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2. Radiotherapy-induced vascular cognitive impairment 20 years after childhood brain tumor.

Author

Remes, Tiina Maria, Suo-Palosaari, Maria Helena, Arikoski, Pekka Matti, Harila, Marika, Koskenkorva, Päivi Katri Tuulikki, Lähteenmäki, Päivi Maria, Lönnqvist, Tuula Riitta Irmeli, Ojaniemi, Marja Katariina, Pohjasniemi, Heli, Puosi, Riina, Ritari, Niina, Sirkiä, Kirsti Helena, Sutela, Anna Kaarina, Toiviainen-Salo, Sanna-Maria, Rantala, Heikki Markku Johannes, and Harila, Arja Helena

Published
2024
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3. Radiotherapy-induced vascular cognitive impairment 20 years after childhood brain tumor

Author

Remes, Tiina Maria, primary, Suo-Palosaari, Maria Helena, additional, Arikoski, Pekka Matti, additional, Harila, Marika, additional, Koskenkorva, Päivi Katri Tuulikki, additional, Lähteenmäki, Päivi Maria, additional, Lönnqvist, Tuula Riitta Irmeli, additional, Ojaniemi, Marja Katariina, additional, Pohjasniemi, Heli, additional, Puosi, Riina, additional, Ritari, Niina, additional, Sirkiä, Kirsti Helena, additional, Sutela, Anna Kaarina, additional, Toiviainen-Salo, Sanna-Maria, additional, Rantala, Heikki Markku Johannes, additional, and Harila, Arja Helena, additional

Published
2023
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5. Neurocognitive impairment, employment, and social status in radiotherapy-treated adult survivors of childhood brain tumors

Author

Remes, Tiina M., Hovén, Emma, Ritari, Niina, Pohjasniemi, Heli, Puosi, Riina, Arikoski, Pekka M., Arola, Mikko O., Lähteenmäki, Päivi M., Lönnqvist, Tuula R. I., Ojaniemi, Marja K., Riikonen, V. Pekka, Sirkiä, Kirsti H., Winqvist, Satu, Rantala, Heikki M. J., Harila, Marika, Harila-Saari, Arja H., Remes, Tiina M., Hovén, Emma, Ritari, Niina, Pohjasniemi, Heli, Puosi, Riina, Arikoski, Pekka M., Arola, Mikko O., Lähteenmäki, Päivi M., Lönnqvist, Tuula R. I., Ojaniemi, Marja K., Riikonen, V. Pekka, Sirkiä, Kirsti H., Winqvist, Satu, Rantala, Heikki M. J., Harila, Marika, and Harila-Saari, Arja H.

Abstract

Background Little is known of the cognitive functions, employment, and social status in adult survivors of childhood brain tumor (BT). We aimed to determine the long-term neurocognitive profile of radiotherapy-treated adult survivors of childhood BT and the relationship between cognitive functions and employment and social status. Methods Neurocognitive profiles of survivors were assessed in a Finnish national cohort of 71 radiotherapy-treated survivors of childhood BT (median follow-up time: 21 years [range: 5-33 years]) using a cross-sectional design. Neurocognitive outcomes were compared to control (n = 45) and normative values. Tumor- and treatment-related data were collected from the patient files. Information on employment and social status was gathered. Results Survivors’ (median age: 27 years [range: 16-43 years]) median verbal and performance intelligence quotient (IQ) was 90 (range: 49-121) and 87 (range: 43-119), respectively. The cognitive domains with the greatest impairment were executive functions (median z score, −3.5 SD [range: −25.0 to 1.3 SD]), and processing speed and attention (median z score, −2.5 SD [range: −24.9 to 0.5 SD]). Executive functions were associated with employment, educational level, living independently, having an intimate relationship, and having a driving license. Processing speed and attention were related to educational level, living independently, having an intimate relationship, and having a driving license. Performance IQ was associated with educational level and employment status. Working memory was associated with educational level and living independently. Conclusions Radiotherapy-treated adult survivors of childhood BT experience significant neurocognitive impairment, which is associated with difficulties related to employment and social status.

Published
2021
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6. Neurocognitive impairment, employment, and social status in radiotherapy-treated adult survivors of childhood brain tumors

Author

Remes, Tiina M, primary, Hovén, Emma, additional, Ritari, Niina, additional, Pohjasniemi, Heli, additional, Puosi, Riina, additional, Arikoski, Pekka M, additional, Arola, Mikko O, additional, Lähteenmäki, Päivi M, additional, Lönnqvist, Tuula R I, additional, Ojaniemi, Marja K, additional, Riikonen, V Pekka, additional, Sirkiä, Kirsti H, additional, Winqvist, Satu, additional, Rantala, Heikki M J, additional, Harila, Marika, additional, and Harila-Saari, Arja H, additional

Published
2021
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7. QOL-12. CLINICAL SIGNIFICANCE OF RADIATION-INDUCED CEREBROVASULAR DISEASE IN CHILDHOOD BRAIN TUMOR SURVIVORS

Author

Remes, Tiina, primary, Suo-Palosaari, Maria, additional, Ritari, Niina, additional, Puosi, Riina, additional, Koskenkorva, Päivi, additional, Sutela, Anna, additional, Toiviainen-Salo, Sanna-Maria, additional, Arikoski, Pekka, additional, Arola, Mikko, additional, Hovén, Emma, additional, Lähteenmäki, Päivi, additional, Lönnqvist, Tuula, additional, Riikonen, Pekka, additional, Sirkiä, Kirsti, additional, Rantala, Heikki, additional, Harila, Marika, additional, Ojaniemi, Marja, additional, and Harila-Saari, Arja, additional

Published
2020
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10. Reading, listening and memory-related brain activity in children with early-stage temporal lobe epilepsy of unknown cause-an fMRI study

Author

Mankinen, Katariina, primary, Ipatti, Pieta, additional, Harila, Marika, additional, Nikkinen, Juha, additional, Paakki, Jyri-Johan, additional, Rytky, Seppo, additional, Starck, Tuomo, additional, Remes, Jukka, additional, Tokariev, Maksym, additional, Carlson, Synnöve, additional, Tervonen, Osmo, additional, Rantala, Heikki, additional, and Kiviniemi, Vesa, additional

Published
2015
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