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4. HUMAN IMMUNE RESPONSE TO A XENOGENEIC NUCLEATED CELL

Author

Harris, Jules E., Hersh, Evan M., and Huggins, Sara

Abstract

Four normal human subjects were immunized with alligator erythrocytes. The development of in vitro lymphocyte blastogenesis and humoral antibody to these cells was followed at serial intervals after immunization. Humoral antibody was not detected in preimmunization samples of serum. Significant in vitro lymphocyte blastogenesis to alligator erythrocytes was seen with all four subjects prior to immunization. This reaction represented either a primary immune response in vitro or an example of antigenic cross reactivity. Following immunization, there was a rapid increase in the blastogenic response. This effect was noted before antibody was detected in the serum and persisted long after antibody could no longer be measured. There was, however, a correlation between antibody formation and in vitro lymphocyte blastogenesis. It is concluded that in vitro lymphocyte blastogenesis is a more sensitive index for both the development and the persistence of an immune response to a xenogeneic cell than is the measurement of humoral antibody.

Published
2023

25. The treatment of cancer in an aging population

Author

Harris, Jules E.

Subjects
Cancer -- Care and treatment, Aged -- Diseases
Abstract

Cancer is primarily a disease of the elderly, and the US population is aging. By the year 2010, 14% of all Americans will be 65 or older, and half of all cancer occurs in this group. Older individuals experience a decline in organ function that was thought to make them more susceptible to the side effects of chemotherapy. For this reason, they were often excluded from chemotherapy trials. But a recent study of women receiving chemotherapy for advanced breast cancer found that the women over 70 had the same response, disease progression and survival as the younger women. They suffered no more side effects than the younger women. Elderly cancer patients should not be excluded from treatment protocols simply because of their age. Elderly patients may develop blood cell deficiencies more often than younger patients after chemotherapy, but they can be given naturally-occurring substances that boost blood cell production.

Published
1992

36. Phase II Study of Mitoguazone, Cyclophosphamide, Doxorubicin, Vincristine and Prednisone for Patients with Diffuse Histologic Subtypes of Non-Hodgkin's Lymphoma: An Eastern Cooperative Oncology Group Study (PE481)

Author

Wiernik, Peter H., primary, Moore, Dirk F., additional, Bennett, John M., additional, Vogl, Steven E., additional, Harris, Jules E., additional, Luger, Selina, additional, Oken, Martin M., additional, and Glick, John H., additional

Published
1998
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