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717 results on '"Hartl, Dominik"'

11. Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates and humans

Author

Jüttner, Josephine, Szabo, Arnold, Gross-Scherf, Brigitte, Morikawa, Rei K., Rompani, Santiago B., Hantz, Peter, Szikra, Tamas, Esposti, Federico, Cowan, Cameron S., Bharioke, Arjun, Patino-Alvarez, Claudia P., Keles, Özkan, Kusnyerik, Akos, Azoulay, Thierry, Hartl, Dominik, Krebs, Arnaud R., Schübeler, Dirk, Hajdu, Rozina I., Lukats, Akos, Nemeth, Janos, Nagy, Zoltan Z., Wu, Kun-Chao, Wu, Rong-Han, Xiang, Lue, Fang, Xiao-Long, Jin, Zi-Bing, Goldblum, David, Hasler, Pascal W., Scholl, Hendrik P. N., Krol, Jacek, and Roska, Botond

Published
2019
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12. Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis

Author

Herster, Franziska, Bittner, Zsofia, Archer, Nathan K., Dickhöfer, Sabine, Eisel, David, Eigenbrod, Tatjana, Knorpp, Thomas, Schneiderhan-Marra, Nicole, Löffler, Markus W., Kalbacher, Hubert, Vierbuchen, Tim, Heine, Holger, Miller, Lloyd S., Hartl, Dominik, Freund, Lukas, Schäkel, Knut, Heister, Martin, Ghoreschi, Kamran, and Weber, Alexander N. R.

Published
2020
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14. Supplementary Table 4 from Functional TLR5 Genetic Variants Affect Human Colorectal Cancer Survival

Author

Klimosch, Sascha N., primary, Försti, Asta, primary, Eckert, Jana, primary, Knežević, Jelena, primary, Bevier, Melanie, primary, von Schönfels, Witigo, primary, Heits, Nils, primary, Walter, Jessica, primary, Hinz, Sebastian, primary, Lascorz, Jesus, primary, Hampe, Jochen, primary, Hartl, Dominik, primary, Frick, Julia-Stefanie, primary, Hemminki, Kari, primary, Schafmayer, Clemens, primary, and Weber, Alexander N.R., primary

Published
2023
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15. Supplementary Table 2 from Functional TLR5 Genetic Variants Affect Human Colorectal Cancer Survival

Author

Klimosch, Sascha N., primary, Försti, Asta, primary, Eckert, Jana, primary, Knežević, Jelena, primary, Bevier, Melanie, primary, von Schönfels, Witigo, primary, Heits, Nils, primary, Walter, Jessica, primary, Hinz, Sebastian, primary, Lascorz, Jesus, primary, Hampe, Jochen, primary, Hartl, Dominik, primary, Frick, Julia-Stefanie, primary, Hemminki, Kari, primary, Schafmayer, Clemens, primary, and Weber, Alexander N.R., primary

Published
2023
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16. Supplementary Table 1 from Functional TLR5 Genetic Variants Affect Human Colorectal Cancer Survival

Author

Klimosch, Sascha N., primary, Försti, Asta, primary, Eckert, Jana, primary, Knežević, Jelena, primary, Bevier, Melanie, primary, von Schönfels, Witigo, primary, Heits, Nils, primary, Walter, Jessica, primary, Hinz, Sebastian, primary, Lascorz, Jesus, primary, Hampe, Jochen, primary, Hartl, Dominik, primary, Frick, Julia-Stefanie, primary, Hemminki, Kari, primary, Schafmayer, Clemens, primary, and Weber, Alexander N.R., primary

Published
2023
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17. Supplementary Methods from Functional TLR5 Genetic Variants Affect Human Colorectal Cancer Survival

Author

Klimosch, Sascha N., primary, Försti, Asta, primary, Eckert, Jana, primary, Knežević, Jelena, primary, Bevier, Melanie, primary, von Schönfels, Witigo, primary, Heits, Nils, primary, Walter, Jessica, primary, Hinz, Sebastian, primary, Lascorz, Jesus, primary, Hampe, Jochen, primary, Hartl, Dominik, primary, Frick, Julia-Stefanie, primary, Hemminki, Kari, primary, Schafmayer, Clemens, primary, and Weber, Alexander N.R., primary

Published
2023
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18. Supplementary Table 5 from Functional TLR5 Genetic Variants Affect Human Colorectal Cancer Survival

Author

Klimosch, Sascha N., primary, Försti, Asta, primary, Eckert, Jana, primary, Knežević, Jelena, primary, Bevier, Melanie, primary, von Schönfels, Witigo, primary, Heits, Nils, primary, Walter, Jessica, primary, Hinz, Sebastian, primary, Lascorz, Jesus, primary, Hampe, Jochen, primary, Hartl, Dominik, primary, Frick, Julia-Stefanie, primary, Hemminki, Kari, primary, Schafmayer, Clemens, primary, and Weber, Alexander N.R., primary

Published
2023
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19. Supplementary Figure Legend from Functional TLR5 Genetic Variants Affect Human Colorectal Cancer Survival

Author

Klimosch, Sascha N., primary, Försti, Asta, primary, Eckert, Jana, primary, Knežević, Jelena, primary, Bevier, Melanie, primary, von Schönfels, Witigo, primary, Heits, Nils, primary, Walter, Jessica, primary, Hinz, Sebastian, primary, Lascorz, Jesus, primary, Hampe, Jochen, primary, Hartl, Dominik, primary, Frick, Julia-Stefanie, primary, Hemminki, Kari, primary, Schafmayer, Clemens, primary, and Weber, Alexander N.R., primary

Published
2023
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20. Supplementary Table 6 from Functional TLR5 Genetic Variants Affect Human Colorectal Cancer Survival

Author

Klimosch, Sascha N., primary, Försti, Asta, primary, Eckert, Jana, primary, Knežević, Jelena, primary, Bevier, Melanie, primary, von Schönfels, Witigo, primary, Heits, Nils, primary, Walter, Jessica, primary, Hinz, Sebastian, primary, Lascorz, Jesus, primary, Hampe, Jochen, primary, Hartl, Dominik, primary, Frick, Julia-Stefanie, primary, Hemminki, Kari, primary, Schafmayer, Clemens, primary, and Weber, Alexander N.R., primary

Published
2023
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21. Supplementary Figure 1 from Functional TLR5 Genetic Variants Affect Human Colorectal Cancer Survival

Author

Klimosch, Sascha N., primary, Försti, Asta, primary, Eckert, Jana, primary, Knežević, Jelena, primary, Bevier, Melanie, primary, von Schönfels, Witigo, primary, Heits, Nils, primary, Walter, Jessica, primary, Hinz, Sebastian, primary, Lascorz, Jesus, primary, Hampe, Jochen, primary, Hartl, Dominik, primary, Frick, Julia-Stefanie, primary, Hemminki, Kari, primary, Schafmayer, Clemens, primary, and Weber, Alexander N.R., primary

Published
2023
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22. Supplementary Table 3 from Functional TLR5 Genetic Variants Affect Human Colorectal Cancer Survival

Author

Klimosch, Sascha N., primary, Försti, Asta, primary, Eckert, Jana, primary, Knežević, Jelena, primary, Bevier, Melanie, primary, von Schönfels, Witigo, primary, Heits, Nils, primary, Walter, Jessica, primary, Hinz, Sebastian, primary, Lascorz, Jesus, primary, Hampe, Jochen, primary, Hartl, Dominik, primary, Frick, Julia-Stefanie, primary, Hemminki, Kari, primary, Schafmayer, Clemens, primary, and Weber, Alexander N.R., primary

Published
2023
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23. Supplementary Figure 3 from Functional TLR5 Genetic Variants Affect Human Colorectal Cancer Survival

Author

Klimosch, Sascha N., primary, Försti, Asta, primary, Eckert, Jana, primary, Knežević, Jelena, primary, Bevier, Melanie, primary, von Schönfels, Witigo, primary, Heits, Nils, primary, Walter, Jessica, primary, Hinz, Sebastian, primary, Lascorz, Jesus, primary, Hampe, Jochen, primary, Hartl, Dominik, primary, Frick, Julia-Stefanie, primary, Hemminki, Kari, primary, Schafmayer, Clemens, primary, and Weber, Alexander N.R., primary

Published
2023
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24. Data from Functional TLR5 Genetic Variants Affect Human Colorectal Cancer Survival

Author

Klimosch, Sascha N., primary, Försti, Asta, primary, Eckert, Jana, primary, Knežević, Jelena, primary, Bevier, Melanie, primary, von Schönfels, Witigo, primary, Heits, Nils, primary, Walter, Jessica, primary, Hinz, Sebastian, primary, Lascorz, Jesus, primary, Hampe, Jochen, primary, Hartl, Dominik, primary, Frick, Julia-Stefanie, primary, Hemminki, Kari, primary, Schafmayer, Clemens, primary, and Weber, Alexander N.R., primary

Published
2023
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25. Supplementary Figure 4 from Functional TLR5 Genetic Variants Affect Human Colorectal Cancer Survival

Author

Klimosch, Sascha N., primary, Försti, Asta, primary, Eckert, Jana, primary, Knežević, Jelena, primary, Bevier, Melanie, primary, von Schönfels, Witigo, primary, Heits, Nils, primary, Walter, Jessica, primary, Hinz, Sebastian, primary, Lascorz, Jesus, primary, Hampe, Jochen, primary, Hartl, Dominik, primary, Frick, Julia-Stefanie, primary, Hemminki, Kari, primary, Schafmayer, Clemens, primary, and Weber, Alexander N.R., primary

Published
2023
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26. Supplementary Figure 2 from Functional TLR5 Genetic Variants Affect Human Colorectal Cancer Survival

Author

Klimosch, Sascha N., primary, Försti, Asta, primary, Eckert, Jana, primary, Knežević, Jelena, primary, Bevier, Melanie, primary, von Schönfels, Witigo, primary, Heits, Nils, primary, Walter, Jessica, primary, Hinz, Sebastian, primary, Lascorz, Jesus, primary, Hampe, Jochen, primary, Hartl, Dominik, primary, Frick, Julia-Stefanie, primary, Hemminki, Kari, primary, Schafmayer, Clemens, primary, and Weber, Alexander N.R., primary

Published
2023
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34. Abstract B66: Superiority of dual IDO1/TDO2 inhibition versus IDO1 selective inhibition in reducing immunosuppressive KYN levels in tumors co-expressing IDO1 and TDO2

Author

Lotz-Jenne, Carina, primary, Cren, Sylvaine, additional, Joesch, Christoph, additional, Ackerknecht, Sabine, additional, Brandes, Jennifer, additional, Moebs, Claire, additional, Hartl, Dominik, additional, Hartrampf, Felix, additional, Guerry, Philippe, additional, Pothier, Julien, additional, and Chavanton-Arpel, Alexia, additional

Published
2022
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36. Sarkoidose

Author

Reinhardt, Dietrich, Hartl, Dominik, Reinhardt, Dietrich, editor, Nicolai, Thomas, editor, and Zimmer, Klaus-Peter, editor

Published
2014
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39. Increased Risk of Interstitial Lung Disease in Children with a Single R288K Variant of ABCA3

Author

Wittmann, Thomas, Frixel, Sabrina, Höppner, Stefanie, Schindlbeck, Ulrike, Schams, Andrea, Kappler, Matthias, Hegermann, Jan, Wrede, Christoph, Liebisch, Gerhard, Vierzig, Anne, Zacharasiewicz, Angela, Kopp, Matthias Volkmar, Poets, Christian F, Baden, Winfried, Hartl, Dominik, van Kaam, Anton H, Lohse, Peter, Aslanidis, Charalampos, Zarbock, Ralf, and Griese, Matthias

Published
2016
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40. Competition between DNA methylation and transcription factors determines binding of NRF1

Author

Domcke, Silvia, Bardet, Anais Flore, Ginno, Paul Adrian, Hartl, Dominik, Burger, Lukas, and Schubeler, Dirk

Subjects
Gene expression -- Health aspects, Genetic research, Transcription factors -- Properties, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Eukaryotic transcription factors (TFs) are key determinants of gene activity, yet they bind only a fraction of their corresponding DNA sequence motifs in any given cell type (1). Chromatin has the potential to restrict accessibility of binding sites; however, in which context chromatin states are instructive for TF binding remains mainly unknown (1, 2). To explore the contribution of DNA methylation to constrained TF binding, we mapped DNase-I-hypersensitive sites in murine stem cells in the presence and absence of DNA methylation. Methylation-restricted sites are enriched for TF motifs containing CpGs, especially for those of NRF1. In fact, the TF NRF1 occupies several thousand additional sites in the unmethylated genome, resulting in increased transcription. Restoring de novo methyltransferase activity initiates remethylation at these sites and outcompetes NRF1 binding. This suggests that binding of DNA-methylation-sensitive TFs relies on additional determinants to induce local hypomethylation. In support of this model, removal of neighbouring motifs in cis or of a TF in trans causes local hypermethylation and subsequent loss of NRF1 binding. This competition between DNA methylation and TFs in vivo reveals a case of cooperativity between TFs that acts indirectly via DNA methylation. Methylation removal by methylation-insensitive factors enables occupancy of methylation-sensitive factors, a principle that rationalizes hypomethylation of regulatory regions., Methylation of DNA at cytosines within CpG dinucleotides has the potential to block TF binding either directly through interference with base recognition or indirectly through recruitment of methylation-specific binding proteins [...]

Published
2015

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