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2. Prevalence of iron deficiency in 62,685 women of seven race/ethnicity groups: The HEIRS Study

Author

Barton, James C, Wiener, Howard H, Acton, Ronald T, Adams, Paul C, Eckfeldt, John H, Gordeuk, Victor R, Harris, Emily L, McLaren, Christine E, Harrison, Helen, McLaren, Gordon D, and Reboussin, David M

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Human Society, Prevention, Brain Disorders, Adult, Aged, Anemia, Iron-Deficiency, Canada, Cross-Sectional Studies, Ethnicity, Female, Ferritins, Hemochromatosis Protein, Humans, Middle Aged, Mutation, Prevalence, Transferrin, United States, General Science & Technology
Abstract

BackgroundFew cross-sectional studies report iron deficiency (ID) prevalence in women of different race/ethnicity and ages in US or Canada.Materials and methodsWe evaluated screening observations on women who participated between 2001-2003 in a cross-sectional, primary care-based sample of adults ages ≥25 y whose observations were complete: race/ethnicity; age; transferrin saturation; serum ferritin; and HFE p.C282Y and p.H63D alleles. We defined ID using a stringent criterion: combined transferrin saturation

Published
2020

4. Dietary iron intake and serum ferritin concentration in 213 patients homozygous for the HFEC282Y hemochromatosis mutation

Author

Gordeuk, Victor R, Lovato, Laura, Barton, James C, Vitolins, Mara, McLaren, Gordon, Acton, Ronald T, McLaren, Christine, Harris, Emily L, Speechley, Mark, Eckfeldt, John H, Diaz, Sharmin, Sholinsky, Phyliss, and Adams, Paul

Abstract

BACKGROUND: HFEC282Y homozygotes have an increased risk for developing increased iron stores and related disorders. It is controversial whether dietary iron restrictions should be recommended to such individuals. OBJECTIVE: To determine whether dietary iron content influences iron stores in HFEC282Y homozygotes as assessed by serum ferritin concentration. DESIGN: Serum ferritin concentration was measured and a dietary iron questionnaire was completed as part of the evaluation of 213 HFEC282Y homozygotes who were identified through screening of >100,000 primary care patients at five HEmochromatosis and IRon Overload Screening (HEIRS) Study Field Centers in the United States and Canada. RESULTS: No significant relationships between serum ferritin concentration and dietary heme iron content, dietary nonheme iron content or reports of supplemental iron use were found. CONCLUSION: These results do not support recommending dietary heme or nonheme iron restrictions for HFEC282Y homozygotes diagnosed through screening in North America.

Published
2012

6. Specificity of Clinical Breast Examination in Community Practice

Author

Fenton, Joshua J, Rolnick, Sharon J, Harris, Emily L, Barton, Mary B, Barlow, William E, Reisch, Lisa M, Herrinton, Lisa J, Geiger, Ann M, Fletcher, Suzanne W, and Elmore, Joann G

Subjects
Cancer, Prevention, Health Services, Clinical Trials and Supportive Activities, Clinical Research, Breast Cancer, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Adult, Aged, Breast Neoplasms, Cohort Studies, Community Health Services, Female, Humans, Mass Screening, Middle Aged, Physical Examination, Physicians, Retrospective Studies, Sensitivity and Specificity, breast cancer, sensitivity and specificity, screening, physical examination, Clinical Sciences, General & Internal Medicine
Abstract

BackgroundMillions of women receive clinical breast examination (CBE) each year, as either a breast cancer screening test or a diagnostic test for breast symptoms. While screening CBE had moderately high specificity (approximately 94%) in clinical trials, community clinicians may be comparatively inexperienced and may conduct relatively brief examinations, resulting in even higher specificity but lower sensitivity.ObjectiveTo estimate the specificity of screening and diagnostic CBE in clinical practice and identify patient factors associated with specificity.DesignRetrospective cohort study.SubjectsBreast-cancer-free female health plan enrollees in 5 states (WA, OR, CA, MA, and MN) who received CBE (N = 1,484).MeasurementsMedical charts were abstracted to ascertain breast cancer risk factors, examination purpose (screening vs diagnostic), and results (true-negative vs false-positive). Women were considered "average-risk" if they had neither a family history of breast cancer nor a prior breast biopsy and "increased-risk" otherwise.ResultsAmong average- and increased-risk women, respectively, the specificity (true-negative proportion) of screening CBE was 99.4% [95% confidence interval (CI): 98.8-99.7%] and 97.1% (95% CI: 95.7-98.0%), and the specificity of diagnostic CBE was 68.7% (95% CI: 59.7-76.5%) and 57.1% (95% CI: 51.1-63.0%). The odds of a true-negative screening CBE (specificity) were significantly lower among women at increased risk of breast cancer (adjusted odds ratio 0.21; 95% CI: 0.10-0.46).ConclusionsScreening CBE likely has higher specificity among community clinicians compared to examiners in clinical trials of breast cancer screening, even among women at increased breast cancer risk. Highly specific examinations, however, may have relatively low sensitivity for breast cancer. Diagnostic CBE, meanwhile, is relatively nonspecific.

Published
2007

7. Hemochromatosis and Iron-Overload Screening in a Racially Diverse Population

Author

Adams, Paul C, Reboussin, David M, Barton, James C, McLaren, Christine E, Eckfeldt, John H, McLaren, Gordon D, Dawkins, Fitzroy W, Acton, Ronald T, Harris, Emily L, Gordeuk, Victor R, Leiendecker-Foster, Catherine, Speechley, Mark, Snively, Beverly M, Holup, Joan L, Thomson, Elizabeth, and Sholinsky, Phyliss

Subjects
Prevention, Digestive Diseases, Clinical Research, Genetics, Chronic Liver Disease and Cirrhosis, Liver Disease, Hematology, Arthritis, Diabetes Complications, Female, Ferritins, Gene Frequency, Genotype, Heart Diseases, Hemochromatosis, Hemochromatosis Protein, Histocompatibility Antigens Class I, Homozygote, Humans, Iron, Iron Overload, Liver Diseases, Logistic Models, Male, Membrane Proteins, Mutation, Phenotype, Sex Distribution, Transferrin, United States, Hemochromatosis and Iron Overload Screening (HEIRS) Study Research Investigators, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundIron overload and hemochromatosis are common, treatable conditions. HFE genotypes, levels of serum ferritin, transferrin saturation values, and self-reported medical history were studied in a multiethnic primary care population.MethodsParticipants were recruited from primary care practices and blood-drawing laboratories. Blood samples were tested for transferrin saturation, serum ferritin, and C282Y and H63D mutations of the HFE gene. Before genetic screening, participants were asked whether they had a history of medical conditions related to iron overload.ResultsOf the 99,711 participants, 299 were homozygous for the C282Y mutation. The estimated prevalence of C282Y homozygotes was higher in non-Hispanic whites (0.44 percent) than in Native Americans (0.11 percent), Hispanics (0.027 percent), blacks (0.014 percent), Pacific Islanders (0.012 percent), or Asians (0.000039 percent). Among participants who were homozygous for the C282Y mutation but in whom iron overload had not been diagnosed (227 participants), serum ferritin levels were greater than 300 mug per liter in 78 of 89 men (88 percent) and greater than 200 microg per liter in 79 of 138 women (57 percent). Pacific Islanders and Asians had the highest geometric mean levels of serum ferritin and mean transferrin saturation despite having the lowest prevalence of C282Y homozygotes. There were 364 participants in whom iron overload had not been diagnosed (29 C282Y homozygotes) who had a serum ferritin level greater than 1000 microg per liter. Among men, C282Y homozygotes and compound heterozygotes were more likely to report a history of liver disease than were participants without HFE mutations.ConclusionsThe C282Y mutation is most common in whites, and most C282Y homozygotes have elevations in serum ferritin levels and transferrin saturation. The C282Y mutation does not account for high mean serum ferritin levels and transferrin saturation values in nonwhites.

Published
2005

8. Higher risk of multiple falls among elderly women who lose visual acuity

Author

Coleman, Anne L, Stone, Katie, Ewing, Susan K, Nevitt, Michael, Cummings, Steven, Cauley, Jane A, Ensrud, Kristine E, Harris, Emily L, Hochberg, Marc C, and Mangione, Carol M

Subjects
Clinical Trials and Supportive Activities, Clinical Research, Eye Disease and Disorders of Vision, Prevention, Aging, Eye, Accidental Falls, Aged, Female, Fractures, Bone, Frail Elderly, Health Status Indicators, Humans, Odds Ratio, Prospective Studies, Risk Factors, Vision Disorders, Visual Acuity, Women's Health, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry
Abstract

ObjectiveTo determine the association between changes in visual acuity (VA) and frequent falls in older women.DesignProspective cohort study.ParticipantsTwo thousand two elderly community-residing women participating in the Study of Osteoporotic Fractures with measurements of VA at baseline and a follow-up examination 4 to 6 years later (mean of 5.6 years).MethodsBinocular VA with habitual correction was measured under standard illumination using Bailey-Lovie charts at baseline and fourth examinations. Change in VA was stratified into 5 categories: no change or VA gain, loss of 1 to 5 letters, loss of 6 to 10 letters, loss of 11 to 15 letters, and loss of >15 letters. A separate analysis considered decline in VA as the loss of >or=10 letters (>or=2 lines) on the Bailey-Lovie acuity measure between baseline and follow-up examinations.Main outcome measuresData on falls were obtained from postcards sent every 4 months after the follow-up examination. Frequent falling was defined as >or=2 falls during a 1-year period after the follow-up examination.ResultsCompared with women with stable or improved VA, women with declining acuity had significantly greater odds of experiencing frequent falling during the subsequent year. Odds ratios after adjustment for baseline acuity and other confounders were 2.08 (95% confidence interval [CI]: 1.39-3.12) for loss of 1 to 5 letters, 1.85 (95% CI: 1.16-2.95) for loss of 6 to 10 letters, 2.51 (95% CI: 1.39-4.52) for loss of 11 to 15 letters, and 2.08 (95% CI: 1.01-4.30) for loss of >15 letters. In the analysis of visual decline defined as a loss of >or=10 letters, heightened risk of frequent falling was evident in each of 2 subgroups defined by splitting the sample on baseline VA, with borderline significant evidence of a more pronounced effect in those women with baseline VA of 20/40 or worse (P value for interaction, 0.083).ConclusionsLoss of vision among elderly women increases the risk of frequent falls. Prevention or correction of visual loss may help reduce the number of future falls.

Published
2004

11. Bivariate mixture modeling of transferrin saturation and serum ferritin concentration in Asians, African Americans, Hispanics, and whites in the Hemochromatosis and Iron Overload Screening (HEIRS) Study

Author

McLaren, Christine E., Gordeuk, Victor R., Chen, Wen-Pin, Barton, James C., Acton, Ronald T., Speechley, Mark, Castro, Oswaldo, Adams, Paul C., Snively, Beverly M., Harris, Emily L., Reboussin, David M., McLachlan, Geoffrey J., and Bean, Richard

Published
2008
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14. Replicating genotype-phenotype associations

Author

Chanock, Stephen J., Manolio, Teri, Boehnke, Michael, Boerwinkle, Eric, Hunter, David J., Thomas, Gilles, Hirschhorn, Joel N., Abecasis, Goncalo, Altshuler, David, Bailey-Wilson, Joan E., Brooks, Lisa D., Cardon, Lon R., Daly, Mark, Donnelly, Peter, Fraumeni, Jr, Joseph F., Freimer, Nelson B., Gerhard, Daniela S., Gunter, Chris, Guttmacher, Alan E., Guyer, Mark S., Harris, Emily L., Hoh, Josephine, Hoover, Robert, Kong, C. Augustine, Merikangas, Kathleen R., Morton, Cynthia C., Palmer, Lyle J., Phimister, Elizabeth G., Rice, John P., Roberts, Jerry, Rotimi, Charles, Tucker, Margaret A., Vogan, Kyle J., Wacholder, Sholom, Wijsman, Ellen M., Winn, Deborah M., and Collins, Francis S.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): NCI-NHGRI Working Group on Replication in Association Studies; Stephen J. Chanock (corresponding author) [1, 2]; Teri Manolio (corresponding author) [3]; Michael Boehnke [4]; Eric Boerwinkle [5]; David J. Hunter [...]

Published
2007
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19. A framework for human microbiome research

Author

Methé, Barbara A., Nelson, Karen E., Pop, Mihai, Creasy, Heather H., Giglio, Michelle G., Huttenhower, Curtis, Gevers, Dirk, Petrosino, Joseph F., Abubucker, Sahar, Badger, Jonathan H., Chinwalla, Asif T., Earl, Ashlee M., FitzGerald, Michael G., Fulton, Robert S., Hallsworth-Pepin, Kymberlie, Lobos, Elizabeth A., Madupu, Ramana, Magrini, Vincent, Martin, John C., Mitreva, Makedonka, Muzny, Donna M., Sodergren, Erica J., Versalovic, James, Wollam, Aye M., Worley, Kim C., Wortman, Jennifer R., Young, Sarah K., Zeng, Qiandong, Aagaard, Kjersti M., Abolude, Olukemi O., Allen-Vercoe, Emma, Alm, Eric J., Alvarado, Lucia, Andersen, Gary L., Anderson, Scott, Appelbaum, Elizabeth, Arachchi, Harindra M., Armitage, Gary, Arze, Cesar A., Ayvaz, Tulin, Baker, Carl C., Begg, Lisa, Belachew, Tsegahiwot, Bhonagiri, Veena, Bihan, Monika, Blaser, Martin J., Bloom, Toby, Bonazzi, Vivien R., Brooks, Paul, Buck, Gregory A., Buhay, Christian J., Busam, Dana A., Campbell, Joseph L., Canon, Shane R., Cantarel, Brandi L., Chain, Patrick S., Chen, I-Min A., Chen, Lei, Chhibba, Shaila, Chu, Ken, Ciulla, Dawn M., Clemente, Jose C., Clifton, Sandra W., Conlan, Sean, Crabtree, Jonathan, Cutting, Mary A., Davidovics, Noam J., Davis, Catherine C., DeSantis, Todd Z., Deal, Carolyn, Delehaunty, Kimberley D., Dewhirst, Floyd E., Deych, Elena, Ding, Yan, Dooling, David J., Dugan, Shannon P., Dunne, Michael W., Jr, Durkin, Scott A., Edgar, Robert C., Erlich, Rachel L., Farmer, Candace N., Farrell, Ruth M., Faust, Karoline, Feldgarden, Michael, Felix, Victor M., Fisher, Sheila, Fodor, Anthony A., Forney, Larry, Foster, Leslie, Di Francesco, Valentina, Friedman, Jonathan, Friedrich, Dennis C., Fronick, Catrina C., Fulton, Lucinda L., Gao, Hongyu, Garcia, Nathalia, Giannoukos, Georgia, Giblin, Christina, Giovanni, Maria Y., Goldberg, Jonathan M., Goll, Johannes, Gonzalez, Antonio, Griggs, Allison, Gujja, Sharvari, Haas, Brian J., Hamilton, Holli A., Harris, Emily L., Hepburn, Theresa A., Herter, Brandi, Hoffmann, Diane E., Holder, Michael E., Howarth, Clinton, Huang, Katherine H., Huse, Susan M., Izard, Jacques, Jansson, Janet K., Jiang, Huaiyang, Jordan, Catherine, Joshi, Vandita, Katancik, James A., Keitel, Wendy A., Kelley, Scott T., Kells, Cristyn, Kinder-Haake, Susan, King, Nicholas B., Knight, Rob, Knights, Dan, Kong, Heidi H., Koren, Omry, Koren, Sergey, Kota, Karthik C., Kovar, Christie L., Kyrpides, Nikos C., La Rosa, Patricio S., Lee, Sandra L., Lemon, Katherine P., Lennon, Niall, Lewis, Cecil M., Lewis, Lora, Ley, Ruth E., Li, Kelvin, Liolios, Konstantinos, Liu, Bo, Liu, Yue, Lo, Chien-Chi, Lozupone, Catherine A., Lunsford, Dwayne R., Madden, Tessa, Mahurkar, Anup A., Mannon, Peter J., Mardis, Elaine R., Markowitz, Victor M., Mavrommatis, Konstantinos, McCorrison, Jamison M., McDonald, Daniel, McEwen, Jean, McGuire, Amy L., McInnes, Pamela, Mehta, Teena, Mihindukulasuriya, Kathie A., Miller, Jason R., Minx, Patrick J., Newsham, Irene, Nusbaum, Chad, O’Laughlin, Michelle, Orvis, Joshua, Pagani, Ioanna, Palaniappan, Krishna, Patel, Shital M., Pearson, Matthew, Peterson, Jane, Podar, Mircea, Pohl, Craig, Pollard, Katherine S., Priest, Margaret E., Proctor, Lita M., Qin, Xiang, Raes, Jeroen, Ravel, Jacques, Reid, Jeffrey G., Rho, Mina, Rhodes, Rosamond, Riehle, Kevin P., Rivera, Maria C., Rodriguez-Mueller, Beltran, Rogers, Yu-Hui, Ross, Matthew C., Russ, Carsten, Sanka, Ravi K., Sankar, Pamela, Sathirapongsasuti, Fah J., Schloss, Jeffery A., Schloss, Patrick D., Schmidt, Thomas M., Scholz, Matthew, Schriml, Lynn, Schubert, Alyxandria M., Segata, Nicola, Segre, Julia A., Shannon, William D., Sharp, Richard R., Sharpton, Thomas J., Shenoy, Narmada, Sheth, Nihar U., Simone, Gina A., Singh, Indresh, Smillie, Chris S., Sobel, Jack D., Sommer, Daniel D., Spicer, Paul, Sutton, Granger G., Sykes, Sean M., Tabbaa, Diana G., Thiagarajan, Mathangi, Tomlinson, Chad M., Torralba, Manolito, Treangen, Todd J., Truty, Rebecca M., Vishnivetskaya, Tatiana A., Walker, Jason, Wang, Lu, Wang, Zhengyuan, Ward, Doyle V., Warren, Wesley, Watson, Mark A., Wellington, Christopher, Wetterstrand, Kris A., White, James R., Wilczek-Boney, Katarzyna, Wu, Yuan Qing, Wylie, Kristine M., Wylie, Todd, Yandava, Chandri, Ye, Liang, Ye, Yuzhen, Yooseph, Shibu, Youmans, Bonnie P., Zhang, Lan, Zhou, Yanjiao, Zhu, Yiming, Zoloth, Laurie, Zucker, Jeremy D., Birren, Bruce W., Gibbs, Richard A., Highlander, Sarah K., Weinstock, George M., Wilson, Richard K., and White, Owen

Published
2012
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20. Structure, function and diversity of the healthy human microbiome

Author

Huttenhower, Curtis, Gevers, Dirk, Knight, Rob, Abubucker, Sahar, Badger, Jonathan H., Chinwalla, Asif T., Creasy, Heather H., Earl, Ashlee M., FitzGerald, Michael G., Fulton, Robert S., Giglio, Michelle G., Hallsworth-Pepin, Kymberlie, Lobos, Elizabeth A., Madupu, Ramana, Magrini, Vincent, Martin, John C., Mitreva, Makedonka, Muzny, Donna M., Sodergren, Erica J., Versalovic, James, Wollam, Aye M., Worley, Kim C., Wortman, Jennifer R., Young, Sarah K., Zeng, Qiandong, Aagaard, Kjersti M., Abolude, Olukemi O., Allen-Vercoe, Emma, Alm, Eric J., Alvarado, Lucia, Andersen, Gary L., Anderson, Scott, Appelbaum, Elizabeth, Arachchi, Harindra M., Armitage, Gary, Arze, Cesar A., Ayvaz, Tulin, Baker, Carl C., Begg, Lisa, Belachew, Tsegahiwot, Bhonagiri, Veena, Bihan, Monika, Blaser, Martin J., Bloom, Toby, Bonazzi, Vivien, Brooks, Paul J., Buck, Gregory A., Buhay, Christian J., Busam, Dana A., Campbell, Joseph L., Canon, Shane R., Cantarel, Brandi L., Chain, Patrick S. G., Chen, I-Min A., Chen, Lei, Chhibba, Shaila, Chu, Ken, Ciulla, Dawn M., Clemente, Jose C., Clifton, Sandra W., Conlan, Sean, Crabtree, Jonathan, Cutting, Mary A., Davidovics, Noam J., Davis, Catherine C., DeSantis, Todd Z., Deal, Carolyn, Delehaunty, Kimberley D., Dewhirst, Floyd E., Deych, Elena, Ding, Yan, Dooling, David J., Dugan, Shannon P., Dunne, Wm Michael, Durkin, Scott A., Edgar, Robert C., Erlich, Rachel L., Farmer, Candace N., Farrell, Ruth M., Faust, Karoline, Feldgarden, Michael, Felix, Victor M., Fisher, Sheila, Fodor, Anthony A., Forney, Larry J., Foster, Leslie, Di Francesco, Valentina, Friedman, Jonathan, Friedrich, Dennis C., Fronick, Catrina C., Fulton, Lucinda L., Gao, Hongyu, Garcia, Nathalia, Giannoukos, Georgia, Giblin, Christina, Giovanni, Maria Y., Goldberg, Jonathan M., Goll, Johannes, Gonzalez, Antonio, Griggs, Allison, Gujja, Sharvari, Haake, Susan Kinder, Haas, Brian J., Hamilton, Holli A., Harris, Emily L., Hepburn, Theresa A., Herter, Brandi, Hoffmann, Diane E., Holder, Michael E., Howarth, Clinton, Huang, Katherine H., Huse, Susan M., Izard, Jacques, Jansson, Janet K., Jiang, Huaiyang, Jordan, Catherine, Joshi, Vandita, Katancik, James A., Keitel, Wendy A., Kelley, Scott T., Kells, Cristyn, King, Nicholas B., Knights, Dan, Kong, Heidi H., Koren, Omry, Koren, Sergey, Kota, Karthik C., Kovar, Christie L., Kyrpides, Nikos C., La Rosa, Patricio S., Lee, Sandra L., Lemon, Katherine P., Lennon, Niall, Lewis, Cecil M., Lewis, Lora, Ley, Ruth E., Li, Kelvin, Liolios, Konstantinos, Liu, Bo, Liu, Yue, Lo, Chien-Chi, Lozupone, Catherine A., Lunsford, Dwayne R., Madden, Tessa, Mahurkar, Anup A., Mannon, Peter J., Mardis, Elaine R., Markowitz, Victor M., Mavromatis, Konstantinos, McCorrison, Jamison M., McDonald, Daniel, McEwen, Jean, McGuire, Amy L., McInnes, Pamela, Mehta, Teena, Mihindukulasuriya, Kathie A., Miller, Jason R., Minx, Patrick J., Newsham, Irene, Nusbaum, Chad, O’Laughlin, Michelle, Orvis, Joshua, Pagani, Ioanna, Palaniappan, Krishna, Patel, Shital M., Pearson, Matthew, Peterson, Jane, Podar, Mircea, Pohl, Craig, Pollard, Katherine S., Pop, Mihai, Priest, Margaret E., Proctor, Lita M., Qin, Xiang, Raes, Jeroen, Ravel, Jacques, Reid, Jeffrey G., Rho, Mina, Rhodes, Rosamond, Riehle, Kevin P., Rivera, Maria C., Rodriguez-Mueller, Beltran, Rogers, Yu-Hui, Ross, Matthew C., Russ, Carsten, Sanka, Ravi K., Sankar, Pamela, Sathirapongsasuti, Fah J., Schloss, Jeffery A., Schloss, Patrick D., Schmidt, Thomas M., Scholz, Matthew, Schriml, Lynn, Schubert, Alyxandria M., Segata, Nicola, Segre, Julia A., Shannon, William D., Sharp, Richard R., Sharpton, Thomas J., Shenoy, Narmada, Sheth, Nihar U., Simone, Gina A., Singh, Indresh, Smillie, Christopher S., Sobel, Jack D., Sommer, Daniel D., Spicer, Paul, Sutton, Granger G., Sykes, Sean M., Tabbaa, Diana G., Thiagarajan, Mathangi, Tomlinson, Chad M., Torralba, Manolito, Treangen, Todd J., Truty, Rebecca M., Vishnivetskaya, Tatiana A., Walker, Jason, Wang, Lu, Wang, Zhengyuan, Ward, Doyle V., Warren, Wesley, Watson, Mark A., Wellington, Christopher, Wetterstrand, Kris A., White, James R., Wilczek-Boney, Katarzyna, Wu, YuanQing, Wylie, Kristine M., Wylie, Todd, Yandava, Chandri, Ye, Liang, Ye, Yuzhen, Yooseph, Shibu, Youmans, Bonnie P., Zhang, Lan, Zhou, Yanjiao, Zhu, Yiming, Zoloth, Laurie, Zucker, Jeremy D., Birren, Bruce W., Gibbs, Richard A., Highlander, Sarah K., Methé, Barbara A., Nelson, Karen E., Petrosino, Joseph F., Weinstock, George M., Wilson, Richard K., and White, Owen

Published
2012
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25. Serum Ferritin and Transferrin Saturation in Asians and Pacific Islanders

Author

Harris, Emily L., McLaren, Christine E., Reboussin, David M., Gordeuk, Victor R., Barton, James C., Acton, Ronald T., McLaren, Gordon D., Vogt, Thomas M., Snively, Beverly M., Leiendecker-Foster, Catherine, Holup, Joan L., Passmore, Leah V., Eckfeldt, John H., Lin, Edward, and Adams, Paul C.

Published
2007

42. African Americans at Risk for Increased Iron Stores or Liver Disease

Author

Dawkins, Fitzroy W., Gordeuk, Victor R., Snively, Beverly M., Lovato, Laura, Barton, James C., Acton, Ronald T., McLaren, Gordon D., Leiendecker-Foster, Catherine, McLaren, Christine E., Adams, Paul C., Speechley, Mark, Harris, Emily L., Jackson, Sharon, and Thomson, Elizabeth J.

Subjects
Iron in the body -- Research, Iron in the body -- Health aspects, Liver diseases -- Research, Liver diseases -- Risk factors, African Americans -- Health aspects, African Americans -- Research, Transferrin -- Research, Health, Health care industry
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.amjmed.2006.05.049 Byline: Fitzroy W. Dawkins (a), Victor R. Gordeuk (a), Beverly M. Snively (b), Laura Lovato (b), James C. Barton (c), Ronald T. Acton (d), Gordon D. McLaren (e), Catherine Leiendecker-Foster (f), Christine E. McLaren (g), Paul C. Adams (h), Mark Speechley (h), Emily L. Harris (i), Sharon Jackson (b), Elizabeth J. Thomson (j) Keywords: African Americans; Serum ferritin; Transferrin saturation; HFE; Liver disease; Increased iron stores Abstract: We sought to determine the prevalence of elevated measures of iron status in African Americans and whether the combination of serum ferritin concentration >200 [mu]g/L for women or >300 [mu]g/L for men and transferrin saturation in the highest quartile represents increased likelihood of mutation of HFE, self-reported iron overload or self-reported liver disease. Author Affiliation: (a) Division of Hematology/Oncology, Department of Medicine, Howard University, Washington, DC (b) Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC (c) Southern Iron Disorders Center, Birmingham, Ala (d) Departments of Microbiology, Medicine, and Epidemiology and International Health, University of Alabama at Birmingham, Birmingham, Ala (e) Division of Hematology/Oncology, Department of Medicine, University of California, Irvine and Veterans Affairs Long Beach Healthcare System, Long Beach (f) Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis (g) Epidemiology Division, Department of Medicine, University of California, Irvine (h) Department of Medicine, London Health Sciences Center, London, Ontario, Canada (i) Kaiser Permanente Center for Health Research, Portland, Ore (j) National Human Genome Research Institute, Bethesda, Md. Article Note: (footnote) The HEIRS Study was initiated and funded by NHLBI, in conjunction with NHGRI. The study is supported by contracts N01-HC-05185 (University of Minnesota), N01-HC-05186 (Howard University), N01-HC-05188 (University of Alabama at Birmingham), N01-HC-05189 (Kaiser Permanente Center for Health Research), N01-HC-05190 (University of California, Irvine), N01-HC-05191 (London Health Sciences Centre), and N01-HC-05192 (Wake Forest University). Additional support was provided by grant UH1-HL03679-07 from NHLBI and the Office of Minority Health, and by General Clinical Research Center (GCRC) grants to Howard University (M01-RR10284), University of California, Irvine (5M01RR 00827-29) and University of Alabama at Birmingham (M01-RR00032), sponsored by the National Center for Research Resources, National Institutes of Health (NCRR/NIH).

Published
2007

43. Next Generation Analytic Tools for Large Scale Genetic Epidemiology Studies of Complex Diseases

Author

Mechanic, Leah E., Chen, Huann-Sheng, Amos, Christopher I., Chatterjee, Nilanjan, Cox, Nancy J., Divi, Rao L., Fan, Ruzong, Harris, Emily L., Jacobs, Kevin, Kraft, Peter, Leal, Suzanne M., McAllister, Kimberly, Moore, Jason H., Paltoo, Dina N., Province, Michael A., Ramos, Erin M., Ritchie, Marylyn D., Roeder, Kathryn, Schaid, Daniel J., Stephens, Matthew, Thomas, Duncan C., Weinberg, Clarice R., Witte, John S., Zhang, Shunpu, Zöllner, Sebastian, Feuer, Eric J., and Gillanders, Elizabeth M.

Subjects
Article
Abstract

Over the past several years, genome-wide association studies (GWAS) have succeeded in identifying hundreds of genetic markers associated with common diseases. However, most of these markers confer relatively small increments of risk and explain only a small proportion of familial clustering. To identify obstacles to future progress in genetic epidemiology research and provide recommendations to NIH for overcoming these barriers, the National Cancer Institute sponsored a workshop entitled “Next Generation Analytic Tools for Large-Scale Genetic Epidemiology Studies of Complex Diseases” on September 15–16, 2010. The goal of the workshop was to facilitate discussions on (1) statistical strategies and methods to efficiently identify genetic and environmental factors contributing to the risk of complex disease; and (2) how to develop, apply, and evaluate these strategies for the design, analysis, and interpretation of large-scale complex disease association studies in order to guide NIH in setting the future agenda in this area of research. The workshop was organized as a series of short presentations covering scientific (gene-gene and gene-environment interaction, complex phenotypes, and rare variants and next generation sequencing) and methodological (simulation modeling and computational resources and data management) topic areas. Specific needs to advance the field were identified during each session and are summarized.

Published
2011

44. Screening for Iron Overload: Lessons from the HEmochromatosis and IRon Overload Screening (HEIRS) Study

Author

Adams, Paul C, Barton, James C, McLaren, Gordon D, Acton, Ronald T, Speechley, Mark, McLaren, Christine E, Reboussin, David M, Leiendecker-Foster, Catherine, Harris, Emily L, Snively, Beverly M, Vogt, Thomas, Sholinsky, Phyliss, Thomson, Elizabeth, Dawkins, Fitzroy W, Gordeuk, Victor R, and Eckfeldt, John H

Subjects
Article Subject
Abstract

BACKGROUND: The HEmochromatosis and IRon Overload Screening (HEIRS) Study provided data on a racially, ethnically and geographically diverse cohort of participants in North America screened from primary care populations.METHODS: A total of 101,168 participants were screened by testing for HFE C282Y and H63D mutations, and measuring serum ferritin concentration and transferrin saturation. In the present review, lessons from the HEIRS Study are highlighted in the context of the principles of screening for a medical disease as previously outlined by the World Health Organization.RESULTS: Genetic testing is well accepted, with minimal risk of discrimination. Transferrin saturation has high biological variability and relatively low sensitivity to detect HFE C282Y homozygotes, which limits its role as a screening test. Symptoms attributable to HFE C282Y homozygosity are no more common in individuals identified by population screening than in control subjects.CONCLUSIONS: Generalized population screening in a primary care population as performed in the HEIRS Study is not recommended. There may be a role for focused screening in Caucasian men, with some debate regarding genotyping followed by phenotyping, or phenotyping followed by genotyping.

Published
2009
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46. A Mechanism for Controlled Access to GWAS Data: Experience of the GAIN Data Access Committee

Author

Ramos, Erin M., primary, Din-Lovinescu, Corina, additional, Bookman, Ebony B., additional, McNeil, Lisa J., additional, Baker, Carl C., additional, Godynskiy, Georgy, additional, Harris, Emily L., additional, Lehner, Thomas, additional, McKeon, Catherine, additional, Moss, Joel, additional, Starks, Vaurice L., additional, Sherry, Stephen T., additional, Manolio, Teri A., additional, and Rodriguez, Laura Lyman, additional

Published
2013
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47. Dietary Iron Intake and Serum Ferritin Concentration in 213 Patients Homozygous for theHFEC282YHemochromatosis Mutation

Author

Gordeuk, Victor R, primary, Lovato, Laura, additional, Barton, James C, additional, Vitolins, Mara, additional, McLaren, Gordon, additional, Acton, Ronald T, additional, McLaren, Christine, additional, Harris, Emily L, additional, Speechley, Mark, additional, Eckfeldt, John H, additional, Diaz, Sharmin, additional, Sholinsky, Phyliss, additional, and Adams, Paul, additional

Published
2012
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48. Next generation analytic tools for large scale genetic epidemiology studies of complex diseases

Author

Mechanic, Leah E., primary, Chen, Huann‐Sheng, additional, Amos, Christopher I., additional, Chatterjee, Nilanjan, additional, Cox, Nancy J., additional, Divi, Rao L., additional, Fan, Ruzong, additional, Harris, Emily L., additional, Jacobs, Kevin, additional, Kraft, Peter, additional, Leal, Suzanne M., additional, McAllister, Kimberly, additional, Moore, Jason H., additional, Paltoo, Dina N., additional, Province, Michael A., additional, Ramos, Erin M., additional, Ritchie, Marylyn D., additional, Roeder, Kathryn, additional, Schaid, Daniel J., additional, Stephens, Matthew, additional, Thomas, Duncan C., additional, Weinberg, Clarice R., additional, Witte, John S., additional, Zhang, Shunpu, additional, Zöllner, Sebastian, additional, Feuer, Eric J., additional, and Gillanders, Elizabeth M., additional

Published
2011
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50. The gene, environment association studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions

Author

Cornelis, Marilyn C., primary, Agrawal, Arpana, additional, Cole, John W., additional, Hansel, Nadia N., additional, Barnes, Kathleen C., additional, Beaty, Terri H., additional, Bennett, Siiri N., additional, Bierut, Laura J., additional, Boerwinkle, Eric, additional, Doheny, Kimberly F., additional, Feenstra, Bjarke, additional, Feingold, Eleanor, additional, Fornage, Myriam, additional, Haiman, Christopher A., additional, Harris, Emily L., additional, Hayes, M. Geoffrey, additional, Heit, John A., additional, Hu, Frank B., additional, Kang, Jae H., additional, Laurie, Cathy C., additional, Ling, Hua, additional, Manolio, Teri A., additional, Marazita, Mary L., additional, Mathias, Rasika A., additional, Mirel, Daniel B., additional, Paschall, Justin, additional, Pasquale, Louis R., additional, Pugh, Elizabeth W., additional, Rice, John P., additional, Udren, Jenna, additional, van Dam, Rob M., additional, Wang, Xiaojing, additional, Wiggs, Janey L., additional, Williams, Kayleen, additional, and Yu, Kai, additional

Published
2010
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