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1. Defining the r factor for post-trauma resilience and its neural predictors

Author

van Rooij, Sanne J. H., Santos, Justin L., Hinojosa, Cecilia A., Ely, Timothy D., Harnett, Nathaniel G., Murty, Vishnu P., Lebois, Lauren A. M., Jovanovic, Tanja, House, Stacey L., Bruce, Steven E., Beaudoin, Francesca L., An, Xinming, Neylan, Thomas C., Clifford, Gari D., Linnstaedt, Sarah D., Germine, Laura T., Bollen, Kenneth A., Rauch, Scott L., Haran, John P., Storrow, Alan B., Lewandowski, Christopher, Musey, Jr., Paul I., Hendry, Phyllis L., Sheikh, Sophia, Jones, Christopher W., Punches, Brittany E., Swor, Robert A., Pascual, Jose L., Seamon, Mark J., Harris, Erica, Pearson, Claire, Peak, David A., Merchant, Roland C., Domeier, Robert M., Rathlev, Niels K., O’Neil, Brian J., Sanchez, Leon D., Joormann, Jutta, Pizzagalli, Diego A., Sheridan, John F., Harte, Steven E., Kessler, Ronald C., Koenen, Karestan C., McLean, Samuel A., Ressler, Kerry J., and Stevens, Jennifer S.

Published
2024
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3. Mediators of the association between childhood trauma and pain sensitivity in adulthood: a Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network analysis

Author

Pierce, Jennifer, Harte, Steven E, Afari, Niloofar, Bradley, Catherine S, Griffith, James W, Kim, Jayoung, Lutgendorf, Susan, Naliboff, Bruce D, Rodriguez, Larissa V, Taple, Bayley J, Williams, David, Harris, Richard E, and Schrepf, Andrew

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Neurosciences, Clinical Research, Women's Health, Behavioral and Social Science, Chronic Pain, Pain Research, 2.1 Biological and endogenous factors, Adult, Child, Female, Humans, Male, Middle Aged, Adverse Childhood Experiences, Pain Threshold, Pelvic Pain, Psychological Trauma, Sexual Trauma, Trauma, Childhood abuse, Pain sensitivity, Quantitative sensory testing, MAPP Research Network, Medical and Health Sciences, Psychology and Cognitive Sciences, Anesthesiology, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

AbstractUrologic chronic pelvic pain syndrome (UCPPS) is a complex, debilitating condition in which patients often report nonpelvic pain in addition to localized pelvic pain. Understanding differential predictors of pelvic pain only vs widespread pain may provide novel pathways for intervention. This study leveraged baseline data from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network's Symptom Pattern Study to investigate the impact of childhood sexual and nonsexual violent trauma on pelvic and nonpelvic pain sensitivity among adult patients with UCPPS, as well as potential mediators of this association. Study participants who met inclusion criteria for UCPPS completed questionnaires assessing childhood and recent trauma, affective distress, cognitive dysfunction, and generalized sensory sensitivity. Experimental pain sensitivity was also evaluated using standardized pressure pain applied to the pubic region and the arm. Bivariate analyses showed that childhood violent trauma was associated with more nonviolent childhood trauma, more recent trauma, poorer adult functioning, and greater pain sensitivity at the pubic region, but not pain sensitivity at the arm. Path analysis suggested that childhood violent trauma was indirectly associated with pain sensitivity at both sites and that this indirect association was primarily mediated by generalized sensory sensitivity. More experiences of recent trauma also contributed to these indirect effects. The findings suggest that, among participants with UCPPS, childhood violent trauma may be associated with heightened pain sensitivity to the extent that trauma history is associated with a subsequent increase in generalized sensory sensitivity.

Published
2023

4. Predicting chronic postsurgical pain: current evidence and a novel program to develop predictive biomarker signatures

Author

Sluka, Kathleen A, Wager, Tor D, Sutherland, Stephani P, Labosky, Patricia A, Balach, Tessa, Bayman, Emine O, Berardi, Giovanni, Brummett, Chad M, Burns, John, Buvanendran, Asokumar, Caffo, Brian, Calhoun, Vince D, Clauw, Daniel, Chang, Andrew, Coffey, Christopher S, Dailey, Dana L, Ecklund, Dixie, Fiehn, Oliver, Fisch, Kathleen M, Law, Laura A Frey, Harris, Richard E, Harte, Steven E, Howard, Timothy D, Jacobs, Joshua, Jacobs, Jon M, Jepsen, Kristen, Johnston, Nicolas, Langefeld, Carl D, Laurent, Louise C, Lenzi, Rebecca, Lindquist, Martin A, Lokshin, Anna, Kahn, Ari, McCarthy, Robert J, Olivier, Michael, Porter, Linda, Qian, Wei-Jun, Sankar, Cheryse A, Satterlee, John, Swensen, Adam C, Vance, Carol GT, Waljee, Jennifer, Wandner, Laura D, Williams, David A, Wixson, Richard L, Zhou, Xiaohong Joe, and Consortium, the A2CPS

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Chronic Pain, Clinical Research, Prevention, Pain Research, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, 2.1 Biological and endogenous factors, Aetiology, Musculoskeletal, Good Health and Well Being, Humans, Proteomics, Pain, Postoperative, Acute Pain, Biomarkers, Pain, Chronic pain, Postsurgical pain, Biomarker, Biosignatures, Omics, Brain imaging, Psychosocial, A2CPS Consortium, Medical and Health Sciences, Psychology and Cognitive Sciences, Anesthesiology, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

AbstractChronic pain affects more than 50 million Americans. Treatments remain inadequate, in large part, because the pathophysiological mechanisms underlying the development of chronic pain remain poorly understood. Pain biomarkers could potentially identify and measure biological pathways and phenotypical expressions that are altered by pain, provide insight into biological treatment targets, and help identify at-risk patients who might benefit from early intervention. Biomarkers are used to diagnose, track, and treat other diseases, but no validated clinical biomarkers exist yet for chronic pain. To address this problem, the National Institutes of Health Common Fund launched the Acute to Chronic Pain Signatures (A2CPS) program to evaluate candidate biomarkers, develop them into biosignatures, and discover novel biomarkers for chronification of pain after surgery. This article discusses candidate biomarkers identified by A2CPS for evaluation, including genomic, proteomic, metabolomic, lipidomic, neuroimaging, psychophysical, psychological, and behavioral measures. Acute to Chronic Pain Signatures will provide the most comprehensive investigation of biomarkers for the transition to chronic postsurgical pain undertaken to date. Data and analytic resources generatedby A2CPS will be shared with the scientific community in hopes that other investigators will extract valuable insights beyond A2CPS's initial findings. This article will review the identified biomarkers and rationale for including them, the current state of the science on biomarkers of the transition from acute to chronic pain, gaps in the literature, and how A2CPS will address these gaps.

Published
2023

6. Disentangling sex differences in PTSD risk factors

Author

Haering, Stephanie, Seligowski, Antonia V., Linnstaedt, Sarah D., Michopoulos, Vasiliki, House, Stacey L., Beaudoin, Francesca L., An, Xinming, Neylan, Thomas C., Clifford, Gari D., Germine, Laura T., Rauch, Scott L., Haran, John P., Storrow, Alan B., Lewandowski, Christopher, Musey, Jr, Paul I., Hendry, Phyllis L., Sheikh, Sophia, Jones, Christopher W., Punches, Brittany E., Swor, Robert A., Gentile, Nina T., Hudak, Lauren A., Pascual, Jose L., Seamon, Mark J., Pearson, Claire, Peak, David A., Merchant, Roland C., Domeier, Robert M., Rathlev, Niels K., O’Neil, Brian J., Sanchez, Leon D., Bruce, Steven E., Harte, Steven E., McLean, Samuel A., Kessler, Ronald C., Koenen, Karestan C., Powers, Abigail, and Stevens, Jennifer S.

Published
2024
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7. Biobehavioral Assessments in BACPAC: Recommendations, Rationale, and Methods

Author

Greco, Carol M, Wasan, Ajay D, Schneider, Michael J, Mehling, Wolf, Williams, David A, Darwin, Jessa, and Harte, Steven E

Subjects
Allied Health and Rehabilitation Science, Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Neurosciences, Clinical Research, Pain Research, Behavioral and Social Science, Mind and Body, Chronic Pain, Mental Health, Basic Behavioral and Social Science, United States, Humans, Research Design, Low Back Pain, Advisory Committees, Pain Measurement, National Institutes of Health (U.S.), Behavioral Assessments, Psychosocial Assessments, Patient-Reported Outcomes, Quantitative Sensory Testing, Chronic Low Back Pain, Pharmacology and Pharmaceutical Sciences, Public Health and Health Services, Anesthesiology, Clinical sciences, Health services and systems, Clinical and health psychology
Abstract

The Biobehavioral Working Group of BACPAC was charged to evaluate a range of psychosocial, psychophysical, and behavioral domains relevant to chronic low back pain, and recommend specific assessment tools and procedures to harmonize biobehavioral data collection across the consortium. Primary references and sources for measure selection were the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials, the Minimum Data Set from the National Institutes of Health (NIH) Research Task Force on Standards for Chronic Low Back Pain, the Patient-Reported Outcomes Measurement Information System, and NeuroQOL. The questionnaire's recommendations supplemented the NIH HEAL Common Data Elements and BACPAC Minimum Data Set. Five domains were identified for inclusion: Pain Characteristics and Qualities; Pain-Related Psychosocial/Behavioral Factors; General Psychosocial Factors; Lifestyle Choices; and Social Determinants of Health/Social Factors. The Working Group identified best practices for required and optional Quantitative Sensory Testing of psychophysical pain processing for use in BACPAC projects.

Published
2023

8. The Back Pain Consortium (BACPAC) Research Program: Structure, Research Priorities, and Methods

Author

Mauck, Matthew C, Lotz, Jeffrey, Psioda, Matthew A, Carey, Timothy S, Clauw, Daniel J, Majumdar, Sharmila, Marras, William S, Vo, Nam, Aylward, Ayleen, Hoffmeyer, Anna, Zheng, Patricia, Ivanova, Anastasia, McCumber, Micah, Carson, Christiane, Anstrom, Kevin J, Bowden, Anton E, Dalton, Diane, Derr, Leslie, Dufour, Jonathan, Fields, Aaron J, Fritz, Julie, Hassett, Afton L, Harte, Steven E, Hue, Trisha F, Krug, Roland, Loggia, Marco L, Mageswaran, Prasath, McLean, Samuel A, Mitchell, Ulrike H, O’Neill, Conor, Pedoia, Valentina, Quirk, David Adam, Rhon, Daniel I, Rieke, Viola, Shah, Lubdha, Sowa, Gwendolyn, Spiegel, Brennan, Wasan, Ajay D, Wey, Hsiao-Ying, and LaVange, Lisa

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Substance Misuse, Neurosciences, Clinical Research, Pain Research, Chronic Pain, Drug Abuse (NIDA only), Good Health and Well Being, Adult, Humans, Research Design, Analgesics, Opioid, Advisory Committees, Pain Measurement, Low Back Pain, Opioid-Related Disorders, Chronic low back pain, BACPAC Research Consortium, Harmonization, Back Pain, HEAL, SMART, clinical trials, chronic disease, chronic pain, low back pain, Pharmacology and Pharmaceutical Sciences, Public Health and Health Services, Anesthesiology, Clinical sciences, Health services and systems, Clinical and health psychology
Abstract

In 2019, the National Health Interview survey found that nearly 59% of adults reported pain some, most, or every day in the past 3 months, with 39% reporting back pain, making back pain the most prevalent source of pain, and a significant issue among adults. Often, identifying a direct, treatable cause for back pain is challenging, especially as it is often attributed to complex, multifaceted issues involving biological, psychological, and social components. Due to the difficulty in treating the true cause of chronic low back pain (cLBP), an over-reliance on opioid pain medications among cLBP patients has developed, which is associated with increased prevalence of opioid use disorder and increased risk of death. To combat the rise of opioid-related deaths, the National Institutes of Health (NIH) initiated the Helping to End Addiction Long-TermSM (HEAL) initiative, whose goal is to address the causes and treatment of opioid use disorder while also seeking to better understand, diagnose, and treat chronic pain. The NIH Back Pain Consortium (BACPAC) Research Program, a network of 14 funded entities, was launched as a part of the HEAL initiative to help address limitations surrounding the diagnosis and treatment of cLBP. This paper provides an overview of the BACPAC research program's goals and overall structure, and describes the harmonization efforts across the consortium, define its research agenda, and develop a collaborative project which utilizes the strengths of the network. The purpose of this paper is to serve as a blueprint for other consortia tasked with the advancement of pain related science.

Published
2023

9. Clinically Important Differences for Pain and Urinary Symptoms in Urological Chronic Pelvic Pain Syndrome: A MAPP Network Study

Author

Stephens-Shields, Alisa J, Lai, H Henry, Landis, J Richard, Kreder, Karl, Rodriguez, Larissa V, Naliboff, Bruce D, Afari, Niloofar, Sutcliffe, Siobhan, Moldwin, Robert, Griffith, James W, Clemens, J Quentin, Bradley, Catherine S, Quallich, Susan, Gupta, Priyanka, Harte, Steven E, and Farrar, John T

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Chronic Pain, Pain Research, Clinical Research, Urologic Diseases, Management of diseases and conditions, 7.3 Management and decision making, Renal and urogenital, Humans, Male, Female, Prostatitis, Pelvic Pain, Cystitis, Interstitial, Depression, minimal clinically important difference, treatment outcome, research design, pelvic pain, cystitis, interstitial, cystitis, interstitial
Abstract

PurposeSymptom heterogeneity in interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, collectively termed urological chronic pelvic pain syndrome, has resulted in difficulty in defining appropriate clinical trial endpoints. We determine clinically important differences for 2 primary symptom measures, pelvic pain severity and urinary symptom severity, and evaluate subgroup differences.Materials and methodsThe Multidisciplinary Approach to the Study of Chronic Pelvic Pain Symptom Patterns Study enrolled individuals with urological chronic pelvic pain syndrome. We defined clinically important differences by associating changes in pelvic pain severity and urinary symptom severity over 3 to 6 months with marked improvement on a global response assessment using regression and receiver operating characteristic curves. We evaluated clinically important differences for absolute and percent change and examined differences in clinically important differences by sex-diagnosis, presence of Hunner lesions, pain type, pain widespreadness, and baseline symptom severity.ResultsAn absolute change of -4 was clinically important in pelvic pain severity among all patients, but clinically important difference estimates differed by pain type, presence of Hunner lesions, and baseline severity. Pelvic pain severity clinically important difference estimates for percent change were more consistent across subgroups and ranged from 30% to 57%. The absolute change urinary symptom severity clinically important difference was -3 for female participants and -2 for male participants with chronic prostatitis/chronic pelvic pain syndrome only. Patients with greater baseline severity required larger decreases in symptoms to feel improved. Estimated clinically important differences had lower accuracy among participants with low baseline symptoms.ConclusionsA reduction of 30%-50% in pelvic pain severity is a clinically meaningful endpoint for future therapeutic trials in urological chronic pelvic pain syndrome. Urinary symptom severity clinically important differences are more appropriately defined separately for male and female participants.

Published
2023

10. Internal capsule microstructure mediates the relationship between childhood maltreatment and PTSD following adulthood trauma exposure

Author

Wong, Samantha A., Lebois, Lauren A. M., Ely, Timothy D., van Rooij, Sanne J. H., Bruce, Steven E., Murty, Vishnu P., Jovanovic, Tanja, House, Stacey L., Beaudoin, Francesca L., An, Xinming, Zeng, Donglin, Neylan, Thomas C., Clifford, Gari D., Linnstaedt, Sarah D., Germine, Laura T., Bollen, Kenneth A., Rauch, Scott L., Haran, John P., Storrow, Alan B., Lewandowski, Christopher, Musey, Jr., Paul I., Hendry, Phyllis L., Sheikh, Sophia, Jones, Christopher W., Punches, Brittany E., Kurz, Michael C., Swor, Robert A., Hudak, Lauren A., Pascual, Jose L., Seamon, Mark J., Pearson, Claire, Peak, David A., Merchant, Roland C., Domeier, Robert M., Rathlev, Niels K., O’Neil, Brian J., Sergot, Paulina, Sanchez, Leon D., Miller, Mark W., Pietrzak, Robert H., Joormann, Jutta, Barch, Deanna M., Pizzagalli, Diego A., Harte, Steven E., Elliott, James M., Kessler, Ronald C., Koenen, Karestan C., McLean, Samuel A., Ressler, Kerry J., Stevens, Jennifer S., and Harnett, Nathaniel G.

Published
2023
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11. Clinical Phenotyping for Pain Mechanisms in Urologic Chronic Pelvic Pain Syndromes: A MAPP Research Network Study

Author

Schrepf, Andrew, Gallop, Robert, Naliboff, Bruce, Harte, Steven E, Afari, Niloofar, Lai, H Henry, Pontari, Michel, McKernan, Lindsey C, Strachan, Eric, Kreder, Karl J, As-Sanie, Sawsan A, Rodriguez, Larissa V, Griffith, James W, Williams, David A, and Network, Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Clinical Research, Peripheral Neuropathy, Urologic Diseases, Neurodegenerative, Chronic Pain, Pain Research, 7.1 Individual care needs, Management of diseases and conditions, 2.1 Biological and endogenous factors, Aetiology, Neurological, Chronic Disease, Female, Humans, Male, Pelvic Pain, Pelvis, Syndrome, Nociceptive pain, chronic pain, neuropathic pain, central nervous system sensitization, cystitis, Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network
Abstract

Three categories of pain mechanisms are recognized as contributing to pain perception: nociceptive, neuropathic, and nociplastic (ie, central nervous system augmented pain processing). We use validated questionnaires to identify pain mechanisms in Urologic Chronic Pelvic Pain Syndrome (UCCPS) patients (n = 568, female = 378, male = 190) taking part in the Symptom Patterns Study of the Multidisciplinary Approach to the study of chronic Pelvic Pain Research Network. A cutoff score of 12 on the painDETECT questionnaire (-1 to 38) was used to classify patients into the neuropathic category while the median score of 7 on the fibromyalgia survey criteria (0-31) was used to classify patients into the nociplastic category. Categories were compared on demographic, clinical, psychosocial, psychophysical and medication variables. At baseline, 43% of UCPPS patients were classified as nociceptive-only, 8% as neuropathic only, 27% as nociceptive+nociplastic, and 22% as neuropathic+nociplastic. Across outcomes nociceptive-only patients had the least severe symptoms and neuropathic+nociplastic patients the most severe. Neuropathic pain was associated with genital pain and/or sensitivity on pelvic exam, while nociplastic pain was associated with comorbid pain conditions, psychosocial difficulties, and increased pressure pain sensitivity outside the pelvis. A self-report method classifying individuals on pain mechanisms reveals clinical differences that could inform clinical trials and novel targets for treatment. PERSPECTIVE: This article presents differences in clinical characteristics based on a simple self-report method of classifying pain mechanisms for Urologic Chronic Pelvic Pain Syndrome patients. This method can be easily applied to other chronic pain conditions and may be useful for exploring pathophysiology in pain subtypes.

Published
2022

12. Longitudinal associations between five factor model and impulsive personality traits and PTSD symptoms: Findings from the AURORA study

Author

Hyatt, Courtland S., Reddi, Preethi J., Sharpe, Brinkley M., Michopoulos, Vasiliki, van Rooij, Sanne J.H., House, Stacey L., Beaudoin, Francesca L., An, Xinming, Stevens, Jennifer S., Zeng, Donglin, Neylan, Thomas C., Clifford, Gari D., Linnstaedt, Sarah D., Germine, Laura T., Bollen, Kenneth A., Rauch, Scott L., Haran, John P., Lewandowski, Christopher, Musey, Paul I., Hendry, Phyllis L., Sheikh, Sophia, Jones, Christopher W., Punches, Brittany E., Kurz, Michael C., Swor, Robert A., Hudak, Lauren A., Pascual, Jose L., Seamon, Mark J., Harris, Erica, Pearson, Claire, Peak, David A., Merchant, Roland C., Domeier, Robert M., Rathlev, Niels K., Sergot, Paulina, Sanchez, Leon D., Bruce, Steven E., Miller, Mark W., Pietrzak, Robert H., Joormann, Jutta, Pizzagalli, Diego A., Sheridan, John F., Smoller, Jordan W., Harte, Steven E., Elliott, James M., McLean, Samuel A., Kessler, Ronald C., Ressler, Kerry J., Koenen, Karestan C., and Maples-Keller, Jessica L.

Published
2024
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14. Probing the neurocardiac circuit in trauma and posttraumatic stress

Author

Seligowski, Antonia V., Harnett, Nathaniel G., Ellis, Robyn A., Grasser, Lana R., Hanif, Mubeena, Wiltshire, Charis, Ely, Timothy D., Lebois, Lauren A.M., van Rooij, Sanne J.H., House, Stacey L., Beaudoin, Francesca L., An, Xinming, Neylan, Thomas C., Clifford, Gari D., Linnstaedt, Sarah D., Germine, Laura T., Bollen, Kenneth A., Rauch, Scott L., Haran, John P., Storrow, Alan B., Lewandowski, Christopher, Musey, Paul I., Jr., Hendry, Phyllis L., Sheikh, Sophia, Jones, Christopher W., Punches, Brittany E., Swor, Robert A., Hudak, Lauren A., Pascual, Jose L., Seamon, Mark J., Harris, Erica, Pearson, Claire, Peak, David A., Merchant, Roland C., Domeier, Robert M., Rathlev, Niels K., O’Neil, Brian J., Sergot, Paulina, Sanchez, Leon D., Bruce, Steven E., Harte, Steven E., Koenen, Karestan C., Kessler, Ronald C., McLean, Samuel A., Ressler, Kerry J., Stevens, Jennifer S., and Jovanovic, Tanja

Published
2024
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15. Sex Differences in Response Inhibition–Related Neural Predictors of Posttraumatic Stress Disorder in Civilians With Recent Trauma

Author

Borst, Bibian, Jovanovic, Tanja, House, Stacey L., Bruce, Steven E., Harnett, Nathaniel G., Roeckner, Alyssa R., Ely, Timothy D., Lebois, Lauren A.M., Young, Dmitri, Beaudoin, Francesca L., An, Xinming, Neylan, Thomas C., Clifford, Gari D., Linnstaedt, Sarah D., Germine, Laura T., Bollen, Kenneth A., Rauch, Scott L., Haran, John P., Storrow, Alan B., Lewandowski, Christopher, Musey, Paul I., Jr., Hendry, Phyllis L., Sheikh, Sophia, Jones, Christopher W., Punches, Brittany E., Hudak, Lauren A., Pascual, Jose L., Seamon, Mark J., Datner, Elizabeth M., Pearson, Claire, Peak, David A., Domeier, Robert M., Rathlev, Niels K., O’Neil, Brian J., Sergot, Paulina, Sanchez, Leon D., Harte, Steven E., Koenen, Karestan C., Kessler, Ronald C., McLean, Samuel A., Ressler, Kerry J., Stevens, Jennifer S., and van Rooij, Sanne J.H.

Published
2024
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16. Intensive longitudinal assessment following index trauma to predict development of PTSD using machine learning

Author

Horwitz, Adam, McCarthy, Kaitlyn, House, Stacey L., Beaudoin, Francesca L., An, Xinming, Neylan, Thomas C., Clifford, Gari D., Linnstaedt, Sarah D., Germine, Laura T., Rauch, Scott L., Haran, John P., Storrow, Alan B., Lewandowski, Christopher, Musey Jr., Paul I., Hendry, Phyllis L., Sheikh, Sophia, Jones, Christopher W., Punches, Brittany E., Swor, Robert A., Hudak, Lauren A., Pascual, Jose L., Seamon, Mark J., Harris, Erica, Pearson, Claire, Peak, David A., Domeier, Robert M., Rathlev, Niels K., Sergot, Paulina, Sanchez, Leon D., Bruce, Steven E., Joormann, Jutta, Harte, Steven E., Koenen, Karestan C., McLean, Samuel A., and Sen, Srijan

Published
2024
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17. Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort

Author

Beaudoin, Francesca L., An, Xinming, Basu, Archana, Ji, Yinyao, Liu, Mochuan, Kessler, Ronald C., Doughtery, Robert F., Zeng, Donglin, Bollen, Kenneth A., House, Stacey L., Stevens, Jennifer S., Neylan, Thomas C., Clifford, Gari D., Jovanovic, Tanja, Linnstaedt, Sarah D., Germine, Laura T., Rauch, Scott L., Haran, John P., Storrow, Alan B., Lewandowski, Christopher, Musey, Jr., Paul I., Hendry, Phyllis L., Sheikh, Sophia, Jones, Christopher W., Punches, Brittany E., Kurz, Michael C., Swor, Robert A., Murty, Vishnu P., McGrath, Meghan E., Hudak, Lauren A., Pascual, Jose L., Datner, Elizabeth M., Chang, Anna M., Pearson, Claire, Peak, David A., Merchant, Roland C., Domeier, Robert M., Rathlev, Niels K., Neil, Brian J. O’, Sergot, Paulina, Sanchez, Leon D., Bruce, Steven E., Baker, Justin T., Joormann, Jutta, Miller, Mark W., Pietrzak, Robert H., Barch, Deanna M., Pizzagalli, Diego A., Sheridan, John F., Smoller, Jordan W., Harte, Steven E., Elliott, James M., Koenen, Karestan C., Ressler, Kerry J., and McLean, Samuel A.

Published
2023
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18. Structural inequities contribute to racial/ethnic differences in neurophysiological tone, but not threat reactivity, after trauma exposure

Author

Harnett, Nathaniel G., Fani, Negar, Carter, Sierra, Sanchez, Leon D., Rowland, Grace E., Davie, William M., Guzman, Camilo, Lebois, Lauren A. M., Ely, Timothy D., van Rooij, Sanne J. H., Seligowski, Antonia V., Winters, Sterling, Grasser, Lana R., Musey, Jr., Paul I., Seamon, Mark J., House, Stacey L., Beaudoin, Francesca L., An, Xinming, Zeng, Donglin, Neylan, Thomas C., Clifford, Gari D., Linnstaedt, Sarah D., Germine, Laura T., Bollen, Kenneth A., Rauch, Scott L., Haran, John P., Storrow, Alan B., Lewandowski, Christopher, Hendry, Phyllis L., Sheikh, Sophia, Jones, Christopher W., Punches, Brittany E., Swor, Robert A., Hudak, Lauren A., Pascual, Jose L., Harris, Erica, Chang, Anna M., Pearson, Claire, Peak, David A., Merchant, Roland C., Domeier, Robert M., Rathlev, Niels K., Bruce, Steven E., Miller, Mark W., Pietrzak, Robert H., Joormann, Jutta, Barch, Deanna M., Pizzagalli, Diego A., Harte, Steven E., Elliott, James M., Kessler, Ronald C., Koenen, Karestan C., McLean, Samuel A., Jovanovic, Tanja, Stevens, Jennifer S., and Ressler, Kerry J.

Published
2023
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19. Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol

Author

Berardi, Giovanni, Frey-Law, Laura, Sluka, Kathleen A, Bayman, Emine O, Coffey, Christopher S, Ecklund, Dixie, Vance, Carol GT, Dailey, Dana L, Burns, John, Buvanendran, Asokumar, McCarthy, Robert J, Jacobs, Joshua, Zhou, Xiaohong Joe, Wixson, Richard, Balach, Tessa, Brummett, Chad M, Clauw, Daniel, Colquhoun, Douglas, Harte, Steven E, Harris, Richard E, Williams, David A, Chang, Andrew C, Waljee, Jennifer, Fisch, Kathleen M, Jepsen, Kristen, Laurent, Louise C, Olivier, Michael, Langefeld, Carl D, Howard, Timothy D, Fiehn, Oliver, Jacobs, Jon M, Dakup, Panshak, Qian, Wei-Jun, Swensen, Adam C, Lokshin, Anna, Lindquist, Martin, Caffo, Brian S, Crainiceanu, Ciprian, Zeger, Scott, Kahn, Ari, Wager, Tor, Taub, Margaret, Ford, James, Sutherland, Stephani P, and Wandner, Laura D

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Clinical Research, Prevention, Chronic Pain, Pain Research, Neurological, Musculoskeletal, Good Health and Well Being, postsurgical pain, thoracic surgery, pain, biomarker, risk factors, protocol, knee arthroplasty, Biomedical and clinical sciences, Health sciences
Abstract

Chronic pain has become a global health problem contributing to years lived with disability and reduced quality of life. Advances in the clinical management of chronic pain have been limited due to incomplete understanding of the multiple risk factors and molecular mechanisms that contribute to the development of chronic pain. The Acute to Chronic Pain Signatures (A2CPS) Program aims to characterize the predictive nature of biomarkers (brain imaging, high-throughput molecular screening techniques, or "omics," quantitative sensory testing, patient-reported outcome assessments and functional assessments) to identify individuals who will develop chronic pain following surgical intervention. The A2CPS is a multisite observational study investigating biomarkers and collective biosignatures (a combination of several individual biomarkers) that predict susceptibility or resilience to the development of chronic pain following knee arthroplasty and thoracic surgery. This manuscript provides an overview of data collection methods and procedures designed to standardize data collection across multiple clinical sites and institutions. Pain-related biomarkers are evaluated before surgery and up to 3 months after surgery for use as predictors of patient reported outcomes 6 months after surgery. The dataset from this prospective observational study will be available for researchers internal and external to the A2CPS Consortium to advance understanding of the transition from acute to chronic postsurgical pain.

Published
2022

20. Author Correction: Defining the r factor for post-trauma resilience and its neural predictors

Author

van Rooij, Sanne J. H., Santos, Justin L., Hinojosa, Cecilia A., Ely, Timothy D., Harnett, Nathaniel G., Murty, Vishnu P., Lebois, Lauren A. M., Jovanovic, Tanja, House, Stacey L., Bruce, Steven E., Beaudoin, Francesca L., An, Xinming, Neylan, Thomas C., Clifford, Gari D., Linnstaedt, Sarah D., Germine, Laura T., Bollen, Kenneth A., Rauch, Scott L., Haran, John P., Storrow, Alan B., Lewandowski, Christopher, Musey, Jr., Paul I., Hendry, Phyllis L., Sheikh, Sophia, Jones, Christopher W., Punches, Brittany E., Swor, Robert A., Pascual, Jose L., Seamon, Mark J., Harris, Erica, Pearson, Claire, Peak, David A., Merchant, Roland C., Domeier, Robert M., Rathlev, Niels K., O’Neil, Brian J., Sanchez, Leon D., Joormann, Jutta, Pizzagalli, Diego A., Sheridan, John F., Harte, Steven E., Kessler, Ronald C., Koenen, Karestan C., McLean, Samuel A., Ressler, Kerry J., and Stevens, Jennifer S.

Published
2024
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22. Prior Sexual Trauma Exposure Impacts Posttraumatic Dysfunction and Neural Circuitry Following a Recent Traumatic Event in the AURORA Study

Author

Rowland, Grace E., Roeckner, Alyssa, Ely, Timothy D., Lebois, Lauren A.M., van Rooij, Sanne J.H., Bruce, Steven E., Jovanovic, Tanja, House, Stacey L., Beaudoin, Francesca L., An, Xinming, Neylan, Thomas C., Clifford, Gari D., Linnstaedt, Sarah D., Germine, Laura T., Rauch, Scott L., Haran, John P., Storrow, Alan B., Lewandowski, Christopher, Musey, Paul I., Jr., Hendry, Phyllis L., Sheikh, Sophia, Jones, Christopher W., Punches, Brittany E., Kurz, Michael C., Gentile, Nina T., Hudak, Lauren A., Pascual, Jose L., Seamon, Mark J., Harris, Erica, Pearson, Claire, Merchant, Roland C., Domeier, Robert M., Rathlev, Niels K., Sergot, Paulina, Sanchez, Leon D., Miller, Mark W., Pietrzak, Robert H., Joormann, Jutta, Pizzagalli, Diego A., Sheridan, John F., Smoller, Jordan W., Harte, Steven E., Elliott, James M., Kessler, Ronald C., Koenen, Karestan C., McLean, Samuel A., Ressler, Kerry J., Stevens, Jennifer S., and Harnett, Nathaniel G.

Published
2023
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25. The AURORA Study: a longitudinal, multimodal library of brain biology and function after traumatic stress exposure

Author

McLean, Samuel A, Ressler, Kerry, Koenen, Karestan Chase, Neylan, Thomas, Germine, Laura, Jovanovic, Tanja, Clifford, Gari D, Zeng, Donglin, An, Xinming, Linnstaedt, Sarah, Beaudoin, Francesca, House, Stacey, Bollen, Kenneth A, Musey, Paul, Hendry, Phyllis, Jones, Christopher W, Lewandowski, Christopher, Swor, Robert, Datner, Elizabeth, Mohiuddin, Kamran, Stevens, Jennifer S, Storrow, Alan, Kurz, Michael Christopher, McGrath, Meghan E, Fermann, Gregory J, Hudak, Lauren A, Gentile, Nina, Chang, Anna Marie, Peak, David A, Pascual, Jose L, Seamon, Mark J, Sergot, Paulina, Peacock, W Frank, Diercks, Deborah, Sanchez, Leon D, Rathlev, Niels, Domeier, Robert, Haran, John Patrick, Pearson, Claire, Murty, Vishnu P, Insel, Thomas R, Dagum, Paul, Onnela, Jukka-Pekka, Bruce, Steven E, Gaynes, Bradley N, Joormann, Jutta, Miller, Mark W, Pietrzak, Robert H, Buysse, Daniel J, Pizzagalli, Diego A, Rauch, Scott L, Harte, Steven E, Young, Larry J, Barch, Deanna M, Lebois, Lauren AM, van Rooij, Sanne JH, Luna, Beatriz, Smoller, Jordan W, Dougherty, Robert F, Pace, Thaddeus WW, Binder, Elisabeth, Sheridan, John F, Elliott, James M, Basu, Archana, Fromer, Menachem, Parlikar, Tushar, Zaslavsky, Alan M, and Kessler, Ronald

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical and Health Psychology, Clinical Sciences, Psychology, Clinical Research, Brain Disorders, Behavioral and Social Science, Mental Health, Prevention, Genetics, Neurosciences, Mental health, Brain, Female, Humans, Longitudinal Studies, Male, Military Personnel, Risk Factors, Stress Disorders, Post-Traumatic, Stress Disorders, Traumatic, Veterans, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

Adverse posttraumatic neuropsychiatric sequelae (APNS) are common among civilian trauma survivors and military veterans. These APNS, as traditionally classified, include posttraumatic stress, postconcussion syndrome, depression, and regional or widespread pain. Traditional classifications have come to hamper scientific progress because they artificially fragment APNS into siloed, syndromic diagnoses unmoored to discrete components of brain functioning and studied in isolation. These limitations in classification and ontology slow the discovery of pathophysiologic mechanisms, biobehavioral markers, risk prediction tools, and preventive/treatment interventions. Progress in overcoming these limitations has been challenging because such progress would require studies that both evaluate a broad spectrum of posttraumatic sequelae (to overcome fragmentation) and also perform in-depth biobehavioral evaluation (to index sequelae to domains of brain function). This article summarizes the methods of the Advancing Understanding of RecOvery afteR traumA (AURORA) Study. AURORA conducts a large-scale (n = 5000 target sample) in-depth assessment of APNS development using a state-of-the-art battery of self-report, neurocognitive, physiologic, digital phenotyping, psychophysical, neuroimaging, and genomic assessments, beginning in the early aftermath of trauma and continuing for 1 year. The goals of AURORA are to achieve improved phenotypes, prediction tools, and understanding of molecular mechanisms to inform the future development and testing of preventive and treatment interventions.

Published
2020

26. Derivation and Validation of a Brief Emergency Department-Based Prediction Tool for Posttraumatic Stress After Motor Vehicle Collision

Author

Jones, Christopher W., An, Xinming, Ji, Yinyao, Liu, Mochuan, Zeng, Donglin, House, Stacey L., Beaudoin, Francesca L., Stevens, Jennifer S., Neylan, Thomas C., Clifford, Gari D., Jovanovic, Tanja, Linnstaedt, Sarah D., Germine, Laura T., Bollen, Kenneth A., Rauch, Scott L., Haran, John P., Storrow, Alan B., Lewandowski, Christopher, Musey, Paul I., Jr., Hendry, Phyllis L., Sheikh, Sophia, Punches, Brittany E., Lyons, Michael S., Kurz, Michael C., Swor, Robert A., McGrath, Meghan E., Hudak, Lauren A., Pascual, Jose L., Seamon, Mark J., Datner, Elizabeth M., Harris, Erica, Chang, Anna M., Pearson, Claire, Peak, David A., Merchant, Roland C., Domeier, Robert M., Rathlev, Niels K., O'Neil, Brian J., Sergot, Paulina, Sanchez, Leon D., Bruce, Steven E., Miller, Mark W., Pietrzak, Robert H., Joormann, Jutta, Barch, Deanna M., Pizzagalli, Diego A., Sheridan, John F., Smoller, Jordan W., Harte, Steven E., Elliott, James M., Koenen, Karestan C., Ressler, Kerry J., Kessler, Ronald C., and McLean, Samuel A.

Published
2023
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28. Anxiety sensitivity as a transdiagnostic risk factor for trajectories of adverse posttraumatic neuropsychiatric sequelae in the AURORA study

Author

Short, Nicole A., van Rooij, Sanne J.H., Murty, Vishnu P., Stevens, Jennifer S., An, Xinming, Ji, Yinyao, McLean, Samuel A., House, Stacey L., Beaudoin, Francesca L., Zeng, Donglin, Neylan, Thomas C., Clifford, Gari D., Linnstaedt, Sarah D., Germine, Laura T., Bollen, Kenneth A., Rauch, Scott L., Haran, John P., Lewandowski, Christopher, Musey, Paul I., Jr., Hendry, Phyllis L., Sheikh, Sophia, Jones, Christopher W., Punches, Brittany E., Swor, Robert A., McGrath, Meghan E., Hudak, Lauren A., Pascual, Jose L., Seamon, Mark J., Datner, Elizabeth M., Pearson, Claire, Peak, David A., Merchant, Roland C., Domeier, Robert M., Rathlev, Niels K., O'Neil, Brian J., Sergot, Paulina, Sanchez, Leon D., Bruce, Steven E., Pietrzak, Robert H., Joormann, Jutta, Barch, Deanna M., Pizzagalli, Diego A., Sheridan, John F., Smoller, Jordan W., Harte, Steven E., Elliott, James M., Kessler, Ronald C., Koenen, Karestan C., and Jovanovic, Tanja

Published
2022
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29. Quantitative Assessment of Non-Pelvic Pressure Pain Sensitivity in Urological Chronic Pelvic Pain Syndrome

Author

Harte, Steven E, Schrepf, Andrew, Gallop, Robert, Kruger, Grant H, Lai, Hing Hung Henry, Sutcliffe, Siobhan, Halvorson, Megan, Ichesco, Eric, Naliboff, Bruce D, Afari, Niloofar, Harris, Richard E, Farrar, John T, Tu, Frank, Landis, John Richard, and Clauw, Daniel J

Subjects
Clinical Research, Pain Research, Chronic Pain, Neurosciences, Urologic Diseases, Musculoskeletal, Adult, Chronic Disease, Cystitis, Interstitial, Female, Humans, Irritable Bowel Syndrome, Male, Middle Aged, Pain Threshold, Pelvic Pain, Prostatitis, Quantitative sensory testing, Pressure pain threshold, Interstitial cystitis, Bladder pain syndrome, Chronic prostatitis, Chronic pelvic pain syndrome, Central sensitization, MAPP Research Network, Medical and Health Sciences, Psychology and Cognitive Sciences, Anesthesiology
Abstract

Experimental pain sensitivity was assessed in individuals with urologic chronic pelvic pain syndrome (UCPPS) as part of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. A series of computer-controlled pressure stimuli were delivered to the thumbnail bed, an asymptomatic site distant from the area of UCPPS pain that is considered to be indicative of overall body pain threshold. Stimuli were rated according to a standardized magnitude estimation protocol. Pain sensitivity in participants with UCPPS was compared with healthy controls and a mixed pain group composed of individuals with other chronic overlapping pain conditions, including fibromyalgia, chronic fatigue, and irritable bowel syndromes. Data from 6 participating MAPP testing sites were pooled for analysis. Participants with UCPPS (n = 153) exhibited an intermediate pain sensitivity phenotype: they were less sensitive relative to the mixed pain group (n = 35) but significantly more sensitive than healthy controls (n = 100). Increased pain sensitivity in patients with UCPPS was associated with both higher levels of clinical pain severity and more painful body areas outside the pelvic region. Exploratory analyses in participants with UCPPS revealed that pain sensitivity increased during periods of urologic symptom flare and that less pressure pain sensitivity at baseline was associated with a greater likelihood of subsequent genitourinary pain improvement 1 year later. The finding that individuals with UCPPS demonstrate nonpelvic pain hypersensitivity that is related to clinical symptoms suggests that central nervous system mechanisms of pain amplification contribute to UCPPS.

Published
2019

30. Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network

Author

Clemens, J Quentin, Mullins, Chris, Ackerman, A Lenore, Bavendam, Tamara, van Bokhoven, Adrie, Ellingson, Benjamin M, Harte, Steven E, Kutch, Jason J, Lai, H Henry, Martucci, Katherine T, Moldwin, Robert, Naliboff, Bruce D, Pontari, Michel A, Sutcliffe, Siobhan, and Landis, J Richard

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Urologic Diseases, Pain Research, Clinical Research, Chronic Pain, Renal and urogenital, Biomedical Research, Cystitis, Interstitial, Humans, Interdisciplinary Research, Male, Pelvic Pain, Prostatitis, Syndrome, MAPP Research Network Study Group, Urology & Nephrology, Clinical sciences
Abstract

Urologic chronic pelvic pain syndrome (UCPPS), which encompasses interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, is characterized by chronic pain in the pelvic region or genitalia that is often accompanied by urinary frequency and urgency. Despite considerable research, no definite aetiological risk factors or effective treatments have been identified. The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network uses a novel integrated strategy to characterize UCPPS as a systemic disorder that potentially involves multiple aetiologies. The first phase, MAPP I, included >1,000 participants who completed an intensive baseline assessment followed by a 12-month observational follow-up period. MAPP I studies showed that UCPPS pain and urinary symptoms co-vary, with only moderate correlation, and should be evaluated separately and that symptom flares are common and can differ considerably in intensity, duration and influence on quality of life. Longitudinal clinical changes in UCPPS correlated with structural and functional brain changes, and many patients experienced global multisensory hypersensitivity. Additionally, UCPPS symptom profiles were distinguishable by biological correlates, such as immune factors. These findings indicate that patients with UCPPS have objective phenotypic abnormalities and distinct biological characteristics, providing a new foundation for the study and clinical management of UCPPS.

Published
2019

31. Structural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis

Author

Harnett, Nathaniel G., Finegold, Katherine E., Lebois, Lauren A. M., van Rooij, Sanne J. H., Ely, Timothy D., Murty, Vishnu P., Jovanovic, Tanja, Bruce, Steven E., House, Stacey L., Beaudoin, Francesca L., An, Xinming, Zeng, Donglin, Neylan, Thomas C., Clifford, Gari D., Linnstaedt, Sarah D., Germine, Laura T., Bollen, Kenneth A., Rauch, Scott L., Haran, John P., Storrow, Alan B., Lewandowski, Christopher, Musey, Paul I., Hendry, Phyllis L., Sheikh, Sophia, Jones, Christopher W., Punches, Brittany E., Kurz, Michael C., Swor, Robert A., Hudak, Lauren A., Pascual, Jose L., Seamon, Mark J., Harris, Erica, Chang, Anna M., Pearson, Claire, Peak, David A., Domeier, Robert M., Rathlev, Niels K., O’Neil, Brian J., Sergot, Paulina, Sanchez, Leon D., Miller, Mark W., Pietrzak, Robert H., Joormann, Jutta, Barch, Deanna M., Pizzagalli, Diego A., Sheridan, John F., Harte, Steven E., Elliott, James M., Kessler, Ronald C., Koenen, Karestan C., McLean, Samuel A., Nickerson, Lisa D., Ressler, Kerry J., and Stevens, Jennifer S.

Published
2022
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32. Sensory sensitivity and symptom severity represent unique dimensions of chronic pain

Author

Schrepf, Andrew, Williams, David A, Gallop, Robert, Naliboff, Bruce D, Basu, Neil, Kaplan, Chelsea, Harper, Daniel E, Landis, J Richard, Clemens, J Quentin, Strachan, Eric, Griffith, James W, Afari, Niloofar, Hassett, Afton, Pontari, Michel A, Clauw, Daniel J, and Harte, Steven E

Subjects
Neurosciences, Chronic Pain, Clinical Research, Urologic Diseases, Peripheral Neuropathy, Pain Research, Neurological, Adult, Biomedical Research, Cohort Studies, Connectome, Factor Analysis, Statistical, Female, Humans, Interdisciplinary Communication, Male, National Institute of Diabetes and Digestive and Kidney Diseases (U.S.), Pelvic Pain, United States, Interstitial cystitis/painful bladder syndrome, Factor analysis, statistical, Fibromyalgia, Central nervous system sensitization, Interoception, MAPP Research Network, Medical and Health Sciences, Psychology and Cognitive Sciences, Anesthesiology
Abstract

Chronic overlapping pain conditions (COPCs) are characterized by aberrant central nervous system processing of pain. This "centralized pain" phenotype has been described using a large and diverse set of symptom domains, including the spatial distribution of pain, pain intensity, fatigue, mood imbalances, cognitive dysfunction, altered somatic sensations, and hypersensitivity to external stimuli. Here, we used 3 cohorts, including patients with urologic chronic pelvic pain syndrome, a mixed pain cohort with other COPCs, and healthy individuals (total n = 1039) from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network to explore the factor structure of symptoms of centralized pain. Using exploratory and confirmatory factor analysis, we identified 2 general factors in all 3 cohorts, one characterized by a broad increased sensitivity to internal somatic sensations,environmental stimuli, and diffuse pain, termed Generalized Sensory Sensitivity, and one characterized by constitutional symptoms-Sleep, Pain, Affect, Cognition, Energy (SPACE). Longitudinal analyses in the urologic chronic pelvic pain syndrome cohort found the same 2-factor structure at month 6 and 1 year, suggesting that the 2-factor structure is reproducible over time. In secondary analyses, we found that Generalized Sensory Sensitivity particularly is associated with the presence of comorbid COPCs, whereas SPACE shows modest associations with measures of disability and urinary symptoms. These factors may represent an important and distinct continuum of symptoms that are indicative of the centralized pain phenotype at high levels. Future research of COPCs should accommodate the measurement of each factor.

Published
2018

33. Stimulated whole-blood cytokine/chemokine responses are associated with interstitial cystitis/bladder pain syndrome phenotypes and features of nociplastic pain: a multidisciplinary approach to the study of chronic pelvic pain research network study

Author

Schrepf, Andrew, Kaplan, Chelsea, Harris, Richard E., Williams, David A., Clauw, Daniel J., As-Sanie, Sawsan, Till, Sara, Clemens, J. Quentin, Rodriguez, Larissa V., Van Bokhoven, Adrie, Landis, Richard, Gallop, Robert, Bradley, Catherine, Naliboff, Bruce, Pontari, Mike, OʼDonnell, Michael, Luo, Yi, Kreder, Karl, Lutgendorf, Susan K., and Harte, Steven E.

Published
2022
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34. Sex-dependent differences in vulnerability to early risk factors for posttraumatic stress disorder: results from the AURORA study

Author

Haering, Stephanie, primary, Seligowski, Antonia V., additional, Linnstaedt, Sarah D., additional, Michopoulos, Vasiliki, additional, House, Stacey L., additional, Beaudoin, Francesca L., additional, An, Xinming, additional, Neylan, Thomas C., additional, Clifford, Gari D., additional, Germine, Laura T., additional, Rauch, Scott L., additional, Haran, John P., additional, Storrow, Alan B., additional, Lewandowski, Christopher, additional, Musey, Paul I., additional, Hendry, Phyllis L., additional, Sheikh, Sophia, additional, Jones, Christopher W., additional, Punches, Brittany E., additional, Swor, Robert A., additional, Gentile, Nina T., additional, Hudak, Lauren A., additional, Pascual, Jose L., additional, Seamon, Mark J., additional, Pearson, Claire, additional, Peak, David A., additional, Merchant, Roland C., additional, Domeier, Robert M., additional, Rathlev, Niels K., additional, O'Neil, Brian J., additional, Sanchez, Leon D., additional, Bruce, Steven E., additional, Harte, Steven E., additional, McLean, Samuel A., additional, Kessler, Ronald C., additional, Koenen, Karestan C., additional, Stevens, Jennifer S., additional, and Powers, Abigail, additional

Published
2024
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38. Post-traumatic stress and future substance use outcomes: leveraging antecedent factors to stratify risk

Author

Garrison-Desany, Henri M., primary, Meyers, Jacquelyn L., additional, Linnstaedt, Sarah D., additional, House, Stacey L., additional, Beaudoin, Francesca L., additional, An, Xinming, additional, Zeng, Donglin, additional, Neylan, Thomas C., additional, Clifford, Gari D., additional, Jovanovic, Tanja, additional, Germine, Laura T., additional, Bollen, Kenneth A., additional, Rauch, Scott L., additional, Haran, John P., additional, Storrow, Alan B., additional, Lewandowski, Christopher, additional, Musey, Paul I., additional, Hendry, Phyllis L., additional, Sheikh, Sophia, additional, Jones, Christopher W., additional, Punches, Brittany E., additional, Swor, Robert A., additional, Gentile, Nina T., additional, Hudak, Lauren A., additional, Pascual, Jose L., additional, Seamon, Mark J., additional, Harris, Erica, additional, Pearson, Claire, additional, Peak, David A., additional, Domeier, Robert M., additional, Rathlev, Niels K., additional, O’Neil, Brian J., additional, Sergot, Paulina, additional, Sanchez, Leon D., additional, Bruce, Steven E., additional, Joormann, Jutta, additional, Harte, Steven E., additional, McLean, Samuel A., additional, Koenen, Karestan C., additional, and Denckla, Christy A., additional

Published
2024
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39. Sex differences in response inhibition-related neural predictors of PTSD in recent trauma-exposed civilians

Author

Borst, Bibian, primary, Jovanovic, Tanja, additional, House, Stacey L., additional, Bruce, Steven E., additional, Harnett, Nathaniel G., additional, Roeckner, Alyssa R., additional, Ely, Timothy D., additional, Lebois, Lauren A.M., additional, Young, Dmitri, additional, Beaudoin, Francesca L., additional, An, Xinming, additional, Neylan, Thomas C., additional, Clifford, Gari D., additional, Linnstaedt, Sarah D., additional, Germine, Laura T., additional, Bollen, Kenneth A., additional, Rauch, Scott L., additional, Haran, John P., additional, Storrow, Alan B., additional, Lewandowski, Christopher, additional, Musey, Paul I., additional, Hendry, Phyllis L., additional, Sheikh, Sophia, additional, Jones, Christopher W., additional, Punches, Brittany E., additional, Hudak, Lauren A., additional, Pascual, Jose L., additional, Seamon, Mark J., additional, Datner, Elizabeth M., additional, Pearson, Claire, additional, Peak, David A., additional, Domeier, Robert M., additional, Rathlev, Niels K., additional, O'Neil, Brian J., additional, Sergot, Paulina, additional, Sanchez, Leon D., additional, Harte, Steven E., additional, Koenen, Karestan C., additional, Kessler, Ronald C., additional, McLean, Samuel A., additional, Ressler, Kerry J., additional, Stevens, Jennifer S., additional, and van Rooij, Sanne J.H., additional

Published
2024
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43. Socio-demographic and trauma-related predictors of PTSD within 8 weeks of a motor vehicle collision in the AURORA study

Author

Kessler, Ronald C., Ressler, Kerry J., House, Stacey L., Beaudoin, Francesca L., An, Xinming, Stevens, Jennifer S., Zeng, Donglin, Neylan, Thomas C., Linnstaedt, Sarah D., Germine, Laura T., Musey, Jr., Paul I., Hendry, Phyllis L., Sheikh, Sophia, Storrow, Alan B., Jones, Christopher W., Punches, Brittany E., Datner, Elizabeth M., Mohiuddin, Kamran, Gentile, Nina T., McGrath, Meghan E., van Rooij, Sanne J., Hudak, Lauren A., Haran, John P., Peak, David A., Domeier, Robert M., Pearson, Claire, Sanchez, Leon D., Rathlev, Niels K., Peacock, William F., Bruce, Steven E., Miller, Mark W., Joormann, Jutta, Barch, Deanna M., Pizzagalli, Diego A., Sheridan, John F., Smoller, Jordan W., Pace, Thaddeus W. W., Harte, Steven E., Elliott, James M., Harnett, Nathaniel G., Lebois, Lauren A. M., Hwang, Irving, Sampson, Nancy A., Koenen, Karestan C., and McLean, Samuel A.

Published
2021
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44. Prognostic neuroimaging biomarkers of trauma-related psychopathology: resting-state fMRI shortly after trauma predicts future PTSD and depression symptoms in the AURORA study

Author

Harnett, Nathaniel G., van Rooij, Sanne J. H., Ely, Timothy D., Lebois, Lauren A. M., Murty, Vishnu P., Jovanovic, Tanja, Hill, Sarah B., Dumornay, Nathalie M., Merker, Julia B., Bruce, Steve E., House, Stacey L., Beaudoin, Francesca L., An, Xinming, Zeng, Donglin, Neylan, Thomas C., Clifford, Gari D., Linnstaedt, Sarah D., Germine, Laura T., Bollen, Kenneth A., Rauch, Scott L., Lewandowski, Christopher, Hendry, Phyllis L., Sheikh, Sophia, Storrow, Alan B., Musey, Jr., Paul I., Haran, John P., Jones, Christopher W., Punches, Brittany E., Swor, Robert A., McGrath, Meghan E., Pascual, Jose L., Seamon, Mark J., Mohiuddin, Kamran, Chang, Anna M., Pearson, Claire, Peak, David A., Domeier, Robert M., Rathlev, Niels K., Sanchez, Leon D., Pietrzak, Robert H., Joormann, Jutta, Barch, Deanna M., Pizzagalli, Diego A., Sheridan, John F., Harte, Steven E., Elliott, James M., Kessler, Ronald C., Koenen, Karestan C., Mclean, Samuel, Ressler, Kerry J., and Stevens, Jennifer S.

Published
2021
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48. Inflammation and autoimmunity are interrelated in patients with sickle cell disease at a steady-state condition: implications for vaso-occlusive crisis, pain, and sensory sensitivity

Author

Li, Wei, primary, Pucka, Andrew Q., additional, Debats, Candice, additional, Reyes, Brandon A., additional, Syed, Fahim, additional, O’Brien, Andrew R.W., additional, Mehta, Rakesh, additional, Manchanda, Naveen, additional, Jacob, Seethal A., additional, Hardesty, Brandon M., additional, Greist, Anne, additional, Harte, Steven E., additional, Harris, Richard E., additional, Yu, Qigui, additional, and Wang, Ying, additional

Published
2024
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50. Reply By Authors

Author

Mawla, Ishtiaq, primary, Schrepf, Andrew, additional, Kutch, Jason J., additional, Helmuth, Margaret E., additional, Smith, Abigail R., additional, Ichesco, Eric, additional, Yang, Claire C., additional, Andreev, Victor P., additional, Kreder, Karl J., additional, Bradley, Catherine S., additional, Magnotta, Vincent A., additional, Kirkali, Ziya, additional, Harris, Richard E., additional, Lai, H. Henry, additional, and Harte, Steven E., additional

Published
2024
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