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11. Serotonin release by parachloroamphetamine in rats with high and low sociability: High prefrontal release capacity in sociable females.

Author

Norden, Marianna, Kanarik, Margus, Laugus, Karita, O'Leary, Aet, Liiver, Kristi, Tõnissaar, Margus, Shimmo, Ruth, and Harro, Jaanus

Subjects
SOCIAL anxiety, LABORATORY rats, PREFRONTAL cortex, SOCIAL interaction, SOCIABILITY
Abstract

Background: Social behaviour is the expression of one of the most generally accepted independent dimensions of personality. Serotonergic neurotransmission has been implicated in typical social response and drugs that promote serotonin (5-hydroxytryptamine (5-HT)) release have prosocial effects. By using the social interaction test, we have previously demonstrated sociability as a temperamental trait in male Wistar rats. Aims: To assess sociability in male rats of the Sprague–Dawley strain and in female rats of both Wistar and Sprague–Dawley strain, and extracellular levels of 5-HT in rats with high and low sociability (high sociability (HS)- and low sociability (LS)-rats). Methods: Social interaction test conducted with different weight-matched partners was used to assess sociability, and in vivo, microdialysis was performed before and after administration of a low dose (2 mg/kg) of parachloroamphetamine (PCA) in the prefrontal cortex, dorsamedial striatum and ventral tegmental area. Results: Similarly to male Wistar rats, female Wistars and Sprague–Dawley rats of both sexes displayed trait-wise sociability. Male Wistar HS-rats had lower extracellular levels of 5-HT in prefrontal cortex at baseline and after administration of PCA, and higher PCA-induced increase of extracellular 5-HT in ventral tegmental area. In dorsomedial striatum, PCA elicited a comparable increase in extracellular dopamine in HS- and LS-rats, but higher release of 5-HT in HS-rats. Comparison of PCA-induced 5-HT release in prefrontal cortex of male and female Sprague–Dawley rats revealed a larger 5-HT response in female HS-rats. Conclusions: 5-HT release potential is higher in rats with high expression of sociability trait, whereas some regionally variable differences may be related to relative contributions of social motivation and anxiety in shaping social behaviour. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Changes in national rates of psychiatric beds and incarceration in Central Eastern Europe and Central Asia from 1990-2019: A retrospective database analysis

Author

Mundt, Adrian P, Rozas Serri, Enzo, Siebenförcher, Mathias, Alikaj, Valbona, Ismayilov, Fuad, Razvodovsky, Yury E, Hasanovic, Mevludin, Marinov, Petar, Frančišković, Tanja, Cermakova, Pavla, Harro, Jaanus, Sulaberidze, Lela, Kalapos, Miklós Péter, Assimov, Marat, Nurmagambetova, Saltanat, Ibishi, Nazmie F, Molchanova, Elena, Taube, Māris, Chihai, Jana, Dedovic, Jovo, Gosek, Paweł, Tataru, Nicoleta, Golenkov, Andrei, Lecic-Tosevski, Dusica, Randjelovic, Dunja, Izakova, Lubomira, Švab, Vesna, Vohidova, Mutabara, Kerimi, Nina, Sukhovii, Oleksii, and Priebe, Stefan

Published
2021
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35. Effect of RNA m6A methyltransferase activation by a low molecular weight compound on anxiety- and depression-related behaviours, monoamine neurochemistry and striatal gene expression in the rat

Author

Kanarik, Margus, primary, Liiver, Kristi, additional, Skolnaja, Marianna, additional, Teino, Indrek, additional, Org, Tonis, additional, Laugus, Karita, additional, Shimmo, Ruth, additional, Karelson, Mati, additional, Saarma, Mart, additional, and Harro, Jaanus, additional

Published
2024
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38. Genome-wide DNA methylation analysis of aggressive behaviour: a longitudinal population-based study

Author

Pishva, Ehsan, van den Hove, Daniel L. A., Laroche, Valentin, Lvovs, Aneth, Roy, Arunima, Ortega, Gabriela, Burrage, Joe, Veidebaum, Toomas, Kanarik, Margus, Mill, Jonathan, Lesch, Klaus‐Peter, Harro, Jaanus, Basic Neuroscience 1, RS: MHeNs - R3 - Neuroscience, and Psychiatrie & Neuropsychologie

Subjects
DNA methylation, SYMPTOMS, epigenetics, MEN, ASSOCIATION, GENETIC RISK, MAJOR HISTOCOMPATIBILITY COMPLEX, Aggression, MATE CHOICE, Psychiatry and Mental health, Pediatrics, Perinatology and Child Health, Developmental and Educational Psychology, genetics, IMPULSIVITY, LOW-CHOLESTEROL
Abstract

BackgroundHuman aggression is influenced by an interplay between genetic predisposition and experience across the life span. This interaction is thought to occur through epigenetic mechanisms, inducing differential gene expression, thereby moderating neuronal cell and circuit function, and thus shaping aggressive behaviour. MethodsGenome-wide DNA methylation (DNAm) levels were measured in peripheral blood obtained from 95 individuals participating in the Estonian Children Personality Behaviours and Health Study (ECPBHS) at 15 and 25 years of age. We examined the association between aggressive behaviour, as measured by Life History of Aggression (LHA) total score and DNAm levels both assessed at age 25. We further examined the pleiotropic effect of genetic variants regulating LHA-associated differentially methylated positions (DMPs) and multiple traits related to aggressive behaviours. Lastly, we tested whether the DNA methylomic loci identified in association with LHA at age 25 were also present at age 15. ResultsWe found one differentially methylated position (DMP) (cg17815886; p = 1.12 x 10(-8)) and five differentially methylated regions (DMRs) associated with LHA after multiple testing adjustments. The DMP annotated to the PDLIM5 gene, and DMRs resided in the vicinity of four protein-encoding genes (TRIM10, GTF2H4, SLC45A4, B3GALT4) and a long intergenic non-coding RNA (LINC02068). We observed evidence for the colocalization of genetic variants associated with top DMPs and general cognitive function, educational attainment and cholesterol levels. Notably, a subset of the DMPs associated with LHA at age 25 also displayed altered DNAm patterns at age 15 with high accuracy in predicting aggression. ConclusionsOur findings highlight the potential role of DNAm in the development of aggressive behaviours. We observed pleiotropic genetic variants associated with identified DMPs, and various traits previously established to be relevant in shaping aggression in humans. The concordance of DNAm signatures in adolescents and young adults may have predictive value for inappropriate and maladaptive aggression later in life.

Published
2023

49. Neuropeptide Y gene variants and Agreeableness: interaction effect with the birth cohort and the serotonin transporter promoter polymorphism.

Author

Kiive, Evelyn, Kanarik, Margus, Veidebaum, Toomas, and Harro, Jaanus

Subjects
NEUROPEPTIDE Y, SEROTONIN transporters, COHORT analysis, GENETIC variation, AGREEABLENESS
Abstract

Objective: Neuropeptide Y (NPY) is a powerful regulator of anxious states, including social anxiety, but evidence from human genetic studies is limited. Associations of common gene variants with behaviour have been described as subject to birth cohort effects, especially if the behaviour is socially motivated. This study aimed to examine the association of NPY rs16147 and rs5574 with personality traits in highly representative samples of two birth cohorts of young adults, the samples having been formed during a period of rapid societal transition. Methods: Both birth cohorts (original n = 1238) of the Estonian Children Personality Behaviour and Health Study (ECPBHS) self-reported personality traits of the five-factor model at 25 years of age. Results: A significant interaction effect of the NPY rs16147 and rs5574 and birth cohort on Agreeableness was found. The T/T genotype of NPY rs16147 resulted in low Agreeableness in the older cohort (born 1983) and in high Agreeableness in the younger cohort (born 1989). The C/C genotype of NPY rs5574 was associated with higher Agreeableness in the younger but not in the older cohort. In the NPY rs16147 T/T homozygotes, the deviations from average in Agreeableness within the birth cohort were dependent on the serotonin transporter promoter polymorphism. Conclusions: The association between the NPY gene variants and a personality domain reflecting social desirability is subject to change qualitatively in times of rapid societal changes, serving as an example of the relationship between the plasticity genes and environment. The underlying mechanism may involve the development of the serotonergic system. [ABSTRACT FROM AUTHOR]

Published
2024
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50. A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders

Author

Rozenblat, Vanja, Ong, Deborah, Fuller-Tyszkiewicz, Matthew, Akkermann, Kirsti, Collier, David, Engels, Rutger C.M.E., Fernandez-Aranda, Fernando, Harro, Jaanus, Homberg, Judith R., Karwautz, Andreas, Kiive, Evelyn, Klump, Kelly L., Larson, Christine L., Racine, Sarah E., Richardson, Jodie, Steiger, Howard, Stoltenberg, Scott F., van Strien, Tatjana, Wagner, Gudrun, Treasure, Janet, and Krug, Isabel

Published
2017
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