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23 results on '"Haruhiko TOKUOMI"'

1. Histochemical studies of lysosomal enzyme and nitroblue tetrazolium reduction of phagocytes in the cerebrospinal fluid of patients with infectious diseases of the central nervous system

Author

Toru Ideta, Masayuki Ando, Koji Imanishi, and Haruhiko Tokuomi

Subjects
Pathology, medicine.medical_specialty, Acid Phosphatase, Central nervous system, Inflammation, Biology, Infections, Tuberculous meningitis, chemistry.chemical_compound, Cerebrospinal fluid, Central Nervous System Diseases, medicine, Humans, Cerebrospinal Fluid, chemistry.chemical_classification, Phagocytes, Histocytochemistry, Nitroblue Tetrazolium, Acid phosphatase, General Medicine, beta-Galactosidase, medicine.disease, medicine.anatomical_structure, Enzyme, Neurology, chemistry, Immunology, biology.protein, Neurology (clinical), medicine.symptom, Subarachnoid space, Formazan, Lysosomes, Oxidation-Reduction
Abstract

Lysosomal enzyme levels and nitroblue tetrazolium (NBT) reduction of phagocytes in the cerebrospinal fluid (CSF) of patients with infectious diseases of the central nervous system (CNS) were studied histochemically to evaluate the function of phagocytes. Lysosomal enzymes of acid phosphatase and β-galactosidase were demonstrated in mononuclear phagocytes and leptomeningeal cells, but not in polymorphonuclear leukocytes (PMN) and lymphocytes. In tuberculous meningitis, more than 60% of the cells were positive for the enzymes as compared with less than 30% for other diseases. Besides, the cells which stained highly for the enzymes were often found in the CSF of tuberculous meningitis. The lysosomal enzyme levels in the cells were dependent on the nature of the infection rather than on the intensity of inflammation when judged by total cell count in the CSF. On the other hand, reduced NBT formazan was found in PMN, mononuclear phagocytes, and leptomeningeal cells. The intensity of NBT reduction by these cells correlated well with the total cell count in CSF; i.e., enhanced NBT reduction by phagocytes reflected the intensity of the inflammation in the subarachnoid space. Thus, histochemical study of phagocytes in CSF can provide useful additional aids to the diagnosis of the nature and stage of CNS infection.

Published
2009
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3. PULMONARY FUNCTION IN PROGRESSIVE MUSCULAR DYSTROPHY

Author

Toshiaki Yasutake, Toru Ideta, Sadaaki Okamoto, Koji Sato, Gen Kimura, Masayuki Ando, Toru Okajima, Teruhisa Ozaki, Yasutsugu Fukuda, Koji Imanishi, Haruhiko Tokuomi, Mineharu Sugimoto, and Kiyoshi Shima

Subjects
medicine.medical_specialty, business.industry, Internal medicine, medicine, Cardiology, General Medicine, Muscular dystrophy, medicine.disease, business, Pulmonary function testing
Abstract

進行性筋ジストロフィー症は,その本態の究明が急がれている疾患の一つである.臨床的には,なかんずく,肺不全による死亡率は高く,呼吸機能について,さらに充分な検討がなされなければならないと考え, 8～18才の進行性筋ジストロフィー症患者18例を対象に,その換気機能と動脈血ガス分析を, 3年間に亘り経時的に観察をつづけてきた.その結果,換気機能では,拘束性障害を示し,次第に進行していた.その肺気量分画では,残気量の増加と予備呼気量の減少がとくに目立ち,残気率は次第に増大していた.また1回換気量も比較的小さく,死腔を考慮に入れると,有効肺胞換気量が充分だとは思えなかつた.これらの換気障害にもかかわらず,動脈血ガス分圧はほぼ正常範囲にあり,この両者は,一見矛盾する様にみえる.しかし,進行性筋ジストロフィー症では,単位時間当りの酸素消費量と炭酸ガス産生量が,共に低い状態に維持されているためであると理論的に推測することによつて,実際には,両者が矛盾していないことを示した.

Published
1975
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4. Pharmacological studies of the pupils in familial amyloid polyneuropathy

Author

Kazuko Hatamoto, Yoshio Takaba, Yoshimi Kinoshita, Toru Okajima, Haruhiko Tokuomi, and Jinro Nagata

Subjects
Adult, Male, Sympathetic nervous system, medicine.medical_specialty, Pathology, Epinephrine, Tyramine, Lesion, Internal medicine, medicine, Humans, Methacholine Compounds, Clinical Trials as Topic, business.industry, Peripheral Nervous System Diseases, Pupil, Amyloidosis, Middle Aged, Peripheral, medicine.anatomical_structure, Neurology, Cardiology, Amyloid polyneuropathy, Female, Methacholine, Neurology (clinical), medicine.symptom, business, medicine.drug
Abstract

Pharmacological studies of the pupils of 7 patients with familial amyloid polyneuropathy (FAP) were performed in order to demonstrate the site of the lesion. Supersensitivity to 1.25% epinephrine was observed frequently, but not to 2.5% methacholine. The lesions of the sympathetic nervous system, judging from the epinephrine and tyramine tests, were regarded as preganglionic in 2 patients and postganglionic in 4. Among 3 patients reexamined six months later, 1 had developed signs of sympathetic postganglionic disturbance and another showed a peripheral parasympathetic disturbance associated with progress of a sympathetic preganglionic disturbance. From these results it was suggested that in FAP, sympathetic abnormalities involve the pupils more often than parasympathetic disturbances, and pharmacological studies can detect the autonomic dysfunction before it becomes clinically apparent.

Published
1978
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5. Studies on the respiratore infection in patients with lung cancer

Author

Kastumasa Tokunaga, Haruhiko Tokuomi, Kiyoshi Shima, Yasustugu Fukuda, and Manabu Rokutanda

Subjects
Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, business.industry, Internal medicine, Medicine, In patient, business, Lung cancer, medicine.disease
Abstract

肺癌121例につき, 肺感染症の合併に関して, 細菌学的並びに免疫学的検討を行なった. 肺感染合併率は38.0%で, 原発性肺癌への合併が33.9%, 転移性肺癌へのそれが4.1%で, このうち類上皮癌との合併が54.8%と感染の合併が高かった. 起炎菌は, グラム陰性菌が76.6%と大半を占め, そのうちでも肺炎桿菌, 緑膿菌が多かった. 白血球T, B細胞および単球・多核球の酵素活性を検索した結果, 対照に比し低下を認め, かつ感染の有無との間に甚しい差が認められなかった. かゝる事実から感染の無い症例でも易感染性を有しているものと推定された.

Published
1976
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6. AN AUTOPSY CASE OF CHRONIC CHAGAS' DISEASE

Author

Yoichi Hokamura, Yutaka Horio, Yuko Saito, Koichiro Kataoka, Tadahiro Ono, Hirotada Katsuya, Hiroshi Nakao, and Haruhiko Tokuomi

Subjects
Pediatrics, medicine.medical_specialty, business.industry, Chronic Chagas' disease, Medicine, General Medicine, Autopsy case, business
Abstract

慢性Chagas病は本邦にて,未だその報告を見なかつたが,最近,我々は本病の1例を経験したので,ここに報告する.症例は62才,男性で, 21才時ブラジルに移住し農薬に從事していた.数年前より動悸,呼吸困難を自覚し,強心剤,利尿薬の投与を受けていた.入院前1週間頃より,夜間呼吸困難,動悸を自覚し,昭和52年7月20日に入院した.入院時は,毎分100の絶対性不整脈,心拡大,肺野ラ音,頚部静脈怒張,肝腫大,下腿浮腫を認め,重症うつ血性心不全の状態であつた.心電図上は,心房細動,右脚ブロック型心室内伝導障害を有しており,ジギタリス薬投与にて多源性心室性期外収縮の頻発を認めたので,電気的除細動を行ない洞調律に復した.心臓超音波検査にても,左心室後壁のAkinesiaと低心拍出性心不全の状態を呈していた.ブラジルでのMachado-Guerreiro補体結合反応陽性にて,慢性Chagas病と診断した.本例の重症うつ血性心不全はジギタリス薬,利尿薬などに抵抗性であつた.死亡前日より,心室頻拍の発作が頻回出現し, 38病日には,心室細動にて死亡した.死後剖検にて,心重量は740gであつた.組織学的には慢性間質性心筋炎と心筋線維内にTrypanosoma cruziのleishmaniaの巣が認められた.

Published
1979
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7. Clinical Studies on KW-1062

Author

Minoru Yokoyama, Otohiko Kunii, Shiro Miwa, Yohmei Hiraga, Keimei Mashimo, Seiki Okamura, Hiroyuki Kobayashi, Nobuo Maekawa, Mitsuo Obana, Hideo Sasaki, Takahashi Isao, Osamu Kurimura, Haruhiko Tokuomi, Keiichi Nakagawa, Yoshiji Yamane, Osamu Kitamoto, Mitsuhiko Kuroda, Ryohyuh Takeda, Akio Aoyagi, Kohki Hoshikawa, Kazue Tamaki, Norio Kikuchi, Kohji Kikuchi, Izumi Hayashi, Michiyasu Nakanishi, Yasuko Haneda, Kaoru Ohyama, Osamu Sekine, Tadashi Takigami, Ippei Fujimori, Kazuo Takebe, Kazufuto Fukaya, Ken-ichi Imamura, Shohhei Watanabe, Yasutsugu Fukuda, Sumio Yamaoka, Mamoru Yumita, Kenji Mitsui, and Katsumasa Tokunaga

Subjects
Engineering, business.industry, Library science, General Medicine, business
Published
1980
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9. Comparison of DL-8280 and Amoxicillin in the Treatment of Respiratory Tract Infections

Author

Hiroyuki KOBAYASHI, Kenji TAKAMURA, Kota KONO, Sokichi ONODERA, Nobuhiro SASAKI, Fumio NAGAHAMA, Yoshikazu KAWAKAMI, Yukihiko HONMA, Michiyuki MATSUZAKI, Kazunori TANIMURA, Mikio INOUE, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Yomei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Kazuo TAKEBE, Tomio ONUMA, Toyokazu TAMURA, Shuichiro YOSHIDA, Shigeru OCHIAI, Katsutoshi KARIYA, Akiko YAMANAKA, Naoyoshi MASAKI, Katsuhiro OKAMOTO, Masao TAMURA, Takashi ITO, Yoshikatsu NEMOTO, Seiki SATOH, Shiroh IDA, Tamotsu TAKISHIMA, Kiyoshi KONNO, Kotaro OIZUMI, Seiichi AONUMA, Izumi HAYASHI, Tatsuya ABE, Teruo AOYAGI, Yuichi KOIZUMI, Masataka KATSU, Masanori ADACHI, Hajimu TAKEDA, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Isao NITTA, Kyoko WATANABE, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Atsushi SAITO, Kohya SHIBA, Tadashi MIYAHARA, Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Ko FUKUI, Keimei MASHIMO, Yoshiji YAMANE, Kazuaki HANAOKA, Hiroichi TANIMOTO, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Ryuo NAKATANI, Koichiro NAKATA, Hideo IKEMOTO, Kazuyoshi WATANABE, Kaoru SHIMADA, Kyoko URAYAMA, Takashi INAMATSU, Yuzo FUNATSU, Fuyuhiko HIGASHI, Takao TAKIZAWA, Jun TAMAOKI, Junzaburo KABE, Hiroyoshi ISHIBASHI, Masako KATO, Toshio ITO, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Shigeki ODAGIRI, Hirotada IKEDA, Kaneo SUZUKI, Kou MUROHASHI, Tamotsu KANEKO, Kazufuto FUKAYA, Fumio MATSUMOTO, Kaoru OYAMA, Kuninori SUZUKI, Kaoru SHIMOKATA, Keisuke NISHIWAKI, Shuzo SAKAI, Masanori MORISE, Yasunobu TOTANI, Masahito KATO, Toshihiko TAKEUCHI, Hidekazu HANAKI, Saburo KITAURA, Toshiyuki YAMAMOTO, Katsutaka TORIKAI, Yoichi ABE, Nobuo MAEKAWA, Michiyasu NAKANISHI, Takekuni IWATA, Kazukiyo OIDA, Ryoichi AMITANI, Yoshiro MOCHIZUKI, Yoshio TAGUCHI, Nobuo INABA, Yoshiro ODA, Akira KAGIOKA, Hiroyuki TSUJINO, Hitoshi NAKAI, Kyosuke ISHIHARA, Hiroko SAKAMOTO, Yoko YAMAGATA, Fumio MIKI, Kenji TAKAMATSU, Yuruko OKAMOTO, Keigo MAEHARA, Muneto YOSHIOKA, Yube IIDA, Kohjiro YASUNAGA, Hiroshi OKUBO, Yoshihiro UEDA, Rinzo SOEJIMA, Yoshito NIKI, Chikara NAKAHAMA, Masatoshi WATANABE, Jiro HINO, Osamu KURIMURA, Yoshihiko ARATANI, Hideo SASAKI, Hirofumi FUKUHARA, Yukio NISHIMOTO, Michio YAMAKIDO, Keiko IWAMOTO, Naomi KODOMARI, Eiro TSUBURA, Masakazu TAMURA, Hidetoshi OHGUCHI, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Hitoshi NAGANO, Hideto TSURUTANI, Reiko KISHIKAWA, Takashi ITOGA, Masaru NASU, Jun GOTO, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Koichi WATANABE, Masamoto NAKANO, Akira IKEBE, Makoto Ishizaki, Tsunetoshi KOTEDA, Keizo MATSUMOTO, Harumi SHISHIDO, Kunio KUDO, Hisao KIMURA, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Yasutsugu FUKUDA, Katsumasa TOKUNAGA, Haruhiko TOKUOMI, Kiyoshi SHIMA, Sadanobu HIGUCHI, Shinobu TAKENAKA, Kazumine KOBARI, Masao NAKATOMI, and Yuei IRABU

Subjects
Adult, Male, Ofloxacin, medicine.medical_specialty, Haemophilus Infections, Gastroenterology, Anti-Infective Agents, Double-Blind Method, Internal medicine, Oxazines, medicine, Humans, Pseudomonas Infections, Bronchitis, Respiratory Tract Infections, Aged, Clinical Trials as Topic, Respiratory tract infections, business.industry, Amoxicillin, Pneumonia, General Medicine, Middle Aged, Bronchiectasis, Female, business, medicine.drug
Published
1984
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10. Comparative Study of the Effectiveness of Cefotaxime and Cefazolin on Respiratory Tract Infection

Author

Tadashi Miyazawa, Yoshihiro Ueda, Toshio Fujioka, Seiichi Honma, Kaoru Oyama, Yasutoshi Suzuki, Takehito Nakamura, Shiro Kosaka, Tsukasa Yoshida, Mitsunobu Akashi, Takashi Watanabe, Tadashi Miyahara, Ryoji Ohashi, Tamotsu Takishima, Akio Aoyagi, Fumio Miki, Kohei Hara, Shinichi Morinaga, Koya Shiba, Morikuni Abe, Gen Tajima, Okui S, Fumio Nagahama, Yasutsugu Fukuda, Kosuke Nakazawa, Takamitsu Kido, Shuichiro Yoshida, Susumu Suetsugu, Kuninori Suzuki, Kazuki Miura, Makoto Imaoka, Teruo Katayama, Keiko Cho, Masahito Okayasu, Takashi Ito, Toshio Hojyo, Michiyasu Nakanishi, Mitsuo Nakamura, Masumi Tomizawa, Kotaro Oizumi, Hironobu Ihara, Ryutaro Kiuchi, Nobuki Aoki, Kiyoshi Konno, Yoichiro Ichikawa, Masanaga Takato, Jingoro Shimada, Tsuneo Tsutsumi, Yoshito Niki, Ryuzo Fueki, Koichi Watanabe, Masayuki Ando, Takehumi Kunieda, Kenji Kubo, Keisuke Nishiwaki, Yoshio Kobayashi, Yasuo Nomura, Ko Fujii, Takekuni Iwata, Masatoshi Ide, Harumi Shishido, Nobuharu Oe, Yoshio Hoshihara, Sumio Yamaoka, Yoji Suzuyama, Takehisa Yamaji, Kazuhiko Hagane, Kazuo Sasaki, Koichiro Nakada, Shuzo Sakai, Katsuhiro Okamoto, Hiromi Asakura, Yoshioki Niwa, Toshiyuki Yamamoto, Mitsuru Iwakura, Kazue Sadamoto, Rinzo Soejima, Kosho Yoshikawa, Keiichi Nakagawa, Tatsuo Suzuki, Yukio Nishimoto, Kunio Kudo, Yoshihiro Kumasaka, Yoshio Kinoshita, Masataka Katsu, Tadashi Takigami, Yoshimaru Usuda, Hiroshi Okubo, Hisao Kimura, Kaoru Okada, Shinichi Matsuo, Hiroichi Tanimoto, Akira Saito, Osamu Sekine, Ippei Fujimori, Kaoru Shimada, Akio Tachibana, Katsuhiko Matsui, Yomei Hiraga, Hisashi Nakahata, Izumi Hayashi, Yoshiteru Shigeno, Noboru Shimizu, Masahisa Omori, Kenichi Kimura, Hiromi Kato, Atsushi Saito, Yoshihiko Matsuda, Rokushi Oka, Michio Yamakido, Masahito Kato, Eiro Tsubura, Otohiko Kunii, Shigeru Miyano, Akira Ujiie, Atsushi Shimomura, Hiroshi Nagano, Toshiro Oda, Jutaro Shimomura, Kazuo Horie, Haruhiko Tokuomi, Shoko Narita, Kazuo Takebe, Keiji Takahashi, Mitsuko Takamura, Kazufuto Fukaya, Ken-ichi Imamura, Masao Nakatomi, Keigo Maehara, Masaru Nasu, Toshiyuki Maeda, Katsumasa Tokunaga, Yasuo Matsuoka, Shoji Yasui, Tsuneo Matsubara, Ryokichi Takasugi, Hajimu Takeda, Kenzo Shiota, Takafumi Yano, Kiyoya Izumi, Shigeru Nagaoka, Genichi Tanaka, Hiroshi Okano, Tetsuaki Inokuchi, Kozo Mori, Yasushi Yamada, Seiichi Murakami, Osamu Kitamoto, Makoto Fukui, Shinya Yasuda, Yasumichi Kato, Hideo Ikemoto, Fumihiko Uba, Mitsuaki Yoshioka, Yasuhiro Kawabe, Hirohiko Nagasaka, Hiromichi Umeda, Hiroyuki Kobayashi, Keizo Matsumoto, Nobuaki Tsuzuki, Yoshiro Sawae, Takeshi Mashima, Toshikatsu Kato, Tomohiro Kanazawa, Sumio Arai, Kiyohito Takahashi, Kiyofumi Ishikawa, Junzaburo Kabe, Keimei Mashimo, Setsuo Kobayashi, Norio Kihara, Toshihiko Yoshiga, Shigechika Kado, Hideo Sasaki, Fusanosuke Yamasaku, Kazuhiko Ito, Mikihiko Kudo, Saburo Yano, Yuruko Okamoto, Tsunetoshi Koteda, Nobuo Maekawa, Masanori Morise, Masaro Kaji, Kazuyoshi Watanabe, Yoshihiro Takishita, Masanori Adachi, Yoshihiko Tano, Yasuko Yuasa, Kinichi Izumikawa, Hideyo Noguchi, and Osamu Kurimura

Subjects
medicine.anatomical_structure, Cefotaxime, business.industry, Anesthesia, Cefazolin, medicine, General Medicine, business, medicine.drug, Respiratory tract
Published
1980
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11. Comparative Clinical Study of Cefpiramide (SM-1652) and Cefmetazole for Respiratory Tract Infections by a Double-Blind Method

Author

Hiroyuki KOBAYASHI, Osamu KITAMOTO, Akira SAITO, Yasumichi KATO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Morikuni ABE, Akira UJIIE, Yoshio KINOSHITA, Osamu YAJIMA, Fumio NAGAHAMA, Yuichi SASAKI, Shinya YASUDA, Takehito NAKABAYASHI, Takahisa SAITO, Satoshi YAGUCHI, Kazuo SAOTOME, Yuji IKEDA, Jutaro SHIMOMURA, Mitsuharu OGI, Hiroshi TAKAGI, Akihiko KUZE, Osamu MITSUHASHI, Takashi TAKABORI, Yomei HIRAGA, Kohki KIKUCHI, Hiroshi KAWAI, Kazuo TAKEBE, Kenichi IMAMURA, Yoshihiro KUMASAKA, Kiyohito TAKAHASHI, Hisashi NAKAHATA, Mitsuo NAKAMURA, Takashi CHINOI, Katsuhiro OKAMOTO, Shuichiro YOSHIDA, Naoyoshi MASAKI, Toyokazu TAMURA, Tadashi MIYAZAWA, Hazime WATANABE, Shiro KOSAKA, Makoto NAKAZONO, Tsuneharu BABA, Kazuo SASAKI, Morio SAGARA, Hitoshi YASHIRO, Osamu UEHARA, Masao TAMURA, Ryuji ITO, Taro CHIBA, Kazuki KONISHI, Toshimi SUZUKI, Yoshiaki TAKEZAWA, Yasuo ONO, Hisao KIMURA, Tamotsu TAKISHIMA, Kiyoshi KONNO, Kotaro OIZUMI, Akira WATANABE, Seiichi AONUMA, Kikuo ONUMA, Izumi HAYASHI, Tatsuya ABE, Masataka KATSU, Kenichi OKAYAMA, Kunio IMATAKA, Masanori ADACHI, Fuyuhiko HIGASHI, Hideo IKEMOTO, Kazuyoshi WATANABE, Junko HIBINO, Yasushi UEDA, Atsushi SAITO, Masanobu KAJI, Tadashi MIYAHARA, Ryozo YONEDA, Mitsuo KAWAMURA, Sumio YAMAOKA, Keimei MASHIMO, Keiichi NAKAGAWA, Masaru KOYAMA, Kentaro WATANABE, Motoichi TANAKA, Shinichi ODAMA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Hiroichi TANIMOTO, Akio TACHIBANA, Ippei FUJIMORI, Michinori KOHNO, Yoshio KOBAYASHI, Toshio FUKUI, Kenji MITSUI, Kokichi FUKUSHIMA, Akira ITHO, Kunihiko SHINDO, Shigeki ODAGIRI, Makio KURIHARA, Hideyuki HASEGAWA, Kazufuto FUKAYA, Hajimu TAKEDA, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Kaoru OHYAMA, Kuniyoshi SUZUKI, Ryusaku SHIMIZU, Toshiyuki YAMAMOTO, Saburo KITAURA, Masahito KATO, Kenzo SUZUKI, Kazuo YOSHITOMO, Motoko YAMAMOTO, Akihiko KISHIMOTO, Nobuo MAEKAWA, Michiyasu NAKANISHI, Takekuni IWATA, Mitsuo HASE, Ryoichi AMIYA, Yoichi OSADA, Hiroshi OKUBO, Yuruko OKAMOTO, Yoshihiro UEDA, Keigo MAEHARA, Fumio MIKI, Rinzo SOEJIMA, Yoshito NIKI, Masayasu KAWANISHI, Chikara NAKAHAMA, Yukio NISHIMOTO, Michio YAMAKIDO, Fumiaki TSUKIYAMA, Osamu KURIMURA, Hideo SASAKI, Yoshihiko ARAYA, Yoko KAGAWA, Eiro TSUBURA, Toshihiro GOTO, Yoshihiro TAKISHITA, Yoshiro SAWAE, Kaoru OKADA, Nobuaki SHIGEMATSU, Osamu OGUSHI, Kohei HARA, Tsuneo TSUTSUMI, Kazuhiro OKUNO, Rokushi OKA, Keizo YAMAGUCHI, Youji SUZUYAMA, Toshiyuki OE, Yoshiteru SHIGENO, Naomi ITOH, Hikaru TANAKA, Masao SAI, Keizo MATSUMOTO, Harumi SHISHIDO, Tsuneo ISHIBASHI, Masahiro TAKAMOTO, Atsushi SHINODA, Hitoshi NAGANO, Toshiyuki HAYASHI, Haruhiko TOKUOMI, Yasutsugu FUKUDA, and Katsumasa TOKUNAGA

Subjects
Double blind, Clinical study, medicine.medical_specialty, Respiratory tract infections, business.industry, Internal medicine, medicine, General Medicine, Cefpiramide, Cefmetazole, business, Gastroenterology, medicine.drug
Published
1983
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12. Comparative Test of the Effectiveness of Cefoperazone (T-1551) and Cefazolin (CEZ) on Respiratory Tract Infection by Double Blind Method (II)

Author

Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Norio KIHARA, Tatsuo SUZUKI, Akira FUKUI, Yasumichi KATO, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Yoshio KINOSHITA, Kiyofumi ISHIKAWA, Fumio NAGAHAMA, Takehito NAKABAYASHI, Shinya YASUDA, Tetsuji KOROKU, Takahisa SAITO, Kazunori HARADA, Hiroshi KON, Takashi MIKAMI, Nobuo WATANABE, Yasumasa YOKOTA, Toshio KIRISAWA, Akira NAKASATO, Akira SASAKI, Masataka ITO, Ryuji SATO, Kazuo TAKEBE, Yoshihiro KUMASAKA, Hisashi NAKAHATA, Shiro KOSAKA, Mitsuo NAKAMURA, Kenichi IMAMURA, Koji MACHIDA, Kazuo SASAKI, Katsuhiro OKAMOTO, Shuichiro YOSHIDA, Hiroyasu KAWABE, Mitsuaki YOSHIOKA, Shokou NARITA, Masahiro TSUTSUI, Tamotsu TAKISHIMA, Sumio ARAI, Kazuki KONISHI, Tadashi TAIMA, Nobuo SATO, Hajime TAKEDA, Masatoshi NIWAYAMA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Yasuko YUASA, Izumi HAYASHI, Masataka KATSU, Mieko KAWAI, Teruo AOYAGI, Noboru YANAI, Iwao TAKANAMI, Masashi MOURI, Otohiko KUNII, Kazufuto FUKAYA, Yasushi UEDA, Atsushi SAITO, Jingoro SHIMADA, Masahisa OOMORI, Kooya SHIBA, Takehisa YAMAJI, Hironobu IHARA, Toshio HOJO, Tadashi MIYAHARA, Hiroichi TANIMOTO, Akio TACHIBANA, Koichiro NAKADA, Mikizo SUZUKI, Kaoru SHIMADA, Takashi INAMATSU, Kyoko URAYAMA, Keimei MASHIMO, Sumio YAMAOKA, Junzaburo KABE, Osamu KITAMOTO, Hiroyuki KOBAYASHI, Hideo IKEMOTO, Ikko WATANABE, Terumi TAKAHASHI, Touji ODAGIRI, Ippei FUJIMORI, Yasuo MASTUOKA, Yoshio KOBAYASHI, Kojiro SEKITA, Kenji MITSUI, Kokichi FUKUSHIMA, Akira ITO, Hideyuki HASEGAWA, Koichi YAMANAKA, Kunihiko SINDO, Ryuichiro YAMASAKI, Makio KURIHARA, Takashi SUYAMA, Raiji YAMAMOTO, Yukihiko OBIGANE, Shizuo ABE, Tadashi TAKIGAMI, Kaoru OYAMA, Kuninori SUZUKI, Masao KUROSAKI, Mitsuru HAYASE, Nobuo OOYA, Toshiyuki YAMAMOTO, Masahito KATO, Hirohiko NAGASAKA, Kozo MORI, Saburo KITAURA, Kunio NANJO, Joichi KATO, Nobuo MAEKAWA, Michiyasu NAKANISHI, Nobuo INABA, Yoshiro ODA, Kenzo SHIOTA, Fumio MIKI, Akira OKUBO, Yuruko OKAMOTO, Fumihiko UBA, Yoshihiro UEDA, Keigo MAEHARA, Rinzo SOEJIMA, Toshiharu MATSUSHIMA, Yoshihiko TANO, Yoshito NIKI, Susumu YAGI, Hironori HARA, Kyosei SODA, Naomi KIMURA, Takanobu MATSUMOTO, Hiroshi SEWAKE, Mitsue NISHIMURA, Mikio HAYAKAWA, Hiromichi KUNIKI, Osamu KURIMURA, Kazue SADAMOTO, Hideo SASAKI, Eiro TSUBURA, Yoshihiro TAKISHITA, Toshihiro GOTO, Yoshiro SAWAE, Kaoru OKADA, Tsuneo ISHIBASHI, Masanori TAKAMOTO, Fumihiko MAEDA, Tetsuo FUJIKI, Minoru YOSHIDA, Hitoshi NAGANO, Shinichi MATSUO, Kohei HARA, Masao NAKATOMI, Masaru NASU, Tsuneo TSUTSUMI, Yoshiteru SHIGENO, Masaki HIROTA, Keizo MATSUMOTO, Harumi SHISHIDO, Hisao KIMURA, Kouichi YOKOYAMA, Masato HAYASHI, Chiyohiko SHINDO, Haruhiko TOKUOMI, Yasutsugu FUKUDA, Katsumasa TOKUNAGA, Kiyoshi SHIMA, and Teruya ICHIKI

Subjects
Cefoperazone, Chemistry, Anesthesia, Cefazolin, medicine, General Medicine, medicine.drug
Published
1980
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13. 3) ORGANIC MERCURY POISONING

Author

Haruhiko Tokuomi

Subjects
Toxicology, Minamata disease, Public discussion, chemistry, business.industry, Environmental chemistry, medicine, chemistry.chemical_element, General Medicine, medicine.disease, business, Organic mercury poisoning, Mercury (element)
Abstract

It has been proved that the Minamata disease is the poisoning by alkyl compound (AM), and recently phenyl mercury compounds (PM) which are used as agricultural drugs have been brought on public discussion. This report deals with clinical and experimental studies on these poisonings.

Published
1968
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14. Fisher's syndrome: A pharmacological study of the pupils

Author

Shoichiro Kawasaki, Haruhiko Tokuomi, Toru Ideta, Toru Okajima, and Shigehiro Imamura

Subjects
Sympathetic nervous system, Epinephrine, Tyramine, Pupil, Lesion, Parasympathetic nervous system, Cocaine, medicine, Pupillary response, Humans, Methacholine Compounds, Aged, Anisocoria, Ophthalmoplegia, Syndrome, eye diseases, medicine.anatomical_structure, Neurology, Pupillary reflex, Anesthesia, Ataxia, Female, Methacholine, Neurology (clinical), medicine.symptom, Psychology, medicine.drug
Abstract

A pharmacological study was performed in the involved pupils to demonstrate the site of lesion in a patient with Fisher's syndrome who showed marked ptosis, complete external ophthalmoplegia, pupillary involvement with anisocoria, facial paresis, ataxia, areflexia, and albuminocytological dissociation in the cerebrospinal fluid. The instillation of 2.5% methacholine produced mild constriction of one pupil. This response was not detectable in the recovery stage. The instillation of 1.25% l-epinephrine produced marked bilateral dilation of the pupils, in both the early and recovery stages. Instillation of 5% tyramine produced pupillary dilation as in the normal pupil. The response to 5% cocaine, tested only in the recovery stage, was weak in one pupil. These results imply that the pupillary involvement was due to peripheral involvement of the sympathetic and parasympathetic nervous systems. The lesion in the sympathetic nervous system was preganglionic, but in the parasympathetic nervous system the precise localization could not be determined.

Published
1977
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15. Adverse Effects of Atropine on the Sinus Node in Familial Amyloid Polyneuropathy

Author

Yoichi Hokamura, Toru Okajima, Yoshiaki Matsumoto, Haruhiko Tokuomi, Tadahiro Ono, and Yutaka Horio

Subjects
Adult, Atropine, Male, Pulmonary and Respiratory Medicine, Bradycardia, Critical Care and Intensive Care Medicine, medicine, Humans, Paresthesia, Adverse effect, Cycle length, Sinus (anatomy), Sinoatrial Node, business.industry, Sinoatrial node, Amyloidosis, Syndrome, medicine.disease, medicine.anatomical_structure, Anesthesia, Heart Function Tests, Amyloid polyneuropathy, medicine.symptom, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

Electrophysiologic studies were performed in a 33-year-old man with familial amyloid polyneuropathy (FAP) before and after administration of atropine, 1 mg intravenously. Atropine induced prolongation of the sinus node cycle length, sinoatrial conduction time, and sinus nodal recovery time. These findings indicate that the therapeutic doses of atropine may be useless or potentially detrimental for bradyarrhythmias or sinoatrial conduction disturbances in some patients with FAP.

Published
1982
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16. Minamata disease (organic mercury poisoning): neuroradiologic and electrophysiologic studies

Author

Ryoji Nakanishi, Shigehiro Imamura, Makoto Uchino, Hiroaki Yamanaga, Haruhiko Tokuomi, and Toru Ideta

Subjects
Adult, Male, medicine.medical_specialty, Minamata disease, Adolescent, Sensory system, Audiology, Cerebellar Diseases, Evoked Potentials, Somatosensory, Tremor, Medicine, Humans, Aged, business.industry, Diffuse atrophy, Brain, Postural tremor, Middle Aged, medicine.disease, Action tremor, Visual cortex, medicine.anatomical_structure, Somatosensory evoked potential, Mercury Poisoning, Female, Neurology (clinical), business, Tomography, X-Ray Computed, Organic mercury poisoning
Abstract

We studied 10 patients with Minamata disease (organic mercury poisoning) who have been followed for over 20 years. CT revealed a bilateral, symmetric, low-density area in the visual cortex and diffuse atrophy of the cerebellar hemispheres and vermis, especially the inferior vermis. Computerized quantitative analysis of the tremor of these patients showed a peculiar frequency of 7.075 Hz on postural tremor and 7.501 Hz on action tremor. On studies of short-latency somatosensory evoked potential, all patients showed a lack of the N20 component, the potential of the somatic sensory area.

Published
1982

17. Chronic sensory and autonomic neuropathy

Author

Hiroshi Ueno, Toru Okajima, Kazuhiro Hamada, Shoichiro Kawasaki, Tom Ideta, Haruhiko Tokuomi, and Sadamitsu Yamamura

Subjects
Male, medicine.medical_specialty, Nerve root, business.industry, Sensation, Dysautonomia, Sensory system, Sympathetic trunk, Middle Aged, medicine.disease, Orthostatic vital signs, medicine.anatomical_structure, Autonomic Nervous System Diseases, Internal medicine, Cardiology, Medicine, Sphincter, Humans, Neurology (clinical), medicine.symptom, Nervous System Diseases, business, Pure autonomic failure, Myenteric plexus
Abstract

A man with sensory neuropathy had evidence of autonomic failure: abnormal pupils, hypohidrosis, esophageal dilation, diarrhea, hypotension, orthostatic hypotension, sphincter disturbance, and impotence. Functional tests revealed abnormalities of both sympathetic and parasympathetic systems, mainly postganglionic. Autopsy revealed degeneration of posterior columns, posterior nerve roots, posterior root ganglia, and peripheral nerves. Degeneration was also observed in the sympathetic trunk, vagal nerve, and myenteric plexus. Neurons in the intermediolateral columns were preserved. Progressive sensory neuropathy with dysautonomia seems to be a new disease.

Published
1983

18. [Comparative study of TMS-19-Q and midecamycin for respiratory tract infection by double-blind method]

Author

Hiroyuki KOBAYASHI, Tomoko NIHEI, Hiroaki TAKEDA, Kohta KOHNO, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Yomei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Kazuo TAKEBE, Shiro KOSAKA, Teruo NAKAMURA, Shuichiro YOSHIDA, Masao TAMURA, Takashi ITO, Taro CHIBA, Ryoji OGATA, Kazuo TANIFUJI, Kotaro ITAKURA, Kiyoshi KONNO, Kotaro OIZUMI, Kosaku NAGAI, Izumi HAYASHI, Tatsuya ABE, Masataka KATSU, Shinji OKUI, Masanori ADACHI, Atsushi SAITO, Kohya SHIBA, Tadashi MIYAHARA, Tetsuro UGAI, Yoshiji YAMANE, Keimei MASHIMO, Keiichi NAKAGAWA, Masaru KOYAMA, Ryuji AKIYOSHI, Ichiro MURATA, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Fumio MATSUMOTO, Shigeki ODAGIRI, Hirotada IKEDA, Kaneo SUZUKI, Kou MUROHASHI, Tamotsu KANEKO, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Fusanosuke YAMASAKU, Kaoru OYAMA, Toshiyuki YAMAMOTO, Masahito KATO, Kunio NANJO, Motoko YAMAMOTO, Hidekazu HANAKI, Hirohiko NAGASAKA, Tsuyoshi ITO, Toshihiko TAKEUCHI, Masakazu KOHNO, Fumio MIKI, Kenji TAKAMATSU, Yuruko OKAMOTO, Keigo MAEHARA, Yube IIDA, Rinzo SOEJIMA, Toshiharu MATSUSHIMA, Yoshihito NIKI, Hiroshi KAWANE, Masayoshi KAWANISHI, Chikara NAKAHAMA, Masatoshi WATANABE, Jiro HINO, Michio YAMAKIDO, Yuzo ODA, Osamu KURIMURA, Hideo SASAKI, Hirofumi FUKUHARA, Masakazu TAMURA, Toshihiro GOTO, Eiro TSUBURA, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Kohei HARA, Kinichi IZUMIKAWA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Munetaka KOMORI, Naomi ITO, Masao SAI, Hiromaru IWASAKI, Koichi WATANABE, Akira IKEBE, Kozo YAMADA, Keizo MATSUMOTO, Yoshio UZUKA, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Shukuro ARAKI, Yasutsugu FUKUDA, Katsumasa TOKUNAGA, Haruhiko TOKUOMI, Takashi ITOGA, Masaru NASU, Jun GOTO, Yoichiro GOTO, Takayoshi TASHIRO, Kazumine KOBARI, Yuei IRABU, Yutoku KINJO, Masao NAKATOMI, and Tsuneo TANAKA

Subjects
medicine.medical_specialty, Clinical Trials as Topic, business.industry, General Medicine, Bacterial Infections, Pneumonia, Gastroenterology, Leucomycins, Midecamycin, Double blind, medicine.anatomical_structure, Double-Blind Method, Internal medicine, Pneumonia, Mycoplasma, Medicine, Humans, Miocamycin, business, medicine.drug, Respiratory tract
Published
1985

19. Activation of alveolar macrophages exposed to lavage-procured immunoglobulin G obtained from normal rabbit lungs

Author

Masayuki Ando, Moritaka Suga, Kiyoshi Shima, Mineharu Sugimoto, and Haruhiko Tokuomi

Subjects
Pathology, medicine.medical_specialty, Size-exclusion chromatography, Immunology, Biology, Microbiology, Immunoglobulin G, Sepharose, medicine, Animals, Ascitic Fluid, Incubation, Lung, Pyrogens, Macrophages, Lymphokine, Temperature, Hydrogen-Ion Concentration, Molecular biology, Pulmonary Alveoli, Infectious Diseases, medicine.anatomical_structure, Nitro, biology.protein, Parasitology, Female, Rabbits, Intracellular
Abstract

Pulmonary washings from rabbits were freed of cells and added to the monolayers of homologous alveolar macrophages (AM). At 1 h after incubation with the pulmonary washings, many more cells adhered to glass, spread out, and showed enhanced Nitro Blue Tetrazolium reduction. The maximal effect of the pulmonary washings on AM activation was obtained 12 h after incubation. The AM activated by the pulmonary washings showed a higher capacity to inhibit the growth of intracellular BCG, and that capacity was correlated with the intensity of Nitro Blue Tetrazolium reduction by the AM. Gel filtration of the pulmonary washings through Sepharose 4B yielded five fractions. The factor that activated the AM functions was in fraction 4. When the immunoglobulin G in the fraction was removed by an immunoadsorbent column, AM activity was abolished. The effect of the immunoglobulin G was dose dependent, and minimal responses to 10 6 cells per ml were obtained at a protein concentration of 20 μg/ml. Lymphokines had no effect on AM activation with respect to the morphological alterations and Nitro Blue Tetrazolium reduction during the 24-h observation time. In summary, AM from normal rabbits were soon activated markedly by lavage-procured immunoglobulin G, but not by lymphokines.

Published
1978

20. Electrophysiological characteristics of ischemic cardiac cells in hypoxic and hyperkalemic conditions

Author

Katsuhide Nishi, Yutaka Horio, Ken Okumura, and Haruhiko Tokuomi

Subjects
medicine.medical_specialty, Hyperkalemia, Physiology, Purkinje fibers, Myocardial Infarction, Stimulation, Coronary Disease, In Vitro Techniques, Purkinje Fibers, Dogs, Internal medicine, medicine, Animals, Endocardium, Membrane potential, business.industry, Arrhythmias, Cardiac, Heart, Hypoxia (medical), Oxygen, Electrophysiology, medicine.anatomical_structure, Coronary occlusion, Cardiology, Potassium, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract

The difference in the electrophysiological properties between the subepicardial cells and the subendocardial cells (Purkinje fibers and ordinary myocardial cells) was examined in dogs using a microelectrode technique. The preparations were obtained one hour after coronary occlusion. Immediately after exposure to a hypoxic solution, spontaneous activities could be recorded in neither the subepicardial nor the subendocardial cells. The electrical activities induced by electrical stimulation disappeared 5-10 min after exposure to the hypoxic solution in the subepicardial cells, while they remained in the subendocardial cells. Vmax, action potential amplitude, action potential duration and resting membrane potential of the subendocardial cells were all reduced significantly in the hypoxic solution containing 7 mK K+ in contrast to those in the hypoxic solution containing 4 mM K+ (p less than 0.001). In the hypoxic solution containing 15 mM K+, all cardiac cells depolarized partially and became electrically quiescent in both normal and ischemic cardiac cells. These findings support the idea that during regional hypoxia and hyperkalemia resulting from acute coronary occlusion, heterogeneous changes in electrical activities occur between the subepicardium and the subendocardium in the ischemic regions.

Published
1982

21. [Comparative clinical study of ofloxacin and cefaclor in bacterial bronchitis]

Author

Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Yomei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Kazuo TAKEBE, Tomio ONUMA, Shuichiro YOSHIDA, Yoshihiro KUMAZAKA, Shigeru OCHIAI, Mitsuo NAKAMURA, Tatsuro IRIE, Masashi YONEDA, Katsuhiro OKAMOTO, Shuichi TAKAHASHI, Masao TAMURA, Takashi ITO, Izumi HAYASHI, Tatsuya ABE, Teruo AOYAGI, Yuichi KOIZUMI, Masataka KATSU, Masanori ADACHI, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Isao NITTA, Kyoko WATANABE, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Takao TAKIZAWA, Jun TAMAOKI, Atsushi SAITO, Kohya SHIBA, Takehisa YAMAJI, Masanobu KAJI, Tadashi MIYAHARA, Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Fukuo IIJIMA, Kazuaki HANAOKA, Yoshiji YAMANE, Keimei MASHIMO, Hiroichi TANIMOTO, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Ryuo NAKATANI, Koichiro NAKATA, Hideo IKEMOTO, Kazuyoshi WATANABE, Tsuneo HAMAMOTO, Yuzo FUNATSU, Fuyuhiko HIGASHI, Junzaburo KABE, Hiroyoshi ISHIBASHI, Yasuyuki SANO, Masako KATO, Takeshi KAWAI, Takashi KAMO, Hiroshi UCHIDA, Hiroyuki KOBAYASHI, Kenji TAKAMURA, Kota KONO, Shohei WATANABE, Ruey-Mei CHEN, Noriko MURAKI, Keiichi NAGAO, Harushige KANNO, Hirotaka TAKIZAWA, Norio KIKUCHI, Takeshi MITSUI, Akira ITO, Kunihiko SHINDO, Shigeki ODAGIRI, Hirotada IKEDA, Kaneo SUZUKI, Kou MUROHASHI, Tamotsu KANEKO, Kazufuto FUKAYA, Fumio MATSUMOTO, Kaoru OYAMA, Katsutaka TORIKAI, Shinichi INADA, Yoichi ABE, Kunihiro ISHITANI, Nobuo MAEKAWA, Michiyasu NAKANISHI, Takekuni IWATA, Kazukiyo OIDA, Yoshio TAGUCHI, Kohei AOKI, Fumio MIKI, Kenji TAKAMATSU, Rinzo SOEJIMA, Yoshito NIKI, Masayasu KAWANISHI, Masatoshi WATANABE, Jiro HINO, Osamu KURIMURA, Yoshihiko ARATANI, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Takashi ITOGA, Masaru NASU, Jun GOTO, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Yoshiaki FUKUDA, Masamoto NAKANO, Akira IKEBE, Makoto ISHIZAKI, Tsunetoshi KOTEDA, Mikio OKA, Keizo MATSUMOTO, Harumi SHISHIDO, Kenji TSUCHIHASHI, Naoto RIKITOMI, Hisao KIMURA, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Yasutsugu FUKUDA, Katsumasa TOKUNAGA, and Haruhiko TOKUOMI

Subjects
Adult, Male, medicine.medical_specialty, Ofloxacin, Clinical study, Double blind study, Anti-Infective Agents, Double-Blind Method, Internal medicine, Oxazines, Medicine, Humans, Cefaclor, Bronchitis, Aged, Cephalexin, Clinical Trials as Topic, business.industry, General Medicine, Bacterial Infections, Middle Aged, medicine.disease, Clinical trial, Female, Bacterial bronchitis, business, medicine.drug
Published
1984

22. [A double-blind comparative study of aspoxicillin and piperacillin in the treatment of respiratory tract infections]

Author

Akira SAITO, Kiyofumi ISHIKAWA, Ichiro NAKAYAMA, Masumi TOMIZAWA, Morikuni ABE, Hidetoshi SHIBAKI, Takehisa CHIMOTO, Masahiro TANAKA, Choei ITO, Keisuke TAKEUCHI, Aiji KOJIMA, Kazuo SHIMOYAMA, Yoshinobu TAKASHIRO, Shinji OHNISHI, Masahide SHINOHARA, Akira UJIIE, Osamu YAJIMA, Fumio NAGAHAMA, Hisaji NISHIHARA, Yuichi SASAKI, Takehito NAKABAYASHI, Tetsuji KOROKU, Rensuke KURODA, Jutaro SHIMOMURA, Shin-ichi OSHIMA, Sokichi ONODERA, Nobuhiro SASAKI, Akira SUZUKI, Tohru NATSUIZAKA, Yohmei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Tsuyoshi KIKUIRI, Tadashi MURAKAMI, Kazufumi TSUCHIHASHI, Kazuo TAKEBE, Katsuhiro OKAMOTO, Shuichiro TOSHIDA, Tadanao OHMI, Shuichi TAKAHASHI, Katsutoshi KARIYA, Tomio ONUMA, Shigeru OCHIAI, Yoshihiro KUMASAKA, Shigetoshi YANAGIYA, Osamu UEHARA, Yasukimi WATABIKI, Naoyoshi MASAKI, Toyoichi TAMURA, Naoki TAMAZAWA, Hajime INOOKA, Masao TAMURA, Takashi ITOH, Ken-ichi TAKEUCHI, Ryoji OGATA, Jun KOMURO, Hiroaki ITOH, Tamotsu TAKISHIMA, Yasuo TANNO, Kiyoshi KONNO, Kotaro OHIZUMI, Akira WATANABE, Makoto KASHIWAGI, Hideo TOGASHI, Hidetaka SATO, Masato HAYASHI, Tsugushi ITOH, Izumi HAYASHI, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Masataka KATSU, Masanori ADACHI, Keimei MASHIMO, Tetsuro UKAI, Chizuru ITOH, Atsushi SAITO, Tadashi MIYAHARA, Hiroichi TANIMOTO, Akio TACHIBANA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Hideo IKEMOTO, Kazuyoshi WATANABE, Keiichi NAKAGAWA, Masaru KOYAMA, Kohjin KIN, Masami UEDA, Fukuo IIJIMA, Ryuji AKIYOSHI, Yuzo FUNATSU, Fuyuhiko HIGASHI, Hiroyuki KOBAYASHI, Hiroshi OSHITANI, Ippei FUJIMORI, Yoshio KOBAYASHI, Yasushi NAKAMURA, Kazufuto FUKAYA, Kenzo TAKAGI, Ikuo YAMAKAWA, Michihiro HARA, Tatsuo SATAKE, Toshihiko TAKEUCHI, Masahito KATO, Saburo KITAURA, Hidekazu HANAKI, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Akihiko KISHIMOTO, Youichi ABE, Katsutaka TORIGAI, Kaoru OHYAMA, Kuninori SUZUKI, Nobuo OHYA, Mitsuru HAYASE, Nobuo MAEKAWA, Michiyasu NAKANISHI, Kohei AOKI, Tsuneo MATSUBARA, Nobuaki IKEDA, Takekuni IWATA, Nobuo INABA, Hiroyuki TSUJINO, Yuruko OKAMOTO, Keigo MAEHARA, Muneto YOSHIOKA, Yube IIDA, Hiroshi OKUBO, Yoshihiro UEDA, Fumio MIKI, Kenji TAKAMATSU, Osamu MIYAMOTO, Eiro TSUBURA, Toshihiro GOTO, Masakazu TAMURA, Rinzo SOEJIMA, Yoshito NIKI, Masatoshi WATANABE, Michio YAMAKIDO, Kanoko HAYASHI, Yoshiro SAWAE, Tomohiro KUSABA, Seizaburo KASHIWAGI, Akira UEDA, Kaoru OKADA, Michio ONO, Masahide TAKII, Takatoshi OTONARI, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Koichi WATANABE, Masao NAGASAWA, Keizo MATSUMOTO, Harumi SHISHIDO, Atsushi TAKAHASHI, Masakazu TAKASUGI, Shigeru TAMAKI, Hisao KIMURA, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Katsumasa TOKUNAGA, Yasutsugu FUKUDA, and Haruhiko TOKUOMI

Subjects
Piperacillin, medicine.medical_specialty, Clinical Trials as Topic, Respiratory tract infections, business.industry, Amoxicillin, Lung abscess, General Medicine, Pneumonia, medicine.disease, Double blind, Aspoxicillin, Chronic disease, Double-Blind Method, Internal medicine, Chronic Disease, medicine, Humans, Lung Abscess, business, Respiratory Tract Infections, medicine.drug
Published
1985

23. The Histochemical Studies of Skeletal Muscle in the Investigation of Neuromuscular Diseases

Author

Masahiro Yamasita, Mituya Takaba, Gen Kimura, Haruhiko Tokuomi, and Komei Okada

Subjects
chemistry.chemical_classification, Pathology, medicine.medical_specialty, Succinic dehydrogenase, medicine.diagnostic_test, Skeletal muscle, Dehydrogenase, General Medicine, Biology, Stain, Glycogen phosphorylase, medicine.anatomical_structure, Enzyme, chemistry, Biopsy, Oxidative enzyme, medicine
Abstract

Skeletal muscle tissue was obtained by biopsy from 54 patients suspected of having various neuromuscular disease. The biopsy specimen was rapidly frozen and from it 18 to 20μ, thick serial sections were cut in a cryostat. The activities of phosphorylase (PhR, Takeuchi & Kuriaki stain, 1956) and mitochondrial oxidative enzymes such as reduced diphosphopyridine-nucleotide dehydrogenase (DPNH, Modified method of Novikoff et al. stain, 1961), DPN-linked lactic dehydrogenase (LDH, Modified method of Pearse et al. stain, 1958) and succinic dehydrogenase (SDH, Modified method of Nachlas et al. stain, 1957) were studied by histochemical techniqes in the biopsy specimen. The relationship of these enzymatic activity to fiber diameter was also studied.

Published
1965
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