541 results on '"Hartman, George D."'
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2. Antitumor Efficacy of a Farnesyltransferase Inhibitor in Transgenic Mice
3. Discovery of selective glucocorticoid receptor modulator MK-5932
4. Discovery of the Selective Androgen Receptor Modulator MK-0773 Using a Rational Development Strategy Based on Differential Transcriptional Requirements for Androgenic Anabolism Versus Reproductive Physiology
5. Stereospecific reduction of a potent kinesin spindle protein (KSP) inhibitor in human tissues
6. Oxadiazepinone HBV capsid assembly modulators
7. Identification of Anabolic Selective Androgen Receptor Modulators with Reduced Activities in Reproductive Tissues and Sebaceous Glands
8. Identification of a new class of HBV capsid assembly modulator
9. Protein Farnesyltransferase Inhibitors Block the Growth of ras-Dependent Tumors in Nude Mice
10. SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators
11. Anti-Resorptive and Anabolic Bone Agents
12. Farnesyltransferase inhibitors and anti-Ras therapy
13. Pharmacokinetics and Pharmacodynamics of L-703,014, a Potent Fibrinogen Receptor Antagonist, After Intravenous and Oral Administration in the Dog
14. Inhibition of a Mitotic Motor Protein: Where, How, and Conformational Consequences
15. P450s under Restriction (PURE) Screen Using HepaRG and Primary Human Hepatocytes for Discovery of Novel HBV Antivirals
16. Large-scale synthesis of L-367, 073, a potent cyclic heptapeptide platelet fibrinogen receptor antagonist
17. Anions Modulate the Potency of Geranylgeranyl-Protein Transferase I Inhibitors
18. Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics
19. Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus
20. MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate
21. Fibrinogen Receptor Antagonist-Induced Thrombocytopenia in Chimpanzee and Rhesus Monkey Associated With Preexisting Drug-Dependent Antibodies to Platelet Glycoprotein IIb/IIIa
22. Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase
23. Nonpeptide glycoprotein IIB/IIIA inhibitors. 19. A new design paradigm employing linearly minimized, centrally constrained, exosite inhibitors
24. Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase
25. Hepatitis B Virus Capsid Assembly Modulators, but Not Nucleoside Analogs, Inhibit the Production of Extracellular Pregenomic RNA and Spliced RNA Variants
26. Discovery of MK-3697: A selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia
27. Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase
28. Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M1 positive allosteric modulators
29. Benzimidazole CB2 agonists: Design, synthesis and SAR
30. Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs)
31. Pyridyl aminothiazoles as potent Chk1 inhibitors: Optimization of cellular activity
32. Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates
33. Identification of non-amidine inhibitors of acid-sensing ion channel-3 (ASIC3)
34. High concentration electrophysiology-based fragment screen: Discovery of novel acid-sensing ion channel 3 (ASIC3) inhibitors
35. Fused heterocyclic M 1 positive allosteric modulators
36. Imidazopyridine CB2 agonists: Optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy
37. Decahydroquinoline amides as highly selective CB2 agonists: Role of selectivity on in vivo efficacy in a rodent model of analgesia
38. Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series
39. Pyridyl amides as potent inhibitors of T-type calcium channels
40. Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists
41. Tricyclic imidazole antagonists of the Neuropeptide S Receptor
42. Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat
43. Conformational restriction of flexible ligands guided by the transferred NOE experiment: potent macrocyclic inhibitors of farnesyltransferase
44. Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists
45. 3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts
46. Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel
47. Heterocyclic fused pyridone carboxylic acid M 1 positive allosteric modulators
48. Hydroxy cycloalkyl fused pyridone carboxylic acid M 1 positive allosteric modulators
49. Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists
50. N-Heterocyclic derived M 1 positive allosteric modulators
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