12 results on '"Hartsell J"'
Search Results
2. A STUDY OF THE EFFECTS OF ENGINE PARAMETERS ON TWO-PHASE FLOW PERFORMANCE LOSSES USING N2O4/ALUMIZINE PROPELLANTS.
- Author
-
AEROJET-GENERAL CORP SACRAMENTO CALIF, Ditore,M. J., Hartsell,J. O., AEROJET-GENERAL CORP SACRAMENTO CALIF, Ditore,M. J., and Hartsell,J. O.
- Abstract
Studies were conducted to quantitatively evaluate the effects of liquid-engine design and operating parameters on two-phase-flow performance losses using an N2O4/Alumizine-gel propellant combination. The theoretical and experimental efforts, conducted concurrently, consist of performance evaluations covering a range of variables sufficiently wide to provide an adequate basis for predicting specific impulse for large-scale engines. The theoretical analysis was made of two-phase-flow performance losses resulting from the presence of aluminum oxide in the nozzle exhaust. Particle samples, collected during each 2K engine test, are being analyzed to determine the representative particle size and distribution data for the analysis. A one-dimensional gas-particle flow analysis is being used to determine the performance losses. Preliminary computations indicate that the use of the mass median for particle-size classification yields performance losses comparable to those derived when the particle distribution is used in the analysis. Forty-two sea-level and thirteen simulated-altitude 2K engine tests have successfully been conducted. Of the altitude tests, all but two are considered to be valid performance runs capable of providing information concerning the effects of area ratio on two-phase-flow performance losses.
- Published
- 1966
3. EXAMINATION OF SECURITY EVENTS AS DBES FOR MGDS IMPORTANT TO SAFETY SSCS
- Author
-
Hartsell, J
- Published
- 1998
- Full Text
- View/download PDF
4. Practical considerations from construction of the FFTF pipe support system
- Author
-
Hartsell, J
- Published
- 1979
5. Stable Isotope Tracing Analysis in Cancer Research: Advancements and Challenges in Identifying Dysregulated Cancer Metabolism and Treatment Strategies.
- Author
-
Hilovsky D, Hartsell J, Young JD, and Liu X
- Abstract
Metabolic reprogramming is a hallmark of cancer, driving the development of therapies targeting cancer metabolism. Stable isotope tracing has emerged as a widely adopted tool for monitoring cancer metabolism both in vitro and in vivo. Advances in instrumentation and the development of new tracers, metabolite databases, and data analysis tools have expanded the scope of cancer metabolism studies across these scales. In this review, we explore the latest advancements in metabolic analysis, spanning from experimental design in stable isotope-labeling metabolomics to sophisticated data analysis techniques. We highlight successful applications in cancer research, particularly focusing on ongoing clinical trials utilizing stable isotope tracing to characterize disease progression, treatment responses, and potential mechanisms of resistance to anticancer therapies. Furthermore, we outline key challenges and discuss potential strategies to address them, aiming to enhance our understanding of the biochemical basis of cancer metabolism.
- Published
- 2024
- Full Text
- View/download PDF
6. An economic evaluation of the expansion of electronic case reporting in an academic healthcare setting.
- Author
-
Hartsell J, Wilson FA, Shoaf K, Dunn A, Samore MH, and Staes CJ
- Abstract
Objectives: Determine the economic cost or benefit of expanding electronic case reporting (eCR) for 29 reportable conditions beyond the initial eCR implementation for COVID-19 at an academic health center., Materials and Methods: The return on investment (ROI) framework was used to quantify the economic impact of the expansion of eCR from the perspective of an academic health system over a 5-year time horizon. Sensitivity analyses were performed to assess key factors such as personnel cost, inflation, and number of expanded conditions., Results: The total implementation costs for the implementation year were estimated to be $5031.46. The 5-year ROI for the expansion of eCR for the 29 conditions is expected to be 142% (net present value of savings: $7166). Based on the annual ROI, estimates suggest that the savings from the expansion of eCR will cover implementation costs in approximately 4.8 years. All sensitivity analyses yielded a strong ROI for the expansion of eCR., Discussion and Conclusion: Our findings suggest a strong ROI for the expansion of eCR at UHealth, with the most significant cost savings observed implementing eCR for all reportable conditions. An early effort to ensure data quality is recommended to expedite the transition from parallel reporting to production to improve the ROI for healthcare organizations. This study demonstrates a positive ROI for the expansion of eCR to additional reportable conditions beyond COVID-19 in an academic health setting, such as UHealth. While this evaluation focuses on the 5-year time horizon, the potential benefit could extend further., Competing Interests: JH serves as a consultant for the Association of Public Health Laboratories’ Electronic Case Reporting Team., (© The Author(s) 2024. Published by Oxford University Press on behalf of the American Medical Informatics Association.)
- Published
- 2024
- Full Text
- View/download PDF
7. Strengths, weaknesses, opportunities, and threats for the nation's public health information systems infrastructure: synthesis of discussions from the 2022 ACMI Symposium.
- Author
-
Acharya JC, Staes C, Allen KS, Hartsell J, Cullen TA, Lenert L, Rucker DW, Lehmann HP, and Dixon BE
- Abstract
Objective: The annual American College of Medical Informatics (ACMI) symposium focused discussion on the national public health information systems (PHIS) infrastructure to support public health goals. The objective of this article is to present the strengths, weaknesses, threats, and opportunities (SWOT) identified by public health and informatics leaders in attendance., Materials and Methods: The Symposium provided a venue for experts in biomedical informatics and public health to brainstorm, identify, and discuss top PHIS challenges. Two conceptual frameworks, SWOT and the Informatics Stack, guided discussion and were used to organize factors and themes identified through a qualitative approach., Results: A total of 57 unique factors related to the current PHIS were identified, including 9 strengths, 22 weaknesses, 14 opportunities, and 14 threats, which were consolidated into 22 themes according to the Stack. Most themes (68%) clustered at the top of the Stack. Three overarching opportunities were especially prominent: (1) addressing the needs for sustainable funding, (2) leveraging existing infrastructure and processes for information exchange and system development that meets public health goals, and (3) preparing the public health workforce to benefit from available resources., Discussion: The PHIS is unarguably overdue for a strategically designed, technology-enabled, information infrastructure for delivering day-to-day essential public health services and to respond effectively to public health emergencies., Conclusion: Most of the themes identified concerned context, people, and processes rather than technical elements. We recommend that public health leadership consider the possible actions and leverage informatics expertise as we collectively prepare for the future., (© The Author(s) 2023. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2023
- Full Text
- View/download PDF
8. Enhancing the nation's public health information infrastructure: a report from the ACMI symposium.
- Author
-
Dixon BE, Staes C, Acharya J, Allen KS, Hartsell J, Cullen T, Lenert L, Rucker DW, and Lehmann H
- Subjects
- United States, Humans, Public Health, Pandemics, COVID-19, Medical Informatics
- Abstract
The COVID-19 pandemic exposed multiple weaknesses in the nation's public health system. Therefore, the American College of Medical Informatics selected "Rebuilding the Nation's Public Health Informatics Infrastructure" as the theme for its annual symposium. Experts in biomedical informatics and public health discussed strategies to strengthen the US public health information infrastructure through policy, education, research, and development. This article summarizes policy recommendations for the biomedical informatics community postpandemic. First, the nation must perceive the health data infrastructure to be a matter of national security. The nation must further invest significantly more in its health data infrastructure. Investments should include the education and training of the public health workforce as informaticians in this domain are currently limited. Finally, investments should strengthen and expand health data utilities that increasingly play a critical role in exchanging information across public health and healthcare organizations., (© The Author(s) 2023. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2023
- Full Text
- View/download PDF
9. The Effects of Social Distancing Policies on Non-SARS-CoV-2 Respiratory Pathogens.
- Author
-
Nawrocki J, Olin K, Holdrege MC, Hartsell J, Meyers L, Cox C, Powell M, Cook CV, Jones J, Robbins T, Hemmert A, and Ginocchio CC
- Abstract
Background: The initial focus of the US public health response to coronavirus disease 2019 (COVID-19) was the implementation of numerous social distancing policies. While COVID-19 was the impetus for imposing these policies, it is not the only respiratory disease affected by their implementation. This study aimed to assess the impact of social distancing policies on non-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) respiratory pathogens typically circulating across multiple US states., Methods: Linear mixed-effect models were implemented to explore the effects of 5 social distancing policies on non-SARS-CoV-2 respiratory pathogens across 9 states from January 1 through May 1, 2020. The observed 2020 pathogen detection rates were compared week by week with historical rates to determine when the detection rates were different., Results: Model results indicate that several social distancing policies were associated with a reduction in total detection rate, by nearly 15%. Policies were associated with decreases in pathogen circulation of human rhinovirus/enterovirus and human metapneumovirus, as well as influenza A, which typically decrease after winter. Parainfluenza viruses failed to circulate at historical levels during the spring. The total detection rate in April 2020 was 35% less than the historical average. Many of the pathogens driving this difference fell below the historical detection rate ranges within 2 weeks of initial policy implementation., Conclusions: This analysis investigated the effect of multiple social distancing policies implemented to reduce transmission of SARS-CoV-2 on non-SARS-CoV-2 respiratory pathogens. These findings suggest that social distancing policies may be used as an impactful public health tool to reduce communicable respiratory illness., (© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
- Published
- 2021
- Full Text
- View/download PDF
10. Increased Gonorrhea Cases - Utah, 2009-2014.
- Author
-
Watson J, Carlile J, Dunn A, Evans M, Fratto E, Hartsell J, Meinor L, Mietchen M, and Nakashima A
- Subjects
- Adolescent, Adult, Ethnicity statistics & numerical data, Female, Gonorrhea ethnology, Homosexuality, Male ethnology, Homosexuality, Male statistics & numerical data, Humans, Male, Racial Groups statistics & numerical data, Risk Factors, Utah epidemiology, Young Adult, Gonorrhea epidemiology
- Abstract
Gonorrhea (caused by infection with Neisseria gonorrhoeae) is the second most commonly reported notifiable disease in the United States (1). Left untreated, gonorrhea is associated with serious long-term adverse health effects, including pelvic inflammatory disease, ectopic pregnancy, and infertility. Infection also facilitates transmission of human immunodeficiency virus (2,3). Effective gonorrhea control relies upon early detection and effective antimicrobial treatment. To assess gonorrhea rate trends in Utah, the Utah Department of Health (UDOH) analyzed Utah National Electronic Disease Surveillance System (UT-NEDSS) data for the state during 2009-2014. After declining during 2009-2011, the statewide gonorrhea rate increased fivefold to 49 cases per 100,000 population in 2014. During 2009-2014, the proportion of cases among women increased from 21% to 39% (decreasing among males from 79% to 61%). Among male patients, the proportion who identified as men who have sex with men (MSM) decreased from 67% to 42%. These demographic changes suggest that increased heterosexual transmission of gonorrhea in Utah might be occurring. Health departments need to work with providers to ensure populations at high risk are being screened and properly treated for gonorrhea. Clinicians need to be aware of increases in the risk for infection among women and non-MSM males when making screening and testing decisions and educate their patients regarding gonorrhea transmission and prevention practices.
- Published
- 2016
- Full Text
- View/download PDF
11. Characterization of a CLE processing activity.
- Author
-
Ni J, Guo Y, Jin H, Hartsell J, and Clark SE
- Subjects
- Amino Acid Sequence, Arabidopsis Proteins genetics, Arginine genetics, Arginine metabolism, Binding Sites, Brassica chemistry, Carboxypeptidases metabolism, Cells, Cultured, Glutathione Transferase genetics, Glutathione Transferase metabolism, Hydrogen-Ion Concentration, Immunoblotting, Leucine analogs & derivatives, Leucine metabolism, Mass Spectrometry, Molecular Sequence Data, Plant Leaves metabolism, Plant Proteins metabolism, Plant Roots metabolism, Protein Precursors genetics, Recombinant Fusion Proteins genetics, Recombinant Fusion Proteins metabolism, Nicotiana cytology, Nicotiana metabolism, Arabidopsis Proteins metabolism, Protease Inhibitors metabolism, Protein Precursors metabolism, Serine Proteases metabolism
- Abstract
Proteins containing a conserved motif known as the CLE domain are found widely distributed across land plants. While the functions of most CLE proteins are unknown, specific CLE proteins have been shown to control shoot meristem, root and vascular development. This has been best studied for CLV3 which is required for stem cell differentiation at shoot and flower meristems. In vivo evidence indicates that the CLE domain is the functional region for CLV3, and that it is proteolytically processed from the CLV3 precursor protein. But the mechanism and activity responsible for this processing is poorly understood. Here we extend analysis of an in vitro CLE processing activity and show that in vitro cleavage occurs at Arg70, exactly matching in vivo maturation. We provide evidence that related processing activities are present in multiple tissues and species. We show that efficient protease recognition can occur with as little as four residues upstream of the CLE domain, and that the conserved arginine at position +1 and conserved acidic residues at positions -2 and/or -3 are required for efficient cleavage. Finally, we provide evidence that the N-terminal processing enzyme is a secreted serine protease while C-terminal processing may occur via a progressive carboxypeptidase.
- Published
- 2011
- Full Text
- View/download PDF
12. Mother may I ... live? Parental refusal of life-sustaining medical treatment for children based on religious objections.
- Author
-
Hartsell JL
- Subjects
- Child, Child Welfare legislation & jurisprudence, Christian Science, Criminal Law, Humans, Parent-Child Relations legislation & jurisprudence, Religion and Medicine, Tennessee, United States, Child Advocacy legislation & jurisprudence, Faith Healing legislation & jurisprudence, Parents, Treatment Refusal legislation & jurisprudence
- Published
- 1999
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.