistic regression analysis showed that a good clozapine response was more likely when schizophrenia began at a later age, when negative symptoms were severe, and when patients had an early response at 4 weeks. Conclusion: A combination of demographic, baseline clinical, and acute treatment response variables may accurately predict response to clozapine in TRS. Priority should be given to initiating clozapine at the earliest phase of TRS, especially for patients with evident negative symptoms. © 2007 Elsevier Inc. All rights reserved.
- Published
- 2007
20. Adenosine Deaminase, Nitric Oxide, Superoxide Dismutase, and Xanthine Oxidase in Patients with Major Depression: Impact of Antidepressant Treatment
- Author
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Ozlem Kap, Omer Akyol, Salih Selek, Mahmut Bulut, Haluk A. Savaş, Hasan Herken, Ferah Armutcu, Ahmet Gürel, Murat Eren Özen, Mehmet Yumru, and Zonguldak Bülent Ecevit Üniversitesi
- Subjects
Male ,Antidepressant ,chemistry.chemical_compound ,Adenosine deaminase ,antidepressant agent ,citalopram ,Xanthine oxidase ,pathophysiology ,Depression (differential diagnoses) ,chemistry.chemical_classification ,clinical article ,biology ,sertraline ,Depression ,article ,General Medicine ,Middle Aged ,Prognosis ,Antidepressive Agents ,Pathophysiology ,enzyme activity ,female ,Hamilton scale ,fluvoxamine ,diagnostic and statistical manual of mental disorders ,Adult ,medicine.medical_specialty ,Adolescent ,Superoxide dismutase ,oxygen radical ,Nitric oxide ,enzyme blood level ,Internal medicine ,medicine ,Humans ,controlled study ,human ,Depressive Disorder, Major ,business.industry ,fluoxetine ,monitoring ,Enzyme ,Endocrinology ,chemistry ,serotonin uptake inhibitor ,treatment outcome ,biology.protein ,major depression ,business - Abstract
Background: There has been much evidence in recent years that free oxygen radicals and nitric oxide (NO) may play an important role in the pathophysiology of neuropsychiatric disorders. In this study, we aimed to investigate whether NO, xanthine oxidase (XO), superoxide dismutase (SOD), and adenosine deaminase (ADA) levels are associated with major depression (MD) and to evaluate the impact of antidepressant treatments on NO, SOD, ADA and XO levels in MD. Methods: Thirty-six patients who were diagnosed as MD according to DSM-IV criteria and 20 healthy controls were included. The serum levels of NO, XO, SOD, and ADA were measured by spectrophotometric methods both in patients and controls. Patients were treated with antidepressant drugs for 8 weeks. All patients were assessed by Hamilton Depression Rating Scale (HDRS) both before and after antidepressant treatment. Results: ADA and XO levels of the patients were significantly higher than the controls. SOD level of the patients was significantly lower than the controls. Although NO levels of the patients were higher than the controls, the difference was not statistically significant. There was no correlation between HDRS and the parameters studied (SOD, ADA, XO, and NO) of the patients. After 8 weeks of antidepressant treatment, ADA and SOD activities were increased, whereas NO and, XO levels decreased significantly. Conclusions: ADA, XO, and SOD activity may have a pathophysiological role in MD and may predict prognosis of MD. Activity of these enzymes may be used to monitor effects of the antidepressant treatment. © 2007 IMSS.
- Published
- 2007
21. Increased Levels of Nitric Oxide, Cortisol and Adrenomedullin in Patients with Chronic Schizophrenia
- Author
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Muhittin Yürekli, Ahmet Celik, Hulya Cicek, Hasan Herken, Omer Akyol, Necat Yilmaz, and Biyokimya
- Subjects
Adult ,Male ,endocrine system ,medicine.medical_specialty ,Hydrocortisone ,Nitric Oxide ,Statistics, Nonparametric ,Nitric oxide ,Adrenomedullin ,chemistry.chemical_compound ,Dehydroepiandrosterone sulfate ,General & Internal Medicine ,Internal medicine ,Humans ,Medicine ,In patient ,Chromatography, High Pressure Liquid ,business.industry ,Case-control study ,Dehydroepiandrosterone ,General Medicine ,medicine.disease ,Endocrinology ,chemistry ,Schizophrenia ,Case-Control Studies ,Chronic Disease ,Chronic schizophrenia ,business ,hormones, hormone substitutes, and hormone antagonists ,Serum cortisol - Abstract
Objective: To investigate the levels of serum cortisol, dehydroepiandrosterone sulfate (DHEA-S), nitric oxide (NO) and adrenomedullin (AM) in schizophrenic patients. Subjects and Methods: Sixty-six male patients with chronic schizophrenia and 28 normal male subjects participated in this study. The duration of disease was 145 ± 120 (mean ± SD) months. Serum levels of cortisol and DHEA-S were measured by electrochemiluminescence; plasma nitrite levels as an index of NO were measured with the Griess reaction, while plasma AM concentration was measured by using high-performance liquid chromatography. Results: Patients (12.48 ± 3.2 µg/dl), as compared to controls (10.31 ± 3.1 µg/dl), had higher levels of baseline cortisol (p < 0.05). DHEA-S levels were lower in patients though this did not reach statistical significance (302 ± 156 µg/dl compared to control, 322 ± 96 µg/dl, p > 0.05). The mean levels of plasma AM and NO in the schizophrenic group (44.33 ± 5.07 pmol/l and 36.27 ± 17.6 µmol/l) were significantly higher than the levels in the control group (14.56 ± 4.03 pmol/l and 32.54 ± 7.14 µmol/l; p < 0.001, p < 0.03, respectively). There was a positive association between duration of disease and cortisol/DHEA-S ratio and cortisol level. Conclusion: The data show that schizophrenia is associated with abnormal levels of cortisol, DHEA-S, NO and AM.
- Published
- 2007
22. The protective effects of omega−3 fatty acids against MK-801-induced neurotoxicity in prefrontal cortex of rat
- Author
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Birsen Ozyurt, Mustafa Sarsilmaz, Huseyin Ozyurt, Ilter Kus, Omer Akyol, Hasan Herken, and Nusret Akpolat
- Subjects
Male ,carbonyl derivative ,Apoptosis ,animal cell ,Protein oxidation ,medicine.disease_cause ,Prefrontal cortex ,Lipid peroxidation ,chemistry.chemical_compound ,dizocilpine ,Malondialdehyde ,decapitation ,neurotoxicity ,oxidative stress ,rat ,psychosis ,rat strain ,glutathione peroxidase ,statistical significance ,experimental animal ,chemistry.chemical_classification ,MK-801 ,oxidation kinetics ,Glutathione peroxidase ,catalase ,malonaldehyde ,article ,marincap ,lipid peroxidation ,docosahexaenoic acid ,superoxide dismutase ,enzyme activity ,priority journal ,Biochemistry ,diet supplementation ,Docosahexaenoic acid ,microscopy ,neuroprotection ,Protein carbonyl ,medicine.medical_specialty ,animal experiment ,neurochemistry ,omega 3 fatty acid ,Biology ,animal tissue ,histology ,Superoxide dismutase ,Cellular and Molecular Neuroscience ,icosapentaenoic acid ,nitric oxide ,Internal medicine ,drug mechanism ,medicine ,Animals ,controlled study ,Unsaturated fatty acid ,neuropathology ,nonhuman ,Omega - 3 fatty acids ,animal model ,Cell Biology ,adenosine deaminase ,Rats ,schizophrenia ,Endocrinology ,chemistry ,biology.protein ,prognosis ,neurophysiology ,Dizocilpine Maleate ,xanthine oxidase ,Oxidative stress - Abstract
The aims of this study are to investigate the contribution effect of oxidative stress in MK-801-induced experimental psychosis model, and to show that prevention of oxidative stress may improve prognosis. Because oxidative damage has been suggested in the neuropathophysiology of schizophrenia, the possible protecting agents against lipid peroxidation are potential target for the studies in this field. For this purpose, Wistar Albino rats were divided into three groups: the first group was used as control, MK-801 was given to the rats in the second group and MK-801 + ω - 3 essential fatty acids (EFA) was given to the third group. MK-801 was given intraperitoneally at the dose of 0.5 mg/(kg day) once a day for 5 days in experimental psychosis group. In the second group, 0.8 g/(kg day), ω - 3 FA (eicosapentaenoic acid, 18%, docosahexaenoic acid, 12%) was given to the rats while exposed MK-801. In control group, saline was given intraperitoneally at the same time. After 7 days, rats were killed by decapitation. Prefrontal brain area was removed for histological and biochemical analyses. As a result, malondialdehyde (MDA), as an indicator of lipid peroxidation, protein carbonyl (PC), as an indicator of protein oxidation, nitric oxide (NO) levels and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activities as antioxidant enzymes, and xanthine oxidase (XO) and adenosine deaminase (AD) activities as an indicator of DNA oxidation was found to be increased significantly in prefrontal cortex (PFC) of MK-801 group (P < 0.0001) compared to control group. In ω - 3 FA treated rats, prefrontal tissue MDA, PC and NO levels as well as SOD, GSH-Px, XO, and AD enzyme activities were significantly decreased when compared to MK-801 groups (P < 0.0001) whereas catalase (CAT) enzyme activity was not changed. Moreover, in the light of microscopic examination of MK-801 groups, a great number of apoptotic cells were observed. ω - 3 FA supplementation decreased the apoptotic cell count in PFC. The results of this study revealed that oxidative stress and apoptotic changes in PFC may play an important role in the pathogenesis of MK-801-induced neuronal toxicity. This experimental study also provides some evidences for the protective effects of ω - 3 FA on MK-801-induced changes in PFC of rats. © 2006.
- Published
- 2007
23. Association of adult attention deficit hyperactivity disorder subtypes and response to methylphenidate HCL treatment: A magnetic resonance spectroscopy study
- Author
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Yilmaz Kiroglu, Ayse Nur Inci Kenar, Hasan Herken, and G.A. Unal
- Subjects
Male ,Magnetic Resonance Spectroscopy ,Subtype ,methylphenidate ,Striatum ,Choline ,chemistry.chemical_compound ,N-acetylaspartate ,analogs and derivatives ,Adult ADHD ,Cerebellum ,middle aged ,central stimulant agent ,Prefrontal cortex ,dorsolateral prefrontal cortex ,prefrontal cortex ,Methylphenidate ,General Neuroscience ,adult ,cingulate gyrus ,drug effect ,medicine.anatomical_structure ,female ,priority journal ,nuclear magnetic resonance scanner ,young adult ,Psychology ,medicine.drug ,medicine.medical_specialty ,Adolescent ,metabolite ,attention deficit disorder ,Creatine ,Gyrus Cinguli ,Article ,Internal medicine ,mental disorders ,medicine ,Attention deficit hyperactivity disorder ,Humans ,human ,corpus striatum ,Anterior cingulate cortex ,nuclear magnetic resonance spectroscopy ,anterior cingulate ,Aspartic Acid ,n acetylaspartic acid ,treatment response ,medicine.disease ,major clinical study ,Dorsolateral prefrontal cortex ,Endocrinology ,chemistry ,Attention Deficit Disorder with Hyperactivity ,Central Nervous System Stimulants ,Neuroscience ,human activities ,metabolism - Abstract
The effects of methylphenidate (MPH) treatment on N-acetyl aspartate (NAA), choline and creatine are being examined in individuals with different subtypes of attention deficit hyperactivity disorder (ADHD). Sixty ADHD subjects were included into the study aging between 18 and 60 years. Levels of NAA, creatine and choline in anterior cingulate cortex, cerebellum, striatum and dorsolateral prefrontal cortex were measured with magnetic resonance spectroscopy. Then, 10 mg oral MPH was given to the subjects and the same metabolite levels were measured after an interval of 30 min. Distribution of the patients according to the ADHD subtypes was as follows: 21 of them (35.0%) were in the inattentive type, 11 of them (18.3%) were in the hyperactive type and 28 of them were (46.7%) in the combined type. Changes of brain metabolite levels after MPH were found not to be statistically significantly different between the subtypes. The increase of choline levels after MPH compared to the levels of choline before MPH in striatum in the combined type patients were statistically significant. No clear association was found between ADHD subtypes and changes of brain metabolites with use of MPH in adult ADHD. © 2015 Elsevier Ireland Ltd.
- Published
- 2015
24. An unusual form of self-mutilation: tongue amputation with local anesthesia
- Author
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Ibrahim Turkcuer, Hasan Herken, and Bulent Erdur
- Subjects
Male ,Resuscitation ,fluphenazine decanoate ,medicine.medical_treatment ,medical examination ,Recurrence ,Testis ,auditory hallucination ,Local anesthesia ,paranoid schizophrenia ,automutilation ,mental patient ,Wechsler Intelligence Scale ,article ,General Medicine ,visual hallucination ,patient assessment ,Treatment Outcome ,medicine.anatomical_structure ,priority journal ,Emergency Medicine ,diagnostic and statistical manual of mental disorders ,Adult ,unemployment ,medicine.medical_specialty ,tongue amputation ,Amputation, Traumatic ,Tongue ,amputation ,Intensive care ,consultation ,medicine ,case report ,follow up ,Humans ,human ,psychiatric department ,nervousness ,Intensive care medicine ,biperiden ,risperidone ,Emergency Services, Psychiatric ,Multiple Trauma ,business.industry ,quetiapine ,clinical feature ,schizophrenia ,Amputation ,Self Mutilation ,neuropsychological test ,local anesthesia ,business ,psychologic assessment ,Anesthesia, Local ,Penis - Abstract
Not Available
- Published
- 2006
25. Lack of association between the 308GA polymorphism of the tumor necrosis factor alpha gene and temporomandibular dysfunction
- Author
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Murat Necip Mutlu, Hasan Herken, Osman A. Etőz, Yildirim Bayazit, and M. Emin Erdal
- Subjects
medicine.medical_specialty ,Pathology ,business.industry ,Gastroenterology ,Molecular analysis ,stomatognathic diseases ,symbols.namesake ,Anesthesiology and Pain Medicine ,Internal medicine ,Healthy volunteers ,symbols ,Medicine ,Tumor necrosis factor alpha ,Neurology (clinical) ,business ,Gene ,Allele frequency ,Fisher's exact test - Abstract
Objective: To assess whether a relationship exists between G308A polymorphism of TNF-α gene and the temporomandibular dysfunction (TMD). Methods: 98 patients with temporomandibular dysfunction, and 132 healthy volunteer controls were included in the study. Molecular analysis of the G308A polymorphism of TNF-α gene was performed using PCR technique. Results: The ages and genders of the patients and controls were similar (Fisher exact test p = 0.5). There was no relationship between TNF 308GA polymorphism and TMD (χ2 = 4.24, p = 0.12). The allele frequencies of the patients and controls were similar (χ2 = 3.25, p = 0.076).
- Published
- 2006
26. Elevated serum nitric oxide and superoxide dismutase in euthymic bipolar patients: Impact of past episodes
- Author
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Ferah Armutcu, H. Ramazan Yilmaz, Suleyman Salih Zoroglu, Salih Selek, Hamdi Tutkun, Haluk A. Savaş, Omer Akyol, Esra Kocoglu, Hasan Serdar Gergerlioglu, and Hasan Herken
- Subjects
Adult ,Male ,medicine.medical_specialty ,Bipolar Disorder ,Time Factors ,Antioxidant ,Adolescent ,Health Status ,medicine.medical_treatment ,Nitric Oxide ,Severity of Illness Index ,Antioxidants ,Nitric oxide ,Elevated serum ,Superoxide dismutase ,Pathogenesis ,chemistry.chemical_compound ,Internal medicine ,mental disorders ,Severity of illness ,medicine ,Humans ,Bipolar disorder ,Biological Psychiatry ,Aged ,Demography ,biology ,Superoxide Dismutase ,business.industry ,Middle Aged ,medicine.disease ,Pathophysiology ,Diagnostic and Statistical Manual of Mental Disorders ,Oxidative Stress ,Psychiatry and Mental health ,Endocrinology ,chemistry ,Immunology ,biology.protein ,Female ,business ,Follow-Up Studies - Abstract
Nitric oxide (NO) has been implicated to play a role in the pathogenesis of many neuropsychiatric disorders. NO level was found high in acute manic inpatients. In this study, we aimed to assess NO level and activity of the antioxidant enzyme, superoxide dismutase (SOD), in euthymic bipolar patients. Twenty-seven patients with bipolar disorder (BD) in euthymic phase, and 20 healthy volunteers were included in this study. A semi-structured form was used to note social, demographic and clinical parameters of the patients. NO level and SOD activity were studied in the serum samples obtained from the patients and controls. The mean serum NO level in BD was significantly higher than in controls. Mean serum SOD activity was found to be elevated in patients with BD compared to controls. Total number of the manic episodes correlated with NO levels, but not with SOD activity. In conclusion, the number of manic episodes is positively associated with NO levels. NO and SOD appear to have a pathophysiological role in BD, especially in Type I euthymic phase, and may be considered an available trait marker for BD.
- Published
- 2006
27. FT-IR spectroscopy and multivariate analysis as an auxiliary tool for diagnosis of mental disorders: Bipolar and schizophrenia cases
- Author
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H.T. Karatepe, G. Ogruc Ildiz, Ozan Ünsalan, Hasan Herken, Olcay Bölükbaşi Yalçinkaya, Erhan Kurt, Mehtap Arslan, Ayberk Yilmaz, and C. Araujo-Andrade
- Subjects
Multivariate analysis ,Bipolar Disorder ,principal component analysis ,Multivariant analysis ,Analytical chemistry ,Diseases ,02 engineering and technology ,Least squares approximations ,Blood plasma ,01 natural sciences ,Analytical Chemistry ,Plasma ,Least-Squares Regression ,Diagnosis ,middle aged ,Spectroscopy, Fourier Transform Infrared ,infrared spectroscopy ,Instrumentation ,Spectroscopy ,Adult ,Bipolar Disorder/*blood/*diagnosis ,Discriminant Analysis ,Humans ,Least-Squares Analysis ,Middle Aged ,Models, Statistical ,Multivariate Analysis ,Plasma/*chemistry ,Principal Component Analysis ,Schizophrenia/*blood/*diagnosis ,Spectroscopy, Fourier Transform Infrared/*methods ,Young Adult ,PCA ,Classification (of information) ,Chemistry ,Fourier transform infrared spectroscopy ,021001 nanoscience & nanotechnology ,Atomic and Molecular Physics, and Optics ,multivariate analysis ,Schizophrenia ,Principal component analysis ,Calibration ,Ft ir spectroscopy ,0210 nano-technology ,PLS ,chemistry ,blood ,least square analysis ,Healthy control ,medicine ,Bipolar disorder ,human ,procedures ,Chemometrics ,business.industry ,010401 analytical chemistry ,statistical model ,Pattern recognition ,medicine.disease ,Linear discriminant analysis ,0104 chemical sciences ,FT-IR ,schizophrenia ,Bipolar ,Artificial intelligence ,business ,Infrared-Spectroscopy ,Biomarkers - Abstract
In this study, a methodology based on Fourier-transform infrared spectroscopy and principal component analysis and partial least square methods is proposed for the analysis of blood plasma samples in order to identify spectral changes correlated with some biomarkers associated with schizophrenia and bipolarity. Our main goal was to use the spectral information for the calibration of statistical models to discriminate and classify blood plasma samples belonging to bipolar and schizophrenic patients. IR spectra of 30 samples of blood plasma obtained from each, bipolar and schizophrenic patients and healthy control group were collected. The results obtained from principal component analysis (PCA) show a clear discrimination between the bipolar (BP), schizophrenic (SZ) and control group' (CG) blood samples that also give possibility to identify three main regions that show the major differences correlated with both mental disorders (biomarkers). Furthermore, a model for the classification of the blood samples was calibrated using partial least square discriminant analysis (PLS-DA), allowing the correct classification of BP, SZ and CG samples. The results obtained applying this methodology suggest that it can be used as a complimentary diagnostic tool for the detection and discrimination of these mental diseases. (C) 2015 Elsevier B.V. All rights reserved.
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- 2014
28. The –308 G/A polymorphism of tumor necrosis factor alpha gene is not associated with migraine
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Mustafa Yilmaz, M. Emin Erdal, Kaan Savasoglu, Hasan Herken, and Yildirim Bayazit
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medicine.medical_specialty ,business.industry ,Aura ,medicine.disease ,Epilepsy ,Anesthesiology and Pain Medicine ,Endocrinology ,Migraine ,Anesthesia ,Internal medicine ,Genotype ,Medicine ,Neurology (clinical) ,Allele ,Family history ,business ,Gene ,Allele frequency - Abstract
Background and objective: To investigate the association between 308 G/A polymorphism of TNF-α gene and migraine. Methods: Polymerase chain reaction-restriction fragment length polymorphism assay was used to determine TNF-308 G/A polymorphism in 60 migraineurs and 62 healthy controls. Results: There was no significant relationship between TNF-α–308 G/A polymorphism and gender, family history of epilepsy, family history of migraine and aura. In the control group, the frequencies of G and A alleles were 0.93 and 0.07, respectively. The corresponding values were 0.94 and 0.06 in the migraineurs. There was no significant difference between the allele frequencies and genotypes of the migraineurs and controls (p = 0.85). Conclusion: TNF-α–308 G/A polymorphism is not associated with migraine and aura.
- Published
- 2005
29. Monoamine oxidase-A gene promoter polymorphism in temporomandibular joint pain and dysfunction
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M. Emin Erdal, Yildirim Bayazit, Gulsun Oz, Hasan Herken, Necip Mutlu, Nurten Erdal, and Mahmut Ozkaya
- Subjects
musculoskeletal diseases ,Pathology ,medicine.medical_specialty ,Temporomandibular joint pain ,business.industry ,Promoter polymorphism ,Promoter ,Bioinformatics ,stomatognathic diseases ,Anesthesiology and Pain Medicine ,Monoamine neurotransmitter ,Pain Clinics ,stomatognathic system ,Polymorphism (computer science) ,Monoamine Oxidase A Gene ,Medicine ,Neurology (clinical) ,business - Abstract
(2005). Monoamine oxidase-A gene promoter polymorphism in temporomandibular joint pain and dysfunction. The Pain Clinic: Vol. 17, No. 1, pp. 39-44.
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- 2005
30. Association between Ala–9Val polymorphism of Mn-SOD gene and schizophrenia
- Author
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Suleyman Salih Zoroglu, Medaim Yanik, Halit Canatan, Hüseyin Yüce, Haluk Akin, Sadik Sogut, Hamdi Tutkun, Huseyin Ozyurt, H. Ramazan Yilmaz, Halit Elyas, Haluk A. Savaş, Hasan Herken, Ömer Akyol, and Mustafa Namli
- Subjects
Adult ,Male ,Dyskinesia, Drug-Induced ,medicine.medical_specialty ,Genotype ,Superoxide dismutase ,Gene Frequency ,Internal medicine ,medicine ,Humans ,Allele ,Gene ,Alleles ,Biological Psychiatry ,Genetic association ,Pharmacology ,Genetics ,chemistry.chemical_classification ,Reactive oxygen species ,Polymorphism, Genetic ,biology ,Reverse Transcriptase Polymerase Chain Reaction ,Superoxide Dismutase ,Brain ,Middle Aged ,Oxidative Stress ,Endocrinology ,Amino Acid Substitution ,chemistry ,Schizophrenia ,biology.protein ,Female ,Gene polymorphism ,Restriction fragment length polymorphism ,Reactive Oxygen Species ,Antipsychotic Agents - Abstract
Reactive oxygen species (ROS) have been suggested to play an important role in physiopathology of schizophrenia. The major intracellular antioxidant enzymes, copper-zinc superoxide dismutase in the cytoplasm and manganese superoxide dismutase (Mn-SOD) in the mitochondria, rapidly and specifically reduce superoxide radicals to hydrogen peroxide. Polymorphisms in the genes encoding antioxidant enzymes should therefore result in predisposition to schizophrenia. The present study was performed to assess; whether there is a genetic association between a functional polymorphism (Ala-9Val) in the human Mn-SOD gene in schizophrenic patients (n=153) and healthy controls (n=196) using a PCR/RFLP method. Significant differences in the genotypic distribution between schizophrenics and controls were observed. Genotypic distribution with 14 (9.2%) Ala/Ala, 106 (69.3%) Ala/Val and 33 (21.6%) Val/Val subjects, in schizophrenia was different from those of controls with 46 (23.5%), 83 (42.3%) and 67 (34.21/6), respectively (p, Reactive oxygen species (ROS) have been suggested to play an important role in physiopathology of schizophrenia. The major intracellular antioxidant enzymes, copper-zinc superoxide dismutase in the cytoplasm and manganese superoxide dismutase (Mn-SOD) in the mitochondria, rapidly and specifically reduce superoxide radicals to hydrogen peroxide. Polymorphisms in the genes encoding antioxidant enzymes should therefore result in predisposition to schizophrenia. The present study was performed to assess whether there is a genetic association between a functional polymorphism (Ala-9Val) in the human Mn-SOD gene in schizophrenic patients (n=153) and healthy controls (n=196) using a PCR/RFLP method. Significant differences in the genotypic distribution between schizophrenics and controls were observed. Genotypic distribution with 14 (9.2%) Ala/Ala, 106 (69.3%) Ala/Val and 33 (21.6%) Val/Val subjects in schizophrenia was different from those of controls with 46 (23.5%), 83 (42.3%) and 67 (34.2%), respectively (p
- Published
- 2005
31. Monoamine oxidase-A gene promoter polymorphism in female migraineurs
- Author
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Mustafa Yilmaz, Hasan Herken, M. Emin Erdal, and Yildirim Bayazit
- Subjects
medicine.medical_specialty ,business.industry ,Aura ,Promoter ,Anesthesiology and Pain Medicine ,Endocrinology ,Monoamine neurotransmitter ,Polymorphism (computer science) ,Internal medicine ,Genotype ,medicine ,Neurology (clinical) ,Gene polymorphism ,Allele ,Psychiatry ,business ,Allele frequency - Abstract
Objective: To assess whether there is a relationship between monoamine oxidase-A (MAOA) gene promoter polymorphism and migraine in female patients. Study design: A polymerase chain reaction based study in which MAOA promoter polymorphism was studied in 54 female migraineurs and 52 controls. Methods: The low (3-repeat) and high (one of 3.5, 4 or 5 repeat units) activity MAOA alleles were detected. The genotypes and allele frequencies were compared both within and between the groups. Results: The representation of both low (1/1) and high (2/2) activity genotypes were similar between the female migraineurs and controls. The allele frequencies were also similar between these groups. There was no relationship between the presence or absence of aura and MAO polymorphism. Conclusion: MAOA gene polymorphism is not associated with migraine or aura in female patients.
- Published
- 2003
32. Migraine and angiotensin-converting enzyme association in Turkish patients
- Author
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Tahir Kurtuluş Yoldaş, Ecir Alicakmak, Remzi Yigiter, Hasan Herken, Ahmet Arslan, Ömer Barlas, Senay Gorucu, and Osman Çataloluk
- Subjects
medicine.medical_specialty ,biology ,Turkish ,business.industry ,Angiotensin-converting enzyme ,medicine.disease ,language.human_language ,Anesthesiology and Pain Medicine ,Endocrinology ,Mood disorders ,Migraine ,Polymorphism (computer science) ,Internal medicine ,Genotype ,medicine ,language ,biology.protein ,Neurology (clinical) ,Allele ,Association (psychology) ,business - Abstract
Although there are an increasing number of publications claiming involvement of the ACE I/D polymorphism in mood disorders, none of them has been able to show any linkage between allele and genotypical distributions and psychiatric disorders. We investigated the possibility of association between ACE I/D polymorphism and migraine in 200 migraineurs and 231 control subjects of Turkish origin. No association was found between ACE I/D polymorphism and migraine. However, the results of our study suggested that the DD genotype is more frequent in men than in women.
- Published
- 2003
33. Significance of catechol-O-methyltransferase gene polymorphism in myofacial pain syndrome
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M. Emin Erdal, Yildirim Bayazit, M. Necip Mutlu, and Hasan Herken
- Subjects
medicine.medical_specialty ,Catechol-O-methyl transferase ,business.industry ,fungi ,Myofacial Pain ,Control subjects ,behavioral disciplines and activities ,Anesthesiology and Pain Medicine ,Endocrinology ,nervous system ,Catechol-O-Methyltransferase Gene ,Polymorphism (computer science) ,Internal medicine ,mental disorders ,Genotype ,Physical therapy ,Medicine ,Comt gene ,Neurology (clinical) ,Restriction fragment length polymorphism ,business - Abstract
The objective was to investigate possible association of the catechol o-methyl transferase (COMT) gene polymorphisms with myofacial pain syndrome (MFPS). The polymorphism of the COMT gene was compared between 49 patients with MFPS and 113 control subjects. Relationship between COMT polymorphism and psychiatric status of the patients was also assessed using SCL-90-R, BDS, and STAI-I and II tests. A PCR-based restriction fragment length polymorphism assay was used to detect G → A transition at position 1947 in COMT. There was no relationship between MFPS and COMT polymorphism (p > 0.05). The patients who had MFPS without any temporomandibular joint problem had significantly higher expression of LL genotype when compared to those with joint problems (p 0.05). In conclusion, MFPS is not related to COMT polymorphism. COMT polymorphism is not associated with the psychiatric status of the patients. COMT polymorphism m...
- Published
- 2003
34. Tardive dyskinesia is not associated with the polymorphisms of 5-HT2A receptor gene, serotonin transporter gene and catechol-o-methyltransferase gene ⋆
- Author
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Hasan Herken, Haluk A. Savaş, M. Emin Erdal, and Ömer Böke
- Subjects
Adult ,Male ,Dyskinesia, Drug-Induced ,Psychosis ,medicine.medical_specialty ,Methyltransferase ,Nerve Tissue Proteins ,Catechol O-Methyltransferase ,Tardive dyskinesia ,Polymerase Chain Reaction ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Polymorphism (computer science) ,Internal medicine ,mental disorders ,medicine ,Humans ,Receptor, Serotonin, 5-HT2A ,030212 general & internal medicine ,Gene ,Serotonin transporter ,Serotonin Plasma Membrane Transport Proteins ,Genetics ,Membrane Glycoproteins ,Polymorphism, Genetic ,Catechol-O-methyl transferase ,biology ,Membrane Transport Proteins ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Endocrinology ,Dyskinesia ,Case-Control Studies ,Receptors, Serotonin ,Schizophrenia ,biology.protein ,Female ,medicine.symptom ,Carrier Proteins ,Antipsychotic Agents - Abstract
BackgroundThe pathophysiology of tardive dyskinesia (TD) is not completely understood.AimTo assess the relationship of TD with 5-HT2A receptor gene, serotonin transporter gene (5 HTT), and catechol-o-methyltransferase (COMT) gene polymorphisms.MethodsOur study comprised 111 unrelated subjects who strictly met DSM-IV criteria for schizophrenia and 32 TD, and 79 healthy unrelated controls; all the subjects were of Turkish origin. The analyses of 5-HT2A receptor gene, 5 HTT gene, and COMT gene polymorphisms were performed using polymerase chain reaction (PCR) technique.ResultsThe polymorphisms of these genes were not significantly different between the schizophrenic patients, TD and control subjects.ConclusionsOur findings indicated that 5-HT2A receptor gene, 5 HTT gene, and COMT gene polymorphisms were similar in schizophrenia with non-TD, schizophrenia with TD, and healthy controls. These polymorphisms, though, do not help to evaluate the susceptibility to TD.
- Published
- 2003
35. Pathophysiological role of nitric oxide and adrenomedullin in autism
- Author
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Hamdi Tutkun, Özer Yetki̇n, Suleyman Salih Zoroglu, Ercan Sivasli, Sadik Sogut, Omer Akyol, Haluk A. Savaş, Muhittin Yürekli, İclal Meram, Medaim Yanik, and Hasan Herken
- Subjects
medicine.medical_specialty ,business.industry ,Clinical Biochemistry ,Cell Biology ,General Medicine ,Peptide hormone ,medicine.disease ,Biochemistry ,Nitric oxide ,Adrenomedullin ,chemistry.chemical_compound ,Endocrinology ,chemistry ,Schizophrenia ,Internal medicine ,Pervasive developmental disorder ,medicine ,Autism ,Bipolar disorder ,Neurotransmitter ,business - Abstract
Several studies indicate that nitric oxide (NO) is involved in the aetiopathogenesis of many neuropsychiatric disorders such as schizophrenia, bipolar disorder, depression, Alzheimer's disease, Hungtington disease and stroke. Although it has not been investigated yet, several recent studies proposed that NO may have a pathophysiological role in autism. Adrenomedullin (AM), a recently discovered 52-amino acid peptide hormone, induces vasorelaxation by activating adenylate cyclase and also by stimulating NO release. AM immune reactivity is present in the brain consistent with a role as a neurotransmitter. It has been stated that NO and AM do function in the regulation of many neurodevelopmental processes. We hypothesized that NO and AM activities have been affected in autistic patients and aimed to examine these molecules. Twenty-six autistic patients and 22 healthy control subjects were included in this study. AM and total nitrite (a metabolite of NO) levels have been measured in plasma. The mean values of plasma total nitrite and AM levels in the autistic group were significantly higher than control values, respectively (p < 0.001, p = 0.028). There is no correlation between total nitrite and AM levels (r = 0.11, p = 0.31). Certainly, this subject needs much further research investigating autistic patients in earlier periods of life and with subtypes of the disorder.
- Published
- 2002
36. The indices of endogenous oxidative and antioxidative processes in plasma from schizophrenic patients
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Omer Akyol, Süheyla Ünal, Efkan Uz, Sadik Sogut, Hasan Herken, Haluk A. Savaş, Ersin Fadillioglu, and Huseyin Ozyurt
- Subjects
Pharmacology ,chemistry.chemical_classification ,medicine.medical_specialty ,Antioxidant ,biology ,business.industry ,Glutathione peroxidase ,medicine.medical_treatment ,medicine.disease_cause ,Nitric oxide ,Superoxide dismutase ,chemistry.chemical_compound ,Endocrinology ,chemistry ,Biochemistry ,Internal medicine ,biology.protein ,TBARS ,Medicine ,Xanthine oxidase ,business ,Chlorpromazine ,Biological Psychiatry ,Oxidative stress ,medicine.drug - Abstract
There is great evidence in recent years that oxygen free radicals play an important role in the pathophysiology of schizophrenia. The present study was performed to assess the changes in plasma nitric oxide (NO) and thiobarbituric acid-reactive substances (TBARS) levels, and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and xanthine oxidase (XO) activities in schizophrenic patients compared to age- and sex-matched normal controls. A hundred patients with schizophrenia and 51 healthy volunteers were included in the study. XO, SOD, and GSH-Px activities as well as NO and TBARS levels were estimated by standard biochemical techniques in the plasma of normal healthy controls and schizophrenia patients. In schizophrenia, increased plasma XO activity (P < .0001) and NO levels (P < .0001), decreased SOD activity (P < .0001), and unchanged GSH-Px activity were detected compared to control group. Plasma TBARS levels were increased in schizophrenic patients (P < .01), especially in the residual subtype. TBARS levels in nonsmoker schizophrenic patients were found to be higher than nonsmoker controls. Although TBARS levels in both patients and controls were found to be higher in smokers as compared to nonsmokers, it was not statistically significant. No effects of duration of the illness, gender, and low and high dose of daily neuroleptic treatment equivalent to chlorpromazine on oxidant and antioxidant parameters were observed. Because the dose and the duration of treatment with drugs have no influence on the results, it can be interpreted that the findings are more likely to be related mainly to the underlying disease. These findings indicated a possible role of increased oxidative stress and diminished enzymatic antioxidants, both of which may be relevant to the pathophysiology of schizophrenia. On the other hand, increased NO production by nitric oxide synthetases (NOSs) suggests a possible role of NO in the pathophysiological process of schizophrenia. These findings may also suggest some clues for the new treatment strategies with antioxidants and NO synthase (NOS) inhibitors in schizophrenia.
- Published
- 2002
37. Significance of Serotonin Transporter Gene 5-HTTLPR and Variable Number of Tandem Repeat Polymorphism in Attention Deficit Hyperactivity Disorder
- Author
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Mehmet Emin Erdal, Belgin Alasehirli, Hasan Herken, Nurten Erdal, Ercan Sivasli, Hamdi Tutkun, Haluk A. Savaş, and Suleyman Salih Zoroglu
- Subjects
Male ,Serotonin ,Adolescent ,Genotype ,Turkey ,Nerve Tissue Proteins ,Polymerase Chain Reaction ,Polymorphism (computer science) ,mental disorders ,medicine ,Humans ,Attention deficit hyperactivity disorder ,Allele ,Child ,Biological Psychiatry ,Serotonin transporter ,Serotonin Plasma Membrane Transport Proteins ,Genetics ,Membrane Glycoproteins ,Polymorphism, Genetic ,biology ,Case-control study ,Membrane Transport Proteins ,medicine.disease ,Psychiatry and Mental health ,Variable number tandem repeat ,Neuropsychology and Physiological Psychology ,Attention Deficit Disorder with Hyperactivity ,Tandem Repeat Sequences ,Case-Control Studies ,5-HTTLPR ,biology.protein ,Female ,Carrier Proteins ,Psychology - Abstract
The purpose of this study was to evaluate the relationship between attention deficit hyperactivity disorder (ADHD) and polymorphism of the two regions of the 5-HTT gene [variable number of tandem repeats (VNTR) and 5-HTTLRR] in a sample of Turkish children. Using the PCR technique, these polymorphisms were assessed in 71 patients with ADHD and 128 healthy controls. The 5-HTTLPR S/S genotype was significantly lower in the patients than in the controls (p = 0.018). Homozygous and heterozygous L variant predominated in the ADHD group. But the VNTR STin2.12/12 genotype was significantly less found in the patients than in the controls (p = 0.001). There was no significant difference between the frequency of the short (S), long, 10, and 12 alleles of both groups. The lack of an S/S variant of 5-HTTLPR polymorphism of the STin2.12/12 variant of VNTR polymorphism appears to be associated with an increased risk of ADHD.
- Published
- 2002
38. Hippocampal Volume in Schizophrenia and Its Relationship with Risperidone Treatment: A Stereological Study
- Author
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Hulya Erbagci, Serap Inaloz, Hasan Herken, Sinan Canan, Bunyami Unal, Suleyman Salih Zoroglu, Erdem Gumusburun, Haluk A. Savaş, and Ondokuz Mayıs Üniversitesi
- Subjects
Adult ,Male ,Psychosis ,Models, Neurological ,hippocampal volume ,Cavalieri's method ,Hippocampal formation ,Hippocampus ,Functional Laterality ,medicine ,magnetic resonance imaging ,Humans ,Hippocampus (mythology) ,risperidone treatment ,Biological Psychiatry ,Psychiatric Status Rating Scales ,Risperidone ,medicine.diagnostic_test ,business.industry ,Body Weight ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,schizophrenia ,Psychiatry and Mental health ,Neuropsychology and Physiological Psychology ,Schizophrenia ,Coronal plane ,Hippocampal volume ,Female ,Psychology ,Nuclear medicine ,business ,Neuroscience ,Algorithms ,Antipsychotic Agents ,medicine.drug - Abstract
Gumusburun, Erdem/0000-0002-2223-2748; Canan, Sinan/0000-0002-9864-1767 WOS: 000178706300002 PubMed: 12378121 The purpose of this study was to assess the significance of the hippocampal volume differences and its relation with risperidone treatment in schizophrenia. In schizophrenic patients who were on risperidone treatment (n = 11) and in healthy volunteers (n = 11), volumes of the hippocampi were estimated using magnetic resonance images (MRIs). A detailed systematic series of coronal MRIs of the entire brain (3 mm thickness, T-1-weighted, TR/TE 400/10 ms) was obtained for each subject. All estimations were done according to Cavalieri's method by a modified point-counting grid placed on surface areas of hippocampal slices. The mean right and left hippocampal volumes in schizophrenics and control subjects were 1,059.4 and 1,003.2 mm(3), and 1,780.1 and 1,589.1 mm(3), respectively. The corresponding coefficients of errors were 0.05 and 0.068, and 0.059 and 0.081, respectively. The volumes of left and right hemispheres were not significantly different in both schizophrenic patients and controls (p > 0.05). However, a statistically significant difference (p < 0.05) was found between hippocampal volumes of the schizophrenic patients and controls. In conclusion, the hippocampal volume of the schizophrenic patients is significantly smaller than of the healthy controls. The patients who responded well to risperidone treatment had significantly greater hippocampal volumes than the patients who did not respond properly. Thus, hippocampal volume may be a predictor of the treatment response of schizophrenics to risperidone. Copyright (C) 2002 S. Karger AG, Basel.
- Published
- 2002
39. Massive uvula oedema during lithium therapy and resolution after lithium discontinuation
- Author
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Osman Virit, Murat Eren Özen, Esen Savas, Haluk A. Savaş, Hasan Herken, Yildirim Bayazit, Salih Selek, and Hamdi Tutkun
- Subjects
Psychiatry and Mental health ,Acute oedema ,Lithium (medication) ,genetic structures ,stomatognathic system ,business.industry ,Lithium therapy ,Anesthesia ,mental disorders ,Medicine ,business ,Discontinuation ,medicine.drug - Abstract
Acute oedema of the uvula is relatively rare, and often idiopathic. There are only a few cases reported up to date. This is the first case of oedema in the uvula that occurred during lithium treatment of a patient with bipolar-I manic disorder.
- Published
- 2014
40. Association of SNAP-25 Gene Ddel and Mnll Polymorphisms with Adult Attention Deficit Hyperactivity Disorder
- Author
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G.A. Unal, Ayse Nur Inci Kenar, Mustafa Ertan Ay, Hasan Herken, Tuba Gökdoğan Edgünlü, Mehmet Emin Erdal, Burcu Çakaloz, Cem Şengül, Erinç Yücel, MÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, and Edgünlü, Tuba
- Subjects
Oncology ,medicine.medical_specialty ,Turkish population ,genetic association ,Vesicle docking ,genotype ,polymerase chain reaction ,attention deficit disorder ,SNAP-25 gene ,genetic analysis ,Adult ADD ADHD DSM IV Based Diagnostic Screening and Rating Scale ,gene frequency ,Bioinformatics ,behavioral disciplines and activities ,Article ,assessment of humans ,male ,Genetic ,Polymorphism (computer science) ,Rating scale ,Internal medicine ,Genotype ,mental disorders ,medicine ,Attention deficit hyperactivity disorder ,ADHD ,controlled study ,human ,Gene ,Biological Psychiatry ,restriction fragment length polymorphism ,business.industry ,adult ,Snap ,medicine.disease ,DNA isolation ,major clinical study ,Wender Utah Rating Scale ,Psychiatry and Mental health ,stomatognathic diseases ,female ,synaptosomal associated protein 25 ,DNA polymorphism ,Original Article ,disease severity ,business ,SNAP-25 Gene - Abstract
Objective The synaptosomal-associated protein of 25 kDa (SNAP-25) gene is a presynaptic plasma membrane protein and an integral component of the vesicle docking and fusion machinery mediating secretion of neurotransmitters. Previously, several studies reported association between SNAP-25 and attention deficit hyperactivity disorder (ADHD). We investigated whether these SNAP-25 polymorphisms (MnlI T/G and DdelI T/C) were also associated with ADHD in the Turkish population. Methods: Our study comprised unrelated 139 subjects who met DSM-IV criteria for ADHD and 73 controls and all were of Turkish origin. Genetic analyses were performed and patients were evaluated with Wender-Utah Rating Scale and Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale. Results: SNAP-25 DdelI polymorphism was not associated with ADHD but there was a statistically significant difference between ADHD patients and controls for SNAP-25 MnlI polymorphism. For SNAP-25 MnlI polymorphism patients with G/G genotype of the SNAP-25 gene MnlI polymorphism had higher Wender-Utah scores and higher scores in the 1st and 3rd parts of adult ADD/ADHD Scale. Conclusion: We detected a significant association of the MnlI polymorphism in our ADHD sample which was similar to previous findings. Our study also revealed that SNAP-25 MnlI polymorphism was also associated with symptom severity of ADHD. This study is also, the first report on the association of SNAP-25 with ADHD in the Turkish population. © 2014 Korean Neuropsychiatric Association.
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- 2014
41. Association of VAMP-2 and syntaxin 1A genes with adult attention deficit hyperactivity disorder
- Author
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Mehmet Emin Erdal, Özlem İzci Ay, Aẙe Nur Inci Kenar, and Hasan Herken
- Subjects
Syntaxin 1A ,genetic association ,intron ,genotype ,polymerase chain reaction ,attention deficit disorder ,genetic analysis ,gene frequency ,Genetic analysis ,Structured Clinical Interview for DSM Disorders ,synaptobrevin 2 gene ,Genetic ,male ,Dopamine ,Polymorphism (computer science) ,mental disorders ,middle aged ,medicine ,Attention deficit hyperactivity disorder ,ADHD ,controlled study ,human ,gene ,Gene ,Biological Psychiatry ,restriction fragment length polymorphism ,Genetics ,adult ,Dopaminergic ,Intron ,allele ,article ,Synaptobrevin 2 ,genotype environment interaction ,syntaxin 1A gene ,medicine.disease ,VAMP-2 ,major clinical study ,Psychiatry and Mental health ,dopaminergic system ,female ,DNA polymorphism ,Etiology ,young adult ,Original Article ,Psychology ,Neuroscience ,medicine.drug - Abstract
Objective The etiology of attention deficit hyperactivity disorder (ADHD) has not been entirely clarified yet. Structural and metabolic differences at the prefrontal striatal cerebellary system and the interaction of gene and environment are the main factors that thought to play roles in the etiology. Genetic investigations are performed especially about the dopamine pathways and receptors. In this study; it was aimed to investigate the association of the synaptobrevin-2 (VAMP-2) gene Ins/Del polymorphism and syntaxin 1A gene intron 7 polymorphism, which take place in encoding presynaptic protein, with adult ADHD. Methods One hundred thirty-nine patients, having ADHD aging between 18 and 60 years and 106 healthy people as controls were included into the study. DNA samples were extracted from whole blood and genetic analysis were performed. Results A significant difference was determined between ADHD and VAMP-2 Ins/Del polymorphism and syntaxin 1A intron 7 polymorphism according to the control group. These polymorphisms were found not to be associated with subtypes of ADHD. Conclusion It is supposed that synaptic protein genes together with dopaminergic genes might have roles in the etiology of ADHD. © 2014 Korean Neuropsychiatric Association.
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- 2014
42. Association of the DRD2 TaqIA, 5-HT1B A-161T, and CNR1 1359 G/A polymorphisms with alcohol dependence
- Author
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Özlem İzci Ay, Hasan Herken, Muharrem Efe, Cem Şengül, Mehmet Emin Erdal, Mustafa Ertan Ay, and Melike Ceyhan Balcı Şengül
- Subjects
structured questionnaire ,medicine.medical_specialty ,genetic association ,genotype ,genetic analysis ,Bioinformatics ,Structured Clinical Interview for DSM Disorders ,Glutamatergic ,male ,single nucleotide polymorphism ,genetic variability ,medicine ,5-HT1B A-161T ,DRD2 TaqIA ,genetic polymorphism ,controlled study ,Pharmacology (medical) ,human ,Polymorphism ,Psychiatry ,Gene ,restriction fragment length polymorphism ,alcoholism ,Farmakoloji ve Eczacılık ,adult ,disease association ,Alcohol dependence ,Dopaminergic ,allele ,article ,Genetic variants ,endocannabinoid ,serotonin 1B receptor ,major clinical study ,CNR1 1359 G/A ,Psychiatry and Mental health ,female ,genotyping technique ,Opioid ,real time polymerase chain reaction ,Cholinergic ,Psychology ,medicine.drug - Abstract
Objective: Alcohol dependence is associated with genetic variants of alcohol-metabolizing enzymes and genes related to dopaminergic, gamma-aminobutyric acidergic, glutamatergic, opioid, cholinergic, and serotonergic systems. Genetic variations in the endogenous cannabinoid system are also involved in alcohol dependence. The present study aimed to evaluate the association between three polymorphisms, DRD2 TaqIA, 5-HT1B A-161T and CNR1 1359 G/A (rs1049353), and alcohol dependence. Methods: One hundred twenty three patients, who were diagnosed as having alcohol dependence according to the DSM-IV criteria and 125 healthy volunteers, were included in the study. With written informed consent, a blood sample was drawn from each individual. Venous blood samples were collected in ethylenediaminetetra acetic acid (EDTA) containing tubes. DNA was extracted from whole blood by the salting out procedure. Genetic analyses were performed as described in the literature by using a Polymerase Chain Reaction method. SPSS 17.0 software was used for statistical analysis. Results: The DRD2 TaqIA polymorphism was analyzed in the study and control groups. In the study group, the A1/ A1 genotype was observed in 5 (4.0%) patients, the A1/ A2 genotype was observed in 51 (41.5%) patients and the A2/A2 genotype was observed in 67 (54.5%) patients. In the control group, the A1/A1 genotype was observed in 6 (4.8%) subjects, the A1/A2 genotype was observed in 40 (32.0%) subjects and the A2/A2 genotype was observed in 79 (62.2%) subjects. For the 5-HT1B receptor A-161T gene polymorphism, the A/A genotype was detected in 61 (49.6%) patients, the A/T genotype was detected in 53 (43.1%) and the T/T genotype was detected in 9 (7.3%) patients. In the control group, the A/A genotype was detected in 84 (67.2%) subjects, the A/T genotype was detected in 39 (31.2%) subjects, and the T/T genotype was detected only in 2 (1.6%) subjects. The G/G genotype was the most common genotype in both study and control groups for CNR1 1359 gene polymorphism. It was detected in 75 (61.0%) study patients and in 84 (67.2%) control subjects. The G/A genotype was observed in 39 (31.7%) patients of the study group and 38 (30.4%) subjects of the control group. The A/A genotype was the most rare genotype in both groups; it was detected only in 9 (7.3%) study patients and 3 (2.4%) control subjects. Of the three polymorphisms investigated, 5-HT1B A-161T was the only one found to be associated with alcohol dependence. Conclusions: The 5-HT1B receptor A-161T polymorphism might be a promising marker for alcohol dependence; however, future studies are needed to clarify these findings.
- Published
- 2014
43. Risk of psychotropic drug interactions in real world settings: A pilot study in patients with schizophrenia and schizoaffective disorder
- Author
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Hasan Herken, Filiz Karadag, Melike Ceyhan Balcı Şengül, Cem Şengül, Ozgur Kalkanci, and Kamuran Karakülah
- Subjects
hypotension ,extrapyramidal symptom ,neuroleptic agent ,zuclopenthixol ,haloperidol ,0302 clinical medicine ,venlafaxine ,neurotoxicity ,Medicine ,Pharmacology (medical) ,citalopram ,chlorpromazine ,risk ,anticholinergic syndrome ,clozapine ,sertraline ,adult ,pilot study ,fluphenazine ,pimozide ,liver toxicity ,Psychiatry and Mental health ,Psychotropic drug ,female ,Schizophrenia ,lithium ,carbamazepine ,lamotrigine ,paliperidone ,fluvoxamine ,Clinical psychology ,paroxetine ,cardiovascular risk ,medicine.medical_specialty ,Schizoaffective disorder ,Drug interaction ,respiration depression ,olanzapine ,ziprasidone ,QT prolongation ,Psychotropic ,psychotropic agent ,bradycardia ,Article ,03 medical and health sciences ,aripiprazole ,DSM-IV ,male ,valproic acid ,unindexed drug ,In patient ,propranolol ,human ,polypharmacy ,Psychiatry ,mirtazapine ,Polypharmacy ,risperidone ,business.industry ,fluoxetine ,tricyclic antidepressant agent ,quetiapine ,medicine.disease ,major clinical study ,schizoaffective psychosis ,030227 psychiatry ,schizophrenia ,amisulpride ,Concomitant ,drug blood level ,flupentixol ,central nervous system depression ,teratogenesis ,business ,030217 neurology & neurosurgery - Abstract
Objective: The rate of polypharmacy is increasing in patients with psychotic disorders. Polypharmacy is defined as the concomitant use of two or more drugs at a time. As most psychotropic medications are metabolized via the cytochrome enzyme system, it is easy to predict that polypharmacy will increase the risk of drug-drug interactions. This study was planned to evaluate the interaction risks of medications used by patients with a diagnosis of schizophrenia and schizoaffective disorder., Method: This study enrolled inpatients and outpatients of 18-65 years of age, diagnosed with schizophrenia or schizoaffective disorder according to the DSM-IV classification, who had been receiving antipsychotics for at least 12 weeks. Co-administration of antipsychotic and other psychotropic drugs for at least 4 weeks was recorded as polypharmacy. The risk of interaction was determined as follows: all medications one patient was using were sent to the internet site https://drugs.com as individual treatment regimens, and interaction information for healthcare specialists was used., Results: The study sample consisted of 240 patients (141 males; 58.8%; 99 females; 41.2%) in total, with the schizophrenia spectrum of diseases (schizophrenia, schizoaffective disorder). One hundred and thirty six (56.6%) patients used only one antipsychotic and 104 (43.4%) patients used 2 or more antipsychotics. The mean number of medications was 2.58±1.22 (min 1-max 6), the mean number of interactions was 1.90±2.04 (min 1-max 10). One hundred and seventy two (71.7%) patients were taking medications with a risk of interaction, with 417 total drug interaction risks. Of the interaction risks, 87.8% (total number 366) were at a moderate level. Approximately one quarter of the patients (n=42, 24.4%) were using medications with a major risk, and two patients (1.2%) were taking drugs with a minor risk of interaction. Among probable outcomes of drug interactions, the first 3 places were occupied by a risk of anticholinergic side effects, a risk of CNS or respiratory depression and a risk of QT prolongation., Conclusion: The present study reports that an important percentage of patients are exposed to drug-drug interactions with ever-increasing use of multiple medications in the schizophrenia spectrum of diseases, and among these interactions, most major risks were cardiovascular risks, especially QT prolongation. Prospective studies with larger numbers of patients are needed in this area. © 2014, Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali. All rights reserved.
- Published
- 2014
44. Significance of the catechol-O-methyltransferase gene polymorphism in migraine
- Author
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Mustafa Yilmaz, Hasan Herken, Yildirim Bayazit, and M. Emin Erdal
- Subjects
Adult ,Male ,Migraine without Aura ,Heterozygote ,medicine.medical_specialty ,Genotype ,Aura ,Migraine with Aura ,Biology ,Catechol O-Methyltransferase ,behavioral disciplines and activities ,Pathogenesis ,Cellular and Molecular Neuroscience ,Polymorphism (computer science) ,Internal medicine ,mental disorders ,medicine ,Humans ,Family history ,Allele ,Molecular Biology ,Polymorphism, Genetic ,Catechol-O-methyl transferase ,Homozygote ,fungi ,Middle Aged ,medicine.disease ,Endocrinology ,Migraine ,Female - Abstract
The objective was to assess the significance of the catechol-o-methyltransferase (COMT) enzyme polymorphism in migraine. For this reason, 62 migraineurs and 64 healthy volunteers were included in the study. The analysis of COMT polymorphism was performed using PCR. The H/H genotype was more frequent in the control group than in the patients group (P=0.032). The homozygous or heterozygous L allele was over represented in the migraineurs compared with the controls (P=0.013). The L/L genotype was over represented in the migraineurs who also had a family history of migraine (P=0.003). There was no relationship between aura and COMT genotypes. In conclusion, the COMT polymorphism may be of potential pharmacological importance regarding the individual differences in the metabolism of catechol drugs in migraineurs. Although altered catecholamine activity due to polymorphism of COMT gene may be one of the mechanisms involved in the pathogenesis of migraine, these mechanisms are not related to presence or absence of aura.
- Published
- 2001
45. Association of T102C polymorphism of the 5-HT2A receptor gene with pyschiatric status in fibromyalgia syndrome
- Author
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Hasan Herken, Belgin Alasehirli, Emin Erdal, Savaş Gürsoy, and Ercan Madenci
- Subjects
Adult ,Male ,medicine.medical_specialty ,Fibromyalgia ,Molecular Sequence Data ,Immunology ,Serotonergic ,Polymerase Chain Reaction ,Severity of Illness Index ,Genetic determinism ,Rheumatology ,Reference Values ,Internal medicine ,Genotype ,medicine ,Humans ,Immunology and Allergy ,Receptor, Serotonin, 5-HT2A ,Receptor ,Probability ,Analysis of Variance ,Chi-Square Distribution ,Polymorphism, Genetic ,business.industry ,Syndrome ,Middle Aged ,medicine.disease ,Endocrinology ,Psychotic Disorders ,Receptors, Serotonin ,Etiology ,Female ,Analysis of variance ,Gene polymorphism ,business - Abstract
Serotonin (5-HT) is a key neurotransmitter in the central nervous system. It is suggested that serotonergic dysfunction may be involved in the pathophysiology of fibromyalgia syndrome (FS). In this study, we aimed to investigate T102C polymorphism of the 5-HT2A receptor gene in FS. Fifty-eight patients with FS and 58 unrelated healthy volunteer controls were included in the study. In both groups, the C/C, C/T, and T/T genotypes of the 5-HT gene were represented in 31% (22.4% in controls), 50% (53.4%), and 19% (24.1%), respectively. The 5-HT2A receptor gene polymorphism results were not significantly different between patients and controls (chi squared test, P>0.05). There was a significant correlation between patients with the T/T genotype and the subgroup according to the SCL-90-R test, (analysis of variance, P
- Published
- 2001
46. Possible association of temporomandibular joint pain and dysfunction with a polymorphism in the serotonin transporter gene
- Author
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Ömer Barlas, Necip Mutlu, Fatih Oz, Emin Erdal, Hasan Herken, Osman Çataloluk, and Enis Güray
- Subjects
Adult ,Male ,musculoskeletal diseases ,Serotonin ,medicine.medical_specialty ,Pathology ,Personality Inventory ,Nerve Tissue Proteins ,Orthodontics ,Minisatellite Repeats ,Gastroenterology ,Polymorphism (computer science) ,Internal medicine ,Genotype ,medicine ,Genetic predisposition ,Humans ,Genetic Predisposition to Disease ,Allele ,Somatoform Disorders ,Serotonin transporter ,Probability ,Serotonin Plasma Membrane Transport Proteins ,Analysis of Variance ,Membrane Glycoproteins ,Polymorphism, Genetic ,biology ,business.industry ,Case-control study ,Membrane Transport Proteins ,Temporomandibular Joint Dysfunction Syndrome ,medicine.disease ,Case-Control Studies ,biology.protein ,Female ,Gene polymorphism ,Carrier Proteins ,business ,Somatization - Abstract
The purpose of this study was to evaluate the relationship between temporomandibular joint pain and dysfunction and serotonin transporter (5-HTT) gene polymorphism. Forty-eight patients with temporomandibular joint pain and 111 healthy control subjects were examined. The results for the patients and control subjects were not significantly different (P >.05). The analysis of genotype distribution (homozygous for STin 2.10 genotypes of the variable-number tandem-repeat polymorphism) showed significant differences between the patients and control subjects (P =.003). ST 2.10 allele was more frequent in the patients with temporomandibular joint pain and dysfunction. In the control group, however, STin 2.12/12 genotype was significantly higher (P =.017). In the patients who were homozygous or heterozygous for variable-number tandem-repeat variants of 5-HTT STin 2.12 copies, the average scores of somatization and anger were significantly higher than those who were homozygous for STin 2.10 variant (P
- Published
- 2001
47. Serum IL-1β , sIL-2R, IL-6, IL-8 and TNF-α in schizophrenic patients, relation with symptomatology and responsiveness to risperidone treatment
- Author
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Hasan Herken, Ayse Binnur Erbagci, Oya Koyluoglu, Mehmet Tarakcioglu, and Necat Yilmaz
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Exacerbation ,medicine.medical_treatment ,Immunology ,Adjuvants, Immunologic ,Internal medicine ,Brief Psychiatric Rating Scale ,medicine ,lcsh:Pathology ,Humans ,Interleukin 6 ,Aged ,Risperidone ,biology ,Interleukin-6 ,Tumor Necrosis Factor-alpha ,business.industry ,Interleukin-8 ,Case-control study ,Interleukin ,Receptors, Interleukin-2 ,Cell Biology ,Middle Aged ,medicine.disease ,Endocrinology ,Cytokine ,Schizophrenia ,Case-Control Studies ,biology.protein ,Female ,business ,Research Article ,Antipsychotic Agents ,Interleukin-1 ,medicine.drug ,lcsh:RB1-214 - Abstract
Activation of the inflammatory response system and varied levels of cytokines in acute schizophrenia have been suggested by recent studies. Psychopharmacologic agents can differentially effect cytokine production, which suggests that therapeutic function of neuroleptics may involve immunomodulation.The present study was carried out to examine: (i) serum concentrations of interleukin (IL)-1β , soluble interleukin-2 receptor (sIL-2R), IL-6, IL-8 and tumour necrosis factor (TNF)- α in schizophrenic patients; (ii) their relation with psychopathological assessment; and (iii) the relation of the initial cytokine levels with responsiveness to risperidone therapy.Thirty-four drug-free schizophrenic patients with acute exacerbation and 23 age- and gender-matched healthy controls were recruited for this study. Psychopathological assessments at admission and throughout risperidone treatment for 60 days were recorded. Serum cytokine concentrations were determined with chemilumunescence assays.According to our results, serum IL-1β , sIL-2R, IL-6, IL-8 and TNF-α concentrations adjusted for age, gender, body mass index and smoking were no different in patients with schizophrenia and controls and among subtypes of schizophrenia. However, the initial TNF-α concentrations had a significant effect on Brief Psychiatric Rating Scale and Scale Assessment of Positive Symptoms scores. The initial cytokine concentrations of the patients responsive to risperidone were not significantly different from those of non-responsive patients.The present study demonstrates that plasma levels of IL-1β , sIL-2R, IL-6, IL-8 and TNF-α adjusted for confounding factors are not altered in drug-free schizophrenic patients at acute exacerbation. We suggest that, if cytokine production is altered in schizophrenia, these alterations may not be detectable in systemic circulation. According to our results, the therapeutic effect of risperidone is not related to basal levels of the aforementioned cytokines. However, serum TNF-α may contribute to symptomatology in schizophrenia.
- Published
- 2001
48. Significance of serotonin transporter gene polymorphism in migraine
- Author
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M. Emin Erdal, Osman Çataloluk, Mustafa Yilmaz, Hasan Herken, Ömer Barlas, and Yildirim Bayazit
- Subjects
Adult ,Male ,medicine.medical_specialty ,Turkey ,genetic structures ,Migraine Disorders ,Nerve Tissue Proteins ,behavioral disciplines and activities ,Central nervous system disease ,Polymorphism (computer science) ,Internal medicine ,medicine ,Humans ,Genetic Predisposition to Disease ,Allele ,Family history ,Alleles ,Serotonin transporter ,Serotonin Plasma Membrane Transport Proteins ,Membrane Glycoproteins ,Polymorphism, Genetic ,biology ,business.industry ,Membrane Transport Proteins ,Middle Aged ,medicine.disease ,Endocrinology ,Neurology ,Migraine ,biology.protein ,Female ,Neurology (clinical) ,Serotonin ,Gene polymorphism ,Carrier Proteins ,business - Abstract
Objective . To elucidate significance of the serotonin transporter gene (STG) polymorphism in migraine, and to address the polymorphic patterns of STG, both in the migraineurs and healthy people in this country. Study design . A PCR study of STG in 52 migraineurs and 80 healthy controls. Methods . Using the PCR technique, STG polymorphism was studied in the DNA obtained from leukocytes of the patients and healthy controls. Polymorphism of the two regions (VNTR and 5-HTTLPR) of STG was assessed. Results . VNTR STin 2.10 and STin 2.12 alleles were detected in migraineurs and healthy controls. Both homozygous and heterozygous STin 2.10 allele predominated in the migraine group ( p =0.01), while STin 2.12 allele was more frequent in the healthy controls ( p =0.02). There was no relationship between the migraine type, family history of migraine and STG polymorphism. Conclusion . STin 2.10 and STin 2.12 alleles of VNTR are frequent in this country. While the presence of STin 2.10 allele increases the risk of migraine, 5-HTTLPR polymorphism is not associated with this risk.
- Published
- 2001
49. Evidence that the activities of erythrocyte free radical scavenging enzymes and the products of lipid peroxidation are increased in different forms of schizophrenia
- Author
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Sadik Sogut, Osman Virit, Efkan Uz, Omer Akyol, Huseyin Ozyurt, and Hasan Herken
- Subjects
Adult ,Male ,medicine.medical_specialty ,Erythrocytes ,Antioxidant ,Adolescent ,medicine.medical_treatment ,medicine.disease_cause ,Thiobarbituric Acid Reactive Substances ,Superoxide dismutase ,Lipid peroxidation ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Internal medicine ,medicine ,TBARS ,Humans ,Molecular Biology ,chemistry.chemical_classification ,Glutathione Peroxidase ,biology ,Superoxide Dismutase ,Glutathione peroxidase ,Free Radical Scavengers ,Middle Aged ,Catalase ,Psychiatry and Mental health ,Red blood cell ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Biochemistry ,Schizophrenia ,biology.protein ,Female ,Lipid Peroxidation ,Oxidative stress - Abstract
In order to examine antioxidant status and lipid peroxidation in schizophrenia patients, activities of three free radical scavenging enzymes (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT)), and the level of thiobarbituric acid-reactive substances (TBARS) as an index of lipid peroxidation have been studied in red blood cells. Schizophrenic patients were divided into three groups (disorganized (n = 21), paranoid (n = 26) and residual types (n = 18)) to determine differences between subgroups. SOD, CAT and GSH-Px activities in the control group were found to be 1461.0 +/- 248.6 U g(-1) Hb, 148.2 +/- 59.3 k g(-1) Hb and 25.87 +/- 4.25 U g(-1) Hb, respectively. We found no significant differences in SOD activities between study and control groups. There was a significant increase in SOD activity in the residual group compared to the paranoid group (P < 0.005). CAT activity was found to be increased in disorganized (148%), paranoid (147%), and residual (165%) groups compared to the control group. GSH-Px activity was markedly increased in the study groups except the paranoid group. Statistically significant (3-4 fold) increases in TBARS levels of red blood cells were found in all the study groups. It is proposed that antioxidant status may be changed in schizophrenia and thus may induce lipid peroxidation. Therefore, oxidative stress may have a pathophysiological role in all the subtypes of schizophrenia.
- Published
- 2000
50. Jaundice and hepatic enzyme induction during lamotrigine therapy in a bipolar II patient
- Author
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H. Serdar Gergerlioglu, Hasan Herken, Salih Selek, Hamdi Tutkun, Haluk A. Savaş, and Esen Savas
- Subjects
Drug ,medicine.medical_specialty ,business.industry ,media_common.quotation_subject ,Jaundice ,Lamotrigine ,medicine.disease ,Discontinuation ,Psychiatry and Mental health ,Bipolar II disorder ,Mood ,Cholestasis ,medicine ,Bipolar disorder ,medicine.symptom ,business ,Psychiatry ,media_common ,medicine.drug - Abstract
Lamotrigine is a novel mood stabiliser as well as an anti-epileptic drug that has already been used for the prevention of convulsions. Despite several known side effects, hepatic dysfunction related to the drug has not been widely reported. A few cases have been observed in neurological, especially paediatric patients, but not in psychiatric patients. We report a case of cholestatis which occurred 6 weeks after starting lamotrigine therapy and which resolved after discontinuation, during the acute phase of disease. To the best of our knowledge, this is the first case of lamotrigine associated with cholestasis reported in patients with bipolar disorder.
- Published
- 2005
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