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1. Slaapdeprivatie in de vroege tienerjaren als voorspeller voor psychosociale problemen op 15- tot 16-jarige leeftijd bij Nederlandse jongeren

Author: van Ham-Borawitz, Veronique E. J., Harskamp- van Ginkel, Margreet W., Vrijkotte, Tanja G. M., and de Rooij, Susanne R.
Published: 2023
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2. Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis

Author: Eijkemans, Marianne, Mommers, Monique, Harskamp-van Ginkel, Margreet W., Vrijkotte, Tanja G.M., Ludvigsson, Johnny, Faresjö, Åshild, Bergström, Anna, Ekström, Sandra, Grote, Veit, Koletzko, Berthold, Bønnelykke, Klaus, Eliasen, Anders Ulrik, Bager, Peter, Melbye, Mads, Annesi-Maesano, Isabella, Baïz, Nour, Barros, Henrique, Santos, Ana Cristina, Duijts, Liesbeth, Mensink-Bout, Sara M., Flexeder, Claudia, Koletzko, Sibylle, Schikowski, Tamara, Eggesbø, Merete Åse, Lenters, Virissa, Fernández-Tardón, Guillermo, Subiza-Perez, Mikel, Garcia-Aymerich, Judith, López-Vicente, Mónica, Sunyer, Jordi, Torrent, Maties, Ballester, Ferran, Kelleher, Cecily, Mehegan, John, Berg, Andrea von, Herberth, Gunda, Standl, Marie, Kuehni, Claudia E., Pedersen, Eva S.L., Jansen, Maria, Gehring, Ulrike, Boer, Jolanda M.A., Devereux, Graham, Turner, Steve, Peltola, Ville, Lagström, Hanna, Inskip, Hazel M., Pike, Katharine C., Dalmeijer, Geertje W., Ent, Cornelis K.van der, Thijs, Carel, Eijkemans, Marianne, Mommers, Monique, Harskamp-van Ginkel, Margreet W., Vrijkotte, Tanja G.M., Ludvigsson, Johnny, Faresjö, Åshild, Bergström, Anna, Ekström, Sandra, Grote, Veit, Koletzko, Berthold, Bønnelykke, Klaus, Eliasen, Anders Ulrik, Bager, Peter, Melbye, Mads, Annesi-Maesano, Isabella, Baïz, Nour, Barros, Henrique, Santos, Ana Cristina, Duijts, Liesbeth, Mensink-Bout, Sara M., Flexeder, Claudia, Koletzko, Sibylle, Schikowski, Tamara, Eggesbø, Merete Åse, Lenters, Virissa, Fernández-Tardón, Guillermo, Subiza-Perez, Mikel, Garcia-Aymerich, Judith, López-Vicente, Mónica, Sunyer, Jordi, Torrent, Maties, Ballester, Ferran, Kelleher, Cecily, Mehegan, John, Berg, Andrea von, Herberth, Gunda, Standl, Marie, Kuehni, Claudia E., Pedersen, Eva S.L., Jansen, Maria, Gehring, Ulrike, Boer, Jolanda M.A., Devereux, Graham, Turner, Steve, Peltola, Ville, Lagström, Hanna, Inskip, Hazel M., Pike, Katharine C., Dalmeijer, Geertje W., Ent, Cornelis K.van der, and Thijs, Carel
Abstract: OBJECTIVES: To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study. DESIGN: Pooling of longitudinal data from collaborating birth cohorts using meta-analysis of separate cohort-specific estimates and analysis of individual participant data of all cohorts combined. SETTING: Children aged 0-18 years from 26 European birth cohorts. PARTICIPANTS: 136 071 individual children from 26 cohorts, with information on PA and/or sedentary behaviour in early childhood and asthma assessment in later childhood. MAIN OUTCOME MEASURE: Questionnaire-based current asthma and lung function measured by spirometry (forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity) at age 6-18 years. RESULTS: Questionnaire-based and accelerometry-based PA and sedentary behaviour at age 3-5 years was not associated with asthma at age 6-18 years (PA in hours/day adjusted OR 1.01, 95% CI 0.98 to 1.04; sedentary behaviour in hours/day adjusted OR 1.03, 95% CI 0.99 to 1.07). PA was not associated with lung function at any age. Analyses of sedentary behaviour and lung function showed inconsistent results. CONCLUSIONS: Reduced PA and increased sedentary behaviour before 6 years of age were not associated with the presence of asthma later in childhood.
Published: 2024

3. Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis

Author: Global Health, Longziekten patientenzorg, Speerpunt Child Health, Child Health, Infection & Immunity, Eijkemans, Marianne, Mommers, Monique, Harskamp-van Ginkel, Margreet W., Vrijkotte, Tanja G.M., Ludvigsson, Johnny, Faresjö, Åshild, Bergström, Anna, Ekström, Sandra, Grote, Veit, Koletzko, Berthold, Bønnelykke, Klaus, Eliasen, Anders Ulrik, Bager, Peter, Melbye, Mads, Annesi-Maesano, Isabella, Baïz, Nour, Barros, Henrique, Santos, Ana Cristina, Duijts, Liesbeth, Mensink-Bout, Sara M., Flexeder, Claudia, Koletzko, Sibylle, Schikowski, Tamara, Eggesbø, Merete Åse, Lenters, Virissa, Fernández-Tardón, Guillermo, Subiza-Perez, Mikel, Garcia-Aymerich, Judith, López-Vicente, Mónica, Sunyer, Jordi, Torrent, Maties, Ballester, Ferran, Kelleher, Cecily, Mehegan, John, Berg, Andrea von, Herberth, Gunda, Standl, Marie, Kuehni, Claudia E., Pedersen, Eva S.L., Jansen, Maria, Gehring, Ulrike, Boer, Jolanda M.A., Devereux, Graham, Turner, Steve, Peltola, Ville, Lagström, Hanna, Inskip, Hazel M., Pike, Katharine C., Dalmeijer, Geertje W., Ent, Cornelis K.van der, Thijs, Carel, Global Health, Longziekten patientenzorg, Speerpunt Child Health, Child Health, Infection & Immunity, Eijkemans, Marianne, Mommers, Monique, Harskamp-van Ginkel, Margreet W., Vrijkotte, Tanja G.M., Ludvigsson, Johnny, Faresjö, Åshild, Bergström, Anna, Ekström, Sandra, Grote, Veit, Koletzko, Berthold, Bønnelykke, Klaus, Eliasen, Anders Ulrik, Bager, Peter, Melbye, Mads, Annesi-Maesano, Isabella, Baïz, Nour, Barros, Henrique, Santos, Ana Cristina, Duijts, Liesbeth, Mensink-Bout, Sara M., Flexeder, Claudia, Koletzko, Sibylle, Schikowski, Tamara, Eggesbø, Merete Åse, Lenters, Virissa, Fernández-Tardón, Guillermo, Subiza-Perez, Mikel, Garcia-Aymerich, Judith, López-Vicente, Mónica, Sunyer, Jordi, Torrent, Maties, Ballester, Ferran, Kelleher, Cecily, Mehegan, John, Berg, Andrea von, Herberth, Gunda, Standl, Marie, Kuehni, Claudia E., Pedersen, Eva S.L., Jansen, Maria, Gehring, Ulrike, Boer, Jolanda M.A., Devereux, Graham, Turner, Steve, Peltola, Ville, Lagström, Hanna, Inskip, Hazel M., Pike, Katharine C., Dalmeijer, Geertje W., Ent, Cornelis K.van der, and Thijs, Carel
Published: 2024

4. Physical activity, sedentary behaviour, and childhood asthma:a European collaborative analysis

Author: Eijkemans, Marianne, Mommers, Monique, Harskamp-van Ginkel, Margreet W., Vrijkotte, Tanja G.M., Ludvigsson, Johnny, Faresjö, Åshild, Bergström, Anna, Ekström, Sandra, Grote, Veit, Koletzko, Berthold, Bønnelykke, Klaus, Eliasen, Anders Ulrik, Bager, Peter, Melbye, Mads, Annesi-Maesano, Isabella, Baïz, Nour, Barros, Henrique, Santos, Ana Cristina, Duijts, Liesbeth, Mensink-Bout, Sara M., Flexeder, Claudia, Koletzko, Sibylle, Schikowski, Tamara, Eggesbø, Merete Åse, Lenters, Virissa, Fernández-Tardón, Guillermo, Subiza-Perez, Mikel, Garcia-Aymerich, Judith, López-Vicente, Mónica, Sunyer, Jordi, Torrent, Maties, Ballester, Ferran, Kelleher, Cecily, Mehegan, John, Berg, Andrea von, Herberth, Gunda, Standl, Marie, Kuehni, Claudia E., Pedersen, Eva S.L., Jansen, Maria, Gehring, Ulrike, Boer, Jolanda M.A., Devereux, Graham, Turner, Steve, Peltola, Ville, Lagström, Hanna, Inskip, Hazel M., Pike, Katharine C., Dalmeijer, Geertje W., Ent, Cornelis K.van der, Thijs, Carel, Eijkemans, Marianne, Mommers, Monique, Harskamp-van Ginkel, Margreet W., Vrijkotte, Tanja G.M., Ludvigsson, Johnny, Faresjö, Åshild, Bergström, Anna, Ekström, Sandra, Grote, Veit, Koletzko, Berthold, Bønnelykke, Klaus, Eliasen, Anders Ulrik, Bager, Peter, Melbye, Mads, Annesi-Maesano, Isabella, Baïz, Nour, Barros, Henrique, Santos, Ana Cristina, Duijts, Liesbeth, Mensink-Bout, Sara M., Flexeder, Claudia, Koletzko, Sibylle, Schikowski, Tamara, Eggesbø, Merete Åse, Lenters, Virissa, Fernández-Tardón, Guillermo, Subiza-Perez, Mikel, Garcia-Aymerich, Judith, López-Vicente, Mónica, Sunyer, Jordi, Torrent, Maties, Ballester, Ferran, Kelleher, Cecily, Mehegan, John, Berg, Andrea von, Herberth, Gunda, Standl, Marie, Kuehni, Claudia E., Pedersen, Eva S.L., Jansen, Maria, Gehring, Ulrike, Boer, Jolanda M.A., Devereux, Graham, Turner, Steve, Peltola, Ville, Lagström, Hanna, Inskip, Hazel M., Pike, Katharine C., Dalmeijer, Geertje W., Ent, Cornelis K.van der, and Thijs, Carel
Abstract: OBJECTIVES: To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study. DESIGN: Pooling of longitudinal data from collaborating birth cohorts using meta-analysis of separate cohort-specific estimates and analysis of individual participant data of all cohorts combined. SETTING: Children aged 0-18 years from 26 European birth cohorts. PARTICIPANTS: 136 071 individual children from 26 cohorts, with information on PA and/or sedentary behaviour in early childhood and asthma assessment in later childhood. MAIN OUTCOME MEASURE: Questionnaire-based current asthma and lung function measured by spirometry (forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity) at age 6-18 years. RESULTS: Questionnaire-based and accelerometry-based PA and sedentary behaviour at age 3-5 years was not associated with asthma at age 6-18 years (PA in hours/day adjusted OR 1.01, 95% CI 0.98 to 1.04; sedentary behaviour in hours/day adjusted OR 1.03, 95% CI 0.99 to 1.07). PA was not associated with lung function at any age. Analyses of sedentary behaviour and lung function showed inconsistent results. CONCLUSIONS: Reduced PA and increased sedentary behaviour before 6 years of age were not associated with the presence of asthma later in childhood.
Published: 2024

5. Potential determinants during ‘the first 1000 days of life’ of sleep problems in school-aged children

Author: Harskamp-van Ginkel, Margreet W., Kool, Ruth E., van Houtum, Lieke, Belmon, Laura S., Huss, Anke, Chinapaw, Mai J.M., and Vrijkotte, Tanja G.M.
Published: 2020
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6. The cross-sectional association of parental psychosocial status with children's Body Mass Index z-score and the mediating role of children's energy balance behaviors - the ABCD Study.

Author: Overman, Meredith L., Vrijkotte, Tanja, Sánchez Castro, Yolanda M., Harskamp-van Ginkel, Margreet W., Hunsberger, Monica, Renders, Carry M., Kremers, Stef P. J., and Chinapaw, Mai J. M.
Subjects: BODY mass index, SCREEN time, BEDTIME, CHILD development, SPORTS participation
Abstract: Objective: Investigate the cross-sectional association between the psychosocial status of mothers and fathers and the BMI z-scores of their 10 to 12-year-old children. Explore whether this association is mediated by children's diet, physical activity, screen time and sleep. Analyze the moderating effect of the educational levels of both the mother and father on the association. Design: In a cross-sectional study design, children's height and weight were measured following a standardized protocol. Parents completed the validated Depression Anxiety and Stress questionnaire, while diet quality, sports participation, time spent in bed and screen time were assessed through child-report using previously validated questions. Participants: The data for this study were obtained from the Amsterdam Born Children and their Development study, involving children aged 10 to 12 years and both of their parents (N = 1315). Results: The majority, 80%, of the parents were highly educated and born in the Netherlands, and 68% of the children had a healthy BMI. Maternal or paternal psychosocial status was not significantly associated with children's BMI z-score (maternal β -0.0037; 95% CI: -0.008 to 0.0007, paternal β 0.0028; 95% CI: -0.007 to 0.002). Screen time mediated the association between paternal psychosocial status and children's BMI z-score (β = 0.010, 95% CI: 0.002; 0.020). Children's diet, physical activity, and sleep did not mediate the association between paternal psychosocial status and children's BMI z-score. Parental educational level was not a moderator. Conclusions: This research is unique in including four energy balance behaviors and including both mothers and fathers' psychosocial status. Children withfathers experiencing poorer psychosocial status engaged in more screen time which partly explained their higher BMI z-score. [ABSTRACT FROM AUTHOR]
Published: 2024
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7. Differences in birth weight between immigrants’ and natives’ children in Europe and Australia: a LifeCycle comparative observational cohort study

Author: Florian, Sandra, primary, Ichou, Mathieu, additional, Panico, Lidia, additional, Pinel-Jacquemin, Stéphanie, additional, Vrijkotte, Tanja G M, additional, Harskamp-van Ginkel, Margreet W, additional, Huang, Rae-Chi, additional, Carson, Jennie, additional, Rodriguez, Loreto Santa Marina, additional, Subiza-Pérez, Mikel, additional, Vrijheid, Martine, additional, Fernández-Barrés, Sílvia, additional, Yang, Tiffany C, additional, Wright, John, additional, Corpeleijn, Eva, additional, Cardol, Marloes, additional, Isaevska, Elena, additional, Moccia, Chiara, additional, Kooijman, Marjolein N, additional, Voerman, Ellis, additional, Jaddoe, Vincent, additional, Welten, Marieke, additional, Spada, Elena, additional, Rebagliato, Marisa, additional, Beneito, Andrea, additional, Ronfani, Luca, additional, and Charles, Marie-Aline, additional
Published: 2023
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8. Long-term cardiometabolic health in people born after assisted reproductive technology:a multi-cohort analysis

Author: Elhakeem, Ahmed, Taylor, Amy E., Inskip, Hazel M., Huang, Jonathan Y., Mansell, Toby, Rodrigues, Carina, Asta, Federica, Blaauwendraad, Sophia M., Håberg, Siri E., Halliday, Jane, Harskamp-van Ginkel, Margreet W., He, Jian Rong, Jaddoe, Vincent W.V., Lewis, Sharon, Maher, Gillian M., Manios, Yannis, McCarthy, Fergus P., Reiss, Irwin K.M., Rusconi, Franca, Salika, Theodosia, Tafflet, Muriel, Qiu, Xiu, Åsvold, Bjørn O., Burgner, David, Chan, Jerry K.Y., Gagliardi, Luigi, Gaillard, Romy, Heude, Barbara, Magnus, Maria C., Moschonis, George, Murray, Deirdre, Nelson, Scott M., Porta, Daniela, Saffery, Richard, Barros, Henrique, Eriksson, Johan G., Vrijkotte, Tanja G.M., Lawlor, Deborah A., Elhakeem, Ahmed, Taylor, Amy E., Inskip, Hazel M., Huang, Jonathan Y., Mansell, Toby, Rodrigues, Carina, Asta, Federica, Blaauwendraad, Sophia M., Håberg, Siri E., Halliday, Jane, Harskamp-van Ginkel, Margreet W., He, Jian Rong, Jaddoe, Vincent W.V., Lewis, Sharon, Maher, Gillian M., Manios, Yannis, McCarthy, Fergus P., Reiss, Irwin K.M., Rusconi, Franca, Salika, Theodosia, Tafflet, Muriel, Qiu, Xiu, Åsvold, Bjørn O., Burgner, David, Chan, Jerry K.Y., Gagliardi, Luigi, Gaillard, Romy, Heude, Barbara, Magnus, Maria C., Moschonis, George, Murray, Deirdre, Nelson, Scott M., Porta, Daniela, Saffery, Richard, Barros, Henrique, Eriksson, Johan G., Vrijkotte, Tanja G.M., and Lawlor, Deborah A.
Abstract: Aims To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age Methods Differences in systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), lipids, and hyperglycaemic/insulin resistance and results markers were examined using multiple linear regression models in 14 population-based birth cohorts in Europe, Australia, and Singapore, and results were combined using meta-analysis. Change in cardiometabolic outcomes from 2 to 26 years was examined using trajectory modelling of four cohorts with repeated measures. 35 938 (654 ART) offspring were included in the meta-analysis. Mean age ranged from 13 months to 27.4 years but was <10 years in 11/14 cohorts. Meta-analysis found no statistical difference (ART minus NC) in SBP (−0.53 mmHg; 95% CI:−1.59 to 0.53), DBP (−0.24 mmHg; −0.83 to 0.35), or HR (0.02 beat/min; −0.91 to 0.94). Total cholesterol (2.59%; 0.10–5.07), HDL cholesterol (4.16%; 2.52–5.81), LDL cholesterol (4.95%; 0.47–9.43) were statistically significantly higher in ART-conceived vs. NC offspring. No statistical difference was seen for triglycerides (TG), glucose, insulin, and glycated haemoglobin. Long-term follow-up of 17 244 (244 ART) births identified statistically significant associations between ART and lower predicted SBP/DBP in childhood, and subtle trajectories to higher SBP and TG in young adulthood; however, most differences were not statistically significant Conclusion These findings of small and statistically non-significant differences in offspring cardiometabolic outcomes should reassure people receiving ART. Longer-term follow-up is warranted to investigate changes over adulthood in the risks of hypertension, dyslipidaemia, and preclinical and clinical cardiovascular disease.
Published: 2023

9. Differences in birth weight between immigrants' and natives' children in Europe and Australia:a LifeCycle comparative observational cohort study

Author: Florian, Sandra, Ichou, Mathieu, Panico, Lidia, Pinel-Jacquemin, Stéphanie, Vrijkotte, Tanja G.M., Harskamp-van Ginkel, Margreet W., Huang, Rae Chi, Carson, Jennie, Rodriguez, Loreto Santa Marina, Subiza-Pérez, Mikel, Vrijheid, Martine, Fernández-Barrés, Sílvia, Yang, Tiffany C., Wright, John, Corpeleijn, Eva, Cardol, Marloes, Isaevska, Elena, Moccia, Chiara, Kooijman, Marjolein N., Voerman, Ellis, Jaddoe, Vincent, Welten, Marieke, Spada, Elena, Rebagliato, Marisa, Beneito, Andrea, Ronfani, Luca, Charles, Marie Aline, Florian, Sandra, Ichou, Mathieu, Panico, Lidia, Pinel-Jacquemin, Stéphanie, Vrijkotte, Tanja G.M., Harskamp-van Ginkel, Margreet W., Huang, Rae Chi, Carson, Jennie, Rodriguez, Loreto Santa Marina, Subiza-Pérez, Mikel, Vrijheid, Martine, Fernández-Barrés, Sílvia, Yang, Tiffany C., Wright, John, Corpeleijn, Eva, Cardol, Marloes, Isaevska, Elena, Moccia, Chiara, Kooijman, Marjolein N., Voerman, Ellis, Jaddoe, Vincent, Welten, Marieke, Spada, Elena, Rebagliato, Marisa, Beneito, Andrea, Ronfani, Luca, and Charles, Marie Aline
Abstract: OBJECTIVE: Research on adults has identified an immigrant health advantage, known as the 'immigrant health paradox', by which migrants exhibit better health outcomes than natives. Is this health advantage transferred from parents to children in the form of higher birth weight relative to children of natives? SETTING: Western Europe and Australia. PARTICIPANTS: We use data from nine birth cohorts participating in the LifeCycle Project, including five studies with large samples of immigrants' children: Etude Longitudinale Française depuis l'Enfance-France (N=12 494), the Raine Study-Australia (N=2283), Born in Bradford-UK (N=4132), Amsterdam Born Children and their Development study-Netherlands (N=4030) and the Generation R study-Netherlands (N=4877). We include male and female babies born to immigrant and native parents. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome is birth weight measured in grams. Different specifications were tested: birth weight as a continuous variable including all births (DV1), the same variable but excluding babies born with over 4500 g (DV2), low birth weight as a 0-1 binary variable (1=birth weight below 2500 g) (DV3). Results using these three measures were similar, only results using DV1 are presented. Parental migration status is measured in four categories: both parents natives, both born abroad, only mother born abroad and only father born abroad. RESULTS: Two patterns in children's birth weight by parental migration status emerged: higher birth weight among children of immigrants in France (+12 g, p<0.10) and Australia (+40 g, p<0.10) and lower birth weight among children of immigrants in the UK (-82 g, p<0.05) and the Netherlands (-80 g and -73 g, p<0.001) compared with natives' children. Smoking during pregnancy emerged as a mechanism explaining some of the birth weight gaps between children of immigrants and natives. CONCLUSION: The immigrant health advantage is not universally transferred to children
Published: 2023

10. Differences in birth weight between immigrants' and natives' children in Europe and Australia: A LifeCycle comparative observational cohort study

Author: Florian, Sandra, Ichou, Mathieu, Panico, Lidia, Pinel-Jacquemin, Stéphanie, Vrijkotte, Tanja G. M., Harskamp-Van Ginkel, Margreet W., Huang, Rae-Chi, Carson, Jennie, Rodriguez, Loreto Santa Marina, Subiza-Pérez, Mikel, Vrijheid, Martine, Fernández-Barrés, Sílvia, Yang, Tiffany C., Wright, John, Corpeleijn, Eva, Cardol, Marloes, Isaevska, Elena, Moccia, Chiara, Kooijman, Marjolein N., Voerman, Ellis, Jaddoe, Vincent, Welten, Marieke, Spada, Elena, Rebagliato, Marisa, Beneito, Andrea, Ronfani, Luca, Charles, Marie-Aline, Florian, Sandra, Ichou, Mathieu, Panico, Lidia, Pinel-Jacquemin, Stéphanie, Vrijkotte, Tanja G. M., Harskamp-Van Ginkel, Margreet W., Huang, Rae-Chi, Carson, Jennie, Rodriguez, Loreto Santa Marina, Subiza-Pérez, Mikel, Vrijheid, Martine, Fernández-Barrés, Sílvia, Yang, Tiffany C., Wright, John, Corpeleijn, Eva, Cardol, Marloes, Isaevska, Elena, Moccia, Chiara, Kooijman, Marjolein N., Voerman, Ellis, Jaddoe, Vincent, Welten, Marieke, Spada, Elena, Rebagliato, Marisa, Beneito, Andrea, Ronfani, Luca, and Charles, Marie-Aline
Abstract: Objective: Research on adults has identified an immigrant health advantage, known as the 'immigrant health paradox', by which migrants exhibit better health outcomes than natives. Is this health advantage transferred from parents to children in the form of higher birth weight relative to children of natives? Setting: Western Europe and Australia. Participants: We use data from nine birth cohorts participating in the LifeCycle Project, including five studies with large samples of immigrants' children: Etude Longitudinale Française depuis l'Enfance - France (N=12 494), the Raine Study - Australia (N=2283), Born in Bradford - UK (N=4132), Amsterdam Born Children and their Development study - Netherlands (N=4030) and the Generation R study - Netherlands (N=4877). We include male and female babies born to immigrant and native parents. Primary and secondary outcome measures: The primary outcome is birth weight measured in grams. Different specifications were tested: birth weight as a continuous variable including all births (DV1), the same variable but excluding babies born with over 4500 g (DV2), low birth weight as a 0-1 binary variable (1=birth weight below 2500 g) (DV3). Results using these three measures were similar, only results using DV1 are presented. Parental migration status is measured in four categories: both parents natives, both born abroad, only mother born abroad and only father born abroad. Results: Two patterns in children's birth weight by parental migration status emerged: higher birth weight among children of immigrants in France (+12 g, p < 0.10) and Australia (+40 g, p < 0.10) and lower birth weight among children of immigrants in the UK (-82 g, p < 0.05) and the Netherlands (-80 g and -73 g, p < 0.001) compared with natives' children. Smoking during pregnancy emerged as a mechanism explaining some of the birth weight gaps between children of immigrants and natives. Conclusion: The immigrant health advantage is not universally transferred to childr
Published: 2023

11. Parental Discontent with Infant Sleep During the First Two Years of Life.

Author: Harskamp–van Ginkel, Margreet W., Imkamp, Nicola L.E., van Houtum, Lieke, Vrijkotte, Tanja G.M., Ben Haddi-Toutouh, Yassmina, and Chinapaw, Mai J. M.
Subjects: *INFANTS, *SLEEP, *DISCONTENT, *LOGISTIC regression analysis
Abstract: Problematic sleep in infants can have a high impact on families. We examined parental discontent with infant sleep in the first six months of life and parent-perceived problematic sleep during the second year of life. We used Sarphati Cohort data of 1471 children. During periodic youth health care visits in the first six months of life, professionals registered parental discontent with infant sleep. In the second year of life, parents filled out the Brief Infant Sleep Questionnaire (BISQ), from which we defined parent-perceived problematic sleep and BISQ-defined problematic sleep. We examined the association of parental discontent with infant sleep during the first six months with both BISQ-derived outcomes up to age two, using multivariable logistic regression analysis. 26% of parents were discontented with infant sleep during the first six months of life. During the second year of life, 27% of the parents perceived their child's sleep as problematic, and 9% of the infants had BISQ-defined problematic sleep. Early parental discontent with infant sleep was associated with parent-perceived problematic sleep [adjusted OR 2.50 (95% CI 1.91–3.28)], and BISQ-defined problematic sleep [adjusted OR 1.88 (1.11–3.17)]. Early registered parental discontent with infant sleep was a predictor of parent-perceived problematic sleep in early toddlerhood. Registering parental discontent during infancy might enable professionals to identify a group of infants at risk for later problematic sleep. We recommend screening and parental support for sleep difficulties in an early stage. [ABSTRACT FROM AUTHOR]
Published: 2023
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12. Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis

Author: Elhakeem, Ahmed, primary, Taylor, Amy E, additional, Inskip, Hazel M, additional, Huang, Jonathan Y, additional, Mansell, Toby, additional, Rodrigues, Carina, additional, Asta, Federica, additional, Blaauwendraad, Sophia M, additional, Håberg, Siri E, additional, Halliday, Jane, additional, Harskamp-van Ginkel, Margreet W, additional, He, Jian-Rong, additional, Jaddoe, Vincent W V, additional, Lewis, Sharon, additional, Maher, Gillian M, additional, Manios, Yannis, additional, McCarthy, Fergus P, additional, Reiss, Irwin K M, additional, Rusconi, Franca, additional, Salika, Theodosia, additional, Tafflet, Muriel, additional, Qiu, Xiu, additional, Åsvold, Bjørn O, additional, Burgner, David, additional, Chan, Jerry K Y, additional, Gagliardi, Luigi, additional, Gaillard, Romy, additional, Heude, Barbara, additional, Magnus, Maria C, additional, Moschonis, George, additional, Murray, Deirdre, additional, Nelson, Scott M, additional, Porta, Daniela, additional, Saffery, Richard, additional, Barros, Henrique, additional, Eriksson, Johan G, additional, Vrijkotte, Tanja G M, additional, and Lawlor, Deborah A, additional
Published: 2023
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13. The need of having a plan in excessive infant crying – A qualitative study of parents' experiences of healthcare support

Author: Harskamp‐Van Ginkel, Margreet W., primary, Klazema, Willemien, additional, Hoogsteder, Mariëtte H. H., additional, Chinapaw, Mai J. M., additional, and van Houtum, Lieke, additional
Published: 2022
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14. Exposure to natural environments during pregnancy and birth outcomes in 11 European birth cohorts

Author: Torres Toda, Maria, primary, Avraam, Demetris, additional, James Cadman, Timothy, additional, Fossati, Serena, additional, de Castro, Montserrat, additional, Dedele, Audrius, additional, Donovan, Geoffrey, additional, Elhakeem, Ahmed, additional, Estarlich, Marisa, additional, Fernandes, Amanda, additional, Gonçalves, Romy, additional, Grazuleviciene, Regina, additional, Harris, Jennifer R., additional, Harskamp-van Ginkel, Margreet W, additional, Heude, Barbara, additional, Ibarluzea, Jesús, additional, Iñiguez, Carmen, additional, WV Jaddoe, Vincent, additional, Lawlor, Deborah, additional, Lertxundi, Aitana, additional, Lepeule, Johanna, additional, McEachan, Rosemary, additional, Moirano, Giovenale, additional, LT Nader, Johanna, additional, Nybo Andersen, Anne-Marie, additional, Pedersen, Marie, additional, Pizzi, Costanza, additional, Roumeliotaki, Theano, additional, Santos, Susana, additional, Sunyer, Jordi, additional, Yang, Tiffany, additional, Vafeiadi, Marina, additional, GM Vrijkotte, Tanja, additional, Nieuwenhuijsen, Mark, additional, Vrijheid, Martine, additional, Foraster, Maria, additional, and Dadvand, Payam, additional
Published: 2022
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15. Mother’s education and offspring asthma risk in 10 European cohort studies

Author: Lewis, Kate Marie, Ruiz, Milagros, Goldblatt, Peter, Morrison, Joana, Porta, Daniela, Forastiere, Francesco, Hryhorczuk, Daniel, Zvinchuk, Oleksandr, Saurel-Cubizolles, Marie-Josephe, Lioret, Sandrine, Annesi-Maesano, Isabella, Vrijheid, Martine, Torrent, Maties, Iniguez, Carmen, Larranaga, Isabel, Harskamp-van Ginkel, Margreet W., Vrijkotte, Tanja G. M., Klanova, Jana, Svancara, Jan, Barross, Henrique, Correia, Sofia, Jarvelin, Marjo-Riitta, Taanila, Anja, Ludvigsson, Johnny, Faresjo, Tomas, Marmot, Michael, and Pikhart, Hynek
Published: 2017
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16. Digitale-mediagebruik en slaap bij jongeren

Author: de Poot, Simone, Harskamp-van Ginkel, Margreet W., Vrijkotte, Tanja G. M., Public and occupational health, APH - Health Behaviors & Chronic Diseases, APH - Methodology, Amsterdam Reproduction & Development (AR&D), and APH - Aging & Later Life
Abstract: OBJECTIVE: To test whether parental rules regarding the amount of digital media use is associated with the sleep of Dutch adolescents, and whether this is indirectly due to lower digital media use. DESIGN: Cross-sectional study METHOD: Adolescents and their parents of the Amsterdam Born Children and their Development (ABCD) study completed questionnaires in 2019 at the age of 15-16 years (n=1369; 56% girls). Parents and adolescents reported whether there are rules regarding the amount of digital media use. The adolescents also reported their daily amount of digital media use, sleep duration, bedtime and sleep quality according to the Pittsburgh Sleep Quality Index (PSQI). We tested the association between rules and sleep duration, bedtime and sleep quality in adolescents using multivariate regression analysis. Using mediation analysis we tested whether rules were also indirectly associated with sleep outcome measures through the amount of digital media use. RESULTS: Setting rules regarding digital media use was related to sleep duration; 6.8 minutes (95%CI:0.1;13.5) longer with inconsistently experienced rules and 18.5 minutes (95%CI:9.2;27.8) longer with consistently existing rules. Setting rules was also related to bedtime; 10 minutes (95%CI: -17;-4) earlier with inconsistently experienced rules and 29 minutes (95%CI:-38;-2) earlier with consistently existing rules. Setting rules was not directly associated with sleep quality. Indirectly, rules were associated with longer sleep duration, earlier bedtime and better sleep quality due to lower digital media use per day. CONCLUSION: Parental rules regarding the amount of digital media use is associated with better sleep of adolescents. This is partly explained by lower digital media use.
Published: 2022

17. Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood

Author: Elhakeem, Ahmed, Taylor, Amy E., Inskip, Hazel M., Huang, Jonathan, Tafflet, Muriel, Vinther, Johan L., Asta, Federica, Erkamp, Jan S., Gagliardi, Luigi, Guerlich, Kathrin, Halliday, Jane, Harskamp-van Ginkel, Margreet W., He, Jian-Rong, Jaddoe, Vincent W. V., Lewis, Sharon, Maher, Gillian M., Manios, Yannis, Mansell, Toby, McCarthy, Fergus P., McDonald, Sheila W., Medda, Emanuela, Nisticò, Lorenza, de Moira, Angela Pinot, Popovic, Maja, Reiss, Irwin K. M., Rodrigues, Carina, Salika, Theodosia, Smith, Ash, Stazi, Maria A., Walker, Caroline, Wu, Muci, Åsvold, Bjørn O., Barros, Henrique, Brescianini, Sonia, Burgner, David, Chan, Jerry K. Y., Charles, Marie-Aline, Eriksson, Johan G., Gaillard, Romy, Grote, Veit, Håberg, Siri E., Heude, Barbara, Koletzko, Berthold, Morton, Susan, Moschonis, George, Murray, Deirdre, O’Mahony, Desmond, Porta, Daniela, Qiu, Xiu, Richiardi, Lorenzo, Rusconi, Franca, Saffery, Richard, Tough, Suzanne C., Vrijkotte, Tanja G. M., Nelson, Scott M., Nybo Andersen, Anne-Marie, Magnus, Maria C., Lawlor, Deborah A., Clinicum, Research Programs Unit, Johan Eriksson / Principal Investigator, Department of General Practice and Primary Health Care, University of Helsinki, Public and occupational health, APH - Health Behaviors & Chronic Diseases, APH - Methodology, ARD - Amsterdam Reproduction and Development, APH - Aging & Later Life, and Pediatrics
Subjects: Adult, Male, Reproductive Techniques, Assisted, Adolescent, CHILDHOOD, EMBRYO-TRANSFER, FRESH, INFERTILITY, Cohort Studies, Reproductive Techniques, Pregnancy, Semen, Child, Child, Preschool, Embryo Transfer, Female, Humans, Infant, Obesity, Adiposity, Preschool, Embryo Transfer/methods, Uncategorized, OUTCOMES, BORN, Reproductive Techniques, Assisted/adverse effects, General Medicine, Obesity/epidemiology, Assisted, 3121 General medicine, internal medicine and other clinical medicine, HEALTH, IN-VITRO FERTILIZATION
Abstract: IMPORTANCE People conceived using assisted reproductive technology (ART) make up anincreasing proportion of the world’s population.OBJECTIVE To investigate the association of ART conception with offspring growth and adiposityfrom infancy to early adulthood in a large multicohort study.DESIGN, SETTING, AND PARTICIPANTS This cohort study used a prespecified coordinated analysisacross 26 European, Asia-Pacific, and North American population-based cohort studies that includedpeople born between 1984 and 2018, with mean ages at assessment of growth and adiposityoutcomes from 0.6 months to 27.4 years. Data were analyzed between November 2019 andFebruary 2022.EXPOSURES Conception by ART (mostly in vitro fertilization, intracytoplasmic sperm injection, andembryo transfer) vs natural conception (NC; without any medically assisted reproduction).MAIN OUTCOMES AND MEASURES The main outcomes were length / height, weight, and bodymass index (BMI; calculated as weight in kilograms divided by height in meters squared). Each cohortwas analyzed separately with adjustment for maternal BMI, age, smoking, education, parity, andethnicity and offspring sex and age. Results were combined in random effects meta-analysis for 13age groups.RESULTS Up to 158 066 offspring (4329 conceived by ART) were included in each age-group metaanalysis, with between 47.6% to 60.6% females in each cohort. Compared with offspring who wereNC, offspring conceived via ART were shorter, lighter, and thinner from infancy to early adolescence,with differences largest at the youngest ages and attenuating with older child age. For example,adjusted mean differences in offspring weight were −0.27 (95% CI, −0.39 to −0.16) SD units at ageyounger than 3 months, −0.16 (95% CI, −0.22 to −0.09) SD units at age 17 to 23 months, −0.07 (95%CI, −0.10 to −0.04) SD units at age 6 to 9 years, and −0.02 (95% CI, −0.15 to 0.12) SD units at age 14to 17 years. Smaller offspring size was limited to individuals conceived by fresh but not frozen embryotransfer compared with those who were NC (eg, difference in weight at age 4 to 5 years was −0.14[95% CI, −0.20 to −0.07] SD units for fresh embryo transfer vs NC and 0.00 [95% CI, −0.15 to 0.15SD units for frozen embryo transfer vs NC). More marked differences were seen for body fatmeasurements, and there was imprecise evidence that offspring conceived by ART developedgreater adiposity by early adulthood (eg, ART vs NC difference in fat mass index at age older than 17years: 0.23 [95% CI, −0.04 to 0.50] SD units).CONCLUSIONS AND RELEVANCE These findings suggest that people conceiving or conceived byART can be reassured that differences in early growth and adiposity are small and no longer evidentby late adolescence
Published: 2022

18. Exposure to natural environments during pregnancy and birth outcomes in 11 European birth cohorts

Author: Medicina preventiva y salud pública, Prebentzio medikuntza eta osasun publikoa, Torres Toda, María, Avraam, Demetris, Cadman, Timothy James, Fossati, Serena, De Castro, Montserrat, Dedele, Audrius, Donovan, Geoffrey, Elhakeem, Ahmed, Estarlich, Marisa, Fernandes, Amanda, Gonçalves, Romy, Grazuleviciene, Regina, Harris, Jennifer R., Harskamp-van Ginkel, Margreet W., Heude, Barbara, Ibarluzea Maurolagoitia, Jesús María, Iñiguez, Carmen, Jaddoe, Vincent W. V., Lawlor, Deborah, Lertxundi Manterola, Aitana, Lepeule, Johanna, McEachan, Rosemary, Moirano, Giovenale, Nader, Johanna L. T., Andersen, Anne-Marie Nybo, Pedersen, Marie, Pizzi, Costanza, Roumeliotaki, Theano, Santos, Susana, Sunyer, Jordi, Yang, Tiffany, Vafeiadi, Marina, Vrijkotte, Tanja G. M., Nieuwenhuijsen, Mark, Vrijheid, Martine, Foraster, Maria, Dadvand, Payam, Medicina preventiva y salud pública, Prebentzio medikuntza eta osasun publikoa, Torres Toda, María, Avraam, Demetris, Cadman, Timothy James, Fossati, Serena, De Castro, Montserrat, Dedele, Audrius, Donovan, Geoffrey, Elhakeem, Ahmed, Estarlich, Marisa, Fernandes, Amanda, Gonçalves, Romy, Grazuleviciene, Regina, Harris, Jennifer R., Harskamp-van Ginkel, Margreet W., Heude, Barbara, Ibarluzea Maurolagoitia, Jesús María, Iñiguez, Carmen, Jaddoe, Vincent W. V., Lawlor, Deborah, Lertxundi Manterola, Aitana, Lepeule, Johanna, McEachan, Rosemary, Moirano, Giovenale, Nader, Johanna L. T., Andersen, Anne-Marie Nybo, Pedersen, Marie, Pizzi, Costanza, Roumeliotaki, Theano, Santos, Susana, Sunyer, Jordi, Yang, Tiffany, Vafeiadi, Marina, Vrijkotte, Tanja G. M., Nieuwenhuijsen, Mark, Vrijheid, Martine, Foraster, Maria, and Dadvand, Payam
Abstract: Research suggests that maternal exposure to natural environments (i.e., green and blue spaces) promotes healthy fetal growth. However, the available evidence is heterogeneous across regions, with very few studies on the effects of blue spaces. This study evaluated associations between maternal exposure to natural environments and birth outcomes in 11 birth cohorts across nine European countries. This study, part of the LifeCycle project, was based on a total sample size of 69,683 newborns with harmonised data. For each participant, we calculated seven indicators of residential exposure to natural environments: surrounding greenspace in 100m, 300m, and 500m using Normalised Difference Vegetation Index (NDVI) buffers, distance to the nearest green space, accessibility to green space, distance to the nearest blue space, and accessibility to blue space. Measures of birth weight and small for gestational age (SGA) were extracted from hospital records. We used pooled linear and logistic regression models to estimate associations between exposure to the natural environment and birth outcomes, controlling for the relevant covariates. We evaluated the potential effect modification by socioeconomic status (SES) and region of Europe and the influence of ambient air pollution on the associations. In the pooled analyses, residential surrounding greenspace in 100m, 300m, and 500m buffer was associated with increased birth weight and lower odds for SGA. Higher residential distance to green space was associated with lower birth weight and higher odds for SGA. We observed close to null associations for accessibility to green space and exposure to blue space. We found stronger estimated magnitudes for those participants with lower educational levels, from more deprived areas, and living in the northern European region. Our associations did not change notably after adjustment for air pollution. These findings may support implementing policies to promote natural environments in our cit
Published: 2022

19. Exposure to natural environments during pregnancy and birth outcomes in 11 european birth cohorts

Author: Torres Toda, Maria, Avraam, Demetris, James Cadman, Timothy, Fossati, Serena, de Castro, Montserrat, Dedele, Audrius, Donovan, Geoffrey, Elhakeem, Ahmed, Estarlich, Marisa, Fernandes, Amanda, Gonçalves, Romy, Grazuleviciene, Regina, Harris, Jennifer R., Harskamp-van Ginkel, Margreet W., Heude, Barbara, Ibarluzea, Jesús, Iñiguez, Carmen, WV Jaddoe, Vincent, Lawlor, Deborah, Lertxundi, Aitana, Lepeule, Johanna, McEachan, Rosemary, Moirano, Giovenale, LT Nader, Johanna, Nybo Andersen, Anne Marie, Pedersen, Marie, Pizzi, Costanza, Roumeliotaki, Theano, Santos, Susana, Sunyer, Jordi, Yang, Tiffany, Vafeiadi, Marina, GM Vrijkotte, Tanja, Nieuwenhuijsen, Mark, Vrijheid, Martine, Foraster, Maria, Dadvand, Payam, Torres Toda, Maria, Avraam, Demetris, James Cadman, Timothy, Fossati, Serena, de Castro, Montserrat, Dedele, Audrius, Donovan, Geoffrey, Elhakeem, Ahmed, Estarlich, Marisa, Fernandes, Amanda, Gonçalves, Romy, Grazuleviciene, Regina, Harris, Jennifer R., Harskamp-van Ginkel, Margreet W., Heude, Barbara, Ibarluzea, Jesús, Iñiguez, Carmen, WV Jaddoe, Vincent, Lawlor, Deborah, Lertxundi, Aitana, Lepeule, Johanna, McEachan, Rosemary, Moirano, Giovenale, LT Nader, Johanna, Nybo Andersen, Anne Marie, Pedersen, Marie, Pizzi, Costanza, Roumeliotaki, Theano, Santos, Susana, Sunyer, Jordi, Yang, Tiffany, Vafeiadi, Marina, GM Vrijkotte, Tanja, Nieuwenhuijsen, Mark, Vrijheid, Martine, Foraster, Maria, and Dadvand, Payam
Abstract: Research suggests that maternal exposure to natural environments (i.e., green and blue spaces) promotes healthy fetal growth. However, the available evidence is heterogeneous across regions, with very few studies on the effects of blue spaces. This study evaluated associations between maternal exposure to natural environments and birth outcomes in 11 birth cohorts across nine European countries. This study, part of the LifeCycle project, was based on a total sample size of 69,683 newborns with harmonised data. For each participant, we calculated seven indicators of residential exposure to natural environments: surrounding greenspace in 100m, 300m, and 500m using Normalised Difference Vegetation Index (NDVI) buffers, distance to the nearest green space, accessibility to green space, distance to the nearest blue space, and accessibility to blue space. Measures of birth weight and small for gestational age (SGA) were extracted from hospital records. We used pooled linear and logistic regression models to estimate associations between exposure to the natural environment and birth outcomes, controlling for the relevant covariates. We evaluated the potential effect modification by socioeconomic status (SES) and region of Europe and the influence of ambient air pollution on the associations. In the pooled analyses, residential surrounding greenspace in 100m, 300m, and 500m buffer was associated with increased birth weight and lower odds for SGA. Higher residential distance to green space was associated with lower birth weight and higher odds for SGA. We observed close to null associations for accessibility to green space and exposure to blue space. We found stronger estimated magnitudes for those participants with lower educational levels, from more deprived areas, and living in the northern European region. Our associations did not change notably after adjustment for air pollution. These findings may support implementing policies to promote natural environments in our cit, Research suggests that maternal exposure to natural environments (i.e., green and blue spaces) promotes healthy fetal growth. However, the available evidence is heterogeneous across regions, with very few studies on the effects of blue spaces. This study evaluated associations between maternal exposure to natural environments and birth outcomes in 11 birth cohorts across nine European countries. This study, part of the LifeCycle project, was based on a total sample size of 69,683 newborns with harmonised data. For each participant, we calculated seven indicators of residential exposure to natural environments: surrounding greenspace in 100m, 300m, and 500m using Normalised Difference Vegetation Index (NDVI) buffers, distance to the nearest green space, accessibility to green space, distance to the nearest blue space, and accessibility to blue space. Measures of birth weight and small for gestational age (SGA) were extracted from hospital records. We used pooled linear and logistic regression models to estimate associations between exposure to the natural environment and birth outcomes, controlling for the relevant covariates. We evaluated the potential effect modification by socioeconomic status (SES) and region of Europe and the influence of ambient air pollution on the associations. In the pooled analyses, residential surrounding greenspace in 100m, 300m, and 500m buffer was associated with increased birth weight and lower odds for SGA. Higher residential distance to green space was associated with lower birth weight and higher odds for SGA. We observed close to null associations for accessibility to green space and exposure to blue space. We found stronger estimated magnitudes for those participants with lower educational levels, from more deprived areas, and living in the northern European region. Our associations did not change notably after adjustment for air pollution. These findings may support implementing policies to promote natural environments in our
Published: 2022

20. The need of having a plan in excessive infant crying – A qualitative study of parents' experiences of healthcare support.

Author: Harskamp‐Van Ginkel, Margreet W., Klazema, Willemien, Hoogsteder, Mariëtte H. H., Chinapaw, Mai J. M., and van Houtum, Lieke
Subjects: *INFANTS, *PARENT attitudes, *PARENTS, *CRYING, *MATERNITY nursing, *PARENT-infant relationships, *MEDICALIZATION
Abstract: Aim: Excessive infant crying increases parents' concerns regarding their infant's health and the burden of parenting. We aimed to gain insight into the healthcare support needs of parents with excessively crying infants. Methods: An exploratory qualitative study was conducted in the Netherlands. We performed semi‐structured interviews with parents of 12 infants between June and December 2020, followed by inductive and deductive thematic analysis. Results: Parents described what their needs were with regard to the assessment of infant crying and support by professionals. Long‐lasting crying made parents feel that there must be a somatic cause. If they could soothe their infant, they gained more confidence that their infant was healthy. We identified four interrelated themes: (i) confidence in the professional; (ii) seeking a somatic cause for the crying; (iii) seeking acknowledgment; and (iv) exhaustion of parents and feelings of failure. Conclusion: Parental support needs were best fulfilled by professionals who took them seriously, demonstrated medical expertise, and offered a practical plan. Perinatal parental education on normal infant behaviour and infant soothing techniques might improve parental self‐efficacy at an early stage and prevent medicalization of excessive crying. [ABSTRACT FROM AUTHOR]
Published: 2023
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21. Association of assisted reproductive technology with long-term offspring cardiometabolic health: a multi-cohort study

Author: Elhakeem, Ahmed, primary, Taylor, Amy E, additional, Inskip, Hazel M, additional, Huang, Jonathan, additional, Mansell, Toby, additional, Rodrigues, Carina, additional, Asta, Federica, additional, Blaauwendraad, Sophie M, additional, Haberg, Siri E, additional, Halliday, Jane, additional, Harskamp-van Ginkel, Margreet W, additional, He, Jian-Rong, additional, Jaddoe, Vincent WV, additional, Lewis, Sharon, additional, Maher, Gillian M, additional, Manios, Yannis, additional, McCarthy, Fergus P, additional, Reiss, Irwin KM, additional, Rusconi, Franca, additional, Salika, Theodosia, additional, Tafflet, Muriel, additional, Qiu, Xiu, additional, Asvold, Bjorn O, additional, Burgner, David, additional, Chan, Jerry KY, additional, Gagliardi, Luigi, additional, Gaillard, Romy, additional, Heude, Barbara, additional, Magnus, Maria C, additional, Moschonis, George, additional, Murray, Deirdre, additional, Nelson, Scott M, additional, Porta, Daniela, additional, Saffery, Richard, additional, Barros, Henrique, additional, Eriksson, Johan G, additional, Vrijkotte, Tanja GM, additional, and Lawlor, Deborah A, additional
Published: 2022
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22. Potential determinants during 'the first 1000 days of life' of sleep problems in school-aged children

Author: Leerstoel Lippe, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Harskamp-van Ginkel, Margreet W, Kool, Ruth E, van Houtum, Lieke, Belmon, Laura S, Huss, Anke, Chinapaw, Mai J M, Vrijkotte, Tanja G M, Leerstoel Lippe, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Harskamp-van Ginkel, Margreet W, Kool, Ruth E, van Houtum, Lieke, Belmon, Laura S, Huss, Anke, Chinapaw, Mai J M, and Vrijkotte, Tanja G M
Published: 2020

23. Effects of Assisted Reproductive Technology on Offspring Growth and Adiposity from Infancy to Early Adulthood: Coordinated Analysis of 26 Multinational Cohort Studies

Author: Elhakeem, Ahmed, primary, Taylor, Amy E., additional, Inskip, Hazel M., additional, Huang, Jonathan, additional, Tafflet, Muriel, additional, Vinther, Johan L., additional, Asta, Federica, additional, Erkamp, Jan S., additional, Gagliardi, Luigi, additional, Guerlich, Kathrin, additional, Halliday, Jane, additional, Harskamp-van Ginkel, Margreet W., additional, He, Jian-Rong, additional, Jaddoe, Vincent W.V., additional, Lewis, Sharon, additional, Maher, Gillian M., additional, Manios, Yannis, additional, Mansell, Toby, additional, McCarthy, Fergus, additional, McDonald, Sheila W., additional, Medda, Emanula, additional, Nisticò, Lorenza, additional, Pinot de Moira, Angela, additional, Popovic, Maja, additional, Reiss, Irwin K.M., additional, Rodrigues, Carina, additional, Salika, Theodosia, additional, Smith, Ash, additional, Stazi, Maria A., additional, Walker, Caroline, additional, Wu, Muci, additional, Åsvold, Bjørn Olav, additional, Barros, Henrique, additional, Brescianini, Sonia, additional, Burgner, David, additional, Chan, Jerry K.Y., additional, Charles, Marie-Aline, additional, Eriksson, Johan G., additional, Gaillard, Romy, additional, Grote, Veit, additional, Håberg, Siri E., additional, Heude, Barbara, additional, Koletzko, Berthold, additional, Morton, Susan, additional, Moschonis, George, additional, Murray, Deirdre, additional, O'Mahony, Desmond, additional, Porta, Daniela, additional, Qiu, Xiu, additional, Richiardi, Lorenzo, additional, Rusconi, Franca, additional, Saffery, Richard, additional, Tough, Suzanne C., additional, Vrijkotte, Tanja G.M., additional, Nelson, Scott M., additional, Andersen, Anne-Marie Nybo, additional, Magnus, Maria C., additional, and Lawlor, Deborah A., additional
Published: 2021
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24. Correction: The cross-sectional association of parental psychosocial status with children's Body Mass Index z-score and the mediating role of children's energy balance behaviors—the ABCD Study.

Author: Overman, Meredith L., Vrijkotte, Tanja, Sánchez Castro, Yolanda M., Harskamp-van Ginkel, Margreet W., Hunsberger, Monica, Renders, Carry M., Kremers, Stef P. J., and Chinapaw, Mai J. M.
Subjects: BODY mass index
Abstract: This document is a correction notice for an article titled "The cross-sectional association of parental psychosocial status with children's Body Mass Index z-score and the mediating role of children's energy balance behaviors—the ABCD Study." The correction addresses errors in the author contributions section. The correct contributions are listed, including the roles of each author in the conceptualization, data curation, formal analysis, funding acquisition, investigation, methodology, supervision, and writing of the article. The correction is provided by the authors Meredith L. Overman, Tanja Vrijkotte, Yolanda M. Sánchez Castro, Margreet W. Harskamp-van Ginkel, Monica Hunsberger, Carry M. Renders, Stef P.J. Kremers, and Mai J.M. Chinapaw. [Extracted from the article]
Published: 2024
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25. Gestational sleep deprivation is associated with higher offspring body mass index and blood pressure

Author: Harskamp-van Ginkel, Margreet W, primary, Ierodiakonou, Despo, additional, Margetaki, Katerina, additional, Vafeiadi, Marina, additional, Karachaliou, Marianna, additional, Kogevinas, Manolis, additional, Vrijkotte, Tanja G M, additional, and Chatzi, Leda, additional
Published: 2020
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26. Sleep during Infancy and Associations with Childhood Body Composition: A Systematic Review and Narrative Synthesis

Author: Harskamp-van Ginkel, Margreet W., primary, Chinapaw, Mai J.M., additional, Harmsen, Irene A., additional, Anujuo, Kenneth O., additional, Daams, Joost G., additional, and Vrijkotte, Tanja G.M., additional
Published: 2020
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27. Does early onset asthma increase childhood obesity risk? : A pooled analysis of 16 European cohorts

Author: Contreras, Zuelma A, Chen, Zhanghua, Roumeliotaki, Theano, Annesi-Maesano, Isabella, Baïz, Nour, von Berg, Andrea, Bergström, Anna, Crozier, Sarah, Duijts, Liesbeth, Ekström, Sandra, Eller, Esben, Fantini, Maria P, Kjaer, Henrik Fomsgaard, Forastiere, Francesco, Gerhard, Beatrix, Gori, Davide, Harskamp-van Ginkel, Margreet W, Heinrich, Joachim, Iñiguez, Carmen, Inskip, Hazel, Keil, Thomas, Kogevinas, Manolis, Lau, Susanne, Lehmann, Irina, Maier, Dieter, van Meel, Evelien R, Mommers, Monique, Murcia, Mario, Porta, Daniela, Smit, Henriëtte A, Standl, Marie, Stratakis, Nikos, Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Vrijkotte, Tanja G M, Wijga, Alet H, Berhane, Kiros, Gilliland, Frank, Chatzi, Leda, Contreras, Zuelma A, Chen, Zhanghua, Roumeliotaki, Theano, Annesi-Maesano, Isabella, Baïz, Nour, von Berg, Andrea, Bergström, Anna, Crozier, Sarah, Duijts, Liesbeth, Ekström, Sandra, Eller, Esben, Fantini, Maria P, Kjaer, Henrik Fomsgaard, Forastiere, Francesco, Gerhard, Beatrix, Gori, Davide, Harskamp-van Ginkel, Margreet W, Heinrich, Joachim, Iñiguez, Carmen, Inskip, Hazel, Keil, Thomas, Kogevinas, Manolis, Lau, Susanne, Lehmann, Irina, Maier, Dieter, van Meel, Evelien R, Mommers, Monique, Murcia, Mario, Porta, Daniela, Smit, Henriëtte A, Standl, Marie, Stratakis, Nikos, Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Vrijkotte, Tanja G M, Wijga, Alet H, Berhane, Kiros, Gilliland, Frank, and Chatzi, Leda
Published: 2018

28. Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts

Author: Contreras, Zuelma A., Contreras, Zuelma A., Chen, Zhanghua, Roumeliotaki, Theano, Annesi-Maesano, Isabella, Baiz, Nour, von Berg, Andrea, Bergstrom, Anna, Crozier, Sarah, Duijts, Liesbeth, Ekstrom, Sandra, Eller, Esben, Fantini, Maria P., Kjaer, Henrik Fomsgaard, Forastiere, Francesco, Gerhard, Beatrix, Gori, Davide, Harskamp-van Ginkel, Margreet W., Heinrich, Joachim, Iniguez, Carmen, Inskip, Hazel, Keil, Thomas, Kogevinas, Manolis, Lau, Susanne, Lehmann, Irina, Maier, Dieter, van Meel, Evelien R., Mommers, Monique, Murcia, Mario, Porta, Daniela, Smit, Henriette A., Standl, Marie, Stratakis, Nikos, Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Vrijkotte, Tanja G. M., Wijga, Alet H., Berhane, Kiros, Gilliland, Frank, Chatzi, Leda, Contreras, Zuelma A., Contreras, Zuelma A., Chen, Zhanghua, Roumeliotaki, Theano, Annesi-Maesano, Isabella, Baiz, Nour, von Berg, Andrea, Bergstrom, Anna, Crozier, Sarah, Duijts, Liesbeth, Ekstrom, Sandra, Eller, Esben, Fantini, Maria P., Kjaer, Henrik Fomsgaard, Forastiere, Francesco, Gerhard, Beatrix, Gori, Davide, Harskamp-van Ginkel, Margreet W., Heinrich, Joachim, Iniguez, Carmen, Inskip, Hazel, Keil, Thomas, Kogevinas, Manolis, Lau, Susanne, Lehmann, Irina, Maier, Dieter, van Meel, Evelien R., Mommers, Monique, Murcia, Mario, Porta, Daniela, Smit, Henriette A., Standl, Marie, Stratakis, Nikos, Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Vrijkotte, Tanja G. M., Wijga, Alet H., Berhane, Kiros, Gilliland, Frank, and Chatzi, Leda
Abstract: The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood.This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, The Netherlands, Spain, Sweden and the UK. We followed non-obese children at 3-4 years of age for incident obesity up to 8 years of age. Physician-diagnosed asthma, wheezing and allergic rhinitis were assessed up to 3-4 years of age.Children with physician-diagnosed asthma had a higher risk for incident obesity than those without asthma (adjusted hazard ratio (aHR) 1.66, 95% CI 1.18-2.33). Children with active asthma (wheeze in the last 12 months and physician-diagnosed asthma) exhibited a higher risk for obesity (aHR 1.98, 95% CI 1.31-3.00) than those without wheeze and asthma. Persistent wheezing was associated with increased risk for incident obesity compared to never wheezers (aHR 1.51, 95% CI 1.08-2.09).Early-onset asthma and wheezing may contribute to an increased risk of developing obesity in later childhood.
Published: 2018

29. Does early onset asthma increase childhood obesity risk?: A pooled analysis of 16 European cohorts

Author: Public Health Epidemiologie, Circulatory Health, Child Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Infectieziekten, Contreras, Zuelma A, Chen, Zhanghua, Roumeliotaki, Theano, Annesi-Maesano, Isabella, Baïz, Nour, von Berg, Andrea, Bergström, Anna, Crozier, Sarah, Duijts, Liesbeth, Ekström, Sandra, Eller, Esben, Fantini, Maria P, Kjaer, Henrik Fomsgaard, Forastiere, Francesco, Gerhard, Beatrix, Gori, Davide, Harskamp-van Ginkel, Margreet W, Heinrich, Joachim, Iñiguez, Carmen, Inskip, Hazel, Keil, Thomas, Kogevinas, Manolis, Lau, Susanne, Lehmann, Irina, Maier, Dieter, van Meel, Evelien R, Mommers, Monique, Murcia, Mario, Porta, Daniela, Smit, Henriëtte A, Standl, Marie, Stratakis, Nikos, Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Vrijkotte, Tanja G M, Wijga, Alet H, Berhane, Kiros, Gilliland, Frank, Chatzi, Leda, Public Health Epidemiologie, Circulatory Health, Child Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Infectieziekten, Contreras, Zuelma A, Chen, Zhanghua, Roumeliotaki, Theano, Annesi-Maesano, Isabella, Baïz, Nour, von Berg, Andrea, Bergström, Anna, Crozier, Sarah, Duijts, Liesbeth, Ekström, Sandra, Eller, Esben, Fantini, Maria P, Kjaer, Henrik Fomsgaard, Forastiere, Francesco, Gerhard, Beatrix, Gori, Davide, Harskamp-van Ginkel, Margreet W, Heinrich, Joachim, Iñiguez, Carmen, Inskip, Hazel, Keil, Thomas, Kogevinas, Manolis, Lau, Susanne, Lehmann, Irina, Maier, Dieter, van Meel, Evelien R, Mommers, Monique, Murcia, Mario, Porta, Daniela, Smit, Henriëtte A, Standl, Marie, Stratakis, Nikos, Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Vrijkotte, Tanja G M, Wijga, Alet H, Berhane, Kiros, Gilliland, Frank, and Chatzi, Leda
Published: 2018

30. Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts

Author: Contreras, Zuelma A., primary, Chen, Zhanghua, additional, Roumeliotaki, Theano, additional, Annesi-Maesano, Isabella, additional, Baïz, Nour, additional, von Berg, Andrea, additional, Bergström, Anna, additional, Crozier, Sarah, additional, Duijts, Liesbeth, additional, Ekström, Sandra, additional, Eller, Esben, additional, Fantini, Maria P., additional, Kjaer, Henrik Fomsgaard, additional, Forastiere, Francesco, additional, Gerhard, Beatrix, additional, Gori, Davide, additional, Harskamp-van Ginkel, Margreet W., additional, Heinrich, Joachim, additional, Iñiguez, Carmen, additional, Inskip, Hazel, additional, Keil, Thomas, additional, Kogevinas, Manolis, additional, Lau, Susanne, additional, Lehmann, Irina, additional, Maier, Dieter, additional, van Meel, Evelien R., additional, Mommers, Monique, additional, Murcia, Mario, additional, Porta, Daniela, additional, Smit, Henriëtte A., additional, Standl, Marie, additional, Stratakis, Nikos, additional, Sunyer, Jordi, additional, Thijs, Carel, additional, Torrent, Maties, additional, Vrijkotte, Tanja G.M., additional, Wijga, Alet H., additional, Berhane, Kiros, additional, Gilliland, Frank, additional, and Chatzi, Leda, additional
Published: 2018
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31. Drug dosing and pharmacokinetics in children with obesity a systematic review

Author: Harskamp-Van Ginkel, Margreet W., Hill, Kevin D., Becker, Kristian, Testoni, Daniela, Cohen-Wolkowiez, Michael, Gonzalez, Daniel, Barrett, Jeffrey S., Benjamin, Daniel K., Siegel, David A., Banks, Patricia, Watt, Kevin M., Berezny, Katherine Y., Capparelli, Edmund, Kearns, Gregory L., Laughon, Matthew, Muelenaer, Andre, O'Shea, T. Michael, Paul, Ian M., Van Den Anker, John, Wade, Kelly, and Walsh, Thomas J.
Subjects: Drug, medicine.medical_specialty, Metabolic Clearance Rate, media_common.quotation_subject, Childhood obesity, Article, Toxicology, Pharmacokinetics, Internal medicine, Medicine, Humans, Drug Dosage Calculations, Dosing, Obesity, Child, media_common, Body surface area, Volume of distribution, business.industry, Body Weight, medicine.disease, Systematic review, Child, Preschool, Pediatrics, Perinatology and Child Health, Body Composition, business
Abstract: Importance Obesity affects nearly one-sixth of US children and results in alterations to body composition and physiology that can affect drug disposition, possibly leading to therapeutic failure or toxic side effects. The depth of available literature regarding obesity’s effect on drug safety, pharmacokinetics, and dosing in obese children is unknown. Objective To perform a systematic literature review describing the current evidence of the effect of obesity on drug disposition in children. Evidence Review We searched the MEDLINE, Cochrane, and EMBASE databases (January 1, 1970-December 31, 2012) and included studies if they contained data on drug clearance, volume of distribution, or drug concentration in obese children (aged ≤18 years). We compared exposure and weight-normalized volume of distribution and clearance between obese and nonobese children. We explored the association between drug physicochemical properties and clearance and volume of distribution. Findings Twenty studies met the inclusion criteria and contained pharmacokinetic data for 21 drugs. The median number of obese children studied per drug was 10 (range, 1-112) and ages ranged from newborn to 29 years (1 study described pharmacokinetics in children and adults together). Dosing schema varied and were either a fixed dose (6 [29%]) or based on body weight (10 [48%]) and body surface area (4 [19%]). Clinically significant pharmacokinetic alterations were observed in obese children for 65% (11 of 17) of the studied drugs. Pharmacokinetic alterations resulted in substantial differences in exposure between obese and nonobese children for 38% (5 of 13) of the drugs. We found no association between drug lipophilicity or Biopharmaceutical Drug Disposition Classification System class and changes in volume of distribution or clearance due to obesity. Conclusions and Relevance Consensus is lacking on the most appropriate weight-based dosing strategy for obese children. Prospective pharmacokinetic trials in obese children are needed to ensure therapeutic efficacy and enhance drug safety.
Published: 2015

32. Sleep during Infancy and Associations with Childhood Body Composition: A Systematic Review and Narrative Synthesis

Author: Harskamp-van Ginkel, Margreet W., Chinapaw, Mai J.M., Harmsen, Irene A., Anujuo, Kenneth O., Daams, Joost G., and Vrijkotte, Tanja G.M.
Abstract: AbstractIntroduction:Prevention of childhood overweight should start as early as possible preferably in “the first 1000 days of life.” Sleep is one of the modifiable health behaviors during this age period, besides dietary intake and physical activity. The aim of this systematic review is to summarize the existing literature regarding the association between sleep during infancy (age ≤24 months) and body composition measures during childhood (age ≤12 years).Methods:We registered the protocol of this systematic review (PROSPERO registration no. CRD42018087088) and conducted the review following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. We searched for articles published until July 31, 2019 reporting on longitudinal associations with a minimal follow-up of 6 months. Methodological Quality was assessed and a narrative synthesis was performed.Results:We included 19 studies. Sleep was reported as sleep duration (n= 18) or sleep problems (n= 2). Sleep was assessed at least once before the age of 12 months in 14 out of the 19 studies. Methodological quality was rated as strong for five studies, moderate for five studies, and weak for nine studies.Conclusion:This narrative synthesis found inconsistent evidence that longer infant sleep duration during the first 2 years of life is associated with a healthier body composition during childhood.
Published: 2024
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33. A Study on Mediation by Offspring BMI in the Association between Maternal Obesity and Child Respiratory Outcomes in the Amsterdam Born and Their Development Study Cohort

Author: Harskamp-van Ginkel, Margreet W., primary, London, Stephanie J., additional, Magnus, Maria C., additional, Gademan, Maaike G., additional, and Vrijkotte, Tanja G., additional
Published: 2015
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34. Drug Dosing and Pharmacokinetics in Children With Obesity

Author: Harskamp-van Ginkel, Margreet W., primary, Hill, Kevin D., additional, Becker, Kristian C., additional, Testoni, Daniela, additional, Cohen-Wolkowiez, Michael, additional, Gonzalez, Daniel, additional, Barrett, Jeffrey S., additional, Benjamin, Daniel K., additional, Siegel, David A., additional, Banks, Patricia, additional, and Watt, Kevin M., additional
Published: 2015
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35. Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts

Author: Zuelma A Contreras, Evelien R. van Meel, Monique Mommers, Hazel Inskip, Leda Chatzi, Andrea von Berg, Sandra Ekström, Zhanghua Chen, Mario Murcia, Margreet W Harskamp-van Ginkel, Carmen Iñiguez, Beatrix Gerhard, Alet H. Wijga, Irina Lehmann, Esben Eller, Isabella Annesi-Maesano, Nour Baïz, Thomas Keil, Nikos Stratakis, Jordi Sunyer, Sarah Crozier, Joachim Heinrich, Marie Standl, Tanja G. M. Vrijkotte, Theano Roumeliotaki, Maties Torrent, Dieter Maier, Davide Gori, Daniela Porta, Maria Pia Fantini, Henrik Fomsgaard Kjaer, Henriette A. Smit, Manolis Kogevinas, Frank D. Gilliland, Francesco Forastiere, Susanne Lau, Anna Bergström, Liesbeth Duijts, Carel Thijs, Kiros Berhane, Public and occupational health, ARD - Amsterdam Reproduction and Development, APH - Aging & Later Life, APH - Health Behaviors & Chronic Diseases, APH - Methodology, Epidemiology, Pediatrics, Erasmus MC other, Contreras, Zuelma A., Chen, Zhanghua, Roumeliotaki, Theano, Annesi-Maesano, Isabella, Baïz, Nour, von Berg, Andrea, Bergström, Anna, Crozier, Sarah, Duijts, Liesbeth, Ekström, Sandra, Eller, Esben, Fantini, Maria P., Kjaer, Henrik Fomsgaard, Forastiere, Francesco, Gerhard, Beatrix, Gori, Davide, Harskamp-van Ginkel, Margreet W., Heinrich, Joachim, Iñiguez, Carmen, Inskip, Hazel, Keil, Thoma, Kogevinas, Manoli, Lau, Susanne, Lehmann, Irina, Maier, Dieter, van Meel, Evelien R., Mommers, Monique, Murcia, Mario, Porta, Daniela, Smit, Henriëtte A, Standl, Marie, Stratakis, Niko, Sunyer, Jordi, Thijs, Carel, Torrent, Matie, Vrijkotte, Tanja G M, Wijga, Alet H., Berhane, Kiro, Gilliland, Frank, Chatzi, Leda, Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care, Complexe Genetica, and RS: NUTRIM - R3 - Respiratory & Age-related Health
Subjects: Pulmonary and Respiratory Medicine, Male, Allergy, Pediatrics, medicine.medical_specialty, Pediatric Obesity, Infants -- Malalties, CHILDREN, Overweight, PROFILE, Childhood obesity, Article, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Risk Factors, Wheeze, medicine, Humans, 030212 general & internal medicine, Risk factor, Age of Onset, Child, Asma, Asthma, Respiratory Sounds, OVERWEIGHT, business.industry, INCIDENT ASTHMA, medicine.disease, Obesity, Rhinitis, Allergic, 3. Good health, respiratory tract diseases, BODY-MASS INDEX, ALLERGY, Europe, Phenotype, 030228 respiratory system, Child, Preschool, Obesitat, Female, Age of onset, medicine.symptom, business
Abstract: The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood.This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, The Netherlands, Spain, Sweden and the UK. We followed non-obese children at 3-4 years of age for incident obesity up to 8 years of age. Physician-diagnosed asthma, wheezing and allergic rhinitis were assessed up to 3-4 years of age.Children with physician-diagnosed asthma had a higher risk for incident obesity than those without asthma (adjusted hazard ratio (aHR) 1.66, 95% CI 1.18-2.33). Children with active asthma (wheeze in the last 12 months and physician-diagnosed asthma) exhibited a higher risk for obesity (aHR 1.98, 95% CI 1.31-3.00) than those without wheeze and asthma. Persistent wheezing was associated with increased risk for incident obesity compared to never wheezers (aHR 1.51, 95% CI 1.08-2.09).Early-onset asthma and wheezing may contribute to an increased risk of developing obesity in later childhood. This work was partially supported by the Southern California Environmental Health Sciences Center (grant # P30ES007048) funded by the National Institute of Environmental Health Sciences [PI Gilliland]. Dr. Contreras was supported by a grant from the NIH T32ES013678. MEDALL and CHICOS Projects: The research leading to these results has received funding from the European Community’s Seventh Framework Program(Health–F2-grantagreements No. 261357 and 241604). Per cohort ABCD: Data of the Amsterdam Born Children and their Development cohort study used in this research was in part supported by funds from the Netherlands Organisation for Health Research and Development (ZonMw 40–00812-98–11010). The study sponsors had no role in study design, data analysis, interpretation of data, or writing of this report. BAMSE: We acknowledge all funding sources: The Swedish Research Council, The Swedish Heart and Lung Foundation, The Swedish Research Council for Working Life and Social Welfare, the Swedish Asthma and Allergy Association Research Foundation, The Swedish Research Council Formas, Stockholm County Council, and the European Commission’s Seventh Framework 29 Program Me DALL under grant agreement No.261357. We thank all the children and their parents for participating in the BAMSE cohort and the nurses and other staff members working in the BAMSE project. EDEN: We acknowledge all the funding sources for the EDEN study: Foundation for medical research (FRM), National Agency for Research (ANR), National Institute for Research in Public health (IRESP: TGIR cohorte santé 2008 program), French Ministry of Health (DGS), French Ministry of Research, INSERM Bone and Joint Diseases National Research (PRO-A) and Human Nutrition National Research Programs, Paris–Sud University, Nestlé, French National Institute for Population Health Surveillance (InVS),French National Institute for Health Education (INPES), the European Union FP7programmes (FP7/2007-2013, HELIX, ESCAPE, ENRIECO, Medall projects), Diabetes National Research Program (through a collaboration with the French Association of Diabetic Patients (AFD)), French Agency for Environmental Health Safety (now ANSES), Mutuelle Générale de l’Education Nationale a complementary health insurance (MGEN),French national agency for food security, French speaking association for the study ofdiabetes and metabolism (ALFEDIAM).We acknowledge the commitment of the EDEN mother-child cohort study group: I.Annesi-Maesano, JY. Bernard, J. Botton, M.A. Charles, P. Dargent-Molina, B. de Lauzon-Guillain, P. Ducimetière, M. de Agostini, B. Foliguet, , A. Forhan, X. Fritel, A. Germa, V.Goua, R. Hankard, B. Heude, M. Kaminski, B. Larroque†, N. Lelong, J. Lepeule, G.Magnin, L. Marchand, C. Nabet, F. Pierre, R. Slama, M.J. Saurel-Cubizolles, M.Schweitzer, O. Thiebaugeorges.The Generation R Study:The Generation R study is made possible by financial support from the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam, the Netherlands Organization for Health Research and Development (ZonMw), the Netherlands Organisation for Scientific Research (NWO), the Ministry of Health, Welfareand Sport and the Ministry of Youth and Families. The project received funding from the European Union's Horizon 2020 research and innovation programme (LIFECYCLE project, grant agreement no 733206; 2016), the European Research Council (ERC-2014-CoG-648916) and from cofunded ERA-Net on Biomarkers for Nutrition and Health (ERAHDHL), Horizon 2020 (grant agreement no 696295; 2017), ZonMW The Netherlands (no529051014; 2017), Science Foundation Ireland (no SFI/16/ERA-HDHL/3360), and the European Union (ALPHABET project).The researchers are independent from the funders. The study sponsors had no role in study design, data analysis, interpretation of data, or writing of this report. INMA: Data used for this research was provided by the INMA-Environment and Childhood Project (www.proyectoinma.org). This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176 and CB06/02/0041), Spanish Ministry of Health (FIS-PIO41436, PI06/0867, PI081151, and FIS-FEDER 03/1615, 04/1112,04/1931, 05/1079, 05/1052, 06/1213, 07/0314 and 09/02647), Generalitat de Catalunya-CIRIT 1999SGR00241, the Conselleria de Sanitat Generalitat Valenciana, Department of Health of the Basque Government (2005111093 and 2009111069), the ProvincialGovernment of Gipuzkoa (DFG06/004 and DFG08/001).KOALA: The collection of the data from the KOALA Birth Cohort Study used in this analysis was financially supported by Friesland Foods (now Friesland Campina),Netherlands Asthma Foundation (grant numbers 3.2.07.022 and 3.2.03.48), Netherlands Heart Foundation (grant number 2014 T037, the Netherlands Organization for Health Research and Development (Zon Mw Prevention Program number 1.210-00-090), Triodos Foundation, Phoenix Foundation, Raphaël Foundation, Iona Foundation, Foundation forthe Advancement of Heilpedagogie, all in the Netherlands. MAS:The MAS birth cohort was funded by grants from the German Federal Ministry ofEducation and Research (BMBF; reference numbers 07015633, 07 ALE 27, 01EE9405/5,01EE9406) and the German Research Foundation (DFG; reference number KE 1462/2-1).PIAMA: The PIAMA study has been funded by The Netherlands Organisation for Health Research and Development; The Netherlands Organisation for Scientific Research; The Netherlands Asthma fund; The Netherlands Ministry of Spatial Planning Housing, and the Environment; and The Netherlands Ministry of Health, Welfare and Sport. RHEA: The Rhea project was financially supported by European projects (EU FP6-003-Food-3-NewGeneris -Contract No16320, EU FP6 STREP Hiwate -Contract No36224,EU FP7 ENV.2007.1.2.2.2. Project No 211250 Escape, EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers Contract No226756, EU FP7-HEALTH-2009-single stage CHICOS Contract No241604, EU FP7 ENV.2008.1.2.1.6. Proposal No 226285 ENRIECO, EU-FP7,Proposal No 264357 MeDALL, EU- FP7-HEALTH-2012 Proposal No 308333 HELIX),and the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece:2011-2014; “Rhea Plus”: Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012-2015).ROBBIC: Data of the Rome cohort was in part supported byfunds from the Italian Ministry of Health (Programma speciale ex art. 12, comma 2, lettera b) del D. Lgs. 502/92,2001, 2003). We thank all the fields workers and the families for their contribution to thestudy. SWS: We thank the members of the Southampton Women's Survey Study group and the many participants in the SWS for their contribution to the study. The Southampton Women’s Survey is supported by grants from the Medical Research Council, British Heart Foundation, Food Standards Agency, British Lung Foundation, Arthritis Research UK, NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, and the European Union's Seventh Framework Programme (FP7/2007-2013), project Early Nutrition under grant agreement n°289346.
Published: 2018

36. Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis.

Author: Eijkemans M, Mommers M, Harskamp-van Ginkel MW, Vrijkotte TGM, Ludvigsson J, Faresjö Å, Bergström A, Ekström S, Grote V, Koletzko B, Bønnelykke K, Eliasen AU, Bager P, Melbye M, Annesi-Maesano I, Baïz N, Barros H, Santos AC, Duijts L, Mensink-Bout SM, Flexeder C, Koletzko S, Schikowski T, Eggesbø MÅ, Lenters V, Fernández-Tardón G, Subiza-Perez M, Garcia-Aymerich J, López-Vicente M, Sunyer J, Torrent M, Ballester F, Kelleher C, Mehegan J, Berg AV, Herberth G, Standl M, Kuehni CE, Pedersen ESL, Jansen M, Gehring U, Boer JMA, Devereux G, Turner S, Peltola V, Lagström H, Inskip HM, Pike KC, Dalmeijer GW, Ent CKV, and Thijs C
Subjects: Humans, Child, Adolescent, Male, Child, Preschool, Europe epidemiology, Female, Infant, Accelerometry, Longitudinal Studies, Surveys and Questionnaires, Forced Expiratory Volume, Spirometry, Infant, Newborn, Vital Capacity, Birth Cohort, Asthma epidemiology, Asthma physiopathology, Sedentary Behavior, Exercise
Abstract: Objectives: To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study., Design: Pooling of longitudinal data from collaborating birth cohorts using meta-analysis of separate cohort-specific estimates and analysis of individual participant data of all cohorts combined., Setting: Children aged 0-18 years from 26 European birth cohorts., Participants: 136 071 individual children from 26 cohorts, with information on PA and/or sedentary behaviour in early childhood and asthma assessment in later childhood., Main Outcome Measure: Questionnaire-based current asthma and lung function measured by spirometry (forced expiratory volume in 1 s (FEV 1 ), FEV 1 /forced vital capacity) at age 6-18 years., Results: Questionnaire-based and accelerometry-based PA and sedentary behaviour at age 3-5 years was not associated with asthma at age 6-18 years (PA in hours/day adjusted OR 1.01, 95% CI 0.98 to 1.04; sedentary behaviour in hours/day adjusted OR 1.03, 95% CI 0.99 to 1.07). PA was not associated with lung function at any age. Analyses of sedentary behaviour and lung function showed inconsistent results., Conclusions: Reduced PA and increased sedentary behaviour before 6 years of age were not associated with the presence of asthma later in childhood., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Published: 2024
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37. [Digital media use and sleep of adolescents: the effect of rules at home].

Author: de Poot S, Harskamp-van Ginkel MW, and Vrijkotte TGM
Subjects: Child, Female, Humans, Adolescent, Male, Cross-Sectional Studies, Parents, Surveys and Questionnaires, Internet, Sleep
Abstract: Objective: To test whether parental rules regarding the amount of digital media use is associated with the sleep of Dutch adolescents, and whether this is indirectly due to lower digital media use., Design: Cross-sectional study METHOD: Adolescents and their parents of the Amsterdam Born Children and their Development (ABCD) study completed questionnaires in 2019 at the age of 15-16 years (n=1369; 56% girls). Parents and adolescents reported whether there are rules regarding the amount of digital media use. The adolescents also reported their daily amount of digital media use, sleep duration, bedtime and sleep quality according to the Pittsburgh Sleep Quality Index (PSQI). We tested the association between rules and sleep duration, bedtime and sleep quality in adolescents using multivariate regression analysis. Using mediation analysis we tested whether rules were also indirectly associated with sleep outcome measures through the amount of digital media use., Results: Setting rules regarding digital media use was related to sleep duration; 6.8 minutes (95%CI:0.1;13.5) longer with inconsistently experienced rules and 18.5 minutes (95%CI:9.2;27.8) longer with consistently existing rules. Setting rules was also related to bedtime; 10 minutes (95%CI: -17;-4) earlier with inconsistently experienced rules and 29 minutes (95%CI:-38;-2) earlier with consistently existing rules. Setting rules was not directly associated with sleep quality. Indirectly, rules were associated with longer sleep duration, earlier bedtime and better sleep quality due to lower digital media use per day., Conclusion: Parental rules regarding the amount of digital media use is associated with better sleep of adolescents. This is partly explained by lower digital media use.
Published: 2022

38. Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood.

Author: Elhakeem A, Taylor AE, Inskip HM, Huang J, Tafflet M, Vinther JL, Asta F, Erkamp JS, Gagliardi L, Guerlich K, Halliday J, Harskamp-van Ginkel MW, He JR, Jaddoe VWV, Lewis S, Maher GM, Manios Y, Mansell T, McCarthy FP, McDonald SW, Medda E, Nisticò L, de Moira AP, Popovic M, Reiss IKM, Rodrigues C, Salika T, Smith A, Stazi MA, Walker C, Wu M, Åsvold BO, Barros H, Brescianini S, Burgner D, Chan JKY, Charles MA, Eriksson JG, Gaillard R, Grote V, Håberg SE, Heude B, Koletzko B, Morton S, Moschonis G, Murray D, O'Mahony D, Porta D, Qiu X, Richiardi L, Rusconi F, Saffery R, Tough SC, Vrijkotte TGM, Nelson SM, Nybo Andersen AM, Magnus MC, and Lawlor DA
Subjects: Adolescent, Adult, Child, Child, Preschool, Cohort Studies, Embryo Transfer methods, Female, Humans, Infant, Male, Obesity epidemiology, Pregnancy, Reproductive Techniques, Assisted adverse effects, Adiposity, Semen
Abstract: Importance: People conceived using assisted reproductive technology (ART) make up an increasing proportion of the world's population., Objective: To investigate the association of ART conception with offspring growth and adiposity from infancy to early adulthood in a large multicohort study., Design, Setting, and Participants: This cohort study used a prespecified coordinated analysis across 26 European, Asia-Pacific, and North American population-based cohort studies that included people born between 1984 and 2018, with mean ages at assessment of growth and adiposity outcomes from 0.6 months to 27.4 years. Data were analyzed between November 2019 and February 2022., Exposures: Conception by ART (mostly in vitro fertilization, intracytoplasmic sperm injection, and embryo transfer) vs natural conception (NC; without any medically assisted reproduction)., Main Outcomes and Measures: The main outcomes were length / height, weight, and body mass index (BMI; calculated as weight in kilograms divided by height in meters squared). Each cohort was analyzed separately with adjustment for maternal BMI, age, smoking, education, parity, and ethnicity and offspring sex and age. Results were combined in random effects meta-analysis for 13 age groups., Results: Up to 158 066 offspring (4329 conceived by ART) were included in each age-group meta-analysis, with between 47.6% to 60.6% females in each cohort. Compared with offspring who were NC, offspring conceived via ART were shorter, lighter, and thinner from infancy to early adolescence, with differences largest at the youngest ages and attenuating with older child age. For example, adjusted mean differences in offspring weight were -0.27 (95% CI, -0.39 to -0.16) SD units at age younger than 3 months, -0.16 (95% CI, -0.22 to -0.09) SD units at age 17 to 23 months, -0.07 (95% CI, -0.10 to -0.04) SD units at age 6 to 9 years, and -0.02 (95% CI, -0.15 to 0.12) SD units at age 14 to 17 years. Smaller offspring size was limited to individuals conceived by fresh but not frozen embryo transfer compared with those who were NC (eg, difference in weight at age 4 to 5 years was -0.14 [95% CI, -0.20 to -0.07] SD units for fresh embryo transfer vs NC and 0.00 [95% CI, -0.15 to 0.15] SD units for frozen embryo transfer vs NC). More marked differences were seen for body fat measurements, and there was imprecise evidence that offspring conceived by ART developed greater adiposity by early adulthood (eg, ART vs NC difference in fat mass index at age older than 17 years: 0.23 [95% CI, -0.04 to 0.50] SD units)., Conclusions and Relevance: These findings suggest that people conceiving or conceived by ART can be reassured that differences in early growth and adiposity are small and no longer evident by late adolescence.
Published: 2022
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