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14 results on '"Harmsen, Iris"'

4. The Natural Course of Arterial Calcifications in Pseudoxanthoma Elasticum: A Prospective Cohort Study

Author

Researchgr. Systems Radiology, Interne Geneeskunde Vasculaire, Researchgr. Hart-brein as., MS Radiologie, Cancer, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, MS Interne Geneeskunde, van den Beukel, Tim C, Harmsen, Iris, Bos, Daniel, Mali, Willem P T, Kok, Madeleine, de Jong, Pim A, Spiering, Wilko, Researchgr. Systems Radiology, Interne Geneeskunde Vasculaire, Researchgr. Hart-brein as., MS Radiologie, Cancer, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, MS Interne Geneeskunde, van den Beukel, Tim C, Harmsen, Iris, Bos, Daniel, Mali, Willem P T, Kok, Madeleine, de Jong, Pim A, and Spiering, Wilko

Published
2024

5. Cyclical Etidronate Reduces the Progression of Arterial Calcifications in Patients with Pseudoxanthoma Elasticum: A 6-Year Prospective Observational Study

Author

Interne Geneeskunde Vasculaire, Researchgr. Systems Radiology, MS Radiologie, Circulatory Health, Cancer, Infection & Immunity, Regenerative Medicine and Stem Cells, MS Interne Geneeskunde, Harmsen, Iris M., van den Beukel, Tim, Kok, Madeleine, Visseren, Frank L.J., de Jong, Pim A., Papapoulos, Socrates E., Spiering, Wilko, Interne Geneeskunde Vasculaire, Researchgr. Systems Radiology, MS Radiologie, Circulatory Health, Cancer, Infection & Immunity, Regenerative Medicine and Stem Cells, MS Interne Geneeskunde, Harmsen, Iris M., van den Beukel, Tim, Kok, Madeleine, Visseren, Frank L.J., de Jong, Pim A., Papapoulos, Socrates E., and Spiering, Wilko

Published
2024

6. Plasma lipids in Pseudoxanthoma Elasticum (PXE) patients: A comparative study with population-based reference values and Non-PXE controls

Author

Interne Geneeskunde Vasculaire, Circulatory Health, MS Radiologie, Researchgr. Systems Radiology, Cancer, Infection & Immunity, Regenerative Medicine and Stem Cells, MS Interne Geneeskunde, Harmsen, Iris M, Visseren, Frank L J, Kok, Madeleine, de Jong, Pim A, Spiering, Wilko, Interne Geneeskunde Vasculaire, Circulatory Health, MS Radiologie, Researchgr. Systems Radiology, Cancer, Infection & Immunity, Regenerative Medicine and Stem Cells, MS Interne Geneeskunde, Harmsen, Iris M, Visseren, Frank L J, Kok, Madeleine, de Jong, Pim A, and Spiering, Wilko

Published
2024

7. Do pseudoxanthoma elasticum patients have higher prevalence of kidney stones on computed tomography compared to hospital controls?

Author

Interne Geneeskunde Vasculaire, MS Radiologie, Researchgr. Systems Radiology, Cancer, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, MS Interne Geneeskunde, Harmsen, Iris M., Kok, Madeleine, Bartstra, Jonas W., de Jong, Pim A., Spiering, Wilko, Foppen, Wouter, Interne Geneeskunde Vasculaire, MS Radiologie, Researchgr. Systems Radiology, Cancer, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, MS Interne Geneeskunde, Harmsen, Iris M., Kok, Madeleine, Bartstra, Jonas W., de Jong, Pim A., Spiering, Wilko, and Foppen, Wouter

Published
2024

8. Cyclical Etidronate Reduces the Progression of Arterial Calcifications in Patients with Pseudoxanthoma Elasticum: A 6-Year Prospective Observational Study.

Author

Harmsen, Iris M., van den Beukel, Tim, Kok, Madeleine, Visseren, Frank L. J., de Jong, Pim A., Papapoulos, Socrates E., and Spiering, Wilko

Subjects
*ARTERIAL calcification, *GENETIC disorders, *COMPUTED tomography, *CALCIFICATION, *GENETIC mutation
Abstract

Background: Pseudoxanthoma elasticum (PXE), a rare genetic disorder presenting with slowly progressing calcification of various tissues, including the arteries, is caused by mutations in the ABCC6 gene that lead to the reduction of pyrophosphate, a natural inhibitor of calcification. We showed that, compared to a placebo, the cyclical administration of etidronate, a stable pyrophosphate analog, significantly reduced arterial calcification assessed by low-dose CT scans after one year. The aim of the present prospective, single center, observational cohort study was the assessment of the efficacy and safety of cyclical etidronate in patients treated for periods longer than one year. Methods: Seventy-three patients were followed for a median of 3.6 years without etidronate and 2.8 years with etidronate, and each patient served as their own control. Results: The median absolute yearly progression of total calcification volume during the period with etidronate (388 [83–838] µL) was significantly lower than that without etidronate (761 [362–1415] µL; p < 0.001). The rates of the relative progression of arterial calcification were 11.7% (95% CI: 9.6–13.9) without etidronate compared to 5.3% (95% CI: 3.7–7.0) with etidronate, after adjustment for confounders. Conclusions: The cyclical administration of etidronate for nearly 3 years significantly reduced the progression rate of arterial calcification in patients with PXE with pre-existing calcifications without any serious adverse effects. [ABSTRACT FROM AUTHOR]

Published
2024
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12. High prevalence of breast arterial calcification in pseudoxanthoma elasticum (PXE) – A nationwide study in the Netherlands.

Author

Harmsen, Iris M, Kok, Madeleine, Visseren, Frank L, Spiering, Wilko, and de Jong, Pim A

Subjects
*ARTERIAL calcification, *CALCIFICATIONS of the breast, *METABOLIC disorders, *GLOMERULAR filtration rate, *BODY mass index
Abstract

The study published in Vascular Medicine explores the high prevalence of breast arterial calcification (BAC) in women over 50 with pseudoxanthoma elasticum (PXE) in the Netherlands. The research compares the prevalence of BAC in PXE patients to the general population, highlighting a stark contrast in prevalence rates. The study suggests that age, kidney function, and diabetes mellitus are risk factors for BAC in PXE, supporting the involvement of the tunica media in PXE-related arterial calcification. [Extracted from the article]

Published
2024
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13. The Association Between the Kyphosis Angle and Physical Performance in Community-Dwelling Older Adults

Author

Koelé, Marije C, primary, Willems, Hanna C, additional, Harmsen, Iris M, additional, Swart, Karin M A, additional, van Dijk, Suzanne C, additional, Lips, Paul, additional, de Groot, Lisette C P G M, additional, van der Cammen, Tischa J M, additional, Zillikens, M Carola, additional, van Schoor, Natasja M, additional, and van der Velde, Nathalie, additional

Published
2022
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14. The Association Between the Kyphosis Angle and Physical Performance in Community-Dwelling Older Adults

Author

Koelé, Marije C., Willems, Hanna C., Harmsen, Iris M., Swart, Karin M.A., van Dijk, Suzanne C., Lips, Paul, de Groot, Lisette C.P.G.M., van der Cammen, Tischa J.M., Zillikens, Carola, van Schoor, Natasja M., van der Velde, Nathalie, Koelé, Marije C., Willems, Hanna C., Harmsen, Iris M., Swart, Karin M.A., van Dijk, Suzanne C., Lips, Paul, de Groot, Lisette C.P.G.M., van der Cammen, Tischa J.M., Zillikens, Carola, van Schoor, Natasja M., and van der Velde, Nathalie

Abstract

BACKGROUND: We investigated prospectively among community-dwelling older adults aged 65 years and older whether a larger kyphosis angle is associated with poorer physical performance (balance, muscle strength, or both), and whether this association is unidirectional. METHODS: Male and female participants performed a multicomponent physical performance test with subscores for gait, muscle strength, and balance at baseline and after 2 years. Hand grip strength was also measured at baseline and at follow-up. The Cobb angle was measured on DXA-based Vertebral Fracture Assessments, made at the baseline and follow-up visit. Through linear and logistic regression analysis, we investigated the association between the kyphosis angle and physical performance and vice versa. We stratified for sex, and tested for effect modification by age and study center. RESULTS: The mean kyphosis angle was 37° and 15% of the participants (n = 1 220, mean age 72.9 ± 5.7 years) had hyperkyphosis (Cobb angle ≥50°). A larger kyphosis angle at baseline was independently associated with a poorer total physical performance score in women of the oldest quartile (≥77 years) in both the cross-sectional and longitudinal analyses (baseline B -0.32, 95% confidence interval [CI] -0.56-0.08; follow-up B 0.32, 95% CI -0.55-0.10). There was no association between physical performance at baseline and kyphosis progression. CONCLUSION: A larger kyphosis angle is independently associated with a poorer physical performance at baseline and over time, and the direction of this association is unidirectional. These results emphasize the importance of early detection and treatment of hyperkyphosis to prevent further worsening of the kyphosis angle, thereby potentially preserving physical performance.

Published
2022

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