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1. Canadian Alliance for Healthy Hearts and Minds: First Nations Cohort Study Rationale and Design

Author

Anand, Sonia S., Abonyi, Sylvia, Arbour, Laura, Brook, Jeff, Bruce, Sharon, Castleden, Heather, Desai, Dipika, de Souza, Russell J., Harris, Stewart, Irvine, James, Lai, Christopher, Lewis, Diana, Oster, Richard T, Poirier, Paul, Toth, Ellen L., Bannon, Karen, Chrisjohn, Vicky, Davis, Albertha D., L'Hommecourt, Jean, Littlechild, Randy, McMullin, Kathleen, McIntosh, Sarah, Morrison, Julie, Picard, Manon, Landing First Nation, Pictou, M. Thomas, Melissa, Tusevljak, Natasa, Friedrich, Matthias G., and Tu, Jack V.

Published
2018
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10. In the watchdoghouse

Author

Harris, Stewart

Subjects
AUDITING, WASTE IN GOVERNMENT, FRAUD, INSPECTOR GENERAL - Defense Dept
Abstract

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Published
1990

15. Overview of the Dark Energy Spectroscopic Instrument

Author

Martini, Paul, Bailey, Stephen, Besuner, Robert W., Brooks, David, Doel, Peter, Edelstein, Jerry, Eisenstein, Daniel, Flaugher, Brenna, Gutierrez, Gaston, Harris, Stewart E., Honscheid, Klaus, Jelinsky, Patrick, Joyce, Richard, Kent, Stephen, Levi, Michael, Prada, Francisco, Poppett, Claire, Rabinowitz, David, Rockosi, Constance, Sas, Laia Cardiel, Schlegel, David J., Schubnell, Michael, Sharples, Ray, Silber, Joseph H., Sprayberry, David, and Wechsler, Risa

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Dark Energy Spectroscopic Instrument (DESI) is under construction to measure the expansion history of the Universe using the Baryon Acoustic Oscillation technique. The spectra of 35 million galaxies and quasars over 14000 square degrees will be measured during the life of the experiment. A new prime focus corrector for the KPNO Mayall telescope will deliver light to 5000 fiber optic positioners. The fibers in turn feed ten broad-band spectrographs. We present an overview of the instrumentation, the main technical requirements and challenges, and the current status of the project., Comment: 11 pages, 4 figures

Published
2018
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19. Evaluating remission of type 2 diabetes using a metabolic intervention including fixed‐ratio insulin degludec and liraglutide: A randomized controlled trial.

Author

Punthakee, Zubin, Hall, Stephanie, McInnes, Natalia, Sherifali, Diana, Tsiplova, Kate, Kirabo, Faith R., Ransom, Thomas P. P., Harris, Stewart B., Lochnan, Heather A., Sigal, Ronald J., Ghosh, Mahua, Spaic, Tamara, and Gerstein, Hertzel C.

Subjects
TYPE 2 diabetes, EXERCISE therapy, EXECUTIVE coaching, DISEASE remission, BODY mass index
Abstract

Aim: To evaluate the effect on type 2 diabetes remission of short‐term intensive metabolic intervention consisting of frequent dietary, exercise and diabetes management coaching, metformin and fixed‐ratio insulin degludec/liraglutide. Methods: In a multicentre open‐label randomized controlled trial, insulin‐naïve participants within 5 years of diabetes diagnosis were assigned to a 16‐week remission intervention regimen or standard care, and followed for relapse of diabetes and sustained remission for an additional year after stopping glucose‐lowering drugs. Results: A total of 159 participants aged 57 ± 10 years, with diabetes duration 2.6 ± 1.5 years, body mass index 33.5 ± 6.5 kg/m2, and glycated haemoglobin (HbA1c) level 53 ± 7 mmol/mol were randomized and analysed (79 intervention, 80 control). At the end of the 16‐week intervention period, compared to controls, intervention participants achieved lower HbA1c levels (40 ± 4 vs. 51 ± 7 mmol/mol; p < 0.0001), and lost more weight (3.3 ± 4.4% vs. 1.9 ± 3.0%; p = 0.02). There was a lower hazard of diabetes relapse overall in the intervention group compared to controls (hazard ratio 0.63, 95% confidence interval [CI] 0.45, 0.88; p = 0.007), although this was not sustained over time. Remission rates in the intervention group were not significantly higher than in the control group at 12 weeks (17.7% vs. 12.5%, relative risk [RR] 1.42, 95% CI 0.67, 3.00; p = 0.36) or at 52 weeks (6.3% vs. 3.8%, RR 1.69, 95% CI 0.42, 6.82) following the intervention period. Conclusions: An intensive remission‐induction intervention including fixed‐ratio insulin degludec/liraglutide reduced the risk of type 2 diabetes relapse within 1 year without sustained remission. [ABSTRACT FROM AUTHOR]

Published
2024
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20. A Glycemic Threshold Above Which the Improvement of β-Cell Function and Glycemia in Response to Insulin Therapy Is Amplified in Early Type 2 Diabetes: The Reversal of Glucotoxicity.

Author

Retnakaran, Ravi, Pu, Jiajie, Ye, Chang, Emery, Alexandra, Harris, Stewart B., Reichert, Sonja M., Gerstein, Hertzel C., McInnes, Natalia, Kramer, Caroline K., and Zinman, Bernard

Subjects
GLUCOSE tolerance tests, TYPE 2 diabetes, INSULIN therapy, GLUCOSE, FUNCTIONAL assessment
Abstract

OBJECTIVE: Alleviation of unrecognized glucotoxicity, with resultant recovery of β-cell function, could amplify the glucose-lowering effect of pharmacotherapy and contribute to the variable therapeutic response observed among patients with type 2 diabetes (T2D). However, clinical evidence supporting this concept is lacking. Short-term intensive insulin therapy (IIT) can ameliorate glucotoxicity and improve β-cell function in early T2D. Thus, for evidence of recovery of glucotoxicity-associated β-cell dysfunction, we sought to determine whether there exists a baseline fasting glucose threshold above which the post-IIT improvement in both β-cell function and glycemia is amplified. RESEARCH DESIGN AND METHODS: IIT (glargine, lispro) was administered for 3 weeks to 108 adults with T2D (mean duration 1.8 ± 1.4 years). Oral glucose tolerance tests before and after IIT enabled assessment of β-cell function by Insulin Secretion-Sensitivity Index-2 and insulinogenic index/HOMA-insulin resistance. For each level of baseline fasting glycemia from 6.0 to 10.5 mmol/L, we modeled the difference in IIT-induced percentage change in β-cell function between those at/above the indicated glucose level and those below it. RESULTS: The relationship between baseline fasting glucose and the differential change in β-cell function was nonlinear. Instead, this relationship was best fit by a cubic regression model with inflection (amplification) at fasting glucose at 9.3 mmol/L. Moreover, baseline fasting glucose at 9.3 mmol/L also identified the inflection point at which nonlinear reductions in fasting glucose and 2-h glucose, respectively, were both amplified. CONCLUSIONS: The respective improvements in β-cell function and glycemia in response to short-term IIT are amplified in those in whom baseline fasting glucose exceeds a defined threshold, consistent with reversal of glucotoxicity. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Evaluation of a unique and innovative diabetes care model in primary care in Ontario, Canada: protocol for a multiple-methods study with a convergent parallel design

Author

Mathews, Maria, primary, Lyons, Rhiannon, additional, Harris, Stewart, additional, Hedden, Lindsay, additional, Choi, Yun-Hee, additional, Donnan, Jennifer, additional, Green, Michael E, additional, Harvey, Elisabeth, additional, Reichert, Sonja M., additional, Ryan, Bridget, additional, Sibbald, Shannon, additional, and Meredith, Leslie, additional

Published
2024
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23. Surveillance du glucose en continu

Author

Harris, Stewart B., Bari, Basel, and Gilbert, Jeremy

Subjects
Boehringer Ingelheim GmbH, AstraZeneca PLC, Eli Lilly and Co., Novo Nordisk A/S, Sanofi S.A., Dextrose, Glucose, Type 2 diabetes, Health
Abstract

1 La surveillance du glucose en continu (SGC) chez les personnes diabetiques ameliore l'evolution de l'etat de sante de ces dernieres et favorise leur autoprise en charge Comparativement aux verifications [...]

Published
2024
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26. Flood of bad bolts

Author

Harris, Stewart

Subjects
FASTENERS, FRAUD
Abstract

illus chart

Published
1987

31. The DEDUCE Model, A Cost-Utility Tool Using Patient-Level Microsimulation to Evaluate Sensor-Based Glucose Monitoring Systems in Type 1 and Type 2 Diabetes: Comparative Validation

Author

Szafranski, Kirk, primary, De Pouvourville, Gerard, additional, Greenberg, Dan, additional, Harris, Stewart, additional, Jendle, Johan, additional, Shaw, Jonathan E., additional, Coaquira Castro, JeanPierre, additional, Poon, Yeesha, additional, and Levrat-Guillen, Fleur, additional

Published
2024
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34. Explaining the variability in cardiovascular risk factors among First Nations communities in Canada: a population-based study

Author

Anand, Sonia S, Abonyi, Sylvia, Arbour, Laura, Balasubramanian, Kumar, Brook, Jeffrey, Castleden, Heather, Chrisjohn, Vicky, Cornelius, Ida, Davis, Albertha Darlene, Desai, Dipika, de Souza, Russell J, Friedrich, Matthias G, Harris, Stewart, Irvine, James, L'Hommecourt, Jean, Littlechild, Randy, Mayotte, Lisa, McIntosh, Sarah, Morrison, Julie, Oster, Richard T, Picard, Manon, Poirier, Paul, Schulze, Karleen M, and Toth, Ellen L

Published
2019
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50. A Qualitative Enquiry of Hypoglycemia and the Social Determinants of Health: The InHypo-DM Study, Canada

Author

Brown, Judith Belle, Reichert, Sonja M., Valliere, Yashoda, Webster-Bogaert, Susan, Ratzki-Leewing, Alexandria, and Harris, Stewart B.

Subjects
Diabetes mellitus -- Complications and side effects -- Social aspects -- Care and treatment -- Research, Family medicine -- Usage -- Research, Hypoglycemia -- Risk factors -- Social aspects -- Care and treatment -- Research, Family and marriage, Health, Psychology and mental health
Abstract

Introduction: A significant body of research exists on the impact of the social determinants of health (SDoHs) on diabetes care and general health outcomes. However, less is known about health care practitioners' (HCPs') perspectives and experiences regarding the impact of the SDoHs on their patients with Type I and Type 2 diabetes mellitus and how this affects the prevention and treatment of hypoglycemia. Method: A descriptive qualitative study, derived from the InHypo-DM (Canada) research program. A purposive sampling technique was used to recruit participants residing in southwestern Ontario, Canada, for a 30- to 45-min semistructured interview. Individual and team analysis of interviews was conducted to identify overarching and subthemes. Twenty HCP participants, including endocrinologists, family physicians, and allied health care practitioners, were recruited. Seven were Certified Diabetes Educators. Results: Participants articulated 2 overarching components of the SDoHs: patients' socioeconomic issues and psychosocial issues. They highlighted two socioeconomic issues: occupation type and poverty. Participants also emphasized 3 areas pertaining to patients' psychosocial issues: stage in the life cycle (e.g., elderly), social isolation, and mental health. Discussion: This study emphasizes the need for conducting detailed and comprehensive social histories during clinical diabetes assessments, as well as the necessity of adequate clinical time and resources for HCPs and patients to address these issues in the context of hypoglycemia management.Keywords: hypoglycemia, diabetes mellitus, social determinants of health, health care practitioners, qualitative research, Evidence suggests that traditional approaches to glycemic management that focus solely on blood glucose targets are insufficient at reducing rates of hypoglycemia (Goodall & Halford, 1991; Peyrot et al., 2005). [...]

Published
2018
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