19 results on '"Haringhuizen, Annebeth W."'
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2. Effect of physical exercise on the hippocampus and global grey matter volume in breast cancer patients: A randomized controlled trial (PAM study)
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Haringhuizen, Annebeth W., van der Steeg, Wim A., Terheggen, Frederiek, Blanken-Peeters, Charlotte, Fliervoet, Harold, Schlooz-Vries, Margrethe S., Frakking, Tanja G., van Tilburg, Marc W.A., Oldenhuis, Corina, Sier, Maartje F., van der Pol, Carmen C., Tick, Lidwine W., van Holsteijn, Nel A., Koevoets, E.W., Geerlings, M.I., Monninkhof, E.M., Mandl, R., Witlox, L., van der Wall, E., Stuiver, M.M., Sonke, G.S., Velthuis, M.J., Jobsen, J.J., van der Palen, J., Bos, M.E.M.M., Göker, E., Menke-Pluijmers, M.B.E., Sommeijer, D.W., May, A.M., de Ruiter, M.B., and Schagen, S.B.
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- 2023
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3. Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to 5 Years after Diagnosis
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Epi Kanker Team B, Cancer, Biostatistiek Onderwijs, Apotheek Bereidingen, Anatomie, MS CGO, MS Hematologie, MS Medische Oncologie, Epi Kanker, JC onderzoeksprogramma Cancer, Smit, Karel C, Derksen, Jeroen W G, Stellato, Rebecca K, van Lanen, Anne-Sophie, Wesselink, Evertine, Belt, Eric J Th, Cloos-van Balen, Marissa, Coene, Peter Paul L O, Dekker, Jan Willem T, de Groot, Jan Willem, Haringhuizen, Annebeth W, van Halteren, Henk K, van Heek, Tjarda T, Helgason, Helgi H, Hendriks, Mathijs P, de Hingh, Ignace H J T, Hoekstra, Ronald, Houtsma, Danny, Janssen, Johan J B, Kok, Niels, Konsten, Joop L M, Los, Maartje, Meijerink, Martijn R, Mekenkamp, Leonie J M, Peeters, Koen C M J, Polée, Marco B, Rietbroek, Ron C, Schiphorst, Anandi H W, Schrauwen, Ruud W M, Schreinemakers, Jennifer, Sie, Mark P S, Simkens, Lieke, Sonneveld, Eric J A, Terheggen, Frederiek, Valkenburg-van Iersel, Liselot, Vles, Wouter J, Wasowicz-Kemps, Daria K, de Wilt, Johannes H W, Kok, Dieuwertje E, Winkels, Renate M, Kampman, Ellen, van Duijnhoven, Fränzel J B, Koopman, Miriam, May, Anne M, Epi Kanker Team B, Cancer, Biostatistiek Onderwijs, Apotheek Bereidingen, Anatomie, MS CGO, MS Hematologie, MS Medische Oncologie, Epi Kanker, JC onderzoeksprogramma Cancer, Smit, Karel C, Derksen, Jeroen W G, Stellato, Rebecca K, van Lanen, Anne-Sophie, Wesselink, Evertine, Belt, Eric J Th, Cloos-van Balen, Marissa, Coene, Peter Paul L O, Dekker, Jan Willem T, de Groot, Jan Willem, Haringhuizen, Annebeth W, van Halteren, Henk K, van Heek, Tjarda T, Helgason, Helgi H, Hendriks, Mathijs P, de Hingh, Ignace H J T, Hoekstra, Ronald, Houtsma, Danny, Janssen, Johan J B, Kok, Niels, Konsten, Joop L M, Los, Maartje, Meijerink, Martijn R, Mekenkamp, Leonie J M, Peeters, Koen C M J, Polée, Marco B, Rietbroek, Ron C, Schiphorst, Anandi H W, Schrauwen, Ruud W M, Schreinemakers, Jennifer, Sie, Mark P S, Simkens, Lieke, Sonneveld, Eric J A, Terheggen, Frederiek, Valkenburg-van Iersel, Liselot, Vles, Wouter J, Wasowicz-Kemps, Daria K, de Wilt, Johannes H W, Kok, Dieuwertje E, Winkels, Renate M, Kampman, Ellen, van Duijnhoven, Fränzel J B, Koopman, Miriam, and May, Anne M
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- 2024
4. Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to Five Years after Diagnosis
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Smit, Karel C., Derksen, Jeroen W.G., Stellato, Rebecca K., van Lanen, Anne-Sophie, Wesselink, Evertine, Belt, Eric J.T., Cloos-van Balen, Marissa, Coene, Peter Paul L.O., Dekker, Jan Willem T., de Groot, Jan Willem, Haringhuizen, Annebeth W., van Halteren, Henk K., van Heek, Tjarda T., Helgason, Helgi H., Hendriks, Mathijs P., de Hingh, Ignace H.J.T., Hoekstra, Ronald, Houtsma, Danny, Janssen, Johan J.B., Kok, Niels, Konsten, Joop L.M., Los, Maartje, Meijerink, Martijn R., Mekenkamp, Leonie J.M., Peeters, Koen C.M.J., Polée, Marco B., Rietbroek, Ron C., Schiphorst, Anandi H.W., Schrauwen, Ruud W.M., Schreinemakers, Jennifer, Sie, Mark P.S., Simkens, Lieke, Sonneveld, Eric J.A., Terheggen, Frederiek, Valkenburg-van Iersel, Liselot, Vles, Wouter J., Wasowicz-Kemps, Daria K., de Wilt, Johannes H.W., Kok, Dieuwertje E., Winkels, Renate M., Kampman, Ellen, van Duijnhoven, Fränzel J.B., Koopman, Miriam, May, Anne M., Smit, Karel C., Derksen, Jeroen W.G., Stellato, Rebecca K., van Lanen, Anne-Sophie, Wesselink, Evertine, Belt, Eric J.T., Cloos-van Balen, Marissa, Coene, Peter Paul L.O., Dekker, Jan Willem T., de Groot, Jan Willem, Haringhuizen, Annebeth W., van Halteren, Henk K., van Heek, Tjarda T., Helgason, Helgi H., Hendriks, Mathijs P., de Hingh, Ignace H.J.T., Hoekstra, Ronald, Houtsma, Danny, Janssen, Johan J.B., Kok, Niels, Konsten, Joop L.M., Los, Maartje, Meijerink, Martijn R., Mekenkamp, Leonie J.M., Peeters, Koen C.M.J., Polée, Marco B., Rietbroek, Ron C., Schiphorst, Anandi H.W., Schrauwen, Ruud W.M., Schreinemakers, Jennifer, Sie, Mark P.S., Simkens, Lieke, Sonneveld, Eric J.A., Terheggen, Frederiek, Valkenburg-van Iersel, Liselot, Vles, Wouter J., Wasowicz-Kemps, Daria K., de Wilt, Johannes H.W., Kok, Dieuwertje E., Winkels, Renate M., Kampman, Ellen, van Duijnhoven, Fränzel J.B., Koopman, Miriam, and May, Anne M.
- Abstract
Introduction: Physical activity (PA) is associated with higher quality of life and probably better prognosis among colorectal cancer (CRC) patients. This study focuses on determinants of PA among CRC patients from diagnosis until five years post-diagnosis.Methods: Sociodemographic and disease-related factors of participants of two large CRC cohort studies were combined. Moderate-to-vigorous PA during sport and leisure time (MVPA-SL) was measured at diagnosis (T0) and six, twelve, twenty-four, and sixty (T6 to T60) months post-diagnosis, using the SQUASH questionnaire. Mixed-effects models were performed to identify sociodemographic and disease-related determinants of MVPA-SL, separately for stage I-III colon (CC), stage I-III rectal cancer (RC), and stage IV CRC (T0 and T6 only). Associations were defined as consistently present when significant at ≥4 timepoints for the stage I-III subsets. MVPA-SL levels were compared with an age- and sex-matched sample of the general Dutch population.Results: In total, 2905 CC, 1459 RC and 436 stage IV CRC patients were included. Patients with higher fatigue scores, and women compared to men had consistently lower MVPA-SL levels over time, regardless of tumor type and stage. At T6, having a stoma was significantly associated with lower MVPA-SL among stage I-III RC patients. Systemic therapy and radiotherapy were not significantly associated with MVPA-SL changes at T6. Compared to the general population, MVPA-SL levels of CRC patients were lower at all timepoints, most notably at T6.Conclusions: Female sex and higher fatigue scores were consistent determinants of lower MVPA-SL levels among all CRC patients, and MVPA-SL levels were lowest at six months post-diagnosis. Our results can inform the design of intervention studies aimed at improving PA, and guide healthcare professionals in optimizing individualized support.
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- 2024
5. Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to Five Years after Diagnosis
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Smit, Karel C., primary, Derksen, Jeroen W.G., additional, Stellato, Rebecca K., additional, van Lanen, Anne-Sophie, additional, Wesselink, Evertine, additional, Belt, Eric J. Th., additional, Cloos-van Balen, Marissa, additional, Coene, Peter Paul L.O., additional, Dekker, Jan Willem T., additional, de Groot, Jan Willem, additional, Haringhuizen, Annebeth W., additional, van Halteren, Henk K., additional, van Heek, Tjarda T., additional, Helgason, Helgi H., additional, Hendriks, Mathijs P., additional, de Hingh, Ignace H.J.T., additional, Hoekstra, Ronald, additional, Houtsma, Danny, additional, Janssen, Johan J.B., additional, Kok, Niels, additional, Konsten, Joop L.M., additional, Los, Maartje, additional, Meijerink, Martijn R., additional, Mekenkamp, Leonie J.M., additional, Peeters, Koen C.M.J., additional, Polée, Marco B., additional, Rietbroek, Ron C., additional, Schiphorst, Anandi H.W., additional, Schrauwen, Ruud W.M., additional, Schreinemakers, Jennifer, additional, Sie, Mark P.S., additional, Simkens, Lieke, additional, Sonneveld, Eric J.A., additional, Terheggen, Frederiek, additional, Valkenburg-van Iersel, Liselot, additional, Vles, Wouter J., additional, Wasowicz-Kemps, Daria K., additional, de Wilt, Johannes H.W., additional, Kok, Dieuwertje E., additional, Winkels, Renate M., additional, Kampman, Ellen, additional, van Duijnhoven, Fränzel J.B., additional, Koopman, Miriam, additional, and May, Anne M., additional
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- 2023
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6. Effect of physical exercise on the hippocampus and global grey matter volume in breast cancer patients:A randomized controlled trial (PAM study)
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Koevoets, E. W., Geerlings, M. I., Monninkhof, E. M., Mandl, R., Witlox, L., van der Wall, E., Stuiver, M. M., Sonke, G. S., Velthuis, M. J., Jobsen, J. J., van der Palen, J., Bos, M. E.M.M., Göker, E., Menke-Pluijmers, M. B.E., Sommeijer, D. W., May, A. M., Haringhuizen, Annebeth W., van der Steeg, Wim A., Terheggen, Frederiek, Blanken-Peeters, Charlotte, Fliervoet, Harold, Schlooz-Vries, Margrethe S., Frakking, Tanja G., van Tilburg, Marc W.A., Oldenhuis, Corina, Sier, Maartje F., van der Pol, Carmen C., Tick, Lidwine W., van Holsteijn, Nel A., de Ruiter, M. B., Schagen, S. B., Koevoets, E. W., Geerlings, M. I., Monninkhof, E. M., Mandl, R., Witlox, L., van der Wall, E., Stuiver, M. M., Sonke, G. S., Velthuis, M. J., Jobsen, J. J., van der Palen, J., Bos, M. E.M.M., Göker, E., Menke-Pluijmers, M. B.E., Sommeijer, D. W., May, A. M., Haringhuizen, Annebeth W., van der Steeg, Wim A., Terheggen, Frederiek, Blanken-Peeters, Charlotte, Fliervoet, Harold, Schlooz-Vries, Margrethe S., Frakking, Tanja G., van Tilburg, Marc W.A., Oldenhuis, Corina, Sier, Maartje F., van der Pol, Carmen C., Tick, Lidwine W., van Holsteijn, Nel A., de Ruiter, M. B., and Schagen, S. B.
- Abstract
Background: Physical exercise in cancer patients is a promising intervention to improve cognition and increase brain volume, including hippocampal volume. We investigated whether a 6-month exercise intervention primarily impacts total hippocampal volume and additionally hippocampal subfield volumes, cortical thickness and grey matter volume in previously physically inactive breast cancer patients. Furthermore, we evaluated associations with verbal memory. Methods: Chemotherapy-exposed breast cancer patients (stage I-III, 2–4 years post diagnosis) with cognitive problems were included and randomized in an exercise intervention (n = 70, age = 52.5 ± 9.0 years) or control group (n = 72, age = 53.2 ± 8.6 years). The intervention consisted of 2x1 hours/week of supervised aerobic and strength training and 2x1 hours/week Nordic or power walking. At baseline and at 6-month follow-up, volumetric brain measures were derived from 3D T1-weighted 3T magnetic resonance imaging scans, including hippocampal (subfield) volume (FreeSurfer), cortical thickness (CAT12), and grey matter volume (voxel-based morphometry CAT12). Physical fitness was measured with a cardiopulmonary exercise test. Memory functioning was measured with the Hopkins Verbal Learning Test-Revised (HVLT-R total recall) and Wordlist Learning of an online cognitive test battery, the Amsterdam Cognition Scan (ACS Wordlist Learning). An explorative analysis was conducted in highly fatigued patients (score of ≥ 39 on the symptom scale ‘fatigue’ of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire), as previous research in this dataset has shown that the intervention improved cognition only in these patients. Results: Multiple regression analyses and voxel-based morphometry revealed no significant intervention effects on brain volume, although at baseline increased physical fitness was significantly related to larger brain volume (e.g., total hippocampal volume: R = 0.32, B =
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- 2023
7. Effect of physical exercise on the hippocampus and global grey matter volume in breast cancer patients: A randomized controlled trial (PAM study)
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Koevoets, E.W., primary, Geerlings, M.I., additional, Monninkhof, E.M., additional, Mandl, R., additional, Witlox, L., additional, van der Wall, E., additional, Stuiver, M.M., additional, Sonke, G.S., additional, Velthuis, M.J., additional, Jobsen, J.J., additional, van der Palen, J., additional, Bos, M.E.M.M., additional, Göker, E., additional, Menke-Pluijmers, M.B.E., additional, Sommeijer, D.W., additional, May, A.M., additional, de Ruiter, M.B., additional, Schagen, S.B., additional, Haringhuizen, Annebeth W., additional, van der Steeg, Wim A., additional, Terheggen, Frederiek, additional, Blanken-Peeters, Charlotte, additional, Fliervoet, Harold, additional, Schlooz-Vries, Margrethe S., additional, Frakking, Tanja G., additional, van Tilburg, Marc W.A., additional, Oldenhuis, Corina, additional, Sier, Maartje F., additional, van der Pol, Carmen C., additional, Tick, Lidwine W., additional, and van Holsteijn, Nel A., additional
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- 2023
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8. Physical Activity Is Associated with Improved Overall Survival among Patients with Metastatic Colorectal Cancer
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Smit, Karel C., Derksen, Jeroen W.G., Beets, Geerard L.O., Belt, Eric J.Th, Berbée, Maaike, Coene, Peter Paul L.O., Van Cruijsen, Hester, Davidis, Marjan A., Dekker, Jan Willem T., Van Dodewaard-De Jong, Joyce M., Haringhuizen, Annebeth W., Helgason, Helgi H., Hendriks, Mathijs P., Hoekstra, Ronald, De Hingh, Ignace H.J.T., Ijzermans, Jan N.M., Janssen, Johan J.B., Konsten, Joop L.M., Los, Maartje, Mekenkamp, Leonie J.M., Nieboer, Peter, Peeters, Koen C.M.J., Peters, Natascha A.J.B., Pruijt, Hans J.F.M., Van Ufford-Mannesse, Patricia Quarles, Rietbroek, Ron C., Schiphorst, Anandi H.W., Van Der Velden, Arjan Schouten, Schrauwen, Ruud W.M., Sie, Mark P.S., Sommeijer, Dirkje W., Sonneveld, Dirk J.A., Stockmann, Hein B.A.C., Tent, Marleen, Terheggen, Frederiek, Tjin-A-Ton, Manuel L.R., Valkenburg-Van Iersel, Liselot, Van Der Velden, Ankie M.T., Vles, Wouter J., Van Voorthuizen, Theo, Wegdam, Johannes A., De Wilt, Johannes H.W., Koopman, Miriam, May, Anne M., Smit, Karel C., Derksen, Jeroen W.G., Beets, Geerard L.O., Belt, Eric J.Th, Berbée, Maaike, Coene, Peter Paul L.O., Van Cruijsen, Hester, Davidis, Marjan A., Dekker, Jan Willem T., Van Dodewaard-De Jong, Joyce M., Haringhuizen, Annebeth W., Helgason, Helgi H., Hendriks, Mathijs P., Hoekstra, Ronald, De Hingh, Ignace H.J.T., Ijzermans, Jan N.M., Janssen, Johan J.B., Konsten, Joop L.M., Los, Maartje, Mekenkamp, Leonie J.M., Nieboer, Peter, Peeters, Koen C.M.J., Peters, Natascha A.J.B., Pruijt, Hans J.F.M., Van Ufford-Mannesse, Patricia Quarles, Rietbroek, Ron C., Schiphorst, Anandi H.W., Van Der Velden, Arjan Schouten, Schrauwen, Ruud W.M., Sie, Mark P.S., Sommeijer, Dirkje W., Sonneveld, Dirk J.A., Stockmann, Hein B.A.C., Tent, Marleen, Terheggen, Frederiek, Tjin-A-Ton, Manuel L.R., Valkenburg-Van Iersel, Liselot, Van Der Velden, Ankie M.T., Vles, Wouter J., Van Voorthuizen, Theo, Wegdam, Johannes A., De Wilt, Johannes H.W., Koopman, Miriam, and May, Anne M.
- Abstract
Regular physical activity (PA) is associated with improved overall survival (OS) in stage I-III colorectal cancer (CRC) patients. This association is less defined in patients with metastatic CRC (mCRC). We therefore conducted a study in mCRC patients participating in the Prospective Dutch Colorectal Cancer cohort. PA was assessed with the validated SQUASH questionnaire, filled-in within a maximum of 60 days after diagnosis of mCRC. PA was quantified by calculating Metabolic Equivalent Task (MET) hours per week. American College of Sports and Medicine (ACSM) PA guideline adherence, tertiles of moderate to vigorous PA (MVPA), and sport and leisure time MVPA (MVPA-SL) were assessed as well. Vital status was obtained from the municipal population registry. Cox proportional-hazards models were used to study the association between PA determinants and all-cause mortality adjusted for prognostic patient and treatment-related factors. In total, 293 mCRC patients (mean age 62.9±10.6 years, 67% male) were included in the analysis. Compared to low levels, moderate and high levels of MET-hours were significantly associated with longer OS (fully adjusted hazard ratios: 0.491, (95% CI 0.299-0.807, p value=0.005) and 0.485 (95% CI 0.303-0.778, p value=0.003), respectively), as were high levels of MVPA (0.476 (95% CI 0.278-0.816, p value=0.007)) and MVPA-SL (0.389 (95% CI 0.224-0.677, p value<0.001)), and adherence to ACSM PA guidelines compared to non-adherence (0.629 (95% CI 0.412-0.961, p value=0.032)). The present study provides evidence that higher PA levels at diagnosis of mCRC are associated with longer OS.
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- 2022
9. Physical Activity Is Associated with Improved Overall Survival among Patients with Metastatic Colorectal Cancer
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Epi Kanker Team B, Cancer, MS Medische Oncologie, Epidemiology & Health Economics, JC onderzoeksprogramma Kanker, Smit, Karel C, Derksen, Jeroen W G, Beets, Geerard L O, Belt, Eric J Th, Berbée, Maaike, Coene, Peter Paul L O, van Cruijsen, Hester, Davidis, Marjan A, Dekker, Jan Willem T, van Dodewaard-de Jong, Joyce M, Haringhuizen, Annebeth W, Helgason, Helgi H, Hendriks, Mathijs P, Hoekstra, Ronald, de Hingh, Ignace H J T, IJzermans, Jan N M, Janssen, Johan J B, Konsten, Joop L M, Los, Maartje, Mekenkamp, Leonie J M, Nieboer, Peter, Peeters, Koen C M J, Peters, Natascha A J B, Pruijt, Hans J F M, Quarles van Ufford-Mannesse, Patricia, Rietbroek, Ron C, Schiphorst, Anandi H W, Schouten van der Velden, Arjan, Schrauwen, Ruud W M, Sie, Mark P S, Sommeijer, Dirkje W, Sonneveld, Dirk J A, Stockmann, Hein B A C, Tent, Marleen, Terheggen, Frederiek, Tjin-A-Ton, Manuel L R, Valkenburg-van Iersel, Liselot, van der Velden, Ankie M T, Vles, Wouter J, van Voorthuizen, Theo, Wegdam, Johannes A, de Wilt, Johannes H W, Koopman, Miriam, May, Anne M, On Behalf Of The Plcrc Study Group, Epi Kanker Team B, Cancer, MS Medische Oncologie, Epidemiology & Health Economics, JC onderzoeksprogramma Kanker, Smit, Karel C, Derksen, Jeroen W G, Beets, Geerard L O, Belt, Eric J Th, Berbée, Maaike, Coene, Peter Paul L O, van Cruijsen, Hester, Davidis, Marjan A, Dekker, Jan Willem T, van Dodewaard-de Jong, Joyce M, Haringhuizen, Annebeth W, Helgason, Helgi H, Hendriks, Mathijs P, Hoekstra, Ronald, de Hingh, Ignace H J T, IJzermans, Jan N M, Janssen, Johan J B, Konsten, Joop L M, Los, Maartje, Mekenkamp, Leonie J M, Nieboer, Peter, Peeters, Koen C M J, Peters, Natascha A J B, Pruijt, Hans J F M, Quarles van Ufford-Mannesse, Patricia, Rietbroek, Ron C, Schiphorst, Anandi H W, Schouten van der Velden, Arjan, Schrauwen, Ruud W M, Sie, Mark P S, Sommeijer, Dirkje W, Sonneveld, Dirk J A, Stockmann, Hein B A C, Tent, Marleen, Terheggen, Frederiek, Tjin-A-Ton, Manuel L R, Valkenburg-van Iersel, Liselot, van der Velden, Ankie M T, Vles, Wouter J, van Voorthuizen, Theo, Wegdam, Johannes A, de Wilt, Johannes H W, Koopman, Miriam, May, Anne M, and On Behalf Of The Plcrc Study Group
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- 2022
10. Effect of physical exercise on cognitive function after chemotherapy in patients with breast cancer: a randomized controlled trial (PAM study)
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Koevoets, E. W., Schagen, S. B., de Ruiter, M. B., Geerlings, M. I., Witlox, L., van der Wall, E., Stuiver, M. M., Sonke, G. S., Velthuis, M. J., Jobsen, J. J., Menke-Pluijmers, M. B. E., Göker, E., van der Pol, C. C., Bos, M. E. M. M., Tick, L. W., van Holsteijn, N. A., van der Palen, J., May, A. M., Monninkhof, E. M., Haringhuizen, Annebeth W., van der Steeg, Wim A., Sommeijer, Dirkje W., Terheggen, Frederiek, Blanken-Peeters, Charlotte, Fliervoet, Harold, Schlooz-Vries, Margrethe S., Frakking, Tanja G., van Tilburg, Marc W. A., Oldenhuis, Corina, Sier, Maartje F., VU University medical center, APH - Quality of Care, APH - Health Behaviors & Chronic Diseases, Medical Oncology, Cognition, Data and Education, Psychology Other Research (FMG), Radiology and Nuclear Medicine, General practice, Master Evidence Based Practice, CCA - Cancer Treatment and Quality of Life, Oncology, APH - Personalized Medicine, and APH - Aging & Later Life
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Strength exercise ,Cognitive complaints ,Physical exercise ,Breast Neoplasms ,Physical fitness ,Oxygen ,Exercise training ,Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] ,Oxygen Consumption ,Treatment Outcome ,Breast cancer ,Cognition ,SDG 3 - Good Health and Well-being ,Quality of Life ,Humans ,Female ,Exercise ,Fatigue ,Aerobic exercise ,Cancer-related cognitive impairment - Abstract
Background Up to 60% of breast cancer patients treated with chemotherapy is confronted with cognitive problems, which can have a significant impact on daily activities and quality of life (QoL). We investigated whether exercise training improves cognition in chemotherapy-exposed breast cancer patients 2–4 years after diagnosis. Methods Chemotherapy-exposed breast cancer patients, with both self-reported cognitive problems and lower than expected performance on neuropsychological tests, were randomized to an exercise or control group. The 6-month exercise intervention consisted of supervised aerobic and strength training (2 h/week), and Nordic/power walking (2 h/week). Our primary outcome was memory functioning (Hopkins Verbal Learning Test-Revised; HVLT-R). Secondary outcomes included online neuropsychological tests (Amsterdam Cognition Scan; ACS), self-reported cognition (MD Anderson Symptom Inventory for multiple myeloma; MDASI-MM), physical fitness (relative maximum oxygen uptake; VO2peak), fatigue (Multidimensional Fatigue Inventory), QoL (European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire; EORTC QLQ C-30), depression (Patient Health Questionnaire-9, Hospital Anxiety and Depression Scale; HADS), and anxiety (HADS). HVLT-R total recall was analyzed with a Fisher exact test for clinically relevant improvement (≥ 5 words). Other outcomes were analyzed using multiple regression analyses adjusted for baseline and stratification factors. Results We randomized 181 patients to the exercise (n = 91) or control group (n = 90). Two-third of the patients attended ≥ 80% of the exercise sessions, and physical fitness significantly improved compared to control patients (B VO2peak 1.4 ml/min/kg, 95%CI:0.6;2.2). No difference in favor of the intervention group was seen on the primary outcome. Significant beneficial intervention effects were found for self-reported cognitive functioning [MDASI-MM severity (B-0.7, 95% CI − 1.2; − 0.1)], fatigue, QoL, and depression. A hypothesis-driven analysis in highly fatigued patients showed positive exercise effects on tested cognitive functioning [ACS Reaction Time (B-26.8, 95% CI − 52.9; − 0.6) and ACS Wordlist Learning (B4.4, 95% CI 0.5; 8.3)]. Conclusions A 6-month exercise intervention improved self-reported cognitive functioning, physical fitness, fatigue, QoL, and depression in chemotherapy-exposed breast cancer patients with cognitive problems. Tested cognitive functioning was not affected. However, subgroup analysis indicated a positive effect of exercise on tested cognitive functioning in highly fatigued patients. Trial Registration Netherlands Trial Registry: Trial NL5924 (NTR6104). Registered 24 October 2016, https://www.trialregister.nl/trial/5924.
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- 2022
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11. Work Ability in Patients With Stage I to IV Colon Cancer: Results of the Dutch Prospective Colorectal Cancer Cohort.
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Franken, Mira D., Vink, Geraldine, van Grevenstein, Wilhelmina M.U., Verkooijen, Helena M., Punt, Cornelis J.A., Koopman, Miriam, May, Anne M., Beets, Geerard L., Belt, Eric J.Th., Berbée, Maaike, Beverdam, Frederique H., Blankenburgh, Ruud, Coene, Peter Paul L.O., de Groot, Jan Willem B., de Hingh, Ignace H.J.T., de Vos, Aad I., de Wilt, Johannes H.W., Dekker, Jan Willem T., Erdkamp, Frans L.G., and Haringhuizen, Annebeth W.
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- 2023
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12. Trajectories of health-related quality of life and psychological distress in patients with colorectal cancer: A population-based study
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Qaderi, Seyed M., primary, van der Heijden, Joost A.G., additional, Verhoeven, Rob H.A., additional, de Wilt, Johannes H.W., additional, Custers, Jose A.E., additional, Beets, Geerard L., additional, Belt, Eric J.Th., additional, Berbée, Maaike, additional, Beverdam, Frederique H., additional, Blankenburgh, Ruud, additional, Coene, Peter Paul L.O., additional, de Groot, Jan Willem B., additional, de Hingh, Ignace H.J.T., additional, de Vos, Aad I., additional, Dekker, Jan Willem T., additional, Erdkamp, Frans L.G., additional, Haringhuizen, Annebeth W., additional, Helgason, Helgi H., additional, Hendriks, Mathijs P., additional, Hoekstra, Ronald, additional, Ijzermans, Jan N.M., additional, Jansen, Jan, additional, Kloppenberg, Frank W.H., additional, Los, Maartje, additional, Meijerink, Martijn R., additional, Mekenkamp, Leonie J.M., additional, Nieboer, Peter, additional, Peeters, Koen C.M.J., additional, Peters, Natascha A.J.B., additional, Polée, Marco B., additional, Pruijt, Johannes F.M., additional, van Ufford-Mannesse, Patricia Quarles, additional, Rietbroek, Ron C., additional, Schiphorst, Anandi H.W., additional, van der Velden, Arjan Schouten, additional, Schrauwen, Ruud W.M., additional, Sie, Mark P.S., additional, Simkens, Lieke, additional, Sommeijer, Dirkje W., additional, Sonneveld, Dirk J.A., additional, Spierings, Leontine E.A., additional, Stockmann, Hein B.A.C., additional, Talsma, Koen, additional, ten Tije, Albert J., additional, Terheggen, Frederiek, additional, Tjin-A-Ton, Manuel L.R., additional, Valkenburg-van Iersel, Liselot B.J., additional, van Cruijsen, Hester, additional, Velden, Ankie M.T. van der, additional, van Dodewaard-de Jong, Joyce M., additional, van Lent, Anja U.G., additional, van Voorthuizen, Theo, additional, Vermaas, Maarten, additional, Vles, Wouter J., additional, Vogelaar, Jeroen F.J., additional, and Zimmerman, David D.E., additional
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- 2021
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13. The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care
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Derksen, Jeroen W. G., Vink, Geraldine R., Elferink, Marloes A. G., Roodhart, Jeanine M. L., Verkooijen, Helena M., van Grevenstein, Wilhelmina M. U., Siersema, Peter D., May, Anne M., Koopman, Miriam, Beets, Geerard L., Belt, Eric J. Th., Berbée, Maaike, Beverdam, Frederique H., Blankenburgh, Ruud, Coene, Peter Paul L. O., van Cruijsen, Hester, Dekker, Jan Willem T., van Dodewaard-de Jong, Joyce M., Erdkamp, Frans L. G., de Groot, Jan Willem B., Haringhuizen, Annebeth W., Helgason, Helgi H., Hendriks, Mathijs P., de Hingh, Ignace H. J. T., Hoekstra, Ronald, Ijzermans, Jan N. M., Jansen, Jan, Kloppenberg, Frank W. H., van Lent, Anja U. G., Los, Maartje, Meijerink, Martijn R., Mekenkamp, Leonie J. M., Nieboer, Peter, Peeters, Koen C. M. J., Peters, Natascha A. J. B., Polée, Marco B., Pruijt, Johannes F. M., Punt, Cornelis J. A., van Ufford-Mannesse, Patricia Quarles, Rietbroek, Ron C., Schiphorst, Anandi H. W., van der Velden, Arjan Schouten, Schrauwen, Ruud W. M., Sie, Mark P. S., Simkens, Lieke, Sommeijer, Dirkje W., Sonneveld, Dirk J. A., Spierings, Leontine E. A., Stockmann, Hein B. A. C., Talsma, Koen, Terheggen, Frederiek, ten Tije, Albert J., Tjin-A-Ton, Manuel L. R., Valkenburg-van Iersel, Liselot B. J., Veenstra, Renzo P., van der Velden, Ankie M. T., Vermaas, Maarten, Vles, Wouter J., Vogelaar, Jeroen F. J., van Voorthuizen, Theo, de Vos, Aad I., Wegdam, Johannes A., de Wilt, Johannes H. W., Zimmerman, David D. E., Surgery, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Epidemiologie, CCA - Cancer Treatment and quality of life, Radiology and nuclear medicine, Internal medicine, and VU University medical center
- Subjects
Male ,medicine.medical_specialty ,Colorectal cancer ,Epidemiology ,Science ,Population ,MODELS ,MEDLINE ,Logistic regression ,Representativeness heuristic ,Article ,03 medical and health sciences ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,0302 clinical medicine ,Cancer epidemiology ,Medical research ,All institutes and research themes of the Radboud University Medical Center ,SDG 3 - Good Health and Well-being ,Multidisciplinary approach ,COLON ,medicine ,Humans ,030212 general & internal medicine ,Prospective Studies ,Registries ,education ,Aged ,Netherlands ,Aged, 80 and over ,education.field_of_study ,Multidisciplinary ,business.industry ,Middle Aged ,medicine.disease ,Cancer registry ,TRIALS ,Outcomes research ,030220 oncology & carcinogenesis ,Family medicine ,Cohort ,Medicine ,Female ,business ,Colorectal Neoplasms - Abstract
Real-world data (RWD) sources are important to advance clinical oncology research and evaluate treatments in daily practice. Since 2013, the Prospective Dutch Colorectal Cancer (PLCRC) cohort, linked to the Netherlands Cancer Registry, serves as an infrastructure for scientific research collecting additional patient-reported outcomes (PRO) and biospecimens. Here we report on cohort developments and investigate to what extent PLCRC reflects the “real-world”. Clinical and demographic characteristics of PLCRC participants were compared with the general Dutch CRC population (n = 74,692, Dutch-ref). To study representativeness, standardized differences between PLCRC and Dutch-ref were calculated, and logistic regression models were evaluated on their ability to distinguish cohort participants from the Dutch-ref (AU-ROC 0.5 = preferred, implying participation independent of patient characteristics). Stratified analyses by stage and time-period (2013–2016 and 2017–Aug 2019) were performed to study the evolution towards RWD. In August 2019, 5744 patients were enrolled. Enrollment increased steeply, from 129 participants (1 hospital) in 2013 to 2136 (50 of 75 Dutch hospitals) in 2018. Low AU-ROC (0.65, 95% CI: 0.64–0.65) indicates limited ability to distinguish cohort participants from the Dutch-ref. Characteristics that remained imbalanced in the period 2017–Aug’19 compared with the Dutch-ref were age (65.0 years in PLCRC, 69.3 in the Dutch-ref) and tumor stage (40% stage-III in PLCRC, 30% in the Dutch-ref). PLCRC approaches to represent the Dutch CRC population and will ultimately meet the current demand for high-quality RWD. Efforts are ongoing to improve multidisciplinary recruitment which will further enhance PLCRC’s representativeness and its contribution to a learning healthcare system.
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- 2021
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14. Survival of patients with deficient mismatch repair metastatic colorectal cancer in the pre-immunotherapy era
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Verpleegafdeling Medische Oncologie, Onderzoek Medische Oncologie, Cancer, Epidemiology & Health Economics, JC onderzoeksprogramma Kanker, MS Medische Oncologie, Wensink, G Emerens, Elferink, Marloes A G, May, Anne M, Mol, Linda, Hamers, Patricia A H, Bakker, Sandra D, Creemers, Geert-Jan, de Groot, Jan Willem B, de Klerk, Gerty J, Haberkorn, Brigitte C M, Haringhuizen, Annebeth W, Hoekstra, Ronald, Hunting, J Cornelis B, Kerver, Emile D, Mathijssen-van Stein, Danielle, Polée, Marco B, Pruijt, Johannes F M, Quarles van Ufford-Mannesse, Patricia, Radema, Sandra, Rietbroek, Ronald C, Simkens, Lieke H J, Tanis, Bea C, Ten Bokkel Huinink, Daan, Tjin-A-Ton, Manuel L R, Tromp-van Driel, Cathrien S, Troost, Monique M, van de Wouw, Agnes J, van den Berkmortel, Franchette W P J, van der Pas, Anke J M, van der Velden, Ankie M T, van Dijk, Marjan A, van Dodewaard-de Jong, Joyce M, van Druten, Edith B, van Voorthuizen, Theo, Jan Veldhuis, Gerrit, Verheul, Henk M W, Vestjens, Hanneke J H M J, Vincent, Jeroen, Kranenburg, Onno W, Punt, Cornelis J A, Vink, Geraldine R, Roodhart, Jeanine M L, Koopman, Miriam, Verpleegafdeling Medische Oncologie, Onderzoek Medische Oncologie, Cancer, Epidemiology & Health Economics, JC onderzoeksprogramma Kanker, MS Medische Oncologie, Wensink, G Emerens, Elferink, Marloes A G, May, Anne M, Mol, Linda, Hamers, Patricia A H, Bakker, Sandra D, Creemers, Geert-Jan, de Groot, Jan Willem B, de Klerk, Gerty J, Haberkorn, Brigitte C M, Haringhuizen, Annebeth W, Hoekstra, Ronald, Hunting, J Cornelis B, Kerver, Emile D, Mathijssen-van Stein, Danielle, Polée, Marco B, Pruijt, Johannes F M, Quarles van Ufford-Mannesse, Patricia, Radema, Sandra, Rietbroek, Ronald C, Simkens, Lieke H J, Tanis, Bea C, Ten Bokkel Huinink, Daan, Tjin-A-Ton, Manuel L R, Tromp-van Driel, Cathrien S, Troost, Monique M, van de Wouw, Agnes J, van den Berkmortel, Franchette W P J, van der Pas, Anke J M, van der Velden, Ankie M T, van Dijk, Marjan A, van Dodewaard-de Jong, Joyce M, van Druten, Edith B, van Voorthuizen, Theo, Jan Veldhuis, Gerrit, Verheul, Henk M W, Vestjens, Hanneke J H M J, Vincent, Jeroen, Kranenburg, Onno W, Punt, Cornelis J A, Vink, Geraldine R, Roodhart, Jeanine M L, and Koopman, Miriam
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- 2021
15. Survival of patients with deficient mismatch repair metastatic colorectal cancer in the pre-immunotherapy era
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Wensink, G. Emerens, primary, Elferink, Marloes A. G., additional, May, Anne M., additional, Mol, Linda, additional, Hamers, Patricia A. H., additional, Bakker, Sandra D., additional, Creemers, Geert-Jan, additional, de Groot, Jan Willem B., additional, de Klerk, Gerty J., additional, Haberkorn, Brigitte C. M., additional, Haringhuizen, Annebeth W., additional, Hoekstra, Ronald, additional, Hunting, J. Cornelis B., additional, Kerver, Emile D., additional, Mathijssen-van Stein, Danielle, additional, Polée, Marco B., additional, Pruijt, Johannes F. M., additional, Quarles van Ufford-Mannesse, Patricia, additional, Radema, Sandra, additional, Rietbroek, Ronald C., additional, Simkens, Lieke H. J., additional, Tanis, Bea C., additional, ten Bokkel Huinink, Daan, additional, Tjin-A-Ton, Manuel L. R., additional, Tromp-van Driel, Cathrien S., additional, Troost, Monique M., additional, van de Wouw, Agnes J., additional, van den Berkmortel, Franchette W. P. J., additional, van der Pas, Anke J. M., additional, van der Velden, Ankie M. T., additional, van Dijk, Marjan A., additional, van Dodewaard-de Jong, Joyce M., additional, van Druten, Edith B., additional, van Voorthuizen, Theo, additional, Jan Veldhuis, Gerrit, additional, Verheul, Henk M. W., additional, Vestjens, Hanneke J. H. M. J., additional, Vincent, Jeroen, additional, Kranenburg, Onno W., additional, Punt, Cornelis J. A., additional, Vink, Geraldine R., additional, Roodhart, Jeanine M. L., additional, and Koopman, Miriam, additional
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- 2020
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16. Survival of patients with deficient mismatch repair metastatic colorectal cancer in the pre-immunotherapy era.
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Wensink, G. Emerens, Elferink, Marloes A. G., May, Anne M., Mol, Linda, Hamers, Patricia A. H., Bakker, Sandra D., Creemers, Geert-Jan, de Groot, Jan Willem B., de Klerk, Gerty J., Haberkorn, Brigitte C. M., Haringhuizen, Annebeth W., Hoekstra, Ronald, Hunting, J. Cornelis B., Kerver, Emile D., Mathijssen-van Stein, Danielle, Polée, Marco B., Pruijt, Johannes F. M., Quarles van Ufford-Mannesse, Patricia, Radema, Sandra, and Rietbroek, Ronald C.
- Abstract
Background: Metastatic colorectal cancer patients with deficient mismatch repair (dMMR mCRC) benefit from immunotherapy. Interpretation of the single-arm immunotherapy trials is complicated by insignificant survival data during systemic non-immunotherapy. We present survival data on a large, comprehensive cohort of dMMR mCRC patients, treated with or without systemic non-immunotherapy.Methods: Two hundred and eighty-one dMMR mCRC patients (n = 54 from three prospective Phase 3 CAIRO trials; n = 227 from the Netherlands Cancer Registry). Overall survival was analysed from diagnosis of mCRC (OS), from initiation of first-line (OS1) and second-line (OS2) systemic treatment. Cox regression analysis examined prognostic factors. As comparison for OS 2746 MMR proficient mCRC patients were identified.Results: Of 281 dMMR patients, 62% received first-line and 26% second-line treatment. Median OS was 16.0 months (13.8-19.6) with antitumour therapy and 2.5 months (1.8-3.5) in untreated patients. OS1 was 12.8 months (10.7-15.2) and OS2 6.2 months (5.4-8.9) in treated dMMR patients. Treated dMMR patients had a 7.6-month shorter median OS than pMMR patients.Conclusion: Available data from immunotherapy trials lack a control arm with standard systemic treatment. Given the poor outcome compared to the immunotherapy results, our data strongly suggest a survival benefit of immunotherapy in dMMR mCRC patients. [ABSTRACT FROM AUTHOR]- Published
- 2021
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17. Chemotherapy versus chemoradiotherapy after surgery and preoperative chemotherapy for resectable gastric cancer (CRITICS): an international, open-label, randomised phase 3 trial
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Cats, Annemieke, primary, Jansen, Edwin P M, additional, van Grieken, Nicole C T, additional, Sikorska, Karolina, additional, Lind, Pehr, additional, Nordsmark, Marianne, additional, Meershoek-Klein Kranenbarg, Elma, additional, Boot, Henk, additional, Trip, Anouk K, additional, Swellengrebel, H A Maurits, additional, van Laarhoven, Hanneke W M, additional, Putter, Hein, additional, van Sandick, Johanna W, additional, van Berge Henegouwen, Mark I, additional, Hartgrink, Henk H, additional, van Tinteren, Harm, additional, van de Velde, Cornelis J H, additional, Verheij, Marcel, additional, Van Coevorden, Frits, additional, Vanhoutvin, Steven, additional, Hulshof, Maarten CCM, additional, Loosveld, Olaf JL, additional, Ten Tije, A (Bert) Jan, additional, Erdkamp, Frans LG, additional, Warmerdam, Fabienne ARM, additional, Van der Peet, Donald L, additional, Verheul, Henk MW, additional, Boerma, Djamila, additional, Los, Maartje, additional, Slot, Annerie, additional, Houtsma, Danny, additional, Portielje, Johanna EA, additional, Blaisse, Reinoud JB, additional, Spillenaar Bilgen, Ernst Jan, additional, Polée, Marco B, additional, Geenen, Maud M, additional, Braak, Jeffrey PBM, additional, Neelis, Karen J, additional, Slingerland, Marije, additional, Jansen, Rob LH, additional, Buijsen, Jeroen, additional, Beeker, Aart, additional, Eijsbouts, Quirijn AJ, additional, Van Riel, Johanna MGH, additional, Rozema, Tom, additional, Van Spronsen, Dick Johan, additional, Meerum Terwogt, Jetske M, additional, Tanis, Bea C, additional, Van der Torren-Conze, Adelheid ME, additional, Van Hilligersberg, Richard, additional, Koopman, Miriam, additional, Den Boer, Marien O, additional, Creemers, Geert-Jan, additional, Van der Sangen, Maurice, additional, Rentinck, Marjolein EM, additional, Van den Berg, H Pieter, additional, Jonkers, Ge JPM, additional, Grootenboers, Diane, additional, Vulink, Annelie JE, additional, Hovenga, Sjoerd, additional, Van der Mijle, Huub CJ, additional, Baars, Arnold, additional, Haringhuizen, Annebeth W, additional, Appels, Marije IE, additional, Rietbroek, Ron C, additional, Hendriksen, Ellen M, additional, Legdeur, Marie-Cecile JC, additional, Ten Bokkel Huinink, Daan, additional, Van Dobbenburgh, O Aart, additional, Smit, Jitty M, additional, Van Bochove, Aart, additional, Veldhuis, Gerrit-Jan, additional, Muller, Erik W, additional, Bonenkamp, J (Han) J, additional, Braam, Pètra M, additional, De Boer, Jaap, additional, Van Halteren, Henk K, additional, Valster, Fransje AA, additional, Imholz, Alex LT, additional, Van Dijk, Marjan A, additional, Van der Gaast, Ate, additional, Otten, J (Hans)-Martin MB, additional, Ceha, Heleen M, additional, Glimelius, Bengt, additional, Lagerbäck, Cecillia, additional, Perman, Mats, additional, Johnsson, Anders, additional, Borg, David, additional, Nielsen, Niels H, additional, Piwowar, Andrzej, additional, Elmlund, Mattias, additional, Hörberg, Helene, additional, Edlund, Per, additional, Johansson, Bengt, additional, Flygare, Petra, additional, and Jespersen, Marie Louise, additional
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- 2018
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18. Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to 5 Years after Diagnosis.
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Smit KC, Derksen JWG, Stellato RK, VAN Lanen AS, Wesselink E, Belt EJT, Balen MC, Coene PPLO, Dekker JWT, DE Groot JW, Haringhuizen AW, VAN Halteren HK, VAN Heek TT, Helgason HH, Hendriks MP, DE Hingh IHJT, Hoekstra R, Houtsma D, Janssen JJB, Kok N, Konsten JLM, Los M, Meijerink MR, Mekenkamp LJM, Peeters KCMJ, Polée MB, Rietbroek RC, Schiphorst AHW, Schrauwen RWM, Schreinemakers J, Sie MPS, Simkens L, Sonneveld EJA, Terheggen F, Iersel LV, Vles WJ, Wasowicz-Kemps DK, DE Wilt JHW, Kok DE, Winkels RM, Kampman E, VAN Duijnhoven FJB, Koopman M, and May AM
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- Male, Humans, Female, Exercise, Cohort Studies, Fatigue, Quality of Life, Colorectal Neoplasms diagnosis
- Abstract
Introduction: Physical activity (PA) is associated with higher quality of life and probably better prognosis among colorectal cancer (CRC) patients. This study focuses on determinants of PA among CRC patients from diagnosis until 5 yr postdiagnosis., Methods: Sociodemographic and disease-related factors of participants of two large CRC cohort studies were combined. Moderate-to-vigorous PA during sport and leisure time (MVPA-SL) was measured at diagnosis (T0) and 6, 12, 24, and 60 months (T6 to T60) postdiagnosis, using the SQUASH questionnaire. Mixed-effects models were performed to identify sociodemographic and disease-related determinants of MVPA-SL, separately for stage I-III colon (CC), stage I-III rectal cancer (RC), and stage IV CRC (T0 and T6 only). Associations were defined as consistently present when significant at ≥4 timepoints for the stage I-III subsets. MVPA-SL levels were compared with an age- and sex-matched sample of the general Dutch population., Results: In total, 2905 CC, 1459 RC and 436 stage IV CRC patients were included. Patients with higher fatigue scores, and women compared with men had consistently lower MVPA-SL levels over time, regardless of tumor type and stage. At T6, having a stoma was significantly associated with lower MVPA-SL among stage I-III RC patients. Systemic therapy and radiotherapy were not significantly associated with MVPA-SL changes at T6. Compared with the general population, MVPA-SL levels of CRC patients were lower at all timepoints, most notably at T6., Conclusions: Female sex and higher fatigue scores were consistent determinants of lower MVPA-SL levels among all CRC patients, and MVPA-SL levels were lowest at 6 months postdiagnosis. Our results can inform the design of intervention studies aimed at improving PA, and guide healthcare professionals in optimizing individualized support., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine.)
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- 2024
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19. Physical Activity Is Associated with Improved Overall Survival among Patients with Metastatic Colorectal Cancer.
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Smit KC, Derksen JWG, Beets GLO, Belt EJT, Berbée M, Coene PPLO, van Cruijsen H, Davidis MA, Dekker JWT, van Dodewaard-de Jong JM, Haringhuizen AW, Helgason HH, Hendriks MP, Hoekstra R, de Hingh IHJT, IJzermans JNM, Janssen JJB, Konsten JLM, Los M, Mekenkamp LJM, Nieboer P, Peeters KCMJ, Peters NAJB, Pruijt HJFM, Quarles van Ufford-Mannesse P, Rietbroek RC, Schiphorst AHW, Schouten van der Velden A, Schrauwen RWM, Sie MPS, Sommeijer DW, Sonneveld DJA, Stockmann HBAC, Tent M, Terheggen F, Tjin-A-Ton MLR, Valkenburg-van Iersel L, van der Velden AMT, Vles WJ, van Voorthuizen T, Wegdam JA, de Wilt JHW, Koopman M, May AM, and On Behalf Of The Plcrc Study Group
- Abstract
Regular physical activity (PA) is associated with improved overall survival (OS) in stage I-III colorectal cancer (CRC) patients. This association is less defined in patients with metastatic CRC (mCRC). We therefore conducted a study in mCRC patients participating in the Prospective Dutch Colorectal Cancer cohort. PA was assessed with the validated SQUASH questionnaire, filled-in within a maximum of 60 days after diagnosis of mCRC. PA was quantified by calculating Metabolic Equivalent Task (MET) hours per week. American College of Sports and Medicine (ACSM) PA guideline adherence, tertiles of moderate to vigorous PA (MVPA), and sport and leisure time MVPA (MVPA-SL) were assessed as well. Vital status was obtained from the municipal population registry. Cox proportional-hazards models were used to study the association between PA determinants and all-cause mortality adjusted for prognostic patient and treatment-related factors. In total, 293 mCRC patients (mean age 62.9 ± 10.6 years, 67% male) were included in the analysis. Compared to low levels, moderate and high levels of MET-hours were significantly associated with longer OS (fully adjusted hazard ratios: 0.491, (95% CI 0.299-0.807, p value = 0.005) and 0.485 (95% CI 0.303-0.778, p value = 0.003), respectively), as were high levels of MVPA (0.476 (95% CI 0.278-0.816, p value = 0.007)) and MVPA-SL (0.389 (95% CI 0.224-0.677, p value < 0.001)), and adherence to ACSM PA guidelines compared to non-adherence (0.629 (95% CI 0.412-0.961, p value = 0.032)). The present study provides evidence that higher PA levels at diagnosis of mCRC are associated with longer OS.
- Published
- 2022
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