Search

Your search keyword '"Hartung S"' showing total 2 results
Start Over Author "Hartung S"
2 results on '"Hartung S"'

1. Energy balance analysis of the feed zone of grooved barrel single screw extruders.

Author

Düngen, M., Hartung, S., and Koch, M.

Subjects
*EXTRUSION process, *BULK solids, *ENTHALPY, *CONVEYING machinery, *HEAT capacity
Abstract

The energy balance in the feed zone of grooved barrel single screw extruders is important for design and operation of such extruders. Experimental investigations with different bulk materials were undertaken to obtain further insight into the energy balance of the feed zone. The energy balance considers the enthalpy change resulting from temperature and density increase as a result of screw drive power and heat flow in the barrel. Experimental results show a decreasing solid bed temperature for decreasing residence times. In addition, with a reduced gap in the throttle with constant throughput, the pressure increases resulting into various deformation mechanisms of solid particles. The energy required for the deformation of solid particles into a solid bed elevates the specific screw drive power and heat generation. It is shown that the compression behavior of bulk materials is temperature-dependent and influences the energy balance in the feed zone. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

2. Invasive aspergillosis-on-chip: A quantitative treatment study of human Aspergillus fumigatus infection.

Author

Hoang, T.N.M., Cseresnyés, Z., Hartung, S., Blickensdorf, M., Saffer, C., Rennert, K., Mosig, A.S., von Lilienfeld-Toal, M., and Figge, M.T.

Subjects
*ASPERGILLUS fumigatus, *PULMONARY aspergillosis, *FUNGAL morphology, *CASPOFUNGIN, *ASPERGILLOSIS, *HUMAN experimentation, *FUNGAL growth
Abstract

Invasive pulmonary aspergillosis is associated with a high mortality rate and poses a direct threat to immunocompromised patients. Here, we present the invasive aspergillosis-on-chip (IAC) model to investigate Aspergillus fumigatus infection in vitro. The model allows the study of the lateral growth and the invasive behaviour of fungal hyphae from the epithelium into the endothelial cell layer in an alveolus-on-chip model. We established an algorithm-based analysis pipeline for three-dimensional confocal microscopy images to visualize and quantify fungal morphology, including hyphal growth and branching. Human macrophages in the IAC model partially inhibited the growth of the fungus, contributed to the release of proinflammatory cytokines (IL-1, IL-6, TNF) and chemokines (IL-8 and MCP-1) associated with an increased number of invasive hyphae. Similar to in vivo , the application of the fungistatic drug caspofungin limited the fungal growth and resulted in morphological changes of the hyphal tree previously described in other studies. The IAC infection model allows the identification and characterization of cellular infection targets and in vitro testing of antifungal drugs in clinically relevant concentrations. It thus represents a promising tool to broaden the understanding of pathogenicity and pathophysiology of invasive aspergillosis. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results