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414 results on '"Harel, Ziv"'

1. Alcalose metabolique et hypokaliemie chez une femme de 23 ans

Author

Kamel, Kamel S., Shapiro, Joshua, and Harel, Ziv

Subjects
Genetic disorders -- Diagnosis -- Complications and side effects, Alkalosis -- Causes of -- Care and treatment, Kidney diseases -- Complications and side effects -- Diagnosis, Health, Diagnosis, Care and treatment, Complications and side effects, Causes of
Abstract

Une femme de 23 ans sans antecedents medicaux notables a consulte a notre clinique de nephrologie pour des anomalies electrolytiques decelees aux analyses de laboratoire demandees par son medecin de [...]

Published
2024
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2. Anticoagulation for Patients with Atrial Fibrillation Receiving Dialysis: A Pilot Randomized Controlled Trial

Author

Harel, Ziv, Smyth, Brendan, Badve, Sunil V., Blum, Daniel, Beaubien-Souligny, William, Silver, Samuel A., Clark, Edward, Suri, Rita, Mavrakanas, Thomas A., Sasal, Joanna, Prasad, Bhanu, Eikelboom, John, Tennankore, Karthik, Rigatto, Claudio, Prce, Ivana, Madore, Francois, Mac-Way, Fabrice, Steele, Andrew, Zeng, Yangmin, Sholzberg, Michelle, Dorian, Paul, Yan, Andrew T., Sood, Manish M., Gladstone, David J., Tseng, Eric, Kitchlu, Abhijat, Walsh, Michael, Sapir, Danny, Oliver, Matthew J., Krishnan, Murali, Kiaii, Mercedeh, Wong, Nikki, Kotwal, Sradha, Batisstella, Marissa, Acedillo, Rey, Lok, Charmaine, Weir, Matthew, and Wald, Ron

Published
2024
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3. A 23-year-old woman with metabolic alkalosis and hypokalemia

Author

Kamel, Kamel S., Shapiro, Joshua, and Harel, Ziv

Subjects
Alkalosis -- Diagnosis -- Care and treatment, Hypokalemia -- Diagnosis -- Care and treatment, Muscle weakness -- Causes of -- Care and treatment, Body mass index -- Health aspects, Health
Abstract

A 23-year-old woman with no notable medical history was seen in our nephrology clinic for electrolyte abnormalities detected on laboratory testing ordered by her primary care physician, who she had [...]

Published
2024
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5. Safety and Effectiveness of Rivaroxaban Versus Warfarin Across GFR Levels in Atrial Fibrillation: A Population-Based Study in Australia and Canada

Author

Ha, Jeffrey T., Scaria, Anish, Andrade, Jason, Badve, Sunil V., Birks, Peter, Bota, Sarah E., Campain, Anna, Djurdjev, Ognjenka, Garg, Amit X., Harel, Ziv, Hemmelgarn, Brenda, Hockham, Carinna, James, Matthew T., Jardine, Meg J., Lam, Dickson, Levin, Adeera, McArthur, Eric, Ravani, Pietro, Shao, Selena, Sood, Manish M., Tan, Zhi, Tangri, Navdeep, Whitlock, Reid, Gallagher, Martin, and Jun, Min

Published
2023
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17. Prepregnancy renal function and risk of preterm birth and related outcomes

Author

Harel, Ziv, Park, Alison L., McArthur, Eric, Hladunewich, Michelle, Dirk, Jade S., Wald, Ron, Garg, Amit X., and Ray, Joel G.

Subjects
Premature infants, Blood tests, Pregnancy, Kidney diseases -- Risk factors, Pregnant women, Health
Abstract

BACKGROUND: Prepregnancy kidney dysfunction has been associated with preterm birth, which is the leading cause of neonatal morbidity and mortality; however, the relation is not well understood. We determined the risk of preterm birth in women with prepregnancy kidney dysfunction, defined using pregnancy-specific serum creatinine cut points. METHODS: This population-based cohort study in the province of Ontario, Canada, involved women aged 16 to 50 years who had a singleton birth between 2006 and 2016 and measurement of serum creatinine within 10 weeks preceding their estimated conception date. The exposure was abnormally elevated prepregnancy serum creatinine, defined as greater than the 95th percentile (> 77 [micro]mol/L), a value derived from a population-based sample of women without known kidney disease who became pregnant soon after the measurement was obtained. The main outcome was any preterm birth from 23 to 36 weeks' gestation. Secondary outcomes included provider-initiated preterm birth before 37 weeks' gestation and spontaneous preterm birth before 37 weeks. RESULTS: Among 55 946 pregnancies, preterm birth before 37 weeks' gestation occurred in 3956 women (7.1%). The risk of preterm birth before 37 weeks was higher among women with prepregnancy creatinine above the 95th percentile, relative to those with prepregnancy creatinine at or below the 95th percentile (9.1% v. 7.0%; adjusted relative risk [RR] 1.23, 95% confidence interval [CI] 1.09 to 1.38). The effect was significant for provider-initiated preterm birth (adjusted RR 1.30, 95% CI 1.11 to 1.52) but not for spontaneous preterm birth (adjusted RR 1.12, 95% CI 0.91 to 1.37). INTERPRETATION: Given that prepregnancy kidney dysfunction conferred an increased risk of preterm birth, measurement of serum creatinine (a relatively inexpensive blood test) may form part of the assessment of risk for preterm birth among those planning pregnancy., Prepregnancy kidney dysfunction may perturb the normal physiologic adaptations of pregnancy, predisposing a woman and her fetus to adversity, at least partly mediated by placental and endothelial dysfunction. (1) Complications [...]

Published
2020
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28. Risk of severe maternal morbidity or death in relation to elevated hemoglobin A1c preconception, and in early pregnancy: A population-based cohort study

Author

Davidson, Alexander J. F., Park, Alison L., Berger, Howard, Aoyama, Kazuyoshi, Harel, Ziv, Cook, Jocelynn L., and Ray, Joel G.

Subjects
Maternal mortality, Diabetes mellitus, Glucose, Morbidity, Glycosylated hemoglobin, Pregnant women, Biological sciences
Abstract

Background The relation between prepregnancy average glucose concentration and a woman's risk of severe maternal morbidity (SMM) is unknown. The current study evaluated whether an elevated preconception hemoglobin A1c (A1c) is associated with SMM or maternal death among women with and without known prepregnancy diabetes mellitus (DM). Methods and findings A population-based cohort study was completed in Ontario, Canada, where there is universal healthcare. The main cohort included 31,225 women aged 16-50 years with a hospital live birth or stillbirth from 2007 to 2015, and who had an A1c measured within 90 days before conception, including 28,075 women (90%) without known prepregnancy DM. The main outcome was SMM or maternal mortality from 23 weeks' gestation up to 42 days postpartum. Relative risks (RRs) were generated using modified Poisson regression, adjusting for the main covariates of maternal age, multifetal pregnancy, world region of origin, and tobacco/drug dependence. The mean maternal age was 31.1 years. Overall, SMM or death arose among 682 births (2.2%). The RR of SMM or death was 1.16 (95% CI 1.14-1.19; p < 0.001) per 0.5% increase in A1c and 1.16 (95% CI 1.13-1.18; p < 0.001) after adjusting for the main covariates. The adjusted relative risk (aRR) was increased among those with (1.11, 95% CI 1.07-1.14; p < 0.001) and without (1.15, 95% CI 1.02-1.29; p < 0.001) known prepregnancy diabetes, and upon further adjusting for body mass index (BMI) (1.15, 95% CI 1.11-1.20; p < 0.001), or chronic hypertension and prepregnancy serum creatinine (1.11, 95% CI 1.04-1.18; p = 0.002). The aRR of SMM or death was 1.31 (95% CI 1.06-1.62; p = 0.01) in those with a preconception A1c of 5.8%-6.4%, and 2.84 (95% CI 2.31-3.49; p 6.4%, each relative to an A1c 6.4%, the aRR of SMM or death was 3.25 (95% CI 1.76-6.00; p < 0.001). Study limitations include that selection bias may have incorporated less healthy women tested for A1c, and BMI was unknown for many women. Conclusions Our findings indicate that women with an elevated A1c preconception may be at higher risk of SMM or death in pregnancy or postpartum, including those without known prepregnancy DM., Author(s): Alexander J. F. Davidson 1, Alison L. Park 1,2, Howard Berger 1,3,4, Kazuyoshi Aoyama 1,5, Ziv Harel 1,2,3, Jocelynn L. Cook 6,7, Joel G. Ray 1,2,3,4,* Introduction The prevalence [...]

Published
2020
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30. Association of an Acute Kidney Injury Follow-up Clinic With Patient Outcomes and Care Processes: A Cohort Study

Author

Silver, Samuel A., primary, Adhikari, Neill K., additional, Jeyakumar, Nivethika, additional, Luo, Bin, additional, Harel, Ziv, additional, Dixon, Stephanie N., additional, Brimble, K. Scott, additional, Clark, Edward G., additional, Neyra, Javier A., additional, Vijayaraghavan, Bharath K.T., additional, Garg, Amit X., additional, Bell, Chaim M., additional, and Wald, Ron, additional

Published
2022
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31. Cardiovascular Drug Use After Acute Kidney Injury Among Hospitalized Patients With a History of Myocardial Infarction

Author

Meraz-Muñoz, Alejandro Y., primary, Jeyakumar, Nivethika, additional, Luo, Bin, additional, Beaubien-Souligny, William, additional, Chanchlani, Rahul, additional, Clark, Edward G., additional, Harel, Ziv, additional, Kitchlu, Abhijat, additional, Neyra, Javier A., additional, Zappitelli, Michael, additional, Chertow, Glenn M., additional, Garg, Amit X., additional, Wald, Ron, additional, and Silver, Samuel A., additional

Published
2022
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34. Kidney function and the comparative effectiveness and safety of direct oral anticoagulants vs. warfarin in adults with atrial fibrillation: a multicenter observational study

Author

Jun, Min, primary, Scaria, Anish, additional, Andrade, Jason, additional, Badve, Sunil V, additional, Birks, Peter, additional, Bota, Sarah E, additional, Campain, Anna, additional, Djurdjev, Ognjenka, additional, Garg, Amit X, additional, Ha, Jeffrey, additional, Harel, Ziv, additional, Hemmelgarn, Brenda, additional, Hockham, Carinna, additional, James, Matthew T, additional, Jardine, Meg J, additional, Levin, Adeera, additional, McArthur, Eric, additional, Ravani, Pietro, additional, Shao, Selena, additional, Sood, Manish M, additional, Tan, Zhi, additional, Tangri, Navdeep, additional, Whitlock, Reid, additional, and Gallagher, Martin, additional

Published
2022
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42. Hypernatremia

Author

Kamel, Kamel S., primary, Schreiber, Martin, additional, and Harel, Ziv, additional

Published
2022
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43. sj-pdf-1-cjk-10.1177_20543581221103682 – Supplemental material for Use of Guideline-Based Therapy for Diabetes, Coronary Artery Disease, and Chronic Kidney Disease After Acute Kidney Injury: A Retrospective Observational Study

Author

Madan, Sunchit, Norman, Patrick A., Wald, Ron, Neyra, Javier A., Meraz-Muñoz, Alejandro, Harel, Ziv, and Silver, Samuel A.

Subjects
Medicine, humanities
Abstract

Supplemental material, sj-pdf-1-cjk-10.1177_20543581221103682 for Use of Guideline-Based Therapy for Diabetes, Coronary Artery Disease, and Chronic Kidney Disease After Acute Kidney Injury: A Retrospective Observational Study by Sunchit Madan, Patrick A. Norman, Ron Wald, Javier A. Neyra, Alejandro Meraz-Muñoz, Ziv Harel and Samuel A. Silver in Canadian Journal of Kidney Health and Disease

Published
2022
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50. The Risk of Acute Kidney Injury with Oral Anticoagulants in Elderly Adults with Atrial Fibrillation

Author

Harel, Ziv, primary, McArthur, Eric, additional, Jeyakumar, Nivethika, additional, Sood, Manish M., additional, Garg, Amit X., additional, Silver, Samuel A., additional, Dorian, Paul, additional, Blum, Daniel, additional, Beaubien-Souligny, William, additional, Yan, Andrew T., additional, Badve, Sunil V., additional, Smyth, Brendan, additional, Jun, Min, additional, Jandoc, Racquel, additional, Kitchlu, Abhijat, additional, and Wald, Ron, additional

Published
2021
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