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3. Quantitative T1 brain mapping in early relapsing-remitting multiple sclerosis: longitudinal changes, lesion heterogeneity and disability.

Author

Harper, James G., York, Elizabeth N., Meijboom, Rozanna, Kampaite, Agniete, Thrippleton, Michael J., Kearns, Patrick K. A., Valdés Hernández, Maria del C., Chandran, Siddharthan, Waldman, Adam D., Akula, Amit, Baranzini, Sergio, Barret, Fiona, Bastin, Mark, Batchelor, Chris, Beswick, Emily, Brown, Fraser, Brunton, Tracy, Carod Artal, Javier, Chang, Jessie, and Chen, Yingdi

Subjects
*BRAIN mapping, *MULTIPLE sclerosis, *DISEASE relapse, *WHITE matter (Nerve tissue), *BASAL ganglia, *PEOPLE with disabilities
Abstract

Objectives: To quantify brain microstructural changes in recently diagnosed relapsing-remitting multiple sclerosis (RRMS) using longitudinal T1 measures, and determine their associations with clinical disability. Methods: Seventy-nine people with recently diagnosed (< 6 months) RRMS were recruited from a single-centre cohort sub-study, and underwent baseline and 1-year brain MRI, including variable flip angle T1 mapping. Median T1 was measured in white matter lesions (WML), normal-appearing white matter (NAWM), cortical/deep grey matter (GM), thalami, basal ganglia and medial temporal regions. Prolonged T1 (≥ 2.00 s) and supramedian T1 (relative to cohort WML values) WML voxel counts were also measured. Longitudinal change was assessed with paired t-tests and compared with Bland-Altman limits of agreement from healthy control test-retest data. Regression analyses determined relationships with Expanded Disability Status Scale (EDSS) score and dichotomised EDSS outcomes (worsening or stable/improving). Results: Sixty-two people with RRMS (mean age 37.2 ± 10.9 [standard deviation], 48 female) and 11 healthy controls (age 44 ± 11, 7 female) contributed data. Prolonged and supramedian T1 WML components increased longitudinally (176 and 463 voxels, respectively; p <.001), and were associated with EDSS score at baseline (p <.05) and follow-up (supramedian: p <.01; prolonged: p <.05). No cohort-wide median T1 changes were found; however, increasing T1 in WML, NAWM, cortical/deep GM, basal ganglia and thalami was positively associated with EDSS worsening (p <.05). Conclusion: T1 is sensitive to brain microstructure changes in early RRMS. Prolonged WML T1 components and subtle changes in NAWM and GM structures are associated with disability. Clinical relevance statement: MRI T1 brain mapping quantifies disability-associated white matter lesion heterogeneity and subtle microstructural damage in normal-appearing brain parenchyma in recently diagnosed RRMS, and shows promise for early objective disease characterisation and stratification. Key Points: • Quantitative T1 mapping detects brain microstructural damage and lesion heterogeneity in recently diagnosed relapsing-remitting multiple sclerosis. • T1 increases in lesions and normal-appearing parenchyma, indicating microstructural damage, are associated with worsening disability. • Brain T1 measures are objective markers of disability-relevant pathology in early multiple sclerosis. [ABSTRACT FROM AUTHOR]

Published
2024
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7. The Jesuits and the Arts (1540-1773)

Author

Harper, James G.

Subjects
The Jesuits and the Arts (1540-1773) (Book) -- O'Malley, John W. -- Bailey, Gauvin Alexander, Books -- Book reviews, Humanities, Literature/writing
Abstract

John W. O'Malley, S.J., and Gauvin Alexander Bailey, eds. The Jesuits and the Arts (1540-1773). Philadelphia: St. Joseph's University Press, 2005. xvi + 478 pp. index. illus. bibl. $50. ISBN: [...]

Published
2007

12. Propaganda and the Jesuit Baroque

Author

Harper, James G.

Subjects
Propaganda and the Jesuit Baroque (Book) -- Levy, Evonne, Books -- Book reviews, Humanities, Literature/writing
Abstract

Evonne Levy. Propaganda and the Jesuit Baroque. Berkeley and Los Angeles: The University of California Press, 2004. x + 354 pp. index. illus. bibl. $55. ISBN: 0-520-23357-3. The title of [...]

Published
2005

16. Tapestry in the Baroque: Threads of splendor: a symposium

Author

Campbell, Thomas P., Hubach, Hanns, De Meûter, Ingrid, Patrizi, Florence, Carretero, Concha Herrero, De Lavergnée, Arnauld Brejon, Bertrand, Pascal-François, 1956, Bremer-David, Charissa, Brosens, Koenraad, Delmarcel, Guy, Denis, Isabelle, Harper, James G., 1965, Hefford, Wendy, Meoni, Lucia, Bapasola, Jeri, Cleland, Elizabeth, Forti Grazzini, Nello, Hartkamp-Jonxis, Ebeltje, Herrero Carretero, Concha, Heyning, Katie, Knothe, Florian, Schmitz-von Ledebur, Katja, Smit, Hillie, 1956, Vittet, Jean, White, Bruce M, Metropolitan Museum of Art (New York, N.Y.), Campbell, Thomas P., Hubach, Hanns, De Meûter, Ingrid, Patrizi, Florence, Carretero, Concha Herrero, De Lavergnée, Arnauld Brejon, Bertrand, Pascal-François, 1956, Bremer-David, Charissa, Brosens, Koenraad, Delmarcel, Guy, Denis, Isabelle, Harper, James G., 1965, Hefford, Wendy, Meoni, Lucia, Bapasola, Jeri, Cleland, Elizabeth, Forti Grazzini, Nello, Hartkamp-Jonxis, Ebeltje, Herrero Carretero, Concha, Heyning, Katie, Knothe, Florian, Schmitz-von Ledebur, Katja, Smit, Hillie, 1956, Vittet, Jean, White, Bruce M, and Metropolitan Museum of Art (New York, N.Y.)

Abstract

Brochure for a symposium held Oct. 20 and Oct 21, 2007 at The Metropolitan Museum of Art. Drawing from collections in more than fifteen countries, Tapestry in the Baroque presents forty-five rare tapestries made between 1590 and 1720. About half of these derive from Flemish workshops, including such highlights of the Brussels tapestry industry as the Triumphs of the Church designed by Rubens for Archduchess Isabella in 1626 and tapestries from the Austrian state collection designed by Jacob Jordaens and others in the 1630s and 1640s. Flemish weavers also played key roles elsewhere in Europe, establishing new enterprises and training native weavers, and the publication also features rare examples from these new workshops.

Published
2007

20. Buckling Analysis of Laminated Composite Circular Cylindrical Shells.

Author

AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF ENGINEERING, Harper,James G , II, AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOOL OF ENGINEERING, and Harper,James G , II

Abstract

The effects of prebuckling displacements on the buckling 8 OF LAMINATED COMPOSITE CIRCULAR CYLINDRICAL SHELLS ARE INVESTIGATED. Both axial compression and pure torsion are considered for two shell geometries. A clamped prebuckling boundary condition is used for all analysis with four buckling boundary conditions applied during the buckling process. The shell walls are made up of a 6 ply laminate with several symmetric ply orientations. The study was made using the STAGS computer code, utilizing the linear bifurcation branch with linear prebuckling displacements. The results are compared to the buckling loads determined when prebuckling displacements are neglected. It is shown that prebuckling deformations generally tend to decrease the buckling load of a composite shell. Increased buckling loads can occur under axial compression with prebuckling displacements ASSUMED PRESENT, FOR PARTICULAR PLY ORIENTATIONS, DUE TO A HIGHER BENDING STIFFNESS. Similarly, under torsion, an increase in buckling load can occur because of a higher tension hoop stress. It is also shown that prebuckling displacements can cause shell buckling before failure of the fibers occurs. (Author)

Published
1978

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