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3. Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer‐specific survival

Author

Morra, Anna, Schreurs, Maartje AC, Andrulis, Irene L, Anton‐Culver, Hoda, Augustinsson, Annelie, Beckmann, Matthias W, Behrens, Sabine, Bojesen, Stig E, Bolla, Manjeet K, Brauch, Hiltrud, Broeks, Annegien, Buys, Saundra S, Camp, Nicola J, Castelao, Jose E, Cessna, Melissa H, Chang‐Claude, Jenny, Chung, Wendy K, Sahlberg, Kristine K, Børresen‐Dale, Anne‐Lise, Gram, Inger Torhild, Olsen, Karina Standahl, Engebråten, Olav, Naume, Bjørn, Geisler, Jürgen, OSBREAC, Alnæs, Grethe I Grenaker, Colonna, Sarah V, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, Dennis, Joe, Devilee, Peter, Dörk, Thilo, Dunning, Alison M, Dwek, Miriam, Easton, Douglas F, Eccles, Diana M, Eriksson, Mikael, Evans, D Gareth, Fasching, Peter A, Fehm, Tanja N, Figueroa, Jonine D, Flyger, Henrik, Gabrielson, Marike, Gago‐Dominguez, Manuela, García‐Closas, Montserrat, García‐Sáenz, José A, Genkinger, Jeanine, Grassmann, Felix, Gündert, Melanie, Hahnen, Eric, Haiman, Christopher A, Hamann, Ute, Harrington, Patricia A, Hartikainen, Jaana M, Hoppe, Reiner, Hopper, John L, Houlston, Richard S, Howell, Anthony, Clarke, Christine, Marsh, Deborah, Scott, Rodney, Baxter, Robert, Yip, Desmond, Carpenter, Jane, Davis, Alison, Pathmanathan, Nirmala, Simpson, Peter, Graham, J Dinny, Sachchithananthan, Mythily, Amor, David, Andrews, Lesley, Antill, Yoland, Balleine, Rosemary, Beesley, Jonathan, Bennett, Ian, Bogwitz, Michael, Botes, Leon, Brennan, Meagan, Brown, Melissa, Buckley, Michael, Burke, Jo, Butow, Phyllis, Caldon, Liz, Campbell, Ian, Cao, Michelle, Chakrabarti, Anannya, Chauhan, Deepa, Chauhan, Manisha, Chenevix‐Trench, Georgia, Christian, Alice, Cohen, Paul, Colley, Alison, Crook, Ashley, Cui, James, Courtney, Eliza, Cummings, Margaret, and Dawson, Sarah‐Jane

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Women's Health, Breast Cancer, Clinical Research, Prevention, Cancer, Female, Humans, Breast Neoplasms, Checkpoint Kinase 2, Genetic Predisposition to Disease, Germ-Line Mutation, Heterozygote, Proportional Hazards Models, CHEK2 c.1100delC germline genetic variant, contralateral breast cancer risk, radiotherapy, survival, systemic treatment, NBCS Collaborators, ABCTB Investigators, kConFab Investigators, Biochemistry and Cell Biology, Oncology and carcinogenesis
Abstract

BackgroundBreast cancer (BC) patients with a germline CHEK2 c.1100delC variant have an increased risk of contralateral BC (CBC) and worse BC-specific survival (BCSS) compared to non-carriers.AimTo assessed the associations of CHEK2 c.1100delC, radiotherapy, and systemic treatment with CBC risk and BCSS.MethodsAnalyses were based on 82,701 women diagnosed with a first primary invasive BC including 963 CHEK2 c.1100delC carriers; median follow-up was 9.1 years. Differential associations with treatment by CHEK2 c.1100delC status were tested by including interaction terms in a multivariable Cox regression model. A multi-state model was used for further insight into the relation between CHEK2 c.1100delC status, treatment, CBC risk and death.ResultsThere was no evidence for differential associations of therapy with CBC risk by CHEK2 c.1100delC status. The strongest association with reduced CBC risk was observed for the combination of chemotherapy and endocrine therapy [HR (95% CI): 0.66 (0.55-0.78)]. No association was observed with radiotherapy. Results from the multi-state model showed shorter BCSS for CHEK2 c.1100delC carriers versus non-carriers also after accounting for CBC occurrence [HR (95% CI): 1.30 (1.09-1.56)].ConclusionSystemic therapy was associated with reduced CBC risk irrespective of CHEK2 c.1100delC status. Moreover, CHEK2 c.1100delC carriers had shorter BCSS, which appears not to be fully explained by their CBC risk.

Published
2023

4. Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry

Author

Mueller, Stefanie H, Lai, Alvina G, Valkovskaya, Maria, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Lush, Michael, Abu-Ful, Zomoruda, Ahearn, Thomas U, Andrulis, Irene L, Anton-Culver, Hoda, Antonenkova, Natalia N, Arndt, Volker, Aronson, Kristan J, Augustinsson, Annelie, Baert, Thais, Freeman, Laura E Beane, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Blomqvist, Carl, Bogdanova, Natalia V, Bojesen, Stig E, Bonanni, Bernardo, Brenner, Hermann, Brucker, Sara Y, Buys, Saundra S, Castelao, Jose E, Chan, Tsun L, Chang-Claude, Jenny, Chanock, Stephen J, Choi, Ji-Yeob, Chung, Wendy K, Colonna, Sarah V, Cornelissen, Sten, Couch, Fergus J, Czene, Kamila, Daly, Mary B, Devilee, Peter, Dörk, Thilo, Dossus, Laure, Dwek, Miriam, Eccles, Diana M, Ekici, Arif B, Eliassen, A Heather, Engel, Christoph, Evans, D Gareth, Fasching, Peter A, Fletcher, Olivia, Flyger, Henrik, Gago-Dominguez, Manuela, Gao, Yu-Tang, García-Closas, Montserrat, García-Sáenz, José A, Genkinger, Jeanine, Gentry-Maharaj, Aleksandra, Grassmann, Felix, Guénel, Pascal, Gündert, Melanie, Haeberle, Lothar, Hahnen, Eric, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Harkness, Elaine F, Harrington, Patricia A, Hartikainen, Jaana M, Hartman, Mikael, Hein, Alexander, Ho, Weang-Kee, Hooning, Maartje J, Hoppe, Reiner, Hopper, John L, Houlston, Richard S, Howell, Anthony, Hunter, David J, Huo, Dezheng, Ito, Hidemi, Iwasaki, Motoki, Jakubowska, Anna, Janni, Wolfgang, John, Esther M, Jones, Michael E, Jung, Audrey, Kaaks, Rudolf, Kang, Daehee, Khusnutdinova, Elza K, Kim, Sung-Won, Kitahara, Cari M, Koutros, Stella, Kraft, Peter, Kristensen, Vessela N, Kubelka-Sabit, Katerina, Kurian, Allison W, Kwong, Ava, Lacey, James V, Lambrechts, Diether, and Le Marchand, Loic

Subjects
Breast Cancer, Genetics, Clinical Research, Cancer, Aetiology, 2.1 Biological and endogenous factors, Humans, Female, Breast Neoplasms, Genetic Predisposition to Disease, Black People, Genetic Testing, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Formins, Breast cancer susceptibility, Diverse ancestry, Rare variants, Gene regulation, Genome-wide association study, NBCS Collaborators, CTS Consortium, ABCTB Investigators, Clinical Sciences
Abstract

BackgroundLow-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes.MethodsWe evaluated the potential of gene-based aggregation in the Breast Cancer Association Consortium cohorts including 83,471 cases and 59,199 controls. Low-frequency variants were aggregated for individual genes' coding and regulatory regions. Association results in European ancestry samples were compared to single-marker association results in the same cohort. Gene-based associations were also combined in meta-analysis across individuals with European, Asian, African, and Latin American and Hispanic ancestry.ResultsIn European ancestry samples, 14 genes were significantly associated (q

Published
2023

5. Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment

Author

Morra, Anna, Escala-Garcia, Maria, Beesley, Jonathan, Keeman, Renske, Canisius, Sander, Ahearn, Thomas U, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Auer, Paul L, Augustinsson, Annelie, Beane Freeman, Laura E, Becher, Heiko, Beckmann, Matthias W, Behrens, Sabine, Bojesen, Stig E, Bolla, Manjeet K, Brenner, Hermann, Brüning, Thomas, Buys, Saundra S, Caan, Bette, Campa, Daniele, Canzian, Federico, Castelao, Jose E, Chang-Claude, Jenny, Chanock, Stephen J, Cheng, Ting-Yuan David, Clarke, Christine L, Colonna, Sarah V, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, Dennis, Joe, Dörk, Thilo, Dossus, Laure, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Ekici, Arif B, Eliassen, A Heather, Eriksson, Mikael, Evans, D Gareth, Fasching, Peter A, Flyger, Henrik, Fritschi, Lin, Gago-Dominguez, Manuela, García-Sáenz, José A, Giles, Graham G, Grip, Mervi, Guénel, Pascal, Gündert, Melanie, Hahnen, Eric, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hart, Steven N, Hartikainen, Jaana M, Hartmann, Arndt, He, Wei, Hooning, Maartje J, Hoppe, Reiner, Hopper, John L, Howell, Anthony, Hunter, David J, Jager, Agnes, Jakubowska, Anna, Janni, Wolfgang, John, Esther M, Jung, Audrey Y, Kaaks, Rudolf, Keupers, Machteld, Kitahara, Cari M, Koutros, Stella, Kraft, Peter, Kristensen, Vessela N, Kurian, Allison W, Lacey, James V, Lambrechts, Diether, Le Marchand, Loic, Lindblom, Annika, Linet, Martha, Luben, Robert N, Lubiński, Jan, Lush, Michael, Mannermaa, Arto, Manoochehri, Mehdi, Margolin, Sara, Martens, John WM, Martinez, Maria Elena, Mavroudis, Dimitrios, Michailidou, Kyriaki, Milne, Roger L, Mulligan, Anna Marie, Muranen, Taru A, Nevanlinna, Heli, Newman, William G, and Nielsen, Sune F

Subjects
Clinical Research, Cancer, Breast Cancer, Human Genome, Genetics, 2.1 Biological and endogenous factors, Aetiology, Breast Neoplasms, Female, Genome-Wide Association Study, Germ-Line Mutation, Humans, Polymorphism, Single Nucleotide, Prognosis, Survival Analysis, Common germline genetic variants, Breast cancer-specific survival, Patient subgroups, Tumor biology, Systemic treatment, NBCS Collaborators, ABCTB Investigators, kConFab Investigators, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundGiven the high heterogeneity among breast tumors, associations between common germline genetic variants and survival that may exist within specific subgroups could go undetected in an unstratified set of breast cancer patients.MethodsWe performed genome-wide association analyses within 15 subgroups of breast cancer patients based on prognostic factors, including hormone receptors, tumor grade, age, and type of systemic treatment. Analyses were based on 91,686 female patients of European ancestry from the Breast Cancer Association Consortium, including 7531 breast cancer-specific deaths over a median follow-up of 8.1 years. Cox regression was used to assess associations of common germline variants with 15-year and 5-year breast cancer-specific survival. We assessed the probability of these associations being true positives via the Bayesian false discovery probability (BFDP

Published
2021

6. Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis.

Author

Escala-Garcia, Maria, Canisius, Sander, Keeman, Renske, Beesley, Jonathan, Anton-Culver, Hoda, Arndt, Volker, Augustinsson, Annelie, Becher, Heiko, Beckmann, Matthias W, Behrens, Sabine, Bermisheva, Marina, Bojesen, Stig E, Bolla, Manjeet K, Brenner, Hermann, Canzian, Federico, Castelao, Jose E, Chang-Claude, Jenny, Chanock, Stephen J, Couch, Fergus J, Czene, Kamila, Daly, Mary B, Dennis, Joe, Devilee, Peter, Dörk, Thilo, Dunning, Alison M, Easton, Douglas F, Ekici, Arif B, Eliassen, A Heather, Fasching, Peter A, Flyger, Henrik, Gago-Dominguez, Manuela, García-Closas, Montserrat, García-Sáenz, José A, Geisler, Jürgen, Giles, Graham G, Grip, Mervi, Gündert, Melanie, Hahnen, Eric, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hartikainen, Jaana M, Heemskerk-Gerritsen, Bernadette AM, Hollestelle, Antoinette, Hoppe, Reiner, Hopper, John L, Hunter, David J, Jacot, William, Jakubowska, Anna, John, Esther M, Jung, Audrey Y, Kaaks, Rudolf, Khusnutdinova, Elza, Koppert, Linetta B, Kraft, Peter, Kristensen, Vessela N, Kurian, Allison W, Lambrechts, Diether, Le Marchand, Loic, Lindblom, Annika, Luben, Robert N, Lubiński, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Margolin, Sara, Mavroudis, Dimitrios, Muranen, Taru A, Nevanlinna, Heli, Olshan, Andrew F, Olsson, Håkan, Park-Simon, Tjoung-Won, Patel, Alpa V, Peterlongo, Paolo, Pharoah, Paul DP, Punie, Kevin, Radice, Paolo, Rennert, Gad, Rennert, Hedy S, Romero, Atocha, Roylance, Rebecca, Rüdiger, Thomas, Ruebner, Matthias, Saloustros, Emmanouil, Sawyer, Elinor J, Schmutzler, Rita K, Schoemaker, Minouk J, Scott, Christopher, Southey, Melissa C, Surowy, Harald, Swerdlow, Anthony J, Tamimi, Rulla M, Teras, Lauren R, Thomas, Emilie, Tomlinson, Ian, Troester, Melissa A, Vachon, Celine M, Wang, Qin, Winqvist, Robert, and Wolk, Alicja

Subjects
kConFab/AOCS Investigators, Cancer, Genetics, Breast Cancer, Prevention, 2.1 Biological and endogenous factors, 4.1 Discovery and preclinical testing of markers and technologies
Abstract

Breast cancer metastasis accounts for most of the deaths from breast cancer. Identification of germline variants associated with survival in aggressive types of breast cancer may inform understanding of breast cancer progression and assist treatment. In this analysis, we studied the associations between germline variants and breast cancer survival for patients with distant metastases at primary breast cancer diagnosis. We used data from the Breast Cancer Association Consortium (BCAC) including 1062 women of European ancestry with metastatic breast cancer, 606 of whom died of breast cancer. We identified two germline variants on chromosome 1, rs138569520 and rs146023652, significantly associated with breast cancer-specific survival (P = 3.19 × 10-8 and 4.42 × 10-8). In silico analysis suggested a potential regulatory effect of the variants on the nearby target genes SDE2 and H3F3A. However, the variants showed no evidence of association in a smaller replication dataset. The validation dataset was obtained from the SNPs to Risk of Metastasis (StoRM) study and included 293 patients with metastatic primary breast cancer at diagnosis. Ultimately, larger replication studies are needed to confirm the identified associations.

Published
2021

7. Breast Cancer Risk Genes — Association Analysis in More than 113,000 Women

Author

Dorling, Leila, Carvalho, Sara, Allen, Jamie, González-Neira, Anna, Luccarini, Craig, Wahlström, Cecilia, Pooley, Karen A, Parsons, Michael T, Fortuno, Cristina, Wang, Qin, Bolla, Manjeet K, Dennis, Joe, Keeman, Renske, Alonso, M Rosario, Álvarez, Nuria, Herraez, Belen, Fernandez, Victoria, Núñez-Torres, Rocio, Osorio, Ana, Valcich, Jeanette, Li, Minerva, Törngren, Therese, Harrington, Patricia A, Baynes, Caroline, Conroy, Don M, Decker, Brennan, Fachal, Laura, Mavaddat, Nasim, Ahearn, Thomas, Aittomäki, Kristiina, Antonenkova, Natalia N, Arnold, Norbert, Arveux, Patrick, Ausems, Margreet GEM, Auvinen, Päivi, Becher, Heiko, Beckmann, Matthias W, Behrens, Sabine, Bermisheva, Marina, Białkowska, Katarzyna, Blomqvist, Carl, Bogdanova, Natalia V, Bogdanova-Markov, Nadja, Bojesen, Stig E, Bonanni, Bernardo, Børresen-Dale, Anne-Lise, Brauch, Hiltrud, Bremer, Michael, Briceno, Ignacio, Brüning, Thomas, Burwinkel, Barbara, Cameron, David A, Camp, Nicola J, Campbell, Archie, Carracedo, Angel, Castelao, Jose E, Cessna, Melissa H, Chanock, Stephen J, Christiansen, Hans, Collée, J Margriet, Cordina-Duverger, Emilie, Cornelissen, Sten, Czene, Kamila, Dörk, Thilo, Ekici, Arif B, Engel, Christoph, Eriksson, Mikael, Fasching, Peter A, Figueroa, Jonine, Flyger, Henrik, Försti, Asta, Gabrielson, Marike, Gago-Dominguez, Manuela, Georgoulias, Vassilios, Gil, Fabian, Giles, Graham G, Glendon, Gord, Garcia, Encarna B Gómez, Alnæs, Grethe I Grenaker, Guénel, Pascal, Hadjisavvas, Andreas, Haeberle, Lothar, Hahnen, Eric, Hall, Per, Hamann, Ute, Harkness, Elaine F, Hartikainen, Jaana M, Hartman, Mikael, He, Wei, Heemskerk-Gerritsen, Bernadette AM, Hillemanns, Peter, Hogervorst, Frans BL, Hollestelle, Antoinette, Ho, Weang Kee, Hooning, Maartje J, Howell, Anthony, Humphreys, Keith, Idris, Faiza, Jakubowska, Anna, and Jung, Audrey

Subjects
Breast Cancer, Cancer, Genetics, Aetiology, 2.1 Biological and endogenous factors, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Breast Neoplasms, Female, Genetic Predisposition to Disease, Genetic Variation, Humans, Logistic Models, Middle Aged, Mutation, Missense, Odds Ratio, Risk, Sequence Analysis, DNA, Young Adult, Breast Cancer Association Consortium, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundGenetic testing for breast cancer susceptibility is widely used, but for many genes, evidence of an association with breast cancer is weak, underlying risk estimates are imprecise, and reliable subtype-specific risk estimates are lacking.MethodsWe used a panel of 34 putative susceptibility genes to perform sequencing on samples from 60,466 women with breast cancer and 53,461 controls. In separate analyses for protein-truncating variants and rare missense variants in these genes, we estimated odds ratios for breast cancer overall and tumor subtypes. We evaluated missense-variant associations according to domain and classification of pathogenicity.ResultsProtein-truncating variants in 5 genes (ATM, BRCA1, BRCA2, CHEK2, and PALB2) were associated with a risk of breast cancer overall with a P value of less than 0.0001. Protein-truncating variants in 4 other genes (BARD1, RAD51C, RAD51D, and TP53) were associated with a risk of breast cancer overall with a P value of less than 0.05 and a Bayesian false-discovery probability of less than 0.05. For protein-truncating variants in 19 of the remaining 25 genes, the upper limit of the 95% confidence interval of the odds ratio for breast cancer overall was less than 2.0. For protein-truncating variants in ATM and CHEK2, odds ratios were higher for estrogen receptor (ER)-positive disease than for ER-negative disease; for protein-truncating variants in BARD1, BRCA1, BRCA2, PALB2, RAD51C, and RAD51D, odds ratios were higher for ER-negative disease than for ER-positive disease. Rare missense variants (in aggregate) in ATM, CHEK2, and TP53 were associated with a risk of breast cancer overall with a P value of less than 0.001. For BRCA1, BRCA2, and TP53, missense variants (in aggregate) that would be classified as pathogenic according to standard criteria were associated with a risk of breast cancer overall, with the risk being similar to that of protein-truncating variants.ConclusionsThe results of this study define the genes that are most clinically useful for inclusion on panels for the prediction of breast cancer risk, as well as provide estimates of the risks associated with protein-truncating variants, to guide genetic counseling. (Funded by European Union Horizon 2020 programs and others.).

Published
2021

8. Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies?

Author

Park, JooYong, Choi, Ji-Yeob, Choi, Jaesung, Chung, Seokang, Song, Nan, Park, Sue K, Han, Wonshik, Noh, Dong-Young, Ahn, Sei-Hyun, Lee, Jong Won, Kim, Mi Kyung, Jee, Sun Ha, Wen, Wanqing, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Michailidou, Kyriaki, Shah, Mitul, Conroy, Don M, Harrington, Patricia A, Mayes, Rebecca, Czene, Kamila, Hall, Per, Teras, Lauren R, Patel, Alpa V, Couch, Fergus J, Olson, Janet E, Sawyer, Elinor J, Roylance, Rebecca, Bojesen, Stig E, Flyger, Henrik, Lambrechts, Diether, Baten, Adinda, Matsuo, Keitaro, Ito, Hidemi, Guénel, Pascal, Truong, Thérèse, Keeman, Renske, Schmidt, Marjanka K, Wu, Anna H, Tseng, Chiu-Chen, Cox, Angela, Cross, Simon S, kConFab Investigators, Andrulis, Irene L, Hopper, John L, Southey, Melissa C, Wu, Pei-Ei, Shen, Chen-Yang, Fasching, Peter A, Ekici, Arif B, Muir, Kenneth, Lophatananon, Artitaya, Brenner, Hermann, Arndt, Volker, Jones, Michael E, Swerdlow, Anthony J, Hoppe, Reiner, Ko, Yon-Dschun, Hartman, Mikael, Li, Jingmei, Mannermaa, Arto, Hartikainen, Jaana M, Benitez, Javier, González-Neira, Anna, Haiman, Christopher A, Dörk, Thilo, Bogdanova, Natalia V, Teo, Soo Hwang, Mohd Taib, Nur Aishah, Fletcher, Olivia, Johnson, Nichola, Grip, Mervi, Winqvist, Robert, Blomqvist, Carl, Nevanlinna, Heli, Lindblom, Annika, Wendt, Camilla, Kristensen, Vessela N, Nbcs Collaborators, Tollenaar, Rob AEM, Heemskerk-Gerritsen, Bernadette AM, Radice, Paolo, Bonanni, Bernardo, Hamann, Ute, Manoochehri, Mehdi, Lacey, James V, Martinez, Maria Elena, Dunning, Alison M, Pharoah, Paul DP, Easton, Douglas F, Yoo, Keun-Young, and Kang, Daehee

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Women's Health, Clinical Research, Cancer, Estrogen, Breast Cancer, Human Genome, Genetics, Prevention, Aging, 2.1 Biological and endogenous factors, breast cancer, estrogen, gene-environment interaction, Oncology and carcinogenesis
Abstract

In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast cancer cases and 2052 controls in the case-control study, the Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from the 137 candidate genes were included in the GxE analyses with eight established environmental factors. A replication test was conducted by using an independent population from the Breast Cancer Association Consortium (BCAC), with 62,485 Europeans and 9047 Asians. The GxE tests were performed by using two-step methods in GxEScan software. Two interactions were found in the SEBCS. The first interaction was shown between rs13035764 of NCOA1 and age at menarche in the GE|2df model (p-2df = 1.2 × 10-3). The age at menarche before 14 years old was associated with the high risk of breast cancer, and the risk was higher when subjects had homozygous minor allele G. The second GxE was shown between rs851998 near ESR1 and height in the GE|2df model (p-2df = 1.1 × 10-4). Height taller than 160 cm was associated with a high risk of breast cancer, and the risk increased when the minor allele was added. The findings were not replicated in the BCAC. These results would suggest specificity in Koreans for breast cancer risk.

Published
2021

9. Genome-wide association study of germline variants and breast cancer-specific mortality.

Author

Escala-Garcia, Maria, Guo, Qi, Dörk, Thilo, Canisius, Sander, Keeman, Renske, Dennis, Joe, Beesley, Jonathan, Lecarpentier, Julie, Bolla, Manjeet K, Wang, Qin, Abraham, Jean, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Auer, Paul L, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Bernstein, Leslie, Blomqvist, Carl, Boeckx, Bram, Bojesen, Stig E, Bonanni, Bernardo, Børresen-Dale, Anne-Lise, Brauch, Hiltrud, Brenner, Hermann, Brentnall, Adam, Brinton, Louise, Broberg, Per, Brock, Ian W, Brucker, Sara Y, Burwinkel, Barbara, Caldas, Carlos, Caldés, Trinidad, Campa, Daniele, Canzian, Federico, Carracedo, Angel, Carter, Brian D, Castelao, Jose E, Chang-Claude, Jenny, Chanock, Stephen J, Chenevix-Trench, Georgia, Cheng, Ting-Yuan David, Chin, Suet-Feung, Clarke, Christine L, NBCS Collaborators, Cordina-Duverger, Emilie, Couch, Fergus J, Cox, David G, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, Devilee, Peter, Dunn, Janet A, Dunning, Alison M, Durcan, Lorraine, Dwek, Miriam, Earl, Helena M, Ekici, Arif B, Eliassen, A Heather, Ellberg, Carolina, Engel, Christoph, Eriksson, Mikael, Evans, D Gareth, Figueroa, Jonine, Flesch-Janys, Dieter, Flyger, Henrik, Gabrielson, Marike, Gago-Dominguez, Manuela, Galle, Eva, Gapstur, Susan M, García-Closas, Montserrat, García-Sáenz, José A, Gaudet, Mia M, George, Angela, Georgoulias, Vassilios, Giles, Graham G, Glendon, Gord, Goldgar, David E, González-Neira, Anna, Alnæs, Grethe I Grenaker, Grip, Mervi, Guénel, Pascal, Haeberle, Lothar, Hahnen, Eric, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hankinson, Susan, Harkness, Elaine F, Harrington, Patricia A, Hart, Steven N, Hartikainen, Jaana M, Hein, Alexander, Hillemanns, Peter, Hiller, Louise, and Holleczek, Bernd

Subjects
NBCS Collaborators, Chromosomes, Human, Pair 7, Humans, Breast Neoplasms, Receptors, Estrogen, Prognosis, Proportional Hazards Models, Bayes Theorem, Female, Genetic Variation, Genome-Wide Association Study, White People, Genetics, Breast Cancer, Human Genome, Cancer, Aetiology, 2.1 Biological and endogenous factors, Good Health and Well Being, Oncology and Carcinogenesis, Public Health and Health Services, Oncology & Carcinogenesis
Abstract

BackgroundWe examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry.MethodsMeta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the probability of a signal to be a true positive using the Bayesian false discovery probability (BFDP).ResultsWe did not find any variant associated with breast cancer-specific mortality at P

Published
2019

13. PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS

Author

Southey, Melissa C, Goldgar, David E, Winqvist, Robert, Pylkäs, Katri, Couch, Fergus, Tischkowitz, Marc, Foulkes, William D, Dennis, Joe, Michailidou, Kyriaki, van Rensburg, Elizabeth J, Heikkinen, Tuomas, Nevanlinna, Heli, Hopper, John L, Dörk, Thilo, Claes, Kathleen BM, Reis-Filho, Jorge, Teo, Zhi Ling, Radice, Paolo, Catucci, Irene, Peterlongo, Paolo, Tsimiklis, Helen, Odefrey, Fabrice A, Dowty, James G, Schmidt, Marjanka K, Broeks, Annegien, Hogervorst, Frans B, Verhoef, Senno, Carpenter, Jane, Clarke, Christine, Scott, Rodney J, Fasching, Peter A, Haeberle, Lothar, Ekici, Arif B, Beckmann, Matthias W, Peto, Julian, dos-Santos-Silva, Isabel, Fletcher, Olivia, Johnson, Nichola, Bolla, Manjeet K, Sawyer, Elinor J, Tomlinson, Ian, Kerin, Michael J, Miller, Nicola, Marme, Federik, Burwinkel, Barbara, Yang, Rongxi, Guénel, Pascal, Truong, Thérèse, Menegaux, Florence, Sanchez, Marie, Bojesen, Stig, Nielsen, Sune F, Flyger, Henrik, Benitez, Javier, Zamora, M Pilar, Perez, Jose Ignacio Arias, Menéndez, Primitiva, Anton-Culver, Hoda, Neuhausen, Susan, Ziogas, Argyrios, Clarke, Christina A, Brenner, Hermann, Arndt, Volker, Stegmaier, Christa, Brauch, Hiltrud, Brüning, Thomas, Ko, Yon-Dschun, Muranen, Taru A, Aittomäki, Kristiina, Blomqvist, Carl, Bogdanova, Natalia V, Antonenkova, Natalia N, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M, Spurdle, Amanda B, Investigators, kConFab, Group, Australian Ovarian Cancer Study, Wauters, Els, Smeets, Dominiek, Beuselinck, Benoit, Floris, Giuseppe, Chang-Claude, Jenny, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Olson, Janet E, Vachon, Celine, Pankratz, Vernon S, McLean, Catriona, Haiman, Christopher A, Henderson, Brian E, Schumacher, Fredrick, Le Marchand, Loic, Kristensen, Vessela, Alnæs, Grethe Grenaker, and Zheng, Wei

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Oncology and Carcinogenesis, Ovarian Cancer, Aging, Breast Cancer, Cancer, Women's Health, Rare Diseases, Prevention, Urologic Diseases, Aetiology, 2.1 Biological and endogenous factors, Ataxia Telangiectasia Mutated Proteins, Breast Neoplasms, Case-Control Studies, Checkpoint Kinase 2, Fanconi Anemia Complementation Group N Protein, Female, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Male, Mutation, Nuclear Proteins, Ovarian Neoplasms, Prostatic Neoplasms, Risk, Tumor Suppressor Proteins, Australian Ovarian Cancer Study Group, Cancer: breast, Cancer: ovary, Cancer: prostate, cancer predisposition, Medical and Health Sciences, Genetics & Heredity, Clinical sciences
Abstract

BackgroundThe rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are associated with breast cancer risk as high as those associated with rare BRCA2 mutations. We aimed to estimate the relative risks associated with specific rare variants in PALB2, CHEK2 and ATM via a multicentre case-control study.MethodsWe genotyped 10 rare mutations using the custom iCOGS array: PALB2 c.1592delT, c.2816T>G and c.3113G>A, CHEK2 c.349A>G, c.538C>T, c.715G>A, c.1036C>T, c.1312G>T, and c.1343T>G and ATM c.7271T>G. We assessed associations with breast cancer risk (42 671 cases and 42 164 controls), as well as prostate (22 301 cases and 22 320 controls) and ovarian (14 542 cases and 23 491 controls) cancer risk, for each variant.ResultsFor European women, strong evidence of association with breast cancer risk was observed for PALB2 c.1592delT OR 3.44 (95% CI 1.39 to 8.52, p=7.1×10-5), PALB2 c.3113G>A OR 4.21 (95% CI 1.84 to 9.60, p=6.9×10-8) and ATM c.7271T>G OR 11.0 (95% CI 1.42 to 85.7, p=0.0012). We also found evidence of association with breast cancer risk for three variants in CHEK2, c.349A>G OR 2.26 (95% CI 1.29 to 3.95), c.1036C>T OR 5.06 (95% CI 1.09 to 23.5) and c.538C>T OR 1.33 (95% CI 1.05 to 1.67) (p≤0.017). Evidence for prostate cancer risk was observed for CHEK2 c.1343T>G OR 3.03 (95% CI 1.53 to 6.03, p=0.0006) for African men and CHEK2 c.1312G>T OR 2.21 (95% CI 1.06 to 4.63, p=0.030) for European men. No evidence of association with ovarian cancer was found for any of these variants.ConclusionsThis report adds to accumulating evidence that at least some variants in these genes are associated with an increased risk of breast cancer that is clinically important.

Published
2016

14. Differences in polygenic score distributions in European ancestry populations: implications for breast cancer risk prediction

Author

Yiangou, Kristia, primary, Mavaddat, Nasim, additional, Dennis, Joe, additional, Zanti, Maria, additional, Wang, Qin, additional, Bolla, Manjeet K., additional, Abubakar, Mustapha, additional, Ahearn, Thomas U., additional, Andrulis, Irene L., additional, Anton-Culver, Hoda, additional, Antonenkova, Natalia N., additional, Arndt, Volker, additional, Aronson, Kristan J., additional, Augustinsson, Annelie, additional, Baten, Adinda, additional, Behrens, Sabine, additional, Bermisheva, Marina, additional, Berrington de Gonzalez, Amy, additional, Bialkowska, Katarzyna, additional, Boddicker, Nicholas, additional, Bodelon, Clara, additional, Bogdanova, Natalia V., additional, Bojesen, Stig E., additional, Brantley, Kristen D., additional, Brauch, Hiltrud, additional, Brenner, Hermann, additional, Camp, Nicola J., additional, Canzian, Federico, additional, Castelao, Jose E., additional, Cessna, Melissa H., additional, Chang-Claude, Jenny, additional, Chenevix-Trench, Georgia, additional, Chung, Wendy K., additional, Collaborators, NBCS, additional, Colonna, Sarah V., additional, Couch, Fergus J., additional, Cox, Angela, additional, Cross, Simon S., additional, Czene, Kamila, additional, Daly, Mary B., additional, Devilee, Peter, additional, Dork, Thilo, additional, Dunning, Alison M., additional, Eccles, Diana M., additional, Eliassen, A. Heather, additional, Engel, Christoph, additional, Eriksson, Mikael, additional, Evans, D. Gareth, additional, Fasching, Peter A., additional, Fletcher, Olivia, additional, Flyger, Henrik, additional, Fritschi, Lin, additional, Gago-Dominguez, Manuela, additional, Gentry-Maharaj, Aleksandra, additional, Gonzalez-Neira, Anna, additional, Guenel, Pascal, additional, Hahnen, Eric, additional, Haiman, Christopher A., additional, Hamann, Ute, additional, Hartikainen, Jaana M., additional, Ho, Vikki, additional, Hodge, James, additional, Hollestelle, Antoinette, additional, Honisch, Ellen, additional, Hooning, Maartje J., additional, Hoppe, Reiner, additional, Hopper, John L., additional, Howell, Sacha, additional, Howell, Anthony, additional, Investigators, ABCTB, additional, Investigators, kConFab, additional, Jakovchevska, Simona, additional, Jakubowska, Anna, additional, Jernstrom, Helena, additional, Johnson, Nichola, additional, Kaaks, Rudolf, additional, Khusnutdinova, Elza K., additional, Kitahara, Cari M., additional, Koutros, Stella, additional, Kristensen, Vessela N., additional, Lacey, James V., additional, Lambrechts, Diether, additional, Lejbkowicz, Flavio, additional, Lindblom, Annika, additional, Lush, Michael, additional, Mannermaa, Arto, additional, Mavroudis, Dimitrios, additional, Menon, Usha, additional, Murphy, Rachel A., additional, Nevanlinna, Heli, additional, Obi, Nadia, additional, Offit, Kenneth, additional, Park-Simon, Tjoung-Won, additional, Patel, Alpa V., additional, Peng, Cheng, additional, Peterlongo, Paolo, additional, Pita, Guillermo, additional, Plaseska-Karanfilska, Dijana, additional, Pylkas, Katri, additional, Radice, Paolo, additional, Rashid, Muhammad U., additional, Rennert, Gad, additional, Roberts, Eleanor, additional, Rodriguez, Juan, additional, Romero, Atocha, additional, Rosenberg, Efraim H., additional, Saloustros, Emmanouil, additional, Sandler, Dale P., additional, Sawyer, Elinor J., additional, Schmutzler, Rita K., additional, Scott, Christopher G., additional, Shu, Xiao-Ou, additional, Southey, Melissa C., additional, Stone, Jennifer, additional, Taylor, Jack A., additional, Teras, Lauren R., additional, van de Beek, Irma, additional, Willett, Walter, additional, Winqvist, Robert, additional, Zheng, Wei, additional, Vachon, Celine M., additional, Schmidt, Marjanka K., additional, Hall, Per, additional, MacInnis, Robert J., additional, Milne, Roger L., additional, Pharoah, Paul D.P., additional, Simard, Jacques, additional, Antoniou, Antonis C., additional, Easton, Douglas F., additional, and Michailidou, Kyriaki, additional

Published
2024
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15. Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: a pooled analysis of 42,510 cases and 40,577 controls from the Breast Cancer Association Consortium

Author

Lei, Jieping, Rudolph, Anja, Moysich, Kirsten B, Behrens, Sabine, Goode, Ellen L, Bolla, Manjeet K, Dennis, Joe, Dunning, Alison M, Easton, Douglas F, Wang, Qin, Benitez, Javier, Hopper, John L, Southey, Melissa C, Schmidt, Marjanka K, Broeks, Annegien, Fasching, Peter A, Haeberle, Lothar, Peto, Julian, dos-Santos-Silva, Isabel, Sawyer, Elinor J, Tomlinson, Ian, Burwinkel, Barbara, Marmé, Frederik, Guénel, Pascal, Truong, Thérèse, Bojesen, Stig E, Flyger, Henrik, Nielsen, Sune F, Nordestgaard, Børge G, González-Neira, Anna, Menéndez, Primitiva, Anton-Culver, Hoda, Neuhausen, Susan L, Brenner, Hermann, Arndt, Volker, Meindl, Alfons, Schmutzler, Rita K, Brauch, Hiltrud, Hamann, Ute, Nevanlinna, Heli, Fagerholm, Rainer, Dörk, Thilo, Bogdanova, Natalia V, Mannermaa, Arto, Hartikainen, Jaana M, Australian Ovarian Study Group, kConFab Investigators, Van Dijck, Laurien, Smeets, Ann, Flesch-Janys, Dieter, Eilber, Ursula, Radice, Paolo, Peterlongo, Paolo, Couch, Fergus J, Hallberg, Emily, Giles, Graham G, Milne, Roger L, Haiman, Christopher A, Schumacher, Fredrick, Simard, Jacques, Goldberg, Mark S, Kristensen, Vessela, Borresen-Dale, Anne-Lise, Zheng, Wei, Beeghly-Fadiel, Alicia, Winqvist, Robert, Grip, Mervi, Andrulis, Irene L, Glendon, Gord, García-Closas, Montserrat, Figueroa, Jonine, Czene, Kamila, Brand, Judith S, Darabi, Hatef, Eriksson, Mikael, Hall, Per, Li, Jingmei, Cox, Angela, Cross, Simon S, Pharoah, Paul DP, Shah, Mitul, Kabisch, Maria, Torres, Diana, Jakubowska, Anna, Lubinski, Jan, Ademuyiwa, Foluso, Ambrosone, Christine B, Swerdlow, Anthony, Jones, Michael, and Chang-Claude, Jenny

Subjects
Breast Cancer, Genetics, Human Genome, Cancer, 2.1 Biological and endogenous factors, Aetiology, Breast Neoplasms, Case-Control Studies, Female, Genetic Predisposition to Disease, Humans, Immune Tolerance, Polymorphism, Single Nucleotide, Australian Ovarian Study Group, kConFab Investigators, Complementary and Alternative Medicine, Paediatrics and Reproductive Medicine, Genetics & Heredity
Abstract

Immunosuppression plays a pivotal role in assisting tumors to evade immune destruction and promoting tumor development. We hypothesized that genetic variation in the immunosuppression pathway genes may be implicated in breast cancer tumorigenesis. We included 42,510 female breast cancer cases and 40,577 controls of European ancestry from 37 studies in the Breast Cancer Association Consortium (2015) with available genotype data for 3595 single nucleotide polymorphisms (SNPs) in 133 candidate genes. Associations between genotyped SNPs and overall breast cancer risk, and secondarily according to estrogen receptor (ER) status, were assessed using multiple logistic regression models. Gene-level associations were assessed based on principal component analysis. Gene expression analyses were conducted using RNA sequencing level 3 data from The Cancer Genome Atlas for 989 breast tumor samples and 113 matched normal tissue samples. SNP rs1905339 (A>G) in the STAT3 region was associated with an increased breast cancer risk (per allele odds ratio 1.05, 95 % confidence interval 1.03-1.08; p value = 1.4 × 10(-6)). The association did not differ significantly by ER status. On the gene level, in addition to TGFBR2 and CCND1, IL5 and GM-CSF showed the strongest associations with overall breast cancer risk (p value = 1.0 × 10(-3) and 7.0 × 10(-3), respectively). Furthermore, STAT3 and IL5 but not GM-CSF were differentially expressed between breast tumor tissue and normal tissue (p value = 2.5 × 10(-3), 4.5 × 10(-4) and 0.63, respectively). Our data provide evidence that the immunosuppression pathway genes STAT3, IL5, and GM-CSF may be novel susceptibility loci for breast cancer in women of European ancestry.

Published
2016

16. RAD51B in Familial Breast Cancer.

Author

Pelttari, Liisa M, Khan, Sofia, Vuorela, Mikko, Kiiski, Johanna I, Vilske, Sara, Nevanlinna, Viivi, Ranta, Salla, Schleutker, Johanna, Winqvist, Robert, Kallioniemi, Anne, Dörk, Thilo, Bogdanova, Natalia V, Figueroa, Jonine, Pharoah, Paul DP, Schmidt, Marjanka K, Dunning, Alison M, García-Closas, Montserrat, Bolla, Manjeet K, Dennis, Joe, Michailidou, Kyriaki, Wang, Qin, Hopper, John L, Southey, Melissa C, Rosenberg, Efraim H, Fasching, Peter A, Beckmann, Matthias W, Peto, Julian, Dos-Santos-Silva, Isabel, Sawyer, Elinor J, Tomlinson, Ian, Burwinkel, Barbara, Surowy, Harald, Guénel, Pascal, Truong, Thérèse, Bojesen, Stig E, Nordestgaard, Børge G, Benitez, Javier, González-Neira, Anna, Neuhausen, Susan L, Anton-Culver, Hoda, Brenner, Hermann, Arndt, Volker, Meindl, Alfons, Schmutzler, Rita K, Brauch, Hiltrud, Brüning, Thomas, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Hartikainen, Jaana M, Chenevix-Trench, Georgia, kConFab/AOCS Investigators, Van Dyck, Laurien, Janssen, Hilde, Chang-Claude, Jenny, Rudolph, Anja, Radice, Paolo, Peterlongo, Paolo, Hallberg, Emily, Olson, Janet E, Giles, Graham G, Milne, Roger L, Haiman, Christopher A, Schumacher, Fredrick, Simard, Jacques, Dumont, Martine, Kristensen, Vessela, Borresen-Dale, Anne-Lise, Zheng, Wei, Beeghly-Fadiel, Alicia, Grip, Mervi, Andrulis, Irene L, Glendon, Gord, Devilee, Peter, Seynaeve, Caroline, Hooning, Maartje J, Collée, Margriet, Cox, Angela, Cross, Simon S, Shah, Mitul, Luben, Robert N, Hamann, Ute, Torres, Diana, Jakubowska, Anna, Lubinski, Jan, Couch, Fergus J, Yannoukakos, Drakoulis, Orr, Nick, Swerdlow, Anthony, Darabi, Hatef, Li, Jingmei, Czene, Kamila, Hall, Per, Easton, Douglas F, Mattson, Johanna, Blomqvist, Carl, Aittomäki, Kristiina, and Nevanlinna, Heli

Subjects
kConFab/AOCS Investigators, Humans, Breast Neoplasms, Genetic Predisposition to Disease, DNA-Binding Proteins, Haplotypes, Heterozygote, Mutation, Missense, Polymorphism, Single Nucleotide, Middle Aged, Finland, Female, Male, Genotyping Techniques, General Science & Technology
Abstract

Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 with the risk of female breast cancer and rs1314913 with the risk of male breast cancer. The aim of this study was to investigate the role of RAD51B variants in breast cancer predisposition, particularly in the context of familial breast cancer in Finland. We sequenced the coding region of RAD51B in 168 Finnish breast cancer patients from the Helsinki region for identification of possible recurrent founder mutations. In addition, we studied the known rs999737, rs2588809, and rs1314913 SNPs and RAD51B haplotypes in 44,791 breast cancer cases and 43,583 controls from 40 studies participating in the Breast Cancer Association Consortium (BCAC) that were genotyped on a custom chip (iCOGS). We identified one putatively pathogenic missense mutation c.541C>T among the Finnish cancer patients and subsequently genotyped the mutation in additional breast cancer cases (n = 5259) and population controls (n = 3586) from Finland and Belarus. No significant association with breast cancer risk was seen in the meta-analysis of the Finnish datasets or in the large BCAC dataset. The association with previously identified risk variants rs999737, rs2588809, and rs1314913 was replicated among all breast cancer cases and also among familial cases in the BCAC dataset. The most significant association was observed for the haplotype carrying the risk-alleles of all the three SNPs both among all cases (odds ratio (OR): 1.15, 95% confidence interval (CI): 1.11-1.19, P = 8.88 x 10-16) and among familial cases (OR: 1.24, 95% CI: 1.16-1.32, P = 6.19 x 10-11), compared to the haplotype with the respective protective alleles. Our results suggest that loss-of-function mutations in RAD51B are rare, but common variation at the RAD51B region is significantly associated with familial breast cancer risk.

Published
2016

17. Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2.

Author

Orr, Nick, Dudbridge, Frank, Dryden, Nicola, Maguire, Sarah, Novo, Daniela, Perrakis, Eleni, Johnson, Nichola, Ghoussaini, Maya, Hopper, John L, Southey, Melissa C, Apicella, Carmel, Stone, Jennifer, Schmidt, Marjanka K, Broeks, Annegien, Van't Veer, Laura J, Hogervorst, Frans B, Fasching, Peter A, Haeberle, Lothar, Ekici, Arif B, Beckmann, Matthias W, Gibson, Lorna, Aitken, Zoe, Warren, Helen, Sawyer, Elinor, Tomlinson, Ian, Kerin, Michael J, Miller, Nicola, Burwinkel, Barbara, Marme, Frederik, Schneeweiss, Andreas, Sohn, Chistof, Guénel, Pascal, Truong, Thérèse, Cordina-Duverger, Emilie, Sanchez, Marie, Bojesen, Stig E, Nordestgaard, Børge G, Nielsen, Sune F, Flyger, Henrik, Benitez, Javier, Zamora, Maria Pilar, Arias Perez, Jose Ignacio, Menéndez, Primitiva, Anton-Culver, Hoda, Neuhausen, Susan L, Brenner, Hermann, Dieffenbach, Aida Karina, Arndt, Volker, Stegmaier, Christa, Hamann, Ute, Brauch, Hiltrud, Justenhoven, Christina, Brüning, Thomas, Ko, Yon-Dschun, Nevanlinna, Heli, Aittomäki, Kristiina, Blomqvist, Carl, Khan, Sofia, Bogdanova, Natalia, Dörk, Thilo, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M, Chenevix-Trench, Georgia, Beesley, Jonathan, Lambrechts, Diether, Moisse, Matthieu, Floris, Guiseppe, Beuselinck, Benoit, Chang-Claude, Jenny, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Radice, Paolo, Peterlongo, Paolo, Peissel, Bernard, Pensotti, Valeria, Couch, Fergus J, Olson, Janet E, Slettedahl, Seth, Vachon, Celine, Giles, Graham G, Milne, Roger L, McLean, Catriona, Haiman, Christopher A, Henderson, Brian E, Schumacher, Fredrick, Le Marchand, Loic, Simard, Jacques, Goldberg, Mark S, Labrèche, France, Dumont, Martine, Kristensen, Vessela, Alnæs, Grethe Grenaker, Nord, Silje, Borresen-Dale, Anne-Lise, and Zheng, Wei

Subjects
GENICA Network, kConFab Investigators, Australian Ovarian Cancer Study Group, Chromosomes, Human, Pair 9, Humans, Breast Neoplasms, Genetic Predisposition to Disease, Estrogen Receptor alpha, Risk, Chromosome Mapping, Polymorphism, Single Nucleotide, Adult, Aged, Middle Aged, Female, GATA3 Transcription Factor, Hepatocyte Nuclear Factor 3-alpha, Kruppel-Like Transcription Factors, Enhancer Elements, Genetic, Genetic Loci, Genetic Association Studies, Kruppel-Like Factor 4, Asian People, White People, Cancer, Breast Cancer, Biotechnology, Genetics, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

We recently identified a novel susceptibility variant, rs865686, for estrogen-receptor positive breast cancer at 9q31.2. Here, we report a fine-mapping analysis of the 9q31.2 susceptibility locus using 43 160 cases and 42 600 controls of European ancestry ascertained from 52 studies and a further 5795 cases and 6624 controls of Asian ancestry from nine studies. Single nucleotide polymorphism (SNP) rs676256 was most strongly associated with risk in Europeans (odds ratios [OR] = 0.90 [0.88-0.92]; P-value = 1.58 × 10(-25)). This SNP is one of a cluster of highly correlated variants, including rs865686, that spans ∼14.5 kb. We identified two additional independent association signals demarcated by SNPs rs10816625 (OR = 1.12 [1.08-1.17]; P-value = 7.89 × 10(-09)) and rs13294895 (OR = 1.09 [1.06-1.12]; P-value = 2.97 × 10(-11)). SNP rs10816625, but not rs13294895, was also associated with risk of breast cancer in Asian individuals (OR = 1.12 [1.06-1.18]; P-value = 2.77 × 10(-05)). Functional genomic annotation using data derived from breast cancer cell-line models indicates that these SNPs localise to putative enhancer elements that bind known drivers of hormone-dependent breast cancer, including ER-α, FOXA1 and GATA-3. In vitro analyses indicate that rs10816625 and rs13294895 have allele-specific effects on enhancer activity and suggest chromatin interactions with the KLF4 gene locus. These results demonstrate the power of dense genotyping in large studies to identify independent susceptibility variants. Analysis of associations using subjects with different ancestry, combined with bioinformatic and genomic characterisation, can provide strong evidence for the likely causative alleles and their functional basis.

Published
2015

18. Investigation of gene‐environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors

Author

Rudolph, Anja, Milne, Roger L, Truong, Thérèse, Knight, Julia A, Seibold, Petra, Flesch‐Janys, Dieter, Behrens, Sabine, Eilber, Ursula, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Dunning, Alison M, Shah, Mitul, Munday, Hannah R, Darabi, Hatef, Eriksson, Mikael, Brand, Judith S, Olson, Janet, Vachon, Celine M, Hallberg, Emily, Castelao, J Esteban, Carracedo, Angel, Torres, Maria, Li, Jingmei, Humphreys, Keith, Cordina‐Duverger, Emilie, Menegaux, Florence, Flyger, Henrik, Nordestgaard, Børge G, Nielsen, Sune F, Yesilyurt, Betul T, Floris, Giuseppe, Leunen, Karin, Engelhardt, Ellen G, Broeks, Annegien, Rutgers, Emiel J, Glendon, Gord, Mulligan, Anna Marie, Cross, Simon, Reed, Malcolm, Gonzalez‐Neira, Anna, Perez, José Ignacio Arias, Provenzano, Elena, Apicella, Carmel, Southey, Melissa C, Spurdle, Amanda, Investigators, kConFab, Group, AOCS, Häberle, Lothar, Beckmann, Matthias W, Ekici, Arif B, Dieffenbach, Aida Karina, Arndt, Volker, Stegmaier, Christa, McLean, Catriona, Baglietto, Laura, Chanock, Stephen J, Lissowska, Jolanta, Sherman, Mark E, Brüning, Thomas, Hamann, Ute, Ko, Yon‐Dschun, Orr, Nick, Schoemaker, Minouk, Ashworth, Alan, Kosma, Veli‐Matti, Kataja, Vesa, Hartikainen, Jaana M, Mannermaa, Arto, Swerdlow, Anthony, GENICA‐Network, Giles, Graham G, Brenner, Hermann, Fasching, Peter A, Chenevix‐Trench, Georgia, Hopper, John, Benítez, Javier, Cox, Angela, Andrulis, Irene L, Lambrechts, Diether, Gago‐Dominguez, Manuela, Couch, Fergus, Czene, Kamila, Bojesen, Stig E, Easton, Doug F, Schmidt, Marjanka K, Guénel, Pascal, Hall, Per, Pharoah, Paul DP, Garcia‐Closas, Montserrat, and Chang‐Claude, Jenny

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Breast Cancer, Aging, Prevention, Genetics, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Breast Neoplasms, Female, Gene-Environment Interaction, Genetic Loci, Genetic Predisposition to Disease, Humans, Polymorphism, Single Nucleotide, Receptors, Estrogen, Risk Factors, gene-environment interaction, breast cancer, risk factor, genetic susceptibility, kConFab Investigators, AOCS Group, GENICA-Network, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

A large genotyping project within the Breast Cancer Association Consortium (BCAC) recently identified 41 associations between single nucleotide polymorphisms (SNPs) and overall breast cancer (BC) risk. We investigated whether the effects of these 41 SNPs, as well as six SNPs associated with estrogen receptor (ER) negative BC risk are modified by 13 environmental risk factors for BC. Data from 22 studies participating in BCAC were pooled, comprising up to 26,633 cases and 30,119 controls. Interactions between SNPs and environmental factors were evaluated using an empirical Bayes-type shrinkage estimator. Six SNPs showed interactions with associated p-values (pint )

Published
2015

19. Fine-Scale Mapping of the 5q11.2 Breast Cancer Locus Reveals at Least Three Independent Risk Variants Regulating MAP3K1

Author

Glubb, Dylan M, Maranian, Mel J, Michailidou, Kyriaki, Pooley, Karen A, Meyer, Kerstin B, Kar, Siddhartha, Carlebur, Saskia, O’Reilly, Martin, Betts, Joshua A, Hillman, Kristine M, Kaufmann, Susanne, Beesley, Jonathan, Canisius, Sander, Hopper, John L, Southey, Melissa C, Tsimiklis, Helen, Apicella, Carmel, Schmidt, Marjanka K, Broeks, Annegien, Hogervorst, Frans B, van der Schoot, C Ellen, Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Fasching, Peter A, Ruebner, Matthias, Ekici, Arif B, Beckmann, Matthias W, Peto, Julian, dos-Santos-Silva, Isabel, Fletcher, Olivia, Johnson, Nichola, Pharoah, Paul DP, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Sawyer, Elinor J, Tomlinson, Ian, Kerin, Michael J, Miller, Nicola, Burwinkel, Barbara, Marme, Frederik, Yang, Rongxi, Surowy, Harald, Guénel, Pascal, Truong, Thérèse, Menegaux, Florence, Sanchez, Marie, Bojesen, Stig E, Nordestgaard, Børge G, Nielsen, Sune F, Flyger, Henrik, González-Neira, Anna, Benitez, Javier, Zamora, M Pilar, Perez, Jose Ignacio Arias, Anton-Culver, Hoda, Neuhausen, Susan L, Brenner, Hermann, Dieffenbach, Aida Karina, Arndt, Volker, Stegmaier, Christa, Meindl, Alfons, Schmutzler, Rita K, Brauch, Hiltrud, Ko, Yon-Dschun, Brüning, Thomas, Network, The GENICA, Nevanlinna, Heli, Muranen, Taru A, Aittomäki, Kristiina, Blomqvist, Carl, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Tanaka, Hideo, Dörk, Thilo, Bogdanova, Natalia V, Helbig, Sonja, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M, Investigators, kConFab, Wu, Anna H, Tseng, Chiu-chen, Van Den Berg, David, Stram, Daniel O, Lambrechts, Diether, Zhao, Hui, Weltens, Caroline, van Limbergen, Erik, Chang-Claude, Jenny, Flesch-Janys, Dieter, Rudolph, Anja, Seibold, Petra, and Radice, Paolo

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Oncology and Carcinogenesis, Human Genome, Prevention, Breast Cancer, Cancer, Estrogen, 2.1 Biological and endogenous factors, Aetiology, Alleles, Breast Neoplasms, Case-Control Studies, Cell Line, Tumor, Chromosome Mapping, Chromosomes, Human, Pair 5, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotyping Techniques, Humans, MAP Kinase Kinase Kinase 1, MCF-7 Cells, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Quantitative Trait Loci, Racial Groups, Risk Factors, GENICA Network, kConFab Investigators, Norwegian Breast Cancer Study, Medical and Health Sciences, Genetics & Heredity, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Genome-wide association studies (GWASs) have revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of European ancestry. In an attempt to identify the biologically relevant variants, we analyzed 909 genetic variants across 5q11.2 in 103,991 breast cancer individuals and control individuals from 52 studies in the Breast Cancer Association Consortium. Multiple logistic regression analyses identified three independent risk signals: the strongest associations were with 15 correlated variants (iCHAV1), where the minor allele of the best candidate, rs62355902, associated with significantly increased risks of both estrogen-receptor-positive (ER(+): odds ratio [OR] = 1.24, 95% confidence interval [CI] = 1.21-1.27, ptrend = 5.7 × 10(-44)) and estrogen-receptor-negative (ER(-): OR = 1.10, 95% CI = 1.05-1.15, ptrend = 3.0 × 10(-4)) tumors. After adjustment for rs62355902, we found evidence of association of a further 173 variants (iCHAV2) containing three subsets with a range of effects (the strongest was rs113317823 [pcond = 1.61 × 10(-5)]) and five variants composing iCHAV3 (lead rs11949391; ER(+): OR = 0.90, 95% CI = 0.87-0.93, pcond = 1.4 × 10(-4)). Twenty-six percent of the prioritized candidate variants coincided with four putative regulatory elements that interact with the MAP3K1 promoter through chromatin looping and affect MAP3K1 promoter activity. Functional analysis indicated that the cancer risk alleles of four candidates (rs74345699 and rs62355900 [iCHAV1], rs16886397 [iCHAV2a], and rs17432750 [iCHAV3]) increased MAP3K1 transcriptional activity. Chromatin immunoprecipitation analysis revealed diminished GATA3 binding to the minor (cancer-protective) allele of rs17432750, indicating a mechanism for its action. We propose that the cancer risk alleles act to increase MAP3K1 expression in vivo and might promote breast cancer cell survival.

Published
2015

20. Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk.

Author

Lin, Wei-Yu, Camp, Nicola J, Ghoussaini, Maya, Beesley, Jonathan, Michailidou, Kyriaki, Hopper, John L, Apicella, Carmel, Southey, Melissa C, Stone, Jennifer, Schmidt, Marjanka K, Broeks, Annegien, Van't Veer, Laura J, Th Rutgers, Emiel J, Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Fasching, Peter A, Haeberle, Lothar, Ekici, Arif B, Beckmann, Matthias W, Peto, Julian, Dos-Santos-Silva, Isabel, Fletcher, Olivia, Johnson, Nichola, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Sawyer, Elinor J, Cheng, Timothy, Tomlinson, Ian, Kerin, Michael J, Miller, Nicola, Marmé, Frederik, Surowy, Harald M, Burwinkel, Barbara, Guénel, Pascal, Truong, Thérèse, Menegaux, Florence, Mulot, Claire, Bojesen, Stig E, Nordestgaard, Børge G, Nielsen, Sune F, Flyger, Henrik, Benitez, Javier, Zamora, M Pilar, Arias Perez, Jose Ignacio, Menéndez, Primitiva, González-Neira, Anna, Pita, Guillermo, Alonso, M Rosario, Alvarez, Nuria, Herrero, Daniel, Anton-Culver, Hoda, Brenner, Hermann, Dieffenbach, Aida Karina, Arndt, Volker, Stegmaier, Christa, Meindl, Alfons, Lichtner, Peter, Schmutzler, Rita K, Müller-Myhsok, Bertram, Brauch, Hiltrud, Brüning, Thomas, Ko, Yon-Dschun, GENICA Network, Tessier, Daniel C, Vincent, Daniel, Bacot, Francois, Nevanlinna, Heli, Aittomäki, Kristiina, Blomqvist, Carl, Khan, Sofia, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Horio, Akiyo, Bogdanova, Natalia V, Antonenkova, Natalia N, Dörk, Thilo, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M, kConFab Investigators, Australian Ovarian Cancer Study Group, Wu, Anna H, Tseng, Chiu-Chen, Van Den Berg, David, Stram, Daniel O, Neven, Patrick, Wauters, Els, Wildiers, Hans, Lambrechts, Diether, Chang-Claude, Jenny, Rudolph, Anja, Seibold, Petra, and Flesch-Janys, Dieter

Subjects
GENICA Network, kConFab Investigators, Australian Ovarian Cancer Study Group, Breast and Ovarian Cancer Susceptibility (BOCS) Study, Chromosomes, Human, Pair 2, Humans, Breast Neoplasms, Genetic Predisposition to Disease, Proteins, Case-Control Studies, Polymorphism, Single Nucleotide, European Continental Ancestry Group, Female, Caspase 8, CASP8 and FADD-Like Apoptosis Regulating Protein, Genome-Wide Association Study, Genotyping Techniques, Chromosomes, Human, Pair 2, Polymorphism, Single Nucleotide, Prevention, Genetics, Human Genome, Breast Cancer, Cancer, Biotechnology, 2.1 Biological and endogenous factors, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

Previous studies have suggested that polymorphisms in CASP8 on chromosome 2 are associated with breast cancer risk. To clarify the role of CASP8 in breast cancer susceptibility, we carried out dense genotyping of this region in the Breast Cancer Association Consortium (BCAC). Single-nucleotide polymorphisms (SNPs) spanning a 1 Mb region around CASP8 were genotyped in 46 450 breast cancer cases and 42 600 controls of European origin from 41 studies participating in the BCAC as part of a custom genotyping array experiment (iCOGS). Missing genotypes and SNPs were imputed and, after quality exclusions, 501 typed and 1232 imputed SNPs were included in logistic regression models adjusting for study and ancestry principal components. The SNPs retained in the final model were investigated further in data from nine genome-wide association studies (GWAS) comprising in total 10 052 case and 12 575 control subjects. The most significant association signal observed in European subjects was for the imputed intronic SNP rs1830298 in ALS2CR12 (telomeric to CASP8), with per allele odds ratio and 95% confidence interval [OR (95% confidence interval, CI)] for the minor allele of 1.05 (1.03-1.07), P = 1 × 10(-5). Three additional independent signals from intronic SNPs were identified, in CASP8 (rs36043647), ALS2CR11 (rs59278883) and CFLAR (rs7558475). The association with rs1830298 was replicated in the imputed results from the combined GWAS (P = 3 × 10(-6)), yielding a combined OR (95% CI) of 1.06 (1.04-1.08), P = 1 × 10(-9). Analyses of gene expression associations in peripheral blood and normal breast tissue indicate that CASP8 might be the target gene, suggesting a mechanism involving apoptosis.

Published
2015

22. Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade.

Author

Purrington, Kristen S, Slettedahl, Seth, Bolla, Manjeet K, Michailidou, Kyriaki, Czene, Kamila, Nevanlinna, Heli, Bojesen, Stig E, Andrulis, Irene L, Cox, Angela, Hall, Per, Carpenter, Jane, Yannoukakos, Drakoulis, Haiman, Christopher A, Fasching, Peter A, Mannermaa, Arto, Winqvist, Robert, Brenner, Hermann, Lindblom, Annika, Chenevix-Trench, Georgia, Benitez, Javier, Swerdlow, Anthony, Kristensen, Vessela, Guénel, Pascal, Meindl, Alfons, Darabi, Hatef, Eriksson, Mikael, Fagerholm, Rainer, Aittomäki, Kristiina, Blomqvist, Carl, Nordestgaard, Børge G, Nielsen, Sune F, Flyger, Henrik, Wang, Xianshu, Olswold, Curtis, Olson, Janet E, Mulligan, Anna Marie, Knight, Julia A, Tchatchou, Sandrine, Reed, Malcolm WR, Cross, Simon S, Liu, Jianjun, Li, Jingmei, Humphreys, Keith, Clarke, Christine, Scott, Rodney, ABCTB Investigators, Fostira, Florentia, Fountzilas, George, Konstantopoulou, Irene, Henderson, Brian E, Schumacher, Fredrick, Le Marchand, Loic, Ekici, Arif B, Hartmann, Arndt, Beckmann, Matthias W, Hartikainen, Jaana M, Kosma, Veli-Matti, Kataja, Vesa, Jukkola-Vuorinen, Arja, Pylkäs, Katri, Kauppila, Saila, Dieffenbach, Aida Karina, Stegmaier, Christa, Arndt, Volker, Margolin, Sara, Australian Ovarian Cancer Study Group, kConFab Investigators, Balleine, Rosemary, Arias Perez, Jose Ignacio, Pilar Zamora, M, Menéndez, Primitiva, Ashworth, Alan, Jones, Michael, Orr, Nick, Arveux, Patrick, Kerbrat, Pierre, Truong, Thérèse, Bugert, Peter, Toland, Amanda E, Ambrosone, Christine B, Labrèche, France, Goldberg, Mark S, Dumont, Martine, Ziogas, Argyrios, Lee, Eunjung, Dite, Gillian S, Apicella, Carmel, Southey, Melissa C, Long, Jirong, Shrubsole, Martha, Deming-Halverson, Sandra, Ficarazzi, Filomena, Barile, Monica, Peterlongo, Paolo, Durda, Katarzyna, Jaworska-Bieniek, Katarzyna, Tollenaar, Robert AEM, Seynaeve, Caroline, GENICA Network, and Brüning, Thomas

Subjects
ABCTB Investigators, Australian Ovarian Cancer Study Group, kConFab Investigators, GENICA Network, Humans, Breast Neoplasms, Carrier Proteins, Tumor Suppressor Proteins, Neoplasm Staging, Risk Factors, Case-Control Studies, Haplotypes, Polymorphism, Single Nucleotide, Female, Receptor, Fibroblast Growth Factor, Type 2, Genetic Variation, Genetics, Breast Cancer, Prevention, Human Genome, Cancer, Biotechnology, Aetiology, 2.1 Biological and endogenous factors, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

Mitotic index is an important component of histologic grade and has an etiologic role in breast tumorigenesis. Several small candidate gene studies have reported associations between variation in mitotic genes and breast cancer risk. We measured associations between 2156 single nucleotide polymorphisms (SNPs) from 194 mitotic genes and breast cancer risk, overall and by histologic grade, in the Breast Cancer Association Consortium (BCAC) iCOGS study (n = 39 067 cases; n = 42 106 controls). SNPs in TACC2 [rs17550038: odds ratio (OR) = 1.24, 95% confidence interval (CI) 1.16-1.33, P = 4.2 × 10(-10)) and EIF3H (rs799890: OR = 1.07, 95% CI 1.04-1.11, P = 8.7 × 10(-6)) were significantly associated with risk of low-grade breast cancer. The TACC2 signal was retained (rs17550038: OR = 1.15, 95% CI 1.07-1.23, P = 7.9 × 10(-5)) after adjustment for breast cancer risk SNPs in the nearby FGFR2 gene, suggesting that TACC2 is a novel, independent genome-wide significant genetic risk locus for low-grade breast cancer. While no SNPs were individually associated with high-grade disease, a pathway-level gene set analysis showed that variation across the 194 mitotic genes was associated with high-grade breast cancer risk (P = 2.1 × 10(-3)). These observations will provide insight into the contribution of mitotic defects to histological grade and the etiology of breast cancer.

Published
2014

23. Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study.

Author

Johnson, Nichola, Dudbridge, Frank, Orr, Nick, Gibson, Lorna, Jones, Michael E, Schoemaker, Minouk J, Folkerd, Elizabeth J, Haynes, Ben P, Hopper, John L, Southey, Melissa C, Dite, Gillian S, Apicella, Carmel, Schmidt, Marjanka K, Broeks, Annegien, Van't Veer, Laura J, Atsma, Femke, Muir, Kenneth, Lophatananon, Artitaya, Fasching, Peter A, Beckmann, Matthias W, Ekici, Arif B, Renner, Stefan P, Sawyer, Elinor, Tomlinson, Ian, Kerin, Michael, Miller, Nicola, Burwinkel, Barbara, Marme, Frederik, Schneeweiss, Andreas, Sohn, Christof, Guénel, Pascal, Truong, Therese, Cordina, Emilie, Menegaux, Florence, Bojesen, Stig E, Nordestgaard, Børge G, Flyger, Henrik, Milne, Roger, Zamora, M Pilar, Arias Perez, Jose Ignacio, Benitez, Javier, Bernstein, Leslie, Anton-Culver, Hoda, Ziogas, Argyrios, Clarke Dur, Christina, Brenner, Hermann, Müller, Heiko, Arndt, Volker, Dieffenbach, Aida Karina, Meindl, Alfons, Heil, Joerg, Bartram, Claus R, Schmutzler, Rita K, Brauch, Hiltrud, Justenhoven, Christina, Ko, Yon-Dschun, GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network, Nevanlinna, Heli, Muranen, Taru A, Aittomäki, Kristiina, Blomqvist, Carl, Matsuo, Keitaro, Dörk, Thilo, Bogdanova, Natalia V, Antonenkova, Natalia N, Lindblom, Annika, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M, Chenevix-Trench, Georgia, Beesley, Jonathan, kConFab Investigators, Australian Ovarian Cancer Study Group, Wu, Anna H, Van den Berg, David, Tseng, Chiu-Chen, Lambrechts, Diether, Smeets, Dominiek, Neven, Patrick, Wildiers, Hans, Chang-Claude, Jenny, Rudolph, Anja, Nickels, Stefan, Flesch-Janys, Dieter, Radice, Paolo, Peterlongo, Paolo, Bonanni, Bernardo, Pensotti, Valeria, Couch, Fergus J, Olson, Janet E, Wang, Xianshu, Fredericksen, Zachary, Pankratz, Vernon S, Giles, Graham G, Severi, Gianluca, Baglietto, Laura, Haiman, Chris, Simard, Jacques, and Goldberg, Mark S

Subjects
GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network, kConFab Investigators, Australian Ovarian Cancer Study Group, Humans, Breast Neoplasms, Genetic Predisposition to Disease, Reproductive History, Risk Factors, Age Factors, Age of Onset, Premenopause, Menarche, Genotype, Polymorphism, Single Nucleotide, Adult, Aged, Middle Aged, European Continental Ancestry Group, Female, Cytochrome P-450 CYP3A, Genetic Association Studies, Human Genome, Aging, Clinical Research, Cancer, Genetics, Breast Cancer, Oncology & Carcinogenesis, Oncology and Carcinogenesis
Abstract

IntroductionWe have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years.MethodsWe further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics.ResultsWe confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; P = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; P = 0.004), respectively (P(trend) = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (P(trend) = 0.005) but not cases (P(trend) = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (P(het) = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (OR(het) = 0.84, 95% CI 0.75, 0.94; OR(hom) = 0.81, 95% CI 0.51, 1.30; P(trend) = 0.002) but not for those who had their menarche age ≤11 years (OR(het) = 1.06, 95% CI 0.95, 1.19, OR(hom) = 1.07, 95% CI 0.67, 1.72; P(trend) = 0.29).ConclusionsTo our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.

Published
2014

24. Identification of New Genetic Susceptibility Loci for Breast Cancer Through Consideration of Gene‐Environment Interactions

Author

Schoeps, Anja, Rudolph, Anja, Seibold, Petra, Dunning, Alison M, Milne, Roger L, Bojesen, Stig E, Swerdlow, Anthony, Andrulis, Irene, Brenner, Hermann, Behrens, Sabine, Orr, Nicholas, Jones, Michael, Ashworth, Alan, Li, Jingmei, Cramp, Helen, Connley, Dan, Czene, Kamila, Darabi, Hatef, Chanock, Stephen J, Lissowska, Jolanta, Figueroa, Jonine D, Knight, Julia, Glendon, Gord, Mulligan, Anna M, Dumont, Martine, Severi, Gianluca, Baglietto, Laura, Olson, Janet, Vachon, Celine, Purrington, Kristen, Moisse, Matthieu, Neven, Patrick, Wildiers, Hans, Spurdle, Amanda, Kosma, Veli‐Matti, Kataja, Vesa, Hartikainen, Jaana M, Hamann, Ute, Ko, Yon‐Dschun, Dieffenbach, Aida K, Arndt, Volker, Stegmaier, Christa, Malats, Núria, Perez, José I Arias, Benítez, Javier, Flyger, Henrik, Nordestgaard, Børge G, Truong, Thérèse, Cordina‐Duverger, Emilie, Menegaux, Florence, dos Santos Silva, Isabel, Fletcher, Olivia, Johnson, Nichola, Häberle, Lothar, Beckmann, Matthias W, Ekici, Arif B, Braaf, Linde, Atsma, Femke, Broek, Alexandra J den, Makalic, Enes, Schmidt, Daniel F, Southey, Melissa C, Cox, Angela, Simard, Jacques, Giles, Graham G, Lambrechts, Diether, Mannermaa, Arto, Brauch, Hiltrud, Guénel, Pascal, Peto, Julian, Fasching, Peter A, Hopper, John, Flesch‐Janys, Dieter, Couch, Fergus, Chenevix‐Trench, Georgia, Pharoah, Paul DP, Garcia‐Closas, Montserrat, Schmidt, Marjanka K, Hall, Per, Easton, Douglas F, and Chang‐Claude, Jenny

Subjects
Biological Sciences, Genetics, Epidemiology, Health Services and Systems, Health Sciences, Genetic Testing, Human Genome, Prevention, Breast Cancer, Aging, Clinical Research, Cancer, Aetiology, 2.1 Biological and endogenous factors, Adolescent, Body Height, Body Mass Index, Breast Neoplasms, Chromosomes, Human, Pair 21, Chromosomes, Human, Pair 6, Female, Gene-Environment Interaction, Genetic Loci, Genetic Predisposition to Disease, Humans, Linkage Disequilibrium, Menarche, Middle Aged, Parity, Polymorphism, Single Nucleotide, Postmenopause, White People, breast cancer risk, gene-environment interaction, polymorphisms, body mass index, case-control study, Public Health and Health Services
Abstract

Genes that alter disease risk only in combination with certain environmental exposures may not be detected in genetic association analysis. By using methods accounting for gene-environment (G × E) interaction, we aimed to identify novel genetic loci associated with breast cancer risk. Up to 34,475 cases and 34,786 controls of European ancestry from up to 23 studies in the Breast Cancer Association Consortium were included. Overall, 71,527 single nucleotide polymorphisms (SNPs), enriched for association with breast cancer, were tested for interaction with 10 environmental risk factors using three recently proposed hybrid methods and a joint test of association and interaction. Analyses were adjusted for age, study, population stratification, and confounding factors as applicable. Three SNPs in two independent loci showed statistically significant association: SNPs rs10483028 and rs2242714 in perfect linkage disequilibrium on chromosome 21 and rs12197388 in ARID1B on chromosome 6. While rs12197388 was identified using the joint test with parity and with age at menarche (P-values = 3 × 10(-07)), the variants on chromosome 21 q22.12, which showed interaction with adult body mass index (BMI) in 8,891 postmenopausal women, were identified by all methods applied. SNP rs10483028 was associated with breast cancer in women with a BMI below 25 kg/m(2) (OR = 1.26, 95% CI 1.15-1.38) but not in women with a BMI of 30 kg/m(2) or higher (OR = 0.89, 95% CI 0.72-1.11, P for interaction = 3.2 × 10(-05)). Our findings confirm comparable power of the recent methods for detecting G × E interaction and the utility of using G × E interaction analyses to identify new susceptibility loci.

Published
2014

25. Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1.

Author

Meyer, Kerstin B, O'Reilly, Martin, Michailidou, Kyriaki, Carlebur, Saskia, Edwards, Stacey L, French, Juliet D, Prathalingham, Radhika, Dennis, Joe, Bolla, Manjeet K, Wang, Qin, de Santiago, Ines, Hopper, John L, Tsimiklis, Helen, Apicella, Carmel, Southey, Melissa C, Schmidt, Marjanka K, Broeks, Annegien, Van 't Veer, Laura J, Hogervorst, Frans B, Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Fasching, Peter A, Lux, Michael P, Ekici, Arif B, Beckmann, Matthias W, Peto, Julian, Dos Santos Silva, Isabel, Fletcher, Olivia, Johnson, Nichola, Sawyer, Elinor J, Tomlinson, Ian, Kerin, Michael J, Miller, Nicola, Marme, Federick, Schneeweiss, Andreas, Sohn, Christof, Burwinkel, Barbara, Guénel, Pascal, Truong, Thérèse, Laurent-Puig, Pierre, Menegaux, Florence, Bojesen, Stig E, Nordestgaard, Børge G, Nielsen, Sune F, Flyger, Henrik, Milne, Roger L, Zamora, M Pilar, Arias, Jose I, Benitez, Javier, Neuhausen, Susan, Anton-Culver, Hoda, Ziogas, Argyrios, Dur, Christina C, Brenner, Hermann, Müller, Heiko, Arndt, Volker, Stegmaier, Christa, Meindl, Alfons, Schmutzler, Rita K, Engel, Christoph, Ditsch, Nina, Brauch, Hiltrud, Brüning, Thomas, Ko, Yon-Dschun, GENICA Network, Nevanlinna, Heli, Muranen, Taru A, Aittomäki, Kristiina, Blomqvist, Carl, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Yatabe, Yasushi, Dörk, Thilo, Helbig, Sonja, Bogdanova, Natalia V, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M, Chenevix-Trench, Georgia, kConFab Investigators, Australian Ovarian Cancer Study Group, Wu, Anna H, Tseng, Chiu-Chen, Van Den Berg, David, Stram, Daniel O, Lambrechts, Diether, Thienpont, Bernard, Christiaens, Marie-Rose, Smeets, Ann, Chang-Claude, Jenny, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, and Radice, Paolo

Subjects
GENICA Network, kConFab Investigators, Australian Ovarian Cancer Study Group, Cell Line, Tumor, Humans, Breast Neoplasms, Case-Control Studies, Chromatin Immunoprecipitation, Chromosome Mapping, Gene Expression Regulation, Neoplastic, RNA Interference, Binding Sites, Protein Binding, Haplotypes, Alleles, Female, E2F1 Transcription Factor, Receptor, Fibroblast Growth Factor, Type 2, Hepatocyte Nuclear Factor 3-alpha, Promoter Regions, Genetic, Genetic Loci, Position-Specific Scoring Matrices, Genetic Association Studies, Asian People, White People, Black People, Cancer, Human Genome, Breast Cancer, Genetics, Prevention, 2.1 Biological and endogenous factors, Aetiology, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

The 10q26 locus in the second intron of FGFR2 is the locus most strongly associated with estrogen-receptor-positive breast cancer in genome-wide association studies. We conducted fine-scale mapping in case-control studies genotyped with a custom chip (iCOGS), comprising 41 studies (n = 89,050) of European ancestry, 9 Asian ancestry studies (n = 13,983), and 2 African ancestry studies (n = 2,028) from the Breast Cancer Association Consortium. We identified three statistically independent risk signals within the locus. Within risk signals 1 and 3, genetic analysis identified five and two variants, respectively, highly correlated with the most strongly associated SNPs. By using a combination of genetic fine mapping, data on DNase hypersensitivity, and electrophoretic mobility shift assays to study protein-DNA binding, we identified rs35054928, rs2981578, and rs45631563 as putative functional SNPs. Chromatin immunoprecipitation showed that FOXA1 preferentially bound to the risk-associated allele (C) of rs2981578 and was able to recruit ERα to this site in an allele-specific manner, whereas E2F1 preferentially bound the risk variant of rs35054928. The risk alleles were preferentially found in open chromatin and bound by Ser5 phosphorylated RNA polymerase II, suggesting that the risk alleles are associated with changes in transcription. Chromatin conformation capture demonstrated that the risk region was able to interact with the promoter of FGFR2, the likely target gene of this risk region. A role for FOXA1 in mediating breast cancer susceptibility at this locus is consistent with the finding that the FGFR2 risk locus primarily predisposes to estrogen-receptor-positive disease.

Published
2013

26. Evidence of Gene�Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors

Author

Nickels, Stefan, Truong, Thérèse, Hein, Rebecca, Stevens, Kristen, Buck, Katharina, Behrens, Sabine, Eilber, Ursula, Schmidt, Martina, Häberle, Lothar, Vrieling, Alina, Gaudet, Mia, Figueroa, Jonine, Schoof, Nils, Spurdle, Amanda B, Rudolph, Anja, Fasching, Peter A, Hopper, John L, Makalic, Enes, Schmidt, Daniel F, Southey, Melissa C, Beckmann, Matthias W, Ekici, Arif B, Fletcher, Olivia, Gibson, Lorna, dos Santos Silva, Isabel, Peto, Julian, Humphreys, Manjeet K, Wang, Jean, Cordina-Duverger, Emilie, Menegaux, Florence, Nordestgaard, Børge G, Bojesen, Stig E, Lanng, Charlotte, Anton-Culver, Hoda, Ziogas, Argyrios, Bernstein, Leslie, Clarke, Christina A, Brenner, Hermann, Müller, Heiko, Arndt, Volker, Stegmaier, Christa, Brauch, Hiltrud, Brüning, Thomas, Harth, Volker, GENICA Network, The, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M, kConFab, The, Group, AOCS Management, Lambrechts, Diether, Smeets, Dominiek, Neven, Patrick, Paridaens, Robert, Flesch-Janys, Dieter, Obi, Nadia, Wang-Gohrke, Shan, Couch, Fergus J, Olson, Janet E, Vachon, Celine M, Giles, Graham G, Severi, Gianluca, Baglietto, Laura, Offit, Kenneth, John, Esther M, Miron, Alexander, Andrulis, Irene L, Knight, Julia A, Glendon, Gord, Mulligan, Anna Marie, Chanock, Stephen J, Lissowska, Jolanta, Liu, Jianjun, Cox, Angela, Cramp, Helen, Connley, Dan, Balasubramanian, Sabapathy, Dunning, Alison M, Shah, Mitul, Trentham-Dietz, Amy, Newcomb, Polly, Titus, Linda, Egan, Kathleen, Cahoon, Elizabeth K, Rajaraman, Preetha, Sigurdson, Alice J, Doody, Michele M, Guénel, Pascal, Pharoah, Paul D. P, Schmidt, Marjanka K, Hall, Per, Easton, Doug F, Garcia-Closas, Montserrat, Milne, Roger L, Chang-Claude, Jenny, and Horwitz, Marshall S

Subjects
Genome-Wide Association, Mammographic Density, 14q24.1 Rad51l1, Hormone-Therapy, Pooled Analysis, Tumor Subtypes, Variants, Consortium, Fgfr2, Women
Published
2013

27. 9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium

Author

Warren, Helen, Dudbridge, Frank, Fletcher, Olivia, Orr, Nick, Johnson, Nichola, Hopper, John L, Apicella, Carmel, Southey, Melissa C, Mahmoodi, Maryam, Schmidt, Marjanka K, Broeks, Annegien, Cornelissen, Sten, Braaf, Linda M, Muir, Kenneth R, Lophatananon, Artitaya, Chaiwerawattana, Arkom, Wiangnon, Surapon, Fasching, Peter A, Beckmann, Matthias W, Ekici, Arif B, Schulz-Wendtland, Ruediger, Sawyer, Elinor J, Tomlinson, Ian, Kerin, Michael, Burwinkel, Barbara, Marme, Frederik, Schneeweiss, Andreas, Sohn, Christof, Guénel, Pascal, Truong, Thérèse, Laurent-Puig, Pierre, Mulot, Claire, Bojesen, Stig E, Nielsen, Sune F, Flyger, Henrik, Nordestgaard, Børge G, Milne, Roger L, Benítez, Javier, Arias-Pérez, José-Ignacio, Zamora, M Pilar, Anton-Culver, Hoda, Ziogas, Argyrios, Bernstein, Leslie, Dur, Christina Clarke, Brenner, Hermann, Müller, Heiko, Arndt, Volker, Langheinz, Anne, Meindl, Alfons, Golatta, Michael, Bartram, Claus R, Schmutzler, Rita K, Brauch, Hiltrud, Justenhoven, Christina, Brüning, Thomas, Network, for The GENICA, Chang-Claude, Jenny, Wang-Gohrke, Shan, Eilber, Ursula, Dörk, Thilo, Schürmann, Peter, Bremer, Michael, Hillemanns, Peter, Nevanlinna, Heli, Muranen, Taru A, Aittomäki, Kristiina, Blomqvist, Carl, Bogdanova, Natalia, Antonenkova, Natalia, Rogov, Yuriy, Bermisheva, Marina, Prokofyeva, Darya, Zinnatullina, Guzel, Khusnutdinova, Elza, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kosma, Veli-Matti, Hartikainen, Jaana M, Kataja, Vesa, Chenevix-Trench, Georgia, Beesley, Jonathan, Chen, Xiaoqing, Investigators, for kConFab, Group, Australian Ovarian Cancer Study, Lambrechts, Diether, Smeets, Ann, Paridaens, Robert, Weltens, Caroline, Flesch-Janys, Dieter, Buck, Katharina, Behrens, Sabine, Peterlongo, Paolo, Bernard, Loris, Manoukian, Siranoush, Radice, Paolo, Couch, Fergus J, Vachon, Celine, Wang, Xianshu, and Olson, Janet

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Oncology and Carcinogenesis, Genetics, Human Genome, Aging, Breast Cancer, Clinical Research, Cancer, 2.1 Biological and endogenous factors, Aetiology, Aged, Breast Neoplasms, Case-Control Studies, Chromosome Mapping, Chromosomes, Human, Pair 9, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Middle Aged, Polymorphism, Single Nucleotide, Receptors, Estrogen, Receptors, Progesterone, GENICA Network, kConFab Investigators, Australian Ovarian Cancer Study Group, Medical and Health Sciences, Epidemiology, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundOur recent genome-wide association study identified a novel breast cancer susceptibility locus at 9q31.2 (rs865686).MethodsTo further investigate the rs865686-breast cancer association, we conducted a replication study within the Breast Cancer Association Consortium, which comprises 37 case-control studies (48,394 cases, 50,836 controls).ResultsThis replication study provides additional strong evidence of an inverse association between rs865686 and breast cancer risk [study-adjusted per G-allele OR, 0.90; 95% confidence interval (CI), 0.88; 0.91, P = 2.01 × 10(-29)] among women of European ancestry. There were ethnic differences in the estimated minor (G)-allele frequency among controls [0.09, 0.30, and 0.38 among, respectively, Asians, Eastern Europeans, and other Europeans; P for heterogeneity (P(het)) = 1.3 × 10(-143)], but no evidence of ethnic differences in per allele OR (P(het) = 0.43). rs865686 was associated with estrogen receptor-positive (ER(+)) disease (per G-allele OR, 0.89; 95% CI, 0.86-0.91; P = 3.13 × 10(-22)) but less strongly, if at all, with ER-negative (ER(-)) disease (OR, 0.98; 95% CI, 0.94-1.02; P = 0.26; P(het) = 1.16 × 10(-6)), with no evidence of independent heterogeneity by progesterone receptor or HER2 status. The strength of the breast cancer association decreased with increasing age at diagnosis, with case-only analysis showing a trend in the number of copies of the G allele with increasing age at diagnosis (P for linear trend = 0.0095), but only among women with ER(+) tumors.ConclusionsThis study is the first to show that rs865686 is a susceptibility marker for ER(+) breast cancer.ImpactThe findings further support the view that genetic susceptibility varies according to tumor subtype.

Published
2012

29. Data from 9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium

Author

Warren, Helen, primary, Dudbridge, Frank, primary, Fletcher, Olivia, primary, Orr, Nick, primary, Johnson, Nichola, primary, Hopper, John L., primary, Apicella, Carmel, primary, Southey, Melissa C., primary, Mahmoodi, Maryam, primary, Schmidt, Marjanka K., primary, Broeks, Annegien, primary, Cornelissen, Sten, primary, Braaf, Linda M., primary, Muir, Kenneth R., primary, Lophatananon, Artitaya, primary, Chaiwerawattana, Arkom, primary, Wiangnon, Surapon, primary, Fasching, Peter A., primary, Beckmann, Matthias W., primary, Ekici, Arif B., primary, Schulz-Wendtland, Ruediger, primary, Sawyer, Elinor J., primary, Tomlinson, Ian, primary, Kerin, Michael, primary, Burwinkel, Barbara, primary, Marme, Frederik, primary, Schneeweiss, Andreas, primary, Sohn, Christof, primary, Guénel, Pascal, primary, Truong, Thérèse, primary, Laurent-Puig, Pierre, primary, Mulot, Claire, primary, Bojesen, Stig E, primary, Nielsen, Sune F., primary, Flyger, Henrik, primary, Nordestgaard, Børge G, primary, Milne, Roger L., primary, Benítez, Javier, primary, Arias-Pérez, José-Ignacio, primary, Zamora, M. Pilar, primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Bernstein, Leslie, primary, Dur, Christina Clarke, primary, Brenner, Hermann, primary, Müller, Heiko, primary, Arndt, Volker, primary, Langheinz, Anne, primary, Meindl, Alfons, primary, Golatta, Michael, primary, Bartram, Claus R., primary, Schmutzler, Rita K., primary, Brauch, Hiltrud, primary, Justenhoven, Christina, primary, Brüning, Thomas, primary, Chang-Claude, Jenny, primary, Wang-Gohrke, Shan, primary, Eilber, Ursula, primary, Dörk, Thilo, primary, Schürmann, Peter, primary, Bremer, Michael, primary, Hillemanns, Peter, primary, Nevanlinna, Heli, primary, Muranen, Taru A., primary, Aittomäki, Kristiina, primary, Blomqvist, Carl, primary, Bogdanova, Natalia, primary, Antonenkova, Natalia, primary, Rogov, Yuriy, primary, Bermisheva, Marina, primary, Prokofyeva, Darya, primary, Zinnatullina, Guzel, primary, Khusnutdinova, Elza, primary, Lindblom, Annika, primary, Margolin, Sara, primary, Mannermaa, Arto, primary, Kosma, Veli-Matti, primary, Hartikainen, Jaana M., primary, Kataja, Vesa, primary, Chenevix-Trench, Georgia, primary, Beesley, Jonathan, primary, Chen, Xiaoqing, primary, Lambrechts, Diether, primary, Smeets, Ann, primary, Paridaens, Robert, primary, Weltens, Caroline, primary, Flesch-Janys, Dieter, primary, Buck, Katharina, primary, Behrens, Sabine, primary, Peterlongo, Paolo, primary, Bernard, Loris, primary, Manoukian, Siranoush, primary, Radice, Paolo, primary, Couch, Fergus J., primary, Vachon, Celine, primary, Wang, Xianshu, primary, Olson, Janet, primary, Giles, Graham, primary, Baglietto, Laura, primary, McLean, Cariona A., primary, Severi, Gianluca, primary, John, Esther M., primary, Miron, Alexander, primary, Winqvist, Robert, primary, Pylkäs, Katri, primary, Jukkola-Vuorinen, Arja, primary, Grip, Mervi, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Mulligan, Anna Marie, primary, Weerasooriya, Nayana, primary, Devilee, Peter, primary, Tollenaar, Robert A.E.M., primary, Martens, John W.M., primary, Seynaeve, Caroline M., primary, Hooning, Maartje J., primary, Hollestelle, Antoinette, primary, Jager, Agnes, primary, Tilanus-Linthorst, Madeleine M.A., primary, Hall, Per, primary, Czene, Kamila, primary, Liu, Jianjun, primary, Li, Jingmei, primary, Cox, Angela, primary, Cross, Simon S., primary, Brock, Ian W., primary, Reed, Malcolm W.R., primary, Pharoah, Paul, primary, Blows, Fiona M., primary, Dunning, Alison M., primary, Ghoussaini, Maya, primary, Ashworth, Alan, primary, Swerdlow, Anthony, primary, Jones, Michael, primary, Schoemaker, Minouk, primary, Easton, Douglas F., primary, Humphreys, Manjeet, primary, Wang, Qin, primary, Peto, Julian, primary, and dos-Santos-Silva, Isabel, primary

Published
2023
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30. Supplementary Table 3 from 9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium

Author

Warren, Helen, primary, Dudbridge, Frank, primary, Fletcher, Olivia, primary, Orr, Nick, primary, Johnson, Nichola, primary, Hopper, John L., primary, Apicella, Carmel, primary, Southey, Melissa C., primary, Mahmoodi, Maryam, primary, Schmidt, Marjanka K., primary, Broeks, Annegien, primary, Cornelissen, Sten, primary, Braaf, Linda M., primary, Muir, Kenneth R., primary, Lophatananon, Artitaya, primary, Chaiwerawattana, Arkom, primary, Wiangnon, Surapon, primary, Fasching, Peter A., primary, Beckmann, Matthias W., primary, Ekici, Arif B., primary, Schulz-Wendtland, Ruediger, primary, Sawyer, Elinor J., primary, Tomlinson, Ian, primary, Kerin, Michael, primary, Burwinkel, Barbara, primary, Marme, Frederik, primary, Schneeweiss, Andreas, primary, Sohn, Christof, primary, Guénel, Pascal, primary, Truong, Thérèse, primary, Laurent-Puig, Pierre, primary, Mulot, Claire, primary, Bojesen, Stig E, primary, Nielsen, Sune F., primary, Flyger, Henrik, primary, Nordestgaard, Børge G, primary, Milne, Roger L., primary, Benítez, Javier, primary, Arias-Pérez, José-Ignacio, primary, Zamora, M. Pilar, primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Bernstein, Leslie, primary, Dur, Christina Clarke, primary, Brenner, Hermann, primary, Müller, Heiko, primary, Arndt, Volker, primary, Langheinz, Anne, primary, Meindl, Alfons, primary, Golatta, Michael, primary, Bartram, Claus R., primary, Schmutzler, Rita K., primary, Brauch, Hiltrud, primary, Justenhoven, Christina, primary, Brüning, Thomas, primary, Chang-Claude, Jenny, primary, Wang-Gohrke, Shan, primary, Eilber, Ursula, primary, Dörk, Thilo, primary, Schürmann, Peter, primary, Bremer, Michael, primary, Hillemanns, Peter, primary, Nevanlinna, Heli, primary, Muranen, Taru A., primary, Aittomäki, Kristiina, primary, Blomqvist, Carl, primary, Bogdanova, Natalia, primary, Antonenkova, Natalia, primary, Rogov, Yuriy, primary, Bermisheva, Marina, primary, Prokofyeva, Darya, primary, Zinnatullina, Guzel, primary, Khusnutdinova, Elza, primary, Lindblom, Annika, primary, Margolin, Sara, primary, Mannermaa, Arto, primary, Kosma, Veli-Matti, primary, Hartikainen, Jaana M., primary, Kataja, Vesa, primary, Chenevix-Trench, Georgia, primary, Beesley, Jonathan, primary, Chen, Xiaoqing, primary, Lambrechts, Diether, primary, Smeets, Ann, primary, Paridaens, Robert, primary, Weltens, Caroline, primary, Flesch-Janys, Dieter, primary, Buck, Katharina, primary, Behrens, Sabine, primary, Peterlongo, Paolo, primary, Bernard, Loris, primary, Manoukian, Siranoush, primary, Radice, Paolo, primary, Couch, Fergus J., primary, Vachon, Celine, primary, Wang, Xianshu, primary, Olson, Janet, primary, Giles, Graham, primary, Baglietto, Laura, primary, McLean, Cariona A., primary, Severi, Gianluca, primary, John, Esther M., primary, Miron, Alexander, primary, Winqvist, Robert, primary, Pylkäs, Katri, primary, Jukkola-Vuorinen, Arja, primary, Grip, Mervi, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Mulligan, Anna Marie, primary, Weerasooriya, Nayana, primary, Devilee, Peter, primary, Tollenaar, Robert A.E.M., primary, Martens, John W.M., primary, Seynaeve, Caroline M., primary, Hooning, Maartje J., primary, Hollestelle, Antoinette, primary, Jager, Agnes, primary, Tilanus-Linthorst, Madeleine M.A., primary, Hall, Per, primary, Czene, Kamila, primary, Liu, Jianjun, primary, Li, Jingmei, primary, Cox, Angela, primary, Cross, Simon S., primary, Brock, Ian W., primary, Reed, Malcolm W.R., primary, Pharoah, Paul, primary, Blows, Fiona M., primary, Dunning, Alison M., primary, Ghoussaini, Maya, primary, Ashworth, Alan, primary, Swerdlow, Anthony, primary, Jones, Michael, primary, Schoemaker, Minouk, primary, Easton, Douglas F., primary, Humphreys, Manjeet, primary, Wang, Qin, primary, Peto, Julian, primary, and dos-Santos-Silva, Isabel, primary

Published
2023
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31. Data from Confirmation of 5p12 As a Susceptibility Locus for Progesterone-Receptor–Positive, Lower Grade Breast Cancer

Author

Milne, Roger L., primary, Goode, Ellen L., primary, García-Closas, Montserrat, primary, Couch, Fergus J., primary, Severi, Gianluca, primary, Hein, Rebecca, primary, Fredericksen, Zachary, primary, Malats, Núria, primary, Zamora, M. Pilar, primary, Pérez, Jose Ignacio Arias, primary, Benítez, Javier, primary, Dörk, Thilo, primary, Schürmann, Peter, primary, Karstens, Johann H., primary, Hillemanns, Peter, primary, Cox, Angela, primary, Brock, Ian W., primary, Elliot, Graeme, primary, Cross, Simon S., primary, Seal, Sheila, primary, Turnbull, Clare, primary, Renwick, Anthony, primary, Rahman, Nazneen, primary, Shen, Chen-Yang, primary, Yu, Jyh-Cherng, primary, Huang, Chiun-Sheng, primary, Hou, Ming-Feng, primary, Nordestgaard, Børge G., primary, Bojesen, Stig E., primary, Lanng, Charlotte, primary, Alnæs, Grethe Grenaker, primary, Kristensen, Vessela, primary, Børrensen-Dale, Anne-Lise, primary, Hopper, John L., primary, Dite, Gillian S., primary, Apicella, Carmel, primary, Southey, Melissa C., primary, Lambrechts, Diether, primary, Yesilyurt, Betül T., primary, Floris, Giuseppe, primary, Leunen, Karin, primary, Sangrajrang, Suleeporn, primary, Gaborieau, Valerie, primary, Brennan, Paul, primary, McKay, James, primary, Chang-Claude, Jenny, primary, Wang-Gohrke, Shan, primary, Radice, Paolo, primary, Peterlongo, Paolo, primary, Manoukian, Siranoush, primary, Barile, Monica, primary, Giles, Graham G., primary, Baglietto, Laura, primary, John, Esther M., primary, Miron, Alexander, primary, Chanock, Stephen J., primary, Lissowska, Jolanta, primary, Sherman, Mark E., primary, Figueroa, Jonine D., primary, Bogdanova, Natalia V., primary, Antonenkova, Natalia N., primary, Zalutsky, Iosif V., primary, Rogov, Yuri I., primary, Fasching, Peter A., primary, Bayer, Christian M., primary, Ekici, Arif B., primary, Beckmann, Matthias W., primary, Brenner, Hermann, primary, Müller, Heiko, primary, Arndt, Volker, primary, Stegmaier, Christa, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Glendon, Gord, primary, Mulligan, Anna Marie, primary, Mannermaa, Arto, primary, Kataja, Vesa, primary, Kosma, Veli-Matti, primary, Hartikainen, Jaana M., primary, Meindl, Alfons, primary, Heil, Joerg, primary, Bartram, Claus R., primary, Schmutzler, Rita K., primary, Thomas, Gilles D., primary, Hoover, Robert N., primary, Fletcher, Olivia, primary, Gibson, Lorna J., primary, dos Santos Silva, Isabel, primary, Peto, Julian, primary, Nickels, Stefan, primary, Flesch-Janys, Dieter, primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Sawyer, Elinor, primary, Tomlinson, Ian, primary, Kerin, Michael, primary, Miller, Nicola, primary, Schmidt, Marjanka K., primary, Broeks, Annegien, primary, Van ‘t Veer, Laura J., primary, Tollenaar, Rob A.E.M., primary, Pharoah, Paul D.P., primary, Dunning, Alison M., primary, Pooley, Karen A., primary, Marme, Frederik, primary, Schneeweiss, Andreas, primary, Sohn, Christof, primary, Burwinkel, Barbara, primary, Jakubowska, Anna, primary, Lubinski, Jan, primary, Jaworska, Katarzyna, primary, Durda, Katarzyna, primary, Kang, Daehee, primary, Yoo, Keun-Young, primary, Noh, Dong-Young, primary, Ahn, Sei-Hyun, primary, Hunter, David J., primary, Hankinson, Susan E., primary, Kraft, Peter, primary, Lindstrom, Sara, primary, Chen, Xiaoqing, primary, Beesley, Jonathan, primary, Hamann, Ute, primary, Harth, Volker, primary, Justenhoven, Christina, primary, Winqvist, Robert, primary, Pylkäs, Katri, primary, Jukkola-Vuorinen, Arja, primary, Grip, Mervi, primary, Hooning, Maartje, primary, Hollestelle, Antoinette, primary, Oldenburg, Rogier A., primary, Tilanus-Linthorst, Madeleine, primary, Khusnutdinova, Elza, primary, Bermisheva, Marina, primary, Prokofieva, Darya, primary, Farahtdinova, Albina, primary, Olson, Janet E., primary, Wang, Xianshu, primary, Humphreys, Manjeet K., primary, Wang, Qin, primary, Chenevix-Trench, Georgia, primary, and Easton, Douglas F., primary

Published
2023
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32. Supplementary Table 3 from Confirmation of 5p12 As a Susceptibility Locus for Progesterone-Receptor–Positive, Lower Grade Breast Cancer

Author

Milne, Roger L., primary, Goode, Ellen L., primary, García-Closas, Montserrat, primary, Couch, Fergus J., primary, Severi, Gianluca, primary, Hein, Rebecca, primary, Fredericksen, Zachary, primary, Malats, Núria, primary, Zamora, M. Pilar, primary, Pérez, Jose Ignacio Arias, primary, Benítez, Javier, primary, Dörk, Thilo, primary, Schürmann, Peter, primary, Karstens, Johann H., primary, Hillemanns, Peter, primary, Cox, Angela, primary, Brock, Ian W., primary, Elliot, Graeme, primary, Cross, Simon S., primary, Seal, Sheila, primary, Turnbull, Clare, primary, Renwick, Anthony, primary, Rahman, Nazneen, primary, Shen, Chen-Yang, primary, Yu, Jyh-Cherng, primary, Huang, Chiun-Sheng, primary, Hou, Ming-Feng, primary, Nordestgaard, Børge G., primary, Bojesen, Stig E., primary, Lanng, Charlotte, primary, Alnæs, Grethe Grenaker, primary, Kristensen, Vessela, primary, Børrensen-Dale, Anne-Lise, primary, Hopper, John L., primary, Dite, Gillian S., primary, Apicella, Carmel, primary, Southey, Melissa C., primary, Lambrechts, Diether, primary, Yesilyurt, Betül T., primary, Floris, Giuseppe, primary, Leunen, Karin, primary, Sangrajrang, Suleeporn, primary, Gaborieau, Valerie, primary, Brennan, Paul, primary, McKay, James, primary, Chang-Claude, Jenny, primary, Wang-Gohrke, Shan, primary, Radice, Paolo, primary, Peterlongo, Paolo, primary, Manoukian, Siranoush, primary, Barile, Monica, primary, Giles, Graham G., primary, Baglietto, Laura, primary, John, Esther M., primary, Miron, Alexander, primary, Chanock, Stephen J., primary, Lissowska, Jolanta, primary, Sherman, Mark E., primary, Figueroa, Jonine D., primary, Bogdanova, Natalia V., primary, Antonenkova, Natalia N., primary, Zalutsky, Iosif V., primary, Rogov, Yuri I., primary, Fasching, Peter A., primary, Bayer, Christian M., primary, Ekici, Arif B., primary, Beckmann, Matthias W., primary, Brenner, Hermann, primary, Müller, Heiko, primary, Arndt, Volker, primary, Stegmaier, Christa, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Glendon, Gord, primary, Mulligan, Anna Marie, primary, Mannermaa, Arto, primary, Kataja, Vesa, primary, Kosma, Veli-Matti, primary, Hartikainen, Jaana M., primary, Meindl, Alfons, primary, Heil, Joerg, primary, Bartram, Claus R., primary, Schmutzler, Rita K., primary, Thomas, Gilles D., primary, Hoover, Robert N., primary, Fletcher, Olivia, primary, Gibson, Lorna J., primary, dos Santos Silva, Isabel, primary, Peto, Julian, primary, Nickels, Stefan, primary, Flesch-Janys, Dieter, primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Sawyer, Elinor, primary, Tomlinson, Ian, primary, Kerin, Michael, primary, Miller, Nicola, primary, Schmidt, Marjanka K., primary, Broeks, Annegien, primary, Van ‘t Veer, Laura J., primary, Tollenaar, Rob A.E.M., primary, Pharoah, Paul D.P., primary, Dunning, Alison M., primary, Pooley, Karen A., primary, Marme, Frederik, primary, Schneeweiss, Andreas, primary, Sohn, Christof, primary, Burwinkel, Barbara, primary, Jakubowska, Anna, primary, Lubinski, Jan, primary, Jaworska, Katarzyna, primary, Durda, Katarzyna, primary, Kang, Daehee, primary, Yoo, Keun-Young, primary, Noh, Dong-Young, primary, Ahn, Sei-Hyun, primary, Hunter, David J., primary, Hankinson, Susan E., primary, Kraft, Peter, primary, Lindstrom, Sara, primary, Chen, Xiaoqing, primary, Beesley, Jonathan, primary, Hamann, Ute, primary, Harth, Volker, primary, Justenhoven, Christina, primary, Winqvist, Robert, primary, Pylkäs, Katri, primary, Jukkola-Vuorinen, Arja, primary, Grip, Mervi, primary, Hooning, Maartje, primary, Hollestelle, Antoinette, primary, Oldenburg, Rogier A., primary, Tilanus-Linthorst, Madeleine, primary, Khusnutdinova, Elza, primary, Bermisheva, Marina, primary, Prokofieva, Darya, primary, Farahtdinova, Albina, primary, Olson, Janet E., primary, Wang, Xianshu, primary, Humphreys, Manjeet K., primary, Wang, Qin, primary, Chenevix-Trench, Georgia, primary, and Easton, Douglas F., primary

Published
2023
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33. Supplementary Table 2 from 9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium

Author

Warren, Helen, primary, Dudbridge, Frank, primary, Fletcher, Olivia, primary, Orr, Nick, primary, Johnson, Nichola, primary, Hopper, John L., primary, Apicella, Carmel, primary, Southey, Melissa C., primary, Mahmoodi, Maryam, primary, Schmidt, Marjanka K., primary, Broeks, Annegien, primary, Cornelissen, Sten, primary, Braaf, Linda M., primary, Muir, Kenneth R., primary, Lophatananon, Artitaya, primary, Chaiwerawattana, Arkom, primary, Wiangnon, Surapon, primary, Fasching, Peter A., primary, Beckmann, Matthias W., primary, Ekici, Arif B., primary, Schulz-Wendtland, Ruediger, primary, Sawyer, Elinor J., primary, Tomlinson, Ian, primary, Kerin, Michael, primary, Burwinkel, Barbara, primary, Marme, Frederik, primary, Schneeweiss, Andreas, primary, Sohn, Christof, primary, Guénel, Pascal, primary, Truong, Thérèse, primary, Laurent-Puig, Pierre, primary, Mulot, Claire, primary, Bojesen, Stig E, primary, Nielsen, Sune F., primary, Flyger, Henrik, primary, Nordestgaard, Børge G, primary, Milne, Roger L., primary, Benítez, Javier, primary, Arias-Pérez, José-Ignacio, primary, Zamora, M. Pilar, primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Bernstein, Leslie, primary, Dur, Christina Clarke, primary, Brenner, Hermann, primary, Müller, Heiko, primary, Arndt, Volker, primary, Langheinz, Anne, primary, Meindl, Alfons, primary, Golatta, Michael, primary, Bartram, Claus R., primary, Schmutzler, Rita K., primary, Brauch, Hiltrud, primary, Justenhoven, Christina, primary, Brüning, Thomas, primary, Chang-Claude, Jenny, primary, Wang-Gohrke, Shan, primary, Eilber, Ursula, primary, Dörk, Thilo, primary, Schürmann, Peter, primary, Bremer, Michael, primary, Hillemanns, Peter, primary, Nevanlinna, Heli, primary, Muranen, Taru A., primary, Aittomäki, Kristiina, primary, Blomqvist, Carl, primary, Bogdanova, Natalia, primary, Antonenkova, Natalia, primary, Rogov, Yuriy, primary, Bermisheva, Marina, primary, Prokofyeva, Darya, primary, Zinnatullina, Guzel, primary, Khusnutdinova, Elza, primary, Lindblom, Annika, primary, Margolin, Sara, primary, Mannermaa, Arto, primary, Kosma, Veli-Matti, primary, Hartikainen, Jaana M., primary, Kataja, Vesa, primary, Chenevix-Trench, Georgia, primary, Beesley, Jonathan, primary, Chen, Xiaoqing, primary, Lambrechts, Diether, primary, Smeets, Ann, primary, Paridaens, Robert, primary, Weltens, Caroline, primary, Flesch-Janys, Dieter, primary, Buck, Katharina, primary, Behrens, Sabine, primary, Peterlongo, Paolo, primary, Bernard, Loris, primary, Manoukian, Siranoush, primary, Radice, Paolo, primary, Couch, Fergus J., primary, Vachon, Celine, primary, Wang, Xianshu, primary, Olson, Janet, primary, Giles, Graham, primary, Baglietto, Laura, primary, McLean, Cariona A., primary, Severi, Gianluca, primary, John, Esther M., primary, Miron, Alexander, primary, Winqvist, Robert, primary, Pylkäs, Katri, primary, Jukkola-Vuorinen, Arja, primary, Grip, Mervi, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Mulligan, Anna Marie, primary, Weerasooriya, Nayana, primary, Devilee, Peter, primary, Tollenaar, Robert A.E.M., primary, Martens, John W.M., primary, Seynaeve, Caroline M., primary, Hooning, Maartje J., primary, Hollestelle, Antoinette, primary, Jager, Agnes, primary, Tilanus-Linthorst, Madeleine M.A., primary, Hall, Per, primary, Czene, Kamila, primary, Liu, Jianjun, primary, Li, Jingmei, primary, Cox, Angela, primary, Cross, Simon S., primary, Brock, Ian W., primary, Reed, Malcolm W.R., primary, Pharoah, Paul, primary, Blows, Fiona M., primary, Dunning, Alison M., primary, Ghoussaini, Maya, primary, Ashworth, Alan, primary, Swerdlow, Anthony, primary, Jones, Michael, primary, Schoemaker, Minouk, primary, Easton, Douglas F., primary, Humphreys, Manjeet, primary, Wang, Qin, primary, Peto, Julian, primary, and dos-Santos-Silva, Isabel, primary

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2023
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34. Supplementary Table Legend from 9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium

Author

Warren, Helen, primary, Dudbridge, Frank, primary, Fletcher, Olivia, primary, Orr, Nick, primary, Johnson, Nichola, primary, Hopper, John L., primary, Apicella, Carmel, primary, Southey, Melissa C., primary, Mahmoodi, Maryam, primary, Schmidt, Marjanka K., primary, Broeks, Annegien, primary, Cornelissen, Sten, primary, Braaf, Linda M., primary, Muir, Kenneth R., primary, Lophatananon, Artitaya, primary, Chaiwerawattana, Arkom, primary, Wiangnon, Surapon, primary, Fasching, Peter A., primary, Beckmann, Matthias W., primary, Ekici, Arif B., primary, Schulz-Wendtland, Ruediger, primary, Sawyer, Elinor J., primary, Tomlinson, Ian, primary, Kerin, Michael, primary, Burwinkel, Barbara, primary, Marme, Frederik, primary, Schneeweiss, Andreas, primary, Sohn, Christof, primary, Guénel, Pascal, primary, Truong, Thérèse, primary, Laurent-Puig, Pierre, primary, Mulot, Claire, primary, Bojesen, Stig E, primary, Nielsen, Sune F., primary, Flyger, Henrik, primary, Nordestgaard, Børge G, primary, Milne, Roger L., primary, Benítez, Javier, primary, Arias-Pérez, José-Ignacio, primary, Zamora, M. Pilar, primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Bernstein, Leslie, primary, Dur, Christina Clarke, primary, Brenner, Hermann, primary, Müller, Heiko, primary, Arndt, Volker, primary, Langheinz, Anne, primary, Meindl, Alfons, primary, Golatta, Michael, primary, Bartram, Claus R., primary, Schmutzler, Rita K., primary, Brauch, Hiltrud, primary, Justenhoven, Christina, primary, Brüning, Thomas, primary, Chang-Claude, Jenny, primary, Wang-Gohrke, Shan, primary, Eilber, Ursula, primary, Dörk, Thilo, primary, Schürmann, Peter, primary, Bremer, Michael, primary, Hillemanns, Peter, primary, Nevanlinna, Heli, primary, Muranen, Taru A., primary, Aittomäki, Kristiina, primary, Blomqvist, Carl, primary, Bogdanova, Natalia, primary, Antonenkova, Natalia, primary, Rogov, Yuriy, primary, Bermisheva, Marina, primary, Prokofyeva, Darya, primary, Zinnatullina, Guzel, primary, Khusnutdinova, Elza, primary, Lindblom, Annika, primary, Margolin, Sara, primary, Mannermaa, Arto, primary, Kosma, Veli-Matti, primary, Hartikainen, Jaana M., primary, Kataja, Vesa, primary, Chenevix-Trench, Georgia, primary, Beesley, Jonathan, primary, Chen, Xiaoqing, primary, Lambrechts, Diether, primary, Smeets, Ann, primary, Paridaens, Robert, primary, Weltens, Caroline, primary, Flesch-Janys, Dieter, primary, Buck, Katharina, primary, Behrens, Sabine, primary, Peterlongo, Paolo, primary, Bernard, Loris, primary, Manoukian, Siranoush, primary, Radice, Paolo, primary, Couch, Fergus J., primary, Vachon, Celine, primary, Wang, Xianshu, primary, Olson, Janet, primary, Giles, Graham, primary, Baglietto, Laura, primary, McLean, Cariona A., primary, Severi, Gianluca, primary, John, Esther M., primary, Miron, Alexander, primary, Winqvist, Robert, primary, Pylkäs, Katri, primary, Jukkola-Vuorinen, Arja, primary, Grip, Mervi, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Mulligan, Anna Marie, primary, Weerasooriya, Nayana, primary, Devilee, Peter, primary, Tollenaar, Robert A.E.M., primary, Martens, John W.M., primary, Seynaeve, Caroline M., primary, Hooning, Maartje J., primary, Hollestelle, Antoinette, primary, Jager, Agnes, primary, Tilanus-Linthorst, Madeleine M.A., primary, Hall, Per, primary, Czene, Kamila, primary, Liu, Jianjun, primary, Li, Jingmei, primary, Cox, Angela, primary, Cross, Simon S., primary, Brock, Ian W., primary, Reed, Malcolm W.R., primary, Pharoah, Paul, primary, Blows, Fiona M., primary, Dunning, Alison M., primary, Ghoussaini, Maya, primary, Ashworth, Alan, primary, Swerdlow, Anthony, primary, Jones, Michael, primary, Schoemaker, Minouk, primary, Easton, Douglas F., primary, Humphreys, Manjeet, primary, Wang, Qin, primary, Peto, Julian, primary, and dos-Santos-Silva, Isabel, primary

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2023
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35. Supplementary Table 1 from 9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium

Author

Warren, Helen, primary, Dudbridge, Frank, primary, Fletcher, Olivia, primary, Orr, Nick, primary, Johnson, Nichola, primary, Hopper, John L., primary, Apicella, Carmel, primary, Southey, Melissa C., primary, Mahmoodi, Maryam, primary, Schmidt, Marjanka K., primary, Broeks, Annegien, primary, Cornelissen, Sten, primary, Braaf, Linda M., primary, Muir, Kenneth R., primary, Lophatananon, Artitaya, primary, Chaiwerawattana, Arkom, primary, Wiangnon, Surapon, primary, Fasching, Peter A., primary, Beckmann, Matthias W., primary, Ekici, Arif B., primary, Schulz-Wendtland, Ruediger, primary, Sawyer, Elinor J., primary, Tomlinson, Ian, primary, Kerin, Michael, primary, Burwinkel, Barbara, primary, Marme, Frederik, primary, Schneeweiss, Andreas, primary, Sohn, Christof, primary, Guénel, Pascal, primary, Truong, Thérèse, primary, Laurent-Puig, Pierre, primary, Mulot, Claire, primary, Bojesen, Stig E, primary, Nielsen, Sune F., primary, Flyger, Henrik, primary, Nordestgaard, Børge G, primary, Milne, Roger L., primary, Benítez, Javier, primary, Arias-Pérez, José-Ignacio, primary, Zamora, M. Pilar, primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Bernstein, Leslie, primary, Dur, Christina Clarke, primary, Brenner, Hermann, primary, Müller, Heiko, primary, Arndt, Volker, primary, Langheinz, Anne, primary, Meindl, Alfons, primary, Golatta, Michael, primary, Bartram, Claus R., primary, Schmutzler, Rita K., primary, Brauch, Hiltrud, primary, Justenhoven, Christina, primary, Brüning, Thomas, primary, Chang-Claude, Jenny, primary, Wang-Gohrke, Shan, primary, Eilber, Ursula, primary, Dörk, Thilo, primary, Schürmann, Peter, primary, Bremer, Michael, primary, Hillemanns, Peter, primary, Nevanlinna, Heli, primary, Muranen, Taru A., primary, Aittomäki, Kristiina, primary, Blomqvist, Carl, primary, Bogdanova, Natalia, primary, Antonenkova, Natalia, primary, Rogov, Yuriy, primary, Bermisheva, Marina, primary, Prokofyeva, Darya, primary, Zinnatullina, Guzel, primary, Khusnutdinova, Elza, primary, Lindblom, Annika, primary, Margolin, Sara, primary, Mannermaa, Arto, primary, Kosma, Veli-Matti, primary, Hartikainen, Jaana M., primary, Kataja, Vesa, primary, Chenevix-Trench, Georgia, primary, Beesley, Jonathan, primary, Chen, Xiaoqing, primary, Lambrechts, Diether, primary, Smeets, Ann, primary, Paridaens, Robert, primary, Weltens, Caroline, primary, Flesch-Janys, Dieter, primary, Buck, Katharina, primary, Behrens, Sabine, primary, Peterlongo, Paolo, primary, Bernard, Loris, primary, Manoukian, Siranoush, primary, Radice, Paolo, primary, Couch, Fergus J., primary, Vachon, Celine, primary, Wang, Xianshu, primary, Olson, Janet, primary, Giles, Graham, primary, Baglietto, Laura, primary, McLean, Cariona A., primary, Severi, Gianluca, primary, John, Esther M., primary, Miron, Alexander, primary, Winqvist, Robert, primary, Pylkäs, Katri, primary, Jukkola-Vuorinen, Arja, primary, Grip, Mervi, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Mulligan, Anna Marie, primary, Weerasooriya, Nayana, primary, Devilee, Peter, primary, Tollenaar, Robert A.E.M., primary, Martens, John W.M., primary, Seynaeve, Caroline M., primary, Hooning, Maartje J., primary, Hollestelle, Antoinette, primary, Jager, Agnes, primary, Tilanus-Linthorst, Madeleine M.A., primary, Hall, Per, primary, Czene, Kamila, primary, Liu, Jianjun, primary, Li, Jingmei, primary, Cox, Angela, primary, Cross, Simon S., primary, Brock, Ian W., primary, Reed, Malcolm W.R., primary, Pharoah, Paul, primary, Blows, Fiona M., primary, Dunning, Alison M., primary, Ghoussaini, Maya, primary, Ashworth, Alan, primary, Swerdlow, Anthony, primary, Jones, Michael, primary, Schoemaker, Minouk, primary, Easton, Douglas F., primary, Humphreys, Manjeet, primary, Wang, Qin, primary, Peto, Julian, primary, and dos-Santos-Silva, Isabel, primary

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2023
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36. Supplementary Table 1 from Confirmation of 5p12 As a Susceptibility Locus for Progesterone-Receptor–Positive, Lower Grade Breast Cancer

Author

Milne, Roger L., primary, Goode, Ellen L., primary, García-Closas, Montserrat, primary, Couch, Fergus J., primary, Severi, Gianluca, primary, Hein, Rebecca, primary, Fredericksen, Zachary, primary, Malats, Núria, primary, Zamora, M. Pilar, primary, Pérez, Jose Ignacio Arias, primary, Benítez, Javier, primary, Dörk, Thilo, primary, Schürmann, Peter, primary, Karstens, Johann H., primary, Hillemanns, Peter, primary, Cox, Angela, primary, Brock, Ian W., primary, Elliot, Graeme, primary, Cross, Simon S., primary, Seal, Sheila, primary, Turnbull, Clare, primary, Renwick, Anthony, primary, Rahman, Nazneen, primary, Shen, Chen-Yang, primary, Yu, Jyh-Cherng, primary, Huang, Chiun-Sheng, primary, Hou, Ming-Feng, primary, Nordestgaard, Børge G., primary, Bojesen, Stig E., primary, Lanng, Charlotte, primary, Alnæs, Grethe Grenaker, primary, Kristensen, Vessela, primary, Børrensen-Dale, Anne-Lise, primary, Hopper, John L., primary, Dite, Gillian S., primary, Apicella, Carmel, primary, Southey, Melissa C., primary, Lambrechts, Diether, primary, Yesilyurt, Betül T., primary, Floris, Giuseppe, primary, Leunen, Karin, primary, Sangrajrang, Suleeporn, primary, Gaborieau, Valerie, primary, Brennan, Paul, primary, McKay, James, primary, Chang-Claude, Jenny, primary, Wang-Gohrke, Shan, primary, Radice, Paolo, primary, Peterlongo, Paolo, primary, Manoukian, Siranoush, primary, Barile, Monica, primary, Giles, Graham G., primary, Baglietto, Laura, primary, John, Esther M., primary, Miron, Alexander, primary, Chanock, Stephen J., primary, Lissowska, Jolanta, primary, Sherman, Mark E., primary, Figueroa, Jonine D., primary, Bogdanova, Natalia V., primary, Antonenkova, Natalia N., primary, Zalutsky, Iosif V., primary, Rogov, Yuri I., primary, Fasching, Peter A., primary, Bayer, Christian M., primary, Ekici, Arif B., primary, Beckmann, Matthias W., primary, Brenner, Hermann, primary, Müller, Heiko, primary, Arndt, Volker, primary, Stegmaier, Christa, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Glendon, Gord, primary, Mulligan, Anna Marie, primary, Mannermaa, Arto, primary, Kataja, Vesa, primary, Kosma, Veli-Matti, primary, Hartikainen, Jaana M., primary, Meindl, Alfons, primary, Heil, Joerg, primary, Bartram, Claus R., primary, Schmutzler, Rita K., primary, Thomas, Gilles D., primary, Hoover, Robert N., primary, Fletcher, Olivia, primary, Gibson, Lorna J., primary, dos Santos Silva, Isabel, primary, Peto, Julian, primary, Nickels, Stefan, primary, Flesch-Janys, Dieter, primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Sawyer, Elinor, primary, Tomlinson, Ian, primary, Kerin, Michael, primary, Miller, Nicola, primary, Schmidt, Marjanka K., primary, Broeks, Annegien, primary, Van ‘t Veer, Laura J., primary, Tollenaar, Rob A.E.M., primary, Pharoah, Paul D.P., primary, Dunning, Alison M., primary, Pooley, Karen A., primary, Marme, Frederik, primary, Schneeweiss, Andreas, primary, Sohn, Christof, primary, Burwinkel, Barbara, primary, Jakubowska, Anna, primary, Lubinski, Jan, primary, Jaworska, Katarzyna, primary, Durda, Katarzyna, primary, Kang, Daehee, primary, Yoo, Keun-Young, primary, Noh, Dong-Young, primary, Ahn, Sei-Hyun, primary, Hunter, David J., primary, Hankinson, Susan E., primary, Kraft, Peter, primary, Lindstrom, Sara, primary, Chen, Xiaoqing, primary, Beesley, Jonathan, primary, Hamann, Ute, primary, Harth, Volker, primary, Justenhoven, Christina, primary, Winqvist, Robert, primary, Pylkäs, Katri, primary, Jukkola-Vuorinen, Arja, primary, Grip, Mervi, primary, Hooning, Maartje, primary, Hollestelle, Antoinette, primary, Oldenburg, Rogier A., primary, Tilanus-Linthorst, Madeleine, primary, Khusnutdinova, Elza, primary, Bermisheva, Marina, primary, Prokofieva, Darya, primary, Farahtdinova, Albina, primary, Olson, Janet E., primary, Wang, Xianshu, primary, Humphreys, Manjeet K., primary, Wang, Qin, primary, Chenevix-Trench, Georgia, primary, and Easton, Douglas F., primary

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2023
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38. Supplementary Table 2 from Confirmation of 5p12 As a Susceptibility Locus for Progesterone-Receptor–Positive, Lower Grade Breast Cancer

Author

Milne, Roger L., primary, Goode, Ellen L., primary, García-Closas, Montserrat, primary, Couch, Fergus J., primary, Severi, Gianluca, primary, Hein, Rebecca, primary, Fredericksen, Zachary, primary, Malats, Núria, primary, Zamora, M. Pilar, primary, Pérez, Jose Ignacio Arias, primary, Benítez, Javier, primary, Dörk, Thilo, primary, Schürmann, Peter, primary, Karstens, Johann H., primary, Hillemanns, Peter, primary, Cox, Angela, primary, Brock, Ian W., primary, Elliot, Graeme, primary, Cross, Simon S., primary, Seal, Sheila, primary, Turnbull, Clare, primary, Renwick, Anthony, primary, Rahman, Nazneen, primary, Shen, Chen-Yang, primary, Yu, Jyh-Cherng, primary, Huang, Chiun-Sheng, primary, Hou, Ming-Feng, primary, Nordestgaard, Børge G., primary, Bojesen, Stig E., primary, Lanng, Charlotte, primary, Alnæs, Grethe Grenaker, primary, Kristensen, Vessela, primary, Børrensen-Dale, Anne-Lise, primary, Hopper, John L., primary, Dite, Gillian S., primary, Apicella, Carmel, primary, Southey, Melissa C., primary, Lambrechts, Diether, primary, Yesilyurt, Betül T., primary, Floris, Giuseppe, primary, Leunen, Karin, primary, Sangrajrang, Suleeporn, primary, Gaborieau, Valerie, primary, Brennan, Paul, primary, McKay, James, primary, Chang-Claude, Jenny, primary, Wang-Gohrke, Shan, primary, Radice, Paolo, primary, Peterlongo, Paolo, primary, Manoukian, Siranoush, primary, Barile, Monica, primary, Giles, Graham G., primary, Baglietto, Laura, primary, John, Esther M., primary, Miron, Alexander, primary, Chanock, Stephen J., primary, Lissowska, Jolanta, primary, Sherman, Mark E., primary, Figueroa, Jonine D., primary, Bogdanova, Natalia V., primary, Antonenkova, Natalia N., primary, Zalutsky, Iosif V., primary, Rogov, Yuri I., primary, Fasching, Peter A., primary, Bayer, Christian M., primary, Ekici, Arif B., primary, Beckmann, Matthias W., primary, Brenner, Hermann, primary, Müller, Heiko, primary, Arndt, Volker, primary, Stegmaier, Christa, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Glendon, Gord, primary, Mulligan, Anna Marie, primary, Mannermaa, Arto, primary, Kataja, Vesa, primary, Kosma, Veli-Matti, primary, Hartikainen, Jaana M., primary, Meindl, Alfons, primary, Heil, Joerg, primary, Bartram, Claus R., primary, Schmutzler, Rita K., primary, Thomas, Gilles D., primary, Hoover, Robert N., primary, Fletcher, Olivia, primary, Gibson, Lorna J., primary, dos Santos Silva, Isabel, primary, Peto, Julian, primary, Nickels, Stefan, primary, Flesch-Janys, Dieter, primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Sawyer, Elinor, primary, Tomlinson, Ian, primary, Kerin, Michael, primary, Miller, Nicola, primary, Schmidt, Marjanka K., primary, Broeks, Annegien, primary, Van ‘t Veer, Laura J., primary, Tollenaar, Rob A.E.M., primary, Pharoah, Paul D.P., primary, Dunning, Alison M., primary, Pooley, Karen A., primary, Marme, Frederik, primary, Schneeweiss, Andreas, primary, Sohn, Christof, primary, Burwinkel, Barbara, primary, Jakubowska, Anna, primary, Lubinski, Jan, primary, Jaworska, Katarzyna, primary, Durda, Katarzyna, primary, Kang, Daehee, primary, Yoo, Keun-Young, primary, Noh, Dong-Young, primary, Ahn, Sei-Hyun, primary, Hunter, David J., primary, Hankinson, Susan E., primary, Kraft, Peter, primary, Lindstrom, Sara, primary, Chen, Xiaoqing, primary, Beesley, Jonathan, primary, Hamann, Ute, primary, Harth, Volker, primary, Justenhoven, Christina, primary, Winqvist, Robert, primary, Pylkäs, Katri, primary, Jukkola-Vuorinen, Arja, primary, Grip, Mervi, primary, Hooning, Maartje, primary, Hollestelle, Antoinette, primary, Oldenburg, Rogier A., primary, Tilanus-Linthorst, Madeleine, primary, Khusnutdinova, Elza, primary, Bermisheva, Marina, primary, Prokofieva, Darya, primary, Farahtdinova, Albina, primary, Olson, Janet E., primary, Wang, Xianshu, primary, Humphreys, Manjeet K., primary, Wang, Qin, primary, Chenevix-Trench, Georgia, primary, and Easton, Douglas F., primary

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2023
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39. Supplementary Table 4 from Confirmation of 5p12 As a Susceptibility Locus for Progesterone-Receptor–Positive, Lower Grade Breast Cancer

Author

Milne, Roger L., primary, Goode, Ellen L., primary, García-Closas, Montserrat, primary, Couch, Fergus J., primary, Severi, Gianluca, primary, Hein, Rebecca, primary, Fredericksen, Zachary, primary, Malats, Núria, primary, Zamora, M. Pilar, primary, Pérez, Jose Ignacio Arias, primary, Benítez, Javier, primary, Dörk, Thilo, primary, Schürmann, Peter, primary, Karstens, Johann H., primary, Hillemanns, Peter, primary, Cox, Angela, primary, Brock, Ian W., primary, Elliot, Graeme, primary, Cross, Simon S., primary, Seal, Sheila, primary, Turnbull, Clare, primary, Renwick, Anthony, primary, Rahman, Nazneen, primary, Shen, Chen-Yang, primary, Yu, Jyh-Cherng, primary, Huang, Chiun-Sheng, primary, Hou, Ming-Feng, primary, Nordestgaard, Børge G., primary, Bojesen, Stig E., primary, Lanng, Charlotte, primary, Alnæs, Grethe Grenaker, primary, Kristensen, Vessela, primary, Børrensen-Dale, Anne-Lise, primary, Hopper, John L., primary, Dite, Gillian S., primary, Apicella, Carmel, primary, Southey, Melissa C., primary, Lambrechts, Diether, primary, Yesilyurt, Betül T., primary, Floris, Giuseppe, primary, Leunen, Karin, primary, Sangrajrang, Suleeporn, primary, Gaborieau, Valerie, primary, Brennan, Paul, primary, McKay, James, primary, Chang-Claude, Jenny, primary, Wang-Gohrke, Shan, primary, Radice, Paolo, primary, Peterlongo, Paolo, primary, Manoukian, Siranoush, primary, Barile, Monica, primary, Giles, Graham G., primary, Baglietto, Laura, primary, John, Esther M., primary, Miron, Alexander, primary, Chanock, Stephen J., primary, Lissowska, Jolanta, primary, Sherman, Mark E., primary, Figueroa, Jonine D., primary, Bogdanova, Natalia V., primary, Antonenkova, Natalia N., primary, Zalutsky, Iosif V., primary, Rogov, Yuri I., primary, Fasching, Peter A., primary, Bayer, Christian M., primary, Ekici, Arif B., primary, Beckmann, Matthias W., primary, Brenner, Hermann, primary, Müller, Heiko, primary, Arndt, Volker, primary, Stegmaier, Christa, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Glendon, Gord, primary, Mulligan, Anna Marie, primary, Mannermaa, Arto, primary, Kataja, Vesa, primary, Kosma, Veli-Matti, primary, Hartikainen, Jaana M., primary, Meindl, Alfons, primary, Heil, Joerg, primary, Bartram, Claus R., primary, Schmutzler, Rita K., primary, Thomas, Gilles D., primary, Hoover, Robert N., primary, Fletcher, Olivia, primary, Gibson, Lorna J., primary, dos Santos Silva, Isabel, primary, Peto, Julian, primary, Nickels, Stefan, primary, Flesch-Janys, Dieter, primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Sawyer, Elinor, primary, Tomlinson, Ian, primary, Kerin, Michael, primary, Miller, Nicola, primary, Schmidt, Marjanka K., primary, Broeks, Annegien, primary, Van ‘t Veer, Laura J., primary, Tollenaar, Rob A.E.M., primary, Pharoah, Paul D.P., primary, Dunning, Alison M., primary, Pooley, Karen A., primary, Marme, Frederik, primary, Schneeweiss, Andreas, primary, Sohn, Christof, primary, Burwinkel, Barbara, primary, Jakubowska, Anna, primary, Lubinski, Jan, primary, Jaworska, Katarzyna, primary, Durda, Katarzyna, primary, Kang, Daehee, primary, Yoo, Keun-Young, primary, Noh, Dong-Young, primary, Ahn, Sei-Hyun, primary, Hunter, David J., primary, Hankinson, Susan E., primary, Kraft, Peter, primary, Lindstrom, Sara, primary, Chen, Xiaoqing, primary, Beesley, Jonathan, primary, Hamann, Ute, primary, Harth, Volker, primary, Justenhoven, Christina, primary, Winqvist, Robert, primary, Pylkäs, Katri, primary, Jukkola-Vuorinen, Arja, primary, Grip, Mervi, primary, Hooning, Maartje, primary, Hollestelle, Antoinette, primary, Oldenburg, Rogier A., primary, Tilanus-Linthorst, Madeleine, primary, Khusnutdinova, Elza, primary, Bermisheva, Marina, primary, Prokofieva, Darya, primary, Farahtdinova, Albina, primary, Olson, Janet E., primary, Wang, Xianshu, primary, Humphreys, Manjeet K., primary, Wang, Qin, primary, Chenevix-Trench, Georgia, primary, and Easton, Douglas F., primary

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2023
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43. Data from 19p13.1 Is a Triple-Negative–Specific Breast Cancer Susceptibility Locus

Author

Stevens, Kristen N., primary, Fredericksen, Zachary, primary, Vachon, Celine M., primary, Wang, Xianshu, primary, Margolin, Sara, primary, Lindblom, Annika, primary, Nevanlinna, Heli, primary, Greco, Dario, primary, Aittomäki, Kristiina, primary, Blomqvist, Carl, primary, Chang-Claude, Jenny, primary, Vrieling, Alina, primary, Flesch-Janys, Dieter, primary, Sinn, Hans-Peter, primary, Wang-Gohrke, Shan, primary, Nickels, Stefan, primary, Brauch, Hiltrud, primary, Ko, Yon-Dschun, primary, Fischer, Hans-Peter, primary, Schmutzler, Rita K., primary, Meindl, Alfons, primary, Bartram, Claus R., primary, Schott, Sarah, primary, Engel, Christoph, primary, Godwin, Andrew K., primary, Weaver, JoEllen, primary, Pathak, Harsh B., primary, Sharma, Priyanka, primary, Brenner, Hermann, primary, Müller, Heiko, primary, Arndt, Volker, primary, Stegmaier, Christa, primary, Miron, Penelope, primary, Yannoukakos, Drakoulis, primary, Stavropoulou, Alexandra, primary, Fountzilas, George, primary, Gogas, Helen J., primary, Swann, Ruth, primary, Dwek, Miriam, primary, Perkins, Annie, primary, Milne, Roger L., primary, Benítez, Javier, primary, Zamora, María Pilar, primary, Pérez, José Ignacio Arias, primary, Bojesen, Stig E., primary, Nielsen, Sune F., primary, Nordestgaard, Børge G., primary, Flyger, Henrik, primary, Guénel, Pascal, primary, Truong, Thérèse, primary, Menegaux, Florence, primary, Cordina-Duverger, Emilie, primary, Burwinkel, Barbara, primary, Marmé, Frederick, primary, Schneeweiss, Andreas, primary, Sohn, Christof, primary, Sawyer, Elinor, primary, Tomlinson, Ian, primary, Kerin, Michael J., primary, Peto, Julian, primary, Johnson, Nichola, primary, Fletcher, Olivia, primary, dos Santos Silva, Isabel, primary, Fasching, Peter A., primary, Beckmann, Matthias W., primary, Hartmann, Arndt, primary, Ekici, Arif B., primary, Lophatananon, Artitaya, primary, Muir, Kenneth, primary, Puttawibul, Puttisak, primary, Wiangnon, Surapon, primary, Schmidt, Marjanka K., primary, Broeks, Annegien, primary, Braaf, Linde M., primary, Rosenberg, Efraim H., primary, Hopper, John L., primary, Apicella, Carmel, primary, Park, Daniel J., primary, Southey, Melissa C., primary, Swerdlow, Anthony J., primary, Ashworth, Alan, primary, Orr, Nicholas, primary, Schoemaker, Minouk J., primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Bernstein, Leslie, primary, Dur, Christina Clarke, primary, Shen, Chen-Yang, primary, Yu, Jyh-Cherng, primary, Hsu, Huan-Ming, primary, Hsiung, Chia-Ni, primary, Hamann, Ute, primary, Dünnebier, Thomas, primary, Rüdiger, Thomas, primary, Ulmer, Hans Ulrich, primary, Pharoah, Paul P., primary, Dunning, Alison M., primary, Humphreys, Manjeet K., primary, Wang, Qin, primary, Cox, Angela, primary, Cross, Simon S., primary, Reed, Malcom W., primary, Hall, Per, primary, Czene, Kamila, primary, Ambrosone, Christine B., primary, Ademuyiwa, Foluso, primary, Hwang, Helena, primary, Eccles, Diana M., primary, Garcia-Closas, Montserrat, primary, Figueroa, Jonine D., primary, Sherman, Mark E., primary, Lissowska, Jolanta, primary, Devilee, Peter, primary, Seynaeve, Caroline, primary, Tollenaar, Rob A.E.M., primary, Hooning, Maartje J., primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Glendon, Gord, primary, Mulligan, Anna Marie, primary, Winqvist, Robert, primary, Pylkäs, Katri, primary, Jukkola-Vuorinen, Arja, primary, Grip, Mervi, primary, John, Esther M., primary, Miron, Alexander, primary, Alnæs, Grethe Grenaker, primary, Kristensen, Vessela, primary, Børresen-Dale, Anne-Lise, primary, Giles, Graham G., primary, Baglietto, Laura, primary, McLean, Catriona A., primary, Severi, Gianluca, primary, Kosel, Matthew L., primary, Pankratz, V.S., primary, Slager, Susan, primary, Olson, Janet E., primary, Radice, Paolo, primary, Peterlongo, Paolo, primary, Manoukian, Siranoush, primary, Barile, Monica, primary, Lambrechts, Diether, primary, Hatse, Sigrid, primary, Dieudonne, Anne-Sophie, primary, Christiaens, Marie-Rose, primary, Chenevix-Trench, Georgia, primary, Beesley, Jonathan, primary, Chen, Xiaoqing, primary, Mannermaa, Arto, primary, Kosma, Veli-Matti, primary, Hartikainen, Jaana M., primary, Soini, Ylermi, primary, Easton, Douglas F., primary, and Couch, Fergus J., primary

Published
2023
Full Text
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50. Supplementary Tables 1-13 from 19p13.1 Is a Triple-Negative–Specific Breast Cancer Susceptibility Locus

Author

Stevens, Kristen N., primary, Fredericksen, Zachary, primary, Vachon, Celine M., primary, Wang, Xianshu, primary, Margolin, Sara, primary, Lindblom, Annika, primary, Nevanlinna, Heli, primary, Greco, Dario, primary, Aittomäki, Kristiina, primary, Blomqvist, Carl, primary, Chang-Claude, Jenny, primary, Vrieling, Alina, primary, Flesch-Janys, Dieter, primary, Sinn, Hans-Peter, primary, Wang-Gohrke, Shan, primary, Nickels, Stefan, primary, Brauch, Hiltrud, primary, Ko, Yon-Dschun, primary, Fischer, Hans-Peter, primary, Schmutzler, Rita K., primary, Meindl, Alfons, primary, Bartram, Claus R., primary, Schott, Sarah, primary, Engel, Christoph, primary, Godwin, Andrew K., primary, Weaver, JoEllen, primary, Pathak, Harsh B., primary, Sharma, Priyanka, primary, Brenner, Hermann, primary, Müller, Heiko, primary, Arndt, Volker, primary, Stegmaier, Christa, primary, Miron, Penelope, primary, Yannoukakos, Drakoulis, primary, Stavropoulou, Alexandra, primary, Fountzilas, George, primary, Gogas, Helen J., primary, Swann, Ruth, primary, Dwek, Miriam, primary, Perkins, Annie, primary, Milne, Roger L., primary, Benítez, Javier, primary, Zamora, María Pilar, primary, Pérez, José Ignacio Arias, primary, Bojesen, Stig E., primary, Nielsen, Sune F., primary, Nordestgaard, Børge G., primary, Flyger, Henrik, primary, Guénel, Pascal, primary, Truong, Thérèse, primary, Menegaux, Florence, primary, Cordina-Duverger, Emilie, primary, Burwinkel, Barbara, primary, Marmé, Frederick, primary, Schneeweiss, Andreas, primary, Sohn, Christof, primary, Sawyer, Elinor, primary, Tomlinson, Ian, primary, Kerin, Michael J., primary, Peto, Julian, primary, Johnson, Nichola, primary, Fletcher, Olivia, primary, dos Santos Silva, Isabel, primary, Fasching, Peter A., primary, Beckmann, Matthias W., primary, Hartmann, Arndt, primary, Ekici, Arif B., primary, Lophatananon, Artitaya, primary, Muir, Kenneth, primary, Puttawibul, Puttisak, primary, Wiangnon, Surapon, primary, Schmidt, Marjanka K., primary, Broeks, Annegien, primary, Braaf, Linde M., primary, Rosenberg, Efraim H., primary, Hopper, John L., primary, Apicella, Carmel, primary, Park, Daniel J., primary, Southey, Melissa C., primary, Swerdlow, Anthony J., primary, Ashworth, Alan, primary, Orr, Nicholas, primary, Schoemaker, Minouk J., primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Bernstein, Leslie, primary, Dur, Christina Clarke, primary, Shen, Chen-Yang, primary, Yu, Jyh-Cherng, primary, Hsu, Huan-Ming, primary, Hsiung, Chia-Ni, primary, Hamann, Ute, primary, Dünnebier, Thomas, primary, Rüdiger, Thomas, primary, Ulmer, Hans Ulrich, primary, Pharoah, Paul P., primary, Dunning, Alison M., primary, Humphreys, Manjeet K., primary, Wang, Qin, primary, Cox, Angela, primary, Cross, Simon S., primary, Reed, Malcom W., primary, Hall, Per, primary, Czene, Kamila, primary, Ambrosone, Christine B., primary, Ademuyiwa, Foluso, primary, Hwang, Helena, primary, Eccles, Diana M., primary, Garcia-Closas, Montserrat, primary, Figueroa, Jonine D., primary, Sherman, Mark E., primary, Lissowska, Jolanta, primary, Devilee, Peter, primary, Seynaeve, Caroline, primary, Tollenaar, Rob A.E.M., primary, Hooning, Maartje J., primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Glendon, Gord, primary, Mulligan, Anna Marie, primary, Winqvist, Robert, primary, Pylkäs, Katri, primary, Jukkola-Vuorinen, Arja, primary, Grip, Mervi, primary, John, Esther M., primary, Miron, Alexander, primary, Alnæs, Grethe Grenaker, primary, Kristensen, Vessela, primary, Børresen-Dale, Anne-Lise, primary, Giles, Graham G., primary, Baglietto, Laura, primary, McLean, Catriona A., primary, Severi, Gianluca, primary, Kosel, Matthew L., primary, Pankratz, V.S., primary, Slager, Susan, primary, Olson, Janet E., primary, Radice, Paolo, primary, Peterlongo, Paolo, primary, Manoukian, Siranoush, primary, Barile, Monica, primary, Lambrechts, Diether, primary, Hatse, Sigrid, primary, Dieudonne, Anne-Sophie, primary, Christiaens, Marie-Rose, primary, Chenevix-Trench, Georgia, primary, Beesley, Jonathan, primary, Chen, Xiaoqing, primary, Mannermaa, Arto, primary, Kosma, Veli-Matti, primary, Hartikainen, Jaana M., primary, Soini, Ylermi, primary, Easton, Douglas F., primary, and Couch, Fergus J., primary

Published
2023
Full Text
View/download PDF

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