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Your search keyword '"Harré Hindmarsh, Jennie"' showing total 26 results
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26 results on '"Harré Hindmarsh, Jennie"'

14. Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand

Author

Krishnan, Mohanraj, Major, Tanya J., Topless, Ruth K., Dewes, Ofa, Yu, Lennex, Thompson, John M. D., McCowan, Lesley, de Zoysa, Janak, Stamp, Lisa K., Dalbeth, Nicola, Harré Hindmarsh, Jennie, Rapana, Nuku, Deka, Ranjan, Eng, Winston W. H., Weeks, Daniel E., Minster, Ryan L., McGarvey, Stephen T., Viali, Satupa’itea, Naseri, Take, Sefuiva Reupena, Muagututi’a, Wilcox, Phillip, Grattan, David, Shepherd, Peter R., Shelling, Andrew N., Murphy, Rinki, and Merriman, Tony R.

Published
2018
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15. Multivariate analysis of a missense variant in CREBRF reveals associations with measures of adiposity in people of Polynesian ancestries

Author

Zhang, Jerry Z., primary, Heinsberg, Lacey W., additional, Krishnan, Mohanraj, additional, Hawley, Nicola L., additional, Major, Tanya J., additional, Carlson, Jenna C., additional, Harré Hindmarsh, Jennie, additional, Watson, Huti, additional, Qasim, Muhammad, additional, Stamp, Lisa K., additional, Dalbeth, Nicola, additional, Murphy, Rinki, additional, Sun, Guangyun, additional, Cheng, Hong, additional, Naseri, Take, additional, Reupena, Muagututi'a S., additional, Kershaw, Erin E., additional, Deka, Ranjan, additional, McGarvey, Stephen T., additional, Minster, Ryan L., additional, Merriman, Tony R., additional, and Weeks, Daniel E., additional

Published
2022
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16. Multivariate analysis of a missense variant inCREBRFreveals associations with measures of adiposity in people of Polynesian ancestries

Author

Zhang, Jerry Z., primary, Heinsberg, Lacey W., additional, Krishnan, Mohanraj, additional, Hawley, Nicola L., additional, Major, Tanya J., additional, Carlson, Jenna C., additional, Harré Hindmarsh, Jennie, additional, Watson, Huti, additional, Qasim, Muhammad, additional, Stamp, Lisa K., additional, Dalbeth, Nicola, additional, Murphy, Rinki, additional, Sun, Guangyun, additional, Cheng, Hong, additional, Naseri, Take, additional, Reupena, Muagututi’a S., additional, Kershaw, Erin E., additional, Deka, Ranjan, additional, McGarvey, Stephen T., additional, Minster, Ryan L., additional, Merriman, Tony R., additional, and Weeks, Daniel E., additional

Published
2022
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17. Multivariate analysis of a missense variant in CREBRF reveals associations with measures of adiposity in people of Polynesian ancestries.

Author

Zhang, Jerry Z., Heinsberg, Lacey W., Krishnan, Mohanraj, Hawley, Nicola L., Major, Tanya J., Carlson, Jenna C., Harré Hindmarsh, Jennie, Watson, Huti, Qasim, Muhammad, Stamp, Lisa K., Dalbeth, Nicola, Murphy, Rinki, Sun, Guangyun, Cheng, Hong, Naseri, Take, Reupena, Muagututi'a S., Kershaw, Erin E., Deka, Ranjan, McGarvey, Stephen T., and Minster, Ryan L.

Published
2023
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19. Randomised cross-over trial of vildagliptin and pioglitazone as add-on therapy in patients with type 2 diabetes: predicting Which One is Right Here (WORTH) study protocol

Author

Yeu, Rui Qian, primary, Brandon, Rebecca, additional, Jiang, Yannan, additional, Griffiths, Dale, additional, Smallman, Kate, additional, Moffitt, Allan, additional, Doherty, Glenn, additional, Paul, Ryan, additional, Harré Hindmarsh, Jennie, additional, Merriman, Tony R, additional, Macaskill-Smith, Kerry, additional, Orr-Walker, Brandon, additional, and Murphy, Rinki, additional

Published
2020
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22. Genomic medicine must reduce, not compound, health inequities: the case for hauora-enhancing genomic resources for New Zealand.

Author

Robertson, Stephen P., Harré Hindmarsh, Jennie, Berry, Sarah, Cameron, Vicky A., Cox, Murray P., Dewes, Ofa, Doughty, Robert N., Gray, George, Jacobsen, Jessie C., Laurence, Albert, Matisoo-Smith, Elizabeth, Morton, Susan, Shelling, Andrew N., Sika-Paotonu, Dianne, Rolleston, Anna, Skinner, Jonathan R., Snell, Russell G., Sporle, Andrew, Print, Cristin, and Merriman, Tony R.

Published
2018

23. Mitochondrial genetic variation and gout in Māori and Pacific people living in Aotearoa New Zealand.

Author

Gosling, Anna L., Boocock, James, Dalbeth, Nicola, Hindmarsh, Jennie Harré, Stamp, Lisa K., Stahl, Eli A., Hyon K. Choi, Matisoo-Smith, Elizabeth A., Merriman, Tony R., Harré Hindmarsh, Jennie, and Choi, Hyon K

Abstract

Objective: Mitochondria have an important role in the induction of the NLRP3 inflammasome response central in gout. The objective was to test whether mitochondrial genetic variation and copy number in New Zealand Māori and Pacific (Polynesian) people in Aotearoa New Zealand associate with susceptibility to gout.Methods: 437 whole mitochondrial genomes from Māori and Pacific people (predominantly men) from Aotearoa New Zealand (327 people with gout, 110 without gout) were sequenced. Mitochondrial DNA copy number variation was determined by assessing relative read depth using data produced from whole genome sequencing (32 cases, 43 controls) and targeted resequencing of urate loci (151 cases, 222 controls). Quantitative PCR was undertaken for replication of copy number findings in an extended sample set of 1159 Māori and Pacific men and women (612 cases, 547 controls).Results: There was relatively little mitochondrial genetic diversity, with around 96% of those sequenced in this study belonging to the B4a1a and derived sublineages. A B haplogroup heteroplasmy in hypervariable region I was found to associate with a higher risk of gout among the mitochondrial sequenced sample set (position 16181: OR=1.57, P=0.001). Increased copies of mitochondrial DNA were found to protect against gout risk with the effect being consistent when using hyperuricaemic controls across each of the three independent sample sets (OR=0.89, P=0.007; OR=0.90, P=0.002; OR=0.76, P=0.03). Paradoxically, an increase of mitochondrial DNA also associated with an increase in gout flare frequency in people with gout in the two larger sample sets used for the copy number analysis (β=0.003, P=7.1×10-7; β=0.08, P=1.2×10-4).Conclusion: Association of reduced copy number with gout in hyperuricaemia was replicated over three Polynesian sample sets. Our data are consistent with emerging research showing that mitochondria are important for the colocalisation of the NLRP3 and ASC inflammasome subunits, a process essential for the generation of interleukin-1β in gout. [ABSTRACT FROM AUTHOR]

Published
2018
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