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19 results on '"Hartmann, Diego O."'

2. NmrB (AN9181) expression is activated under oxidative stress conditions acting as a metabolic repressor of Aspergillus nidulans.

Author

Jorge, João M. P., Martins, Celso, Domingos, Patrícia, Martins, Tiago M., Hartmann, Diego O., Goldman, Gustavo H., and Silva Pereira, Cristina

Subjects
ASPERGILLUS nidulans, PHENOTYPIC plasticity, SPECIES diversity, ORGANIC compounds, DELETION mutation, OXIDATIVE stress
Abstract

Aspergilli comprise a diversity of species that have been extensively studied due to their catabolic diversity, biotechnological and ecological value, and pathogenicity. An impressive level of structural and functional conservation has been shown for aspergilli, regardless of many (yet) cryptic genomic elements. We have hypothesized the existence of conserved genes responsive to stress in aspergilli. To test the hypothesis of such conserved stress regulators in aspergilli, a straightforward computational strategy integrating well-established bioinformatic tools was used as the starting point. Specifically, five transcriptome-based datasets on exposure to organic compounds were used, covering three distinct Aspergillus species. Among the identified up-regulated genes, only one gene showed the same response in all conditions, AN9181. This gene encodes a protein containing a phenylcoumaran benzylic ether reductase-like domain and a Nitrogen metabolite repressor regulator domain (NmrA). Deletion of this gene caused significant phenotypic alterations compared to that of the parental strain across diverse conditions. Specifically, the deletion of AN9181 raised the mutant's metabolic activity in different nitrogen sources. The acquired data supports that AN9181 acts by repressing (slowing down) A. nidulans growth when exposed to aromatic compounds in a concentration dependent manner. The same phenotype was observed for amphotericin B. Finally, AN9181 underwent differential upregulation under oxidative stress conditions. Collectively, the data suggest that AN9181, herein assigned as NmrB (Nitrogen Metabolite Repression Regulator B), builds up the genetic machinery of perception of oxidative stress by negatively regulating growth under such conditions. [ABSTRACT FROM AUTHOR]

Published
2024
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7. List of Contributors

Author

Benjamin, Kenneth, primary, Berton-Carabin, Claire C., additional, Chaijan, Manat, additional, Cheong, Ling-Zhi, additional, Cooney, Michael J., additional, Coutinho, João A.P., additional, Davis, James H., additional, Falkeborg, Mia, additional, Fernández, Vicente Gotor, additional, Guo, Zheng, additional, Hartmann, Diego O., additional, Kahveci, Derya, additional, Li, Jingbo, additional, Mirjafari, Arsalan, additional, Mohd Yusoff, Mohd Firdaus, additional, O'Brien, Richard A., additional, Panpipat, Worawan, additional, Paul, Caroline Emilie, additional, Pereira, Cristina Silva, additional, Pérez, Bianca, additional, Prabhavathi Devi, Bethala Lakshmi Anu, additional, Ventura, Sónia P.M., additional, Vijai Kumar Reddy, Tangadanchu, additional, Wei, Wei, additional, Xu, Xuebing, additional, Zhao, Hua, additional, and Zhong, Nanjing, additional

Published
2016
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19. Viscosimetric study of aqueous solutions of imidazolium based ionic liquids: Influence of alkyl chain length

Author

Tomaš, Renato, Tot, Aleksandar, Bešter-Rogač, Marija, Pereira, Cristina Silva, and Hartmann, Diego O.

Subjects
viscosity, density, ionic liquids, water, 1, 3-dimethylimidazolium chloride, 1-butyl-3-methylimidazolium chloride, viscosity B-coefficient
Abstract

The viscosities of aqueous solutions of 1, 3-dimethylimidazolium chloride and 1-butyl-3-methylimidazolium chloride were measured in the temperature range (5 – 40C) in steps of 5C covering the concentration range of investigated ionic liquids, ILs (0.005 – 0.1 mol dm–3). The relative viscosity data have been analyzed using Jones-Dole equation and the derived parameters as viscosity B-coefficient and A-coefficient have been interpreted in terms of solute-solvent and solute-solute interaction, respectively. The viscosity A-coefficients were also calculated from Falkenhagen and Vernon theory by help of the literature limiting ionic conductivity data, and compared with the experimental values. The structure making or structure breaking capacity of this ILs investigated here will be discussed.

Published
2016

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