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1. AGATA - Advanced Gamma Tracking Array

Author

Akkoyun, S., Algora, A., Alikhani, B., Ameil, F., de Angelis, G., Arnold, L., Astier, A., Ataç, A., Aubert, Y., Aufranc, C., Austin, A., Aydin, S., Azaiez, F., Badoer, S., Balabanski, D. L., Barrientos, D., Baulieu, G., Baumann, R., Bazzacco, D., Beck, F. A., Beck, T., Bednarczyk, P., Bellato, M., Bentley, M. A., Benzoni, G., Berthier, R., Berti, L., Beunard, R., Bianco, G. Lo, Birkenbach, B., Bizzeti, P. G., Bizzeti-Sona, A. M., Blanc, F. Le, Blasco, J. M., Blasi, N., Bloor, D., Boiano, C., Borsato, M., Bortolato, D., Boston, A. J., Boston, H. C., Bourgault, P., Boutachkov, P., Bouty, A., Bracco, A., Brambilla, S., Brawn, I. P., Brondi, A., Broussard, S., Bruyneel, B., Bucurescu, D., Burrows, I., Bürger, A., Cabaret, S., Cahan, B., Calore, E., Camera, F., Capsoni, A., Carrió, F., Casati, G., Castoldi, M., Cederwall, B., Cercus, J. -L., Chambert, V., Chambit, M. El, Chapman, R., Charles, L., Chavas, J., Clément, E., Cocconi, P., Coelli, S., Coleman-Smith, P. J., Colombo, A., Colosimo, S., Commeaux, C., Conventi, D., Cooper, R. J., Corsi, A., Cortesi, A., Costa, L., Crespi, F. C. L., Cresswell, J. R., Cullen, D. M., Curien, D., Czermak, A., Delbourg, D., Depalo, R., Descombes, T., Désesquelles, P., Detistov, P., Diarra, C., Didierjean, F., Dimmock, M. R., Doan, Q. T., Domingo-Pardo, C., Doncel, M., Dorangeville, F., Dosme, N., Drouen, Y., Duchêne, G., Dulny, B., Eberth, J., Edelbruck, P., Egea, J., Engert, T., Erduran, M. N., Ertürk, S., Fanin, C., Fantinel, S., Farnea, E., Faul, T., Filliger, M., Filmer, F., Finck, Ch., de France, G., Gadea, A., Gast, W., Geraci, A., Gerl, J., Gernhäuser, R., Giannatiempo, A., Giaz, A., Gibelin, L., Givechev, A., Goel, N., González, V., Gottardo, A., Grave, X., Grȩbosz, J., Griffiths, R., Grint, A. N., Gros, P., Guevara, L., Gulmini, M., Görgen, A., Ha, H. T. M., Habermann, T., Harkness, L. J., Harroch, H., Hauschild, K., He, C., Hernández-Prieto, A., Hervieu, B., Hess, H., Hüyük, T., Ince, E., Isocrate, R., Jaworski, G., Johnson, A., Jolie, J., Jones, P., Jonson, B., Joshi, P., Judson, D. S., Jungclaus, A., Kaci, M., Karkour, N., Karolak, M., Kaşkaş, A., Kebbiri, M., Kempley, R. S., Khaplanov, A., Klupp, S., Kogimtzis, M., Kojouharov, I., Korichi, A., Korten, W., Kröll, Th., Krücken, R., Kurz, N., Ky, B. Y., Labiche, M., Lafay, X., Lavergne, L., Lazarus, I. H., Leboutelier, S., Lefebvre, F., Legay, E., Legeard, L., Lelli, F., Lenzi, S. M., Leoni, S., Lermitage, A., Lersch, D., Leske, J., Letts, S. C., Lhenoret, S., Lieder, R. M., Linget, D., Ljungvall, J., Lopez-Martens, A., Lotodé, A., Lunardi, S., Maj, A., van der Marel, J., Mariette, Y., Marginean, N., Marginean, R., Maron, G., Mather, A. R., Mȩczyński, W., Mendéz, V., Medina, P., Melon, B., Menegazzo, R., Mengoni, D., Merchan, E., Mihailescu, L., Michelagnoli, C., Mierzejewski, J., Milechina, L., Million, B., Mitev, K., Molini, P., Montanari, D., Moon, S., Morbiducci, F., Moro, R., Morrall, P. S., Möller, O., Nannini, A., Napoli, D. R., Nelson, L., Nespolo, M., Ngo, V. L., Nicoletto, M., Nicolini, R., Noa, Y. Le, Nolan, P. J., Norman, M., Nyberg, J., Obertelli, A., Olariu, A., Orlandi, R., Oxley, D. C., Özben, C., Ozille, M., Oziol, C., Pachoud, E., Palacz, M., Palin, J., Pancin, J., Parisel, C., Pariset, P., Pascovici, G., Peghin, R., Pellegri, L., Perego, A., Perrier, S., Petcu, M., Petkov, P., Petrache, C., Pierre, E., Pietralla, N., Pietri, S., Pignanelli, M., Piqueras, I., Podolyak, Z., Pouhalec, P. Le, Pouthas, J., Pugnére, D., Pucknell, V. F. E., Pullia, A., Quintana, B., Raine, R., Rainovski, G., Ramina, L., Rampazzo, G., La Rana, G., Rebeschini, M., Recchia, F., Redon, N., Reese, M., Reiter, P., Regan, P. H., Riboldi, S., Richer, M., Rigato, M., Rigby, S., Ripamonti, G., Robinson, A. P., Robin, J., Roccaz, J., Ropert, J. -A., Rossé, B., Alvarez, C. Rossi, Rosso, D., Rubio, B., Rudolph, D., Saillant, F., Şahin, E., Salomon, F., Salsac, M. -D., Salt, J., Salvato, G., Sampson, J., Sanchis, E., Santos, C., Schaffner, H., Schlarb, M., Scraggs, D. P., Seddon, D., Şenyiğit, M., Sigward, M. -H., Simpson, G., Simpson, J., Slee, M., Smith, J. F., Sona, P., Sowicki, B., Spolaore, P., Stahl, C., Stanios, T., Stefanova, E., Stézowski, O., Strachan, J., Suliman, G., Söderström, P. -A., Tain, J. L., Tanguy, S., Tashenov, S., Theisen, Ch., Thornhill, J., Tomasi, F., Toniolo, N., Touzery, R., Travers, B., Triossi, A., Tripon, M., Tun-Lanoë, K. M. M., Turcato, M., Unsworth, C., Ur, C. A., Valiente-Dobon, J. J., Vandone, V., Vardaci, E., Venturelli, R., Veronese, F., Veyssiere, Ch., Viscione, E., Wadsworth, R., Walker, P. M., Warr, N., Weber, C., Weisshaar, D., Wells, D., Wieland, O., Wiens, A., Wittwer, G., Wollersheim, H. J., Zocca, F., Zamfir, N. V., Ziȩbliński, M., and Zucchiatti, A.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

The Advanced GAmma Tracking Array (AGATA) is a European project to develop and operate the next generation gamma-ray spectrometer. AGATA is based on the technique of gamma-ray energy tracking in electrically segmented high-purity germanium crystals. This technique requires the accurate determination of the energy, time and position of every interaction as a gamma ray deposits its energy within the detector volume. Reconstruction of the full interaction path results in a detector with very high efficiency and excellent spectral response. The realization of gamma-ray tracking and AGATA is a result of many technical advances. These include the development of encapsulated highly-segmented germanium detectors assembled in a triple cluster detector cryostat, an electronics system with fast digital sampling and a data acquisition system to process the data at a high rate. The full characterization of the crystals was measured and compared with detector-response simulations. This enabled pulse-shape analysis algorithms, to extract energy, time and position, to be employed. In addition, tracking algorithms for event reconstruction were developed. The first phase of AGATA is now complete and operational in its first physics campaign. In the future AGATA will be moved between laboratories in Europe and operated in a series of campaigns to take advantage of the different beams and facilities available to maximize its science output. The paper reviews all the achievements made in the AGATA project including all the necessary infrastructure to operate and support the spectrometer., Comment: This version contains a correction of a typing error in the caption of Fig. 2. The DOI to the article published in Nucl. Instr. Meth A was also added

Published
2011
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3. Spectroscopic quadrupole moments in 124Xe

Author

Clement, E., Lemasson, A., Rejmund, M., Jacquot, B., Ralet, D., Michelagnoli, C., Barrientos, D., Bednarczyk, P., Benzoni, G., Boston, A. J., Bracco, A., Cederwall, B., Ciemala, M., Collado, J., Crespi, F., Domingo-Pardo, C., Dudouet, J., Eberth, H. J., de France, G., Gadea, A., Gonzalez, V., Gottardo, A., Harkness, L., Hess, H., Jungclaus, A., Kaskas, A., Korten, W., Lenzi, S. M., Leoni, S., Ljungvall, J., Menegazzo, R., Mengoni, D., Million, B., Napoli, D. R., Nyberg, Johan, Podolyak, Zs., Pullia, A., Arnes, B. Quintana, Recchia, F., Redon, N., Reiter, P., Salsac, M. D., Sanchis, E., Senyigit, M., Siciliano, M., Sohler, D., Stezowski, O., Theisen, C., Dobon, J. J. Valiente, Clement, E., Lemasson, A., Rejmund, M., Jacquot, B., Ralet, D., Michelagnoli, C., Barrientos, D., Bednarczyk, P., Benzoni, G., Boston, A. J., Bracco, A., Cederwall, B., Ciemala, M., Collado, J., Crespi, F., Domingo-Pardo, C., Dudouet, J., Eberth, H. J., de France, G., Gadea, A., Gonzalez, V., Gottardo, A., Harkness, L., Hess, H., Jungclaus, A., Kaskas, A., Korten, W., Lenzi, S. M., Leoni, S., Ljungvall, J., Menegazzo, R., Mengoni, D., Million, B., Napoli, D. R., Nyberg, Johan, Podolyak, Zs., Pullia, A., Arnes, B. Quintana, Recchia, F., Redon, N., Reiter, P., Salsac, M. D., Sanchis, E., Senyigit, M., Siciliano, M., Sohler, D., Stezowski, O., Theisen, C., and Dobon, J. J. Valiente

Abstract

Background: The Xe isotopic chain with four valence protons above the Z = 50 shell closure is an ideal laboratory for the study of the evolution of nuclear deformation. At the N = 82 shell closure, 136Xe presents all characteristics of a doubly closed shell nucleus with a spherical shape. In the very neutron-deficient isotopes close to N = 50, the alpha-decay chain of Xe was investigated to probe the radioactive decay properties near the drip-line and the magicity of 100Sn. Additionally, the Xe isotopes present higher order symmetries in the nuclear deformation such as the octupole degree of freedom near N = 60 and N = 90 or O(6) symmetry in stable isotopes. Purpose: The relevance of the O(6) symmetry has been investigated by measuring the spectroscopic quadrupole moment of the first excited states in 124Xe. In the O(6) symmetry limit, the spectroscopic quadrupole moment of collective states is expected to be null. Method: A stable 124Xe beam with energies of 4.03A MeV and 4.11A MeV was used to bombard a natW target at the GANIL facility. Excited states were populated via the safe Coulomb excitation reaction. The collision of the heavy ions with a large Z at low energy make this reaction sensitive to the diagonal E2 matrix element of the excited states. The recoils were detected in the VAMOS++ magnetic spectrometer and the gamma rays in the AGATA tracking array. The least squares fitting code GOSIA was used for the analysis to extract both E2 and M1 transitional and E2 diagonal matrix elements. Results: The rotational ground state band was populated up to the 8+1 state as well as the 2+2 and 4+2 states. Using high precision spectroscopic data to constrain the GOSIA fit, the spectroscopic quadrupole moments of the 2+1 , 4+1 , and 6+1 states were determined for the first time. Conclusions: The spectroscopic quadrupole moments were found to be negative, large, and constant in the ground state band underlining the prolate axially deformed ground state band of 124Xe. The

Published
2023
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4. Spectroscopic quadrupole moments in Xe124

Author

Clément, E., primary, Lemasson, A., additional, Rejmund, M., additional, Jacquot, B., additional, Ralet, D., additional, Michelagnoli, C., additional, Barrientos, D., additional, Bednarczyk, P., additional, Benzoni, G., additional, Boston, A. J., additional, Bracco, A., additional, Cederwall, B., additional, Ciemala, M., additional, Collado, J., additional, Crespi, F., additional, Domingo-Pardo, C., additional, Dudouet, J., additional, Eberth, H. J., additional, de France, G., additional, Gadea, A., additional, Gonzalez, V., additional, Gottardo, A., additional, Harkness, L., additional, Hess, H., additional, Jungclaus, A., additional, Kaşkaş, A., additional, Korten, W., additional, Lenzi, S. M., additional, Leoni, S., additional, Ljungvall, J., additional, Menegazzo, R., additional, Mengoni, D., additional, Million, B., additional, Napoli, D. R., additional, Nyberg, J., additional, Podolyak, Zs., additional, Pullia, A., additional, Quintana Arnés, B., additional, Recchia, F., additional, Redon, N., additional, Reiter, P., additional, D.Salsac, M., additional, Sanchis, E., additional, Şenyiğit, M., additional, Siciliano, M., additional, Sohler, D., additional, Stezowski, O., additional, Theisen, C., additional, and Valiente Dobón, J. J., additional

Published
2023
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10. Coulomb excitation of radioactive 20, 21Na

Author

Schumaker, M. A., Cline, D., Hackman, G., Pearson, C., Svensson, C. E., Wu, C. Y., Andreyev, A., Austin, R. A. E., Ball, G. C., Bandyopadhyay, D., Becker, J. A., Boston, A. J., Boston, H. C., Buchmann, L., Churchman, R., Cifarelli, F., Cooper, R. J., Cross, D. S., Dashdorj, D., Demand, G. A., Dimmock, M. R., Drake, T. E., Finlay, P., Gallant, A. T., Garrett, P. E., Green, K. L., Grint, A. N., Grinyer, G. F., Harkness, L. J., Hayes, A. B., Kanungo, R., Lisetskiy, A. F., Leach, K. G., Lee, G., Maharaj, R., Martin, J-P., Moisan, F., Morton, A. C., Mythili, S., Nelson, L., Newman, O., Nolan, P. J., Orce, J. N., Padilla-Rodal, E., Phillips, A. A., Porter-Peden, M., Ressler, J. J., Roy, R., Ruiz, C., Sarazin, F., Scraggs, D. P., Waddington, J. C., Wan, J. M., Whitbeck, A., Williams, S. J., and Wong, J.

Published
2009
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13. Evidence of octupole-phonons at high spin in Pb

Author

Ralet, D., Clément, E., Georgiev, G., Stuchbery, A.E., Rejmund, M., Van Isacker, P., de France, G., Lemasson, A., Ljungvall, J., Michelagnoli, C., Navin, A., Balabanski, D.L., Atanasova, L., Blazhev, A., Bocchi, G., Carroll, R., Dudouet, J., Dupont, E., Fornal, B., Franchoo, S., Fransen, C., Müller-Gatermann, C., Goasduff, A., Gadea, A., John, P.R., Kocheva, D., Konstantinopoulos, T., Korichi, A., Kusoglu, A., Lenzi, S.M., Leoni, S., Lozeva, R., Maj, A., Perez, R., Pietralla, N., Shand, C., Stezowski, O., Wilmsen, D., Yordanov, D., Barrientos, D., Bednarczyk, P., Birkenbach, B., Boston, A.J., Boston, H.C., Burrows, I., Cederwall, B., Ciemala, M., Collado, J., Crespi, F., Cullen, D., Eberth, H.J., Goupil, J., Harkness, L., Hess, H., Jungclaus, A., Korten, W., Labiche, M., Menegazzo, R., Mengoni, D., Million, B., Nyberg, J., Podolyák, Zs., Pullia, A., Quintana Arnés, B., Recchia, F., Reiter, P., Saillant, F., Salsac, M.D., Sanchis, E., Theisen, C., Valiente Dobon, J.J., and Wieland, O.

Abstract

A lifetime measurement of the 19/2− state in $^{207}$Pb has been performed using the Recoil Distance Doppler-Shift (RDDS) method. The nuclei of interest were produced in multi-nucleon transfer reactions induced by a $^{208}$Pb beam impinging on a $^{100}$Mo enriched target. The beam-like nuclei were detected and identified in terms of their atomic mass number in the VAMOS++ spectrometer while the prompt γ rays were detected by the AGATA tracking array. The measured large reduced transition probability B(E3,19/2−→13/2+)=40(8) W.u. is the first indication of the octupole phonon at high spin in $^{207}$Pb. An analysis in terms of a particle-octupole-vibration coupling model indicates that the measured B(E3) value in $^{207}$Pb is compatible with the contributions from single-phonon and single particle E3 as well as E3 strength arising from the double-octupole-phonon 6+ state, all adding coherently. A crucial aspect of the coupling model, namely the strong mixing between single-hole and the phonon-hole states, is confirmed in a realistic shell-model calculation.

Published
2019

14. Evidence of octupole-phonons at high spin in Pb-207

Author

Ralet, D., Clement, E., Georgiev, G., Stuchbery, A. E., Rejmund, M., Van Isacker, R., de France, G., Lemasson, A., Ljungvall, J., Michelagnoli, C., Navin, A., Balabanski, D. L., Atanasova, L., Blazhev, A., Bocchi, G., Carroll, R., Dudouet, J., Dupont, E., Forna, B., Franchoo, S., Fransen, C., Mueller-Gatermann, C., Goasduff, A., Gadea, A., John, P. R., Kocheva, D., Konstantinopoulos, T., Korichi, A., Kusoglu, A., Lenzi, S. M., Leoni, S., Lozeva, R., Maj, A., Perez, R., Pietralla, N., Shand, C., Stezowski, O., Wilmsen, D., Yordanov, D., Barrientos, D., Bednarczyk, R., Birkenbach, B., Boston, A. J., Boston, H. C., Burrows, I, Cederwall, B., Ciemala, M., Collado, J., Crespi, F., Cullen, D., Eberth, H. J., Goupil, J., Harkness, L., Hess, H., Jungclaus, A., Korten, W., Labiche, M., Menegazzo, R., Mengoni, D., Million, B., Nyberg, Johan, Podolyak, Zs, Pullia, A., Quintana Arnes, B., Recchia, F., Reiter, R., Saillant, F., Salsac, M. D., Sanchis, E., Theisen, C., Dobon, J. J. Valiente, and Wieland, O.

Subjects
Subatomär fysik, Plunger device, VAMOS plus plus spectrometer, Subatomic Physics, Octupole phonon, AGATA spectrometer, gamma-Ray tracking, Nuclear deformation
Abstract

A lifetime measurement of the 19/2(-) state in Pb-207 has been performed using the Recoil Distance Doppler-Shift (RDDS) method. The nuclei of interest were produced in multi-nucleon transfer reactions induced by a Pb-208 beam impinging on a Mo-100 enriched target. The beam-like nuclei were detected and identified in terms of their atomic mass number in the VAMOS++ spectrometer while the prompt gamma rays were detected by the AGATA tracking array. The measured large reduced transition probability B(E3, 19/2(-) -> 13/2(+)) = 40(8) W.u. is the first indication of the octupole phonon at high spin in Pb-207. An analysis in terms of a particle-octupole-vibration coupling model indicates that the measured B(E3) value in Pb-207 is compatible with the contributions from single-phonon and single particle E3 as well as E3 strength arising from the double-octupole-phonon 6(+) state, all adding coherently. A crucial aspect of the coupling model, namely the strong mixing between single-hole and the phonon-hole states, is confirmed in a realistic shell-model calculation. Crown Copyright (C) 2019 Published by Elsevier B.V.

Published
2019

15. Evidence of octupole-phonons at high spin in 207Pb

Author

Ralet, D., primary, Clément, E., additional, Georgiev, G., additional, Stuchbery, A.E., additional, Rejmund, M., additional, Van Isacker, P., additional, de France, G., additional, Lemasson, A., additional, Ljungvall, J., additional, Michelagnoli, C., additional, Navin, A., additional, Balabanski, D.L., additional, Atanasova, L., additional, Blazhev, A., additional, Bocchi, G., additional, Carroll, R., additional, Dudouet, J., additional, Dupont, E., additional, Fornal, B., additional, Franchoo, S., additional, Fransen, C., additional, Müller-Gatermann, C., additional, Goasduff, A., additional, Gadea, A., additional, John, P.R., additional, Kocheva, D., additional, Konstantinopoulos, T., additional, Korichi, A., additional, Kusoglu, A., additional, Lenzi, S.M., additional, Leoni, S., additional, Lozeva, R., additional, Maj, A., additional, Perez, R., additional, Pietralla, N., additional, Shand, C., additional, Stezowski, O., additional, Wilmsen, D., additional, Yordanov, D., additional, Barrientos, D., additional, Bednarczyk, P., additional, Birkenbach, B., additional, Boston, A.J., additional, Boston, H.C., additional, Burrows, I., additional, Cederwall, B., additional, Ciemala, M., additional, Collado, J., additional, Crespi, F., additional, Cullen, D., additional, Eberth, H.J., additional, Goupil, J., additional, Harkness, L., additional, Hess, H., additional, Jungclaus, A., additional, Korten, W., additional, Labiche, M., additional, Menegazzo, R., additional, Mengoni, D., additional, Million, B., additional, Nyberg, J., additional, Podolyák, Zs., additional, Pullia, A., additional, Quintana Arnés, B., additional, Recchia, F., additional, Reiter, P., additional, Saillant, F., additional, Salsac, M.D., additional, Sanchis, E., additional, Theisen, C., additional, Valiente Dobon, J.J., additional, and Wieland, O., additional

Published
2019
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19. Induction of quiescence (GO) in bone marrow stromal stem cells enhances their stem cell characteristics

Author

RUMMAN, M, MAJUMDER, A, HARKNESS, L, VENUGOPAL, B, VINAY, MB, PILLAI, MS, KASSEM, M, and DHAWAN, J

Subjects
Suspension culture, EXPRESSION, GROWTH-FACTOR, ANCHORAGE-DEPENDENT FIBROBLASTS, Reprogramming, Cell cycle, CXC CHEMOKINE, SUBSTRATE STIFFNESS, GENE, CYCLIN-A, MYOCARDIAL-INFARCTION, BMSC, SATELLITE CELLS, Adhesion, CONTACT INHIBITION, Osteoblastic differentiation, Transcriptome, Quiescence (GO)
Abstract

Several studies have suggested that bone marrow stromal steam cells (BMSC) exist in a quiescent state (GO) within the in vivo niche; however, an explicit analysis of the biology of GO state-BMSC has not been reported. We hypothesized that induction of GO in BMSC might enhance their stem cell properties. Thus, we induced quiescence in BMSC in vitro by (a) suspension culture in a viscous medium or (b) culture on soft polyacrylamide substrate; and examined their molecular and functional phenotype. Induction of GO was confirmed by bromodeoxyuridine (BrdU) labelling and analysis of cell cycle gene expression. Upon reactivation and re-entry into cell cycle, GO state-BMSC exhibited enhanced clonogenic self-renewal, preferential differentiation into osteoblastic rather than adipocytic cells and increased ectopic bone formation when implanted subcutaneously in vivo in immune-deficient mice, compared to asynchronous proliferating (pre-GO) BMSC. Global gene expression profiling revealed reprogramming of the transcriptome during GO state including significant alterations in relevant pathways and expression of secreted factors, suggesting altered autocrine and paracrine signaling by GO state-BMSC and a possible mechanism for enhanced bone formation. GO state-BMSC might provide a clinically relevant model for understanding the in vivo biology of BMSC.

Published
2018

20. The ECM deposited by basal asthmatic and non-asthmatic ASM cells is different in composition but not biological function

Author

Harkness, L., Ashton, A., Burgess, J., Groningen Research Institute for Asthma and COPD (GRIAC), and Restoring Organ Function by Means of Regenerative Medicine (REGENERATE)

Subjects
collagen, extracellular matrix, respiratory tract inflammation, Australia and New Zealand, Student t test, angiogenesis, cell lysate, airway remodeling, vascularization, fibronectin, tumor microenvironment, cell growth, biological functions, human, umbilical vein endothelial cell, Australian, asthma, assay, microenvironment, enzyme linked immunosorbent assay, society, cell proliferation, airway, smooth muscle fiber, cell function, protein, New Zealand
Abstract

Aim: The remodelled asthmatic airway has increased airway smooth muscle cell (ASMC) growth, expanded vasculature, and altered extracellular matrix (ECM). The ECM is the external cellular microenvironment which regulates cell behaviour. Under proliferative, inflammatory, or fibrotic conditions, the asthmaticASM cells (AASMCs) deposit altered patterns of ECM proteins. However, it is unclear whether this is the case under basal, unstimulated conditions. This study aims to examine the composition of the ECM deposited by unstimulated NA (nonasthmatic)- and AASMCs, and biological potential for modulating blood vessel formation. Methods: Primary ASMCs from asthmatic and non-asthmatic individuals were quiesced in 0.1% BSA media after 72 hr of growth. After 24 hr ASMCs were lysed and the ECM either collected in lysate buffer and quantified using BCA, or kept intact and examined for collagen and fibronectin using Picrosirius Red and ELISA, respectively. Angiogenic potential was determined by examining Human Umbilical Vein Endothelial Cell (HUVEC) proliferation on (MTT and Cyquant assays), and attachment to ASMC-derived ECM. Unpaired t-tests were utilised to identify differences between NAASMC and AASMC-derived ECM. Results: Although the total amount of ECM deposited did not change (AASM N = 4 and NAASM N = 3 respectively), AASMCs deposited more collagen (N = 5, P

Published
2015

22. Transcription factor ZNF25 is associated with osteoblast differentiation of human skeletal stem cells

Author

Twine, NA, Harkness, L, Kassem, M, Wilkins, MR, Twine, NA, Harkness, L, Kassem, M, and Wilkins, MR

Abstract

© 2016 The Author(s). Background: The differentiation of human bone marrow derived skeletal stem cells (known as human bone marrow stromal or mesenchymal stem cells, hMSCs) into osteoblasts involves the activation of a small number of well-described transcription factors. To identify additional osteoblastic transcription factors, we studied gene expression of hMSCs during ex vivo osteoblast differentiation. Results: Clustering of gene expression, and literature investigation, revealed three transcription factors of interest - ZNF25, ZNF608 and ZBTB38. siRNA knockdown of ZNF25 resulted in significant suppression of alkaline phosphatase (ALP) activity. This effect was not present for ZNF608 and ZBTB38. To identify possible target genes of ZNF25, we analyzed gene expression following ZNF25 siRNA knockdown. This revealed a 23-fold upregulation of matrix metallopeptidase 1 and an 18-fold upregulation of leucine-rich repeat containing G protein-coupled receptor 5 and RAN-binding protein 3-like. We also observed enrichment in extracellular matrix organization, skeletal system development and regulation of ossification in the entire upregulated set of genes. Consistent with its function as a transcription factor during osteoblast differentiation of hMSC, we showed that the ZNF25 protein exhibits nuclear localization and is expressed in osteoblastic and osteocytic cells in vivo. ZNF25 is conserved in tetrapod vertebrates and contains a KRAB (Krueppel-associated box) transcriptional repressor domain. Conclusions: This study shows that the uncharacterized transcription factor, ZNF25, is associated with differentiation of hMSC to osteoblasts.

Published
2016

23. Effect of cell confluence on production of cloned mice using an inbred embryonic stem cell line

Author

GAO S., MCGARRY M., FERRIER T., PALLANTE B., FLETCHER J., HARKNESS L., DE SOUSA P. A., MCWHIR J., WILMUT I., GASPARRINI, BIANCA, Gao, S., Mcgarry, M., Ferrier, T., Pallante, B., Gasparrini, Bianca, Fletcher, J., Harkness, L., DE SOUSA, P. A., Mcwhir, J., and Wilmut, I.

Subjects
developmental biology, embryo, oocyte development
Abstract

Mice have been successfully cloned from both somatic cells and hybrid embryonic stem (ES) cells. Heterozygosity of the donor ES cell genome has been suggested as a crucial factor for long-term survival of cloned mice. In the present study, an inbred ES cell line, HM-1 (129/Ola), and a well-tested ES cell line, R1 (129/Sv x 129/Sv-CP), were used as donor cells to evaluate the developmental potential of nuclear transfer embryos. We found that ES cell confluence dramatically affects the developmental potential of reconstructed embryos. With the ES cell line HM-1 and 80-90% confluence, 49% of reconstructed embryos developed to the morula/blastocyst stage, 9% of these embryos developed to live pups when transferred to the surrogate mothers, and 5 of 18 live pups survived to adulthood. By contrast, at 60-70% confluence, only 22% of embryos developed to the morula/blastocyst stage, and after transfer, only a single fetus reached term. Consistent with previous reports, the nuclei of R1 ES cells were also shown to direct development to term, but no live pups were derived from cells at later passages (>20). Our results show that the developmental potential of reconstructed embryos is determined by both cell confluence and cell passage. These results also demonstrate that the inbred ES cell line, HM-1, can be used to produce viable cloned mice, although less efficiently than most heterozygous ES cell lines.

Published
2003

24. Germinal vesicle material is essential for nucleus remodeling after nuclear transfer

Author

GAO S., MCGARRY M., FERRIER P., FLETCHER J., HARKNESS L., DE SOUSA P. A., WILMUT I., GASPARRINI, BIANCA, Gao, S., Gasparrini, Bianca, Mcgarry, M., Ferrier, P., Fletcher, J., Harkness, L., DE SOUSA, P. A., and Wilmut, I.

Abstract

Successful cloning by nuclear transfer has been reported with somatic or embryonic stem (ES) cell nucleus injection into enucleated mouse metaphase II oocytes. In this study, we enucleated mouse oocytes at the germinal vesicle (GV) or pro-metaphase I (pro-MI) stage and cultured the cytoplasm to the MII stage. Nuclei from cells of the R1 ES cell line were injected into both types of cytoplasm to evaluate developmental potential of resulting embryos compared to MII cytoplasmic injection. Immunocytochemical staining revealed that a spindle started to organize 30 min after nucleus injection into all three types of cytoplasm. A well-organized bipolar spindle resembling an MII spindle was present in both pro-MI and MII cytoplasm 1 h after injection with ES cells. However, in the mature GV cytoplasm, chromosomes were distributed throughout the cytoplasm and a much bigger spindle was formed. Pseudopronucleus formation was observed in pro-MI and MII cytoplasm after activation treatment. Although no pronucleus formation was found in GV cytoplasm, chromosomes segregated into two groups in response to activation. Only 8.1% of reconstructed embryos with pro-MI cytoplasm developed to the morula stage after culture in CZB medium. In contrast, 53.5% of embryos reconstructed with MII cytoplasm developed to the morula/blastocyst stage, and 5.3% of transferred embryos developed to term. These results indicate that GV material is essential for nucleus remodeling after nuclear transfer.

Published
2002

25. Somatic cell nuclear transfer in the pig: control of pronuclear formation and integration with improved methods for activation and maintenance of pregnancy

Author

DE SOUSA P. A, DOBRINSKY J. R, ZHU J., ARCHIBALD A., AINSLIE A., BOSMA W., BOWERING J., BRACKEN J., FERRIER P, FLETCHER J, HARKNESS L., GASPARRINI, BIANCA, DE SOUSA, P. A., Dobrinsky, J. R., Zhu, J., Archibald, A., Ainslie, A., Bosma, W., Bowering, J., Bracken, J., Ferrier, P, Fletcher, J, Gasparrini, Bianca, and Harkness, L.

Abstract

To clone a pig from somatic cells, we first validated an electrical activation method for use on ovulated oocytes. We then evaluated delayed versus simultaneous activation (DA vs. SA) strategies, the use of 2 nuclear donor cells, and the use of cytoskeletal inhibitors during nuclear transfer. Using enucleated ovulated oocytes as cytoplasts for fetal fibroblast nuclei and transferring cloned embryos into a recipient within 2 h of activation, a 2-h delay between electrical fusion and activation yielded blastocysts more reliably and with a higher nuclear count than did SA. Comparable rates of development using DA were obtained following culture of embryos cloned from ovulated or in vitro-matured cytoplasts and fibroblast or cumulus nuclei. Treatment of cloned embryos with cytochalasin B (CB) postfusion and for 6 h after DA had no impact on blastocyst development as compared with CB treatment postfusion only. Inclusion of a microtubule inhibitor such as nocodozole with CB before and after DA improved nuclear retention and favored the formation of single pronuclei in experiments using a membrane dye to reliably monitor fusion. However, no improvement in blastocyst development was observed. Using fetal fibroblasts as nuclear donor cells, a live cloned piglet was produced in a pregnancy that was maintained by cotransfer of parthenogenetic embryos.

Published
2002

27. AGATA -Advanced GAmma Tracking Array

Author

Akkoyun, S., Algora, A., Alikhani, B., Ameil, F., Angelis, G. de, Arnold, L., Astier, A., Atac, Ayse, Aubert, Y., Aufranc, C., Austin, A., Aydin, S., Azaiez, F., Badoer, S., Balabanski, D. L., Barrientos, D., Baulieu, G., Baumann, R., Bazzacco, D., Beck, F. A., Beck, T., Bednarczyk, P., Bellato, M., Bentley, M. A., Benzoni, G., Berthier, R., Berti, L., Beunard, R., Bianco, G. Lo, Birkenbach, B., Bizzeti, P. G., Bizzeti-Sona, A. M., Blanc, F. Le, Blasco, J. M., Blasi, N., Bloor, D., Boiano, C., Borsato, M., Bortolato, D., Boston, A. J., Boston, H. C., Bourgault, P., Boutachkov, P., Bouty, A., Bracco, A., Brambilla, S., Brawn, I. P., Brondi, A., Broussard, S., Bruyneel, B., Bucurescu, D., Burrows, I., Burger, A., Cabaret, S., Cahan, B., Calore, E., Camera, F., Capsoni, A., Carrio, F., Casati, G., Castoldi, M., Cederwall, B., Cercus, J. -L, Chambert, V., Chambit, M. El, Chapman, R., Charles, L., Chavas, J., Clement, E., Cocconi, P., Coelli, S., Coleman-Smith, P. J., Colombo, A., Colosimo, S., Commeaux, C., Conventi, D., Cooper, R. J., Corsi, A., Cortesi, A., Costa, L., Crespi, F. C. L., Cresswell, J. R., Cullen, D. M., Curien, D., Czermak, A., Delbourg, D., Depalo, R., Descombes, T., Desesquelles, P., Detistov, P., Diarra, C., Didierjean, F., Dimmock, M. R., Doan, Q. T., Domingo-Pardo, C., Doncel, M., Dorangeville, F., Dosme, N., Drouen, Y., Duchêne, G., Dulny, B., Eberth, J., Edelbruck, P., Egea, J., Engert, T., Erduran, M. N., Erturk, S., Fanin, C., Fantinel, S., Farnea, E., Faul, T., Filliger, M., Filmer, F., Finck, Ch., France, G. de, Gadea, A., Gast, W., Geraci, A., Gerl, J., Gernhauser, R., Giannatiempo, A., Giaz, A., Gibelin, L., Givechev, A., Goel, N., Gonzalez, V., Gottardo, A., Grave, X., Grebosz, J., Griffiths, R., Grint, A. N., Gros, P., Guevara, L., Gulmini, M., Gorgen, A., Ha, H. T. M., Habermann, T., Harkness, L. J., Harroch, H., Hauschild, K., He, C., Hernandez-Prieto, A., Hervieu, B., Hess, H., Huyuk, T., Ince, E., Isocrate, R., Jaworski, G., Johnson, A., Jolie, J., Jones, P., Jonson, B., Joshi, P., Judson, D. S., Jungclaus, A., Kaci, M., Karkour, N., Karolak, M., Karkour, A., Kebbiri, M., Kempley, R. S., Khaplanov, A., Klupp, S., Kogimtzis, M., Kojouharov, I., Korichi, A., Korten, W., Kroll, Th., Krucken, R., Kurz, N., Ky, B. Y., Labiche, M., Lafay, X., Lavergne, L., Lazarus, I. H., Leboutelier, S., Lefebvre, F., Legay, E., Legeard, L., Lelli, F., Lenzi, S. M., Leoni, S., Lermitage, A., Lersch, D., Leske, J., Letts, S. C., Lhenoret, S., Lieder, R. M., Linget, D., Ljungvall, J., Lopez-Martens, A., Lotode, A., Lunardi, S., Maj, A., Marel, J. van der, Mariette, Y., Marginean, N., Marginean, R., Maron, G., Mather, A. R., Meczynski, W., Mendez, V., Medina, P., Melon, B., Menegazzo, R., Mengoni, D., Merchan, E., Mihailescu, L., Michelagnoli, C., Mierzejewski, J., Milechina, L., Million, B., Mitev, K., Molini, P., Montanari, D., Moon, S., Morbiducci, F., Moro, R., Morrall, P. S., Möller, O., Nannini, A., Napoli, D. R., Nelson, L., Nespolo, M., Ngo, V. L., Nicoletto, M., Nicolini, R., Noa, Y. Le, Nolan, P. J., Norman, M., Nyberg, Johan, Obertelli, A., Olariu, A., Orlandi, R., Oxley, D. C., Ozben, C., Ozille, M., Oziol, C., Pachoud, E., Palacz, M., Palin, J., Pancin, J., Parisel, C., Pariset, P., Pascovici, G., Peghin, R., Pellegri, L., Perego, A., Perrier, S., Petcu, M., Petkov, P., Petrache, C., Pierre, E., Pietralla, N., Pietri, S., Pignanelli, M., Piqueras, I., Podolyak, Z., Pouhalec, P. Le, Pouthas, J., Pugnere, D., Pucknell, V. F. E., Pullia, A., Quintana, B., Raine, R., Rainovski, G., Ramina, L., Rampazzo, G., Rana, G. La, Rebeschini, M., Recchia, F., Redon, N., Reese, M., Reiter, P., Regan, P. H., Riboldi, S., Richer, M., Rigato, M., Rigby, S., Ripamonti, G., Robinson, A. P., Robin, J., Roccaz, J., Ropert, J. -A, Rosse, B., Rossi Alvarez, C., Rosso, D., Rubio, B., Rudolph, D., Saillant, F., Sahin, E., Salomon, F., Salsac, M. -D, Salt, J., Salvato, G., Sampson, J., Sanchis, E., Santos, C., Schaffner, H., Schlarb, M., Scraggs, D. P., Seddon, D., Senyigit, M., Sigward, M. -H, Simpson, G., Simpson, J., Slee, M., Smith, J. F., Sona, P., Sowicki, B., Spolaore, P., Stahl, C., Stanios, T., Stefanova, E., Stezowski, O., Strachan, J., Suliman, G., Söderström, Pär-Anders, Tain, J. L., Tanguy, S., Tashenov, S., Theisen, Ch., Thornhill, J., Tomasi, F., Toniolo, N., Touzery, R., Travers, B., Triossi, A., Tripon, M., Tun-Lanoe, K. M. M., Turcato, M., Unsworth, C., Ur, C. A., Valiente-Dobon, J. J., Vandone, V., Vardaci, E., Venturelli, R., Veronese, F., Veyssiere, Ch., Viscione, E., Wadsworth, R., Walker, P. M., Warr, N., Weber, C., Weisshaar, D., Wells, D., Wieland, O., Wiens, A., Wittwer, G., Wollersheim, H. J., Zocca, F., Zamfir, N. V., Zieblinski, M., Zucchiatti, A., Akkoyun, S., Algora, A., Alikhani, B., Ameil, F., Angelis, G. de, Arnold, L., Astier, A., Atac, Ayse, Aubert, Y., Aufranc, C., Austin, A., Aydin, S., Azaiez, F., Badoer, S., Balabanski, D. L., Barrientos, D., Baulieu, G., Baumann, R., Bazzacco, D., Beck, F. A., Beck, T., Bednarczyk, P., Bellato, M., Bentley, M. A., Benzoni, G., Berthier, R., Berti, L., Beunard, R., Bianco, G. Lo, Birkenbach, B., Bizzeti, P. G., Bizzeti-Sona, A. M., Blanc, F. Le, Blasco, J. M., Blasi, N., Bloor, D., Boiano, C., Borsato, M., Bortolato, D., Boston, A. J., Boston, H. C., Bourgault, P., Boutachkov, P., Bouty, A., Bracco, A., Brambilla, S., Brawn, I. P., Brondi, A., Broussard, S., Bruyneel, B., Bucurescu, D., Burrows, I., Burger, A., Cabaret, S., Cahan, B., Calore, E., Camera, F., Capsoni, A., Carrio, F., Casati, G., Castoldi, M., Cederwall, B., Cercus, J. -L, Chambert, V., Chambit, M. El, Chapman, R., Charles, L., Chavas, J., Clement, E., Cocconi, P., Coelli, S., Coleman-Smith, P. J., Colombo, A., Colosimo, S., Commeaux, C., Conventi, D., Cooper, R. J., Corsi, A., Cortesi, A., Costa, L., Crespi, F. C. L., Cresswell, J. R., Cullen, D. M., Curien, D., Czermak, A., Delbourg, D., Depalo, R., Descombes, T., Desesquelles, P., Detistov, P., Diarra, C., Didierjean, F., Dimmock, M. R., Doan, Q. T., Domingo-Pardo, C., Doncel, M., Dorangeville, F., Dosme, N., Drouen, Y., Duchêne, G., Dulny, B., Eberth, J., Edelbruck, P., Egea, J., Engert, T., Erduran, M. N., Erturk, S., Fanin, C., Fantinel, S., Farnea, E., Faul, T., Filliger, M., Filmer, F., Finck, Ch., France, G. de, Gadea, A., Gast, W., Geraci, A., Gerl, J., Gernhauser, R., Giannatiempo, A., Giaz, A., Gibelin, L., Givechev, A., Goel, N., Gonzalez, V., Gottardo, A., Grave, X., Grebosz, J., Griffiths, R., Grint, A. N., Gros, P., Guevara, L., Gulmini, M., Gorgen, A., Ha, H. T. M., Habermann, T., Harkness, L. J., Harroch, H., Hauschild, K., He, C., Hernandez-Prieto, A., Hervieu, B., Hess, H., Huyuk, T., Ince, E., Isocrate, R., Jaworski, G., Johnson, A., Jolie, J., Jones, P., Jonson, B., Joshi, P., Judson, D. S., Jungclaus, A., Kaci, M., Karkour, N., Karolak, M., Karkour, A., Kebbiri, M., Kempley, R. S., Khaplanov, A., Klupp, S., Kogimtzis, M., Kojouharov, I., Korichi, A., Korten, W., Kroll, Th., Krucken, R., Kurz, N., Ky, B. Y., Labiche, M., Lafay, X., Lavergne, L., Lazarus, I. H., Leboutelier, S., Lefebvre, F., Legay, E., Legeard, L., Lelli, F., Lenzi, S. M., Leoni, S., Lermitage, A., Lersch, D., Leske, J., Letts, S. C., Lhenoret, S., Lieder, R. M., Linget, D., Ljungvall, J., Lopez-Martens, A., Lotode, A., Lunardi, S., Maj, A., Marel, J. van der, Mariette, Y., Marginean, N., Marginean, R., Maron, G., Mather, A. R., Meczynski, W., Mendez, V., Medina, P., Melon, B., Menegazzo, R., Mengoni, D., Merchan, E., Mihailescu, L., Michelagnoli, C., Mierzejewski, J., Milechina, L., Million, B., Mitev, K., Molini, P., Montanari, D., Moon, S., Morbiducci, F., Moro, R., Morrall, P. S., Möller, O., Nannini, A., Napoli, D. R., Nelson, L., Nespolo, M., Ngo, V. L., Nicoletto, M., Nicolini, R., Noa, Y. Le, Nolan, P. J., Norman, M., Nyberg, Johan, Obertelli, A., Olariu, A., Orlandi, R., Oxley, D. C., Ozben, C., Ozille, M., Oziol, C., Pachoud, E., Palacz, M., Palin, J., Pancin, J., Parisel, C., Pariset, P., Pascovici, G., Peghin, R., Pellegri, L., Perego, A., Perrier, S., Petcu, M., Petkov, P., Petrache, C., Pierre, E., Pietralla, N., Pietri, S., Pignanelli, M., Piqueras, I., Podolyak, Z., Pouhalec, P. Le, Pouthas, J., Pugnere, D., Pucknell, V. F. E., Pullia, A., Quintana, B., Raine, R., Rainovski, G., Ramina, L., Rampazzo, G., Rana, G. La, Rebeschini, M., Recchia, F., Redon, N., Reese, M., Reiter, P., Regan, P. H., Riboldi, S., Richer, M., Rigato, M., Rigby, S., Ripamonti, G., Robinson, A. P., Robin, J., Roccaz, J., Ropert, J. -A, Rosse, B., Rossi Alvarez, C., Rosso, D., Rubio, B., Rudolph, D., Saillant, F., Sahin, E., Salomon, F., Salsac, M. -D, Salt, J., Salvato, G., Sampson, J., Sanchis, E., Santos, C., Schaffner, H., Schlarb, M., Scraggs, D. P., Seddon, D., Senyigit, M., Sigward, M. -H, Simpson, G., Simpson, J., Slee, M., Smith, J. F., Sona, P., Sowicki, B., Spolaore, P., Stahl, C., Stanios, T., Stefanova, E., Stezowski, O., Strachan, J., Suliman, G., Söderström, Pär-Anders, Tain, J. L., Tanguy, S., Tashenov, S., Theisen, Ch., Thornhill, J., Tomasi, F., Toniolo, N., Touzery, R., Travers, B., Triossi, A., Tripon, M., Tun-Lanoe, K. M. M., Turcato, M., Unsworth, C., Ur, C. A., Valiente-Dobon, J. J., Vandone, V., Vardaci, E., Venturelli, R., Veronese, F., Veyssiere, Ch., Viscione, E., Wadsworth, R., Walker, P. M., Warr, N., Weber, C., Weisshaar, D., Wells, D., Wieland, O., Wiens, A., Wittwer, G., Wollersheim, H. J., Zocca, F., Zamfir, N. V., Zieblinski, M., and Zucchiatti, A.

Abstract

The Advanced GAmma Tracking Array (AGATA) is a European project to develop and operate the next generation gamma-ray spectrometer. AGATA is based on the technique of gamma-ray energy tracking in electrically segmented high-purity germanium crystals. This technique requires the accurate determination of the energy, time and position of every interaction as a gamma ray deposits its energy within the detector volume. Reconstruction of the full interaction path results in a detector with very high efficiency and excellent spectral response. The realisation of gamma-ray tracking and AGATA is a result of many technical advances. These include the development of encapsulated highly segmented germanium detectors assembled in a triple cluster detector cryostat, an electronics system with fast digital sampling and a data acquisition system to process the data at a high rate. The full characterisation of the crystals was measured and compared with detector-response simulations. This enabled pulse-shape analysis algorithms, to extract energy, time and position, to be employed. In addition, tracking algorithms for event reconstruction were developed. The first phase of AGATA is now complete and operational in its first physics campaign. In the future AGATA will be moved between laboratories in Europe and operated in a series of campaigns to take advantage of the different beams and facilities available to maximise its science output. The paper reviews all the achievements made in the AGATA project including all the necessary infrastructure to operate and support the spectrometer.

Published
2012
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29. Compton imaging with AGATA and SmartPET for DESPEC

Author

Moon, S, primary, Arnés, B Q, additional, Boston, A J, additional, Boston, H C, additional, Cresswell, J R, additional, Davinson, T, additional, Gadea, A, additional, Harkness, L J, additional, Judson, D S, additional, Lazarus, I, additional, Nolan, P J, additional, Page, R D, additional, Prieto, A H, additional, and Simpson, J, additional

Published
2011
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30. Erratum: Coulomb excitation of the proton-dripline nucleusNa20[Phys. Rev. C80, 044325 (2009)]

Author

Schumaker, M. A., primary, Cline, D., additional, Hackman, G., additional, Pearson, C. J., additional, Svensson, C. E., additional, Wu, C. Y., additional, Andreyev, A., additional, Austin, R. A. E., additional, Ball, G. C., additional, Bandyopadhyay, D., additional, Becker, J. A., additional, Boston, A. J., additional, Boston, H. C., additional, Buchmann, L., additional, Churchman, R., additional, Cifarelli, F., additional, Cooper, R. J., additional, Cross, D. S., additional, Dashdorj, D., additional, Demand, G. A., additional, Dimmock, M. R., additional, Drake, T. E., additional, Finlay, P., additional, Gallant, A. T., additional, Garrett, P. E., additional, Green, K. L., additional, Grint, A. N., additional, Grinyer, G. F., additional, Harkness, L. J., additional, Hayes, A. B., additional, Kanungo, R., additional, Lisetskiy, A. F., additional, Leach, K. G., additional, Lee, G., additional, Maharaj, R., additional, Martin, J.-P., additional, Moisan, F., additional, Morton, A. C., additional, Mythili, S., additional, Nelson, L., additional, Newman, O., additional, Nolan, P. J., additional, Orce, J. N., additional, Padilla-Rodal, E., additional, Phillips, A. A., additional, Porter-Peden, M., additional, Ressler, J. J., additional, Roy, R., additional, Ruiz, C., additional, Sarazin, F., additional, Scraggs, D. P., additional, Waddington, J. C., additional, Wan, J. M., additional, Whitbeck, A., additional, Williams, S. J., additional, and Wong, J., additional

Published
2010
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33. Coulomb excitation of the proton-dripline nucleusNa20

Author

Schumaker, M. A., primary, Cline, D., additional, Hackman, G., additional, Pearson, C. J., additional, Svensson, C. E., additional, Wu, C. Y., additional, Andreyev, A., additional, Austin, R. A. E., additional, Ball, G. C., additional, Bandyopadhyay, D., additional, Becker, J. A., additional, Boston, A. J., additional, Boston, H. C., additional, Buchmann, L., additional, Churchman, R., additional, Cifarelli, F., additional, Cooper, R. J., additional, Cross, D. S., additional, Dashdorj, D., additional, Demand, G. A., additional, Dimmock, M. R., additional, Drake, T. E., additional, Finlay, P., additional, Gallant, A. T., additional, Garrett, P. E., additional, Green, K. L., additional, Grint, A. N., additional, Grinyer, G. F., additional, Harkness, L. J., additional, Hayes, A. B., additional, Kanungo, R., additional, Lisetskiy, A. F., additional, Leach, K. G., additional, Lee, G., additional, Maharaj, R., additional, Martin, J. -P., additional, Moisan, F., additional, Morton, A. C., additional, Mythili, S., additional, Nelson, L., additional, Newman, O., additional, Nolan, P. J., additional, Orce, J. N., additional, Padilla-Rodal, E., additional, Phillips, A. A., additional, Porter-Peden, M., additional, Ressler, J. J., additional, Roy, R., additional, Ruiz, C., additional, Sarazin, F., additional, Scraggs, D. P., additional, Waddington, J. C., additional, Wan, J. M., additional, Whitbeck, A., additional, Williams, S. J., additional, and Wong, J., additional

Published
2009
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34. Development of the ProSPECTus semiconductor Compton camera for medical imaging

Author

Harkness, L., primary, Boston, A., additional, Boston, H., additional, Cresswell, J., additional, Filmer, F., additional, Groves, J., additional, Headspith, J., additional, Kemp, G., additional, Lazarus, I., additional, Jones, M., additional, Judson, D., additional, Nolan, P., additional, Sampson, J., additional, Scraggs, D., additional, and Simpson, J., additional

Published
2009
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35. First Results with TIGRESS and Accelerated Radioactive Ion Beams from ISAC: Coulomb Excitation of [sup 20,21,29]Na

Author

Schumaker, M. A., primary, Hurst, A. M., additional, Svensson, C. E., additional, Wu, C. Y., additional, Becker, J. A., additional, Cline, D., additional, Hackman, G., additional, Pearson, C. J., additional, Stoyer, M. A., additional, Andreyev, A., additional, Austin, R. A. E., additional, Ball, G. C., additional, Bandyopadhyay, D., additional, Barton, C. J., additional, Boston, A. J., additional, Boston, H. C., additional, Buchmann, L., additional, Churchman, R., additional, Cifarelli, F., additional, Colosimo, S. J., additional, Cooper, R. J., additional, Cross, D. S., additional, Dashdorj, D., additional, Demand, G. A., additional, Dimmock, M. R., additional, Djongolov, M., additional, Drake, T. E., additional, Finlay, P., additional, Gallant, A. T., additional, Garrett, P. E., additional, Gray-Jones, C., additional, Green, K. L., additional, Grint, A. N., additional, Grinyer, G. F., additional, Harkness, L. J., additional, Hayes, A. B., additional, Kanungo, R., additional, Leach, K. G., additional, Kulp, W. D., additional, Lisetskiy, A. F., additional, Lee, G., additional, Lloyd, S., additional, Maharaj, R., additional, Martin, J.-P., additional, Millar, B. A., additional, Moisan, F., additional, Morton, A. C., additional, Mythili, S., additional, Nelson, L., additional, Newman, O., additional, Nolan, P. J., additional, Orce, J. N., additional, Oxley, D. C., additional, Padilla-Rodal, E., additional, Phillips, A. A., additional, Porter-Peden, M., additional, Ressler, J. J., additional, Rigby, S. V., additional, Roy, R., additional, Ruiz, C., additional, Sarazin, F., additional, Scraggs, D. P., additional, Sumithrarachchi, C. S., additional, Triambak, S., additional, Waddington, J. C., additional, Walker, P. M., additional, Wan, J., additional, Whitbeck, A., additional, Williams, S. J., additional, Wong, J., additional, Wood, J. L., additional, McDaniel, Floyd D., additional, and Doyle, Barney L., additional

Published
2009
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36. A Semiconductor-Based Positron Emission Tomography System

Author

Oxley, D. C., primary, Boston, A. J., additional, Boston, H. C., additional, Cresswell, J. R., additional, Grint, A. N., additional, Harkness, L. J., additional, Jones, M., additional, Judson, D. S., additional, Nolan, P. J., additional, Slee, M., additional, Unsworth, C., additional, Lazarus, I. H., additional, and Baharuth-Ram, K., additional

Published
2009
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38. Coulomb excitation of radioactiveNa21and its stable mirrorNe21

Author

Schumaker, M. A., primary, Cline, D., additional, Hackman, G., additional, Morton, A. C., additional, Pearson, C. J., additional, Svensson, C. E., additional, Wu, C. Y., additional, Andreyev, A., additional, Austin, R. A. E., additional, Ball, G. C., additional, Bandyopadhyay, D., additional, Becker, J. A., additional, Boston, A. J., additional, Boston, H. C., additional, Buchmann, L., additional, Churchman, R., additional, Cifarelli, F., additional, Cooper, R. J., additional, Cross, D. S., additional, Dashdorj, D., additional, Demand, G. A., additional, Dimmock, M. R., additional, Drake, T. E., additional, Finlay, P., additional, Gallant, A. T., additional, Garrett, P. E., additional, Green, K. L., additional, Grint, A. N., additional, Grinyer, G. F., additional, Harkness, L. J., additional, Hayes, A. B., additional, Kanungo, R., additional, Leach, K. G., additional, Lee, G., additional, Maharaj, R., additional, Martin, J.-P., additional, Moisan, F., additional, Mythili, S., additional, Nelson, L., additional, Newman, O., additional, Nolan, P. J., additional, Orce, J. N., additional, Padilla-Rodal, E., additional, Phillips, A. A., additional, Porter-Peden, M., additional, Ressler, J. J., additional, Roy, R., additional, Ruiz, C., additional, Sarazin, F., additional, Scraggs, D. P., additional, Waddington, J. C., additional, Wan, J. M., additional, Whitbeck, A., additional, Williams, S. J., additional, and Wong, J., additional

Published
2008
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39. Qualitative and quantitative analysis of mixtures of compounds containing both hydrogen and deuterium

Author

Crespi, H. L, Harkness, L, Katz, J. J, Norman, G, and Saur, W

Subjects
Life Sciences
Abstract

Method allows qualitative and quantitative analysis of mixtures of partially deuterated compounds. Nuclear magnetic resonance spectroscopy determines location and amount of deuterium in organic compounds but not fully deuterated compounds. Mass spectroscopy can detect fully deuterated species but not the location.

Published
1969

43. Status and Performance of an AGATA asymmetric detector.

Author

Boston, A. J., Dimmock, M. R., Unsworth, C., Boston, H. C., Cooper, R. J., Grint, A. N., Harkness, L. J., Lazarus, I. H., Jones, M., Nolan, P. J., Oxley, D. C., Simpson, J., and Slee, M.

Subjects
DETECTORS, SECURITY systems, SENSOR networks, PHYSICS instruments, GERMANIUM crystals
Abstract

High-resolution gamma-ray detectors based on high-purity germanium crystals (HPGe) are one of the key workhorses of experimental nuclear science. The technical development of such detector technology has been dramatic in recent years. Large volume, high-granularity, electrically segmented HPGe detectors have been realised and a methodology to improve position sensitivity using pulse-shape analysis coupled with the novel technique of gamma-ray tracking has been developed. Collaborations have been established in Europe (AGATA) [1] and the USA (GRETA/GRETINA) [2] to build gamma-ray tracking spectrometers. This paper discusses the performance of the first AGATA (Advanced GAmma Tracking Array) asymmetric detector that has been tested at the University of Liverpool. The use of a fully digital data acquisition system has allowed detector charge pulse shapes from a selection of well defined photon interaction positions to be analysed, yielding important information on the position sensitivity of the detector. [ABSTRACT FROM AUTHOR]

Published
2009
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44. Performance of an AGATA asymmetric detector.

Author

Boston, A. J., Dimmock, M. R., Unsworth, C., Boston, H. C., Cooper, R. J., Grint, A. N., Harkness, L. J., Lazarus, I. H., Jones, M., Nolan, P. J., Oxley, D. C., Simpson, J., and Slee, M.

Subjects
GAMMA rays, SPECTRUM analysis, GERMANIUM crystals, PHOTONS, ELECTROMAGNETIC waves
Abstract

Each major technical advance in gamma-ray detection devices has resulted in significant new insights into the structure of atomic nuclei. The next major step in gamma-ray spectroscopy involves achieving the goal of a 4π ball of germanium detectors by using the technique of gamma-ray energy tracking in electrically segmented germanium crystals. The resulting spectrometer will have an unparalleled level of detection power for nuclear electromagnetic radiation. Collaborations have been established in Europe (AGATA) [1] and the USA (GRETA/GRETINA) [2] to build gamma-ray tracking spectrometers. This paper discusses the performance of the first AGATA (Advanced GAmma Tracking Array) asymmetric detector that has been tested at the University of Liverpool. The use of a fully digital data acquisition system has allowed detector charge pulse shapes from a selection of well defined photon interaction positions to be analysed, yielding important information on the position sensitivity of the detector. [ABSTRACT FROM AUTHOR]

Published
2008
Full Text
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