26 results on '"Harold, Jaffe"'
Search Results
2. Differences in HIV natural history among African and non-African seroconverters in Europe and seroconverters in sub-Saharan Africa.
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Nikos Pantazis, Charles Morrison, Pauli N Amornkul, Charlotte Lewden, Robert A Salata, Albert Minga, Tsungai Chipato, Harold Jaffe, Shabir Lakhi, Etienne Karita, Kholoud Porter, Laurence Meyer, Giota Touloumi, and CASCADE Collaboration in EuroCoord and ANRS 1220 Primo-CI Study Group
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Medicine ,Science - Abstract
It is unknown whether HIV treatment guidelines, based on resource-rich country cohorts, are applicable to African populations.We estimated CD4 cell loss in ART-naïve, AIDS-free individuals using mixed models allowing for random intercept and slope, and time from seroconversion to clinical AIDS, death and antiretroviral therapy (ART) initiation by survival methods. Using CASCADE data from 20 European and 3 sub-Saharan African (SSA) cohorts of heterosexually-infected individuals, aged ≥15 years, infected ≥2000, we compared estimates between non-African Europeans, Africans in Europe, and Africans in SSA.Of 1,959 (913 non-Africans, 302 Europeans-African origin, 744 SSA), two-thirds were female; median age at seroconversion was 31 years. Individuals in SSA progressed faster to clinical AIDS but not to death or non-TB AIDS. They also initiated ART later than Europeans and at lower CD4 cell counts. In adjusted models, Africans (especially from Europe) had lower CD4 counts at seroconversion and slower CD4 decline than non-African Europeans. Median (95% CI) CD4 count at seroconversion for a 15-29 year old woman was 607 (588-627) (non-African European), 469 (442-497) (European-African origin) and 570 (551-589) (SSA) cells/µL with respective CD4 decline during the first 4 years of 259 (228-289), 155 (110-200), and 199 (174-224) cells/µL (p
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- 2012
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3. Associations between Burkitt lymphoma among children in Malawi and infection with HIV, EBV and malaria: results from a case-control study.
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Nora Mutalima, Elizabeth Molyneux, Harold Jaffe, Steve Kamiza, Eric Borgstein, Nyengo Mkandawire, George Liomba, Mkume Batumba, Dimitrios Lagos, Fiona Gratrix, Chris Boshoff, Delphine Casabonne, Lucy M Carpenter, and Robert Newton
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Medicine ,Science - Abstract
Burkitt lymphoma, a childhood cancer common in parts of sub-Saharan Africa, has been associated with Epstein Barr Virus (EBV) and malaria, but its association with human immunodeficiency virus (HIV) is not clear.We conducted a case-control study of Burkitt lymphoma among children (aged < or = 15 years) admitted to the pediatric oncology unit in Blantyre, Malawi between July 2005 and July 2006. Cases were 148 children diagnosed with Burkitt lymphoma and controls were 104 children admitted with non-malignant conditions or cancers other than hematological malignancies and Kaposi sarcoma. Interviews were conducted and serological samples tested for antibodies against HIV, EBV and malaria. Odds ratios for Burkitt lymphoma were estimated using unconditional logistic regression adjusting for sex, age, and residential district. Cases had a mean age of 7.1 years and 60% were male. Cases were more likely than controls to be HIV positive (Odds ratio (OR)) = 12.4, 95% Confidence Interval (CI) 1.3 to 116.2, p = 0.03). ORs for Burkitt lymphoma increased with increasing antibody titers against EBV (p = 0.001) and malaria (p = 0.01). Among HIV negative participants, cases were thirteen times more likely than controls to have raised levels of both EBV and malaria antibodies (OR = 13.2; 95% CI 3.8 to 46.6; p = 0.001). Reported use of mosquito nets was associated with a lower risk of Burkitt lymphoma (OR = 0.2, 95% CI, 0.03 to 0.9, p = 0.04).Our findings support prior evidence that EBV and malaria act jointly in the pathogenesis of Burkitt lymphoma, suggesting that malaria prevention may decrease the risk of Burkitt lymphoma. HIV may also play a role in the etiology of this childhood tumor.
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- 2008
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4. Picketing the Zeitgeist: XR
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Harold Jaffe
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media_common.quotation_subject ,General Medicine ,Art ,Religious studies ,Zeitgeist ,Picketing ,media_common - Published
- 2021
5. Transmission of Human Immunodeficiency Virus in a Dental Practice
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Ciesielski, Carol, Marianos, Donald, Ou, Chin-Yih, Dumbaugh, Robert, Witte, John, Berkelman, Ruth, Gooch, Barbara, Myers, Gerald, Luo, Chi-Ching, Schochetman, Gerald, Howell, James, Lasch, Alan, Bell, Kenneth, Economou, Nikki, Scott, Bob, Furman, Lawrence, Curran, James, and Harold, Jaffe
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- 1992
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6. Rates and determinants of virologic and immunological response to HAART resumption after treatment interruption in HIV-1 clinical practice
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Giota, Touloumi, Nikos, Pantazis, Heide A, Stirnadel, A Sarah, Walker, Faroudy, Boufassa, Philippe, Vanhems, Kholoud, Porter, Harold, Jaffe, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Amsterdam institute for Infection and Immunity, Amsterdam Public Health, Infectious diseases, and Epidemiology and Data Science
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Male ,Adult ,medicine.medical_specialty ,[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT] ,Adolescent ,Anti-HIV Agents ,Antiretroviral Therapy ,HIV Infections ,Drug Administration Schedule ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Acquired immunodeficiency syndrome (AIDS) ,Immunopathology ,Internal medicine ,Antiretroviral Therapy, Highly Active ,medicine ,Humans ,Pharmacology (medical) ,Highly Active ,030212 general & internal medicine ,Seroconversion ,Sida ,0303 health sciences ,biology ,030306 microbiology ,business.industry ,virus diseases ,Liter ,medicine.disease ,biology.organism_classification ,3. Good health ,CD4 Lymphocyte Count ,Regimen ,Infectious Diseases ,Immunology ,Lentivirus ,HIV-1 ,Female ,Viral disease ,sense organs ,business - Abstract
OBJECTIVE: To describe CD4 and HIV RNA changes during treatment resumption (TR) after treatment interruption (TI) compared with response to first highly active antiretroviral therapy (HAART) and to investigate predictors. METHODS: Using Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) data, we identified subjects who interrupted first HAART, not initiated during primary infection. We estimated rate of CD4 change during TR and time from TR to HIV RNA
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- 2016
7. Who's In? Who's Out?
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Pedro Ponce, Charles Marowitz, Janie Dade Smith, Jeff Bursey, Kevin Sampsell, Sheri Reda, Sascha Feinstein, Warren Woessner, Terry Caesar, Joseph D. Haske, Harold Jaffe, Geoffrey Gatza, Keith Taylor, W. Lawrence Hogue, Michael Lindgren, John Domini, David Kress, L. Timmel Duchamp, William Flesch, William O'Rourke, Alyson Leitch, Davis Schneiderman, Mark Amerika, Liedeke Plate, Robin Truth Goodman, Steven G. Kellman, Jonah Raskin, Christian Moraru, George Held, Jerry Harp, Alexis Pauline Gumbs, Lee Bellavance, and Lance Olsen
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General Medicine - Published
- 2011
8. Phylogenetic reconstruction of transmission events from individuals with acute HIV infection: toward more-rigorous epidemiological definitions
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Alison E, Brown, Robert J, Gifford, Jonathan P, Clewley, Claudia, Kucherer, Bernard, Masquelier, Kholoud, Porter, Claudia, Balotta, Nicole K T, Back, Louise Bruun, Jorgensen, Carmen, de Mendoza, Krishnan, Bhaskaran, O Noel, Gill, Anne M, Johnson, Deenan, Pillay, Harold, Jaffe, Medical Microbiology and Infection Prevention, Amsterdam institute for Infection and Immunity, Amsterdam Public Health, Infectious diseases, and Epidemiology and Data Science
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Acute HIV infection ,Infectivity ,Male ,medicine.medical_specialty ,Phylogenetic tree ,Transmission (medicine) ,Human immunodeficiency virus (HIV) ,Genetic Variation ,HIV Infections ,Biology ,medicine.disease_cause ,Virology ,Genes, pol ,Phylogenetic reconstruction ,Chronic infection ,Infectious Diseases ,Epidemiology ,Acute Disease ,medicine ,HIV-1 ,Immunology and Allergy ,Humans ,Female ,Phylogeny - Abstract
Phylogenetic reconstructions of transmission events from individuals with acute human immunodeficiency virus (HIV) infection are conducted to illustrate this group's heightened infectivity. Varied definitions of acute infection and assumptions about observed phylogenetic clusters may produce misleading results. We conducted a phylogenetic analysis of HIV pol sequences from 165 European patients with estimated infection dates and calculated the difference between dates within clusters. Nine phylogenetic clusters were observed. Comparison of dates within clusters revealed that only 2 could have been generated during acute infection. Previous analyses may have incorrectly assigned transmission events to the acutely HIV infected when they were more likely to have occurred during chronic infection.
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- 2009
9. Max Headroom
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Harold Jaffe
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- 2012
10. Decline of CD4⁺ T-cell count before start of therapy and immunological response to treatment in antiretroviral-naive individuals
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Cristina, Mussini, Andrea, Cossarizza, Caroline, Sabin, Abdel, Babiker, Andrea, De Luca, Heiner C, Bucher, Martin, Fisher, Giovanni, Rezza, Kholoud, Porter, Maria, Dorrucci, and Harold, Jaffe
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Male ,HAART ,HIV Infections ,030312 virology ,medicine.disease_cause ,0302 clinical medicine ,Interquartile range ,Immunology and Allergy ,Medicine ,030212 general & internal medicine ,0303 health sciences ,Middle Aged ,Viral Load ,HIV ,AIDS ,CD4 ,3. Good health ,Europe ,Infectious Diseases ,Anti-Retroviral Agents ,Practice Guidelines as Topic ,Cohort ,RNA, Viral ,Drug Therapy, Combination ,Female ,Viral load ,Adult ,Cart ,Canada ,medicine.medical_specialty ,Adolescent ,Hepatitis C virus ,Immunology ,Settore MED/17 - MALATTIE INFETTIVE ,Young Adult ,03 medical and health sciences ,Internal medicine ,Humans ,CD4 cell decline ,Seroconversion ,Aged ,business.industry ,Australia ,Confidence interval ,CD4 Lymphocyte Count ,HIV-1 ,Serostatus ,business - Abstract
OBJECTIVE Treatment guidelines recommend initiation of therapy for individuals experiencing rapid CD4 cell decline. It is not known, however, whether the rate of CD4 cell decline before combination antiretroviral therapy (cART) is related to immunological response following cART. METHODS We estimated precART and postcART CD4 cell slopes by mixed models and categorized patients into two groups according to whether estimated precART slopes were above or below the 75th percentile. We compared immunological responses of the two groups through both mixed models and survival techniques. Models were stratified by CD4 cell at baseline, adjusted for HIV RNA, age, sex, HIV transmission group, year of seroconversion, initiation during primary infection, hepatitis C virus and hepatitis B virus serostatus, and cART class. RESULTS Of 2038 eligible patients, 1531 and 507 experienced median (interquartile range) precART CD4 cell slope of −105 (−471 to −61) and −42 (−62 to −80) cells/μl, respectively, over 2 years. After adjusting for potential confounders, individuals with shallower decline experienced a slower rate of CD4 cell recovery following cART initiation of +9.5 [95% confidence interval (CI) +6.6 to +12.2] compared to +13.9 (+13.0 to +14.8) cells/μl per month among those with steeper precART decline (P < 0.001). After stratifying by the baseline CD4 cell count, the adjusted relative hazard of an increase from baseline of more than 50 cells/μl was 0.70 (95% CI 0.62−0.79) for those with a shallower vs. steeper precART decline. CONCLUSION Findings highlight the existence of a subgroup of individuals with shallower precART CD4 cell decline who experience poorer CD4 cell increases after cART; new studies in this group may provide information to optimize responses to therapy.
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- 2011
11. Letter to the Shade of Hemingway Regarding the Current State of Fiction
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Harold Jaffe
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Cultural Studies ,Literature ,History ,Literature and Literary Theory ,Aesthetics ,business.industry ,State (computer science) ,Current (fluid) ,business - Published
- 1992
12. Antibodies against malaria and Epstein-Barr virus in childhood Burkitt lymphoma: a case-control study in Uganda
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Lucy M, Carpenter, Robert, Newton, Delphine, Casabonne, John, Ziegler, Sam, Mbulaiteye, Edward, Mbidde, Henry, Wabinga, Harold, Jaffe, and Valerie, Beral
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Male ,Herpesvirus 4, Human ,Plasmodium falciparum ,Antibodies, Protozoan ,Antibodies, Viral ,Burkitt Lymphoma ,Case-Control Studies ,Child, Preschool ,Odds Ratio ,Animals ,Humans ,Female ,Uganda ,Malaria, Falciparum ,Child - Abstract
Burkitt lymphoma, a childhood tumor common in parts of sub-Saharan Africa, has been directly associated with Epstein-Barr virus (EBV) and indirectly with prevalence of malaria. We studied antibodies to both EBV and malaria in children diagnosed with this cancer in Uganda. We performed a case-control study of HIV-seronegative children (or=15 years) admitted to hospital. Cases were diagnosed with Burkitt lymphoma and controls with non-malignant conditions or non-lymphatic cancers. Interviews were conducted and serological samples collected and, when possible, tested for both EBV and malaria. Adjusted odds ratios (ORs) for Burkitt lymphoma were estimated using unconditional logistic regression adjusting for sex, age, residential district, household income and tribe. The mean age of cases was 7 years and 61% were male. Compared to controls, cases were more likely to be reported having received more frequent treatment for malaria in the past year (OR = 2.0; p = 0.001) and less likely to be living in a home where insecticides were used (OR = 0.2; p0.0001). Odds ratios for Burkitt lymphoma in children increased with increasing antibody levels against EBV (p0.0001) and malaria (p = 0.05). Findings were similar for children residing in districts close to the capital city and in remote areas. Cases were 5 times more likely than controls to have raised levels of both EBV and malaria antibodies (OR = 5.0; p = 0.003). Our findings suggest that EBV and malaria may act synergistically in the pathogenesis of childhood Burkitt lymphoma. Malaria prevention measures may also prevent this childhood cancer.
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- 2007
13. Infections and childhood cancer in Malawi
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Mutalima, Nora., Jaffe, Harold W., Carpenter, Lucy, Newton, R. (Robert), Prof. Harold Jaffe, and Dr. Lucy Carpenter
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Malawi ,Infection in children ,Etiology ,hemic and lymphatic diseases ,virus diseases ,Cancer in children ,Cancer - Abstract
The causes of childhood cancers are not well understood. That infections are believed to play an important role in childhood cancer development is of particular interest in sub-Saharan Africa, where infectious diseases are common. The objectives of this thesis were to identify childhood cancers associated with HIV, malaria, EBV and HHV-8, and to investigate child and maternal factors associated with Burkitt lymphoma and Kaposi sarcoma.In Blantyre, Malawi, 305 children diagnosed with cancer and 212 of their mothers, were recruited. Risk factor data were collected using a brief questionnaire and blood samples tested for infections.Case-control analyses were conducted to compare 148 Burkitt lymphoma cases and 22 Kaposi sarcoma case with a control group comprising 104 children with cancers other than those known to be associated with HIV.The prevalence of HIV was 6% among children with Burkitt lymphoma and 2% in controls (OR=12.4, 95% CI 1.3 to 116.2). Tumour risk increased with increasing litres of antibodies against EBV and malaria. In comparison with those who had low titres against both EBV and malaria, the highest risk of Burkitt lymphoma was among those with high titres against both infections (OR=13.2, 95% CI 3.8 to 46.6). Reported use of mosquito nets was protective against Burkitt lymphoma.The prevalence of HIV was 81% among children with Kaposi sarcoma (OR=762.7, 95% CI 44 to 13376), and risk increased with increasing HHV-8 antibodies. Prevalence of infections was also examined among children with other cancer types and no associations were identified, although the number of cases was small. Few maternal factors were found to be associated with cancer in children.This research demonstrates that infections play a particularly important role in increasing the risk of Burkitt lymphoma and Kaposi sarcoma in children in sub- Saharan Africa. Prevention or early treatment of these infections may be vital in the control of childhood cancer.
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- 2007
14. Public health. Whatever happened to the U.S. AIDS epidemic?
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Harold, Jaffe
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Male ,Acquired Immunodeficiency Syndrome ,Prisoners ,AIDS Serodiagnosis ,Public Policy ,United States ,Disease Outbreaks ,Black or African American ,Needle-Exchange Programs ,Humans ,Female ,Public Health ,Homosexuality, Male ,Substance Abuse, Intravenous ,Sexual Abstinence - Published
- 2004
15. Picketing the Zeitgeist: Crisis Art
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Harold Jaffe
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Political science ,Media studies ,General Medicine ,Zeitgeist ,Picketing - Published
- 2011
16. Guidelines for Preventing Opportunistic Infections among HIV-Infected Persons—2002: Recommendations of the U.S. Public Health Service and the Infectious Diseases Society of America*
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Julio Montaner, Cynthia L. Sears, Thomas C. Wright, David A. Cooper, John T. Brooks, Judith S. Currier, Mark J. Goldberger, Dennis D. Juranek, Harold Jaffe, Richard Hafner, Victoria A. Cargill, Joel Palefsky, Eric Mast, Peter Reiss, Mark S. Dworkin, Kent A. Sepkowitz, Steve Piscitelli, David R. Holtgrave, Thomas G. Slama, A. Cornelius Baker, Elaine M. Sloand, Wafaa El-Sadr, Peter A. Gross, Clare A. Dykewicz, William C. Reeves, Beverly Alston, Joseph F. O'Neill, Constance A. Benson, Timothy M. Uyeki, Rana Hajjeh, Leonard B. Seeff, Lynne M. Mofenson, D. Heather Watts, S D Holmberg, Kenneth G. Castro, Michael A. Polis, Richard E. Chaisson, John A. Stewart, Tedd Ellerbrock, Diane Havlir, M. Elsa Villarino, Clyde S. Crumpacker, Edward N. Janoff, Douglas A. Jabs, Jeffrey M. Jones, Keiji Fukuda, Kenneth A. Freedberg, Mark A. Jacobson, John W. Gnann, John G. Bartlett, Stephen A. Spector, Thomas Navin, Mari M. Kitahata, Anne Schuchat, L. Joseph Wheat, W. Lawrence Drew, Jose M. Gatell, William A. Bower, Hansjakob Furrer, Catherine Leport, Thomas C. Quinn, Phil Pellett, David A Barr, David Rimland, Joseph A. Kovacs, Judith Feinberg, Sue Goldie, King K. Holmes, Richard A. Moore, Thomas M. Hooton, Myron J. Levin, David L. Thomas, Jonathan E. Kaplan, Kenneth E. Sherman, Eric P. Goosby, Jean Anderson, Kevin M. DeCock, Robert W Eisinger, Charles Nelson, Jens D Lundgren, Samuel A. Bozzette, Scott F. Dowell, Douglas L. Mayers, John E. Bennett, Alice Pau, Paige L. Williams, Henry Masur, Fred M. Gordin, Juan C. Lopez, Michael Marco, Neil M. Ampel, William Duncan, Miriam J. Alter, Russell Van Dyke, John P. Phair, James D. Neaton, Lawrence Deyton, and Anna Wald
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Adult ,medicine.medical_specialty ,Gastrointestinal Diseases ,Opportunistic infection ,Sexually Transmitted Diseases ,Cryptosporidiosis ,Disease ,Herpes Zoster ,Chickenpox ,Acquired immunodeficiency syndrome (AIDS) ,Bartonella Infections ,Occupational Exposure ,Internal Medicine ,Animals ,Humans ,Tuberculosis ,Medicine ,Child ,Substance Abuse, Intravenous ,Intensive care medicine ,Respiratory Tract Infections ,Sarcoma, Kaposi ,Mycobacterium avium-intracellulare Infection ,Travel ,AIDS-Related Opportunistic Infections ,business.industry ,Transmission (medicine) ,Pneumonia, Pneumocystis ,Papillomavirus Infections ,Candidiasis ,Herpes Simplex ,Bacterial Infections ,Cryptococcosis ,Environmental Exposure ,General Medicine ,Guideline ,medicine.disease ,Hepatitis C ,Vaccination ,Food ,Animals, Domestic ,Toxoplasmosis, Cerebral ,Cytomegalovirus Infections ,Immunology ,Chemoprophylaxis ,Viral disease ,business - Abstract
In 1995, the U.S. Public Health Service (USPHS) and the Infectious Diseases Society of America (IDSA) developed guidelines for preventing opportunistic infections (OIs) among persons infected with human immunodeficiency virus (HIV); these guidelines were updated in 1997 and 1999. This fourth edition of the guidelines, made available on the Internet in 2001, is intended for clinicians and other health-care providers who care for HIV-infected persons. The goal of these guidelines is to provide evidence-based guidelines for preventing OIs among HIV-infected adults and adolescents, including pregnant women, and HIV-exposed or infected children. Nineteen OIs, or groups of OIs, are addressed, and recommendations are included for preventing exposure to opportunistic pathogens, preventing first episodes of disease by chemoprophylaxis or vaccination (primary prophylaxis), and preventing disease recurrence (secondary prophylaxis). Major changes since the last edition of the guidelines include 1) updated recommendations for discontinuing primary and secondary OI prophylaxis among persons whose CD4+ T lymphocyte counts have increased in response to antiretroviral therapy; 2) emphasis on screening all HIV-infected persons for infection with hepatitis C virus; 3) new information regarding transmission of human herpesvirus 8 infection; 4) new information regarding drug interactions, chiefly related to rifamycins and antiretroviral drugs; and 5) revised recommendations for immunizing HIV-infected adults and adolescents and HIV-exposed or infected children.
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- 2002
17. False Positive
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Stephen-Paul Martin and Harold Jaffe
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Literature and Literary Theory - Published
- 2002
18. Richard Maurice Bucke and Walt Whitman
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Harold Jaffe
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Cultural Studies ,History ,Literature and Literary Theory ,Art history ,Law and economics - Published
- 1971
19. Exact λ-numbers of generalized Petersen graphs of certain higher-orders and on Möbius strips
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Denise Sakai Troxell, Paul Booth, Sarah Spence Adams, Harold Jaffe, and S. Luke Zinnen
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Graph labeling ,L(2,1)-coloring ,Edge-graceful labeling ,0102 computer and information sciences ,Disjoint sets ,01 natural sciences ,Upper and lower bounds ,Combinatorics ,symbols.namesake ,Discrete Mathematics and Combinatorics ,Möbius strip ,Channel assignment ,0101 mathematics ,Mathematics ,Discrete mathematics ,L(2,1)-labeling ,Applied Mathematics ,010102 general mathematics ,Generalized Petersen graph ,Graph ,Vertex (geometry) ,010201 computation theory & mathematics ,symbols ,Distance two labeling - Abstract
An L(2,1)-labeling of a graph G is an assignment f of nonnegative integers to the vertices of G such that if vertices x and y are adjacent, |f(x)−f(y)|≥2, and if x and y are at distance two, |f(x)−f(y)|≥1. The λ-number of G is the minimum span over all L(2,1)-labelings of G. A generalized Petersen graph (GPG) of order n consists of two disjoint copies of cycles on n vertices together with a perfect matching between the two vertex sets. By presenting and applying a novel algorithm for identifying GPG-specific isomorphisms, this paper provides exact values for the λ-numbers of all GPGs of orders 9, 10, 11, and 12. For all but three GPGs of these orders, the λ-numbers are 5 or 6, improving the recently obtained upper bound of 7 for GPGs of orders 9, 10, 11, and 12. We also provide the λ-numbers of several infinite subclasses of GPGs that have useful representations on Möbius strips.
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20. Acquired immunodeficiency syndrome (AIDS) associated with transfusions
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James W. Curran, Dale N. Lawrence, Harold Jaffe, Jonathan E. Kaplan, Lawrence D. Zyla, Mary Chamberland, Robert Weinstein, Kung-Jong Lui, Lawrence B. Schonberger, Thomas J. Spira, W. James Alexander, Gary Swinger, Arthur Ammann, Steven Solomon, David Auerbach, Donna Mildvan, Rand Stoneburner, Janine M. Jason, Harry W. Haverkos, and Bruce L. Evatt
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Adult ,Male ,Risk ,Pediatrics ,medicine.medical_specialty ,Research methodology ,T-Lymphocytes ,Blood Donors ,Models, Biological ,Acquired immunodeficiency syndrome (AIDS) ,medicine ,Humans ,Aged ,Acquired Immunodeficiency Syndrome ,business.industry ,Pneumonia, Pneumocystis ,Transfusion Reaction ,General Medicine ,Middle Aged ,medicine.disease ,Disease control ,United States ,Pneumonia ,Pneumocystis carinii ,Immunology ,Female ,business ,Generalized lymphadenopathy ,Mathematics - Abstract
Of 2157 patients with the acquired immunodeficiency syndrome (AIDS) whose cases were reported to the Centers for Disease Control by August 22, 1983, 64 (3 per cent) with AIDS and Pneumocystis carinii pneumonia had no recognized risk factors for AIDS. Eighteen of these (28 per cent) had received blood components within five years before the onset of illness. These patients with transfusion-associated AIDS were more likely to be white (P = 0.00008) and older (P = 0.0013) than other patients with no known risk factors. They had received blood 15 to 57 months (median, 27.5) before the diagnosis of AIDS, from 2 to 48 donors (median, 14). At least one high-risk donor was identified by interview or T-cell-subset analysis in each of the seven cases in which investigation of the donors was complete; five of the six high-risk donors identified during interview also had low T-cell helper/suppressor ratios, and four had generalized lymphadenopathy according to history or examination. These findings strengthen the evidence that AIDS may be transmitted in blood.
- Published
- 1984
21. The Blood Donor
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Harold Jaffe
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Andrology ,Blood donor ,Literature and Literary Theory ,business.industry ,Medicine ,business - Published
- 1981
22. Madonna
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Harold Jaffe
- Published
- 1987
23. Man Ray
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Harold Jaffe
- Subjects
Cultural Studies ,History ,Literature and Literary Theory ,Sociology and Political Science - Published
- 1986
24. The Radical Readers
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Lois Michel, Victor Earl Amend, Leo Thomas Hendrick, Frederick Robert Karl, William Powers, John Tytell, Leo Hamalian, Muriel Blatt, Victor Comerchero, Joan G. Roloff, Leonard Wolf, Harold Jaffe, Douglas A. Hughes, Richard W. Lid, and Jean Wilkins
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Literature and Literary Theory ,Language and Linguistics ,Education - Published
- 1971
25. Short Story Anthologies
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Harold Jaffe, Paul J. Dolan, Leonard R. N. Ashley, Donald R. Zimbalist, Richard VanDerBeets, Paul Marx, Barbara McKenzie, James K. Bowen, Abe C. Ravitz, John Tytell, and William Wasserstrom
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Literature and Literary Theory ,Language and Linguistics ,Education - Published
- 1971
26. The CDC Clearance Process: Supporting Quality Science.
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Cono J and Jaffe H
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- Humans, Centers for Disease Control and Prevention, U.S. organization & administration, Editorial Policies, Information Dissemination, Peer Review, Research
- Published
- 2015
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- View/download PDF
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