31 results on '"Harsch, Andreas"'
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2. 54020 Potent and selective TYK2 degraders, devoid of JAK activity, potently and completely suppress IL12/23 and IFN-a signaling pathways.
3. 53901 Potent and selective oral STAT6 degraders inhibit IL-4 and IL-13 functions in human cells and block TH2 inflammation in a mouse model of atopic dermatitis
4. Tu1488 POTENT AND SELECTIVE ORAL STAT6 DEGRADERS INHIBIT IL-4 AND IL-13 FUNCTIONS IUN HUMAN CELLS AND BLOCK TH2 INFLAMMATION IN VIVO IN A MOUSE MODEL
5. Direct determination of the ratio of unbound fraction in plasma to unbound fraction in microsomal system ( fup/ fumic) for refined prediction of phase I mediated metabolic hepatic clearance
6. Interfacing of CE in a PVP matrix to ion trap mass spectrometry: analysis of isometric and structurally-related (N-acetylamino)fluorene-modified oligonucleotides
7. Analysis of the in vitro digestion of modified DNA to oligonucleotides by LC–MS and LC–MS/MS
8. Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors
9. MARK inhibitors: Declaring a No-Go decision on a chemical series based on extensive DMPK experimentation
10. Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors
11. Analysis of DNA adducts using high-performance separation techniques coupled to electrospray ionization mass spectrometry
12. Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor
13. Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2)
14. Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization
15. SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2)
16. Phenylglycine and phenylalanine derivatives as potent and selective HDAC 1inhibitors (SHI-1)
17. Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2)
18. Direct determination of the ratio of unbound fraction in plasma to unbound fraction in microsomal system (fup/fumic) for refined prediction of phase I mediated metabolic hepatic clearance
19. Abstract 5433: Prolonged histone hyperacetylation with a novel class of HDAC1/2 selective inhibitors
20. Design of novel histone deacetylase inhibitors
21. The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors
22. Phenylglycine and phenylalanine derivatives as potent and selective HDAC1 inhibitors (SHI-1)
23. Identification of Novel Metabolites of Colchicine in Rat Bile Facilitated by Enhanced Online Radiometric Detection
24. A 13C NMR approach to categorizing potential limitations of α,β-unsaturated carbonyl systems in drug-like molecules
25. HPLC−MS/MS Identification of Positionally Isomeric Benzo[c]phenanthrene Diol Epoxide Adducts in Duplex DNA
26. Oligonucleotide sequencing using guanine-specific methylation and electrospray ionization ion trap mass spectrometry
27. Sequence-Specific Photomodification of DNA by an Oligonucleotide-Phenanthrodihydrodioxin Conjugate
28. Direct determination of the ratio of unbound fraction in plasma to unbound fraction in microsomal system (fu p/fu mic) for refined prediction of phase I mediated metabolic hepatic clearance
29. Accurate and rapid modeling of iron–bleomycin-induced DNA damage using tethered duplex oligonucleotides and electrospray ionization ion trap mass spectrometric analysis.
30. A 13C NMR approach to categorizing potential limitations of α,β-unsaturated carbonyl systems in drug-like molecules
31. A 13C NMR approach to categorizing potential limitations of alpha,beta-unsaturated carbonyl systems in drug-like molecules.
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